locus-tag	class	description
BcFMB_RS00130	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BcFMB_RS00140	COG0768	penicillin binding
BcFMB_RS00165	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BcFMB_RS00200	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BcFMB_RS00205	COG2813	Specifically methylates the guanine in position
BcFMB_RS00210	COG1643	Atp-dependent helicase
BcFMB_RS00260	COG0587	DNA-directed DNA polymerase activity
BcFMB_RS00290	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BcFMB_RS00330	COG1609	Transcriptional regulator
BcFMB_RS00335	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BcFMB_RS00345	COG1957	nucleoside hydrolase
BcFMB_RS00395	COG3480	Lon protease (S16) C-terminal proteolytic domain
BcFMB_RS00430	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BcFMB_RS00450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BcFMB_RS00455	COG1126	abc transporter atp-binding protein
BcFMB_RS00460	COG0765	amino acid transport
BcFMB_RS00465	COG0765	amino acid transport
BcFMB_RS00470	COG0436	Aminotransferase
BcFMB_RS00475	COG2011	ABC-type metal ion transport system permease component
BcFMB_RS00480	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BcFMB_RS00485	COG1464	Belongs to the NlpA lipoprotein family
BcFMB_RS00490	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BcFMB_RS00495	COG0531	amino acid
BcFMB_RS00555	COG2814	Major facilitator Superfamily
BcFMB_RS00580	COG1842	Phage shock protein A
BcFMB_RS00610	COG2365	Tyrosine phosphatase family
BcFMB_RS00615	COG1132	(ABC) transporter
BcFMB_RS00620	COG1132	(ABC) transporter
BcFMB_RS00635	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BcFMB_RS00640	COG1518	maintenance of DNA repeat elements
BcFMB_RS00685	COG1924	4 iron, 4 sulfur cluster binding
BcFMB_RS00700	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BcFMB_RS00700	COG1328	CTP reductase activity
BcFMB_RS00705	COG1570	exodeoxyribonuclease VII activity
BcFMB_RS00710	COG1722	exodeoxyribonuclease VII activity
BcFMB_RS00730	COG0248	Ppx GppA phosphatase
BcFMB_RS00735	COG0436	Aminotransferase
BcFMB_RS00760	COG0531	amino acid
BcFMB_RS00765	COG3579	cysteine-type endopeptidase activity
BcFMB_RS00790	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BcFMB_RS00825	COG0515	serine threonine protein kinase
BcFMB_RS00825	COG2815	serine threonine protein kinase
BcFMB_RS00835	COG0714	Associated with various cellular activities
BcFMB_RS00880	COG1194	a g-specific adenine glycosylase
BcFMB_RS00885	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BcFMB_RS00905	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
BcFMB_RS00915	COG1349	DNA-binding transcription factor activity
BcFMB_RS00920	COG0463	Glycosyl transferase, family 2
BcFMB_RS00925	COG0167	dihydroorotate dehydrogenase activity
BcFMB_RS00930	COG1902	pentaerythritol trinitrate reductase activity
BcFMB_RS00935	COG4499	WXG100 protein secretion system (Wss), protein YukC
BcFMB_RS00935	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BcFMB_RS00950	COG2314	TM2 domain
BcFMB_RS00990	COG2267	carboxylic ester hydrolase activity
BcFMB_RS01000	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BcFMB_RS01020	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
BcFMB_RS01030	COG1088	dTDP-glucose 4,6-dehydratase activity
BcFMB_RS01035	COG1215	transferase activity, transferring glycosyl groups
BcFMB_RS01050	COG1216	Glycosyl transferase, family 2
BcFMB_RS01080	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BcFMB_RS01090	COG2814	Major facilitator Superfamily
BcFMB_RS01105	COG1609	Transcriptional regulator
BcFMB_RS01130	COG1132	(ABC) transporter
BcFMB_RS01145	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BcFMB_RS01160	COG5039	Polysaccharide pyruvyl transferase
BcFMB_RS01175	COG1216	Glycosyl transferase, family 2
BcFMB_RS01175	COG1442	glycosyl transferase family 8
BcFMB_RS01195	COG0438	transferase activity, transferring glycosyl groups
BcFMB_RS01210	COG1216	Glycosyl transferase, family 2
BcFMB_RS01215	COG0366	Alpha amylase catalytic
BcFMB_RS01220	COG0366	Alpha amylase catalytic
BcFMB_RS01225	COG0366	Alpha amylase catalytic
BcFMB_RS01235	COG0489	protein tyrosine kinase activity
BcFMB_RS01240	COG0083	homoserine kinase activity
BcFMB_RS01245	COG0460	homoserine dehydrogenase
BcFMB_RS01270	COG0251	oxidation-reduction process
BcFMB_RS01300	COG0545	Peptidyl-prolyl cis-trans isomerase
BcFMB_RS01310	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BcFMB_RS01345	COG0356	it plays a direct role in the translocation of protons across the membrane
BcFMB_RS01465	COG4974	Belongs to the 'phage' integrase family
BcFMB_RS01475	COG0679	Auxin Efflux Carrier
BcFMB_RS01480	COG0028	Belongs to the TPP enzyme family
BcFMB_RS01485	COG0038	chloride channel
BcFMB_RS01500	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BcFMB_RS01510	COG0745	RESPONSE REGULATOR receiver
BcFMB_RS01520	COG0747	negative chemotaxis
BcFMB_RS01535	COG1605	Chorismate mutase
BcFMB_RS01535	COG0287	Prephenate dehydrogenase
BcFMB_RS01580	COG1131	(ABC) transporter
BcFMB_RS01595	COG2217	Heavy metal translocating P-type atpase
BcFMB_RS01595	COG2217	Heavy metal translocating P-type atpase
BcFMB_RS01605	COG0179	Fumarylacetoacetate (FAA) hydrolase
BcFMB_RS01610	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BcFMB_RS01625	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BcFMB_RS01680	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BcFMB_RS01695	COG1609	Transcriptional regulator
BcFMB_RS01735	COG1368	sulfuric ester hydrolase activity
BcFMB_RS01740	COG1216	Glycosyl transferase, family 2
BcFMB_RS01745	COG3757	hydrolase, family 25
BcFMB_RS01745	COG3409	Peptidoglycan-binding domain 1 protein
BcFMB_RS01765	COG1216	Glycosyl transferase, family 2
BcFMB_RS01800	COG1397	ADP-ribosylglycohydrolase
BcFMB_RS01840	COG0084	hydrolase, TatD family'
BcFMB_RS01850	COG1132	(ABC) transporter
BcFMB_RS01855	COG1132	(ABC) transporter
BcFMB_RS01895	COG1940	carbohydrate kinase activity
BcFMB_RS01905	COG1501	Belongs to the glycosyl hydrolase 31 family
BcFMB_RS01910	COG1472	Belongs to the glycosyl hydrolase 3 family
BcFMB_RS01925	COG0395	ABC-type sugar transport system, permease component
BcFMB_RS01930	COG4209	transmembrane transport
BcFMB_RS01940	COG0586	Pfam SNARE associated Golgi protein
BcFMB_RS01945	COG1501	Belongs to the glycosyl hydrolase 31 family
BcFMB_RS01955	COG1175	transmembrane transport
BcFMB_RS01965	COG1609	Transcriptional regulator
BcFMB_RS02000	COG0395	ABC-type sugar transport system, permease component
BcFMB_RS02005	COG1175	transmembrane transport
BcFMB_RS02020	COG1940	carbohydrate kinase activity
BcFMB_RS02025	COG1940	carbohydrate kinase activity
BcFMB_RS02045	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BcFMB_RS02050	COG0789	Transcriptional regulator
BcFMB_RS02055	COG0484	heat shock protein binding
BcFMB_RS02080	COG0546	phosphoglycolate phosphatase activity
BcFMB_RS02085	COG1523	belongs to the glycosyl hydrolase 13 family
BcFMB_RS02090	COG3833	ABC-type maltose transport systems, permease component
BcFMB_RS02095	COG1175	transmembrane transport
BcFMB_RS02105	COG0366	Alpha amylase catalytic
BcFMB_RS02130	COG1609	Transcriptional regulator
BcFMB_RS02140	COG0366	Alpha amylase catalytic
BcFMB_RS02145	COG0588	phosphoglycerate mutase activity
BcFMB_RS02155	COG0778	Nitroreductase
BcFMB_RS02190	COG0477	Major facilitator Superfamily
BcFMB_RS02215	COG2814	Major facilitator Superfamily
BcFMB_RS02220	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BcFMB_RS02235	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BcFMB_RS02240	COG0366	Alpha amylase catalytic
BcFMB_RS02250	COG0395	ABC-type sugar transport system, permease component
BcFMB_RS02255	COG1175	transmembrane transport
BcFMB_RS02275	COG0590	tRNA wobble adenosine to inosine editing
BcFMB_RS02275	COG0037	tRNA processing
BcFMB_RS02280	COG0025	NhaP-type Na H and K H
BcFMB_RS02300	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BcFMB_RS02305	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BcFMB_RS02315	COG3842	ATPase activity
BcFMB_RS02345	COG3583	domain protein
BcFMB_RS02365	COG0617	tRNA 3'-terminal CCA addition
BcFMB_RS02385	COG0492	ferredoxin-NADP+ reductase activity
BcFMB_RS02395	COG1192	Involved in chromosome partitioning
BcFMB_RS02415	COG0531	amino acid
BcFMB_RS02420	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
BcFMB_RS02435	COG1454	alcohol dehydrogenase
BcFMB_RS02440	COG1847	R3H domain protein
BcFMB_RS02485	COG0187	DNA topoisomerase II activity
BcFMB_RS02490	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BcFMB_RS02505	COG1272	protein, Hemolysin III
BcFMB_RS02510	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BcFMB_RS02525	COG1970	mechanosensitive ion channel activity
BcFMB_RS02575	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
BcFMB_RS02580	COG3231	kanamycin kinase activity
BcFMB_RS02595	COG2020	methyltransferase activity
BcFMB_RS02690	COG0783	Belongs to the Dps family
BcFMB_RS02695	COG1253	flavin adenine dinucleotide binding
BcFMB_RS02705	COG0288	reversible hydration of carbon dioxide
BcFMB_RS02710	COG1609	Transcriptional regulator
BcFMB_RS02730	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
BcFMB_RS02745	COG0180	Tryptophanyl-tRNA synthetase
BcFMB_RS02760	COG0058	SHG alpha-glucan phosphorylase activity
BcFMB_RS02805	COG0515	serine threonine protein kinase
BcFMB_RS02810	COG0768	penicillin binding
BcFMB_RS02825	COG1716	ATPase activity
BcFMB_RS02850	COG0697	spore germination
BcFMB_RS02865	COG2226	methyltransferase
BcFMB_RS02895	COG2910	NAD(P)H-binding
BcFMB_RS02900	COG0343	queuine tRNA-ribosyltransferase activity
BcFMB_RS02910	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BcFMB_RS02915	COG2217	Heavy metal translocating P-type atpase
BcFMB_RS02955	COG2814	Major facilitator Superfamily
BcFMB_RS03040	COG1063	alcohol dehydrogenase
BcFMB_RS03045	COG0583	DNA-binding transcription factor activity
BcFMB_RS03055	COG0191	fructose-bisphosphate aldolase activity
BcFMB_RS03075	COG1172	Belongs to the binding-protein-dependent transport system permease family
BcFMB_RS03110	COG2211	Major facilitator Superfamily
BcFMB_RS03130	COG0477	Major facilitator Superfamily
BcFMB_RS03155	COG2182	Extracellular solute-binding protein
BcFMB_RS03160	COG2182	Extracellular solute-binding protein
BcFMB_RS03165	COG1175	transmembrane transport
BcFMB_RS03170	COG0395	ABC-type sugar transport system, permease component
BcFMB_RS03180	COG1609	Transcriptional regulator
BcFMB_RS03205	COG1113	amino acid transport
BcFMB_RS03220	COG1136	(ABC) transporter
BcFMB_RS03220	COG4591	ABC-type transport system involved in lipoprotein release permease component
BcFMB_RS03230	COG1113	amino acid transport
BcFMB_RS03235	COG1846	Transcriptional regulator
BcFMB_RS03260	COG0671	phosphoesterase, PA-phosphatase related
BcFMB_RS03310	COG1309	transcriptional regulator
BcFMB_RS03330	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
BcFMB_RS03340	COG0305	Participates in initiation and elongation during chromosome replication
BcFMB_RS03345	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BcFMB_RS03365	COG0584	glycerophosphoryl diester phosphodiesterase
BcFMB_RS03395	COG0406	alpha-ribazole phosphatase activity
BcFMB_RS03395	COG0494	nUDIX hydrolase
BcFMB_RS03400	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BcFMB_RS03480	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BcFMB_RS03500	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BcFMB_RS03500	COG1754	DNA topoisomerase type I activity
BcFMB_RS03510	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BcFMB_RS03605	COG0446	pyridine nucleotide-disulphide oxidoreductase
BcFMB_RS03610	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BcFMB_RS03660	COG0436	Aminotransferase
BcFMB_RS03680	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
BcFMB_RS03680	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
BcFMB_RS03690	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BcFMB_RS03700	COG0742	ribosomal rna small subunit methyltransferase
BcFMB_RS03715	COG1837	Belongs to the UPF0109 family
BcFMB_RS03750	COG0488	(ABC) transporter
BcFMB_RS03800	COG0667	Aldo Keto reductase
BcFMB_RS03870	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BcFMB_RS03895	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BcFMB_RS03900	COG1530	ribonuclease E activity
BcFMB_RS03950	COG0436	Aminotransferase
BcFMB_RS03995	COG1268	BioY protein
BcFMB_RS04000	COG4770	biotin carboxylase activity
BcFMB_RS04005	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BcFMB_RS04035	COG0039	L-malate dehydrogenase activity
BcFMB_RS04050	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BcFMB_RS04075	COG1704	LemA family
BcFMB_RS04095	COG0826	peptidase U32
BcFMB_RS04115	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
BcFMB_RS04125	COG3579	cysteine-type endopeptidase activity
BcFMB_RS04130	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BcFMB_RS04135	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
BcFMB_RS04135	COG2755	lipolytic protein G-D-S-L family
BcFMB_RS04140	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BcFMB_RS04145	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BcFMB_RS04150	COG5002	protein histidine kinase activity
BcFMB_RS04155	COG0745	RESPONSE REGULATOR receiver
BcFMB_RS04170	COG0581	inorganic phosphate transmembrane transporter activity
BcFMB_RS04200	COG2252	PERMEase
BcFMB_RS04260	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BcFMB_RS04300	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BcFMB_RS04305	COG0531	amino acid
BcFMB_RS04320	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BcFMB_RS04330	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BcFMB_RS04335	COG1739	Uncharacterized protein family UPF0029
BcFMB_RS04425	COG1454	alcohol dehydrogenase
BcFMB_RS04425	COG1012	belongs to the aldehyde dehydrogenase family
BcFMB_RS04480	COG0255	Belongs to the universal ribosomal protein uL29 family
BcFMB_RS04530	COG1841	ribosomal large subunit assembly
BcFMB_RS04640	COG0196	riboflavin kinase activity
BcFMB_RS04660	COG0328	RNA-DNA hybrid ribonuclease activity
BcFMB_RS04675	COG1803	Methylglyoxal synthase
BcFMB_RS04675	COG1597	lipid kinase activity
BcFMB_RS04720	COG2197	response regulator
BcFMB_RS04740	COG1136	(ABC) transporter
BcFMB_RS04740	COG0577	efflux transmembrane transporter activity
BcFMB_RS04745	COG0390	transport system, permease component
BcFMB_RS04755	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BcFMB_RS04770	COG1575	Belongs to the MenA family. Type 1 subfamily
BcFMB_RS04795	COG1401	restriction endodeoxyribonuclease activity
BcFMB_RS04820	COG4716	Myosin-crossreactive antigen
BcFMB_RS04825	COG0704	Plays a role in the regulation of phosphate uptake
BcFMB_RS04845	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BcFMB_RS04850	COG1388	LysM domain
BcFMB_RS04850	COG3942	CHAP domain
BcFMB_RS04855	COG1388	LysM domain
BcFMB_RS04855	COG0791	NLP P60 protein
BcFMB_RS04860	COG0589	response to stress
BcFMB_RS04875	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BcFMB_RS04880	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BcFMB_RS04885	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BcFMB_RS04965	COG3459	Glycosyltransferase 36 associated
BcFMB_RS04995	COG2027	D-alanyl-D-alanine carboxypeptidase
BcFMB_RS05010	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BcFMB_RS05025	COG1946	Acyl-CoA thioesterase
BcFMB_RS05035	COG0242	peptide deformylase activity
BcFMB_RS05040	COG2873	o-acetylhomoserine
BcFMB_RS05055	COG1070	Carbohydrate kinase
BcFMB_RS05060	COG1940	carbohydrate kinase activity
BcFMB_RS05100	COG0009	L-threonylcarbamoyladenylate synthase
BcFMB_RS05105	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BcFMB_RS05125	COG0561	phosphatase activity
BcFMB_RS05130	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BcFMB_RS05150	COG3590	peptidase
BcFMB_RS05160	COG0024	Methionine aminopeptidase
BcFMB_RS05165	COG0372	Belongs to the citrate synthase family
BcFMB_RS05185	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BcFMB_RS05190	COG2884	Cell division ATP-binding protein ftsE
BcFMB_RS05195	COG2177	Part of the ABC transporter FtsEX involved in
BcFMB_RS05200	COG1388	LysM domain
BcFMB_RS05200	COG3942	CHAP domain
BcFMB_RS05215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BcFMB_RS05220	COG0765	amino acid transport
BcFMB_RS05230	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BcFMB_RS05235	COG0564	pseudouridine synthase activity
BcFMB_RS05255	COG0747	negative chemotaxis
BcFMB_RS05265	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BcFMB_RS05275	COG4608	Belongs to the ABC transporter superfamily
BcFMB_RS05295	COG0514	ATP-dependent DNA helicase (RecQ)
BcFMB_RS05330	COG3311	Transcriptional regulator
BcFMB_RS05345	COG0494	nUDIX hydrolase
BcFMB_RS05390	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BcFMB_RS05400	COG0358	DNA primase activity
BcFMB_RS05405	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
BcFMB_RS05425	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BcFMB_RS05430	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BcFMB_RS05435	COG0735	belongs to the Fur family
BcFMB_RS05440	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
BcFMB_RS05455	COG0151	Belongs to the GarS family
BcFMB_RS05470	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BcFMB_RS05540	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BcFMB_RS05555	COG0438	transferase activity, transferring glycosyl groups
BcFMB_RS05625	COG0284	orotidine-5'-phosphate decarboxylase activity
BcFMB_RS05650	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BcFMB_RS05665	COG0560	Phosphoserine phosphatase
BcFMB_RS05670	COG0586	Pfam SNARE associated Golgi protein
BcFMB_RS05750	COG0714	Associated with various cellular activities
BcFMB_RS05765	COG1278	Cold shock
BcFMB_RS05785	COG0745	RESPONSE REGULATOR receiver
BcFMB_RS05790	COG2205	protein histidine kinase activity
BcFMB_RS05795	COG1278	Cold shock
BcFMB_RS05825	COG1196	nuclear chromosome segregation
BcFMB_RS05840	COG2945	thiolester hydrolase activity
BcFMB_RS05845	COG1126	abc transporter atp-binding protein
BcFMB_RS05850	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BcFMB_RS05855	COG0765	amino acid transport
BcFMB_RS05860	COG0765	amino acid transport
BcFMB_RS05865	COG2326	polyphosphate kinase activity
BcFMB_RS05880	COG2814	Major facilitator Superfamily
BcFMB_RS05915	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
BcFMB_RS05925	COG0656	L-ascorbic acid biosynthetic process
BcFMB_RS05935	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
BcFMB_RS05955	COG1122	ATPase activity
BcFMB_RS05975	COG0489	protein tyrosine kinase activity
BcFMB_RS05975	COG2151	metal-sulfur cluster biosynthetic enzyme
BcFMB_RS05985	COG4721	ABC-type cobalt transport system, permease component
BcFMB_RS06020	COG2197	response regulator
BcFMB_RS06020	COG3903	Transcriptional regulator
BcFMB_RS06025	COG4721	ABC-type cobalt transport system, permease component
BcFMB_RS06040	COG1136	(ABC) transporter
BcFMB_RS06045	COG0577	efflux transmembrane transporter activity
BcFMB_RS06050	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BcFMB_RS06140	COG0569	domain protein
BcFMB_RS06145	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BcFMB_RS06160	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BcFMB_RS06180	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BcFMB_RS06200	COG0799	negative regulation of ribosome biogenesis
BcFMB_RS06205	COG0406	alpha-ribazole phosphatase activity
BcFMB_RS06230	COG0406	alpha-ribazole phosphatase activity
BcFMB_RS06235	COG0598	Magnesium transport protein CorA
BcFMB_RS06265	COG0802	atpase or kinase
BcFMB_RS06275	COG0456	acetyltransferase
BcFMB_RS06400	COG1192	Involved in chromosome partitioning
BcFMB_RS06565	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BcFMB_RS06565	COG0551	DNA topoisomerase type I activity
BcFMB_RS06600	COG3177	Filamentation induced by cAMP protein fic
BcFMB_RS06630	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BcFMB_RS06635	COG0280	phosphate acetyltransferase
BcFMB_RS06635	COG0857	belongs to the CobB CobQ family
BcFMB_RS06665	COG1373	ATPase (AAA superfamily
BcFMB_RS06670	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
BcFMB_RS06680	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
BcFMB_RS06775	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BcFMB_RS06805	COG1523	belongs to the glycosyl hydrolase 13 family
BcFMB_RS06820	COG1136	(ABC) transporter
BcFMB_RS06825	COG3620	sequence-specific DNA binding
BcFMB_RS06835	COG1376	ErfK ybiS ycfS ynhG family protein
BcFMB_RS06850	COG0396	ATPase activity
BcFMB_RS06860	COG0822	iron-sulfur transferase activity
BcFMB_RS06865	COG2151	metal-sulfur cluster biosynthetic enzyme
BcFMB_RS06885	COG0537	adenosine 5'-monophosphoramidase activity
BcFMB_RS06915	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
BcFMB_RS06945	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BcFMB_RS06950	COG2860	membrane
BcFMB_RS06970	COG0069	glutamate synthase activity
BcFMB_RS06970	COG0070	glutamate synthase
BcFMB_RS06970	COG0067	glutamate synthase
BcFMB_RS06990	COG1119	ATPase activity
BcFMB_RS07010	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BcFMB_RS07030	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BcFMB_RS07035	COG0284	orotidine-5'-phosphate decarboxylase activity
BcFMB_RS07045	COG0167	dihydroorotate dehydrogenase activity
BcFMB_RS07060	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BcFMB_RS07100	COG0210	DNA helicase
BcFMB_RS07135	COG1733	regulation of RNA biosynthetic process
BcFMB_RS07150	COG0583	DNA-binding transcription factor activity
BcFMB_RS07190	COG0488	(ABC) transporter
BcFMB_RS07215	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BcFMB_RS07240	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BcFMB_RS07245	COG0561	phosphatase activity
BcFMB_RS07255	COG0436	Aminotransferase
BcFMB_RS07265	COG0436	Aminotransferase
BcFMB_RS07275	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BcFMB_RS07335	COG2188	Transcriptional regulator
BcFMB_RS07340	COG1131	(ABC) transporter
BcFMB_RS07360	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BcFMB_RS07370	COG0456	acetyltransferase
BcFMB_RS07380	COG0488	(ABC) transporter
BcFMB_RS07400	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BcFMB_RS07405	COG1560	Kdo2-lipid A biosynthetic process
BcFMB_RS07410	COG0438	transferase activity, transferring glycosyl groups
BcFMB_RS07435	COG1862	Preprotein translocase
BcFMB_RS07445	COG0045	succinate-CoA ligase (ADP-forming) activity
BcFMB_RS07515	COG0546	phosphoglycolate phosphatase activity
BcFMB_RS07540	COG1716	ATPase activity
BcFMB_RS07560	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BcFMB_RS07575	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BcFMB_RS07590	COG0133	tryptophan synthase activity
BcFMB_RS07600	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
BcFMB_RS07685	COG1022	Amp-dependent synthetase and ligase
BcFMB_RS07695	COG0516	GMP reductase activity
BcFMB_RS07870	COG3617	BRO family, N-terminal domain
BcFMB_RS08010	COG0469	pyruvate kinase activity
BcFMB_RS08025	COG0237	dephospho-CoA kinase activity
BcFMB_RS08030	COG0539	negative regulation of cytoplasmic translation
BcFMB_RS08045	COG1121	(ABC) transporter
BcFMB_RS08060	COG1329	Transcriptional regulator
BcFMB_RS08070	COG0745	RESPONSE REGULATOR receiver
BcFMB_RS08075	COG2205	protein histidine kinase activity
BcFMB_RS08105	COG1316	TRANSCRIPTIONal
BcFMB_RS08110	COG1316	TRANSCRIPTIONal
BcFMB_RS08115	COG1674	ftsk spoiiie
BcFMB_RS08135	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BcFMB_RS08145	COG1760	l-serine dehydratase
BcFMB_RS08185	COG1116	anion transmembrane transporter activity
BcFMB_RS08215	COG2879	small protein
BcFMB_RS08225	COG1132	(ABC) transporter
BcFMB_RS08285	COG1918	ferrous iron import across plasma membrane
BcFMB_RS08285	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
BcFMB_RS08305	COG0363	glucosamine-6-phosphate deaminase activity
BcFMB_RS08310	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BcFMB_RS08330	COG1028	Short-chain dehydrogenase reductase Sdr
BcFMB_RS08335	COG0513	Belongs to the DEAD box helicase family
BcFMB_RS08340	COG2233	PERMEase
BcFMB_RS08365	COG0012	GTP binding
BcFMB_RS08370	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BcFMB_RS08380	COG4585	Histidine kinase
BcFMB_RS08385	COG2197	response regulator
BcFMB_RS08395	COG0577	efflux transmembrane transporter activity
BcFMB_RS08395	COG1136	(ABC) transporter
BcFMB_RS08400	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
BcFMB_RS08405	COG1122	ATPase activity
BcFMB_RS08410	COG2873	o-acetylhomoserine
BcFMB_RS08435	COG1053	succinate dehydrogenase
BcFMB_RS08460	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
BcFMB_RS08525	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
BcFMB_RS08530	COG1882	Formate acetyltransferase
BcFMB_RS08540	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BcFMB_RS08540	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BcFMB_RS08545	COG1473	amidohydrolase
BcFMB_RS08550	COG2011	ABC-type metal ion transport system permease component
BcFMB_RS08560	COG1464	Belongs to the NlpA lipoprotein family
BcFMB_RS08575	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BcFMB_RS08615	COG1716	ATPase activity
BcFMB_RS08615	COG1131	(ABC) transporter
BcFMB_RS08615	COG0842	Transport permease protein
BcFMB_RS08625	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BcFMB_RS08630	COG4975	Glucose uptake
BcFMB_RS08635	COG1201	RNA secondary structure unwinding
BcFMB_RS08650	COG0187	DNA topoisomerase II activity
BcFMB_RS08655	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BcFMB_RS08665	COG0142	geranyltranstransferase activity
BcFMB_RS08685	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BcFMB_RS08695	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
BcFMB_RS08705	COG2137	regulation of response to DNA damage stimulus
BcFMB_RS08720	COG1396	sequence-specific DNA binding
BcFMB_RS08725	COG1546	Belongs to the CinA family
BcFMB_RS08725	COG1058	Belongs to the CinA family
BcFMB_RS08730	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BcFMB_RS08750	COG2357	RelA SpoT domain protein
BcFMB_RS08755	COG0670	Belongs to the BI1 family
BcFMB_RS08760	COG3804	dihydrodipicolinate reductase
BcFMB_RS08775	COG2197	response regulator
BcFMB_RS08780	COG4585	Histidine kinase
BcFMB_RS08785	COG1131	(ABC) transporter
BcFMB_RS08805	COG1335	isochorismatase
BcFMB_RS08810	COG0110	maltose O-acetyltransferase activity
BcFMB_RS08820	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
BcFMB_RS08840	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BcFMB_RS08895	COG0708	Exodeoxyribonuclease III
BcFMB_RS08905	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BcFMB_RS08910	COG0601	transmembrane transport
BcFMB_RS08920	COG4166	transmembrane transport
BcFMB_RS08930	COG1136	(ABC) transporter
BcFMB_RS08930	COG4591	ABC-type transport system involved in lipoprotein release permease component
BcFMB_RS08935	COG0577	efflux transmembrane transporter activity
BcFMB_RS08945	COG0287	Prephenate dehydrogenase
BcFMB_RS08950	COG0077	Prephenate dehydratase
BcFMB_RS08960	COG1217	gtp-binding protein TYPA
BcFMB_RS08965	COG0477	Major facilitator Superfamily
BcFMB_RS08995	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BcFMB_RS09020	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BcFMB_RS09060	COG0285	dihydrofolate synthase activity
BcFMB_RS09095	COG0006	proline dipeptidase activity
BcFMB_RS09100	COG2816	NAD+ diphosphatase activity
BcFMB_RS09150	COG3189	MarR family transcriptional regulator
BcFMB_RS09185	COG4608	Belongs to the ABC transporter superfamily
BcFMB_RS09190	COG0601	transmembrane transport