locus-tag	class	description
BBDE_RS00010	COG0592	DNA-directed DNA polymerase activity
BBDE_RS00025	COG0187	DNA topoisomerase II activity
BBDE_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BBDE_RS00040	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BBDE_RS00045	COG1609	Transcriptional regulator
BBDE_RS00060	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BBDE_RS00065	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
BBDE_RS00075	COG1970	mechanosensitive ion channel activity
BBDE_RS00100	COG0783	Belongs to the Dps family
BBDE_RS00105	COG1253	flavin adenine dinucleotide binding
BBDE_RS00120	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
BBDE_RS00130	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BBDE_RS00135	COG0180	Tryptophanyl-tRNA synthetase
BBDE_RS00150	COG0058	SHG alpha-glucan phosphorylase activity
BBDE_RS00180	COG3764	Sortase (surface protein transpeptidase)
BBDE_RS00195	COG0515	serine threonine protein kinase
BBDE_RS00200	COG0768	penicillin binding
BBDE_RS00245	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
BBDE_RS00255	COG2910	NAD(P)H-binding
BBDE_RS00260	COG1733	regulation of RNA biosynthetic process
BBDE_RS00270	COG0343	queuine tRNA-ribosyltransferase activity
BBDE_RS00280	COG2217	Heavy metal translocating P-type atpase
BBDE_RS00285	COG0252	asparaginase activity
BBDE_RS00290	COG1113	amino acid transport
BBDE_RS00350	COG2409	Drug exporters of the RND superfamily
BBDE_RS00385	COG3843	relaxase mobilization nuclease domain protein
BBDE_RS00415	COG0191	fructose-bisphosphate aldolase activity
BBDE_RS00490	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
BBDE_RS00495	COG1984	allophanate hydrolase subunit 2
BBDE_RS00500	COG4770	biotin carboxylase activity
BBDE_RS00550	COG0477	Major facilitator Superfamily
BBDE_RS00570	COG2801	Transposase and inactivated derivatives
BBDE_RS00595	COG1175	transmembrane transport
BBDE_RS00610	COG1609	Transcriptional regulator
BBDE_RS00635	COG1113	amino acid transport
BBDE_RS00645	COG1653	transport
BBDE_RS00655	COG0395	ABC-type sugar transport system, permease component
BBDE_RS00690	COG1113	amino acid transport
BBDE_RS00715	COG1846	Transcriptional regulator
BBDE_RS00755	COG3250	beta-galactosidase activity
BBDE_RS00765	COG0672	)-iron permease
BBDE_RS00770	COG3470	protein probably involved in high-affinity Fe2 transport
BBDE_RS00785	COG0577	efflux transmembrane transporter activity
BBDE_RS00800	COG1609	Transcriptional regulator
BBDE_RS00805	COG1609	Transcriptional regulator
BBDE_RS00810	COG1129	ABC transporter
BBDE_RS00815	COG1172	Belongs to the binding-protein-dependent transport system permease family
BBDE_RS00820	COG1879	ABC-type sugar transport system periplasmic component
BBDE_RS00825	COG1869	D-ribose catabolic process
BBDE_RS00860	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
BBDE_RS00880	COG1215	transferase activity, transferring glycosyl groups
BBDE_RS00885	COG1309	transcriptional regulator
BBDE_RS00910	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
BBDE_RS00920	COG0305	Participates in initiation and elongation during chromosome replication
BBDE_RS00925	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BBDE_RS00965	COG0584	glycerophosphoryl diester phosphodiesterase
BBDE_RS00980	COG0406	alpha-ribazole phosphatase activity
BBDE_RS00980	COG0494	nUDIX hydrolase
BBDE_RS00985	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BBDE_RS00990	COG1309	transcriptional regulator
BBDE_RS00995	COG1472	Belongs to the glycosyl hydrolase 3 family
BBDE_RS01000	COG2211	Major facilitator Superfamily
BBDE_RS01045	COG3279	Response regulator of the LytR AlgR family
BBDE_RS01065	COG3250	beta-galactosidase activity
BBDE_RS01080	COG1309	transcriptional regulator
BBDE_RS01085	COG2169	Transcriptional regulator
BBDE_RS01135	COG3507	Belongs to the glycosyl hydrolase 43 family
BBDE_RS01145	COG1609	Transcriptional regulator
BBDE_RS01150	COG3940	Belongs to the glycosyl hydrolase 43 family
BBDE_RS01160	COG4209	transmembrane transport
BBDE_RS01165	COG0395	ABC-type sugar transport system, permease component
BBDE_RS01175	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BBDE_RS01180	COG1260	myo-inositol-1-phosphate synthase
BBDE_RS01195	COG1754	DNA topoisomerase type I activity
BBDE_RS01195	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BBDE_RS01205	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BBDE_RS01210	COG1609	Transcriptional regulator
BBDE_RS01220	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BBDE_RS01265	COG3152	Membrane
BBDE_RS01320	COG0745	RESPONSE REGULATOR receiver
BBDE_RS01320	COG2972	Histidine kinase
BBDE_RS01325	COG0167	dihydroorotate dehydrogenase activity
BBDE_RS01330	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BBDE_RS01390	COG3842	ATPase activity
BBDE_RS01430	COG0436	Aminotransferase
BBDE_RS01435	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
BBDE_RS01445	COG3265	gluconokinase activity
BBDE_RS01465	COG2270	Major facilitator Superfamily
BBDE_RS01485	COG0742	ribosomal rna small subunit methyltransferase
BBDE_RS01495	COG1027	Aspartate ammonia-lyase
BBDE_RS01505	COG1837	Belongs to the UPF0109 family
BBDE_RS01530	COG0519	Catalyzes the synthesis of GMP from XMP
BBDE_RS01535	COG0488	(ABC) transporter
BBDE_RS01580	COG0667	Aldo Keto reductase
BBDE_RS01585	COG0789	Transcriptional regulator
BBDE_RS01640	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BBDE_RS01645	COG1136	(ABC) transporter
BBDE_RS01660	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BBDE_RS01665	COG1530	ribonuclease E activity
BBDE_RS01690	COG0436	Aminotransferase
BBDE_RS01705	COG0250	Participates in transcription elongation, termination and antitermination
BBDE_RS01735	COG1268	BioY protein
BBDE_RS01740	COG4770	biotin carboxylase activity
BBDE_RS01745	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BBDE_RS01785	COG1704	LemA family
BBDE_RS01805	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BBDE_RS01810	COG0531	amino acid
BBDE_RS01820	COG0826	peptidase U32
BBDE_RS01835	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
BBDE_RS01845	COG3579	cysteine-type endopeptidase activity
BBDE_RS01850	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BBDE_RS01855	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BBDE_RS01860	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BBDE_RS01865	COG5002	protein histidine kinase activity
BBDE_RS01870	COG0745	RESPONSE REGULATOR receiver
BBDE_RS01900	COG2252	PERMEase
BBDE_RS01915	COG0534	Mate efflux family protein
BBDE_RS01945	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BBDE_RS01965	COG0626	cystathionine gamma-synthase activity
BBDE_RS01990	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BBDE_RS01995	COG0531	amino acid
BBDE_RS02010	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BBDE_RS02030	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BBDE_RS02035	COG1739	Uncharacterized protein family UPF0029
BBDE_RS02080	COG1012	belongs to the aldehyde dehydrogenase family
BBDE_RS02080	COG1454	alcohol dehydrogenase
BBDE_RS02135	COG0255	Belongs to the universal ribosomal protein uL29 family
BBDE_RS02240	COG2308	Evidence 4 Homologs of previously reported genes of
BBDE_RS02280	COG0196	riboflavin kinase activity
BBDE_RS02285	COG1126	abc transporter atp-binding protein
BBDE_RS02290	COG0765	amino acid transport
BBDE_RS02295	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BBDE_RS02305	COG0402	S-adenosylhomocysteine deaminase activity
BBDE_RS02310	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
BBDE_RS02330	COG0328	RNA-DNA hybrid ribonuclease activity
BBDE_RS02335	COG3290	protein histidine kinase activity
BBDE_RS02355	COG3711	transcriptional antiterminator
BBDE_RS02360	COG1803	Methylglyoxal synthase
BBDE_RS02360	COG1597	lipid kinase activity
BBDE_RS02390	COG1175	transmembrane transport
BBDE_RS02395	COG0395	ABC-type sugar transport system, permease component
BBDE_RS02400	COG1609	Transcriptional regulator
BBDE_RS02410	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BBDE_RS02420	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
BBDE_RS02460	COG1132	(ABC) transporter
BBDE_RS02460	COG2375	cellular response to nickel ion
BBDE_RS02465	COG2814	Major facilitator Superfamily
BBDE_RS02495	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BBDE_RS02515	COG4716	Myosin-crossreactive antigen
BBDE_RS02520	COG0704	Plays a role in the regulation of phosphate uptake
BBDE_RS02525	COG5002	protein histidine kinase activity
BBDE_RS02540	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BBDE_RS02545	COG3942	CHAP domain
BBDE_RS02545	COG1705	Flagellar rod assembly protein muramidase FlgJ
BBDE_RS02550	COG0791	NLP P60 protein
BBDE_RS02555	COG0589	response to stress
BBDE_RS02595	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BBDE_RS02640	COG1454	alcohol dehydrogenase
BBDE_RS02680	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
BBDE_RS02685	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BBDE_RS02700	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BBDE_RS02710	COG1946	Acyl-CoA thioesterase
BBDE_RS02725	COG0242	peptide deformylase activity
BBDE_RS02740	COG2873	o-acetylhomoserine
BBDE_RS02750	COG3507	Belongs to the glycosyl hydrolase 43 family
BBDE_RS02755	COG1609	Transcriptional regulator
BBDE_RS02760	COG1653	transport
BBDE_RS02765	COG1175	transmembrane transport
BBDE_RS02775	COG3507	Belongs to the glycosyl hydrolase 43 family
BBDE_RS02785	COG4213	ABC transporter substrate-binding protein
BBDE_RS02790	COG1129	ABC transporter
BBDE_RS02795	COG4214	carbohydrate transport
BBDE_RS02810	COG1070	Carbohydrate kinase
BBDE_RS02930	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
BBDE_RS02980	COG0009	L-threonylcarbamoyladenylate synthase
BBDE_RS02985	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BBDE_RS03040	COG1609	Transcriptional regulator
BBDE_RS03045	COG0366	Alpha amylase catalytic
BBDE_RS03065	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BBDE_RS03085	COG3590	peptidase
BBDE_RS03095	COG0024	Methionine aminopeptidase
BBDE_RS03115	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BBDE_RS03120	COG2884	Cell division ATP-binding protein ftsE
BBDE_RS03125	COG2177	Part of the ABC transporter FtsEX involved in
BBDE_RS03130	COG1388	LysM domain
BBDE_RS03130	COG3942	CHAP domain
BBDE_RS03145	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BBDE_RS03160	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BBDE_RS03175	COG1653	transport
BBDE_RS03185	COG1609	Transcriptional regulator
BBDE_RS03190	COG1175	transmembrane transport
BBDE_RS03195	COG0395	ABC-type sugar transport system, permease component
BBDE_RS03205	COG3534	alpha-L-arabinofuranosidase
BBDE_RS03210	COG1653	transport
BBDE_RS03225	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BBDE_RS03230	COG0747	negative chemotaxis
BBDE_RS03235	COG0601	transmembrane transport
BBDE_RS03240	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BBDE_RS03250	COG4608	Belongs to the ABC transporter superfamily
BBDE_RS03270	COG0514	ATP-dependent DNA helicase (RecQ)
BBDE_RS03285	COG0531	amino acid
BBDE_RS03290	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BBDE_RS03350	COG0765	amino acid transport
BBDE_RS03355	COG0765	amino acid transport
BBDE_RS03360	COG1126	abc transporter atp-binding protein
BBDE_RS03365	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BBDE_RS03370	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BBDE_RS03390	COG2011	ABC-type metal ion transport system permease component
BBDE_RS03395	COG0436	Aminotransferase
BBDE_RS03400	COG0626	cystathionine gamma-synthase activity
BBDE_RS03405	COG1126	abc transporter atp-binding protein
BBDE_RS03410	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BBDE_RS03415	COG0765	amino acid transport
BBDE_RS03420	COG1454	alcohol dehydrogenase
BBDE_RS03425	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BBDE_RS03430	COG2011	ABC-type metal ion transport system permease component
BBDE_RS03445	COG0371	Dehydrogenase
BBDE_RS03460	COG0577	efflux transmembrane transporter activity
BBDE_RS03460	COG1136	(ABC) transporter
BBDE_RS03470	COG0577	efflux transmembrane transporter activity
BBDE_RS03475	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BBDE_RS03485	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BBDE_RS03490	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BBDE_RS03520	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BBDE_RS03565	COG0385	Bile acid
BBDE_RS03610	COG0284	orotidine-5'-phosphate decarboxylase activity
BBDE_RS03625	COG2801	Transposase and inactivated derivatives
BBDE_RS03645	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BBDE_RS03660	COG0560	Phosphoserine phosphatase
BBDE_RS03665	COG1222	aaa ATPase
BBDE_RS03670	COG4122	O-methyltransferase activity
BBDE_RS03685	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
BBDE_RS03710	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BBDE_RS03750	COG0714	Associated with various cellular activities
BBDE_RS03780	COG0745	RESPONSE REGULATOR receiver
BBDE_RS03785	COG2205	protein histidine kinase activity
BBDE_RS03800	COG0589	response to stress
BBDE_RS03815	COG1196	nuclear chromosome segregation
BBDE_RS03830	COG0765	amino acid transport
BBDE_RS03840	COG1126	abc transporter atp-binding protein
BBDE_RS03845	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BBDE_RS03850	COG0765	amino acid transport
BBDE_RS03855	COG0765	amino acid transport
BBDE_RS03860	COG2326	polyphosphate kinase activity
BBDE_RS03875	COG2814	Major facilitator Superfamily
BBDE_RS03880	COG4166	transmembrane transport
BBDE_RS03920	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BBDE_RS03925	COG1053	succinate dehydrogenase
BBDE_RS03930	COG0758	DNA mediated transformation
BBDE_RS03930	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BBDE_RS03950	COG2873	o-acetylhomoserine
BBDE_RS03960	COG1122	ATPase activity
BBDE_RS03965	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
BBDE_RS03975	COG1136	(ABC) transporter
BBDE_RS03980	COG1136	(ABC) transporter
BBDE_RS03980	COG0577	efflux transmembrane transporter activity
BBDE_RS03985	COG2197	response regulator
BBDE_RS03990	COG4585	Histidine kinase
BBDE_RS04000	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BBDE_RS04005	COG0012	GTP binding
BBDE_RS04010	COG2188	Transcriptional regulator
BBDE_RS04040	COG0583	DNA-binding transcription factor activity
BBDE_RS04065	COG2207	Transcriptional regulator
BBDE_RS04065	COG1917	Cupin 2, conserved barrel domain protein
BBDE_RS04075	COG2233	PERMEase
BBDE_RS04080	COG4221	oxidoreductase activity
BBDE_RS04090	COG0390	transport system, permease component
BBDE_RS04095	COG1132	(ABC) transporter
BBDE_RS04100	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
BBDE_RS04105	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
BBDE_RS04110	COG3340	Belongs to the peptidase S51 family
BBDE_RS04115	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BBDE_RS04120	COG0363	glucosamine-6-phosphate deaminase activity
BBDE_RS04140	COG1028	Short-chain dehydrogenase reductase Sdr
BBDE_RS04145	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BBDE_RS04165	COG0583	DNA-binding transcription factor activity
BBDE_RS04175	COG2249	NAD(P)H dehydrogenase (quinone) activity
BBDE_RS04180	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
BBDE_RS04185	COG1687	branched-chain amino acid
BBDE_RS04190	COG1966	Carbon starvation protein
BBDE_RS04245	COG1760	l-serine dehydratase
BBDE_RS04255	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BBDE_RS04280	COG1316	TRANSCRIPTIONal
BBDE_RS04285	COG1316	TRANSCRIPTIONal
BBDE_RS04315	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BBDE_RS04320	COG2205	protein histidine kinase activity
BBDE_RS04325	COG0745	RESPONSE REGULATOR receiver
BBDE_RS04335	COG1329	Transcriptional regulator
BBDE_RS04350	COG1121	(ABC) transporter
BBDE_RS04365	COG0539	negative regulation of cytoplasmic translation
BBDE_RS04385	COG0469	pyruvate kinase activity
BBDE_RS04390	COG0494	nUDIX hydrolase
BBDE_RS04450	COG3177	Filamentation induced by cAMP protein fic
BBDE_RS04545	COG2176	DNA-directed DNA polymerase activity
BBDE_RS04545	COG5002	protein histidine kinase activity
BBDE_RS04550	COG0629	single-stranded DNA binding
BBDE_RS04625	COG1175	transmembrane transport
BBDE_RS04815	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BBDE_RS04820	COG0494	nUDIX hydrolase
BBDE_RS04855	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BBDE_RS04870	COG2197	response regulator
BBDE_RS04895	COG0857	belongs to the CobB CobQ family
BBDE_RS04895	COG0280	phosphate acetyltransferase
BBDE_RS04900	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BBDE_RS04905	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
BBDE_RS04905	COG2755	lipolytic protein G-D-S-L family
BBDE_RS04935	COG1136	(ABC) transporter
BBDE_RS04995	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BBDE_RS05000	COG1523	belongs to the glycosyl hydrolase 13 family
BBDE_RS05015	COG0719	Fe-S assembly protein
BBDE_RS05020	COG0396	ATPase activity
BBDE_RS05025	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BBDE_RS05035	COG2151	metal-sulfur cluster biosynthetic enzyme
BBDE_RS05060	COG0537	adenosine 5'-monophosphoramidase activity
BBDE_RS05090	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
BBDE_RS05110	COG1309	transcriptional regulator
BBDE_RS05125	COG0534	Mate efflux family protein
BBDE_RS05130	COG0667	Aldo Keto reductase
BBDE_RS05140	COG1136	(ABC) transporter
BBDE_RS05140	COG0577	efflux transmembrane transporter activity
BBDE_RS05165	COG2508	Transcriptional regulator
BBDE_RS05170	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BBDE_RS05180	COG1454	alcohol dehydrogenase
BBDE_RS05205	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BBDE_RS05210	COG2860	membrane
BBDE_RS05230	COG0069	glutamate synthase activity
BBDE_RS05230	COG0070	glutamate synthase
BBDE_RS05230	COG0067	glutamate synthase
BBDE_RS05245	COG0297	glycogen (starch) synthase activity
BBDE_RS05250	COG1119	ATPase activity
BBDE_RS05270	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BBDE_RS05300	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BBDE_RS05305	COG0284	orotidine-5'-phosphate decarboxylase activity
BBDE_RS05310	COG0543	2 iron, 2 sulfur cluster binding
BBDE_RS05315	COG0167	dihydroorotate dehydrogenase activity
BBDE_RS05335	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
BBDE_RS05345	COG1136	(ABC) transporter
BBDE_RS05345	COG0577	efflux transmembrane transporter activity
BBDE_RS05355	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BBDE_RS05355	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
BBDE_RS05360	COG1136	(ABC) transporter
BBDE_RS05360	COG0577	efflux transmembrane transporter activity
BBDE_RS05385	COG1063	alcohol dehydrogenase
BBDE_RS05395	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BBDE_RS05410	COG0488	(ABC) transporter
BBDE_RS05415	COG1122	ATPase activity
BBDE_RS05420	COG1335	isochorismatase
BBDE_RS05430	COG0488	(ABC) transporter
BBDE_RS05435	COG0281	malic enzyme
BBDE_RS05525	COG2801	Transposase and inactivated derivatives
BBDE_RS05535	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BBDE_RS05545	COG0436	Aminotransferase
BBDE_RS05550	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BBDE_RS05610	COG1716	ATPase activity
BBDE_RS05635	COG4581	dead DEAH box helicase
BBDE_RS05675	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BBDE_RS05695	COG0045	succinate-CoA ligase (ADP-forming) activity
BBDE_RS05730	COG0438	transferase activity, transferring glycosyl groups
BBDE_RS05735	COG1560	Kdo2-lipid A biosynthetic process
BBDE_RS05740	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BBDE_RS05765	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BBDE_RS05780	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BBDE_RS05795	COG0133	tryptophan synthase activity
BBDE_RS05860	COG0516	GMP reductase activity
BBDE_RS05875	COG1022	Amp-dependent synthetase and ligase
BBDE_RS05900	COG0456	acetyltransferase
BBDE_RS05910	COG0802	atpase or kinase
BBDE_RS05925	COG1555	photosystem II stabilization
BBDE_RS05925	COG1596	polysaccharide export
BBDE_RS05940	COG0598	Magnesium transport protein CorA
BBDE_RS05965	COG3275	phosphorelay sensor kinase activity
BBDE_RS05970	COG3279	Response regulator of the LytR AlgR family
BBDE_RS05990	COG0406	alpha-ribazole phosphatase activity
BBDE_RS05995	COG0799	negative regulation of ribosome biogenesis
BBDE_RS06055	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
BBDE_RS06120	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BBDE_RS06135	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BBDE_RS06165	COG1609	Transcriptional regulator
BBDE_RS06175	COG1175	transmembrane transport
BBDE_RS06180	COG0395	ABC-type sugar transport system, permease component
BBDE_RS06205	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BBDE_RS06210	COG0497	DNA recombination
BBDE_RS06220	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BBDE_RS06225	COG0569	domain protein
BBDE_RS06325	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BBDE_RS06330	COG0577	efflux transmembrane transporter activity
BBDE_RS06335	COG1136	(ABC) transporter
BBDE_RS06350	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BBDE_RS06400	COG0477	Major facilitator Superfamily
BBDE_RS06430	COG1611	Belongs to the LOG family
BBDE_RS06440	COG1122	ATPase activity
BBDE_RS06475	COG1122	ATPase activity
BBDE_RS06500	COG1228	amidohydrolase
BBDE_RS06510	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
BBDE_RS06535	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BBDE_RS06550	COG3189	MarR family transcriptional regulator
BBDE_RS06570	COG1028	Short-chain dehydrogenase reductase Sdr
BBDE_RS06580	COG1063	alcohol dehydrogenase
BBDE_RS06600	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
BBDE_RS06605	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
BBDE_RS06610	COG2267	carboxylic ester hydrolase activity
BBDE_RS06615	COG0110	maltose O-acetyltransferase activity
BBDE_RS06650	COG1250	3-hydroxyacyl-CoA dehydrogenase
BBDE_RS06660	COG1199	ATP-dependent helicase activity
BBDE_RS06660	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BBDE_RS06685	COG1882	Formate acetyltransferase
BBDE_RS06690	COG1929	Belongs to the glycerate kinase type-1 family
BBDE_RS06695	COG2610	gluconate transmembrane transporter activity
BBDE_RS06700	COG3835	regulator
BBDE_RS06715	COG1473	amidohydrolase
BBDE_RS06720	COG2011	ABC-type metal ion transport system permease component
BBDE_RS06730	COG1464	Belongs to the NlpA lipoprotein family
BBDE_RS06735	COG0561	phosphatase activity
BBDE_RS06770	COG2801	Transposase and inactivated derivatives
BBDE_RS06775	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BBDE_RS06780	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BBDE_RS06805	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BBDE_RS06810	COG1201	RNA secondary structure unwinding
BBDE_RS06815	COG3655	Transcriptional regulator
BBDE_RS06835	COG0187	DNA topoisomerase II activity
BBDE_RS06840	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BBDE_RS06850	COG0142	geranyltranstransferase activity
BBDE_RS06870	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BBDE_RS06880	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
BBDE_RS06885	COG2137	regulation of response to DNA damage stimulus
BBDE_RS06900	COG1396	sequence-specific DNA binding
BBDE_RS06905	COG1546	Belongs to the CinA family
BBDE_RS06905	COG1058	Belongs to the CinA family
BBDE_RS06910	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BBDE_RS06940	COG2357	RelA SpoT domain protein
BBDE_RS06950	COG0670	Belongs to the BI1 family
BBDE_RS06960	COG2197	response regulator
BBDE_RS06965	COG4585	Histidine kinase
BBDE_RS06970	COG1131	(ABC) transporter
BBDE_RS06990	COG0110	maltose O-acetyltransferase activity
BBDE_RS06995	COG0534	Mate efflux family protein
BBDE_RS07000	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
BBDE_RS07175	COG0708	Exodeoxyribonuclease III
BBDE_RS07185	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BBDE_RS07190	COG0601	transmembrane transport
BBDE_RS07195	COG4166	transmembrane transport
BBDE_RS07200	COG0747	negative chemotaxis
BBDE_RS07210	COG1136	(ABC) transporter
BBDE_RS07210	COG0577	efflux transmembrane transporter activity
BBDE_RS07215	COG1136	(ABC) transporter
BBDE_RS07215	COG0577	efflux transmembrane transporter activity
BBDE_RS07225	COG0287	Prephenate dehydrogenase
BBDE_RS07240	COG1217	gtp-binding protein TYPA
BBDE_RS07250	COG2801	Transposase and inactivated derivatives
BBDE_RS07255	COG0477	Major facilitator Superfamily
BBDE_RS07285	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BBDE_RS07290	COG0367	asparagine synthase
BBDE_RS07305	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BBDE_RS07325	COG1595	DNA-templated transcription, initiation
BBDE_RS07345	COG1794	racemase activity, acting on amino acids and derivatives
BBDE_RS07350	COG0285	dihydrofolate synthase activity
BBDE_RS07355	COG0006	proline dipeptidase activity
BBDE_RS07375	COG0601	transmembrane transport
BBDE_RS07385	COG1940	carbohydrate kinase activity
BBDE_RS07390	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
BBDE_RS07390	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
BBDE_RS07425	COG0772	Belongs to the SEDS family
BBDE_RS07440	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BBDE_RS07450	COG0768	penicillin binding
BBDE_RS07475	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BBDE_RS07505	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BBDE_RS07510	COG2813	Specifically methylates the guanine in position
BBDE_RS07515	COG1643	Atp-dependent helicase
BBDE_RS07520	COG2814	Major facilitator Superfamily
BBDE_RS07530	COG0174	glutamine synthetase
BBDE_RS07535	COG1674	ftsk spoiiie
BBDE_RS07570	COG1404	Belongs to the peptidase S8 family
BBDE_RS07595	COG1404	Belongs to the peptidase S8 family
BBDE_RS07635	COG0587	DNA-directed DNA polymerase activity
BBDE_RS07670	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BBDE_RS07705	COG0352	thiamine-phosphate diphosphorylase activity
BBDE_RS07705	COG0351	phosphomethylpyrimidine kinase
BBDE_RS07735	COG2197	response regulator
BBDE_RS07745	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BBDE_RS07800	COG1733	regulation of RNA biosynthetic process
BBDE_RS07815	COG3480	Lon protease (S16) C-terminal proteolytic domain
BBDE_RS07840	COG0613	PHP domain protein
BBDE_RS07850	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BBDE_RS07865	COG2094	Belongs to the DNA glycosylase MPG family
BBDE_RS07890	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
BBDE_RS07895	COG1518	maintenance of DNA repeat elements
BBDE_RS07935	COG3250	beta-galactosidase activity
BBDE_RS07940	COG1609	Transcriptional regulator
BBDE_RS07945	COG2814	Major facilitator Superfamily
BBDE_RS07960	COG1132	(ABC) transporter
BBDE_RS07985	COG0673	inositol 2-dehydrogenase activity
BBDE_RS07995	COG2223	nitrite transmembrane transporter activity
BBDE_RS08000	COG1028	Short-chain dehydrogenase reductase Sdr
BBDE_RS08015	COG0477	Major facilitator Superfamily
BBDE_RS08025	COG2211	Major facilitator Superfamily
BBDE_RS08035	COG1309	transcriptional regulator
BBDE_RS08050	COG1309	transcriptional regulator
BBDE_RS08060	COG3279	Response regulator of the LytR AlgR family
BBDE_RS08070	COG3507	Belongs to the glycosyl hydrolase 43 family
BBDE_RS08105	COG1309	transcriptional regulator
BBDE_RS08120	COG1609	Transcriptional regulator
BBDE_RS08125	COG1028	Short-chain dehydrogenase reductase Sdr
BBDE_RS08130	COG2610	gluconate transmembrane transporter activity
BBDE_RS08150	COG1328	CTP reductase activity
BBDE_RS08150	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BBDE_RS08155	COG1570	exodeoxyribonuclease VII activity
BBDE_RS08160	COG1722	exodeoxyribonuclease VII activity
BBDE_RS08175	COG0702	epimerase
BBDE_RS08190	COG0395	ABC-type sugar transport system, permease component
BBDE_RS08195	COG1175	transmembrane transport
BBDE_RS08200	COG1653	transport
BBDE_RS08240	COG0248	Ppx GppA phosphatase
BBDE_RS08245	COG0436	Aminotransferase
BBDE_RS08260	COG0494	nUDIX hydrolase
BBDE_RS08365	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
BBDE_RS08425	COG0076	glutamate decarboxylase activity
BBDE_RS08430	COG0531	amino acid
BBDE_RS08450	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BBDE_RS08460	COG2807	transmembrane transport
BBDE_RS08470	COG1937	Protein conserved in bacteria
BBDE_RS08495	COG0210	DNA helicase
BBDE_RS08530	COG0714	Associated with various cellular activities
BBDE_RS08580	COG1194	a g-specific adenine glycosylase
BBDE_RS08585	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BBDE_RS08600	COG0477	Major facilitator Superfamily
BBDE_RS08610	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BBDE_RS08625	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
BBDE_RS08635	COG1349	DNA-binding transcription factor activity
BBDE_RS08640	COG1216	Glycosyl transferase, family 2
BBDE_RS08650	COG0167	dihydroorotate dehydrogenase activity
BBDE_RS08655	COG1902	pentaerythritol trinitrate reductase activity
BBDE_RS08660	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BBDE_RS08660	COG4499	WXG100 protein secretion system (Wss), protein YukC
BBDE_RS08670	COG0095	Lipoate-protein ligase
BBDE_RS08700	COG1376	ErfK ybiS ycfS ynhG family protein
BBDE_RS08720	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BBDE_RS08730	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BBDE_RS08745	COG0438	transferase activity, transferring glycosyl groups
BBDE_RS08755	COG1216	Glycosyl transferase, family 2
BBDE_RS08765	COG1216	Glycosyl transferase, family 2
BBDE_RS08765	COG1442	glycosyl transferase family 8
BBDE_RS08770	COG0463	Glycosyl transferase, family 2
BBDE_RS08810	COG1216	Glycosyl transferase, family 2
BBDE_RS08810	COG1442	glycosyl transferase family 8
BBDE_RS08825	COG1442	glycosyl transferase family 8
BBDE_RS08825	COG1216	Glycosyl transferase, family 2
BBDE_RS08840	COG1216	Glycosyl transferase, family 2
BBDE_RS08840	COG1442	glycosyl transferase family 8
BBDE_RS08855	COG1442	glycosyl transferase family 8
BBDE_RS08855	COG1216	Glycosyl transferase, family 2
BBDE_RS08860	COG1442	glycosyl transferase family 8
BBDE_RS08860	COG1216	Glycosyl transferase, family 2
BBDE_RS08865	COG0438	transferase activity, transferring glycosyl groups
BBDE_RS08880	COG1216	Glycosyl transferase, family 2
BBDE_RS08885	COG1442	glycosyl transferase family 8
BBDE_RS08885	COG1216	Glycosyl transferase, family 2
BBDE_RS08900	COG0438	transferase activity, transferring glycosyl groups
BBDE_RS08910	COG0489	protein tyrosine kinase activity
BBDE_RS08930	COG0489	protein tyrosine kinase activity
BBDE_RS08945	COG1088	dTDP-glucose 4,6-dehydratase activity
BBDE_RS08975	COG1028	Short-chain dehydrogenase reductase Sdr
BBDE_RS08980	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
BBDE_RS09020	COG3443	Belongs to the bacterial solute-binding protein 9 family
BBDE_RS09020	COG0803	Belongs to the bacterial solute-binding protein 9 family
BBDE_RS09030	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BBDE_RS09035	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BBDE_RS09040	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BBDE_RS09065	COG1136	(ABC) transporter
BBDE_RS09070	COG0577	efflux transmembrane transporter activity
BBDE_RS09075	COG0577	efflux transmembrane transporter activity
BBDE_RS09095	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BBDE_RS09105	COG2814	Major facilitator Superfamily
BBDE_RS09120	COG0656	L-ascorbic acid biosynthetic process
BBDE_RS09135	COG1609	Transcriptional regulator
BBDE_RS09145	COG0395	ABC-type sugar transport system, permease component
BBDE_RS09150	COG1175	transmembrane transport
BBDE_RS09170	COG4988	ABC transporter
BBDE_RS09180	COG0477	Major facilitator Superfamily
BBDE_RS09185	COG1609	Transcriptional regulator
BBDE_RS09210	COG1609	Transcriptional regulator
BBDE_RS09220	COG0083	homoserine kinase activity
BBDE_RS09225	COG0460	homoserine dehydrogenase
BBDE_RS09235	COG0019	diaminopimelate decarboxylase activity
BBDE_RS09245	COG0833	amino acid
BBDE_RS09250	COG0251	oxidation-reduction process
BBDE_RS09285	COG0545	Peptidyl-prolyl cis-trans isomerase
BBDE_RS09295	COG2801	Transposase and inactivated derivatives
BBDE_RS09305	COG1131	(ABC) transporter
BBDE_RS09340	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BBDE_RS09375	COG0356	it plays a direct role in the translocation of protons across the membrane
BBDE_RS09395	COG0679	Auxin Efflux Carrier
BBDE_RS09400	COG0028	Belongs to the TPP enzyme family
BBDE_RS09415	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BBDE_RS09430	COG0745	RESPONSE REGULATOR receiver
BBDE_RS09435	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BBDE_RS09440	COG0747	negative chemotaxis
BBDE_RS09455	COG0287	Prephenate dehydrogenase
BBDE_RS09455	COG1605	Chorismate mutase
BBDE_RS09460	COG1522	sequence-specific DNA binding
BBDE_RS09520	COG1322	Protein conserved in bacteria
BBDE_RS09535	COG0179	Fumarylacetoacetate (FAA) hydrolase
BBDE_RS09560	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BBDE_RS09580	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BBDE_RS09590	COG1122	ATPase activity
BBDE_RS09620	COG1131	(ABC) transporter
BBDE_RS09625	COG2197	response regulator
BBDE_RS09665	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BBDE_RS09690	COG1368	sulfuric ester hydrolase activity
BBDE_RS09700	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
BBDE_RS09715	COG3754	Rhamnan synthesis protein F
BBDE_RS09730	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BBDE_RS09750	COG1216	Glycosyl transferase, family 2
BBDE_RS09755	COG3177	Filamentation induced by cAMP protein fic
BBDE_RS09795	COG1216	Glycosyl transferase, family 2
BBDE_RS09800	COG3867	Arabinogalactan endo-beta-1,4-galactanase
BBDE_RS09805	COG3594	Acyltransferase
BBDE_RS09820	COG0463	Glycosyl transferase, family 2
BBDE_RS09855	COG0701	Predicted permease
BBDE_RS09870	COG4214	carbohydrate transport
BBDE_RS09880	COG4213	ABC transporter substrate-binding protein
BBDE_RS09885	COG1940	carbohydrate kinase activity
BBDE_RS09890	COG1129	ABC transporter
BBDE_RS09945	COG0577	efflux transmembrane transporter activity
BBDE_RS09945	COG1136	(ABC) transporter
BBDE_RS09965	COG0084	hydrolase, TatD family'
BBDE_RS09985	COG1609	Transcriptional regulator
BBDE_RS09995	COG1879	ABC-type sugar transport system periplasmic component
BBDE_RS10000	COG1172	Belongs to the binding-protein-dependent transport system permease family
BBDE_RS10005	COG1129	ABC transporter
BBDE_RS10050	COG0395	ABC-type sugar transport system, permease component
BBDE_RS10055	COG4209	transmembrane transport
BBDE_RS10075	COG3250	beta-galactosidase activity
BBDE_RS10080	COG1132	(ABC) transporter
BBDE_RS10085	COG1132	(ABC) transporter
BBDE_RS10135	COG3459	Glycosyltransferase 36 associated
BBDE_RS10150	COG1609	Transcriptional regulator
BBDE_RS10160	COG1012	belongs to the aldehyde dehydrogenase family
BBDE_RS10165	COG1177	transmembrane transport
BBDE_RS10170	COG1176	ABC-type spermidine putrescine transport system, permease component I
BBDE_RS10175	COG1176	ABC-type spermidine putrescine transport system, permease component I
BBDE_RS10180	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
BBDE_RS10185	COG3842	ATPase activity
BBDE_RS10200	COG1454	alcohol dehydrogenase
BBDE_RS10205	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
BBDE_RS10225	COG3507	Belongs to the glycosyl hydrolase 43 family
BBDE_RS10230	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BBDE_RS10240	COG1501	Belongs to the glycosyl hydrolase 31 family
BBDE_RS10245	COG1472	Belongs to the glycosyl hydrolase 3 family
BBDE_RS10265	COG0395	ABC-type sugar transport system, permease component
BBDE_RS10270	COG4209	transmembrane transport
BBDE_RS10280	COG1501	Belongs to the glycosyl hydrolase 31 family
BBDE_RS10290	COG1175	transmembrane transport
BBDE_RS10295	COG1653	transport
BBDE_RS10300	COG1609	Transcriptional regulator
BBDE_RS10310	COG0395	ABC-type sugar transport system, permease component
BBDE_RS10320	COG1609	Transcriptional regulator
BBDE_RS10325	COG0586	Pfam SNARE associated Golgi protein
BBDE_RS10335	COG1373	ATPase (AAA superfamily
BBDE_RS10340	COG1609	Transcriptional regulator
BBDE_RS10355	COG0395	ABC-type sugar transport system, permease component
BBDE_RS10380	COG0789	Transcriptional regulator
BBDE_RS10400	COG1785	Belongs to the alkaline phosphatase family
BBDE_RS10405	COG1501	Belongs to the glycosyl hydrolase 31 family
BBDE_RS10410	COG0395	ABC-type sugar transport system, permease component
BBDE_RS10415	COG1175	transmembrane transport
BBDE_RS10425	COG1609	Transcriptional regulator
BBDE_RS10430	COG0730	response to heat
BBDE_RS10460	COG1609	Transcriptional regulator
BBDE_RS10475	COG1523	belongs to the glycosyl hydrolase 13 family
BBDE_RS10480	COG3833	ABC-type maltose transport systems, permease component
BBDE_RS10485	COG1175	transmembrane transport
BBDE_RS10505	COG0366	Alpha amylase catalytic
BBDE_RS10535	COG0406	alpha-ribazole phosphatase activity
BBDE_RS10550	COG3250	beta-galactosidase activity
BBDE_RS10565	COG0745	RESPONSE REGULATOR receiver
BBDE_RS10600	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BBDE_RS10605	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BBDE_RS10610	COG0366	Alpha amylase catalytic
BBDE_RS10615	COG0395	ABC-type sugar transport system, permease component
BBDE_RS10620	COG0395	ABC-type sugar transport system, permease component
BBDE_RS10625	COG1175	transmembrane transport
BBDE_RS10645	COG0037	tRNA processing
BBDE_RS10645	COG0590	tRNA wobble adenosine to inosine editing
BBDE_RS10650	COG0025	NhaP-type Na H and K H
BBDE_RS10665	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BBDE_RS10680	COG3842	ATPase activity
BBDE_RS10710	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BBDE_RS10710	COG1116	anion transmembrane transporter activity
BBDE_RS10715	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BBDE_RS10730	COG2186	Transcriptional regulator
BBDE_RS10735	COG0110	maltose O-acetyltransferase activity
BBDE_RS10740	COG0436	Aminotransferase
BBDE_RS10755	COG1472	Belongs to the glycosyl hydrolase 3 family
BBDE_RS10805	COG3583	domain protein
BBDE_RS10825	COG0617	tRNA 3'-terminal CCA addition
BBDE_RS10845	COG0028	Belongs to the TPP enzyme family
BBDE_RS10850	COG0492	ferredoxin-NADP+ reductase activity
BBDE_RS10860	COG1192	Involved in chromosome partitioning
BBDE_RS10870	COG1847	R3H domain protein