locus-tag	class	description
BINDI_RS00010	COG0592	DNA-directed DNA polymerase activity
BINDI_RS00025	COG0187	DNA topoisomerase II activity
BINDI_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BINDI_RS00035	COG3266	domain, Protein
BINDI_RS00060	COG1216	Glycosyl transferase, family 2
BINDI_RS00070	COG1472	Belongs to the glycosyl hydrolase 3 family
BINDI_RS00100	COG1136	(ABC) transporter
BINDI_RS00100	COG0577	efflux transmembrane transporter activity
BINDI_RS00115	COG1136	(ABC) transporter
BINDI_RS00115	COG0577	efflux transmembrane transporter activity
BINDI_RS00130	COG1129	ABC transporter
BINDI_RS00160	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BINDI_RS00190	COG0783	Belongs to the Dps family
BINDI_RS00195	COG1253	flavin adenine dinucleotide binding
BINDI_RS00200	COG0288	reversible hydration of carbon dioxide
BINDI_RS00215	COG1609	Transcriptional regulator
BINDI_RS00220	COG1653	transport
BINDI_RS00225	COG1175	transmembrane transport
BINDI_RS00230	COG0395	ABC-type sugar transport system, permease component
BINDI_RS00245	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
BINDI_RS00255	COG0180	Tryptophanyl-tRNA synthetase
BINDI_RS00275	COG0705	Rhomboid family
BINDI_RS00300	COG0515	serine threonine protein kinase
BINDI_RS00305	COG0768	penicillin binding
BINDI_RS00370	COG2217	Heavy metal translocating P-type atpase
BINDI_RS00375	COG1937	Protein conserved in bacteria
BINDI_RS00380	COG1301	dicarboxylic acid transport
BINDI_RS00390	COG0343	queuine tRNA-ribosyltransferase activity
BINDI_RS00435	COG0025	NhaP-type Na H and K H
BINDI_RS00440	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BINDI_RS00445	COG0037	tRNA processing
BINDI_RS00445	COG0590	tRNA wobble adenosine to inosine editing
BINDI_RS00455	COG0366	Alpha amylase catalytic
BINDI_RS00465	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BINDI_RS00470	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BINDI_RS00510	COG4989	oxidoreductase activity
BINDI_RS00520	COG0778	Nitroreductase
BINDI_RS00530	COG0406	alpha-ribazole phosphatase activity
BINDI_RS00540	COG1609	Transcriptional regulator
BINDI_RS00560	COG1609	Transcriptional regulator
BINDI_RS00585	COG0366	Alpha amylase catalytic
BINDI_RS00605	COG0789	Transcriptional regulator
BINDI_RS00635	COG0586	Pfam SNARE associated Golgi protein
BINDI_RS00680	COG0084	hydrolase, TatD family'
BINDI_RS00710	COG0395	ABC-type sugar transport system, permease component
BINDI_RS00720	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
BINDI_RS00725	COG3265	gluconokinase activity
BINDI_RS00755	COG0363	glucosamine-6-phosphate deaminase activity
BINDI_RS00790	COG0477	Major facilitator Superfamily
BINDI_RS00805	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BINDI_RS00810	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BINDI_RS00845	COG1733	regulation of RNA biosynthetic process
BINDI_RS00850	COG2910	NAD(P)H-binding
BINDI_RS00855	COG1288	antiporter activity
BINDI_RS00865	COG2188	Transcriptional regulator
BINDI_RS00870	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BINDI_RS00875	COG2222	sugar isomerase
BINDI_RS00885	COG2814	Major facilitator Superfamily
BINDI_RS00895	COG1914	H( )-stimulated, divalent metal cation uptake system
BINDI_RS00900	COG1321	iron dependent repressor
BINDI_RS00935	COG1088	dTDP-glucose 4,6-dehydratase activity
BINDI_RS00960	COG0438	transferase activity, transferring glycosyl groups
BINDI_RS00960	COG1216	Glycosyl transferase, family 2
BINDI_RS00965	COG1216	Glycosyl transferase, family 2
BINDI_RS00965	COG0438	transferase activity, transferring glycosyl groups
BINDI_RS00970	COG1216	Glycosyl transferase, family 2
BINDI_RS00970	COG1442	glycosyl transferase family 8
BINDI_RS01020	COG3152	Membrane
BINDI_RS01025	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BINDI_RS01035	COG1328	CTP reductase activity
BINDI_RS01035	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BINDI_RS01040	COG0602	queuosine metabolic process
BINDI_RS01060	COG1252	NADH dehydrogenase
BINDI_RS01065	COG1271	oxidase subunit
BINDI_RS01070	COG1294	oxidase, subunit
BINDI_RS01075	COG4988	ABC transporter
BINDI_RS01080	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BINDI_RS01095	COG1414	Transcriptional regulator
BINDI_RS01130	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BINDI_RS01180	COG0742	ribosomal rna small subunit methyltransferase
BINDI_RS01210	COG1837	Belongs to the UPF0109 family
BINDI_RS01245	COG0519	Catalyzes the synthesis of GMP from XMP
BINDI_RS01250	COG0488	(ABC) transporter
BINDI_RS01255	COG0440	acetolactate synthase activity
BINDI_RS01295	COG0667	Aldo Keto reductase
BINDI_RS01360	COG0681	Belongs to the peptidase S26 family
BINDI_RS01365	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BINDI_RS01370	COG1609	Transcriptional regulator
BINDI_RS01415	COG2814	Major facilitator Superfamily
BINDI_RS01450	COG2252	PERMEase
BINDI_RS01475	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BINDI_RS01525	COG0095	Lipoate-protein ligase
BINDI_RS01530	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BINDI_RS01535	COG4499	WXG100 protein secretion system (Wss), protein YukC
BINDI_RS01535	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BINDI_RS01545	COG1216	Glycosyl transferase, family 2
BINDI_RS01550	COG1349	DNA-binding transcription factor activity
BINDI_RS01560	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
BINDI_RS01575	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BINDI_RS01580	COG1194	a g-specific adenine glycosylase
BINDI_RS01610	COG0714	Associated with various cellular activities
BINDI_RS01630	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
BINDI_RS01660	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BINDI_RS01665	COG0395	ABC-type sugar transport system, permease component
BINDI_RS01670	COG1175	transmembrane transport
BINDI_RS01700	COG2135	peptidase activity
BINDI_RS01730	COG3940	Belongs to the glycosyl hydrolase 43 family
BINDI_RS01735	COG2211	Major facilitator Superfamily
BINDI_RS01790	COG1722	exodeoxyribonuclease VII activity
BINDI_RS01795	COG1570	exodeoxyribonuclease VII activity
BINDI_RS01800	COG1924	4 iron, 4 sulfur cluster binding
BINDI_RS01805	COG0110	maltose O-acetyltransferase activity
BINDI_RS01815	COG2211	Major facilitator Superfamily
BINDI_RS01825	COG1874	Beta-galactosidase
BINDI_RS01830	COG1472	Belongs to the glycosyl hydrolase 3 family
BINDI_RS01850	COG3069	C4-dicarboxylate transmembrane transporter activity
BINDI_RS01855	COG1609	Transcriptional regulator
BINDI_RS01865	COG0667	Aldo Keto reductase
BINDI_RS01880	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BINDI_RS01915	COG3480	Lon protease (S16) C-terminal proteolytic domain
BINDI_RS01925	COG0477	Major facilitator Superfamily
BINDI_RS01995	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BINDI_RS02025	COG0587	DNA-directed DNA polymerase activity
BINDI_RS02070	COG1643	Atp-dependent helicase
BINDI_RS02075	COG2813	Specifically methylates the guanine in position
BINDI_RS02080	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BINDI_RS02130	COG0768	penicillin binding
BINDI_RS02135	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BINDI_RS02140	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BINDI_RS02155	COG0772	Belongs to the SEDS family
BINDI_RS02200	COG1070	Carbohydrate kinase
BINDI_RS02205	COG1940	carbohydrate kinase activity
BINDI_RS02215	COG0006	proline dipeptidase activity
BINDI_RS02220	COG0285	dihydrofolate synthase activity
BINDI_RS02230	COG1794	racemase activity, acting on amino acids and derivatives
BINDI_RS02250	COG1595	DNA-templated transcription, initiation
BINDI_RS02260	COG2017	converts alpha-aldose to the beta-anomer
BINDI_RS02280	COG1393	Belongs to the ArsC family
BINDI_RS02290	COG1687	branched-chain amino acid
BINDI_RS02295	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
BINDI_RS02300	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BINDI_RS02300	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BINDI_RS02305	COG0367	asparagine synthase
BINDI_RS02310	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BINDI_RS02325	COG1131	(ABC) transporter
BINDI_RS02345	COG2205	protein histidine kinase activity
BINDI_RS02360	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
BINDI_RS02365	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BINDI_RS02370	COG1217	gtp-binding protein TYPA
BINDI_RS02385	COG0287	Prephenate dehydrogenase
BINDI_RS02405	COG4166	transmembrane transport
BINDI_RS02410	COG0601	transmembrane transport
BINDI_RS02415	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BINDI_RS02455	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
BINDI_RS02465	COG0670	Belongs to the BI1 family
BINDI_RS02475	COG0656	L-ascorbic acid biosynthetic process
BINDI_RS02480	COG2357	RelA SpoT domain protein
BINDI_RS02495	COG0789	Transcriptional regulator
BINDI_RS02500	COG1063	alcohol dehydrogenase
BINDI_RS02515	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BINDI_RS02520	COG1546	Belongs to the CinA family
BINDI_RS02520	COG1058	Belongs to the CinA family
BINDI_RS02525	COG1396	sequence-specific DNA binding
BINDI_RS02545	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
BINDI_RS02555	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BINDI_RS02575	COG0142	geranyltranstransferase activity
BINDI_RS02585	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BINDI_RS02590	COG0187	DNA topoisomerase II activity
BINDI_RS02595	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BINDI_RS02620	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BINDI_RS02625	COG1196	nuclear chromosome segregation
BINDI_RS02640	COG1126	abc transporter atp-binding protein
BINDI_RS02645	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BINDI_RS02650	COG0765	amino acid transport
BINDI_RS02655	COG0765	amino acid transport
BINDI_RS02665	COG1126	abc transporter atp-binding protein
BINDI_RS02670	COG0765	amino acid transport
BINDI_RS02700	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BINDI_RS02730	COG1882	Formate acetyltransferase
BINDI_RS02735	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
BINDI_RS02775	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BINDI_RS02800	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BINDI_RS02825	COG0799	negative regulation of ribosome biogenesis
BINDI_RS02830	COG0406	alpha-ribazole phosphatase activity
BINDI_RS02840	COG0371	Dehydrogenase
BINDI_RS02865	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BINDI_RS02890	COG0802	atpase or kinase
BINDI_RS02930	COG0516	GMP reductase activity
BINDI_RS02990	COG0133	tryptophan synthase activity
BINDI_RS03005	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BINDI_RS03020	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BINDI_RS03040	COG1716	ATPase activity
BINDI_RS03120	COG1131	(ABC) transporter
BINDI_RS03145	COG2197	response regulator
BINDI_RS03200	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BINDI_RS03210	COG1012	belongs to the aldehyde dehydrogenase family
BINDI_RS03230	COG0045	succinate-CoA ligase (ADP-forming) activity
BINDI_RS03265	COG0438	transferase activity, transferring glycosyl groups
BINDI_RS03275	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BINDI_RS03315	COG0477	Major facilitator Superfamily
BINDI_RS03345	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BINDI_RS03350	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BINDI_RS03375	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BINDI_RS03390	COG0519	Catalyzes the synthesis of GMP from XMP
BINDI_RS03400	COG0488	(ABC) transporter
BINDI_RS03405	COG1285	pathogenesis
BINDI_RS03415	COG0588	phosphoglycerate mutase activity
BINDI_RS03420	COG0583	DNA-binding transcription factor activity
BINDI_RS03435	COG0167	dihydroorotate dehydrogenase activity
BINDI_RS03440	COG0543	2 iron, 2 sulfur cluster binding
BINDI_RS03445	COG0284	orotidine-5'-phosphate decarboxylase activity
BINDI_RS03450	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BINDI_RS03475	COG4214	carbohydrate transport
BINDI_RS03480	COG1129	ABC transporter
BINDI_RS03485	COG4213	ABC transporter substrate-binding protein
BINDI_RS03495	COG1129	ABC transporter
BINDI_RS03505	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BINDI_RS03515	COG2062	phosphohistidine phosphatase, SixA
BINDI_RS03535	COG1119	ATPase activity
BINDI_RS03550	COG0067	glutamate synthase
BINDI_RS03550	COG0069	glutamate synthase activity
BINDI_RS03550	COG0070	glutamate synthase
BINDI_RS03570	COG2860	membrane
BINDI_RS03575	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BINDI_RS03610	COG0537	adenosine 5'-monophosphoramidase activity
BINDI_RS03615	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BINDI_RS03630	COG2233	PERMEase
BINDI_RS03635	COG2151	metal-sulfur cluster biosynthetic enzyme
BINDI_RS03640	COG0822	iron-sulfur transferase activity
BINDI_RS03650	COG0396	ATPase activity
BINDI_RS03655	COG0719	Fe-S assembly protein
BINDI_RS03670	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BINDI_RS03675	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BINDI_RS03765	COG0280	phosphate acetyltransferase
BINDI_RS03765	COG0857	belongs to the CobB CobQ family
BINDI_RS03770	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BINDI_RS03775	COG0483	inositol monophosphate 1-phosphatase activity
BINDI_RS03795	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BINDI_RS03815	COG0494	nUDIX hydrolase
BINDI_RS03820	COG0469	pyruvate kinase activity
BINDI_RS03835	COG0237	dephospho-CoA kinase activity
BINDI_RS03840	COG0539	negative regulation of cytoplasmic translation
BINDI_RS03850	COG1121	(ABC) transporter
BINDI_RS03865	COG1329	Transcriptional regulator
BINDI_RS03870	COG0745	RESPONSE REGULATOR receiver
BINDI_RS03875	COG2205	protein histidine kinase activity
BINDI_RS03885	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BINDI_RS03920	COG1316	TRANSCRIPTIONal
BINDI_RS03930	COG1316	TRANSCRIPTIONal
BINDI_RS03955	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BINDI_RS04015	COG2249	NAD(P)H dehydrogenase (quinone) activity
BINDI_RS04025	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
BINDI_RS04040	COG0012	GTP binding
BINDI_RS04045	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BINDI_RS04060	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BINDI_RS04065	COG2873	o-acetylhomoserine
BINDI_RS04095	COG1053	succinate dehydrogenase
BINDI_RS04100	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BINDI_RS04105	COG4122	O-methyltransferase activity
BINDI_RS04110	COG1611	Belongs to the LOG family
BINDI_RS04125	COG1132	(ABC) transporter
BINDI_RS04145	COG1397	ADP-ribosylglycohydrolase
BINDI_RS04170	COG0842	Transport permease protein
BINDI_RS04210	COG1501	Belongs to the glycosyl hydrolase 31 family
BINDI_RS04215	COG0395	ABC-type sugar transport system, permease component
BINDI_RS04220	COG1175	transmembrane transport
BINDI_RS04230	COG1609	Transcriptional regulator
BINDI_RS04245	COG0647	UMP catabolic process
BINDI_RS04320	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BINDI_RS04330	COG1122	ATPase activity
BINDI_RS04335	COG4721	ABC-type cobalt transport system, permease component
BINDI_RS04340	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BINDI_RS04370	COG0489	protein tyrosine kinase activity
BINDI_RS04370	COG2151	metal-sulfur cluster biosynthetic enzyme
BINDI_RS04405	COG1940	carbohydrate kinase activity
BINDI_RS04445	COG1278	Cold shock
BINDI_RS04450	COG2205	protein histidine kinase activity
BINDI_RS04490	COG0714	Associated with various cellular activities
BINDI_RS04530	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BINDI_RS04555	COG0483	inositol monophosphate 1-phosphatase activity
BINDI_RS04560	COG4122	O-methyltransferase activity
BINDI_RS04565	COG1222	aaa ATPase
BINDI_RS04580	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BINDI_RS04795	COG1464	Belongs to the NlpA lipoprotein family
BINDI_RS04805	COG2011	ABC-type metal ion transport system permease component
BINDI_RS04825	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BINDI_RS04845	COG1368	sulfuric ester hydrolase activity
BINDI_RS04860	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
BINDI_RS04865	COG0735	belongs to the Fur family
BINDI_RS04870	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BINDI_RS04875	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BINDI_RS04880	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BINDI_RS04905	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BINDI_RS04910	COG0358	DNA primase activity
BINDI_RS04920	COG1764	response to oxidative stress
BINDI_RS04925	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BINDI_RS04940	COG0514	ATP-dependent DNA helicase (RecQ)
BINDI_RS04945	COG4608	Belongs to the ABC transporter superfamily
BINDI_RS04955	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BINDI_RS04965	COG0747	negative chemotaxis
BINDI_RS04980	COG0564	pseudouridine synthase activity
BINDI_RS04985	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BINDI_RS04995	COG0765	amino acid transport
BINDI_RS05010	COG1388	LysM domain
BINDI_RS05010	COG3942	CHAP domain
BINDI_RS05015	COG2177	Part of the ABC transporter FtsEX involved in
BINDI_RS05020	COG2884	Cell division ATP-binding protein ftsE
BINDI_RS05025	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BINDI_RS05030	COG2171	N-acyltransferase activity
BINDI_RS05040	COG0024	Methionine aminopeptidase
BINDI_RS05050	COG3590	peptidase
BINDI_RS05060	COG0708	Exodeoxyribonuclease III
BINDI_RS05070	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BINDI_RS05085	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BINDI_RS05115	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
BINDI_RS05125	COG4166	transmembrane transport
BINDI_RS05140	COG1946	Acyl-CoA thioesterase
BINDI_RS05155	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BINDI_RS05160	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
BINDI_RS05170	COG2027	D-alanyl-D-alanine carboxypeptidase
BINDI_RS05175	COG1215	transferase activity, transferring glycosyl groups
BINDI_RS05185	COG1215	transferase activity, transferring glycosyl groups
BINDI_RS05205	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BINDI_RS05245	COG0791	NLP P60 protein
BINDI_RS05250	COG1388	LysM domain
BINDI_RS05250	COG3942	CHAP domain
BINDI_RS05265	COG5002	protein histidine kinase activity
BINDI_RS05280	COG1175	transmembrane transport
BINDI_RS05290	COG1609	Transcriptional regulator
BINDI_RS05305	COG1575	Belongs to the MenA family. Type 1 subfamily
BINDI_RS05310	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BINDI_RS05380	COG1760	l-serine dehydratase
BINDI_RS05385	COG1760	l-serine dehydratase
BINDI_RS05390	COG1803	Methylglyoxal synthase
BINDI_RS05390	COG1597	lipid kinase activity
BINDI_RS05400	COG0328	RNA-DNA hybrid ribonuclease activity
BINDI_RS05420	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
BINDI_RS05425	COG0402	S-adenosylhomocysteine deaminase activity
BINDI_RS05435	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BINDI_RS05440	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BINDI_RS05450	COG1126	abc transporter atp-binding protein
BINDI_RS05520	COG0071	Belongs to the small heat shock protein (HSP20) family
BINDI_RS05525	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BINDI_RS05530	COG1132	(ABC) transporter
BINDI_RS05535	COG1132	(ABC) transporter
BINDI_RS05605	COG0255	Belongs to the universal ribosomal protein uL29 family
BINDI_RS05655	COG1454	alcohol dehydrogenase
BINDI_RS05655	COG1012	belongs to the aldehyde dehydrogenase family
BINDI_RS05675	COG1739	Uncharacterized protein family UPF0029
BINDI_RS05685	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BINDI_RS05695	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
BINDI_RS05700	COG0531	amino acid
BINDI_RS05705	COG1904	glucuronate isomerase
BINDI_RS05710	COG1609	Transcriptional regulator
BINDI_RS05715	COG0246	Mannitol dehydrogenase
BINDI_RS05720	COG1312	Catalyzes the dehydration of D-mannonate
BINDI_RS05725	COG0800	Aldolase
BINDI_RS05730	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BINDI_RS05735	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BINDI_RS05740	COG2873	o-acetylhomoserine
BINDI_RS05760	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BINDI_RS05765	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BINDI_RS05775	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BINDI_RS05780	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BINDI_RS05800	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BINDI_RS05815	COG1970	mechanosensitive ion channel activity
BINDI_RS05855	COG3408	Glycogen debranching enzyme
BINDI_RS05855	COG3119	arylsulfatase activity
BINDI_RS05865	COG0395	ABC-type sugar transport system, permease component
BINDI_RS05885	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BINDI_RS05890	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BINDI_RS05895	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BINDI_RS05900	COG3579	cysteine-type endopeptidase activity
BINDI_RS05915	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
BINDI_RS05990	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BINDI_RS06000	COG0436	Aminotransferase
BINDI_RS06025	COG1530	ribonuclease E activity
BINDI_RS06030	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BINDI_RS06045	COG0083	homoserine kinase activity
BINDI_RS06050	COG0460	homoserine dehydrogenase
BINDI_RS06070	COG0251	oxidation-reduction process
BINDI_RS06115	COG4886	Leucine-rich repeat (LRR) protein
BINDI_RS06135	COG0545	Peptidyl-prolyl cis-trans isomerase
BINDI_RS06150	COG0765	amino acid transport
BINDI_RS06205	COG0356	it plays a direct role in the translocation of protons across the membrane
BINDI_RS06225	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BINDI_RS06250	COG0745	RESPONSE REGULATOR receiver
BINDI_RS06260	COG0747	negative chemotaxis
BINDI_RS06320	COG1131	(ABC) transporter
BINDI_RS06335	COG1322	Protein conserved in bacteria
BINDI_RS06340	COG2217	Heavy metal translocating P-type atpase
BINDI_RS06365	COG1228	amidohydrolase
BINDI_RS06400	COG1754	DNA topoisomerase type I activity
BINDI_RS06400	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BINDI_RS06415	COG1260	myo-inositol-1-phosphate synthase
BINDI_RS06420	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BINDI_RS06435	COG2271	Major facilitator Superfamily
BINDI_RS06455	COG2390	Transcriptional regulator
BINDI_RS06465	COG0527	aspartate kinase activity
BINDI_RS06520	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BINDI_RS06525	COG0406	alpha-ribazole phosphatase activity
BINDI_RS06525	COG0494	nUDIX hydrolase
BINDI_RS06540	COG0584	glycerophosphoryl diester phosphodiesterase
BINDI_RS06550	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BINDI_RS06555	COG0305	Participates in initiation and elongation during chromosome replication
BINDI_RS06560	COG0534	Mate efflux family protein
BINDI_RS06620	COG2184	nucleotidyltransferase activity
BINDI_RS06645	COG0640	Transcriptional regulator
BINDI_RS06650	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BINDI_RS06660	COG0577	efflux transmembrane transporter activity
BINDI_RS06660	COG1136	(ABC) transporter
BINDI_RS06675	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BINDI_RS06700	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BINDI_RS06705	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BINDI_RS06710	COG1120	ATPase activity
BINDI_RS06720	COG0512	Glutamine amidotransferase of anthranilate synthase
BINDI_RS06735	COG1063	alcohol dehydrogenase
BINDI_RS06750	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BINDI_RS06755	COG0542	response to heat
BINDI_RS06765	COG0477	Major facilitator Superfamily
BINDI_RS06775	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BINDI_RS06785	COG0577	efflux transmembrane transporter activity
BINDI_RS06785	COG1136	(ABC) transporter
BINDI_RS06805	COG3470	protein probably involved in high-affinity Fe2 transport
BINDI_RS06810	COG0672	)-iron permease
BINDI_RS06815	COG1113	amino acid transport
BINDI_RS06820	COG1113	amino acid transport
BINDI_RS06825	COG0833	amino acid
BINDI_RS06830	COG0833	amino acid
BINDI_RS06840	COG1477	protein flavinylation
BINDI_RS06870	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BINDI_RS06880	COG3842	ATPase activity
BINDI_RS06905	COG3583	domain protein
BINDI_RS06925	COG0617	tRNA 3'-terminal CCA addition
BINDI_RS06945	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BINDI_RS06950	COG1181	Belongs to the D-alanine--D-alanine ligase family
BINDI_RS06960	COG0492	ferredoxin-NADP+ reductase activity
BINDI_RS06975	COG1192	Involved in chromosome partitioning
BINDI_RS06985	COG1847	R3H domain protein
BINDI_RS07025	COG1132	(ABC) transporter
BINDI_RS07030	COG1132	(ABC) transporter
BINDI_RS07040	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
BINDI_RS07135	COG4585	Histidine kinase
BINDI_RS07140	COG2964	Protein conserved in bacteria