locus-tag	class	description
BL8807_RS00040	COG0287	Prephenate dehydrogenase
BL8807_RS00055	COG1217	gtp-binding protein TYPA
BL8807_RS00060	COG0477	Major facilitator Superfamily
BL8807_RS00070	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BL8807_RS00100	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BL8807_RS00135	COG1595	DNA-templated transcription, initiation
BL8807_RS00150	COG1196	nuclear chromosome segregation
BL8807_RS00155	COG0285	dihydrofolate synthase activity
BL8807_RS00160	COG0006	proline dipeptidase activity
BL8807_RS00180	COG0395	ABC-type sugar transport system, permease component
BL8807_RS00185	COG1175	transmembrane transport
BL8807_RS00190	COG2182	Extracellular solute-binding protein
BL8807_RS00215	COG1940	carbohydrate kinase activity
BL8807_RS00220	COG1940	carbohydrate kinase activity
BL8807_RS00225	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
BL8807_RS00225	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
BL8807_RS00275	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BL8807_RS00285	COG0768	penicillin binding
BL8807_RS00310	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BL8807_RS00330	COG1230	cation diffusion facilitator family transporter
BL8807_RS00340	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BL8807_RS00345	COG2813	Specifically methylates the guanine in position
BL8807_RS00350	COG1643	Atp-dependent helicase
BL8807_RS00365	COG0732	type I restriction modification DNA specificity domain
BL8807_RS00380	COG2826	transposase and inactivated derivatives, IS30 family
BL8807_RS00405	COG2814	Major facilitator Superfamily
BL8807_RS00410	COG0174	glutamine synthetase
BL8807_RS00480	COG0577	efflux transmembrane transporter activity
BL8807_RS00485	COG1136	(ABC) transporter
BL8807_RS00495	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BL8807_RS00500	COG0587	DNA-directed DNA polymerase activity
BL8807_RS00530	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BL8807_RS00545	COG3579	cysteine-type endopeptidase activity
BL8807_RS00560	COG0351	phosphomethylpyrimidine kinase
BL8807_RS00635	COG3480	Lon protease (S16) C-terminal proteolytic domain
BL8807_RS00660	COG0613	PHP domain protein
BL8807_RS00670	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BL8807_RS00690	COG0436	Aminotransferase
BL8807_RS00695	COG2011	ABC-type metal ion transport system permease component
BL8807_RS00700	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BL8807_RS00705	COG1464	Belongs to the NlpA lipoprotein family
BL8807_RS00710	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BL8807_RS00715	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BL8807_RS00720	COG1126	abc transporter atp-binding protein
BL8807_RS00725	COG0765	amino acid transport
BL8807_RS00730	COG0765	amino acid transport
BL8807_RS00755	COG2801	Transposase and inactivated derivatives
BL8807_RS00770	COG0745	RESPONSE REGULATOR receiver
BL8807_RS00770	COG3292	Two component regulator propeller
BL8807_RS00770	COG2205	protein histidine kinase activity
BL8807_RS00775	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BL8807_RS00825	COG3250	beta-galactosidase activity
BL8807_RS00830	COG1609	Transcriptional regulator
BL8807_RS00840	COG1132	(ABC) transporter
BL8807_RS00845	COG1132	(ABC) transporter
BL8807_RS00850	COG0039	L-malate dehydrogenase activity
BL8807_RS00870	COG2211	Major facilitator Superfamily
BL8807_RS00875	COG3250	beta-galactosidase activity
BL8807_RS00885	COG1609	Transcriptional regulator
BL8807_RS00890	COG0673	inositol 2-dehydrogenase activity
BL8807_RS00900	COG1028	Short-chain dehydrogenase reductase Sdr
BL8807_RS00915	COG3226	Transcriptional regulator
BL8807_RS00935	COG1373	ATPase (AAA superfamily
BL8807_RS00940	COG3507	Belongs to the glycosyl hydrolase 43 family
BL8807_RS00960	COG1472	Belongs to the glycosyl hydrolase 3 family
BL8807_RS00985	COG2211	Major facilitator Superfamily
BL8807_RS00990	COG3226	Transcriptional regulator
BL8807_RS01030	COG0676	glucose-6-phosphate 1-epimerase activity
BL8807_RS01035	COG0602	queuosine metabolic process
BL8807_RS01040	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BL8807_RS01040	COG1328	CTP reductase activity
BL8807_RS01045	COG1570	exodeoxyribonuclease VII activity
BL8807_RS01050	COG1722	exodeoxyribonuclease VII activity
BL8807_RS01055	COG1028	Short-chain dehydrogenase reductase Sdr
BL8807_RS01060	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
BL8807_RS01075	COG1131	(ABC) transporter
BL8807_RS01095	COG0436	Aminotransferase
BL8807_RS01110	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BL8807_RS01130	COG3958	Transketolase
BL8807_RS01135	COG3959	Transketolase, thiamine diphosphate binding domain
BL8807_RS01140	COG1172	Belongs to the binding-protein-dependent transport system permease family
BL8807_RS01145	COG1129	ABC transporter
BL8807_RS01150	COG1879	ABC-type sugar transport system periplasmic component
BL8807_RS01165	COG0024	Methionine aminopeptidase
BL8807_RS01175	COG3590	peptidase
BL8807_RS01195	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BL8807_RS01210	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BL8807_RS01370	COG1070	Carbohydrate kinase
BL8807_RS01385	COG1522	sequence-specific DNA binding
BL8807_RS01390	COG1174	glycine betaine transport
BL8807_RS01395	COG1125	glycine betaine transport
BL8807_RS01395	COG0517	IMP dehydrogenase activity
BL8807_RS01400	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BL8807_RS01415	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BL8807_RS01420	COG4214	carbohydrate transport
BL8807_RS01430	COG4213	ABC transporter substrate-binding protein
BL8807_RS01455	COG0395	ABC-type sugar transport system, permease component
BL8807_RS01460	COG1175	transmembrane transport
BL8807_RS01470	COG1609	Transcriptional regulator
BL8807_RS01510	COG3507	Belongs to the glycosyl hydrolase 43 family
BL8807_RS01515	COG0395	ABC-type sugar transport system, permease component
BL8807_RS01520	COG1175	transmembrane transport
BL8807_RS01530	COG1609	Transcriptional regulator
BL8807_RS01540	COG3507	Belongs to the glycosyl hydrolase 43 family
BL8807_RS01565	COG1946	Acyl-CoA thioesterase
BL8807_RS01585	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BL8807_RS01590	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
BL8807_RS01630	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BL8807_RS01670	COG0714	Associated with various cellular activities
BL8807_RS01700	COG1194	a g-specific adenine glycosylase
BL8807_RS01705	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BL8807_RS01720	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BL8807_RS01745	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
BL8807_RS01755	COG1349	DNA-binding transcription factor activity
BL8807_RS01760	COG0167	dihydroorotate dehydrogenase activity
BL8807_RS01765	COG1902	pentaerythritol trinitrate reductase activity
BL8807_RS01770	COG4499	WXG100 protein secretion system (Wss), protein YukC
BL8807_RS01770	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BL8807_RS01775	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BL8807_RS01870	COG1088	dTDP-glucose 4,6-dehydratase activity
BL8807_RS01875	COG2723	6-phospho-beta-galactosidase activity
BL8807_RS01880	COG0395	ABC-type sugar transport system, permease component
BL8807_RS01885	COG1175	transmembrane transport
BL8807_RS01895	COG1609	Transcriptional regulator
BL8807_RS01935	COG1215	transferase activity, transferring glycosyl groups
BL8807_RS01965	COG1484	DNA-dependent DNA replication
BL8807_RS02000	COG1216	Glycosyl transferase, family 2
BL8807_RS02005	COG0438	transferase activity, transferring glycosyl groups
BL8807_RS02010	COG0110	maltose O-acetyltransferase activity
BL8807_RS02020	COG0438	transferase activity, transferring glycosyl groups
BL8807_RS02030	COG0438	transferase activity, transferring glycosyl groups
BL8807_RS02035	COG0489	protein tyrosine kinase activity
BL8807_RS02045	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BL8807_RS02070	COG2814	Major facilitator Superfamily
BL8807_RS02080	COG3549	Plasmid maintenance system killer
BL8807_RS02095	COG0656	L-ascorbic acid biosynthetic process
BL8807_RS02100	COG2814	Major facilitator Superfamily
BL8807_RS02105	COG3867	Arabinogalactan endo-beta-1,4-galactanase
BL8807_RS02110	COG1609	Transcriptional regulator
BL8807_RS02120	COG0395	ABC-type sugar transport system, permease component
BL8807_RS02125	COG1175	transmembrane transport
BL8807_RS02130	COG1653	transport
BL8807_RS02135	COG1132	(ABC) transporter
BL8807_RS02155	COG0477	Major facilitator Superfamily
BL8807_RS02160	COG0477	Major facilitator Superfamily
BL8807_RS02165	COG1609	Transcriptional regulator
BL8807_RS02175	COG2814	Major facilitator Superfamily
BL8807_RS02195	COG1609	Transcriptional regulator
BL8807_RS02200	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BL8807_RS02205	COG0681	Belongs to the peptidase S26 family
BL8807_RS02350	COG1609	Transcriptional regulator
BL8807_RS02355	COG1132	(ABC) transporter
BL8807_RS02360	COG1132	(ABC) transporter
BL8807_RS02365	COG0488	(ABC) transporter
BL8807_RS02385	COG3279	Response regulator of the LytR AlgR family
BL8807_RS02400	COG1472	Belongs to the glycosyl hydrolase 3 family
BL8807_RS02430	COG1196	nuclear chromosome segregation
BL8807_RS02445	COG1837	Belongs to the UPF0109 family
BL8807_RS02465	COG0395	ABC-type sugar transport system, permease component
BL8807_RS02470	COG4209	transmembrane transport
BL8807_RS02500	COG1704	LemA family
BL8807_RS02520	COG3177	Filamentation induced by cAMP protein fic
BL8807_RS02555	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BL8807_RS02560	COG4770	biotin carboxylase activity
BL8807_RS02565	COG1268	BioY protein
BL8807_RS02600	COG3279	Response regulator of the LytR AlgR family
BL8807_RS02620	COG0154	amidase activity
BL8807_RS02630	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BL8807_RS02645	COG2186	Transcriptional regulator
BL8807_RS02655	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BL8807_RS02665	COG0436	Aminotransferase
BL8807_RS02670	COG0726	polysaccharide deacetylase
BL8807_RS02725	COG2801	Transposase and inactivated derivatives
BL8807_RS02745	COG1530	ribonuclease E activity
BL8807_RS02750	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BL8807_RS02780	COG0083	homoserine kinase activity
BL8807_RS02785	COG0460	homoserine dehydrogenase
BL8807_RS02790	COG2190	(PTS) system
BL8807_RS02790	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BL8807_RS02790	COG1263	PTS System
BL8807_RS02795	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BL8807_RS02795	COG2190	(PTS) system
BL8807_RS02795	COG1263	PTS System
BL8807_RS02810	COG1309	transcriptional regulator
BL8807_RS02820	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BL8807_RS02845	COG3428	Bacterial PH domain
BL8807_RS02890	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BL8807_RS02895	COG3152	Membrane
BL8807_RS02950	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BL8807_RS02955	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BL8807_RS02960	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BL8807_RS02970	COG1754	DNA topoisomerase type I activity
BL8807_RS02970	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BL8807_RS03010	COG0395	ABC-type sugar transport system, permease component
BL8807_RS03015	COG4209	transmembrane transport
BL8807_RS03020	COG1653	transport
BL8807_RS03025	COG3940	Belongs to the glycosyl hydrolase 43 family
BL8807_RS03030	COG1609	Transcriptional regulator
BL8807_RS03040	COG3507	Belongs to the glycosyl hydrolase 43 family
BL8807_RS03045	COG3507	Belongs to the glycosyl hydrolase 43 family
BL8807_RS03065	COG2186	Transcriptional regulator
BL8807_RS03095	COG1309	transcriptional regulator
BL8807_RS03165	COG3279	Response regulator of the LytR AlgR family
BL8807_RS03190	COG1309	transcriptional regulator
BL8807_RS03200	COG1874	Beta-galactosidase
BL8807_RS03205	COG3507	Belongs to the glycosyl hydrolase 43 family
BL8807_RS03210	COG1501	Belongs to the glycosyl hydrolase 31 family
BL8807_RS03215	COG1472	Belongs to the glycosyl hydrolase 3 family
BL8807_RS03230	COG0395	ABC-type sugar transport system, permease component
BL8807_RS03235	COG4209	transmembrane transport
BL8807_RS03245	COG1501	Belongs to the glycosyl hydrolase 31 family
BL8807_RS03255	COG1175	transmembrane transport
BL8807_RS03265	COG1609	Transcriptional regulator
BL8807_RS03270	COG3311	Transcriptional regulator
BL8807_RS03290	COG0494	nUDIX hydrolase
BL8807_RS03300	COG1368	sulfuric ester hydrolase activity
BL8807_RS03315	COG1216	Glycosyl transferase, family 2
BL8807_RS03330	COG3475	LICD family
BL8807_RS03365	COG0463	Glycosyl transferase, family 2
BL8807_RS03375	COG1569	PIN domain
BL8807_RS03380	COG3311	Transcriptional regulator
BL8807_RS03395	COG0300	oxidoreductase activity
BL8807_RS03440	COG1501	Belongs to the glycosyl hydrolase 31 family
BL8807_RS03445	COG0395	ABC-type sugar transport system, permease component
BL8807_RS03450	COG1175	transmembrane transport
BL8807_RS03465	COG3534	alpha-L-arabinofuranosidase
BL8807_RS03480	COG0789	Transcriptional regulator
BL8807_RS03485	COG0484	heat shock protein binding
BL8807_RS03505	COG1501	Belongs to the glycosyl hydrolase 31 family
BL8807_RS03510	COG1609	Transcriptional regulator
BL8807_RS03520	COG0366	Alpha amylase catalytic
BL8807_RS03530	COG1175	transmembrane transport
BL8807_RS03535	COG3833	ABC-type maltose transport systems, permease component
BL8807_RS03540	COG1523	belongs to the glycosyl hydrolase 13 family
BL8807_RS03565	COG0366	Alpha amylase catalytic
BL8807_RS03580	COG1609	Transcriptional regulator
BL8807_RS03600	COG0778	Nitroreductase
BL8807_RS03645	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BL8807_RS03650	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BL8807_RS03655	COG0366	Alpha amylase catalytic
BL8807_RS03660	COG0366	Alpha amylase catalytic
BL8807_RS03665	COG0395	ABC-type sugar transport system, permease component
BL8807_RS03685	COG1609	Transcriptional regulator
BL8807_RS03700	COG1175	transmembrane transport
BL8807_RS03720	COG0590	tRNA wobble adenosine to inosine editing
BL8807_RS03720	COG0037	tRNA processing
BL8807_RS03725	COG0025	NhaP-type Na H and K H
BL8807_RS03730	COG0730	response to heat
BL8807_RS03745	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BL8807_RS03770	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BL8807_RS03800	COG3842	ATPase activity
BL8807_RS03810	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BL8807_RS03815	COG0765	amino acid transport
BL8807_RS03820	COG1126	abc transporter atp-binding protein
BL8807_RS03825	COG0436	Aminotransferase
BL8807_RS03840	COG1472	Belongs to the glycosyl hydrolase 3 family
BL8807_RS03845	COG3279	Response regulator of the LytR AlgR family
BL8807_RS03855	COG2826	transposase and inactivated derivatives, IS30 family
BL8807_RS03860	COG0789	Transcriptional regulator
BL8807_RS03885	COG1472	Belongs to the glycosyl hydrolase 3 family
BL8807_RS03895	COG0583	DNA-binding transcription factor activity
BL8807_RS03925	COG0745	RESPONSE REGULATOR receiver
BL8807_RS03965	COG3583	domain protein
BL8807_RS03985	COG0617	tRNA 3'-terminal CCA addition
BL8807_RS04005	COG1475	DNA binding
BL8807_RS04010	COG1192	Involved in chromosome partitioning
BL8807_RS04020	COG1847	R3H domain protein
BL8807_RS04050	COG0592	DNA-directed DNA polymerase activity
BL8807_RS04065	COG0187	DNA topoisomerase II activity
BL8807_RS04070	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BL8807_RS04115	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BL8807_RS04120	COG3279	Response regulator of the LytR AlgR family
BL8807_RS04130	COG1472	Belongs to the glycosyl hydrolase 3 family
BL8807_RS04140	COG3250	beta-galactosidase activity
BL8807_RS04165	COG0745	RESPONSE REGULATOR receiver
BL8807_RS04185	COG1472	Belongs to the glycosyl hydrolase 3 family
BL8807_RS04190	COG3279	Response regulator of the LytR AlgR family
BL8807_RS04210	COG1970	mechanosensitive ion channel activity
BL8807_RS04230	COG0783	Belongs to the Dps family
BL8807_RS04235	COG1253	flavin adenine dinucleotide binding
BL8807_RS04240	COG0288	reversible hydration of carbon dioxide
BL8807_RS04265	COG0110	maltose O-acetyltransferase activity
BL8807_RS04270	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
BL8807_RS04280	COG4565	transcriptional regulatory protein
BL8807_RS04305	COG0180	Tryptophanyl-tRNA synthetase
BL8807_RS04330	COG0058	SHG alpha-glucan phosphorylase activity
BL8807_RS04370	COG1940	carbohydrate kinase activity
BL8807_RS04400	COG0515	serine threonine protein kinase
BL8807_RS04405	COG0768	penicillin binding
BL8807_RS04435	COG1609	Transcriptional regulator
BL8807_RS04460	COG0697	spore germination
BL8807_RS04475	COG1397	ADP-ribosylglycohydrolase
BL8807_RS04510	COG0343	queuine tRNA-ribosyltransferase activity
BL8807_RS04515	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BL8807_RS04535	COG0667	Aldo Keto reductase
BL8807_RS04555	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
BL8807_RS04565	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
BL8807_RS04580	COG3279	Response regulator of the LytR AlgR family
BL8807_RS04600	COG0191	fructose-bisphosphate aldolase activity
BL8807_RS04635	COG0477	Major facilitator Superfamily
BL8807_RS04645	COG1609	Transcriptional regulator
BL8807_RS04650	COG0366	Alpha amylase catalytic
BL8807_RS04675	COG1113	amino acid transport
BL8807_RS04685	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BL8807_RS04685	COG2755	lipolytic protein G-D-S-L family
BL8807_RS04700	COG0601	transmembrane transport
BL8807_RS04705	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BL8807_RS04715	COG4608	Belongs to the ABC transporter superfamily
BL8807_RS04725	COG1609	Transcriptional regulator
BL8807_RS04750	COG1113	amino acid transport
BL8807_RS04765	COG1132	(ABC) transporter
BL8807_RS04775	COG2211	Major facilitator Superfamily
BL8807_RS04795	COG0494	nUDIX hydrolase
BL8807_RS04830	COG0084	hydrolase, TatD family'
BL8807_RS04850	COG1129	ABC transporter
BL8807_RS04860	COG0672	)-iron permease
BL8807_RS04875	COG0577	efflux transmembrane transporter activity
BL8807_RS04880	COG0577	efflux transmembrane transporter activity
BL8807_RS04910	COG0745	RESPONSE REGULATOR receiver
BL8807_RS05015	COG1192	Involved in chromosome partitioning
BL8807_RS05060	COG3942	CHAP domain
BL8807_RS05060	COG1705	Flagellar rod assembly protein muramidase FlgJ
BL8807_RS05080	COG3550	peptidyl-serine autophosphorylation
BL8807_RS05110	COG3843	relaxase mobilization nuclease domain protein
BL8807_RS05140	COG4974	Belongs to the 'phage' integrase family
BL8807_RS05150	COG0640	Transcriptional regulator
BL8807_RS05170	COG1215	transferase activity, transferring glycosyl groups
BL8807_RS05195	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
BL8807_RS05205	COG1175	transmembrane transport
BL8807_RS05250	COG0305	Participates in initiation and elongation during chromosome replication
BL8807_RS05255	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BL8807_RS05265	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BL8807_RS05270	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BL8807_RS05275	COG0668	transmembrane transport
BL8807_RS05310	COG1653	transport
BL8807_RS05315	COG1175	transmembrane transport
BL8807_RS05320	COG0395	ABC-type sugar transport system, permease component
BL8807_RS05330	COG1609	Transcriptional regulator
BL8807_RS05345	COG1122	ATPase activity
BL8807_RS05350	COG1122	ATPase activity
BL8807_RS05355	COG0135	phosphoribosylanthranilate isomerase activity
BL8807_RS05360	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BL8807_RS05370	COG0546	phosphoglycolate phosphatase activity
BL8807_RS05375	COG1979	alcohol dehydrogenase
BL8807_RS05410	COG0179	Fumarylacetoacetate (FAA) hydrolase
BL8807_RS05425	COG0584	glycerophosphoryl diester phosphodiesterase
BL8807_RS05460	COG0406	alpha-ribazole phosphatase activity
BL8807_RS05460	COG0494	nUDIX hydrolase
BL8807_RS05465	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BL8807_RS05520	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BL8807_RS05530	COG1609	Transcriptional regulator
BL8807_RS05535	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BL8807_RS05540	COG2217	Heavy metal translocating P-type atpase
BL8807_RS05550	COG1937	Protein conserved in bacteria
BL8807_RS05580	COG1131	(ABC) transporter
BL8807_RS05625	COG1396	sequence-specific DNA binding
BL8807_RS05630	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
BL8807_RS05640	COG2211	Major facilitator Superfamily
BL8807_RS05645	COG1609	Transcriptional regulator
BL8807_RS05650	COG0287	Prephenate dehydrogenase
BL8807_RS05650	COG1605	Chorismate mutase
BL8807_RS05690	COG0745	RESPONSE REGULATOR receiver
BL8807_RS05705	COG0789	Transcriptional regulator
BL8807_RS05715	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BL8807_RS05755	COG0356	it plays a direct role in the translocation of protons across the membrane
BL8807_RS05790	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BL8807_RS05840	COG0251	oxidation-reduction process
BL8807_RS05875	COG3842	ATPase activity
BL8807_RS05900	COG0477	Major facilitator Superfamily
BL8807_RS05905	COG0477	Major facilitator Superfamily
BL8807_RS05910	COG2270	Major facilitator Superfamily
BL8807_RS05930	COG0742	ribosomal rna small subunit methyltransferase
BL8807_RS05940	COG0826	peptidase U32
BL8807_RS05955	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
BL8807_RS05965	COG3579	cysteine-type endopeptidase activity
BL8807_RS05970	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BL8807_RS05975	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BL8807_RS05980	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BL8807_RS06000	COG5002	protein histidine kinase activity
BL8807_RS06005	COG0745	RESPONSE REGULATOR receiver
BL8807_RS06030	COG2252	PERMEase
BL8807_RS06040	COG1373	ATPase (AAA superfamily
BL8807_RS06060	COG1175	transmembrane transport
BL8807_RS06065	COG0395	ABC-type sugar transport system, permease component
BL8807_RS06115	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BL8807_RS06135	COG0714	Associated with various cellular activities
BL8807_RS06145	COG0626	cystathionine gamma-synthase activity
BL8807_RS06150	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BL8807_RS06175	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BL8807_RS06180	COG0531	amino acid
BL8807_RS06195	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BL8807_RS06220	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BL8807_RS06225	COG1739	Uncharacterized protein family UPF0029
BL8807_RS06280	COG1454	alcohol dehydrogenase
BL8807_RS06280	COG1012	belongs to the aldehyde dehydrogenase family
BL8807_RS06330	COG0255	Belongs to the universal ribosomal protein uL29 family
BL8807_RS06435	COG2308	Evidence 4 Homologs of previously reported genes of
BL8807_RS06475	COG0196	riboflavin kinase activity
BL8807_RS06480	COG1126	abc transporter atp-binding protein
BL8807_RS06485	COG0765	amino acid transport
BL8807_RS06495	COG0402	S-adenosylhomocysteine deaminase activity
BL8807_RS06500	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
BL8807_RS06525	COG0328	RNA-DNA hybrid ribonuclease activity
BL8807_RS06530	COG1609	Transcriptional regulator
BL8807_RS06535	COG0246	Mannitol dehydrogenase
BL8807_RS06540	COG1312	Catalyzes the dehydration of D-mannonate
BL8807_RS06550	COG0800	Aldolase
BL8807_RS06555	COG1904	glucuronate isomerase
BL8807_RS06565	COG1803	Methylglyoxal synthase
BL8807_RS06565	COG1597	lipid kinase activity
BL8807_RS06580	COG3711	transcriptional antiterminator
BL8807_RS06600	COG0531	amino acid
BL8807_RS06605	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
BL8807_RS06625	COG1175	transmembrane transport
BL8807_RS06630	COG0395	ABC-type sugar transport system, permease component
BL8807_RS06655	COG2197	response regulator
BL8807_RS06685	COG2814	Major facilitator Superfamily
BL8807_RS06695	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BL8807_RS06715	COG0704	Plays a role in the regulation of phosphate uptake
BL8807_RS06720	COG5002	protein histidine kinase activity
BL8807_RS06735	COG1388	LysM domain
BL8807_RS06735	COG3942	CHAP domain
BL8807_RS06750	COG0589	response to stress
BL8807_RS06770	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BL8807_RS06785	COG1175	transmembrane transport
BL8807_RS06790	COG0395	ABC-type sugar transport system, permease component
BL8807_RS06820	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BL8807_RS06835	COG1216	Glycosyl transferase, family 2
BL8807_RS06855	COG1454	alcohol dehydrogenase
BL8807_RS06875	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BL8807_RS06880	COG2884	Cell division ATP-binding protein ftsE
BL8807_RS06885	COG2177	Part of the ABC transporter FtsEX involved in
BL8807_RS06890	COG3942	CHAP domain
BL8807_RS06890	COG1388	LysM domain
BL8807_RS06900	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BL8807_RS06905	COG0564	pseudouridine synthase activity
BL8807_RS06910	COG1609	Transcriptional regulator
BL8807_RS06915	COG1175	transmembrane transport
BL8807_RS06920	COG0395	ABC-type sugar transport system, permease component
BL8807_RS06930	COG3534	alpha-L-arabinofuranosidase
BL8807_RS06935	COG1653	transport
BL8807_RS06945	COG1653	transport
BL8807_RS06965	COG0601	transmembrane transport
BL8807_RS06970	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BL8807_RS06980	COG4608	Belongs to the ABC transporter superfamily
BL8807_RS06990	COG1131	(ABC) transporter
BL8807_RS07015	COG1131	(ABC) transporter
BL8807_RS07020	COG1131	(ABC) transporter
BL8807_RS07030	COG1609	Transcriptional regulator
BL8807_RS07045	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BL8807_RS07050	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
BL8807_RS07055	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
BL8807_RS07060	COG0514	ATP-dependent DNA helicase (RecQ)
BL8807_RS07080	COG3265	gluconokinase activity
BL8807_RS07090	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
BL8807_RS07095	COG1609	Transcriptional regulator
BL8807_RS07100	COG1028	Short-chain dehydrogenase reductase Sdr
BL8807_RS07105	COG2610	gluconate transmembrane transporter activity
BL8807_RS07110	COG0531	amino acid
BL8807_RS07115	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BL8807_RS07145	COG0358	DNA primase activity
BL8807_RS07150	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BL8807_RS07150	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BL8807_RS07165	COG3842	ATPase activity
BL8807_RS07170	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BL8807_RS07180	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
BL8807_RS07190	COG3152	Membrane
BL8807_RS07205	COG0300	oxidoreductase activity
BL8807_RS07225	COG2910	NAD(P)H-binding
BL8807_RS07230	COG1733	regulation of RNA biosynthetic process
BL8807_RS07235	COG0577	efflux transmembrane transporter activity
BL8807_RS07235	COG1136	(ABC) transporter
BL8807_RS07245	COG0577	efflux transmembrane transporter activity
BL8807_RS07250	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BL8807_RS07260	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BL8807_RS07265	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BL8807_RS07290	COG1028	Short-chain dehydrogenase reductase Sdr
BL8807_RS07295	COG1012	belongs to the aldehyde dehydrogenase family
BL8807_RS07320	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BL8807_RS07340	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BL8807_RS07360	COG0363	glucosamine-6-phosphate deaminase activity
BL8807_RS07370	COG0577	efflux transmembrane transporter activity
BL8807_RS07370	COG1136	(ABC) transporter
BL8807_RS07375	COG4181	ATPase activity
BL8807_RS07390	COG2197	response regulator
BL8807_RS07395	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BL8807_RS07415	COG4716	Myosin-crossreactive antigen
BL8807_RS07460	COG1131	(ABC) transporter
BL8807_RS07495	COG0284	orotidine-5'-phosphate decarboxylase activity
BL8807_RS07505	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
BL8807_RS07525	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BL8807_RS07540	COG0560	Phosphoserine phosphatase
BL8807_RS07545	COG0586	Pfam SNARE associated Golgi protein
BL8807_RS07555	COG4122	O-methyltransferase activity
BL8807_RS07585	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BL8807_RS07590	COG0745	RESPONSE REGULATOR receiver
BL8807_RS07655	COG0714	Associated with various cellular activities
BL8807_RS07670	COG1278	Cold shock
BL8807_RS07690	COG0745	RESPONSE REGULATOR receiver
BL8807_RS07695	COG2205	protein histidine kinase activity
BL8807_RS07710	COG0589	response to stress
BL8807_RS07720	COG1196	nuclear chromosome segregation
BL8807_RS07740	COG1126	abc transporter atp-binding protein
BL8807_RS07745	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BL8807_RS07750	COG0765	amino acid transport
BL8807_RS07755	COG0765	amino acid transport
BL8807_RS07765	COG0366	Alpha amylase catalytic
BL8807_RS07780	COG2814	Major facilitator Superfamily
BL8807_RS07815	COG0436	Aminotransferase
BL8807_RS07820	COG1122	ATPase activity
BL8807_RS07850	COG0371	Dehydrogenase
BL8807_RS07860	COG0488	(ABC) transporter
BL8807_RS07865	COG1121	(ABC) transporter
BL8807_RS07890	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BL8807_RS07895	COG4721	ABC-type cobalt transport system, permease component
BL8807_RS07910	COG2197	response regulator
BL8807_RS07925	COG1136	(ABC) transporter
BL8807_RS07945	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BL8807_RS08065	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BL8807_RS08075	COG1131	(ABC) transporter
BL8807_RS08090	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
BL8807_RS08120	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BL8807_RS08135	COG1247	-acetyltransferase
BL8807_RS08155	COG2116	formate transmembrane transporter activity
BL8807_RS08160	COG0789	Transcriptional regulator
BL8807_RS08165	COG0667	Aldo Keto reductase
BL8807_RS08175	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BL8807_RS08235	COG0477	Major facilitator Superfamily
BL8807_RS08240	COG1116	anion transmembrane transporter activity
BL8807_RS08250	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BL8807_RS08260	COG1950	PFAM Membrane protein of
BL8807_RS08270	COG2814	Major facilitator Superfamily
BL8807_RS08300	COG3645	SOS response
BL8807_RS08315	COG1760	l-serine dehydratase
BL8807_RS08325	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BL8807_RS08350	COG1316	TRANSCRIPTIONal
BL8807_RS08390	COG2205	protein histidine kinase activity
BL8807_RS08395	COG0745	RESPONSE REGULATOR receiver
BL8807_RS08405	COG1329	Transcriptional regulator
BL8807_RS08420	COG1121	(ABC) transporter
BL8807_RS08435	COG0539	negative regulation of cytoplasmic translation
BL8807_RS08445	COG3842	ATPase activity
BL8807_RS08455	COG2197	response regulator
BL8807_RS08475	COG0469	pyruvate kinase activity
BL8807_RS08485	COG0582	viral genome integration into host DNA
BL8807_RS08525	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BL8807_RS08525	COG0551	DNA topoisomerase type I activity
BL8807_RS08535	COG3843	relaxase mobilization nuclease domain protein
BL8807_RS08585	COG3942	CHAP domain
BL8807_RS08585	COG1705	Flagellar rod assembly protein muramidase FlgJ
BL8807_RS08630	COG1192	Involved in chromosome partitioning
BL8807_RS08665	COG0494	nUDIX hydrolase
BL8807_RS08680	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BL8807_RS08685	COG1051	belongs to the nudix hydrolase family
BL8807_RS08715	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BL8807_RS08720	COG0280	phosphate acetyltransferase
BL8807_RS08720	COG0857	belongs to the CobB CobQ family
BL8807_RS08755	COG0745	RESPONSE REGULATOR receiver
BL8807_RS08760	COG2205	protein histidine kinase activity
BL8807_RS08770	COG1136	(ABC) transporter
BL8807_RS08775	COG0242	peptide deformylase activity
BL8807_RS08785	COG2755	lipolytic protein G-D-S-L family
BL8807_RS08785	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
BL8807_RS08805	COG0799	negative regulation of ribosome biogenesis
BL8807_RS08840	COG0492	ferredoxin-NADP+ reductase activity
BL8807_RS08850	COG2184	nucleotidyltransferase activity
BL8807_RS08880	COG0598	Magnesium transport protein CorA
BL8807_RS08890	COG1131	(ABC) transporter
BL8807_RS08915	COG2197	response regulator
BL8807_RS08935	COG0802	atpase or kinase
BL8807_RS08945	COG0456	acetyltransferase
BL8807_RS09005	COG1192	Involved in chromosome partitioning
BL8807_RS09075	COG0670	Belongs to the BI1 family
BL8807_RS09180	COG0551	DNA topoisomerase type I activity
BL8807_RS09180	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BL8807_RS09210	COG3942	CHAP domain
BL8807_RS09280	COG1022	Amp-dependent synthetase and ligase
BL8807_RS09295	COG0516	GMP reductase activity
BL8807_RS09330	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BL8807_RS09335	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BL8807_RS09340	COG3231	kanamycin kinase activity
BL8807_RS09360	COG3177	Filamentation induced by cAMP protein fic
BL8807_RS09395	COG1876	peptidase activity
BL8807_RS09425	COG2197	response regulator
BL8807_RS09430	COG4585	Histidine kinase
BL8807_RS09440	COG4181	ATPase activity
BL8807_RS09445	COG0133	tryptophan synthase activity
BL8807_RS09460	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BL8807_RS09475	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BL8807_RS09495	COG1716	ATPase activity
BL8807_RS09565	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BL8807_RS09590	COG0045	succinate-CoA ligase (ADP-forming) activity
BL8807_RS09670	COG1136	(ABC) transporter
BL8807_RS09690	COG1136	(ABC) transporter
BL8807_RS09715	COG4868	Belongs to the UPF0371 family
BL8807_RS09745	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BL8807_RS09750	COG0436	Aminotransferase
BL8807_RS09760	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BL8807_RS09785	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BL8807_RS09795	COG2873	o-acetylhomoserine
BL8807_RS09850	COG2826	transposase and inactivated derivatives, IS30 family
BL8807_RS09885	COG0488	(ABC) transporter
BL8807_RS09895	COG0584	glycerophosphoryl diester phosphodiesterase
BL8807_RS09920	COG2361	Protein of unknown function DUF86
BL8807_RS09950	COG0577	efflux transmembrane transporter activity
BL8807_RS09975	COG0583	DNA-binding transcription factor activity
BL8807_RS09990	COG0167	dihydroorotate dehydrogenase activity
BL8807_RS09995	COG0543	2 iron, 2 sulfur cluster binding
BL8807_RS10000	COG0284	orotidine-5'-phosphate decarboxylase activity
BL8807_RS10005	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BL8807_RS10050	COG1119	ATPase activity
BL8807_RS10055	COG0297	glycogen (starch) synthase activity
BL8807_RS10085	COG0067	glutamate synthase
BL8807_RS10085	COG0070	glutamate synthase
BL8807_RS10085	COG0069	glutamate synthase activity
BL8807_RS10090	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BL8807_RS10115	COG2860	membrane
BL8807_RS10120	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BL8807_RS10145	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
BL8807_RS10155	COG1028	Short-chain dehydrogenase reductase Sdr
BL8807_RS10160	COG0583	DNA-binding transcription factor activity
BL8807_RS10165	COG1472	Belongs to the glycosyl hydrolase 3 family
BL8807_RS10170	COG1472	Belongs to the glycosyl hydrolase 3 family
BL8807_RS10205	COG5002	protein histidine kinase activity
BL8807_RS10205	COG3850	Histidine kinase
BL8807_RS10235	COG0537	adenosine 5'-monophosphoramidase activity
BL8807_RS10240	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BL8807_RS10260	COG2151	metal-sulfur cluster biosynthetic enzyme
BL8807_RS10265	COG0822	iron-sulfur transferase activity
BL8807_RS10275	COG0396	ATPase activity
BL8807_RS10280	COG0719	Fe-S assembly protein
BL8807_RS10290	COG1376	ErfK ybiS ycfS ynhG family protein
BL8807_RS10300	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BL8807_RS10345	COG0588	phosphoglycerate mutase activity
BL8807_RS10355	COG0577	efflux transmembrane transporter activity
BL8807_RS10355	COG1136	(ABC) transporter
BL8807_RS10395	COG1131	(ABC) transporter
BL8807_RS10400	COG4585	Histidine kinase
BL8807_RS10405	COG2197	response regulator
BL8807_RS10430	COG1396	sequence-specific DNA binding
BL8807_RS10440	COG1966	Carbon starvation protein
BL8807_RS10445	COG3279	Response regulator of the LytR AlgR family
BL8807_RS10455	COG1136	(ABC) transporter
BL8807_RS10455	COG0577	efflux transmembrane transporter activity
BL8807_RS10460	COG0577	efflux transmembrane transporter activity
BL8807_RS10485	COG1454	alcohol dehydrogenase
BL8807_RS10525	COG0789	Transcriptional regulator
BL8807_RS10530	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BL8807_RS10535	COG0656	L-ascorbic acid biosynthetic process
BL8807_RS10540	COG0583	DNA-binding transcription factor activity
BL8807_RS10545	COG2361	Protein of unknown function DUF86
BL8807_RS10565	COG1129	ABC transporter
BL8807_RS10575	COG4221	oxidoreductase activity
BL8807_RS10580	COG0477	Major facilitator Superfamily
BL8807_RS10600	COG1349	DNA-binding transcription factor activity
BL8807_RS10605	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BL8807_RS10615	COG2233	PERMEase
BL8807_RS10630	COG1174	glycine betaine transport
BL8807_RS10650	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BL8807_RS10655	COG3304	Inner membrane component domain
BL8807_RS10660	COG0702	epimerase
BL8807_RS10670	COG2207	Transcriptional regulator
BL8807_RS10680	COG0583	DNA-binding transcription factor activity
BL8807_RS10685	COG0012	GTP binding
BL8807_RS10690	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BL8807_RS10700	COG4585	Histidine kinase
BL8807_RS10705	COG2197	response regulator
BL8807_RS10715	COG0577	efflux transmembrane transporter activity
BL8807_RS10715	COG1136	(ABC) transporter
BL8807_RS10720	COG2873	o-acetylhomoserine
BL8807_RS10760	COG1611	Belongs to the LOG family
BL8807_RS10765	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
BL8807_RS10770	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
BL8807_RS10855	COG2801	Transposase and inactivated derivatives
BL8807_RS10860	COG1196	nuclear chromosome segregation
BL8807_RS10925	COG3956	TIGRFAM MazG family protein
BL8807_RS10955	COG1882	Formate acetyltransferase
BL8807_RS10965	COG1473	amidohydrolase
BL8807_RS10970	COG2011	ABC-type metal ion transport system permease component
BL8807_RS10985	COG0561	phosphatase activity
BL8807_RS11020	COG0583	DNA-binding transcription factor activity
BL8807_RS11025	COG0667	Aldo Keto reductase
BL8807_RS11035	COG0667	Aldo Keto reductase
BL8807_RS11045	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
BL8807_RS11055	COG0583	DNA-binding transcription factor activity
BL8807_RS11070	COG0667	Aldo Keto reductase
BL8807_RS11080	COG2249	NAD(P)H dehydrogenase (quinone) activity
BL8807_RS11105	COG0667	Aldo Keto reductase
BL8807_RS11110	COG0583	DNA-binding transcription factor activity
BL8807_RS11115	COG1472	Belongs to the glycosyl hydrolase 3 family
BL8807_RS11120	COG2272	Belongs to the type-B carboxylesterase lipase family
BL8807_RS11155	COG0656	L-ascorbic acid biosynthetic process
BL8807_RS11160	COG0583	DNA-binding transcription factor activity
BL8807_RS11165	COG1902	pentaerythritol trinitrate reductase activity
BL8807_RS11180	COG0667	Aldo Keto reductase
BL8807_RS11185	COG0656	L-ascorbic acid biosynthetic process
BL8807_RS11190	COG0583	DNA-binding transcription factor activity
BL8807_RS11195	COG0667	Aldo Keto reductase
BL8807_RS11210	COG0390	transport system, permease component
BL8807_RS11220	COG0745	RESPONSE REGULATOR receiver
BL8807_RS11225	COG5002	protein histidine kinase activity
BL8807_RS11230	COG0586	Pfam SNARE associated Golgi protein
BL8807_RS11285	COG1136	(ABC) transporter
BL8807_RS11285	COG0577	efflux transmembrane transporter activity
BL8807_RS11305	COG1136	(ABC) transporter
BL8807_RS11305	COG0577	efflux transmembrane transporter activity
BL8807_RS11310	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BL8807_RS11335	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BL8807_RS11360	COG1940	carbohydrate kinase activity
BL8807_RS11360	COG1846	Transcriptional regulator
BL8807_RS11365	COG1063	alcohol dehydrogenase
BL8807_RS11375	COG1454	alcohol dehydrogenase
BL8807_RS11375	COG1012	belongs to the aldehyde dehydrogenase family
BL8807_RS11385	COG3655	Transcriptional regulator
BL8807_RS11400	COG0187	DNA topoisomerase II activity
BL8807_RS11405	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BL8807_RS11415	COG0142	geranyltranstransferase activity
BL8807_RS11425	COG0204	Acyl-transferase
BL8807_RS11440	COG2721	sulfolactate sulfo-lyase activity
BL8807_RS11455	COG1028	Short-chain dehydrogenase reductase Sdr
BL8807_RS11460	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
BL8807_RS11475	COG1609	Transcriptional regulator
BL8807_RS11485	COG1904	glucuronate isomerase
BL8807_RS11495	COG0246	Mannitol dehydrogenase
BL8807_RS11515	COG0395	ABC-type sugar transport system, permease component
BL8807_RS11520	COG1175	transmembrane transport
BL8807_RS11530	COG1609	Transcriptional regulator
BL8807_RS11535	COG0800	Aldolase
BL8807_RS11540	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BL8807_RS11545	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BL8807_RS11555	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
BL8807_RS11570	COG2137	regulation of response to DNA damage stimulus
BL8807_RS11590	COG1396	sequence-specific DNA binding
BL8807_RS11595	COG1058	Belongs to the CinA family
BL8807_RS11595	COG1546	Belongs to the CinA family
BL8807_RS11625	COG2357	RelA SpoT domain protein
BL8807_RS11635	COG0531	amino acid
BL8807_RS11645	COG3250	beta-galactosidase activity
BL8807_RS11655	COG0670	Belongs to the BI1 family
BL8807_RS11670	COG2197	response regulator
BL8807_RS11685	COG1335	isochorismatase
BL8807_RS11700	COG1917	Cupin 2, conserved barrel domain protein
BL8807_RS11700	COG2207	Transcriptional regulator
BL8807_RS11705	COG0110	maltose O-acetyltransferase activity
BL8807_RS11715	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
BL8807_RS11745	COG0708	Exodeoxyribonuclease III
BL8807_RS11755	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BL8807_RS11760	COG0601	transmembrane transport
BL8807_RS11765	COG4166	transmembrane transport
BL8807_RS11785	COG0287	Prephenate dehydrogenase
BL8807_RS11800	COG1217	gtp-binding protein TYPA
BL8807_RS11805	COG0477	Major facilitator Superfamily
BL8807_RS11815	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BL8807_RS11845	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins