locus-tag	class	description
I3K78_RS00010	COG0592	DNA-directed DNA polymerase activity
I3K78_RS00025	COG0187	DNA topoisomerase II activity
I3K78_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I3K78_RS00035	COG3266	domain, Protein
I3K78_RS00045	COG4677	pectinesterase activity
I3K78_RS00050	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I3K78_RS00055	COG1522	sequence-specific DNA binding
I3K78_RS00060	COG0436	Aminotransferase
I3K78_RS00120	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I3K78_RS00125	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I3K78_RS00135	COG3265	gluconokinase activity
I3K78_RS00145	COG0783	Belongs to the Dps family
I3K78_RS00150	COG1253	flavin adenine dinucleotide binding
I3K78_RS00180	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
I3K78_RS00190	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I3K78_RS00205	COG0180	Tryptophanyl-tRNA synthetase
I3K78_RS00220	COG0058	SHG alpha-glucan phosphorylase activity
I3K78_RS00260	COG0515	serine threonine protein kinase
I3K78_RS00265	COG0768	penicillin binding
I3K78_RS00320	COG0071	Belongs to the small heat shock protein (HSP20) family
I3K78_RS00340	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
I3K78_RS00360	COG1216	Glycosyl transferase, family 2
I3K78_RS00390	COG0343	queuine tRNA-ribosyltransferase activity
I3K78_RS00425	COG0191	fructose-bisphosphate aldolase activity
I3K78_RS00500	COG3534	alpha-L-arabinofuranosidase
I3K78_RS00520	COG4974	Belongs to the 'phage' integrase family
I3K78_RS00555	COG0477	Major facilitator Superfamily
I3K78_RS00570	COG0366	Alpha amylase catalytic
I3K78_RS00595	COG1609	Transcriptional regulator
I3K78_RS00600	COG0395	ABC-type sugar transport system, permease component
I3K78_RS00625	COG0789	Transcriptional regulator
I3K78_RS00645	COG1028	Short-chain dehydrogenase reductase Sdr
I3K78_RS00650	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I3K78_RS00655	COG0586	Pfam SNARE associated Golgi protein
I3K78_RS00735	COG0527	aspartate kinase activity
I3K78_RS00770	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I3K78_RS00785	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I3K78_RS00785	COG1754	DNA topoisomerase type I activity
I3K78_RS00840	COG0676	glucose-6-phosphate 1-epimerase activity
I3K78_RS00875	COG0366	Alpha amylase catalytic
I3K78_RS00895	COG0672	)-iron permease
I3K78_RS00900	COG3470	protein probably involved in high-affinity Fe2 transport
I3K78_RS00910	COG0577	efflux transmembrane transporter activity
I3K78_RS00915	COG0577	efflux transmembrane transporter activity
I3K78_RS00955	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I3K78_RS00960	COG0363	glucosamine-6-phosphate deaminase activity
I3K78_RS00985	COG1215	transferase activity, transferring glycosyl groups
I3K78_RS00990	COG1309	transcriptional regulator
I3K78_RS01010	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I3K78_RS01020	COG0305	Participates in initiation and elongation during chromosome replication
I3K78_RS01025	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I3K78_RS01030	COG3442	glutamine amidotransferase
I3K78_RS01045	COG1609	Transcriptional regulator
I3K78_RS01055	COG1175	transmembrane transport
I3K78_RS01060	COG0395	ABC-type sugar transport system, permease component
I3K78_RS01080	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I3K78_RS01120	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I3K78_RS01125	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I3K78_RS01130	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I3K78_RS01140	COG1937	Protein conserved in bacteria
I3K78_RS01145	COG1322	Protein conserved in bacteria
I3K78_RS01155	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I3K78_RS01200	COG1605	Chorismate mutase
I3K78_RS01200	COG0287	Prephenate dehydrogenase
I3K78_RS01225	COG0745	RESPONSE REGULATOR receiver
I3K78_RS01245	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I3K78_RS01275	COG0356	it plays a direct role in the translocation of protons across the membrane
I3K78_RS01310	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I3K78_RS01320	COG0545	Peptidyl-prolyl cis-trans isomerase
I3K78_RS01350	COG0251	oxidation-reduction process
I3K78_RS01385	COG3842	ATPase activity
I3K78_RS01400	COG1027	Aspartate ammonia-lyase
I3K78_RS01415	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I3K78_RS01455	COG0798	PFAM Bile acid sodium symporter
I3K78_RS01470	COG0701	Predicted permease
I3K78_RS01475	COG0640	Transcriptional regulator
I3K78_RS01480	COG2270	Major facilitator Superfamily
I3K78_RS01485	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
I3K78_RS01485	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I3K78_RS01500	COG0742	ribosomal rna small subunit methyltransferase
I3K78_RS01510	COG0826	peptidase U32
I3K78_RS01515	COG1496	oxidoreductase activity
I3K78_RS01525	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
I3K78_RS01535	COG3579	cysteine-type endopeptidase activity
I3K78_RS01540	COG3579	cysteine-type endopeptidase activity
I3K78_RS01555	COG1653	transport
I3K78_RS01560	COG1175	transmembrane transport
I3K78_RS01565	COG0395	ABC-type sugar transport system, permease component
I3K78_RS01570	COG1554	hydrolase, family 65, central catalytic
I3K78_RS01580	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I3K78_RS01585	COG3250	beta-galactosidase activity
I3K78_RS01595	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I3K78_RS01600	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I3K78_RS01605	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I3K78_RS01610	COG5002	protein histidine kinase activity
I3K78_RS01615	COG0745	RESPONSE REGULATOR receiver
I3K78_RS01640	COG1704	LemA family
I3K78_RS01655	COG1957	nucleoside hydrolase
I3K78_RS01665	COG1837	Belongs to the UPF0109 family
I3K78_RS01695	COG0505	Belongs to the CarA family
I3K78_RS01700	COG0488	(ABC) transporter
I3K78_RS01715	COG0440	acetolactate synthase activity
I3K78_RS01755	COG0667	Aldo Keto reductase
I3K78_RS01795	COG2348	transferase activity, transferring amino-acyl groups
I3K78_RS01835	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I3K78_RS01840	COG1609	Transcriptional regulator
I3K78_RS01865	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I3K78_RS01875	COG0577	efflux transmembrane transporter activity
I3K78_RS01900	COG4988	ABC transporter
I3K78_RS01905	COG2814	Major facilitator Superfamily
I3K78_RS01910	COG1653	transport
I3K78_RS01915	COG1175	transmembrane transport
I3K78_RS01920	COG0395	ABC-type sugar transport system, permease component
I3K78_RS01945	COG0656	L-ascorbic acid biosynthetic process
I3K78_RS01970	COG2801	Transposase and inactivated derivatives
I3K78_RS01975	COG2814	Major facilitator Superfamily
I3K78_RS01995	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I3K78_RS02005	COG0438	transferase activity, transferring glycosyl groups
I3K78_RS02010	COG0438	transferase activity, transferring glycosyl groups
I3K78_RS02020	COG1216	Glycosyl transferase, family 2
I3K78_RS02070	COG2826	transposase and inactivated derivatives, IS30 family
I3K78_RS02090	COG3547	Transposase (IS116 IS110 IS902 family)
I3K78_RS02095	COG2826	transposase and inactivated derivatives, IS30 family
I3K78_RS02205	COG0489	protein tyrosine kinase activity
I3K78_RS02260	COG0095	Lipoate-protein ligase
I3K78_RS02270	COG4499	WXG100 protein secretion system (Wss), protein YukC
I3K78_RS02270	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I3K78_RS02275	COG1902	pentaerythritol trinitrate reductase activity
I3K78_RS02280	COG0167	dihydroorotate dehydrogenase activity
I3K78_RS02285	COG1349	DNA-binding transcription factor activity
I3K78_RS02295	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I3K78_RS02305	COG4209	transmembrane transport
I3K78_RS02310	COG0395	ABC-type sugar transport system, permease component
I3K78_RS02325	COG1621	beta-fructofuranosidase activity
I3K78_RS02370	COG2814	Major facilitator Superfamily
I3K78_RS02395	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I3K78_RS02445	COG0714	Associated with various cellular activities
I3K78_RS02485	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I3K78_RS02525	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I3K78_RS02530	COG2884	Cell division ATP-binding protein ftsE
I3K78_RS02535	COG2177	Part of the ABC transporter FtsEX involved in
I3K78_RS02540	COG3942	CHAP domain
I3K78_RS02540	COG1388	LysM domain
I3K78_RS02575	COG0564	pseudouridine synthase activity
I3K78_RS02585	COG1609	Transcriptional regulator
I3K78_RS02590	COG1175	transmembrane transport
I3K78_RS02595	COG0395	ABC-type sugar transport system, permease component
I3K78_RS02605	COG1609	Transcriptional regulator
I3K78_RS02610	COG3534	alpha-L-arabinofuranosidase
I3K78_RS02615	COG1653	transport
I3K78_RS02620	COG1653	transport
I3K78_RS02635	COG0747	negative chemotaxis
I3K78_RS02640	COG0601	transmembrane transport
I3K78_RS02645	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I3K78_RS02655	COG4608	Belongs to the ABC transporter superfamily
I3K78_RS02665	COG0626	cystathionine gamma-synthase activity
I3K78_RS02675	COG0514	ATP-dependent DNA helicase (RecQ)
I3K78_RS02690	COG0531	amino acid
I3K78_RS02695	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I3K78_RS02705	COG0358	DNA primase activity
I3K78_RS02730	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I3K78_RS02740	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I3K78_RS02755	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I3K78_RS02770	COG0577	efflux transmembrane transporter activity
I3K78_RS02770	COG1136	(ABC) transporter
I3K78_RS02780	COG0577	efflux transmembrane transporter activity
I3K78_RS02785	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I3K78_RS02795	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I3K78_RS02800	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I3K78_RS02825	COG1012	belongs to the aldehyde dehydrogenase family
I3K78_RS02855	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I3K78_RS02865	COG0402	S-adenosylhomocysteine deaminase activity
I3K78_RS02870	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I3K78_RS02875	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I3K78_RS02885	COG0667	Aldo Keto reductase
I3K78_RS02915	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I3K78_RS02930	COG0436	Aminotransferase
I3K78_RS02950	COG0385	Bile acid
I3K78_RS02980	COG0583	DNA-binding transcription factor activity
I3K78_RS03005	COG1063	alcohol dehydrogenase
I3K78_RS03050	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I3K78_RS03070	COG0110	maltose O-acetyltransferase activity
I3K78_RS03075	COG0110	maltose O-acetyltransferase activity
I3K78_RS03085	COG3250	beta-galactosidase activity
I3K78_RS03110	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I3K78_RS03115	COG4721	ABC-type cobalt transport system, permease component
I3K78_RS03120	COG1122	ATPase activity
I3K78_RS03130	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I3K78_RS03200	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I3K78_RS03205	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I3K78_RS03250	COG0569	domain protein
I3K78_RS03255	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I3K78_RS03265	COG0497	DNA recombination
I3K78_RS03270	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I3K78_RS03295	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I3K78_RS03320	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I3K78_RS03335	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I3K78_RS03335	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I3K78_RS03350	COG0667	Aldo Keto reductase
I3K78_RS03385	COG1760	l-serine dehydratase
I3K78_RS03395	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I3K78_RS03460	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I3K78_RS03470	COG2205	protein histidine kinase activity
I3K78_RS03475	COG0745	RESPONSE REGULATOR receiver
I3K78_RS03485	COG1329	Transcriptional regulator
I3K78_RS03500	COG1121	(ABC) transporter
I3K78_RS03505	COG0803	Belongs to the bacterial solute-binding protein 9 family
I3K78_RS03515	COG0539	negative regulation of cytoplasmic translation
I3K78_RS03535	COG0469	pyruvate kinase activity
I3K78_RS03540	COG0494	nUDIX hydrolase
I3K78_RS03560	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I3K78_RS03565	COG1051	belongs to the nudix hydrolase family
I3K78_RS03585	COG0519	Catalyzes the synthesis of GMP from XMP
I3K78_RS03595	COG3250	beta-galactosidase activity
I3K78_RS03635	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I3K78_RS03640	COG0280	phosphate acetyltransferase
I3K78_RS03640	COG0857	belongs to the CobB CobQ family
I3K78_RS03655	COG0406	alpha-ribazole phosphatase activity
I3K78_RS03660	COG0799	negative regulation of ribosome biogenesis
I3K78_RS03680	COG2755	lipolytic protein G-D-S-L family
I3K78_RS03680	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I3K78_RS03745	COG2011	ABC-type metal ion transport system permease component
I3K78_RS03750	COG1473	amidohydrolase
I3K78_RS03765	COG1882	Formate acetyltransferase
I3K78_RS03770	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I3K78_RS03830	COG1611	Belongs to the LOG family
I3K78_RS03850	COG1053	succinate dehydrogenase
I3K78_RS03855	COG0758	DNA mediated transformation
I3K78_RS03875	COG2873	o-acetylhomoserine
I3K78_RS03880	COG1136	(ABC) transporter
I3K78_RS03885	COG1136	(ABC) transporter
I3K78_RS03885	COG0577	efflux transmembrane transporter activity
I3K78_RS03890	COG2197	response regulator
I3K78_RS03895	COG4585	Histidine kinase
I3K78_RS03905	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I3K78_RS03910	COG0012	GTP binding
I3K78_RS03915	COG4974	Belongs to the 'phage' integrase family
I3K78_RS03965	COG2814	Major facilitator Superfamily
I3K78_RS03980	COG2239	Acts as a magnesium transporter
I3K78_RS03990	COG0515	serine threonine protein kinase
I3K78_RS03990	COG2815	serine threonine protein kinase
I3K78_RS04030	COG2233	PERMEase
I3K78_RS04035	COG0513	Belongs to the DEAD box helicase family
I3K78_RS04040	COG1309	transcriptional regulator
I3K78_RS04050	COG1966	Carbon starvation protein
I3K78_RS04060	COG0306	phosphate transporter
I3K78_RS04070	COG2197	response regulator
I3K78_RS04075	COG4585	Histidine kinase
I3K78_RS04080	COG1131	(ABC) transporter
I3K78_RS04125	COG3655	Transcriptional regulator
I3K78_RS04155	COG1136	(ABC) transporter
I3K78_RS04155	COG0577	efflux transmembrane transporter activity
I3K78_RS04165	COG2755	lipolytic protein G-D-S-L family
I3K78_RS04165	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I3K78_RS04170	COG0588	phosphoglycerate mutase activity
I3K78_RS04215	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I3K78_RS04235	COG0719	Fe-S assembly protein
I3K78_RS04240	COG0396	ATPase activity
I3K78_RS04245	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I3K78_RS04255	COG2151	metal-sulfur cluster biosynthetic enzyme
I3K78_RS04275	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I3K78_RS04280	COG0537	adenosine 5'-monophosphoramidase activity
I3K78_RS04285	COG1702	phosphate starvation-inducible protein PhoH
I3K78_RS04310	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
I3K78_RS04335	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I3K78_RS04345	COG2860	membrane
I3K78_RS04370	COG1929	Belongs to the glycerate kinase type-1 family
I3K78_RS04385	COG1609	Transcriptional regulator
I3K78_RS04400	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I3K78_RS04405	COG1609	Transcriptional regulator
I3K78_RS04410	COG0069	glutamate synthase activity
I3K78_RS04410	COG0070	glutamate synthase
I3K78_RS04410	COG0067	glutamate synthase
I3K78_RS04420	COG4166	transmembrane transport
I3K78_RS04435	COG0297	glycogen (starch) synthase activity
I3K78_RS04440	COG1119	ATPase activity
I3K78_RS04445	COG0561	phosphatase activity
I3K78_RS04450	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I3K78_RS04515	COG4221	oxidoreductase activity
I3K78_RS04545	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
I3K78_RS04550	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
I3K78_RS04560	COG3942	CHAP domain
I3K78_RS04560	COG1388	LysM domain
I3K78_RS04580	COG1063	alcohol dehydrogenase
I3K78_RS04590	COG4989	oxidoreductase activity
I3K78_RS04605	COG0588	phosphoglycerate mutase activity
I3K78_RS04615	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I3K78_RS04640	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I3K78_RS04645	COG0284	orotidine-5'-phosphate decarboxylase activity
I3K78_RS04650	COG0543	2 iron, 2 sulfur cluster binding
I3K78_RS04655	COG0167	dihydroorotate dehydrogenase activity
I3K78_RS04675	COG0583	DNA-binding transcription factor activity
I3K78_RS04700	COG3189	MarR family transcriptional regulator
I3K78_RS04725	COG1122	ATPase activity
I3K78_RS04745	COG0681	Belongs to the peptidase S26 family
I3K78_RS04755	COG0833	amino acid
I3K78_RS04780	COG1051	belongs to the nudix hydrolase family
I3K78_RS04855	COG0133	tryptophan synthase activity
I3K78_RS04870	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I3K78_RS04885	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I3K78_RS04905	COG1716	ATPase activity
I3K78_RS04965	COG1187	pseudouridine synthase activity
I3K78_RS04970	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I3K78_RS04995	COG0045	succinate-CoA ligase (ADP-forming) activity
I3K78_RS05095	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I3K78_RS05110	COG0436	Aminotransferase
I3K78_RS05125	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I3K78_RS05150	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I3K78_RS05200	COG1129	ABC transporter
I3K78_RS05215	COG4221	oxidoreductase activity
I3K78_RS05220	COG0488	(ABC) transporter
I3K78_RS05245	COG0693	protein deglycase activity
I3K78_RS05255	COG0575	Belongs to the CDS family
I3K78_RS05295	COG0516	GMP reductase activity
I3K78_RS05365	COG1192	Involved in chromosome partitioning
I3K78_RS05515	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I3K78_RS05515	COG0551	DNA topoisomerase type I activity
I3K78_RS05535	COG3942	CHAP domain
I3K78_RS05600	COG0456	acetyltransferase
I3K78_RS05610	COG0802	atpase or kinase
I3K78_RS05620	COG1228	amidohydrolase
I3K78_RS05630	COG1555	photosystem II stabilization
I3K78_RS05630	COG1596	polysaccharide export
I3K78_RS05640	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I3K78_RS05645	COG0598	Magnesium transport protein CorA
I3K78_RS05650	COG0406	alpha-ribazole phosphatase activity
I3K78_RS05690	COG2801	Transposase and inactivated derivatives
I3K78_RS05695	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I3K78_RS05720	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I3K78_RS05730	COG1201	RNA secondary structure unwinding
I3K78_RS05735	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I3K78_RS05745	COG0187	DNA topoisomerase II activity
I3K78_RS05750	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I3K78_RS05760	COG0142	geranyltranstransferase activity
I3K78_RS05780	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I3K78_RS05795	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I3K78_RS05820	COG1396	sequence-specific DNA binding
I3K78_RS05825	COG1058	Belongs to the CinA family
I3K78_RS05825	COG1546	Belongs to the CinA family
I3K78_RS05855	COG2357	RelA SpoT domain protein
I3K78_RS05865	COG0670	Belongs to the BI1 family
I3K78_RS05880	COG2197	response regulator
I3K78_RS05935	COG0708	Exodeoxyribonuclease III
I3K78_RS05945	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I3K78_RS05950	COG0601	transmembrane transport
I3K78_RS05955	COG4166	transmembrane transport
I3K78_RS05970	COG0287	Prephenate dehydrogenase
I3K78_RS05975	COG1605	Chorismate mutase
I3K78_RS05975	COG0077	Prephenate dehydratase
I3K78_RS05985	COG1217	gtp-binding protein TYPA
I3K78_RS05990	COG0477	Major facilitator Superfamily
I3K78_RS05995	COG1104	cysteine desulfurase activity
I3K78_RS06005	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I3K78_RS06010	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I3K78_RS06020	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I3K78_RS06025	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I3K78_RS06035	COG0577	efflux transmembrane transporter activity
I3K78_RS06035	COG1136	(ABC) transporter
I3K78_RS06055	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I3K78_RS06080	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I3K78_RS06090	COG2017	converts alpha-aldose to the beta-anomer
I3K78_RS06095	COG2017	converts alpha-aldose to the beta-anomer
I3K78_RS06105	COG1595	DNA-templated transcription, initiation
I3K78_RS06120	COG1196	nuclear chromosome segregation
I3K78_RS06125	COG0285	dihydrofolate synthase activity
I3K78_RS06135	COG0006	proline dipeptidase activity
I3K78_RS06155	COG0601	transmembrane transport
I3K78_RS06160	COG4166	transmembrane transport
I3K78_RS06180	COG1940	carbohydrate kinase activity
I3K78_RS06225	COG1472	Belongs to the glycosyl hydrolase 3 family
I3K78_RS06235	COG0395	ABC-type sugar transport system, permease component
I3K78_RS06240	COG1175	transmembrane transport
I3K78_RS06270	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
I3K78_RS06310	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I3K78_RS06320	COG0768	penicillin binding
I3K78_RS06345	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I3K78_RS06375	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I3K78_RS06380	COG2813	Specifically methylates the guanine in position
I3K78_RS06385	COG1643	Atp-dependent helicase
I3K78_RS06400	COG0174	glutamine synthetase
I3K78_RS06450	COG0656	L-ascorbic acid biosynthetic process
I3K78_RS06480	COG4716	Myosin-crossreactive antigen
I3K78_RS06490	COG0587	DNA-directed DNA polymerase activity
I3K78_RS06530	COG1074	ATP-dependent DNA helicase activity
I3K78_RS06535	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
I3K78_RS06565	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I3K78_RS06570	COG1136	(ABC) transporter
I3K78_RS06600	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I3K78_RS06630	COG0352	thiamine-phosphate diphosphorylase activity
I3K78_RS06630	COG0351	phosphomethylpyrimidine kinase
I3K78_RS06640	COG2271	Major facilitator Superfamily
I3K78_RS06675	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I3K78_RS06685	COG1957	nucleoside hydrolase
I3K78_RS06730	COG3480	Lon protease (S16) C-terminal proteolytic domain
I3K78_RS06765	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I3K78_RS06785	COG2873	o-acetylhomoserine
I3K78_RS06810	COG0626	cystathionine gamma-synthase activity
I3K78_RS06815	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I3K78_RS06820	COG1126	abc transporter atp-binding protein
I3K78_RS06825	COG0765	amino acid transport
I3K78_RS06840	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I3K78_RS06855	COG0284	orotidine-5'-phosphate decarboxylase activity
I3K78_RS06880	COG0577	efflux transmembrane transporter activity
I3K78_RS06880	COG1136	(ABC) transporter
I3K78_RS06885	COG0390	transport system, permease component
I3K78_RS06890	COG1376	ErfK ybiS ycfS ynhG family protein
I3K78_RS06900	COG4106	trans-aconitate 2-methyltransferase activity
I3K78_RS06915	COG1250	3-hydroxyacyl-CoA dehydrogenase
I3K78_RS06920	COG1501	Belongs to the glycosyl hydrolase 31 family
I3K78_RS06935	COG0395	ABC-type sugar transport system, permease component
I3K78_RS06955	COG2826	transposase and inactivated derivatives, IS30 family
I3K78_RS06980	COG1122	ATPase activity
I3K78_RS07035	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I3K78_RS07040	COG2814	Major facilitator Superfamily
I3K78_RS07075	COG0745	RESPONSE REGULATOR receiver
I3K78_RS07085	COG4581	dead DEAH box helicase
I3K78_RS07090	COG2326	polyphosphate kinase activity
I3K78_RS07110	COG0765	amino acid transport
I3K78_RS07115	COG0765	amino acid transport
I3K78_RS07120	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I3K78_RS07125	COG1126	abc transporter atp-binding protein
I3K78_RS07145	COG1196	nuclear chromosome segregation
I3K78_RS07170	COG0402	S-adenosylhomocysteine deaminase activity
I3K78_RS07180	COG0589	response to stress
I3K78_RS07190	COG1278	Cold shock
I3K78_RS07195	COG2205	protein histidine kinase activity
I3K78_RS07200	COG0745	RESPONSE REGULATOR receiver
I3K78_RS07220	COG1278	Cold shock
I3K78_RS07235	COG0714	Associated with various cellular activities
I3K78_RS07285	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I3K78_RS07315	COG4122	O-methyltransferase activity
I3K78_RS07325	COG0586	Pfam SNARE associated Golgi protein
I3K78_RS07330	COG0560	Phosphoserine phosphatase
I3K78_RS07335	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I3K78_RS07410	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I3K78_RS07420	COG1609	Transcriptional regulator
I3K78_RS07430	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I3K78_RS07435	COG1979	alcohol dehydrogenase
I3K78_RS07440	COG0546	phosphoglycolate phosphatase activity
I3K78_RS07450	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I3K78_RS07455	COG0135	phosphoribosylanthranilate isomerase activity
I3K78_RS07460	COG1122	ATPase activity
I3K78_RS07485	COG1132	(ABC) transporter
I3K78_RS07490	COG1132	(ABC) transporter
I3K78_RS07500	COG1472	Belongs to the glycosyl hydrolase 3 family
I3K78_RS07530	COG1609	Transcriptional regulator
I3K78_RS07540	COG0154	amidase activity
I3K78_RS07550	COG2182	Extracellular solute-binding protein
I3K78_RS07590	COG1309	transcriptional regulator
I3K78_RS07605	COG0602	queuosine metabolic process
I3K78_RS07610	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I3K78_RS07610	COG1328	CTP reductase activity
I3K78_RS07620	COG1570	exodeoxyribonuclease VII activity
I3K78_RS07625	COG1722	exodeoxyribonuclease VII activity
I3K78_RS07630	COG2249	NAD(P)H dehydrogenase (quinone) activity
I3K78_RS07635	COG1022	Amp-dependent synthetase and ligase
I3K78_RS07640	COG1970	mechanosensitive ion channel activity
I3K78_RS07665	COG0248	Ppx GppA phosphatase
I3K78_RS07670	COG0436	Aminotransferase
I3K78_RS07730	COG3590	peptidase
I3K78_RS07755	COG1355	regulation of microtubule-based process
I3K78_RS07760	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I3K78_RS07775	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I3K78_RS07780	COG0009	L-threonylcarbamoyladenylate synthase
I3K78_RS07785	COG0110	maltose O-acetyltransferase activity
I3K78_RS07840	COG1070	Carbohydrate kinase
I3K78_RS07870	COG3507	Belongs to the glycosyl hydrolase 43 family
I3K78_RS07875	COG3507	Belongs to the glycosyl hydrolase 43 family
I3K78_RS07880	COG0395	ABC-type sugar transport system, permease component
I3K78_RS07885	COG1175	transmembrane transport
I3K78_RS07895	COG1609	Transcriptional regulator
I3K78_RS07900	COG1979	alcohol dehydrogenase
I3K78_RS07910	COG2814	Major facilitator Superfamily
I3K78_RS07915	COG2814	Major facilitator Superfamily
I3K78_RS07925	COG0242	peptide deformylase activity
I3K78_RS07935	COG2814	Major facilitator Superfamily
I3K78_RS07950	COG4214	carbohydrate transport
I3K78_RS07970	COG1129	ABC transporter
I3K78_RS07975	COG1940	carbohydrate kinase activity
I3K78_RS07990	COG1946	Acyl-CoA thioesterase
I3K78_RS08000	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I3K78_RS08005	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I3K78_RS08015	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I3K78_RS08020	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
I3K78_RS08060	COG1454	alcohol dehydrogenase
I3K78_RS08065	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I3K78_RS08080	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I3K78_RS08095	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I3K78_RS08100	COG1687	branched-chain amino acid
I3K78_RS08105	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I3K78_RS08125	COG0589	response to stress
I3K78_RS08130	COG0791	NLP P60 protein
I3K78_RS08140	COG1705	Flagellar rod assembly protein muramidase FlgJ
I3K78_RS08140	COG3942	CHAP domain
I3K78_RS08145	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I3K78_RS08155	COG5002	protein histidine kinase activity
I3K78_RS08160	COG0704	Plays a role in the regulation of phosphate uptake
I3K78_RS08170	COG1575	Belongs to the MenA family. Type 1 subfamily
I3K78_RS08175	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I3K78_RS08185	COG2814	Major facilitator Superfamily
I3K78_RS08220	COG2197	response regulator
I3K78_RS08245	COG0395	ABC-type sugar transport system, permease component
I3K78_RS08250	COG1175	transmembrane transport
I3K78_RS08275	COG1803	Methylglyoxal synthase
I3K78_RS08275	COG1597	lipid kinase activity
I3K78_RS08280	COG3711	transcriptional antiterminator
I3K78_RS08310	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I3K78_RS08320	COG0328	RNA-DNA hybrid ribonuclease activity
I3K78_RS08345	COG0196	riboflavin kinase activity
I3K78_RS08380	COG3534	alpha-L-arabinofuranosidase
I3K78_RS08395	COG2308	Evidence 4 Homologs of previously reported genes of
I3K78_RS08500	COG0255	Belongs to the universal ribosomal protein uL29 family
I3K78_RS08555	COG1012	belongs to the aldehyde dehydrogenase family
I3K78_RS08555	COG1454	alcohol dehydrogenase
I3K78_RS08570	COG1063	alcohol dehydrogenase
I3K78_RS08590	COG1063	alcohol dehydrogenase
I3K78_RS08620	COG1739	Uncharacterized protein family UPF0029
I3K78_RS08625	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I3K78_RS08645	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I3K78_RS08660	COG0531	amino acid
I3K78_RS08665	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I3K78_RS08755	COG2252	PERMEase
I3K78_RS08775	COG3507	Belongs to the glycosyl hydrolase 43 family
I3K78_RS08780	COG3507	Belongs to the glycosyl hydrolase 43 family
I3K78_RS08835	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I3K78_RS08840	COG4770	biotin carboxylase activity
I3K78_RS08845	COG1268	BioY protein
I3K78_RS08900	COG0250	Participates in transcription elongation, termination and antitermination
I3K78_RS08905	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I3K78_RS08915	COG0436	Aminotransferase
I3K78_RS08940	COG1530	ribonuclease E activity
I3K78_RS08945	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I3K78_RS08975	COG0083	homoserine kinase activity
I3K78_RS08980	COG0460	homoserine dehydrogenase
I3K78_RS08995	COG1309	transcriptional regulator
I3K78_RS09015	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I3K78_RS09020	COG0446	pyridine nucleotide-disulphide oxidoreductase
I3K78_RS09050	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I3K78_RS09055	COG0406	alpha-ribazole phosphatase activity
I3K78_RS09055	COG0494	nUDIX hydrolase
I3K78_RS09080	COG0584	glycerophosphoryl diester phosphodiesterase
I3K78_RS09095	COG2986	histidine ammonia-lyase
I3K78_RS09110	COG0179	Fumarylacetoacetate (FAA) hydrolase
I3K78_RS09130	COG1088	dTDP-glucose 4,6-dehydratase activity
I3K78_RS09145	COG1216	Glycosyl transferase, family 2
I3K78_RS09170	COG1216	Glycosyl transferase, family 2
I3K78_RS09265	COG0860	N-Acetylmuramoyl-L-alanine amidase
I3K78_RS09265	COG2247	cell wall binding repeat
I3K78_RS09275	COG0463	Glycosyl transferase, family 2
I3K78_RS09305	COG1129	ABC transporter
I3K78_RS09325	COG0084	hydrolase, TatD family'
I3K78_RS09335	COG1132	(ABC) transporter
I3K78_RS09340	COG1132	(ABC) transporter
I3K78_RS09350	COG1609	Transcriptional regulator
I3K78_RS09410	COG1132	(ABC) transporter
I3K78_RS09420	COG1846	Transcriptional regulator
I3K78_RS09445	COG1113	amino acid transport
I3K78_RS09455	COG0577	efflux transmembrane transporter activity
I3K78_RS09455	COG1136	(ABC) transporter
I3K78_RS09465	COG1113	amino acid transport
I3K78_RS09500	COG1609	Transcriptional regulator
I3K78_RS09510	COG0588	phosphoglycerate mutase activity
I3K78_RS09520	COG0778	Nitroreductase
I3K78_RS09570	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I3K78_RS09575	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I3K78_RS09580	COG0366	Alpha amylase catalytic
I3K78_RS09590	COG0395	ABC-type sugar transport system, permease component
I3K78_RS09595	COG1175	transmembrane transport
I3K78_RS09615	COG0590	tRNA wobble adenosine to inosine editing
I3K78_RS09615	COG0037	tRNA processing
I3K78_RS09620	COG0025	NhaP-type Na H and K H
I3K78_RS09645	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I3K78_RS09660	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I3K78_RS09695	COG3842	ATPase activity
I3K78_RS09700	COG1215	transferase activity, transferring glycosyl groups
I3K78_RS09710	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I3K78_RS09735	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I3K78_RS09765	COG3583	domain protein
I3K78_RS09785	COG0617	tRNA 3'-terminal CCA addition
I3K78_RS09810	COG1475	DNA binding
I3K78_RS09815	COG1192	Involved in chromosome partitioning
I3K78_RS10260	COG1192	Involved in chromosome partitioning
I3K78_RS10345	COG0305	Participates in initiation and elongation during chromosome replication
I3K78_RS10380	COG1397	ADP-ribosylglycohydrolase
I3K78_RS10660	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I3K78_RS10670	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I3K78_RS10735	COG0675	Transposase, IS605 OrfB family
I3K78_RS10770	COG3550	peptidyl-serine autophosphorylation
I3K78_RS10855	COG1002	Type II restriction enzyme, methylase subunits
I3K78_RS10900	COG1396	sequence-specific DNA binding
I3K78_RS10905	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
I3K78_RS10940	COG3942	CHAP domain
I3K78_RS10940	COG1388	LysM domain
I3K78_RS10960	COG3764	Sortase (surface protein transpeptidase)
I3K78_RS11055	COG3655	Transcriptional regulator
I3K78_RS11060	COG1316	TRANSCRIPTIONal
I3K78_RS11090	COG4974	Belongs to the 'phage' integrase family
I3K78_RS11235	COG0675	Transposase, IS605 OrfB family