locus-tag	class	description
I3K77_RS00010	COG0592	DNA-directed DNA polymerase activity
I3K77_RS00025	COG0187	DNA topoisomerase II activity
I3K77_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I3K77_RS00035	COG3266	domain, Protein
I3K77_RS00045	COG4677	pectinesterase activity
I3K77_RS00050	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I3K77_RS00055	COG1522	sequence-specific DNA binding
I3K77_RS00060	COG0436	Aminotransferase
I3K77_RS00115	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I3K77_RS00120	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I3K77_RS00130	COG3265	gluconokinase activity
I3K77_RS00140	COG0783	Belongs to the Dps family
I3K77_RS00145	COG1253	flavin adenine dinucleotide binding
I3K77_RS00175	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
I3K77_RS00185	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I3K77_RS00200	COG0180	Tryptophanyl-tRNA synthetase
I3K77_RS00215	COG0058	SHG alpha-glucan phosphorylase activity
I3K77_RS00255	COG0515	serine threonine protein kinase
I3K77_RS00260	COG0768	penicillin binding
I3K77_RS00315	COG0071	Belongs to the small heat shock protein (HSP20) family
I3K77_RS00335	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
I3K77_RS00355	COG1216	Glycosyl transferase, family 2
I3K77_RS00380	COG0343	queuine tRNA-ribosyltransferase activity
I3K77_RS00415	COG0191	fructose-bisphosphate aldolase activity
I3K77_RS00490	COG3534	alpha-L-arabinofuranosidase
I3K77_RS00510	COG4974	Belongs to the 'phage' integrase family
I3K77_RS00545	COG0477	Major facilitator Superfamily
I3K77_RS00560	COG0366	Alpha amylase catalytic
I3K77_RS00585	COG1609	Transcriptional regulator
I3K77_RS00590	COG0395	ABC-type sugar transport system, permease component
I3K77_RS00615	COG0789	Transcriptional regulator
I3K77_RS00635	COG1028	Short-chain dehydrogenase reductase Sdr
I3K77_RS00640	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I3K77_RS00645	COG0586	Pfam SNARE associated Golgi protein
I3K77_RS00720	COG0527	aspartate kinase activity
I3K77_RS00755	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I3K77_RS00770	COG1754	DNA topoisomerase type I activity
I3K77_RS00770	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I3K77_RS00825	COG0676	glucose-6-phosphate 1-epimerase activity
I3K77_RS00860	COG0366	Alpha amylase catalytic
I3K77_RS00880	COG0672	)-iron permease
I3K77_RS00885	COG3470	protein probably involved in high-affinity Fe2 transport
I3K77_RS00895	COG0577	efflux transmembrane transporter activity
I3K77_RS00900	COG0577	efflux transmembrane transporter activity
I3K77_RS00940	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I3K77_RS00945	COG0363	glucosamine-6-phosphate deaminase activity
I3K77_RS00970	COG1215	transferase activity, transferring glycosyl groups
I3K77_RS00975	COG1309	transcriptional regulator
I3K77_RS00995	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I3K77_RS01005	COG0305	Participates in initiation and elongation during chromosome replication
I3K77_RS01010	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I3K77_RS01015	COG3442	glutamine amidotransferase
I3K77_RS01030	COG1609	Transcriptional regulator
I3K77_RS01040	COG1175	transmembrane transport
I3K77_RS01045	COG0395	ABC-type sugar transport system, permease component
I3K77_RS01065	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I3K77_RS01105	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I3K77_RS01110	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I3K77_RS01115	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I3K77_RS01125	COG1937	Protein conserved in bacteria
I3K77_RS01130	COG1322	Protein conserved in bacteria
I3K77_RS01140	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I3K77_RS01185	COG1605	Chorismate mutase
I3K77_RS01185	COG0287	Prephenate dehydrogenase
I3K77_RS01210	COG0745	RESPONSE REGULATOR receiver
I3K77_RS01230	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I3K77_RS01260	COG0356	it plays a direct role in the translocation of protons across the membrane
I3K77_RS01295	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I3K77_RS01305	COG0545	Peptidyl-prolyl cis-trans isomerase
I3K77_RS01335	COG0251	oxidation-reduction process
I3K77_RS01370	COG3842	ATPase activity
I3K77_RS01385	COG1027	Aspartate ammonia-lyase
I3K77_RS01400	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I3K77_RS01440	COG0798	PFAM Bile acid sodium symporter
I3K77_RS01455	COG0701	Predicted permease
I3K77_RS01460	COG0640	Transcriptional regulator
I3K77_RS01465	COG2270	Major facilitator Superfamily
I3K77_RS01470	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I3K77_RS01470	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
I3K77_RS01485	COG0742	ribosomal rna small subunit methyltransferase
I3K77_RS01495	COG0826	peptidase U32
I3K77_RS01500	COG1496	oxidoreductase activity
I3K77_RS01510	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
I3K77_RS01520	COG3579	cysteine-type endopeptidase activity
I3K77_RS01525	COG3579	cysteine-type endopeptidase activity
I3K77_RS01540	COG1653	transport
I3K77_RS01545	COG1175	transmembrane transport
I3K77_RS01550	COG0395	ABC-type sugar transport system, permease component
I3K77_RS01555	COG1554	hydrolase, family 65, central catalytic
I3K77_RS01565	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I3K77_RS01570	COG3250	beta-galactosidase activity
I3K77_RS01580	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I3K77_RS01585	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I3K77_RS01590	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I3K77_RS01595	COG5002	protein histidine kinase activity
I3K77_RS01600	COG0745	RESPONSE REGULATOR receiver
I3K77_RS01625	COG1704	LemA family
I3K77_RS01640	COG1957	nucleoside hydrolase
I3K77_RS01650	COG1837	Belongs to the UPF0109 family
I3K77_RS01680	COG0505	Belongs to the CarA family
I3K77_RS01685	COG0488	(ABC) transporter
I3K77_RS01700	COG0440	acetolactate synthase activity
I3K77_RS01740	COG0667	Aldo Keto reductase
I3K77_RS01780	COG2348	transferase activity, transferring amino-acyl groups
I3K77_RS01820	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I3K77_RS01825	COG1609	Transcriptional regulator
I3K77_RS01850	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I3K77_RS01860	COG0577	efflux transmembrane transporter activity
I3K77_RS01885	COG4988	ABC transporter
I3K77_RS01890	COG2814	Major facilitator Superfamily
I3K77_RS01895	COG1653	transport
I3K77_RS01900	COG1175	transmembrane transport
I3K77_RS01905	COG0395	ABC-type sugar transport system, permease component
I3K77_RS01930	COG0656	L-ascorbic acid biosynthetic process
I3K77_RS01955	COG2801	Transposase and inactivated derivatives
I3K77_RS01960	COG2814	Major facilitator Superfamily
I3K77_RS01985	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I3K77_RS01995	COG0438	transferase activity, transferring glycosyl groups
I3K77_RS02000	COG0438	transferase activity, transferring glycosyl groups
I3K77_RS02010	COG1216	Glycosyl transferase, family 2
I3K77_RS02060	COG2826	transposase and inactivated derivatives, IS30 family
I3K77_RS02080	COG3547	Transposase (IS116 IS110 IS902 family)
I3K77_RS02085	COG2826	transposase and inactivated derivatives, IS30 family
I3K77_RS02195	COG0489	protein tyrosine kinase activity
I3K77_RS02250	COG0095	Lipoate-protein ligase
I3K77_RS02260	COG4499	WXG100 protein secretion system (Wss), protein YukC
I3K77_RS02260	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I3K77_RS02265	COG1902	pentaerythritol trinitrate reductase activity
I3K77_RS02270	COG0167	dihydroorotate dehydrogenase activity
I3K77_RS02275	COG1349	DNA-binding transcription factor activity
I3K77_RS02285	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I3K77_RS02295	COG4209	transmembrane transport
I3K77_RS02300	COG0395	ABC-type sugar transport system, permease component
I3K77_RS02315	COG1621	beta-fructofuranosidase activity
I3K77_RS02360	COG2814	Major facilitator Superfamily
I3K77_RS02385	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I3K77_RS02435	COG0714	Associated with various cellular activities
I3K77_RS02475	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I3K77_RS02515	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I3K77_RS02520	COG2884	Cell division ATP-binding protein ftsE
I3K77_RS02525	COG2177	Part of the ABC transporter FtsEX involved in
I3K77_RS02530	COG1388	LysM domain
I3K77_RS02530	COG3942	CHAP domain
I3K77_RS02565	COG0564	pseudouridine synthase activity
I3K77_RS02575	COG1609	Transcriptional regulator
I3K77_RS02580	COG1175	transmembrane transport
I3K77_RS02585	COG0395	ABC-type sugar transport system, permease component
I3K77_RS02595	COG1609	Transcriptional regulator
I3K77_RS02600	COG3534	alpha-L-arabinofuranosidase
I3K77_RS02605	COG1653	transport
I3K77_RS02610	COG1653	transport
I3K77_RS02625	COG0747	negative chemotaxis
I3K77_RS02630	COG0601	transmembrane transport
I3K77_RS02635	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I3K77_RS02645	COG4608	Belongs to the ABC transporter superfamily
I3K77_RS02655	COG0626	cystathionine gamma-synthase activity
I3K77_RS02665	COG0514	ATP-dependent DNA helicase (RecQ)
I3K77_RS02680	COG0531	amino acid
I3K77_RS02685	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I3K77_RS02695	COG0358	DNA primase activity
I3K77_RS02720	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I3K77_RS02730	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I3K77_RS02745	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I3K77_RS02760	COG0577	efflux transmembrane transporter activity
I3K77_RS02760	COG1136	(ABC) transporter
I3K77_RS02770	COG0577	efflux transmembrane transporter activity
I3K77_RS02775	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I3K77_RS02785	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I3K77_RS02790	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I3K77_RS02815	COG1012	belongs to the aldehyde dehydrogenase family
I3K77_RS02845	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I3K77_RS02855	COG0402	S-adenosylhomocysteine deaminase activity
I3K77_RS02860	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
I3K77_RS02865	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I3K77_RS02875	COG0667	Aldo Keto reductase
I3K77_RS02905	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I3K77_RS02935	COG0385	Bile acid
I3K77_RS02965	COG0583	DNA-binding transcription factor activity
I3K77_RS02990	COG1063	alcohol dehydrogenase
I3K77_RS03030	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I3K77_RS03050	COG0110	maltose O-acetyltransferase activity
I3K77_RS03055	COG0110	maltose O-acetyltransferase activity
I3K77_RS03065	COG3250	beta-galactosidase activity
I3K77_RS03090	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I3K77_RS03095	COG4721	ABC-type cobalt transport system, permease component
I3K77_RS03100	COG1122	ATPase activity
I3K77_RS03110	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I3K77_RS03180	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I3K77_RS03185	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I3K77_RS03230	COG0569	domain protein
I3K77_RS03235	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I3K77_RS03245	COG0497	DNA recombination
I3K77_RS03250	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I3K77_RS03275	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I3K77_RS03300	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I3K77_RS03315	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I3K77_RS03315	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I3K77_RS03330	COG0667	Aldo Keto reductase
I3K77_RS03365	COG1760	l-serine dehydratase
I3K77_RS03375	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I3K77_RS03440	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I3K77_RS03450	COG2205	protein histidine kinase activity
I3K77_RS03455	COG0745	RESPONSE REGULATOR receiver
I3K77_RS03465	COG1329	Transcriptional regulator
I3K77_RS03480	COG1121	(ABC) transporter
I3K77_RS03485	COG0803	Belongs to the bacterial solute-binding protein 9 family
I3K77_RS03495	COG0539	negative regulation of cytoplasmic translation
I3K77_RS03515	COG0469	pyruvate kinase activity
I3K77_RS03520	COG0494	nUDIX hydrolase
I3K77_RS03540	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I3K77_RS03545	COG1051	belongs to the nudix hydrolase family
I3K77_RS03565	COG0519	Catalyzes the synthesis of GMP from XMP
I3K77_RS03575	COG3250	beta-galactosidase activity
I3K77_RS03610	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I3K77_RS03615	COG0280	phosphate acetyltransferase
I3K77_RS03615	COG0857	belongs to the CobB CobQ family
I3K77_RS03630	COG0406	alpha-ribazole phosphatase activity
I3K77_RS03635	COG0799	negative regulation of ribosome biogenesis
I3K77_RS03655	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I3K77_RS03655	COG2755	lipolytic protein G-D-S-L family
I3K77_RS03720	COG2011	ABC-type metal ion transport system permease component
I3K77_RS03725	COG1473	amidohydrolase
I3K77_RS03740	COG1882	Formate acetyltransferase
I3K77_RS03745	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I3K77_RS03805	COG1611	Belongs to the LOG family
I3K77_RS03825	COG1053	succinate dehydrogenase
I3K77_RS03830	COG0758	DNA mediated transformation
I3K77_RS03850	COG2873	o-acetylhomoserine
I3K77_RS03855	COG1136	(ABC) transporter
I3K77_RS03860	COG0577	efflux transmembrane transporter activity
I3K77_RS03860	COG1136	(ABC) transporter
I3K77_RS03865	COG2197	response regulator
I3K77_RS03870	COG4585	Histidine kinase
I3K77_RS03880	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I3K77_RS03885	COG0012	GTP binding
I3K77_RS03890	COG4974	Belongs to the 'phage' integrase family
I3K77_RS03940	COG2814	Major facilitator Superfamily
I3K77_RS03955	COG2239	Acts as a magnesium transporter
I3K77_RS03965	COG0515	serine threonine protein kinase
I3K77_RS03965	COG2815	serine threonine protein kinase
I3K77_RS04000	COG2233	PERMEase
I3K77_RS04005	COG0513	Belongs to the DEAD box helicase family
I3K77_RS04010	COG1309	transcriptional regulator
I3K77_RS04020	COG1966	Carbon starvation protein
I3K77_RS04030	COG0306	phosphate transporter
I3K77_RS04040	COG2197	response regulator
I3K77_RS04045	COG4585	Histidine kinase
I3K77_RS04050	COG1131	(ABC) transporter
I3K77_RS04095	COG3655	Transcriptional regulator
I3K77_RS04125	COG1136	(ABC) transporter
I3K77_RS04125	COG0577	efflux transmembrane transporter activity
I3K77_RS04135	COG2755	lipolytic protein G-D-S-L family
I3K77_RS04135	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I3K77_RS04140	COG0588	phosphoglycerate mutase activity
I3K77_RS04185	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I3K77_RS04205	COG0719	Fe-S assembly protein
I3K77_RS04210	COG0396	ATPase activity
I3K77_RS04215	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I3K77_RS04225	COG2151	metal-sulfur cluster biosynthetic enzyme
I3K77_RS04245	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I3K77_RS04250	COG0537	adenosine 5'-monophosphoramidase activity
I3K77_RS04255	COG1702	phosphate starvation-inducible protein PhoH
I3K77_RS04280	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
I3K77_RS04305	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I3K77_RS04315	COG2860	membrane
I3K77_RS04340	COG1929	Belongs to the glycerate kinase type-1 family
I3K77_RS04355	COG1609	Transcriptional regulator
I3K77_RS04370	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I3K77_RS04375	COG1609	Transcriptional regulator
I3K77_RS04380	COG0070	glutamate synthase
I3K77_RS04380	COG0069	glutamate synthase activity
I3K77_RS04380	COG0067	glutamate synthase
I3K77_RS04390	COG4166	transmembrane transport
I3K77_RS04405	COG0297	glycogen (starch) synthase activity
I3K77_RS04410	COG1119	ATPase activity
I3K77_RS04415	COG0561	phosphatase activity
I3K77_RS04420	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I3K77_RS04485	COG4221	oxidoreductase activity
I3K77_RS04515	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
I3K77_RS04520	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
I3K77_RS04530	COG3942	CHAP domain
I3K77_RS04530	COG1388	LysM domain
I3K77_RS04550	COG1063	alcohol dehydrogenase
I3K77_RS04560	COG4989	oxidoreductase activity
I3K77_RS04575	COG0588	phosphoglycerate mutase activity
I3K77_RS04585	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I3K77_RS04610	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I3K77_RS04615	COG0284	orotidine-5'-phosphate decarboxylase activity
I3K77_RS04620	COG0543	2 iron, 2 sulfur cluster binding
I3K77_RS04625	COG0167	dihydroorotate dehydrogenase activity
I3K77_RS04645	COG0583	DNA-binding transcription factor activity
I3K77_RS04670	COG3189	MarR family transcriptional regulator
I3K77_RS04695	COG1122	ATPase activity
I3K77_RS04715	COG0681	Belongs to the peptidase S26 family
I3K77_RS04725	COG0833	amino acid
I3K77_RS04750	COG1051	belongs to the nudix hydrolase family
I3K77_RS04825	COG0133	tryptophan synthase activity
I3K77_RS04840	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I3K77_RS04855	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I3K77_RS04875	COG1716	ATPase activity
I3K77_RS04935	COG1187	pseudouridine synthase activity
I3K77_RS04940	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I3K77_RS04965	COG0045	succinate-CoA ligase (ADP-forming) activity
I3K77_RS05065	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I3K77_RS05080	COG0436	Aminotransferase
I3K77_RS05095	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I3K77_RS05120	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I3K77_RS05170	COG1129	ABC transporter
I3K77_RS05185	COG4221	oxidoreductase activity
I3K77_RS05190	COG0488	(ABC) transporter
I3K77_RS05215	COG0693	protein deglycase activity
I3K77_RS05225	COG0575	Belongs to the CDS family
I3K77_RS05265	COG0516	GMP reductase activity
I3K77_RS05335	COG1192	Involved in chromosome partitioning
I3K77_RS05485	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I3K77_RS05485	COG0551	DNA topoisomerase type I activity
I3K77_RS05505	COG3942	CHAP domain
I3K77_RS05570	COG0456	acetyltransferase
I3K77_RS05580	COG0802	atpase or kinase
I3K77_RS05590	COG1228	amidohydrolase
I3K77_RS05600	COG1555	photosystem II stabilization
I3K77_RS05600	COG1596	polysaccharide export
I3K77_RS05610	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I3K77_RS05615	COG0598	Magnesium transport protein CorA
I3K77_RS05620	COG0406	alpha-ribazole phosphatase activity
I3K77_RS05655	COG2801	Transposase and inactivated derivatives
I3K77_RS05660	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I3K77_RS05685	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I3K77_RS05695	COG1201	RNA secondary structure unwinding
I3K77_RS05700	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I3K77_RS05710	COG0187	DNA topoisomerase II activity
I3K77_RS05715	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I3K77_RS05725	COG0142	geranyltranstransferase activity
I3K77_RS05745	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I3K77_RS05760	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I3K77_RS05785	COG1396	sequence-specific DNA binding
I3K77_RS05790	COG1058	Belongs to the CinA family
I3K77_RS05790	COG1546	Belongs to the CinA family
I3K77_RS05820	COG2357	RelA SpoT domain protein
I3K77_RS05830	COG0670	Belongs to the BI1 family
I3K77_RS05845	COG2197	response regulator
I3K77_RS05900	COG0708	Exodeoxyribonuclease III
I3K77_RS05910	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I3K77_RS05915	COG0601	transmembrane transport
I3K77_RS05920	COG4166	transmembrane transport
I3K77_RS05935	COG0287	Prephenate dehydrogenase
I3K77_RS05940	COG1605	Chorismate mutase
I3K77_RS05940	COG0077	Prephenate dehydratase
I3K77_RS05950	COG1217	gtp-binding protein TYPA
I3K77_RS05955	COG0477	Major facilitator Superfamily
I3K77_RS05960	COG1104	cysteine desulfurase activity
I3K77_RS05970	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I3K77_RS05975	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I3K77_RS05985	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I3K77_RS05990	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I3K77_RS06000	COG0577	efflux transmembrane transporter activity
I3K77_RS06000	COG1136	(ABC) transporter
I3K77_RS06020	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I3K77_RS06040	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I3K77_RS06050	COG2017	converts alpha-aldose to the beta-anomer
I3K77_RS06055	COG2017	converts alpha-aldose to the beta-anomer
I3K77_RS06065	COG1595	DNA-templated transcription, initiation
I3K77_RS06080	COG1196	nuclear chromosome segregation
I3K77_RS06085	COG0285	dihydrofolate synthase activity
I3K77_RS06095	COG0006	proline dipeptidase activity
I3K77_RS06115	COG0601	transmembrane transport
I3K77_RS06120	COG4166	transmembrane transport
I3K77_RS06140	COG1940	carbohydrate kinase activity
I3K77_RS06185	COG1472	Belongs to the glycosyl hydrolase 3 family
I3K77_RS06195	COG0395	ABC-type sugar transport system, permease component
I3K77_RS06200	COG1175	transmembrane transport
I3K77_RS06230	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
I3K77_RS06270	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I3K77_RS06280	COG0768	penicillin binding
I3K77_RS06305	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I3K77_RS06335	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I3K77_RS06340	COG2813	Specifically methylates the guanine in position
I3K77_RS06345	COG1643	Atp-dependent helicase
I3K77_RS06360	COG0174	glutamine synthetase
I3K77_RS06410	COG0656	L-ascorbic acid biosynthetic process
I3K77_RS06440	COG4716	Myosin-crossreactive antigen
I3K77_RS06450	COG0587	DNA-directed DNA polymerase activity
I3K77_RS06490	COG1074	ATP-dependent DNA helicase activity
I3K77_RS06495	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
I3K77_RS06525	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I3K77_RS06530	COG1136	(ABC) transporter
I3K77_RS06560	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I3K77_RS06590	COG0352	thiamine-phosphate diphosphorylase activity
I3K77_RS06590	COG0351	phosphomethylpyrimidine kinase
I3K77_RS06600	COG2271	Major facilitator Superfamily
I3K77_RS06630	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I3K77_RS06640	COG1957	nucleoside hydrolase
I3K77_RS06685	COG3480	Lon protease (S16) C-terminal proteolytic domain
I3K77_RS06720	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I3K77_RS06740	COG2873	o-acetylhomoserine
I3K77_RS06765	COG0626	cystathionine gamma-synthase activity
I3K77_RS06770	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I3K77_RS06775	COG1126	abc transporter atp-binding protein
I3K77_RS06780	COG0765	amino acid transport
I3K77_RS06795	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I3K77_RS06810	COG0284	orotidine-5'-phosphate decarboxylase activity
I3K77_RS06835	COG0577	efflux transmembrane transporter activity
I3K77_RS06835	COG1136	(ABC) transporter
I3K77_RS06840	COG0390	transport system, permease component
I3K77_RS06845	COG1376	ErfK ybiS ycfS ynhG family protein
I3K77_RS06855	COG4106	trans-aconitate 2-methyltransferase activity
I3K77_RS06870	COG1250	3-hydroxyacyl-CoA dehydrogenase
I3K77_RS06875	COG1501	Belongs to the glycosyl hydrolase 31 family
I3K77_RS06890	COG0395	ABC-type sugar transport system, permease component
I3K77_RS06905	COG2826	transposase and inactivated derivatives, IS30 family
I3K77_RS06930	COG1122	ATPase activity
I3K77_RS06985	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I3K77_RS06990	COG2814	Major facilitator Superfamily
I3K77_RS07025	COG0745	RESPONSE REGULATOR receiver
I3K77_RS07035	COG4581	dead DEAH box helicase
I3K77_RS07040	COG2326	polyphosphate kinase activity
I3K77_RS07060	COG0765	amino acid transport
I3K77_RS07065	COG0765	amino acid transport
I3K77_RS07070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I3K77_RS07075	COG1126	abc transporter atp-binding protein
I3K77_RS07095	COG1196	nuclear chromosome segregation
I3K77_RS07120	COG0402	S-adenosylhomocysteine deaminase activity
I3K77_RS07130	COG0589	response to stress
I3K77_RS07140	COG1278	Cold shock
I3K77_RS07145	COG2205	protein histidine kinase activity
I3K77_RS07150	COG0745	RESPONSE REGULATOR receiver
I3K77_RS07170	COG1278	Cold shock
I3K77_RS07185	COG0714	Associated with various cellular activities
I3K77_RS07235	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I3K77_RS07265	COG4122	O-methyltransferase activity
I3K77_RS07275	COG0586	Pfam SNARE associated Golgi protein
I3K77_RS07280	COG0560	Phosphoserine phosphatase
I3K77_RS07285	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I3K77_RS07365	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I3K77_RS07375	COG1609	Transcriptional regulator
I3K77_RS07385	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I3K77_RS07390	COG1979	alcohol dehydrogenase
I3K77_RS07395	COG0546	phosphoglycolate phosphatase activity
I3K77_RS07405	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I3K77_RS07410	COG0135	phosphoribosylanthranilate isomerase activity
I3K77_RS07415	COG1122	ATPase activity
I3K77_RS07440	COG1132	(ABC) transporter
I3K77_RS07445	COG1132	(ABC) transporter
I3K77_RS07455	COG1472	Belongs to the glycosyl hydrolase 3 family
I3K77_RS07485	COG1609	Transcriptional regulator
I3K77_RS07495	COG0154	amidase activity
I3K77_RS07505	COG2182	Extracellular solute-binding protein
I3K77_RS07545	COG1309	transcriptional regulator
I3K77_RS07560	COG0602	queuosine metabolic process
I3K77_RS07565	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I3K77_RS07565	COG1328	CTP reductase activity
I3K77_RS07570	COG1570	exodeoxyribonuclease VII activity
I3K77_RS07575	COG1722	exodeoxyribonuclease VII activity
I3K77_RS07580	COG2249	NAD(P)H dehydrogenase (quinone) activity
I3K77_RS07585	COG1022	Amp-dependent synthetase and ligase
I3K77_RS07590	COG1970	mechanosensitive ion channel activity
I3K77_RS07615	COG0248	Ppx GppA phosphatase
I3K77_RS07620	COG0436	Aminotransferase
I3K77_RS07680	COG3590	peptidase
I3K77_RS07705	COG1355	regulation of microtubule-based process
I3K77_RS07710	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I3K77_RS07725	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I3K77_RS07730	COG0009	L-threonylcarbamoyladenylate synthase
I3K77_RS07735	COG0110	maltose O-acetyltransferase activity
I3K77_RS07790	COG1070	Carbohydrate kinase
I3K77_RS07820	COG3507	Belongs to the glycosyl hydrolase 43 family
I3K77_RS07825	COG3507	Belongs to the glycosyl hydrolase 43 family
I3K77_RS07830	COG0395	ABC-type sugar transport system, permease component
I3K77_RS07835	COG1175	transmembrane transport
I3K77_RS07845	COG1609	Transcriptional regulator
I3K77_RS07850	COG1979	alcohol dehydrogenase
I3K77_RS07860	COG2814	Major facilitator Superfamily
I3K77_RS07865	COG2814	Major facilitator Superfamily
I3K77_RS07875	COG0242	peptide deformylase activity
I3K77_RS07885	COG2814	Major facilitator Superfamily
I3K77_RS07900	COG4214	carbohydrate transport
I3K77_RS07920	COG1129	ABC transporter
I3K77_RS07925	COG1940	carbohydrate kinase activity
I3K77_RS07940	COG1946	Acyl-CoA thioesterase
I3K77_RS07950	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I3K77_RS07955	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I3K77_RS07965	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I3K77_RS07970	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
I3K77_RS08010	COG1454	alcohol dehydrogenase
I3K77_RS08015	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I3K77_RS08030	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I3K77_RS08045	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I3K77_RS08050	COG1687	branched-chain amino acid
I3K77_RS08055	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I3K77_RS08075	COG0589	response to stress
I3K77_RS08080	COG0791	NLP P60 protein
I3K77_RS08090	COG1705	Flagellar rod assembly protein muramidase FlgJ
I3K77_RS08090	COG3942	CHAP domain
I3K77_RS08095	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I3K77_RS08105	COG5002	protein histidine kinase activity
I3K77_RS08110	COG0704	Plays a role in the regulation of phosphate uptake
I3K77_RS08120	COG1575	Belongs to the MenA family. Type 1 subfamily
I3K77_RS08125	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I3K77_RS08135	COG2814	Major facilitator Superfamily
I3K77_RS08170	COG2197	response regulator
I3K77_RS08195	COG0395	ABC-type sugar transport system, permease component
I3K77_RS08200	COG1175	transmembrane transport
I3K77_RS08225	COG1803	Methylglyoxal synthase
I3K77_RS08225	COG1597	lipid kinase activity
I3K77_RS08230	COG3711	transcriptional antiterminator
I3K77_RS08260	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I3K77_RS08270	COG0328	RNA-DNA hybrid ribonuclease activity
I3K77_RS08295	COG0196	riboflavin kinase activity
I3K77_RS08330	COG3534	alpha-L-arabinofuranosidase
I3K77_RS08345	COG2308	Evidence 4 Homologs of previously reported genes of
I3K77_RS08450	COG0255	Belongs to the universal ribosomal protein uL29 family
I3K77_RS08505	COG1012	belongs to the aldehyde dehydrogenase family
I3K77_RS08505	COG1454	alcohol dehydrogenase
I3K77_RS08520	COG1063	alcohol dehydrogenase
I3K77_RS08540	COG1063	alcohol dehydrogenase
I3K77_RS08570	COG1739	Uncharacterized protein family UPF0029
I3K77_RS08575	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I3K77_RS08595	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I3K77_RS08610	COG0531	amino acid
I3K77_RS08615	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I3K77_RS08705	COG2252	PERMEase
I3K77_RS08725	COG3507	Belongs to the glycosyl hydrolase 43 family
I3K77_RS08730	COG3507	Belongs to the glycosyl hydrolase 43 family
I3K77_RS08785	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I3K77_RS08790	COG4770	biotin carboxylase activity
I3K77_RS08795	COG1268	BioY protein
I3K77_RS08850	COG0250	Participates in transcription elongation, termination and antitermination
I3K77_RS08855	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I3K77_RS08865	COG0436	Aminotransferase
I3K77_RS08890	COG1530	ribonuclease E activity
I3K77_RS08895	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I3K77_RS08925	COG0083	homoserine kinase activity
I3K77_RS08930	COG0460	homoserine dehydrogenase
I3K77_RS08945	COG1309	transcriptional regulator
I3K77_RS08965	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I3K77_RS08970	COG0446	pyridine nucleotide-disulphide oxidoreductase
I3K77_RS09000	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I3K77_RS09005	COG0406	alpha-ribazole phosphatase activity
I3K77_RS09005	COG0494	nUDIX hydrolase
I3K77_RS09030	COG0584	glycerophosphoryl diester phosphodiesterase
I3K77_RS09045	COG2986	histidine ammonia-lyase
I3K77_RS09060	COG0179	Fumarylacetoacetate (FAA) hydrolase
I3K77_RS09080	COG1088	dTDP-glucose 4,6-dehydratase activity
I3K77_RS09095	COG1216	Glycosyl transferase, family 2
I3K77_RS09120	COG1216	Glycosyl transferase, family 2
I3K77_RS09215	COG2247	cell wall binding repeat
I3K77_RS09215	COG0860	N-Acetylmuramoyl-L-alanine amidase
I3K77_RS09225	COG0463	Glycosyl transferase, family 2
I3K77_RS09255	COG1129	ABC transporter
I3K77_RS09275	COG0084	hydrolase, TatD family'
I3K77_RS09285	COG1132	(ABC) transporter
I3K77_RS09290	COG1132	(ABC) transporter
I3K77_RS09300	COG1609	Transcriptional regulator
I3K77_RS09355	COG1132	(ABC) transporter
I3K77_RS09365	COG1846	Transcriptional regulator
I3K77_RS09390	COG1113	amino acid transport
I3K77_RS09400	COG1136	(ABC) transporter
I3K77_RS09400	COG0577	efflux transmembrane transporter activity
I3K77_RS09410	COG1113	amino acid transport
I3K77_RS09445	COG1609	Transcriptional regulator
I3K77_RS09455	COG0588	phosphoglycerate mutase activity
I3K77_RS09465	COG0778	Nitroreductase
I3K77_RS09515	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I3K77_RS09520	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I3K77_RS09525	COG0366	Alpha amylase catalytic
I3K77_RS09535	COG0395	ABC-type sugar transport system, permease component
I3K77_RS09540	COG1175	transmembrane transport
I3K77_RS09560	COG0037	tRNA processing
I3K77_RS09560	COG0590	tRNA wobble adenosine to inosine editing
I3K77_RS09565	COG0025	NhaP-type Na H and K H
I3K77_RS09590	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I3K77_RS09605	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I3K77_RS09640	COG3842	ATPase activity
I3K77_RS09645	COG1215	transferase activity, transferring glycosyl groups
I3K77_RS09655	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I3K77_RS09680	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I3K77_RS09705	COG3583	domain protein
I3K77_RS09725	COG0617	tRNA 3'-terminal CCA addition
I3K77_RS09750	COG1475	DNA binding
I3K77_RS09755	COG1192	Involved in chromosome partitioning
I3K77_RS10100	COG3764	Sortase (surface protein transpeptidase)
I3K77_RS10120	COG3942	CHAP domain
I3K77_RS10120	COG1388	LysM domain
I3K77_RS10155	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
I3K77_RS10160	COG1396	sequence-specific DNA binding
I3K77_RS10205	COG1002	Type II restriction enzyme, methylase subunits
I3K77_RS10290	COG3550	peptidyl-serine autophosphorylation
I3K77_RS10325	COG0675	Transposase, IS605 OrfB family
I3K77_RS10390	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I3K77_RS10400	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I3K77_RS10680	COG1397	ADP-ribosylglycohydrolase
I3K77_RS10715	COG0305	Participates in initiation and elongation during chromosome replication
I3K77_RS10800	COG1192	Involved in chromosome partitioning
I3K77_RS10995	COG3655	Transcriptional regulator
I3K77_RS11000	COG1316	TRANSCRIPTIONal
I3K77_RS11035	COG4974	Belongs to the 'phage' integrase family