locus-tag	class	description
H4O80_RS00010	COG0592	DNA-directed DNA polymerase activity
H4O80_RS00025	COG0187	DNA topoisomerase II activity
H4O80_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H4O80_RS00035	COG3266	domain, Protein
H4O80_RS00045	COG4677	pectinesterase activity
H4O80_RS00050	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H4O80_RS00055	COG1522	sequence-specific DNA binding
H4O80_RS00060	COG0436	Aminotransferase
H4O80_RS00095	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H4O80_RS00100	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H4O80_RS00110	COG3265	gluconokinase activity
H4O80_RS00120	COG0783	Belongs to the Dps family
H4O80_RS00125	COG1253	flavin adenine dinucleotide binding
H4O80_RS00175	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
H4O80_RS00185	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H4O80_RS00200	COG0180	Tryptophanyl-tRNA synthetase
H4O80_RS00215	COG0058	SHG alpha-glucan phosphorylase activity
H4O80_RS00255	COG0515	serine threonine protein kinase
H4O80_RS00260	COG0768	penicillin binding
H4O80_RS00320	COG0071	Belongs to the small heat shock protein (HSP20) family
H4O80_RS00340	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
H4O80_RS00400	COG0343	queuine tRNA-ribosyltransferase activity
H4O80_RS00420	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H4O80_RS00425	COG0805	protein transport
H4O80_RS00465	COG0191	fructose-bisphosphate aldolase activity
H4O80_RS00500	COG3534	alpha-L-arabinofuranosidase
H4O80_RS00520	COG4974	Belongs to the 'phage' integrase family
H4O80_RS00555	COG0477	Major facilitator Superfamily
H4O80_RS00570	COG0366	Alpha amylase catalytic
H4O80_RS00595	COG1609	Transcriptional regulator
H4O80_RS00600	COG0395	ABC-type sugar transport system, permease component
H4O80_RS00625	COG0789	Transcriptional regulator
H4O80_RS00645	COG1028	Short-chain dehydrogenase reductase Sdr
H4O80_RS00650	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H4O80_RS00655	COG1175	transmembrane transport
H4O80_RS00660	COG0395	ABC-type sugar transport system, permease component
H4O80_RS00675	COG1609	Transcriptional regulator
H4O80_RS00680	COG0586	Pfam SNARE associated Golgi protein
H4O80_RS00745	COG3547	Transposase (IS116 IS110 IS902 family)
H4O80_RS00765	COG0527	aspartate kinase activity
H4O80_RS00790	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H4O80_RS00805	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H4O80_RS00805	COG1754	DNA topoisomerase type I activity
H4O80_RS00860	COG0676	glucose-6-phosphate 1-epimerase activity
H4O80_RS00890	COG0366	Alpha amylase catalytic
H4O80_RS00895	COG3619	membrane
H4O80_RS00910	COG0672	)-iron permease
H4O80_RS00915	COG3470	protein probably involved in high-affinity Fe2 transport
H4O80_RS00930	COG0577	efflux transmembrane transporter activity
H4O80_RS00935	COG1136	(ABC) transporter
H4O80_RS00965	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
H4O80_RS00970	COG0363	glucosamine-6-phosphate deaminase activity
H4O80_RS00995	COG1215	transferase activity, transferring glycosyl groups
H4O80_RS01000	COG1309	transcriptional regulator
H4O80_RS01020	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
H4O80_RS01030	COG0305	Participates in initiation and elongation during chromosome replication
H4O80_RS01035	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H4O80_RS01040	COG3442	glutamine amidotransferase
H4O80_RS01055	COG1609	Transcriptional regulator
H4O80_RS01065	COG1175	transmembrane transport
H4O80_RS01070	COG0395	ABC-type sugar transport system, permease component
H4O80_RS01090	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
H4O80_RS01130	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H4O80_RS01135	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H4O80_RS01140	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H4O80_RS01150	COG1937	Protein conserved in bacteria
H4O80_RS01155	COG1322	Protein conserved in bacteria
H4O80_RS01165	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H4O80_RS01210	COG1605	Chorismate mutase
H4O80_RS01210	COG0287	Prephenate dehydrogenase
H4O80_RS01235	COG0745	RESPONSE REGULATOR receiver
H4O80_RS01250	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H4O80_RS01280	COG0356	it plays a direct role in the translocation of protons across the membrane
H4O80_RS01315	COG0355	proton-transporting ATP synthase activity, rotational mechanism
H4O80_RS01325	COG0545	Peptidyl-prolyl cis-trans isomerase
H4O80_RS01355	COG0251	oxidation-reduction process
H4O80_RS01390	COG3842	ATPase activity
H4O80_RS01405	COG1027	Aspartate ammonia-lyase
H4O80_RS01420	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H4O80_RS01445	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
H4O80_RS01445	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
H4O80_RS01460	COG0742	ribosomal rna small subunit methyltransferase
H4O80_RS01470	COG0826	peptidase U32
H4O80_RS01475	COG1496	oxidoreductase activity
H4O80_RS01485	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
H4O80_RS01495	COG3579	cysteine-type endopeptidase activity
H4O80_RS01500	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H4O80_RS01505	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H4O80_RS01510	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H4O80_RS01515	COG5002	protein histidine kinase activity
H4O80_RS01520	COG0745	RESPONSE REGULATOR receiver
H4O80_RS01545	COG1704	LemA family
H4O80_RS01560	COG1957	nucleoside hydrolase
H4O80_RS01570	COG1837	Belongs to the UPF0109 family
H4O80_RS01600	COG0505	Belongs to the CarA family
H4O80_RS01605	COG0488	(ABC) transporter
H4O80_RS01620	COG0440	acetolactate synthase activity
H4O80_RS01660	COG0667	Aldo Keto reductase
H4O80_RS01700	COG2826	transposase and inactivated derivatives, IS30 family
H4O80_RS01705	COG2348	transferase activity, transferring amino-acyl groups
H4O80_RS01710	COG2348	transferase activity, transferring amino-acyl groups
H4O80_RS01740	COG1116	anion transmembrane transporter activity
H4O80_RS01760	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H4O80_RS01765	COG1609	Transcriptional regulator
H4O80_RS01785	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
H4O80_RS01795	COG0577	efflux transmembrane transporter activity
H4O80_RS01820	COG1132	(ABC) transporter
H4O80_RS01825	COG2814	Major facilitator Superfamily
H4O80_RS01860	COG0656	L-ascorbic acid biosynthetic process
H4O80_RS01880	COG2814	Major facilitator Superfamily
H4O80_RS01885	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H4O80_RS01895	COG0489	protein tyrosine kinase activity
H4O80_RS01910	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
H4O80_RS01915	COG1028	Short-chain dehydrogenase reductase Sdr
H4O80_RS01925	COG0438	transferase activity, transferring glycosyl groups
H4O80_RS01965	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H4O80_RS01990	COG3118	belongs to the thioredoxin family
H4O80_RS01990	COG0492	ferredoxin-NADP+ reductase activity
H4O80_RS02030	COG0095	Lipoate-protein ligase
H4O80_RS02040	COG4499	WXG100 protein secretion system (Wss), protein YukC
H4O80_RS02040	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H4O80_RS02045	COG1902	pentaerythritol trinitrate reductase activity
H4O80_RS02050	COG0167	dihydroorotate dehydrogenase activity
H4O80_RS02055	COG1349	DNA-binding transcription factor activity
H4O80_RS02065	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
H4O80_RS02080	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H4O80_RS02130	COG0714	Associated with various cellular activities
H4O80_RS02170	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
H4O80_RS02210	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
H4O80_RS02215	COG2884	Cell division ATP-binding protein ftsE
H4O80_RS02220	COG2177	Part of the ABC transporter FtsEX involved in
H4O80_RS02225	COG3942	CHAP domain
H4O80_RS02225	COG1388	LysM domain
H4O80_RS02260	COG0564	pseudouridine synthase activity
H4O80_RS02275	COG1175	transmembrane transport
H4O80_RS02280	COG0395	ABC-type sugar transport system, permease component
H4O80_RS02290	COG1609	Transcriptional regulator
H4O80_RS02295	COG3534	alpha-L-arabinofuranosidase
H4O80_RS02300	COG1653	transport
H4O80_RS02305	COG1653	transport
H4O80_RS02320	COG0747	negative chemotaxis
H4O80_RS02325	COG0601	transmembrane transport
H4O80_RS02330	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H4O80_RS02340	COG4608	Belongs to the ABC transporter superfamily
H4O80_RS02350	COG0626	cystathionine gamma-synthase activity
H4O80_RS02360	COG0514	ATP-dependent DNA helicase (RecQ)
H4O80_RS02375	COG0531	amino acid
H4O80_RS02380	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H4O80_RS02390	COG0358	DNA primase activity
H4O80_RS02395	COG2826	transposase and inactivated derivatives, IS30 family
H4O80_RS02405	COG3655	Transcriptional regulator
H4O80_RS02420	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H4O80_RS02430	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
H4O80_RS02445	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H4O80_RS02460	COG0577	efflux transmembrane transporter activity
H4O80_RS02460	COG1136	(ABC) transporter
H4O80_RS02470	COG0577	efflux transmembrane transporter activity
H4O80_RS02470	COG1136	(ABC) transporter
H4O80_RS02475	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H4O80_RS02485	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
H4O80_RS02490	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H4O80_RS02515	COG1012	belongs to the aldehyde dehydrogenase family
H4O80_RS02545	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H4O80_RS02555	COG0402	S-adenosylhomocysteine deaminase activity
H4O80_RS02560	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
H4O80_RS02565	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H4O80_RS02575	COG0667	Aldo Keto reductase
H4O80_RS02605	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H4O80_RS02635	COG0385	Bile acid
H4O80_RS02665	COG0583	DNA-binding transcription factor activity
H4O80_RS02690	COG1063	alcohol dehydrogenase
H4O80_RS02730	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H4O80_RS02750	COG3250	beta-galactosidase activity
H4O80_RS02775	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H4O80_RS02780	COG4721	ABC-type cobalt transport system, permease component
H4O80_RS02785	COG1122	ATPase activity
H4O80_RS02795	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H4O80_RS02870	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H4O80_RS02875	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H4O80_RS02920	COG0569	domain protein
H4O80_RS02925	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H4O80_RS02935	COG0497	DNA recombination
H4O80_RS02940	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H4O80_RS02950	COG1131	(ABC) transporter
H4O80_RS02965	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
H4O80_RS02990	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
H4O80_RS03005	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H4O80_RS03005	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H4O80_RS03020	COG0667	Aldo Keto reductase
H4O80_RS03055	COG1760	l-serine dehydratase
H4O80_RS03065	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H4O80_RS03095	COG1316	TRANSCRIPTIONal
H4O80_RS03130	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H4O80_RS03140	COG2205	protein histidine kinase activity
H4O80_RS03145	COG0745	RESPONSE REGULATOR receiver
H4O80_RS03155	COG1329	Transcriptional regulator
H4O80_RS03170	COG1121	(ABC) transporter
H4O80_RS03175	COG0803	Belongs to the bacterial solute-binding protein 9 family
H4O80_RS03185	COG0539	negative regulation of cytoplasmic translation
H4O80_RS03205	COG0469	pyruvate kinase activity
H4O80_RS03210	COG0494	nUDIX hydrolase
H4O80_RS03230	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
H4O80_RS03235	COG1051	belongs to the nudix hydrolase family
H4O80_RS03385	COG2826	transposase and inactivated derivatives, IS30 family
H4O80_RS03480	COG1475	DNA binding
H4O80_RS03545	COG3177	Filamentation induced by cAMP protein fic
H4O80_RS03570	COG3250	beta-galactosidase activity
H4O80_RS03610	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H4O80_RS03615	COG0857	belongs to the CobB CobQ family
H4O80_RS03615	COG0280	phosphate acetyltransferase
H4O80_RS03630	COG0406	alpha-ribazole phosphatase activity
H4O80_RS03635	COG0799	negative regulation of ribosome biogenesis
H4O80_RS03655	COG2755	lipolytic protein G-D-S-L family
H4O80_RS03655	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
H4O80_RS03730	COG2011	ABC-type metal ion transport system permease component
H4O80_RS03735	COG1473	amidohydrolase
H4O80_RS03750	COG1882	Formate acetyltransferase
H4O80_RS03755	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
H4O80_RS03815	COG1611	Belongs to the LOG family
H4O80_RS03830	COG1053	succinate dehydrogenase
H4O80_RS03835	COG0758	DNA mediated transformation
H4O80_RS03855	COG2873	o-acetylhomoserine
H4O80_RS03860	COG1136	(ABC) transporter
H4O80_RS03865	COG1136	(ABC) transporter
H4O80_RS03865	COG0577	efflux transmembrane transporter activity
H4O80_RS03870	COG2197	response regulator
H4O80_RS03885	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H4O80_RS03890	COG0012	GTP binding
H4O80_RS03960	COG2814	Major facilitator Superfamily
H4O80_RS03970	COG0515	serine threonine protein kinase
H4O80_RS03970	COG2815	serine threonine protein kinase
H4O80_RS04010	COG2233	PERMEase
H4O80_RS04015	COG0513	Belongs to the DEAD box helicase family
H4O80_RS04020	COG2826	transposase and inactivated derivatives, IS30 family
H4O80_RS04025	COG1309	transcriptional regulator
H4O80_RS04035	COG1966	Carbon starvation protein
H4O80_RS04045	COG0306	phosphate transporter
H4O80_RS04055	COG2197	response regulator
H4O80_RS04060	COG4585	Histidine kinase
H4O80_RS04065	COG1131	(ABC) transporter
H4O80_RS04110	COG3655	Transcriptional regulator
H4O80_RS04140	COG1136	(ABC) transporter
H4O80_RS04140	COG0577	efflux transmembrane transporter activity
H4O80_RS04150	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
H4O80_RS04150	COG2755	lipolytic protein G-D-S-L family
H4O80_RS04155	COG0588	phosphoglycerate mutase activity
H4O80_RS04200	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
H4O80_RS04225	COG0719	Fe-S assembly protein
H4O80_RS04230	COG0396	ATPase activity
H4O80_RS04235	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H4O80_RS04245	COG2151	metal-sulfur cluster biosynthetic enzyme
H4O80_RS04265	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H4O80_RS04270	COG0537	adenosine 5'-monophosphoramidase activity
H4O80_RS04275	COG1702	phosphate starvation-inducible protein PhoH
H4O80_RS04300	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
H4O80_RS04325	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H4O80_RS04335	COG2860	membrane
H4O80_RS04360	COG1929	Belongs to the glycerate kinase type-1 family
H4O80_RS04375	COG1609	Transcriptional regulator
H4O80_RS04390	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
H4O80_RS04400	COG0070	glutamate synthase
H4O80_RS04400	COG0067	glutamate synthase
H4O80_RS04400	COG0069	glutamate synthase activity
H4O80_RS04410	COG4166	transmembrane transport
H4O80_RS04425	COG0297	glycogen (starch) synthase activity
H4O80_RS04430	COG1119	ATPase activity
H4O80_RS04435	COG0561	phosphatase activity
H4O80_RS04440	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H4O80_RS04555	COG4989	oxidoreductase activity
H4O80_RS04585	COG0588	phosphoglycerate mutase activity
H4O80_RS04595	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
H4O80_RS04620	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H4O80_RS04625	COG0284	orotidine-5'-phosphate decarboxylase activity
H4O80_RS04630	COG0543	2 iron, 2 sulfur cluster binding
H4O80_RS04635	COG0167	dihydroorotate dehydrogenase activity
H4O80_RS04655	COG0583	DNA-binding transcription factor activity
H4O80_RS04690	COG0681	Belongs to the peptidase S26 family
H4O80_RS04695	COG0833	amino acid
H4O80_RS04710	COG0706	membrane insertase activity
H4O80_RS04715	COG0706	membrane insertase activity
H4O80_RS04720	COG1051	belongs to the nudix hydrolase family
H4O80_RS04765	COG0577	efflux transmembrane transporter activity
H4O80_RS04765	COG1136	(ABC) transporter
H4O80_RS04775	COG4585	Histidine kinase
H4O80_RS04790	COG1131	(ABC) transporter
H4O80_RS04820	COG1131	(ABC) transporter
H4O80_RS04885	COG0133	tryptophan synthase activity
H4O80_RS04900	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H4O80_RS04935	COG1716	ATPase activity
H4O80_RS04950	COG1803	Methylglyoxal synthase
H4O80_RS05085	COG1187	pseudouridine synthase activity
H4O80_RS05090	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H4O80_RS05115	COG0045	succinate-CoA ligase (ADP-forming) activity
H4O80_RS05215	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H4O80_RS05230	COG0436	Aminotransferase
H4O80_RS05245	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H4O80_RS05270	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H4O80_RS05320	COG1129	ABC transporter
H4O80_RS05335	COG1028	Short-chain dehydrogenase reductase Sdr
H4O80_RS05340	COG0488	(ABC) transporter
H4O80_RS05365	COG0693	protein deglycase activity
H4O80_RS05375	COG0575	Belongs to the CDS family
H4O80_RS05415	COG0516	GMP reductase activity
H4O80_RS05490	COG1192	Involved in chromosome partitioning
H4O80_RS05640	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H4O80_RS05640	COG0551	DNA topoisomerase type I activity
H4O80_RS05660	COG3942	CHAP domain
H4O80_RS05785	COG0456	acetyltransferase
H4O80_RS05795	COG0802	atpase or kinase
H4O80_RS05805	COG1228	amidohydrolase
H4O80_RS05815	COG1555	photosystem II stabilization
H4O80_RS05815	COG1596	polysaccharide export
H4O80_RS05825	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H4O80_RS05830	COG0598	Magnesium transport protein CorA
H4O80_RS05835	COG0406	alpha-ribazole phosphatase activity
H4O80_RS05870	COG2801	Transposase and inactivated derivatives
H4O80_RS05875	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H4O80_RS05900	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H4O80_RS05910	COG1201	RNA secondary structure unwinding
H4O80_RS05915	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H4O80_RS05925	COG0187	DNA topoisomerase II activity
H4O80_RS05930	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H4O80_RS05940	COG0142	geranyltranstransferase activity
H4O80_RS05965	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H4O80_RS05980	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
H4O80_RS06005	COG1396	sequence-specific DNA binding
H4O80_RS06010	COG1058	Belongs to the CinA family
H4O80_RS06010	COG1546	Belongs to the CinA family
H4O80_RS06040	COG2357	RelA SpoT domain protein
H4O80_RS06050	COG0670	Belongs to the BI1 family
H4O80_RS06110	COG0708	Exodeoxyribonuclease III
H4O80_RS06120	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H4O80_RS06125	COG0601	transmembrane transport
H4O80_RS06130	COG4166	transmembrane transport
H4O80_RS06145	COG0287	Prephenate dehydrogenase
H4O80_RS06150	COG0077	Prephenate dehydratase
H4O80_RS06150	COG1605	Chorismate mutase
H4O80_RS06160	COG1217	gtp-binding protein TYPA
H4O80_RS06165	COG0477	Major facilitator Superfamily
H4O80_RS06170	COG1104	cysteine desulfurase activity
H4O80_RS06180	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
H4O80_RS06185	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
H4O80_RS06195	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H4O80_RS06200	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
H4O80_RS06210	COG0577	efflux transmembrane transporter activity
H4O80_RS06210	COG1136	(ABC) transporter
H4O80_RS06230	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
H4O80_RS06255	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H4O80_RS06265	COG2017	converts alpha-aldose to the beta-anomer
H4O80_RS06270	COG2017	converts alpha-aldose to the beta-anomer
H4O80_RS06280	COG1595	DNA-templated transcription, initiation
H4O80_RS06295	COG1196	nuclear chromosome segregation
H4O80_RS06300	COG0285	dihydrofolate synthase activity
H4O80_RS06310	COG2826	transposase and inactivated derivatives, IS30 family
H4O80_RS06315	COG0006	proline dipeptidase activity
H4O80_RS06335	COG0601	transmembrane transport
H4O80_RS06340	COG4166	transmembrane transport
H4O80_RS06360	COG1940	carbohydrate kinase activity
H4O80_RS06380	COG0738	Major facilitator superfamily
H4O80_RS06395	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
H4O80_RS06435	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H4O80_RS06445	COG0768	penicillin binding
H4O80_RS06470	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H4O80_RS06490	COG2826	transposase and inactivated derivatives, IS30 family
H4O80_RS06505	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H4O80_RS06510	COG2813	Specifically methylates the guanine in position
H4O80_RS06515	COG1643	Atp-dependent helicase
H4O80_RS06530	COG0174	glutamine synthetase
H4O80_RS06580	COG0656	L-ascorbic acid biosynthetic process
H4O80_RS06605	COG4716	Myosin-crossreactive antigen
H4O80_RS06615	COG0587	DNA-directed DNA polymerase activity
H4O80_RS06630	COG1373	ATPase (AAA superfamily
H4O80_RS06660	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H4O80_RS06690	COG0351	phosphomethylpyrimidine kinase
H4O80_RS06690	COG0352	thiamine-phosphate diphosphorylase activity
H4O80_RS06700	COG2271	Major facilitator Superfamily
H4O80_RS06735	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H4O80_RS06745	COG1957	nucleoside hydrolase
H4O80_RS06790	COG3480	Lon protease (S16) C-terminal proteolytic domain
H4O80_RS06825	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
H4O80_RS06845	COG2873	o-acetylhomoserine
H4O80_RS06870	COG0626	cystathionine gamma-synthase activity
H4O80_RS06875	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H4O80_RS06880	COG1126	abc transporter atp-binding protein
H4O80_RS06885	COG0765	amino acid transport
H4O80_RS06900	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H4O80_RS06915	COG0284	orotidine-5'-phosphate decarboxylase activity
H4O80_RS06945	COG0390	transport system, permease component
H4O80_RS06965	COG1250	3-hydroxyacyl-CoA dehydrogenase
H4O80_RS06970	COG1501	Belongs to the glycosyl hydrolase 31 family
H4O80_RS06985	COG0395	ABC-type sugar transport system, permease component
H4O80_RS07025	COG1122	ATPase activity
H4O80_RS07080	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H4O80_RS07085	COG2814	Major facilitator Superfamily
H4O80_RS07120	COG0745	RESPONSE REGULATOR receiver
H4O80_RS07130	COG4581	dead DEAH box helicase
H4O80_RS07135	COG2326	polyphosphate kinase activity
H4O80_RS07160	COG0765	amino acid transport
H4O80_RS07165	COG0765	amino acid transport
H4O80_RS07170	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H4O80_RS07175	COG1126	abc transporter atp-binding protein
H4O80_RS07195	COG1196	nuclear chromosome segregation
H4O80_RS07210	COG0477	Major facilitator Superfamily
H4O80_RS07225	COG0402	S-adenosylhomocysteine deaminase activity
H4O80_RS07235	COG0589	response to stress
H4O80_RS07245	COG1278	Cold shock
H4O80_RS07250	COG2205	protein histidine kinase activity
H4O80_RS07255	COG0745	RESPONSE REGULATOR receiver
H4O80_RS07275	COG1278	Cold shock
H4O80_RS07290	COG0714	Associated with various cellular activities
H4O80_RS07340	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H4O80_RS07355	COG1472	Belongs to the glycosyl hydrolase 3 family
H4O80_RS07365	COG3279	Response regulator of the LytR AlgR family
H4O80_RS07395	COG0586	Pfam SNARE associated Golgi protein
H4O80_RS07400	COG0560	Phosphoserine phosphatase
H4O80_RS07405	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H4O80_RS07435	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
H4O80_RS07490	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
H4O80_RS07495	COG3250	beta-galactosidase activity
H4O80_RS07500	COG1609	Transcriptional regulator
H4O80_RS07510	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H4O80_RS07515	COG1979	alcohol dehydrogenase
H4O80_RS07520	COG0546	phosphoglycolate phosphatase activity
H4O80_RS07530	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H4O80_RS07535	COG0135	phosphoribosylanthranilate isomerase activity
H4O80_RS07540	COG1122	ATPase activity
H4O80_RS07565	COG1132	(ABC) transporter
H4O80_RS07570	COG1132	(ABC) transporter
H4O80_RS07625	COG0602	queuosine metabolic process
H4O80_RS07630	COG1328	CTP reductase activity
H4O80_RS07630	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H4O80_RS07640	COG1570	exodeoxyribonuclease VII activity
H4O80_RS07645	COG1722	exodeoxyribonuclease VII activity
H4O80_RS07650	COG2249	NAD(P)H dehydrogenase (quinone) activity
H4O80_RS07655	COG1022	Amp-dependent synthetase and ligase
H4O80_RS07660	COG1970	mechanosensitive ion channel activity
H4O80_RS07685	COG0248	Ppx GppA phosphatase
H4O80_RS07690	COG0436	Aminotransferase
H4O80_RS07745	COG3590	peptidase
H4O80_RS07770	COG1355	regulation of microtubule-based process
H4O80_RS07775	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H4O80_RS07790	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H4O80_RS07795	COG0009	L-threonylcarbamoyladenylate synthase
H4O80_RS07800	COG0110	maltose O-acetyltransferase activity
H4O80_RS07855	COG1070	Carbohydrate kinase
H4O80_RS07885	COG3507	Belongs to the glycosyl hydrolase 43 family
H4O80_RS07910	COG3507	Belongs to the glycosyl hydrolase 43 family
H4O80_RS07915	COG0395	ABC-type sugar transport system, permease component
H4O80_RS07920	COG1175	transmembrane transport
H4O80_RS07930	COG1609	Transcriptional regulator
H4O80_RS07935	COG1979	alcohol dehydrogenase
H4O80_RS07945	COG2814	Major facilitator Superfamily
H4O80_RS07960	COG0242	peptide deformylase activity
H4O80_RS07985	COG4214	carbohydrate transport
H4O80_RS08005	COG1129	ABC transporter
H4O80_RS08010	COG1940	carbohydrate kinase activity
H4O80_RS08025	COG1946	Acyl-CoA thioesterase
H4O80_RS08035	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
H4O80_RS08040	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H4O80_RS08050	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H4O80_RS08055	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
H4O80_RS08095	COG1454	alcohol dehydrogenase
H4O80_RS08100	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H4O80_RS08120	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H4O80_RS08135	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
H4O80_RS08140	COG1687	branched-chain amino acid
H4O80_RS08145	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H4O80_RS08165	COG0589	response to stress
H4O80_RS08170	COG0791	NLP P60 protein
H4O80_RS08180	COG1705	Flagellar rod assembly protein muramidase FlgJ
H4O80_RS08180	COG3942	CHAP domain
H4O80_RS08185	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
H4O80_RS08195	COG5002	protein histidine kinase activity
H4O80_RS08200	COG0704	Plays a role in the regulation of phosphate uptake
H4O80_RS08210	COG1575	Belongs to the MenA family. Type 1 subfamily
H4O80_RS08215	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
H4O80_RS08225	COG2814	Major facilitator Superfamily
H4O80_RS08260	COG2197	response regulator
H4O80_RS08285	COG0395	ABC-type sugar transport system, permease component
H4O80_RS08290	COG1175	transmembrane transport
H4O80_RS08315	COG1803	Methylglyoxal synthase
H4O80_RS08315	COG1597	lipid kinase activity
H4O80_RS08320	COG3711	transcriptional antiterminator
H4O80_RS08350	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H4O80_RS08360	COG0328	RNA-DNA hybrid ribonuclease activity
H4O80_RS08385	COG0196	riboflavin kinase activity
H4O80_RS08420	COG3534	alpha-L-arabinofuranosidase
H4O80_RS08435	COG2308	Evidence 4 Homologs of previously reported genes of
H4O80_RS08540	COG0255	Belongs to the universal ribosomal protein uL29 family
H4O80_RS08595	COG1012	belongs to the aldehyde dehydrogenase family
H4O80_RS08595	COG1454	alcohol dehydrogenase
H4O80_RS08610	COG1063	alcohol dehydrogenase
H4O80_RS08630	COG1063	alcohol dehydrogenase
H4O80_RS08660	COG1739	Uncharacterized protein family UPF0029
H4O80_RS08665	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H4O80_RS08685	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H4O80_RS08700	COG0531	amino acid
H4O80_RS08705	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H4O80_RS08730	COG0626	cystathionine gamma-synthase activity
H4O80_RS08795	COG2252	PERMEase
H4O80_RS08850	COG2826	transposase and inactivated derivatives, IS30 family
H4O80_RS08865	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H4O80_RS08870	COG4770	biotin carboxylase activity
H4O80_RS08875	COG1268	BioY protein
H4O80_RS08945	COG0250	Participates in transcription elongation, termination and antitermination
H4O80_RS08950	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H4O80_RS08960	COG0436	Aminotransferase
H4O80_RS08985	COG1530	ribonuclease E activity
H4O80_RS08990	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H4O80_RS09020	COG0083	homoserine kinase activity
H4O80_RS09025	COG0460	homoserine dehydrogenase
H4O80_RS09040	COG1309	transcriptional regulator
H4O80_RS09050	COG0583	DNA-binding transcription factor activity
H4O80_RS09060	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H4O80_RS09065	COG0446	pyridine nucleotide-disulphide oxidoreductase
H4O80_RS09070	COG0167	dihydroorotate dehydrogenase activity
H4O80_RS09095	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
H4O80_RS09100	COG0494	nUDIX hydrolase
H4O80_RS09100	COG0406	alpha-ribazole phosphatase activity
H4O80_RS09125	COG0584	glycerophosphoryl diester phosphodiesterase
H4O80_RS09140	COG2986	histidine ammonia-lyase
H4O80_RS09155	COG0179	Fumarylacetoacetate (FAA) hydrolase
H4O80_RS09170	COG1088	dTDP-glucose 4,6-dehydratase activity
H4O80_RS09175	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H4O80_RS09230	COG1442	glycosyl transferase family 8
H4O80_RS09230	COG1216	Glycosyl transferase, family 2
H4O80_RS09295	COG1442	glycosyl transferase family 8
H4O80_RS09305	COG1088	dTDP-glucose 4,6-dehydratase activity
H4O80_RS09325	COG1129	ABC transporter
H4O80_RS09335	COG2826	transposase and inactivated derivatives, IS30 family
H4O80_RS09350	COG0084	hydrolase, TatD family'
H4O80_RS09360	COG1132	(ABC) transporter
H4O80_RS09365	COG1132	(ABC) transporter
H4O80_RS09375	COG1609	Transcriptional regulator
H4O80_RS09440	COG1132	(ABC) transporter
H4O80_RS09450	COG1846	Transcriptional regulator
H4O80_RS09475	COG1113	amino acid transport
H4O80_RS09485	COG1136	(ABC) transporter
H4O80_RS09485	COG0577	efflux transmembrane transporter activity
H4O80_RS09495	COG1113	amino acid transport
H4O80_RS09505	COG3507	Belongs to the glycosyl hydrolase 43 family
H4O80_RS09545	COG1609	Transcriptional regulator
H4O80_RS09555	COG0588	phosphoglycerate mutase activity
H4O80_RS09565	COG0778	Nitroreductase
H4O80_RS09600	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H4O80_RS09605	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H4O80_RS09610	COG0366	Alpha amylase catalytic
H4O80_RS09620	COG0395	ABC-type sugar transport system, permease component
H4O80_RS09625	COG1175	transmembrane transport
H4O80_RS09645	COG0590	tRNA wobble adenosine to inosine editing
H4O80_RS09645	COG0037	tRNA processing
H4O80_RS09650	COG0025	NhaP-type Na H and K H
H4O80_RS09655	COG0730	response to heat
H4O80_RS09680	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
H4O80_RS09695	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H4O80_RS09705	COG3842	ATPase activity
H4O80_RS09710	COG1216	Glycosyl transferase, family 2
H4O80_RS09730	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H4O80_RS09750	COG1472	Belongs to the glycosyl hydrolase 3 family
H4O80_RS09770	COG1472	Belongs to the glycosyl hydrolase 3 family
H4O80_RS09790	COG3583	domain protein
H4O80_RS09810	COG0617	tRNA 3'-terminal CCA addition
H4O80_RS09855	COG0366	Alpha amylase catalytic
H4O80_RS09860	COG1609	Transcriptional regulator
H4O80_RS09870	COG1175	transmembrane transport
H4O80_RS09875	COG0395	ABC-type sugar transport system, permease component
H4O80_RS09880	COG3328	transposase activity
H4O80_RS09885	COG1475	DNA binding
H4O80_RS09890	COG1192	Involved in chromosome partitioning