locus-tag	class	description
BL0001	COG1278	Cold shock
BL0005	COG0745	RESPONSE REGULATOR receiver
BL0006	COG2205	protein histidine kinase activity
BL0007	COG1278	Cold shock
BL0009	COG0589	response to stress
BL0011	COG0402	S-adenosylhomocysteine deaminase activity
BL0013	COG0477	Major facilitator Superfamily
BL0014	COG1402	creatininase
BL0016	COG1196	nuclear chromosome segregation
BL0021	COG1126	abc transporter atp-binding protein
BL0022	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BL0023	COG0765	amino acid transport
BL0024	COG0765	amino acid transport
BL0027	COG2326	polyphosphate kinase activity
BL0028	COG4581	dead DEAH box helicase
BL0030	COG0745	RESPONSE REGULATOR receiver
BL0037	COG2814	Major facilitator Superfamily
BL0038	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BL0045	COG1216	Glycosyl transferase, family 2
BL0049	COG1122	ATPase activity
BL0055	COG0395	ABC-type sugar transport system, permease component
BL0058	COG1250	3-hydroxyacyl-CoA dehydrogenase
BL0060	COG4106	trans-aconitate 2-methyltransferase activity
BL0062	COG1376	ErfK ybiS ycfS ynhG family protein
BL0063	COG0390	transport system, permease component
BL0064	COG1136	(ABC) transporter
BL0064	COG0577	efflux transmembrane transporter activity
BL0069	COG0284	orotidine-5'-phosphate decarboxylase activity
BL0072	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BL0075	COG0765	amino acid transport
BL0076	COG1126	abc transporter atp-binding protein
BL0077	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BL0078	COG0626	cystathionine gamma-synthase activity
BL0083	COG2873	o-acetylhomoserine
BL0087	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BL0094	COG3480	Lon protease (S16) C-terminal proteolytic domain
BL0102	COG1957	nucleoside hydrolase
BL0104	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BL0111	COG2271	Major facilitator Superfamily
BL0113	COG0351	phosphomethylpyrimidine kinase
BL0113	COG0352	thiamine-phosphate diphosphorylase activity
BL0118	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BL0124	COG1373	ATPase (AAA superfamily
BL0127	COG0587	DNA-directed DNA polymerase activity
BL0129	COG4716	Myosin-crossreactive antigen
BL0139	COG0778	Nitroreductase
BL0140	COG0588	phosphoglycerate mutase activity
BL0142	COG1609	Transcriptional regulator
BL0152	COG1113	amino acid transport
BL0156	COG1113	amino acid transport
BL0159	COG3645	SOS response
BL0160	COG1846	Transcriptional regulator
BL0163	COG1132	(ABC) transporter
BL0176	COG1609	Transcriptional regulator
BL0179	COG1132	(ABC) transporter
BL0180	COG1132	(ABC) transporter
BL0182	COG3507	Belongs to the glycosyl hydrolase 43 family
BL0183	COG3507	Belongs to the glycosyl hydrolase 43 family
BL0185	COG1609	Transcriptional regulator
BL0187	COG3940	Belongs to the glycosyl hydrolase 43 family
BL0189	COG1175	transmembrane transport
BL0190	COG0395	ABC-type sugar transport system, permease component
BL0193	COG0084	hydrolase, TatD family'
BL0197	COG1129	ABC transporter
BL0203	COG1368	sulfuric ester hydrolase activity
BL0209	COG3475	LICD family
BL0210	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
BL0213	COG1216	Glycosyl transferase, family 2
BL0216	COG1216	Glycosyl transferase, family 2
BL0217	COG1216	Glycosyl transferase, family 2
BL0229	COG1088	dTDP-glucose 4,6-dehydratase activity
BL0231	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
BL0237	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BL0241	COG4974	Belongs to the 'phage' integrase family
BL0244	COG4974	Belongs to the 'phage' integrase family
BL0248	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BL0251	COG2814	Major facilitator Superfamily
BL0255	COG0656	L-ascorbic acid biosynthetic process
BL0257	COG3867	Arabinogalactan endo-beta-1,4-galactanase
BL0260	COG0395	ABC-type sugar transport system, permease component
BL0261	COG1175	transmembrane transport
BL0262	COG1653	transport
BL0263	COG2814	Major facilitator Superfamily
BL0264	COG4988	ABC transporter
BL0265	COG2814	Major facilitator Superfamily
BL0269	COG0577	efflux transmembrane transporter activity
BL0271	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
BL0275	COG1609	Transcriptional regulator
BL0276	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BL0283	COG2348	transferase activity, transferring amino-acyl groups
BL0290	COG0667	Aldo Keto reductase
BL0297	COG0440	acetolactate synthase activity
BL0299	COG0488	(ABC) transporter
BL0300	COG0505	Belongs to the CarA family
BL0306	COG1837	Belongs to the UPF0109 family
BL0308	COG1957	nucleoside hydrolase
BL0311	COG1704	LemA family
BL0316	COG0745	RESPONSE REGULATOR receiver
BL0317	COG5002	protein histidine kinase activity
BL0318	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BL0319	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BL0320	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BL0321	COG3579	cysteine-type endopeptidase activity
BL0323	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
BL0325	COG1496	oxidoreductase activity
BL0326	COG0826	peptidase U32
BL0328	COG0742	ribosomal rna small subunit methyltransferase
BL0331	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
BL0331	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
BL0332	COG2270	Major facilitator Superfamily
BL0335	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BL0338	COG1027	Aspartate ammonia-lyase
BL0341	COG3842	ATPase activity
BL0348	COG0251	oxidation-reduction process
BL0354	COG0545	Peptidyl-prolyl cis-trans isomerase
BL0356	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BL0363	COG0356	it plays a direct role in the translocation of protons across the membrane
BL0386	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
BL0389	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BL0392	COG0745	RESPONSE REGULATOR receiver
BL0397	COG1605	Chorismate mutase
BL0397	COG0287	Prephenate dehydrogenase
BL0405	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BL0407	COG1322	Protein conserved in bacteria
BL0408	COG1937	Protein conserved in bacteria
BL0410	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BL0411	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BL0412	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BL0419	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BL0423	COG0395	ABC-type sugar transport system, permease component
BL0424	COG1175	transmembrane transport
BL0426	COG1609	Transcriptional regulator
BL0429	COG3442	glutamine amidotransferase
BL0430	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BL0431	COG0305	Participates in initiation and elongation during chromosome replication
BL0433	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
BL0437	COG1309	transcriptional regulator
BL0438	COG1215	transferase activity, transferring glycosyl groups
BL0443	COG0363	glucosamine-6-phosphate deaminase activity
BL0444	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BL0450	COG1136	(ABC) transporter
BL0451	COG0577	efflux transmembrane transporter activity
BL0454	COG3470	protein probably involved in high-affinity Fe2 transport
BL0455	COG0672	)-iron permease
BL0457	COG2910	NAD(P)H-binding
BL0458	COG1733	regulation of RNA biosynthetic process
BL0460	COG0583	DNA-binding transcription factor activity
BL0464	COG0366	Alpha amylase catalytic
BL0472	COG0676	glucose-6-phosphate 1-epimerase activity
BL0485	COG1754	DNA topoisomerase type I activity
BL0485	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BL0487	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BL0493	COG0527	aspartate kinase activity
BL0510	COG0586	Pfam SNARE associated Golgi protein
BL0511	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BL0512	COG1028	Short-chain dehydrogenase reductase Sdr
BL0516	COG0789	Transcriptional regulator
BL0524	COG0395	ABC-type sugar transport system, permease component
BL0525	COG1609	Transcriptional regulator
BL0529	COG0366	Alpha amylase catalytic
BL0532	COG0477	Major facilitator Superfamily
BL0538	COG4974	Belongs to the 'phage' integrase family
BL0544	COG3534	alpha-L-arabinofuranosidase
BL0550	COG0191	fructose-bisphosphate aldolase activity
BL0556	COG0343	queuine tRNA-ribosyltransferase activity
BL0570	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
BL0576	COG0071	Belongs to the small heat shock protein (HSP20) family
BL0587	COG0768	penicillin binding
BL0588	COG0515	serine threonine protein kinase
BL0597	COG0058	SHG alpha-glucan phosphorylase activity
BL0600	COG0180	Tryptophanyl-tRNA synthetase
BL0601	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BL0602	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BL0604	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
BL0610	COG1609	Transcriptional regulator
BL0617	COG1253	flavin adenine dinucleotide binding
BL0618	COG0783	Belongs to the Dps family
BL0620	COG3265	gluconokinase activity
BL0628	COG0436	Aminotransferase
BL0629	COG1522	sequence-specific DNA binding
BL0630	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BL0631	COG0542	response to heat
BL0633	COG3266	domain, Protein
BL0634	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BL0635	COG0187	DNA topoisomerase II activity
BL0638	COG0592	DNA-directed DNA polymerase activity
BL0647	COG1192	Involved in chromosome partitioning
BL0648	COG1475	DNA binding
BL0654	COG0617	tRNA 3'-terminal CCA addition
BL0658	COG3583	domain protein
BL0664	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BL0670	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BL0672	COG1215	transferase activity, transferring glycosyl groups
BL0673	COG3842	ATPase activity
BL0680	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BL0683	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BL0689	COG0488	(ABC) transporter
BL0690	COG1028	Short-chain dehydrogenase reductase Sdr
BL0693	COG1129	ABC transporter
BL0704	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BL0709	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BL0712	COG0436	Aminotransferase
BL0715	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BL0732	COG0045	succinate-CoA ligase (ADP-forming) activity
BL0736	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BL0737	COG1187	pseudouridine synthase activity
BL0747	COG1716	ATPase activity
BL0750	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BL0753	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BL0756	COG0133	tryptophan synthase activity
BL0758	COG0833	amino acid
BL0774	COG1051	belongs to the nudix hydrolase family
BL0775	COG0706	membrane insertase activity
BL0776	COG0706	membrane insertase activity
BL0778	COG0833	amino acid
BL0779	COG0681	Belongs to the peptidase S26 family
BL0786	COG0583	DNA-binding transcription factor activity
BL0789	COG0167	dihydroorotate dehydrogenase activity
BL0790	COG0543	2 iron, 2 sulfur cluster binding
BL0791	COG0284	orotidine-5'-phosphate decarboxylase activity
BL0792	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BL0797	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BL0799	COG0588	phosphoglycerate mutase activity
BL0804	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
BL0806	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
BL0822	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BL0824	COG0561	phosphatase activity
BL0825	COG1119	ATPase activity
BL0826	COG0297	glycogen (starch) synthase activity
BL0829	COG4166	transmembrane transport
BL0834	COG0070	glutamate synthase
BL0834	COG0069	glutamate synthase activity
BL0834	COG0067	glutamate synthase
BL0835	COG1609	Transcriptional regulator
BL0838	COG1609	Transcriptional regulator
BL0845	COG1929	Belongs to the glycerate kinase type-1 family
BL0850	COG2860	membrane
BL0852	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BL0857	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
BL0862	COG1702	phosphate starvation-inducible protein PhoH
BL0863	COG0537	adenosine 5'-monophosphoramidase activity
BL0864	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BL0867	COG2151	metal-sulfur cluster biosynthetic enzyme
BL0869	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BL0870	COG0396	ATPase activity
BL0871	COG0719	Fe-S assembly protein
BL0876	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BL0884	COG0588	phosphoglycerate mutase activity
BL0885	COG2755	lipolytic protein G-D-S-L family
BL0885	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
BL0887	COG0577	efflux transmembrane transporter activity
BL0887	COG1136	(ABC) transporter
BL0893	COG3655	Transcriptional regulator
BL0901	COG1131	(ABC) transporter
BL0902	COG4585	Histidine kinase
BL0903	COG2197	response regulator
BL0905	COG0306	phosphate transporter
BL0906	COG1966	Carbon starvation protein
BL0908	COG1309	transcriptional regulator
BL0909	COG0513	Belongs to the DEAD box helicase family
BL0910	COG2233	PERMEase
BL0918	COG0515	serine threonine protein kinase
BL0918	COG2815	serine threonine protein kinase
BL0920	COG2814	Major facilitator Superfamily
BL0926	COG0012	GTP binding
BL0927	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BL0929	COG4585	Histidine kinase
BL0930	COG2197	response regulator
BL0931	COG1136	(ABC) transporter
BL0931	COG0577	efflux transmembrane transporter activity
BL0932	COG1136	(ABC) transporter
BL0933	COG2873	o-acetylhomoserine
BL0937	COG0758	DNA mediated transformation
BL0938	COG1053	succinate dehydrogenase
BL0941	COG1611	Belongs to the LOG family
BL0950	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
BL0951	COG1882	Formate acetyltransferase
BL0954	COG1473	amidohydrolase
BL0955	COG2011	ABC-type metal ion transport system permease component
BL0965	COG0799	negative regulation of ribosome biogenesis
BL0966	COG0406	alpha-ribazole phosphatase activity
BL0968	COG0857	belongs to the CobB CobQ family
BL0968	COG0280	phosphate acetyltransferase
BL0969	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BL0978	COG3250	beta-galactosidase activity
BL0979	COG0519	Catalyzes the synthesis of GMP from XMP
BL0983	COG1051	belongs to the nudix hydrolase family
BL0984	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BL0987	COG0494	nUDIX hydrolase
BL0988	COG0469	pyruvate kinase activity
BL0992	COG0539	negative regulation of cytoplasmic translation
BL0994	COG0803	Belongs to the bacterial solute-binding protein 9 family
BL0995	COG1121	(ABC) transporter
BL0998	COG1329	Transcriptional regulator
BL1000	COG0745	RESPONSE REGULATOR receiver
BL1001	COG2205	protein histidine kinase activity
BL1003	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BL1009	COG1316	TRANSCRIPTIONal
BL1015	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BL1017	COG1760	l-serine dehydratase
BL1023	COG0667	Aldo Keto reductase
BL1027	COG2116	formate transmembrane transporter activity
BL1028	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BL1028	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BL1032	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BL1038	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BL1042	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BL1043	COG0497	DNA recombination
BL1045	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BL1046	COG0569	domain protein
BL1053a	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BL1054	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BL1068	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BL1070	COG1122	ATPase activity
BL1071	COG4721	ABC-type cobalt transport system, permease component
BL1072	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BL1079	COG0110	maltose O-acetyltransferase activity
BL1080	COG0110	maltose O-acetyltransferase activity
BL1083	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BL1090	COG1063	alcohol dehydrogenase
BL1102	COG0385	Bile acid
BL1108	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BL1113	COG0667	Aldo Keto reductase
BL1114	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BL1115	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
BL1116	COG0402	S-adenosylhomocysteine deaminase activity
BL1118	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BL1124	COG1012	belongs to the aldehyde dehydrogenase family
BL1129	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BL1130	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BL1132	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BL1133	COG1136	(ABC) transporter
BL1133	COG0577	efflux transmembrane transporter activity
BL1135	COG0577	efflux transmembrane transporter activity
BL1135	COG1136	(ABC) transporter
BL1137	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BL1140	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
BL1144	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BL1147	COG0358	DNA primase activity
BL1149	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BL1150	COG0531	amino acid
BL1153	COG0514	ATP-dependent DNA helicase (RecQ)
BL1155	COG0626	cystathionine gamma-synthase activity
BL1157	COG4608	Belongs to the ABC transporter superfamily
BL1159	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BL1160	COG0601	transmembrane transport
BL1161	COG0747	negative chemotaxis
BL1164	COG1653	transport
BL1165	COG1653	transport
BL1166	COG3534	alpha-L-arabinofuranosidase
BL1169	COG0395	ABC-type sugar transport system, permease component
BL1170	COG1175	transmembrane transport
BL1173	COG3550	peptidyl-serine autophosphorylation
BL1174	COG0564	pseudouridine synthase activity
BL1181	COG1388	LysM domain
BL1181	COG3942	CHAP domain
BL1182	COG2177	Part of the ABC transporter FtsEX involved in
BL1183	COG2884	Cell division ATP-binding protein ftsE
BL1184	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BL1192	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BL1199a	COG0714	Associated with various cellular activities
BL1207	COG1194	a g-specific adenine glycosylase
BL1208	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BL1210	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
BL1212	COG1349	DNA-binding transcription factor activity
BL1213	COG0167	dihydroorotate dehydrogenase activity
BL1214	COG1902	pentaerythritol trinitrate reductase activity
BL1215	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BL1215	COG4499	WXG100 protein secretion system (Wss), protein YukC
BL1217	COG0095	Lipoate-protein ligase
BL1226	COG3118	belongs to the thioredoxin family
BL1226	COG0492	ferredoxin-NADP+ reductase activity
BL1229	COG0489	protein tyrosine kinase activity
BL1243	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BL1244	COG1088	dTDP-glucose 4,6-dehydratase activity
BL1247	COG0179	Fumarylacetoacetate (FAA) hydrolase
BL1249	COG2986	histidine ammonia-lyase
BL1252	COG0584	glycerophosphoryl diester phosphodiesterase
BL1258	COG0494	nUDIX hydrolase
BL1258	COG0406	alpha-ribazole phosphatase activity
BL1259	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BL1265	COG0167	dihydroorotate dehydrogenase activity
BL1266	COG0446	pyridine nucleotide-disulphide oxidoreductase
BL1267	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BL1271	COG1309	transcriptional regulator
BL1274	COG0460	homoserine dehydrogenase
BL1275	COG0083	homoserine kinase activity
BL1280	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BL1281	COG1530	ribonuclease E activity
BL1286	COG0436	Aminotransferase
BL1287	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BL1288	COG0250	Participates in transcription elongation, termination and antitermination
BL1292	COG0656	L-ascorbic acid biosynthetic process
BL1302	COG0174	glutamine synthetase
BL1305	COG1643	Atp-dependent helicase
BL1306	COG2813	Specifically methylates the guanine in position
BL1307	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BL1313	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BL1317	COG0768	penicillin binding
BL1319	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BL1325	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BL1331	COG1175	transmembrane transport
BL1332	COG0395	ABC-type sugar transport system, permease component
BL1341	COG1940	carbohydrate kinase activity
BL1345	COG4166	transmembrane transport
BL1346	COG0601	transmembrane transport
BL1350	COG0006	proline dipeptidase activity
BL1353	COG0285	dihydrofolate synthase activity
BL1354	COG1196	nuclear chromosome segregation
BL1357	COG1595	DNA-templated transcription, initiation
BL1359	COG2017	converts alpha-aldose to the beta-anomer
BL1360	COG2017	converts alpha-aldose to the beta-anomer
BL1362	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BL1366	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BL1369	COG1136	(ABC) transporter
BL1369	COG0577	efflux transmembrane transporter activity
BL1371	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
BL1372	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BL1374	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
BL1375	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
BL1377	COG1104	cysteine desulfurase activity
BL1378	COG0477	Major facilitator Superfamily
BL1379	COG1217	gtp-binding protein TYPA
BL1381	COG0077	Prephenate dehydratase
BL1381	COG1605	Chorismate mutase
BL1382	COG0287	Prephenate dehydrogenase
BL1386	COG4166	transmembrane transport
BL1387	COG0601	transmembrane transport
BL1389	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BL1391	COG0708	Exodeoxyribonuclease III
BL1402	COG2197	response regulator
BL1405	COG0670	Belongs to the BI1 family
BL1407	COG2357	RelA SpoT domain protein
BL1413	COG1058	Belongs to the CinA family
BL1413	COG1546	Belongs to the CinA family
BL1414	COG1396	sequence-specific DNA binding
BL1418	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
BL1422	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BL1426	COG0142	geranyltranstransferase activity
BL1428	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BL1429	COG0187	DNA topoisomerase II activity
BL1431	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BL1432	COG1201	RNA secondary structure unwinding
BL1434	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BL1439	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BL1447	COG0406	alpha-ribazole phosphatase activity
BL1448	COG0598	Magnesium transport protein CorA
BL1449	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BL1451	COG1596	polysaccharide export
BL1451	COG1555	photosystem II stabilization
BL1453	COG1228	amidohydrolase
BL1456	COG0456	acetyltransferase
BL1467	COG3942	CHAP domain
BL1469	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BL1469	COG0551	DNA topoisomerase type I activity
BL1492	COG1192	Involved in chromosome partitioning
BL1500	COG0516	GMP reductase activity
BL1507	COG0575	Belongs to the CDS family
BL1509	COG0693	protein deglycase activity
BL1515	COG0730	response to heat
BL1516	COG0025	NhaP-type Na H and K H
BL1517	COG0590	tRNA wobble adenosine to inosine editing
BL1517	COG0037	tRNA processing
BL1522	COG1175	transmembrane transport
BL1523	COG0395	ABC-type sugar transport system, permease component
BL1526	COG0366	Alpha amylase catalytic
BL1527	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BL1528	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BL1534	COG1268	BioY protein
BL1535	COG4770	biotin carboxylase activity
BL1536	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BL1543	COG3507	Belongs to the glycosyl hydrolase 43 family
BL1544	COG3507	Belongs to the glycosyl hydrolase 43 family
BL1547	COG2252	PERMEase
BL1559	COG0626	cystathionine gamma-synthase activity
BL1561	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BL1562	COG0531	amino acid
BL1565	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BL1568	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BL1569	COG1739	Uncharacterized protein family UPF0029
BL1575	COG1454	alcohol dehydrogenase
BL1575	COG1012	belongs to the aldehyde dehydrogenase family
BL1588	COG0255	Belongs to the universal ribosomal protein uL29 family
BL1609	COG2308	Evidence 4 Homologs of previously reported genes of
BL1611	COG3534	alpha-L-arabinofuranosidase
BL1619	COG0196	riboflavin kinase activity
BL1624	COG0328	RNA-DNA hybrid ribonuclease activity
BL1626	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BL1633	COG3711	transcriptional antiterminator
BL1634	COG1803	Methylglyoxal synthase
BL1634	COG1597	lipid kinase activity
BL1639	COG1175	transmembrane transport
BL1640	COG0395	ABC-type sugar transport system, permease component
BL1645	COG2197	response regulator
BL1652	COG2814	Major facilitator Superfamily
BL1654	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BL1655	COG1575	Belongs to the MenA family. Type 1 subfamily
BL1657	COG0704	Plays a role in the regulation of phosphate uptake
BL1658	COG5002	protein histidine kinase activity
BL1660	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BL1661	COG1705	Flagellar rod assembly protein muramidase FlgJ
BL1661	COG3942	CHAP domain
BL1663	COG0791	NLP P60 protein
BL1664	COG0589	response to stress
BL1667	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BL1668	COG1687	branched-chain amino acid
BL1669	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
BL1671	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BL1672	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BL1673	COG1454	alcohol dehydrogenase
BL1681	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
BL1682	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BL1684	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BL1685	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BL1687	COG1946	Acyl-CoA thioesterase
BL1691	COG1940	carbohydrate kinase activity
BL1692	COG1129	ABC transporter
BL1696	COG4214	carbohydrate transport
BL1699	COG2814	Major facilitator Superfamily
BL1700	COG0242	peptide deformylase activity
BL1702	COG2814	Major facilitator Superfamily
BL1703	COG2814	Major facilitator Superfamily
BL1706	COG4211	Belongs to the binding-protein-dependent transport system permease family
BL1709	COG1070	Carbohydrate kinase
BL1719	COG0110	maltose O-acetyltransferase activity
BL1720	COG0009	L-threonylcarbamoyladenylate synthase
BL1721	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BL1724	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BL1725	COG1355	regulation of microtubule-based process
BL1730	COG3590	peptidase
BL1741	COG0436	Aminotransferase
BL1742	COG0248	Ppx GppA phosphatase
BL1747	COG1970	mechanosensitive ion channel activity
BL1748	COG1022	Amp-dependent synthetase and ligase
BL1749	COG2249	NAD(P)H dehydrogenase (quinone) activity
BL1750	COG1722	exodeoxyribonuclease VII activity
BL1751	COG1570	exodeoxyribonuclease VII activity
BL1752	COG1328	CTP reductase activity
BL1752	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BL1753	COG0602	queuosine metabolic process
BL1756	COG1309	transcriptional regulator
BL1763	COG1472	Belongs to the glycosyl hydrolase 3 family
BL1764	COG1472	Belongs to the glycosyl hydrolase 3 family
BL1766	COG1132	(ABC) transporter
BL1767	COG1132	(ABC) transporter
BL1771	COG3069	C4-dicarboxylate transmembrane transporter activity
BL1772	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BL1774	COG1609	Transcriptional regulator
BL1775	COG3250	beta-galactosidase activity
BL1776	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
BL1781	COG1715	Restriction endonuclease
BL1785	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BL1791	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BL1792	COG0560	Phosphoserine phosphatase
BL1793	COG0586	Pfam SNARE associated Golgi protein
BL1795	COG4122	O-methyltransferase activity
BL1800	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BL1811	COG0714	Associated with various cellular activities