locus-tag	class	description
RY67_RS00035	COG0667	Aldo Keto reductase
RY67_RS00045	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
RY67_RS00065	COG1131	(ABC) transporter
RY67_RS00095	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
RY67_RS00100	COG0402	S-adenosylhomocysteine deaminase activity
RY67_RS00110	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RY67_RS00140	COG1012	belongs to the aldehyde dehydrogenase family
RY67_RS00160	COG0701	Predicted permease
RY67_RS00195	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
RY67_RS00200	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
RY67_RS00210	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
RY67_RS00215	COG0577	efflux transmembrane transporter activity
RY67_RS00215	COG0577	efflux transmembrane transporter activity
RY67_RS00225	COG0577	efflux transmembrane transporter activity
RY67_RS00225	COG1136	(ABC) transporter
RY67_RS00240	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
RY67_RS00255	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
RY67_RS00260	COG1373	ATPase (AAA superfamily
RY67_RS00270	COG4770	biotin carboxylase activity
RY67_RS00275	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
RY67_RS00280	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
RY67_RS00295	COG2801	Transposase and inactivated derivatives
RY67_RS00320	COG2826	transposase and inactivated derivatives, IS30 family
RY67_RS00340	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RY67_RS00355	COG3655	Transcriptional regulator
RY67_RS00365	COG0358	DNA primase activity
RY67_RS00375	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
RY67_RS00380	COG0531	amino acid
RY67_RS00395	COG0514	ATP-dependent DNA helicase (RecQ)
RY67_RS00405	COG0626	cystathionine gamma-synthase activity
RY67_RS00430	COG4608	Belongs to the ABC transporter superfamily
RY67_RS00450	COG0747	negative chemotaxis
RY67_RS00455	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
RY67_RS00480	COG0564	pseudouridine synthase activity
RY67_RS00485	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
RY67_RS00520	COG2177	Part of the ABC transporter FtsEX involved in
RY67_RS00525	COG2884	Cell division ATP-binding protein ftsE
RY67_RS00530	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
RY67_RS00555	COG1175	transmembrane transport
RY67_RS00560	COG0395	ABC-type sugar transport system, permease component
RY67_RS00565	COG1653	transport
RY67_RS00580	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
RY67_RS00600	COG0210	DNA helicase
RY67_RS00620	COG0714	Associated with various cellular activities
RY67_RS00670	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
RY67_RS00685	COG2814	Major facilitator Superfamily
RY67_RS00695	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
RY67_RS00710	COG0477	Major facilitator Superfamily
RY67_RS00725	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
RY67_RS00735	COG1349	DNA-binding transcription factor activity
RY67_RS00740	COG0167	dihydroorotate dehydrogenase activity
RY67_RS00745	COG1902	pentaerythritol trinitrate reductase activity
RY67_RS00750	COG4499	WXG100 protein secretion system (Wss), protein YukC
RY67_RS00750	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
RY67_RS00760	COG0095	Lipoate-protein ligase
RY67_RS00820	COG0489	protein tyrosine kinase activity
RY67_RS00835	COG0758	DNA mediated transformation
RY67_RS00865	COG1088	dTDP-glucose 4,6-dehydratase activity
RY67_RS00870	COG0438	transferase activity, transferring glycosyl groups
RY67_RS00875	COG0438	transferase activity, transferring glycosyl groups
RY67_RS00890	COG0438	transferase activity, transferring glycosyl groups
RY67_RS00900	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
RY67_RS00915	COG4641	Protein conserved in bacteria
RY67_RS00915	COG0438	transferase activity, transferring glycosyl groups
RY67_RS00955	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
RY67_RS01030	COG0586	Pfam SNARE associated Golgi protein
RY67_RS01035	COG0560	Phosphoserine phosphatase
RY67_RS01040	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
RY67_RS01070	COG0577	efflux transmembrane transporter activity
RY67_RS01085	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
RY67_RS01105	COG0589	response to stress
RY67_RS01110	COG0791	NLP P60 protein
RY67_RS01120	COG3942	CHAP domain
RY67_RS01120	COG1705	Flagellar rod assembly protein muramidase FlgJ
RY67_RS01125	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
RY67_RS01135	COG5002	protein histidine kinase activity
RY67_RS01140	COG0704	Plays a role in the regulation of phosphate uptake
RY67_RS01150	COG1575	Belongs to the MenA family. Type 1 subfamily
RY67_RS01155	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
RY67_RS01165	COG2814	Major facilitator Superfamily
RY67_RS01205	COG2197	response regulator
RY67_RS01230	COG0395	ABC-type sugar transport system, permease component
RY67_RS01235	COG1175	transmembrane transport
RY67_RS01255	COG1597	lipid kinase activity
RY67_RS01255	COG1803	Methylglyoxal synthase
RY67_RS01260	COG3711	transcriptional antiterminator
RY67_RS01290	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RY67_RS01295	COG0328	RNA-DNA hybrid ribonuclease activity
RY67_RS01320	COG0196	riboflavin kinase activity
RY67_RS01360	COG0395	ABC-type sugar transport system, permease component
RY67_RS01365	COG1175	transmembrane transport
RY67_RS01390	COG2308	Evidence 4 Homologs of previously reported genes of
RY67_RS01495	COG0255	Belongs to the universal ribosomal protein uL29 family
RY67_RS01550	COG1012	belongs to the aldehyde dehydrogenase family
RY67_RS01550	COG1454	alcohol dehydrogenase
RY67_RS01585	COG1739	Uncharacterized protein family UPF0029
RY67_RS01590	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
RY67_RS01600	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
RY67_RS01615	COG0531	amino acid
RY67_RS01620	COG0812	UDP-N-acetylmuramate dehydrogenase activity
RY67_RS01710	COG2252	PERMEase
RY67_RS01725	COG1132	(ABC) transporter
RY67_RS01730	COG1122	ATPase activity
RY67_RS01870	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
RY67_RS01875	COG4770	biotin carboxylase activity
RY67_RS01940	COG0250	Participates in transcription elongation, termination and antitermination
RY67_RS01945	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
RY67_RS01955	COG0436	Aminotransferase
RY67_RS01980	COG1530	ribonuclease E activity
RY67_RS01985	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RY67_RS01995	COG4154	Belongs to the RbsD FucU family
RY67_RS02010	COG1028	Short-chain dehydrogenase reductase Sdr
RY67_RS02015	COG4948	Mandelate Racemase Muconate Lactonizing
RY67_RS02020	COG1609	Transcriptional regulator
RY67_RS02030	COG1136	(ABC) transporter
RY67_RS02040	COG0083	homoserine kinase activity
RY67_RS02045	COG0460	homoserine dehydrogenase
RY67_RS02070	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
RY67_RS02075	COG0446	pyridine nucleotide-disulphide oxidoreductase
RY67_RS02090	COG0167	dihydroorotate dehydrogenase activity
RY67_RS02115	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
RY67_RS02120	COG0494	nUDIX hydrolase
RY67_RS02120	COG0406	alpha-ribazole phosphatase activity
RY67_RS02140	COG3250	beta-galactosidase activity
RY67_RS02155	COG4154	Belongs to the RbsD FucU family
RY67_RS02160	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RY67_RS02170	COG4948	Mandelate Racemase Muconate Lactonizing
RY67_RS02180	COG0395	ABC-type sugar transport system, permease component
RY67_RS02185	COG4209	transmembrane transport
RY67_RS02200	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RY67_RS02270	COG0395	ABC-type sugar transport system, permease component
RY67_RS02280	COG3842	ATPase activity
RY67_RS02315	COG1175	transmembrane transport
RY67_RS02320	COG0584	glycerophosphoryl diester phosphodiesterase
RY67_RS02335	COG0179	Fumarylacetoacetate (FAA) hydrolase
RY67_RS02360	COG0395	ABC-type sugar transport system, permease component
RY67_RS02365	COG1175	transmembrane transport
RY67_RS02390	COG0463	Glycosyl transferase, family 2
RY67_RS02400	COG1216	Glycosyl transferase, family 2
RY67_RS02415	COG1216	Glycosyl transferase, family 2
RY67_RS02425	COG1216	Glycosyl transferase, family 2
RY67_RS02430	COG1088	dTDP-glucose 4,6-dehydratase activity
RY67_RS02450	COG1129	ABC transporter
RY67_RS02470	COG0084	hydrolase, TatD family'
RY67_RS02485	COG1132	(ABC) transporter
RY67_RS02490	COG1132	(ABC) transporter
RY67_RS02520	COG4166	transmembrane transport
RY67_RS02595	COG1132	(ABC) transporter
RY67_RS02605	COG1846	Transcriptional regulator
RY67_RS02610	COG1113	amino acid transport
RY67_RS02620	COG1136	(ABC) transporter
RY67_RS02625	COG1113	amino acid transport
RY67_RS02645	COG1609	Transcriptional regulator
RY67_RS02655	COG0588	phosphoglycerate mutase activity
RY67_RS02665	COG0778	Nitroreductase
RY67_RS02700	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
RY67_RS02705	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
RY67_RS02710	COG0366	Alpha amylase catalytic
RY67_RS02725	COG0395	ABC-type sugar transport system, permease component
RY67_RS02730	COG1175	transmembrane transport
RY67_RS02750	COG0590	tRNA wobble adenosine to inosine editing
RY67_RS02750	COG0037	tRNA processing
RY67_RS02755	COG0025	NhaP-type Na H and K H
RY67_RS02790	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
RY67_RS02800	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RY67_RS02800	COG1263	PTS System
RY67_RS02800	COG2190	(PTS) system
RY67_RS02805	COG1263	PTS System
RY67_RS02805	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RY67_RS02815	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RY67_RS02825	COG3842	ATPase activity
RY67_RS02830	COG1215	transferase activity, transferring glycosyl groups
RY67_RS02840	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
RY67_RS02865	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RY67_RS02895	COG3583	domain protein
RY67_RS02915	COG0617	tRNA 3'-terminal CCA addition
RY67_RS02940	COG1475	DNA binding
RY67_RS02945	COG1192	Involved in chromosome partitioning
RY67_RS02985	COG0592	DNA-directed DNA polymerase activity
RY67_RS03000	COG0187	DNA topoisomerase II activity
RY67_RS03005	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
RY67_RS03010	COG3266	domain, Protein
RY67_RS03015	COG0542	response to heat
RY67_RS03025	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
RY67_RS03030	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
RY67_RS03035	COG3842	ATPase activity
RY67_RS03050	COG1737	Transcriptional regulator
RY67_RS03065	COG3328	transposase activity
RY67_RS03115	COG3639	organic phosphonate transmembrane transporter activity
RY67_RS03130	COG1737	Transcriptional regulator
RY67_RS03160	COG0783	Belongs to the Dps family
RY67_RS03165	COG1253	flavin adenine dinucleotide binding
RY67_RS03175	COG1716	ATPase activity
RY67_RS03175	COG1131	(ABC) transporter
RY67_RS03175	COG0842	Transport permease protein
RY67_RS03210	COG0730	response to heat
RY67_RS03215	COG0641	radical SAM
RY67_RS03220	COG1609	Transcriptional regulator
RY67_RS03225	COG3119	arylsulfatase activity
RY67_RS03245	COG0395	ABC-type sugar transport system, permease component
RY67_RS03250	COG1373	ATPase (AAA superfamily
RY67_RS03290	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
RY67_RS03310	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
RY67_RS03330	COG0180	Tryptophanyl-tRNA synthetase
RY67_RS03340	COG2197	response regulator
RY67_RS03360	COG0058	SHG alpha-glucan phosphorylase activity
RY67_RS03400	COG0515	serine threonine protein kinase
RY67_RS03405	COG0768	penicillin binding
RY67_RS03450	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
RY67_RS03490	COG0071	Belongs to the small heat shock protein (HSP20) family
RY67_RS03510	COG0343	queuine tRNA-ribosyltransferase activity
RY67_RS03530	COG0683	leucine binding
RY67_RS03535	COG0559	Belongs to the binding-protein-dependent transport system permease family
RY67_RS03555	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
RY67_RS03565	COG0804	urea catabolic process
RY67_RS03580	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
RY67_RS03640	COG4974	Belongs to the 'phage' integrase family
RY67_RS03650	COG2188	Transcriptional regulator
RY67_RS03660	COG1397	ADP-ribosylglycohydrolase
RY67_RS03695	COG0191	fructose-bisphosphate aldolase activity
RY67_RS03740	COG0477	Major facilitator Superfamily
RY67_RS03760	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
RY67_RS03765	COG1122	ATPase activity
RY67_RS03770	COG1268	BioY protein
RY67_RS03795	COG0366	Alpha amylase catalytic
RY67_RS03840	COG0789	Transcriptional regulator
RY67_RS03860	COG1028	Short-chain dehydrogenase reductase Sdr
RY67_RS03865	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RY67_RS03870	COG0586	Pfam SNARE associated Golgi protein
RY67_RS03945	COG0527	aspartate kinase activity
RY67_RS03975	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
RY67_RS03995	COG1754	DNA topoisomerase type I activity
RY67_RS03995	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
RY67_RS04020	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
RY67_RS04070	COG0676	glucose-6-phosphate 1-epimerase activity
RY67_RS04075	COG3152	Membrane
RY67_RS04120	COG3619	membrane
RY67_RS04130	COG0477	Major facilitator Superfamily
RY67_RS04145	COG2977	Belongs to the P-Pant transferase superfamily
RY67_RS04170	COG2801	Transposase and inactivated derivatives
RY67_RS04215	COG0672	)-iron permease
RY67_RS04220	COG3470	protein probably involved in high-affinity Fe2 transport
RY67_RS04235	COG0577	efflux transmembrane transporter activity
RY67_RS04240	COG1136	(ABC) transporter
RY67_RS04270	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
RY67_RS04275	COG0363	glucosamine-6-phosphate deaminase activity
RY67_RS04310	COG2197	response regulator
RY67_RS04330	COG1216	Glycosyl transferase, family 2
RY67_RS04335	COG1309	transcriptional regulator
RY67_RS04355	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
RY67_RS04365	COG0305	Participates in initiation and elongation during chromosome replication
RY67_RS04370	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
RY67_RS04390	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
RY67_RS04435	COG1131	(ABC) transporter
RY67_RS04445	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
RY67_RS04480	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
RY67_RS04490	COG1937	Protein conserved in bacteria
RY67_RS04495	COG1322	Protein conserved in bacteria
RY67_RS04555	COG1609	Transcriptional regulator
RY67_RS04560	COG2211	Major facilitator Superfamily
RY67_RS04580	COG4974	Belongs to the 'phage' integrase family
RY67_RS04585	COG2801	Transposase and inactivated derivatives
RY67_RS04615	COG0745	RESPONSE REGULATOR receiver
RY67_RS04630	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
RY67_RS04670	COG0356	it plays a direct role in the translocation of protons across the membrane
RY67_RS04705	COG0355	proton-transporting ATP synthase activity, rotational mechanism
RY67_RS04715	COG0545	Peptidyl-prolyl cis-trans isomerase
RY67_RS04755	COG0251	oxidation-reduction process
RY67_RS04790	COG3842	ATPase activity
RY67_RS04805	COG1027	Aspartate ammonia-lyase
RY67_RS04820	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
RY67_RS04860	COG2270	Major facilitator Superfamily
RY67_RS04865	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
RY67_RS04865	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
RY67_RS04885	COG1301	dicarboxylic acid transport
RY67_RS04890	COG0742	ribosomal rna small subunit methyltransferase
RY67_RS04900	COG0826	peptidase U32
RY67_RS04905	COG1496	oxidoreductase activity
RY67_RS04915	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
RY67_RS04925	COG3579	cysteine-type endopeptidase activity
RY67_RS04930	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
RY67_RS04935	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
RY67_RS04940	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
RY67_RS04945	COG0477	Major facilitator Superfamily
RY67_RS04950	COG5002	protein histidine kinase activity
RY67_RS04955	COG0745	RESPONSE REGULATOR receiver
RY67_RS04980	COG1704	LemA family
RY67_RS05000	COG1957	nucleoside hydrolase
RY67_RS05015	COG1837	Belongs to the UPF0109 family
RY67_RS05045	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
RY67_RS05045	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
RY67_RS05075	COG0505	Belongs to the CarA family
RY67_RS05080	COG0488	(ABC) transporter
RY67_RS05085	COG1487	ribonuclease activity
RY67_RS05095	COG0440	acetolactate synthase activity
RY67_RS05135	COG0667	Aldo Keto reductase
RY67_RS05175	COG2348	transferase activity, transferring amino-acyl groups
RY67_RS05205	COG1116	anion transmembrane transporter activity
RY67_RS05225	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
RY67_RS05230	COG1609	Transcriptional regulator
RY67_RS05255	COG1132	(ABC) transporter
RY67_RS05260	COG2814	Major facilitator Superfamily
RY67_RS05285	COG1136	(ABC) transporter
RY67_RS05320	COG2197	response regulator
RY67_RS05325	COG4585	Histidine kinase
RY67_RS05330	COG1136	(ABC) transporter
RY67_RS05330	COG0577	efflux transmembrane transporter activity
RY67_RS05355	COG3867	Arabinogalactan endo-beta-1,4-galactanase
RY67_RS05370	COG0656	L-ascorbic acid biosynthetic process
RY67_RS05385	COG2814	Major facilitator Superfamily
RY67_RS05400	COG2826	transposase and inactivated derivatives, IS30 family
RY67_RS05440	COG2197	response regulator
RY67_RS05495	COG0577	efflux transmembrane transporter activity
RY67_RS05525	COG5002	protein histidine kinase activity
RY67_RS05530	COG1136	(ABC) transporter
RY67_RS05535	COG0577	efflux transmembrane transporter activity
RY67_RS05605	COG4974	Belongs to the 'phage' integrase family
RY67_RS05630	COG4585	Histidine kinase
RY67_RS05640	COG0577	efflux transmembrane transporter activity
RY67_RS05640	COG1136	(ABC) transporter
RY67_RS05645	COG1132	(ABC) transporter
RY67_RS05665	COG2197	response regulator
RY67_RS05670	COG4585	Histidine kinase
RY67_RS05700	COG2190	(PTS) system
RY67_RS05700	COG2211	Major facilitator Superfamily
RY67_RS05705	COG1131	(ABC) transporter
RY67_RS05745	COG1192	Involved in chromosome partitioning
RY67_RS05795	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
RY67_RS05800	COG1454	alcohol dehydrogenase
RY67_RS05805	COG1215	transferase activity, transferring glycosyl groups
RY67_RS05840	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
RY67_RS05845	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RY67_RS05855	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
RY67_RS05860	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
RY67_RS05870	COG1946	Acyl-CoA thioesterase
RY67_RS05895	COG3655	Transcriptional regulator
RY67_RS05910	COG4591	ABC-type transport system involved in lipoprotein release permease component
RY67_RS05910	COG1136	(ABC) transporter
RY67_RS05950	COG0242	peptide deformylase activity
RY67_RS05965	COG2814	Major facilitator Superfamily
RY67_RS05970	COG1070	Carbohydrate kinase
RY67_RS06025	COG0009	L-threonylcarbamoyladenylate synthase
RY67_RS06030	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
RY67_RS06045	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
RY67_RS06050	COG1355	regulation of microtubule-based process
RY67_RS06080	COG3590	peptidase
RY67_RS06140	COG0436	Aminotransferase
RY67_RS06170	COG1022	Amp-dependent synthetase and ligase
RY67_RS06175	COG2249	NAD(P)H dehydrogenase (quinone) activity
RY67_RS06185	COG1722	exodeoxyribonuclease VII activity
RY67_RS06190	COG1570	exodeoxyribonuclease VII activity
RY67_RS06195	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
RY67_RS06195	COG1328	CTP reductase activity
RY67_RS06200	COG0602	queuosine metabolic process
RY67_RS06235	COG1472	Belongs to the glycosyl hydrolase 3 family
RY67_RS06280	COG4251	negative regulation of phosphorylation
RY67_RS06280	COG5001	Diguanylate cyclase
RY67_RS06280	COG2203	Gaf domain
RY67_RS06280	COG3706	GGDEF domain
RY67_RS06285	COG1132	(ABC) transporter
RY67_RS06290	COG1132	(ABC) transporter
RY67_RS06305	COG0477	Major facilitator Superfamily
RY67_RS06315	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RY67_RS06320	COG1609	Transcriptional regulator
RY67_RS06325	COG2186	Transcriptional regulator
RY67_RS06335	COG1940	carbohydrate kinase activity
RY67_RS06340	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
RY67_RS06350	COG0747	negative chemotaxis
RY67_RS06360	COG0444	Belongs to the ABC transporter superfamily
RY67_RS06365	COG4608	Belongs to the ABC transporter superfamily
RY67_RS06370	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RY67_RS06375	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
RY67_RS06385	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
RY67_RS06400	COG3842	ATPase activity
RY67_RS06435	COG1609	Transcriptional regulator
RY67_RS06440	COG1609	Transcriptional regulator
RY67_RS06445	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
RY67_RS06450	COG3265	gluconokinase activity
RY67_RS06455	COG4948	Mandelate Racemase Muconate Lactonizing
RY67_RS06460	COG0246	Mannitol dehydrogenase
RY67_RS06465	COG1904	glucuronate isomerase
RY67_RS06480	COG2801	Transposase and inactivated derivatives
RY67_RS06535	COG1518	maintenance of DNA repeat elements
RY67_RS06540	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
RY67_RS06585	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
RY67_RS06640	COG0714	Associated with various cellular activities
RY67_RS06655	COG1278	Cold shock
RY67_RS06675	COG0745	RESPONSE REGULATOR receiver
RY67_RS06680	COG2205	protein histidine kinase activity
RY67_RS06685	COG1278	Cold shock
RY67_RS06695	COG0589	response to stress
RY67_RS06710	COG1196	nuclear chromosome segregation
RY67_RS06730	COG1126	abc transporter atp-binding protein
RY67_RS06735	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RY67_RS06740	COG0765	amino acid transport
RY67_RS06745	COG0765	amino acid transport
RY67_RS06755	COG2326	polyphosphate kinase activity
RY67_RS06760	COG4581	dead DEAH box helicase
RY67_RS06770	COG2814	Major facilitator Superfamily
RY67_RS06775	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
RY67_RS06820	COG1122	ATPase activity
RY67_RS06850	COG0390	transport system, permease component
RY67_RS06855	COG0577	efflux transmembrane transporter activity
RY67_RS06855	COG1136	(ABC) transporter
RY67_RS06880	COG0284	orotidine-5'-phosphate decarboxylase activity
RY67_RS06890	COG2176	DNA-directed DNA polymerase activity
RY67_RS06895	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
RY67_RS06910	COG0765	amino acid transport
RY67_RS06915	COG1126	abc transporter atp-binding protein
RY67_RS06920	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RY67_RS06925	COG0626	cystathionine gamma-synthase activity
RY67_RS06940	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
RY67_RS06955	COG0559	Belongs to the binding-protein-dependent transport system permease family
RY67_RS06965	COG1473	amidohydrolase
RY67_RS06975	COG1126	abc transporter atp-binding protein
RY67_RS06980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RY67_RS06985	COG0765	amino acid transport
RY67_RS07040	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
RY67_RS07080	COG3328	transposase activity
RY67_RS07105	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
RY67_RS07140	COG3480	Lon protease (S16) C-terminal proteolytic domain
RY67_RS07185	COG1957	nucleoside hydrolase
RY67_RS07195	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RY67_RS07235	COG0352	thiamine-phosphate diphosphorylase activity
RY67_RS07235	COG0351	phosphomethylpyrimidine kinase
RY67_RS07240	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RY67_RS07265	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
RY67_RS07295	COG1136	(ABC) transporter
RY67_RS07295	COG0577	efflux transmembrane transporter activity
RY67_RS07325	COG0587	DNA-directed DNA polymerase activity
RY67_RS07335	COG4716	Myosin-crossreactive antigen
RY67_RS07360	COG0656	L-ascorbic acid biosynthetic process
RY67_RS07405	COG0174	glutamine synthetase
RY67_RS07410	COG2814	Major facilitator Superfamily
RY67_RS07425	COG0747	negative chemotaxis
RY67_RS07440	COG1643	Atp-dependent helicase
RY67_RS07445	COG2813	Specifically methylates the guanine in position
RY67_RS07450	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
RY67_RS07480	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
RY67_RS07505	COG0768	penicillin binding
RY67_RS07515	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
RY67_RS07555	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
RY67_RS07590	COG1175	transmembrane transport
RY67_RS07595	COG0395	ABC-type sugar transport system, permease component
RY67_RS07605	COG1472	Belongs to the glycosyl hydrolase 3 family
RY67_RS07655	COG1940	carbohydrate kinase activity
RY67_RS07675	COG4166	transmembrane transport
RY67_RS07680	COG0601	transmembrane transport
RY67_RS07700	COG0006	proline dipeptidase activity
RY67_RS07710	COG0285	dihydrofolate synthase activity
RY67_RS07715	COG1196	nuclear chromosome segregation
RY67_RS07730	COG1595	DNA-templated transcription, initiation
RY67_RS07740	COG2017	converts alpha-aldose to the beta-anomer
RY67_RS07745	COG2017	converts alpha-aldose to the beta-anomer
RY67_RS07755	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
RY67_RS07775	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
RY67_RS07795	COG0577	efflux transmembrane transporter activity
RY67_RS07795	COG1136	(ABC) transporter
RY67_RS07805	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
RY67_RS07810	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
RY67_RS07820	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
RY67_RS07825	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
RY67_RS07835	COG1104	cysteine desulfurase activity
RY67_RS07840	COG1217	gtp-binding protein TYPA
RY67_RS07855	COG1605	Chorismate mutase
RY67_RS07855	COG0077	Prephenate dehydratase
RY67_RS07860	COG0287	Prephenate dehydrogenase
RY67_RS07875	COG4166	transmembrane transport
RY67_RS07880	COG0601	transmembrane transport
RY67_RS07885	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RY67_RS07895	COG0708	Exodeoxyribonuclease III
RY67_RS07950	COG0670	Belongs to the BI1 family
RY67_RS07960	COG2357	RelA SpoT domain protein
RY67_RS07965	COG3328	transposase activity
RY67_RS07985	COG0488	(ABC) transporter
RY67_RS07990	COG2826	transposase and inactivated derivatives, IS30 family
RY67_RS07995	COG3547	Transposase (IS116 IS110 IS902 family)
RY67_RS08030	COG1396	sequence-specific DNA binding
RY67_RS08055	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
RY67_RS08070	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
RY67_RS08090	COG0142	geranyltranstransferase activity
RY67_RS08100	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
RY67_RS08105	COG0187	DNA topoisomerase II activity
RY67_RS08115	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RY67_RS08120	COG1201	RNA secondary structure unwinding
RY67_RS08130	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
RY67_RS08155	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
RY67_RS08160	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
RY67_RS08185	COG2801	Transposase and inactivated derivatives
RY67_RS08260	COG1136	(ABC) transporter
RY67_RS08260	COG0577	efflux transmembrane transporter activity
RY67_RS08275	COG1131	(ABC) transporter
RY67_RS08325	COG0406	alpha-ribazole phosphatase activity
RY67_RS08330	COG0598	Magnesium transport protein CorA
RY67_RS08335	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RY67_RS08345	COG1596	polysaccharide export
RY67_RS08345	COG1555	photosystem II stabilization
RY67_RS08360	COG0802	atpase or kinase
RY67_RS08370	COG0456	acetyltransferase
RY67_RS08415	COG2826	transposase and inactivated derivatives, IS30 family
RY67_RS08500	COG4585	Histidine kinase
RY67_RS08505	COG2197	response regulator
RY67_RS08535	COG0516	GMP reductase activity
RY67_RS08575	COG0575	Belongs to the CDS family
RY67_RS08605	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
RY67_RS08620	COG0488	(ABC) transporter
RY67_RS08625	COG4221	oxidoreductase activity
RY67_RS08650	COG2205	protein histidine kinase activity
RY67_RS08655	COG0745	RESPONSE REGULATOR receiver
RY67_RS08670	COG1136	(ABC) transporter
RY67_RS08670	COG0577	efflux transmembrane transporter activity
RY67_RS08675	COG1136	(ABC) transporter
RY67_RS08675	COG0577	efflux transmembrane transporter activity
RY67_RS08715	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
RY67_RS08740	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
RY67_RS08755	COG0436	Aminotransferase
RY67_RS08770	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
RY67_RS08870	COG0045	succinate-CoA ligase (ADP-forming) activity
RY67_RS08895	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
RY67_RS08900	COG1187	pseudouridine synthase activity
RY67_RS08945	COG4974	Belongs to the 'phage' integrase family
RY67_RS08985	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
RY67_RS09045	COG1136	(ABC) transporter
RY67_RS09065	COG1716	ATPase activity
RY67_RS09085	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
RY67_RS09100	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
RY67_RS09115	COG0133	tryptophan synthase activity
RY67_RS09120	COG2135	peptidase activity
RY67_RS09130	COG0833	amino acid
RY67_RS09240	COG0833	amino acid
RY67_RS09250	COG3189	MarR family transcriptional regulator
RY67_RS09285	COG3189	MarR family transcriptional regulator
RY67_RS09315	COG0583	DNA-binding transcription factor activity
RY67_RS09335	COG0167	dihydroorotate dehydrogenase activity
RY67_RS09345	COG0284	orotidine-5'-phosphate decarboxylase activity
RY67_RS09350	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
RY67_RS09375	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
RY67_RS09400	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
RY67_RS09470	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
RY67_RS09475	COG3328	transposase activity
RY67_RS09495	COG3328	transposase activity
RY67_RS09505	COG1119	ATPase activity
RY67_RS09510	COG0297	glycogen (starch) synthase activity
RY67_RS09525	COG4166	transmembrane transport
RY67_RS09535	COG0069	glutamate synthase activity
RY67_RS09535	COG0070	glutamate synthase
RY67_RS09535	COG0067	glutamate synthase
RY67_RS09540	COG1609	Transcriptional regulator
RY67_RS09565	COG2860	membrane
RY67_RS09570	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
RY67_RS09595	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
RY67_RS09620	COG1702	phosphate starvation-inducible protein PhoH
RY67_RS09625	COG0537	adenosine 5'-monophosphoramidase activity
RY67_RS09630	COG1385	rRNA (uridine-N3-)-methyltransferase activity
RY67_RS09650	COG2151	metal-sulfur cluster biosynthetic enzyme
RY67_RS09660	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
RY67_RS09665	COG0396	ATPase activity
RY67_RS09670	COG0719	Fe-S assembly protein
RY67_RS09685	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
RY67_RS09765	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
RY67_RS09775	COG1136	(ABC) transporter
RY67_RS09775	COG0577	efflux transmembrane transporter activity
RY67_RS09805	COG3655	Transcriptional regulator
RY67_RS09830	COG1335	isochorismatase
RY67_RS09835	COG3340	Belongs to the peptidase S51 family
RY67_RS09860	COG2197	response regulator
RY67_RS09900	COG1131	(ABC) transporter
RY67_RS09905	COG4585	Histidine kinase
RY67_RS09910	COG2197	response regulator
RY67_RS09935	COG0477	Major facilitator Superfamily
RY67_RS09940	COG0513	Belongs to the DEAD box helicase family
RY67_RS09945	COG2233	PERMEase
RY67_RS09985	COG2815	serine threonine protein kinase
RY67_RS09985	COG0515	serine threonine protein kinase
RY67_RS09995	COG2814	Major facilitator Superfamily
RY67_RS10010	COG1309	transcriptional regulator
RY67_RS10050	COG3177	Filamentation induced by cAMP protein fic
RY67_RS10060	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
RY67_RS10075	COG0012	GTP binding
RY67_RS10080	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
RY67_RS10095	COG2197	response regulator
RY67_RS10100	COG0577	efflux transmembrane transporter activity
RY67_RS10100	COG1136	(ABC) transporter
RY67_RS10105	COG1136	(ABC) transporter
RY67_RS10110	COG2873	o-acetylhomoserine
RY67_RS10130	COG0758	DNA mediated transformation
RY67_RS10135	COG1053	succinate dehydrogenase
RY67_RS10150	COG1611	Belongs to the LOG family
RY67_RS10210	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
RY67_RS10215	COG1882	Formate acetyltransferase
RY67_RS10230	COG1473	amidohydrolase
RY67_RS10235	COG2011	ABC-type metal ion transport system permease component
RY67_RS10275	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
RY67_RS10275	COG2755	lipolytic protein G-D-S-L family
RY67_RS10295	COG0799	negative regulation of ribosome biogenesis
RY67_RS10300	COG0406	alpha-ribazole phosphatase activity
RY67_RS10315	COG0857	belongs to the CobB CobQ family
RY67_RS10315	COG0280	phosphate acetyltransferase
RY67_RS10320	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
RY67_RS10350	COG1051	belongs to the nudix hydrolase family
RY67_RS10355	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
RY67_RS10375	COG0469	pyruvate kinase activity
RY67_RS10395	COG2197	response regulator
RY67_RS10405	COG0577	efflux transmembrane transporter activity
RY67_RS10405	COG1136	(ABC) transporter
RY67_RS10415	COG0539	negative regulation of cytoplasmic translation
RY67_RS10425	COG0803	Belongs to the bacterial solute-binding protein 9 family
RY67_RS10430	COG1121	(ABC) transporter
RY67_RS10445	COG1329	Transcriptional regulator
RY67_RS10455	COG0745	RESPONSE REGULATOR receiver
RY67_RS10460	COG2205	protein histidine kinase activity
RY67_RS10470	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
RY67_RS10505	COG1316	TRANSCRIPTIONal
RY67_RS10530	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
RY67_RS10540	COG1760	l-serine dehydratase
RY67_RS10580	COG4555	ABC transporter
RY67_RS10625	COG0667	Aldo Keto reductase
RY67_RS10650	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
RY67_RS10650	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RY67_RS10665	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
RY67_RS10710	COG1131	(ABC) transporter
RY67_RS10720	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RY67_RS10725	COG0497	DNA recombination
RY67_RS10770	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
RY67_RS10775	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
RY67_RS10845	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RY67_RS10855	COG1122	ATPase activity
RY67_RS10860	COG4721	ABC-type cobalt transport system, permease component
RY67_RS10865	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RY67_RS10890	COG3250	beta-galactosidase activity
RY67_RS10900	COG0110	maltose O-acetyltransferase activity
RY67_RS10920	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
RY67_RS10965	COG1063	alcohol dehydrogenase
RY67_RS10995	COG0583	DNA-binding transcription factor activity
RY67_RS11055	COG0385	Bile acid
RY67_RS11075	COG0436	Aminotransferase
RY67_RS11095	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL