locus-tag	class	description
HUE59_RS00025	COG1051	belongs to the nudix hydrolase family
HUE59_RS00030	COG0706	membrane insertase activity
HUE59_RS00045	COG0833	amino acid
HUE59_RS00055	COG3189	MarR family transcriptional regulator
HUE59_RS00085	COG3189	MarR family transcriptional regulator
HUE59_RS00110	COG0583	DNA-binding transcription factor activity
HUE59_RS00130	COG0167	dihydroorotate dehydrogenase activity
HUE59_RS00140	COG0284	orotidine-5'-phosphate decarboxylase activity
HUE59_RS00145	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HUE59_RS00170	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HUE59_RS00260	COG4221	oxidoreductase activity
HUE59_RS00280	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HUE59_RS00290	COG0561	phosphatase activity
HUE59_RS00290	COG0561	phosphatase activity
HUE59_RS00295	COG1119	ATPase activity
HUE59_RS00300	COG0297	glycogen (starch) synthase activity
HUE59_RS00315	COG4166	transmembrane transport
HUE59_RS00325	COG0069	glutamate synthase activity
HUE59_RS00325	COG0070	glutamate synthase
HUE59_RS00325	COG0067	glutamate synthase
HUE59_RS00330	COG1609	Transcriptional regulator
HUE59_RS00335	COG1929	Belongs to the glycerate kinase type-1 family
HUE59_RS00355	COG2860	membrane
HUE59_RS00365	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HUE59_RS00390	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HUE59_RS00415	COG1702	phosphate starvation-inducible protein PhoH
HUE59_RS00420	COG0537	adenosine 5'-monophosphoramidase activity
HUE59_RS00425	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HUE59_RS00445	COG2151	metal-sulfur cluster biosynthetic enzyme
HUE59_RS00455	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HUE59_RS00460	COG0396	ATPase activity
HUE59_RS00465	COG0719	Fe-S assembly protein
HUE59_RS00480	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HUE59_RS00560	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HUE59_RS00570	COG0577	efflux transmembrane transporter activity
HUE59_RS00570	COG1136	(ABC) transporter
HUE59_RS00600	COG3655	Transcriptional regulator
HUE59_RS00625	COG1335	isochorismatase
HUE59_RS00630	COG3340	Belongs to the peptidase S51 family
HUE59_RS00675	COG1131	(ABC) transporter
HUE59_RS00680	COG4585	Histidine kinase
HUE59_RS00685	COG2197	response regulator
HUE59_RS00695	COG0306	phosphate transporter
HUE59_RS00700	COG0366	Alpha amylase catalytic
HUE59_RS00715	COG0513	Belongs to the DEAD box helicase family
HUE59_RS00720	COG2233	PERMEase
HUE59_RS00790	COG2815	serine threonine protein kinase
HUE59_RS00790	COG0515	serine threonine protein kinase
HUE59_RS00800	COG2814	Major facilitator Superfamily
HUE59_RS00805	COG1309	transcriptional regulator
HUE59_RS00850	COG3177	Filamentation induced by cAMP protein fic
HUE59_RS00880	COG0012	GTP binding
HUE59_RS00885	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HUE59_RS00900	COG2197	response regulator
HUE59_RS00905	COG0577	efflux transmembrane transporter activity
HUE59_RS00905	COG1136	(ABC) transporter
HUE59_RS00910	COG1136	(ABC) transporter
HUE59_RS00915	COG2873	o-acetylhomoserine
HUE59_RS00935	COG0758	DNA mediated transformation
HUE59_RS00940	COG1053	succinate dehydrogenase
HUE59_RS00955	COG1611	Belongs to the LOG family
HUE59_RS01015	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HUE59_RS01020	COG1882	Formate acetyltransferase
HUE59_RS01035	COG1473	amidohydrolase
HUE59_RS01040	COG2011	ABC-type metal ion transport system permease component
HUE59_RS01070	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HUE59_RS01070	COG2755	lipolytic protein G-D-S-L family
HUE59_RS01090	COG0799	negative regulation of ribosome biogenesis
HUE59_RS01095	COG0406	alpha-ribazole phosphatase activity
HUE59_RS01110	COG0280	phosphate acetyltransferase
HUE59_RS01110	COG0857	belongs to the CobB CobQ family
HUE59_RS01115	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HUE59_RS01140	COG0519	Catalyzes the synthesis of GMP from XMP
HUE59_RS01165	COG1051	belongs to the nudix hydrolase family
HUE59_RS01170	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HUE59_RS01190	COG0469	pyruvate kinase activity
HUE59_RS01210	COG2197	response regulator
HUE59_RS01225	COG0577	efflux transmembrane transporter activity
HUE59_RS01225	COG1136	(ABC) transporter
HUE59_RS01235	COG0539	negative regulation of cytoplasmic translation
HUE59_RS01245	COG0803	Belongs to the bacterial solute-binding protein 9 family
HUE59_RS01250	COG1121	(ABC) transporter
HUE59_RS01265	COG1329	Transcriptional regulator
HUE59_RS01275	COG0745	RESPONSE REGULATOR receiver
HUE59_RS01280	COG2205	protein histidine kinase activity
HUE59_RS01290	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HUE59_RS01320	COG1316	TRANSCRIPTIONal
HUE59_RS01345	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HUE59_RS01355	COG1760	l-serine dehydratase
HUE59_RS01390	COG0667	Aldo Keto reductase
HUE59_RS01430	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HUE59_RS01460	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HUE59_RS01500	COG2814	Major facilitator Superfamily
HUE59_RS01505	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HUE59_RS01510	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HUE59_RS01515	COG0497	DNA recombination
HUE59_RS01540	COG0647	UMP catabolic process
HUE59_RS01565	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HUE59_RS01570	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HUE59_RS01640	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HUE59_RS01650	COG1122	ATPase activity
HUE59_RS01655	COG4721	ABC-type cobalt transport system, permease component
HUE59_RS01660	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HUE59_RS01715	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HUE59_RS01775	COG2801	Transposase and inactivated derivatives
HUE59_RS01785	COG1063	alcohol dehydrogenase
HUE59_RS01810	COG0583	DNA-binding transcription factor activity
HUE59_RS01875	COG0385	Bile acid
HUE59_RS01895	COG0436	Aminotransferase
HUE59_RS01915	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HUE59_RS01955	COG0667	Aldo Keto reductase
HUE59_RS01965	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HUE59_RS01970	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HUE59_RS01975	COG0402	S-adenosylhomocysteine deaminase activity
HUE59_RS01985	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUE59_RS02015	COG1012	belongs to the aldehyde dehydrogenase family
HUE59_RS02035	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HUE59_RS02040	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HUE59_RS02045	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HUE59_RS02055	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HUE59_RS02070	COG0701	Predicted permease
HUE59_RS02115	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HUE59_RS02120	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HUE59_RS02130	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HUE59_RS02135	COG0577	efflux transmembrane transporter activity
HUE59_RS02135	COG0577	efflux transmembrane transporter activity
HUE59_RS02145	COG0577	efflux transmembrane transporter activity
HUE59_RS02145	COG1136	(ABC) transporter
HUE59_RS02160	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HUE59_RS02180	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HUE59_RS02195	COG0358	DNA primase activity
HUE59_RS02205	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HUE59_RS02210	COG0531	amino acid
HUE59_RS02225	COG0514	ATP-dependent DNA helicase (RecQ)
HUE59_RS02235	COG0626	cystathionine gamma-synthase activity
HUE59_RS02260	COG4608	Belongs to the ABC transporter superfamily
HUE59_RS02280	COG0747	negative chemotaxis
HUE59_RS02285	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HUE59_RS02310	COG0564	pseudouridine synthase activity
HUE59_RS02345	COG3942	CHAP domain
HUE59_RS02345	COG1388	LysM domain
HUE59_RS02350	COG2177	Part of the ABC transporter FtsEX involved in
HUE59_RS02355	COG2884	Cell division ATP-binding protein ftsE
HUE59_RS02360	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HUE59_RS02385	COG1175	transmembrane transport
HUE59_RS02390	COG0395	ABC-type sugar transport system, permease component
HUE59_RS02395	COG1653	transport
HUE59_RS02410	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HUE59_RS02430	COG0210	DNA helicase
HUE59_RS02450	COG0714	Associated with various cellular activities
HUE59_RS02500	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HUE59_RS02520	COG2814	Major facilitator Superfamily
HUE59_RS02530	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUE59_RS02550	COG0477	Major facilitator Superfamily
HUE59_RS02565	COG0477	Major facilitator Superfamily
HUE59_RS02570	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HUE59_RS02580	COG1349	DNA-binding transcription factor activity
HUE59_RS02585	COG0167	dihydroorotate dehydrogenase activity
HUE59_RS02590	COG1902	pentaerythritol trinitrate reductase activity
HUE59_RS02595	COG4499	WXG100 protein secretion system (Wss), protein YukC
HUE59_RS02595	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HUE59_RS02605	COG0095	Lipoate-protein ligase
HUE59_RS02680	COG1484	DNA-dependent DNA replication
HUE59_RS02690	COG0489	protein tyrosine kinase activity
HUE59_RS02705	COG0758	DNA mediated transformation
HUE59_RS02740	COG1088	dTDP-glucose 4,6-dehydratase activity
HUE59_RS02745	COG0438	transferase activity, transferring glycosyl groups
HUE59_RS02750	COG0297	glycogen (starch) synthase activity
HUE59_RS02765	COG0438	transferase activity, transferring glycosyl groups
HUE59_RS02775	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HUE59_RS02790	COG4641	Protein conserved in bacteria
HUE59_RS02790	COG0438	transferase activity, transferring glycosyl groups
HUE59_RS02835	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HUE59_RS02905	COG4122	O-methyltransferase activity
HUE59_RS02915	COG0586	Pfam SNARE associated Golgi protein
HUE59_RS02920	COG0560	Phosphoserine phosphatase
HUE59_RS02925	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HUE59_RS02955	COG0577	efflux transmembrane transporter activity
HUE59_RS02970	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HUE59_RS02990	COG0589	response to stress
HUE59_RS02995	COG0791	NLP P60 protein
HUE59_RS03005	COG3942	CHAP domain
HUE59_RS03005	COG1705	Flagellar rod assembly protein muramidase FlgJ
HUE59_RS03010	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HUE59_RS03020	COG5002	protein histidine kinase activity
HUE59_RS03025	COG0704	Plays a role in the regulation of phosphate uptake
HUE59_RS03055	COG1575	Belongs to the MenA family. Type 1 subfamily
HUE59_RS03085	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HUE59_RS03095	COG2814	Major facilitator Superfamily
HUE59_RS03135	COG2197	response regulator
HUE59_RS03170	COG1803	Methylglyoxal synthase
HUE59_RS03170	COG1597	lipid kinase activity
HUE59_RS03200	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HUE59_RS03210	COG0328	RNA-DNA hybrid ribonuclease activity
HUE59_RS03235	COG0196	riboflavin kinase activity
HUE59_RS03275	COG0395	ABC-type sugar transport system, permease component
HUE59_RS03280	COG1175	transmembrane transport
HUE59_RS03305	COG2308	Evidence 4 Homologs of previously reported genes of
HUE59_RS03410	COG0255	Belongs to the universal ribosomal protein uL29 family
HUE59_RS03460	COG3527	Alpha-acetolactate decarboxylase
HUE59_RS03470	COG1454	alcohol dehydrogenase
HUE59_RS03470	COG1012	belongs to the aldehyde dehydrogenase family
HUE59_RS03505	COG1739	Uncharacterized protein family UPF0029
HUE59_RS03510	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HUE59_RS03520	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HUE59_RS03535	COG0531	amino acid
HUE59_RS03540	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HUE59_RS03565	COG0626	cystathionine gamma-synthase activity
HUE59_RS03630	COG2252	PERMEase
HUE59_RS03645	COG1132	(ABC) transporter
HUE59_RS03650	COG1122	ATPase activity
HUE59_RS03710	COG2176	DNA-directed DNA polymerase activity
HUE59_RS03775	COG1175	transmembrane transport
HUE59_RS03780	COG0395	ABC-type sugar transport system, permease component
HUE59_RS03785	COG1621	beta-fructofuranosidase activity
HUE59_RS03795	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HUE59_RS03800	COG4770	biotin carboxylase activity
HUE59_RS03830	COG3959	Transketolase, thiamine diphosphate binding domain
HUE59_RS03835	COG0574	Belongs to the PEP-utilizing enzyme family
HUE59_RS03835	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HUE59_RS03840	COG2814	Major facilitator Superfamily
HUE59_RS03850	COG2814	Major facilitator Superfamily
HUE59_RS03855	COG1082	Xylose isomerase domain protein TIM barrel
HUE59_RS03860	COG0673	inositol 2-dehydrogenase activity
HUE59_RS03865	COG0673	inositol 2-dehydrogenase activity
HUE59_RS03870	COG1917	Cupin 2, conserved barrel domain protein
HUE59_RS03870	COG4977	sequence-specific DNA binding
HUE59_RS03880	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HUE59_RS03890	COG1414	Transcriptional regulator
HUE59_RS03945	COG0250	Participates in transcription elongation, termination and antitermination
HUE59_RS03950	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HUE59_RS03960	COG0436	Aminotransferase
HUE59_RS03985	COG1530	ribonuclease E activity
HUE59_RS03990	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HUE59_RS04000	COG4154	Belongs to the RbsD FucU family
HUE59_RS04020	COG4948	Mandelate Racemase Muconate Lactonizing
HUE59_RS04025	COG1609	Transcriptional regulator
HUE59_RS04035	COG1136	(ABC) transporter
HUE59_RS04050	COG0083	homoserine kinase activity
HUE59_RS04055	COG0460	homoserine dehydrogenase
HUE59_RS04100	COG1309	transcriptional regulator
HUE59_RS04110	COG0583	DNA-binding transcription factor activity
HUE59_RS04120	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HUE59_RS04125	COG0446	pyridine nucleotide-disulphide oxidoreductase
HUE59_RS04130	COG0167	dihydroorotate dehydrogenase activity
HUE59_RS04155	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HUE59_RS04160	COG0406	alpha-ribazole phosphatase activity
HUE59_RS04160	COG0494	nUDIX hydrolase
HUE59_RS04180	COG3250	beta-galactosidase activity
HUE59_RS04195	COG4154	Belongs to the RbsD FucU family
HUE59_RS04200	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HUE59_RS04210	COG4948	Mandelate Racemase Muconate Lactonizing
HUE59_RS04220	COG0395	ABC-type sugar transport system, permease component
HUE59_RS04225	COG4209	transmembrane transport
HUE59_RS04240	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HUE59_RS04280	COG0395	ABC-type sugar transport system, permease component
HUE59_RS04290	COG3842	ATPase activity
HUE59_RS04340	COG0395	ABC-type sugar transport system, permease component
HUE59_RS04345	COG1175	transmembrane transport
HUE59_RS04350	COG0584	glycerophosphoryl diester phosphodiesterase
HUE59_RS04370	COG0179	Fumarylacetoacetate (FAA) hydrolase
HUE59_RS04395	COG0395	ABC-type sugar transport system, permease component
HUE59_RS04400	COG1175	transmembrane transport
HUE59_RS04425	COG0463	Glycosyl transferase, family 2
HUE59_RS04435	COG1216	Glycosyl transferase, family 2
HUE59_RS04450	COG1216	Glycosyl transferase, family 2
HUE59_RS04460	COG1216	Glycosyl transferase, family 2
HUE59_RS04465	COG1088	dTDP-glucose 4,6-dehydratase activity
HUE59_RS04485	COG1129	ABC transporter
HUE59_RS04505	COG0084	hydrolase, TatD family'
HUE59_RS04520	COG0477	Major facilitator Superfamily
HUE59_RS04530	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
HUE59_RS04540	COG3177	Filamentation induced by cAMP protein fic
HUE59_RS04550	COG1132	(ABC) transporter
HUE59_RS04555	COG1132	(ABC) transporter
HUE59_RS04585	COG4166	transmembrane transport
HUE59_RS04650	COG1132	(ABC) transporter
HUE59_RS04660	COG1846	Transcriptional regulator
HUE59_RS04665	COG1113	amino acid transport
HUE59_RS04680	COG1113	amino acid transport
HUE59_RS04710	COG0588	phosphoglycerate mutase activity
HUE59_RS04720	COG0778	Nitroreductase
HUE59_RS04755	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HUE59_RS04760	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HUE59_RS04765	COG0366	Alpha amylase catalytic
HUE59_RS04770	COG0395	ABC-type sugar transport system, permease component
HUE59_RS04775	COG1175	transmembrane transport
HUE59_RS04795	COG0590	tRNA wobble adenosine to inosine editing
HUE59_RS04795	COG0037	tRNA processing
HUE59_RS04800	COG0025	NhaP-type Na H and K H
HUE59_RS04830	COG3833	ABC-type maltose transport systems, permease component
HUE59_RS04835	COG1175	transmembrane transport
HUE59_RS04840	COG1653	transport
HUE59_RS04845	COG1486	melibiose metabolic process
HUE59_RS04850	COG1349	DNA-binding transcription factor activity
HUE59_RS04880	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HUE59_RS04890	COG1263	PTS System
HUE59_RS04890	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HUE59_RS04890	COG2190	(PTS) system
HUE59_RS04895	COG1263	PTS System
HUE59_RS04895	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HUE59_RS04905	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HUE59_RS04915	COG3842	ATPase activity
HUE59_RS04920	COG1215	transferase activity, transferring glycosyl groups
HUE59_RS04930	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HUE59_RS04955	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HUE59_RS04980	COG3583	domain protein
HUE59_RS05000	COG0617	tRNA 3'-terminal CCA addition
HUE59_RS05025	COG1475	DNA binding
HUE59_RS05030	COG1192	Involved in chromosome partitioning
HUE59_RS05070	COG0592	DNA-directed DNA polymerase activity
HUE59_RS05085	COG0187	DNA topoisomerase II activity
HUE59_RS05090	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HUE59_RS05095	COG3266	domain, Protein
HUE59_RS05100	COG0542	response to heat
HUE59_RS05110	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HUE59_RS05160	COG3639	organic phosphonate transmembrane transporter activity
HUE59_RS05175	COG1737	Transcriptional regulator
HUE59_RS05200	COG0783	Belongs to the Dps family
HUE59_RS05205	COG1253	flavin adenine dinucleotide binding
HUE59_RS05215	COG0842	Transport permease protein
HUE59_RS05215	COG1131	(ABC) transporter
HUE59_RS05215	COG1716	ATPase activity
HUE59_RS05220	COG1716	ATPase activity
HUE59_RS05220	COG1131	(ABC) transporter
HUE59_RS05220	COG0842	Transport permease protein
HUE59_RS05255	COG1373	ATPase (AAA superfamily
HUE59_RS05270	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HUE59_RS05290	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HUE59_RS05305	COG0180	Tryptophanyl-tRNA synthetase
HUE59_RS05315	COG2197	response regulator
HUE59_RS05335	COG0058	SHG alpha-glucan phosphorylase activity
HUE59_RS05375	COG0515	serine threonine protein kinase
HUE59_RS05380	COG0768	penicillin binding
HUE59_RS05425	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HUE59_RS05430	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HUE59_RS05430	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HUE59_RS05460	COG0071	Belongs to the small heat shock protein (HSP20) family
HUE59_RS05500	COG0343	queuine tRNA-ribosyltransferase activity
HUE59_RS05520	COG0559	Belongs to the binding-protein-dependent transport system permease family
HUE59_RS05540	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HUE59_RS05550	COG0804	urea catabolic process
HUE59_RS05565	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HUE59_RS05610	COG2226	methyltransferase
HUE59_RS05615	COG4974	Belongs to the 'phage' integrase family
HUE59_RS05630	COG2188	Transcriptional regulator
HUE59_RS05635	COG1397	ADP-ribosylglycohydrolase
HUE59_RS05640	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HUE59_RS05640	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HUE59_RS05665	COG0191	fructose-bisphosphate aldolase activity
HUE59_RS05715	COG0477	Major facilitator Superfamily
HUE59_RS05735	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HUE59_RS05740	COG1122	ATPase activity
HUE59_RS05745	COG1268	BioY protein
HUE59_RS05810	COG0789	Transcriptional regulator
HUE59_RS05835	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HUE59_RS05840	COG0586	Pfam SNARE associated Golgi protein
HUE59_RS05915	COG0527	aspartate kinase activity
HUE59_RS05955	COG1754	DNA topoisomerase type I activity
HUE59_RS05955	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HUE59_RS05985	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HUE59_RS06035	COG3152	Membrane
HUE59_RS06060	COG3619	membrane
HUE59_RS06080	COG0672	)-iron permease
HUE59_RS06085	COG3470	protein probably involved in high-affinity Fe2 transport
HUE59_RS06100	COG0577	efflux transmembrane transporter activity
HUE59_RS06105	COG1136	(ABC) transporter
HUE59_RS06135	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HUE59_RS06140	COG0363	glucosamine-6-phosphate deaminase activity
HUE59_RS06175	COG1216	Glycosyl transferase, family 2
HUE59_RS06180	COG1309	transcriptional regulator
HUE59_RS06205	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HUE59_RS06215	COG0305	Participates in initiation and elongation during chromosome replication
HUE59_RS06220	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HUE59_RS06240	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HUE59_RS06285	COG1131	(ABC) transporter
HUE59_RS06295	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HUE59_RS06335	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HUE59_RS06345	COG1937	Protein conserved in bacteria
HUE59_RS06350	COG1322	Protein conserved in bacteria
HUE59_RS06435	COG0745	RESPONSE REGULATOR receiver
HUE59_RS06450	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HUE59_RS06500	COG0582	viral genome integration into host DNA
HUE59_RS06580	COG0356	it plays a direct role in the translocation of protons across the membrane
HUE59_RS06615	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HUE59_RS06625	COG0545	Peptidyl-prolyl cis-trans isomerase
HUE59_RS06675	COG0251	oxidation-reduction process
HUE59_RS06710	COG3842	ATPase activity
HUE59_RS06725	COG1027	Aspartate ammonia-lyase
HUE59_RS06740	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HUE59_RS06790	COG2270	Major facilitator Superfamily
HUE59_RS06795	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HUE59_RS06795	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HUE59_RS06825	COG1301	dicarboxylic acid transport
HUE59_RS06830	COG0742	ribosomal rna small subunit methyltransferase
HUE59_RS06840	COG0826	peptidase U32
HUE59_RS06845	COG1496	oxidoreductase activity
HUE59_RS06855	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HUE59_RS06865	COG3579	cysteine-type endopeptidase activity
HUE59_RS06870	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HUE59_RS06875	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HUE59_RS06880	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HUE59_RS06885	COG0477	Major facilitator Superfamily
HUE59_RS06890	COG5002	protein histidine kinase activity
HUE59_RS06895	COG0745	RESPONSE REGULATOR receiver
HUE59_RS06920	COG1704	LemA family
HUE59_RS06945	COG1957	nucleoside hydrolase
HUE59_RS06970	COG1837	Belongs to the UPF0109 family
HUE59_RS07000	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HUE59_RS07000	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HUE59_RS07030	COG0505	Belongs to the CarA family
HUE59_RS07050	COG1487	ribonuclease activity
HUE59_RS07060	COG0440	acetolactate synthase activity
HUE59_RS07100	COG0667	Aldo Keto reductase
HUE59_RS07145	COG2348	transferase activity, transferring amino-acyl groups
HUE59_RS07175	COG1116	anion transmembrane transporter activity
HUE59_RS07195	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HUE59_RS07200	COG1609	Transcriptional regulator
HUE59_RS07235	COG2814	Major facilitator Superfamily
HUE59_RS07260	COG1136	(ABC) transporter
HUE59_RS07310	COG2814	Major facilitator Superfamily
HUE59_RS07390	COG0577	efflux transmembrane transporter activity
HUE59_RS07445	COG5002	protein histidine kinase activity
HUE59_RS07450	COG1136	(ABC) transporter
HUE59_RS07455	COG0577	efflux transmembrane transporter activity
HUE59_RS07495	COG4974	Belongs to the 'phage' integrase family
HUE59_RS07520	COG4585	Histidine kinase
HUE59_RS07530	COG1136	(ABC) transporter
HUE59_RS07530	COG0577	efflux transmembrane transporter activity
HUE59_RS07535	COG1132	(ABC) transporter
HUE59_RS07545	COG1131	(ABC) transporter
HUE59_RS07585	COG4585	Histidine kinase
HUE59_RS07610	COG1505	serine-type exopeptidase activity
HUE59_RS07620	COG2197	response regulator
HUE59_RS07625	COG4585	Histidine kinase
HUE59_RS07730	COG1131	(ABC) transporter
HUE59_RS07775	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HUE59_RS07815	COG1192	Involved in chromosome partitioning
HUE59_RS07850	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HUE59_RS07865	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HUE59_RS07870	COG1454	alcohol dehydrogenase
HUE59_RS07910	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HUE59_RS07915	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HUE59_RS07925	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HUE59_RS07930	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HUE59_RS07940	COG1946	Acyl-CoA thioesterase
HUE59_RS07985	COG4591	ABC-type transport system involved in lipoprotein release permease component
HUE59_RS07985	COG1136	(ABC) transporter
HUE59_RS07990	COG1136	(ABC) transporter
HUE59_RS07990	COG0577	efflux transmembrane transporter activity
HUE59_RS08010	COG1940	carbohydrate kinase activity
HUE59_RS08025	COG0242	peptide deformylase activity
HUE59_RS08035	COG2814	Major facilitator Superfamily
HUE59_RS08040	COG2814	Major facilitator Superfamily
HUE59_RS08050	COG1979	alcohol dehydrogenase
HUE59_RS08055	COG1609	Transcriptional regulator
HUE59_RS08070	COG0395	ABC-type sugar transport system, permease component
HUE59_RS08075	COG3507	Belongs to the glycosyl hydrolase 43 family
HUE59_RS08080	COG3507	Belongs to the glycosyl hydrolase 43 family
HUE59_RS08085	COG0110	maltose O-acetyltransferase activity
HUE59_RS08100	COG4213	ABC transporter substrate-binding protein
HUE59_RS08105	COG1129	ABC transporter
HUE59_RS08110	COG4214	carbohydrate transport
HUE59_RS08125	COG1070	Carbohydrate kinase
HUE59_RS08180	COG0009	L-threonylcarbamoyladenylate synthase
HUE59_RS08185	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HUE59_RS08200	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HUE59_RS08240	COG3590	peptidase
HUE59_RS08295	COG0436	Aminotransferase
HUE59_RS08325	COG1022	Amp-dependent synthetase and ligase
HUE59_RS08330	COG2249	NAD(P)H dehydrogenase (quinone) activity
HUE59_RS08340	COG1722	exodeoxyribonuclease VII activity
HUE59_RS08345	COG1570	exodeoxyribonuclease VII activity
HUE59_RS08350	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HUE59_RS08350	COG1328	CTP reductase activity
HUE59_RS08355	COG0602	queuosine metabolic process
HUE59_RS08450	COG5001	Diguanylate cyclase
HUE59_RS08450	COG4251	negative regulation of phosphorylation
HUE59_RS08450	COG3706	GGDEF domain
HUE59_RS08450	COG2203	Gaf domain
HUE59_RS08460	COG1132	(ABC) transporter
HUE59_RS08465	COG1132	(ABC) transporter
HUE59_RS08485	COG3069	C4-dicarboxylate transmembrane transporter activity
HUE59_RS08490	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HUE59_RS08495	COG1609	Transcriptional regulator
HUE59_RS08500	COG2186	Transcriptional regulator
HUE59_RS08510	COG1940	carbohydrate kinase activity
HUE59_RS08515	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
HUE59_RS08525	COG0747	negative chemotaxis
HUE59_RS08535	COG0444	Belongs to the ABC transporter superfamily
HUE59_RS08540	COG4608	Belongs to the ABC transporter superfamily
HUE59_RS08545	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HUE59_RS08550	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HUE59_RS08560	COG3177	Filamentation induced by cAMP protein fic
HUE59_RS08595	COG1518	maintenance of DNA repeat elements
HUE59_RS08600	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HUE59_RS08640	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUE59_RS08645	COG0444	Belongs to the ABC transporter superfamily
HUE59_RS08650	COG4608	Belongs to the ABC transporter superfamily
HUE59_RS08655	COG2723	6-phospho-beta-galactosidase activity
HUE59_RS08660	COG1309	transcriptional regulator
HUE59_RS08685	COG1518	maintenance of DNA repeat elements
HUE59_RS08690	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HUE59_RS08755	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HUE59_RS08800	COG0714	Associated with various cellular activities
HUE59_RS08815	COG1278	Cold shock
HUE59_RS08835	COG0745	RESPONSE REGULATOR receiver
HUE59_RS08840	COG2205	protein histidine kinase activity
HUE59_RS08845	COG1278	Cold shock
HUE59_RS08855	COG0589	response to stress
HUE59_RS08870	COG1196	nuclear chromosome segregation
HUE59_RS08890	COG1126	abc transporter atp-binding protein
HUE59_RS08895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUE59_RS08900	COG0765	amino acid transport
HUE59_RS08905	COG0765	amino acid transport
HUE59_RS08915	COG2326	polyphosphate kinase activity
HUE59_RS08920	COG4581	dead DEAH box helicase
HUE59_RS08930	COG2814	Major facilitator Superfamily
HUE59_RS08935	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HUE59_RS08980	COG1122	ATPase activity
HUE59_RS09015	COG1136	(ABC) transporter
HUE59_RS09015	COG0577	efflux transmembrane transporter activity
HUE59_RS09040	COG0284	orotidine-5'-phosphate decarboxylase activity
HUE59_RS09050	COG2176	DNA-directed DNA polymerase activity
HUE59_RS09055	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HUE59_RS09070	COG0765	amino acid transport
HUE59_RS09075	COG1126	abc transporter atp-binding protein
HUE59_RS09080	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUE59_RS09085	COG0626	cystathionine gamma-synthase activity
HUE59_RS09100	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HUE59_RS09115	COG0559	Belongs to the binding-protein-dependent transport system permease family
HUE59_RS09125	COG1473	amidohydrolase
HUE59_RS09140	COG1126	abc transporter atp-binding protein
HUE59_RS09145	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUE59_RS09150	COG0765	amino acid transport
HUE59_RS09165	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
HUE59_RS09190	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HUE59_RS09225	COG3480	Lon protease (S16) C-terminal proteolytic domain
HUE59_RS09270	COG1957	nucleoside hydrolase
HUE59_RS09280	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HUE59_RS09320	COG0351	phosphomethylpyrimidine kinase
HUE59_RS09320	COG0352	thiamine-phosphate diphosphorylase activity
HUE59_RS09325	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HUE59_RS09350	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HUE59_RS09380	COG1136	(ABC) transporter
HUE59_RS09380	COG0577	efflux transmembrane transporter activity
HUE59_RS09395	COG0587	DNA-directed DNA polymerase activity
HUE59_RS09405	COG4716	Myosin-crossreactive antigen
HUE59_RS09425	COG0656	L-ascorbic acid biosynthetic process
HUE59_RS09470	COG0174	glutamine synthetase
HUE59_RS09475	COG2814	Major facilitator Superfamily
HUE59_RS09490	COG0747	negative chemotaxis
HUE59_RS09505	COG1643	Atp-dependent helicase
HUE59_RS09510	COG2813	Specifically methylates the guanine in position
HUE59_RS09515	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HUE59_RS09545	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HUE59_RS09570	COG0768	penicillin binding
HUE59_RS09580	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HUE59_RS09645	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HUE59_RS09650	COG3657	addiction module killer protein
HUE59_RS09675	COG4166	transmembrane transport
HUE59_RS09680	COG0601	transmembrane transport
HUE59_RS09690	COG4172	Belongs to the ABC transporter superfamily
HUE59_RS09720	COG1940	carbohydrate kinase activity
HUE59_RS09745	COG1175	transmembrane transport
HUE59_RS09750	COG0395	ABC-type sugar transport system, permease component
HUE59_RS09765	COG0006	proline dipeptidase activity
HUE59_RS09775	COG0285	dihydrofolate synthase activity
HUE59_RS09780	COG1196	nuclear chromosome segregation
HUE59_RS09795	COG1595	DNA-templated transcription, initiation
HUE59_RS09805	COG2017	converts alpha-aldose to the beta-anomer
HUE59_RS09810	COG2017	converts alpha-aldose to the beta-anomer
HUE59_RS09820	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HUE59_RS09835	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HUE59_RS09860	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HUE59_RS09865	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HUE59_RS09875	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HUE59_RS09880	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HUE59_RS09895	COG1217	gtp-binding protein TYPA
HUE59_RS09910	COG0287	Prephenate dehydrogenase
HUE59_RS09920	COG0577	efflux transmembrane transporter activity
HUE59_RS09925	COG0577	efflux transmembrane transporter activity
HUE59_RS09925	COG1136	(ABC) transporter
HUE59_RS09935	COG4166	transmembrane transport
HUE59_RS09940	COG0601	transmembrane transport
HUE59_RS09945	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUE59_RS09955	COG0708	Exodeoxyribonuclease III
HUE59_RS09975	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HUE59_RS10025	COG0670	Belongs to the BI1 family
HUE59_RS10035	COG2357	RelA SpoT domain protein
HUE59_RS10070	COG1396	sequence-specific DNA binding
HUE59_RS10095	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HUE59_RS10110	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HUE59_RS10130	COG0142	geranyltranstransferase activity
HUE59_RS10140	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HUE59_RS10145	COG0187	DNA topoisomerase II activity
HUE59_RS10155	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HUE59_RS10160	COG1201	RNA secondary structure unwinding
HUE59_RS10170	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HUE59_RS10195	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HUE59_RS10225	COG2977	Belongs to the P-Pant transferase superfamily
HUE59_RS10235	COG0477	Major facilitator Superfamily
HUE59_RS10295	COG4974	Belongs to the 'phage' integrase family
HUE59_RS10355	COG1136	(ABC) transporter
HUE59_RS10355	COG0577	efflux transmembrane transporter activity
HUE59_RS10370	COG1131	(ABC) transporter
HUE59_RS10395	COG3850	Histidine kinase
HUE59_RS10395	COG5002	protein histidine kinase activity
HUE59_RS10425	COG0406	alpha-ribazole phosphatase activity
HUE59_RS10430	COG0598	Magnesium transport protein CorA
HUE59_RS10435	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUE59_RS10445	COG1555	photosystem II stabilization
HUE59_RS10445	COG1596	polysaccharide export
HUE59_RS10460	COG0802	atpase or kinase
HUE59_RS10470	COG0456	acetyltransferase
HUE59_RS10545	COG4585	Histidine kinase
HUE59_RS10550	COG2197	response regulator
HUE59_RS10580	COG0516	GMP reductase activity
HUE59_RS10620	COG0575	Belongs to the CDS family
HUE59_RS10650	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HUE59_RS10665	COG0488	(ABC) transporter
HUE59_RS10670	COG4221	oxidoreductase activity
HUE59_RS10695	COG2205	protein histidine kinase activity
HUE59_RS10700	COG0745	RESPONSE REGULATOR receiver
HUE59_RS10715	COG0577	efflux transmembrane transporter activity
HUE59_RS10715	COG1136	(ABC) transporter
HUE59_RS10720	COG0577	efflux transmembrane transporter activity
HUE59_RS10720	COG1136	(ABC) transporter
HUE59_RS10760	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HUE59_RS10785	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HUE59_RS10800	COG0436	Aminotransferase
HUE59_RS10815	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HUE59_RS11110	COG4974	Belongs to the 'phage' integrase family
HUE59_RS11195	COG0045	succinate-CoA ligase (ADP-forming) activity
HUE59_RS11220	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HUE59_RS11225	COG1187	pseudouridine synthase activity
HUE59_RS11270	COG1136	(ABC) transporter
HUE59_RS11290	COG1716	ATPase activity
HUE59_RS11310	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HUE59_RS11325	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HUE59_RS11340	COG0133	tryptophan synthase activity
HUE59_RS11345	COG2135	peptidase activity
HUE59_RS11355	COG0833	amino acid
HUE59_RS11415	COG3293	Transposase
HUE59_RS11430	COG3293	Transposase