locus-tag	class	description
HUE65_RS00010	COG0589	response to stress
HUE65_RS00020	COG1278	Cold shock
HUE65_RS00025	COG2205	protein histidine kinase activity
HUE65_RS00030	COG0745	RESPONSE REGULATOR receiver
HUE65_RS00050	COG1278	Cold shock
HUE65_RS00065	COG0714	Associated with various cellular activities
HUE65_RS00110	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HUE65_RS00140	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HUE65_RS00175	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HUE65_RS00180	COG1518	maintenance of DNA repeat elements
HUE65_RS00205	COG1309	transcriptional regulator
HUE65_RS00210	COG2723	6-phospho-beta-galactosidase activity
HUE65_RS00215	COG4608	Belongs to the ABC transporter superfamily
HUE65_RS00220	COG0444	Belongs to the ABC transporter superfamily
HUE65_RS00225	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUE65_RS00265	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HUE65_RS00270	COG1518	maintenance of DNA repeat elements
HUE65_RS00305	COG3177	Filamentation induced by cAMP protein fic
HUE65_RS00315	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HUE65_RS00320	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HUE65_RS00325	COG4608	Belongs to the ABC transporter superfamily
HUE65_RS00330	COG0444	Belongs to the ABC transporter superfamily
HUE65_RS00340	COG0747	negative chemotaxis
HUE65_RS00350	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
HUE65_RS00355	COG1940	carbohydrate kinase activity
HUE65_RS00365	COG2186	Transcriptional regulator
HUE65_RS00370	COG1609	Transcriptional regulator
HUE65_RS00375	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HUE65_RS00380	COG3069	C4-dicarboxylate transmembrane transporter activity
HUE65_RS00400	COG1132	(ABC) transporter
HUE65_RS00405	COG1132	(ABC) transporter
HUE65_RS00415	COG2203	Gaf domain
HUE65_RS00415	COG4251	negative regulation of phosphorylation
HUE65_RS00415	COG3706	GGDEF domain
HUE65_RS00415	COG5001	Diguanylate cyclase
HUE65_RS00510	COG0602	queuosine metabolic process
HUE65_RS00515	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HUE65_RS00515	COG1328	CTP reductase activity
HUE65_RS00520	COG1570	exodeoxyribonuclease VII activity
HUE65_RS00525	COG1722	exodeoxyribonuclease VII activity
HUE65_RS00535	COG2249	NAD(P)H dehydrogenase (quinone) activity
HUE65_RS00540	COG1022	Amp-dependent synthetase and ligase
HUE65_RS00570	COG0436	Aminotransferase
HUE65_RS00625	COG3590	peptidase
HUE65_RS00665	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HUE65_RS00680	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HUE65_RS00685	COG0009	L-threonylcarbamoyladenylate synthase
HUE65_RS00740	COG1070	Carbohydrate kinase
HUE65_RS00755	COG4214	carbohydrate transport
HUE65_RS00760	COG1129	ABC transporter
HUE65_RS00765	COG4213	ABC transporter substrate-binding protein
HUE65_RS00780	COG0110	maltose O-acetyltransferase activity
HUE65_RS00785	COG3507	Belongs to the glycosyl hydrolase 43 family
HUE65_RS00790	COG3507	Belongs to the glycosyl hydrolase 43 family
HUE65_RS00795	COG0395	ABC-type sugar transport system, permease component
HUE65_RS00810	COG1609	Transcriptional regulator
HUE65_RS00815	COG1979	alcohol dehydrogenase
HUE65_RS00825	COG2814	Major facilitator Superfamily
HUE65_RS00830	COG2814	Major facilitator Superfamily
HUE65_RS00840	COG0242	peptide deformylase activity
HUE65_RS00855	COG1940	carbohydrate kinase activity
HUE65_RS00875	COG0577	efflux transmembrane transporter activity
HUE65_RS00875	COG1136	(ABC) transporter
HUE65_RS00880	COG4591	ABC-type transport system involved in lipoprotein release permease component
HUE65_RS00880	COG1136	(ABC) transporter
HUE65_RS00925	COG1946	Acyl-CoA thioesterase
HUE65_RS00935	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HUE65_RS00940	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HUE65_RS00950	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HUE65_RS00955	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HUE65_RS00995	COG1454	alcohol dehydrogenase
HUE65_RS01000	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HUE65_RS01015	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HUE65_RS01050	COG1192	Involved in chromosome partitioning
HUE65_RS01090	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HUE65_RS01135	COG1131	(ABC) transporter
HUE65_RS01240	COG4585	Histidine kinase
HUE65_RS01245	COG2197	response regulator
HUE65_RS01255	COG1505	serine-type exopeptidase activity
HUE65_RS01280	COG4585	Histidine kinase
HUE65_RS01320	COG1131	(ABC) transporter
HUE65_RS01330	COG1132	(ABC) transporter
HUE65_RS01335	COG1136	(ABC) transporter
HUE65_RS01335	COG0577	efflux transmembrane transporter activity
HUE65_RS01345	COG4585	Histidine kinase
HUE65_RS01375	COG4974	Belongs to the 'phage' integrase family
HUE65_RS01415	COG0577	efflux transmembrane transporter activity
HUE65_RS01420	COG1136	(ABC) transporter
HUE65_RS01425	COG5002	protein histidine kinase activity
HUE65_RS01480	COG0577	efflux transmembrane transporter activity
HUE65_RS01560	COG2814	Major facilitator Superfamily
HUE65_RS01610	COG1136	(ABC) transporter
HUE65_RS01635	COG2814	Major facilitator Superfamily
HUE65_RS01670	COG1609	Transcriptional regulator
HUE65_RS01675	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HUE65_RS01695	COG1116	anion transmembrane transporter activity
HUE65_RS01725	COG2348	transferase activity, transferring amino-acyl groups
HUE65_RS01770	COG0667	Aldo Keto reductase
HUE65_RS01810	COG0440	acetolactate synthase activity
HUE65_RS01820	COG1487	ribonuclease activity
HUE65_RS01840	COG0505	Belongs to the CarA family
HUE65_RS01870	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HUE65_RS01870	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HUE65_RS01900	COG1837	Belongs to the UPF0109 family
HUE65_RS01925	COG1957	nucleoside hydrolase
HUE65_RS01950	COG1704	LemA family
HUE65_RS01975	COG0745	RESPONSE REGULATOR receiver
HUE65_RS01980	COG5002	protein histidine kinase activity
HUE65_RS01985	COG0477	Major facilitator Superfamily
HUE65_RS01990	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HUE65_RS01995	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HUE65_RS02000	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HUE65_RS02005	COG3579	cysteine-type endopeptidase activity
HUE65_RS02015	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HUE65_RS02025	COG1496	oxidoreductase activity
HUE65_RS02030	COG0826	peptidase U32
HUE65_RS02040	COG0742	ribosomal rna small subunit methyltransferase
HUE65_RS02045	COG1301	dicarboxylic acid transport
HUE65_RS02075	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HUE65_RS02075	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HUE65_RS02080	COG2270	Major facilitator Superfamily
HUE65_RS02130	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HUE65_RS02145	COG1027	Aspartate ammonia-lyase
HUE65_RS02175	COG3842	ATPase activity
HUE65_RS02210	COG0251	oxidation-reduction process
HUE65_RS02260	COG0545	Peptidyl-prolyl cis-trans isomerase
HUE65_RS02270	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HUE65_RS02305	COG0356	it plays a direct role in the translocation of protons across the membrane
HUE65_RS02380	COG0582	viral genome integration into host DNA
HUE65_RS02430	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HUE65_RS02445	COG0745	RESPONSE REGULATOR receiver
HUE65_RS02530	COG1322	Protein conserved in bacteria
HUE65_RS02535	COG1937	Protein conserved in bacteria
HUE65_RS02545	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HUE65_RS02585	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HUE65_RS02595	COG1131	(ABC) transporter
HUE65_RS02640	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HUE65_RS02660	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HUE65_RS02665	COG0305	Participates in initiation and elongation during chromosome replication
HUE65_RS02675	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HUE65_RS02700	COG1309	transcriptional regulator
HUE65_RS02705	COG1216	Glycosyl transferase, family 2
HUE65_RS02740	COG0363	glucosamine-6-phosphate deaminase activity
HUE65_RS02745	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HUE65_RS02775	COG1136	(ABC) transporter
HUE65_RS02780	COG0577	efflux transmembrane transporter activity
HUE65_RS02795	COG3470	protein probably involved in high-affinity Fe2 transport
HUE65_RS02800	COG0672	)-iron permease
HUE65_RS02820	COG3619	membrane
HUE65_RS02845	COG3152	Membrane
HUE65_RS02895	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HUE65_RS02925	COG1754	DNA topoisomerase type I activity
HUE65_RS02925	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HUE65_RS02965	COG0527	aspartate kinase activity
HUE65_RS03040	COG0586	Pfam SNARE associated Golgi protein
HUE65_RS03045	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HUE65_RS03070	COG0789	Transcriptional regulator
HUE65_RS03135	COG1268	BioY protein
HUE65_RS03140	COG1122	ATPase activity
HUE65_RS03145	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HUE65_RS03165	COG0477	Major facilitator Superfamily
HUE65_RS03215	COG0191	fructose-bisphosphate aldolase activity
HUE65_RS03240	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HUE65_RS03240	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HUE65_RS03245	COG1397	ADP-ribosylglycohydrolase
HUE65_RS03250	COG2188	Transcriptional regulator
HUE65_RS03260	COG4974	Belongs to the 'phage' integrase family
HUE65_RS03265	COG2226	methyltransferase
HUE65_RS03310	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HUE65_RS03325	COG0804	urea catabolic process
HUE65_RS03335	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HUE65_RS03355	COG0559	Belongs to the binding-protein-dependent transport system permease family
HUE65_RS03375	COG0343	queuine tRNA-ribosyltransferase activity
HUE65_RS03415	COG0071	Belongs to the small heat shock protein (HSP20) family
HUE65_RS03445	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HUE65_RS03445	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HUE65_RS03450	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HUE65_RS03495	COG0768	penicillin binding
HUE65_RS03500	COG0515	serine threonine protein kinase
HUE65_RS03540	COG0058	SHG alpha-glucan phosphorylase activity
HUE65_RS03560	COG2197	response regulator
HUE65_RS03570	COG0180	Tryptophanyl-tRNA synthetase
HUE65_RS03585	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HUE65_RS03605	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HUE65_RS03620	COG1373	ATPase (AAA superfamily
HUE65_RS03655	COG0842	Transport permease protein
HUE65_RS03655	COG1131	(ABC) transporter
HUE65_RS03655	COG1716	ATPase activity
HUE65_RS03665	COG1253	flavin adenine dinucleotide binding
HUE65_RS03670	COG0783	Belongs to the Dps family
HUE65_RS03695	COG1737	Transcriptional regulator
HUE65_RS03710	COG3639	organic phosphonate transmembrane transporter activity
HUE65_RS03760	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HUE65_RS03770	COG0542	response to heat
HUE65_RS03775	COG3266	domain, Protein
HUE65_RS03780	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HUE65_RS03785	COG0187	DNA topoisomerase II activity
HUE65_RS03800	COG0592	DNA-directed DNA polymerase activity
HUE65_RS03840	COG1192	Involved in chromosome partitioning
HUE65_RS03845	COG1475	DNA binding
HUE65_RS03870	COG0617	tRNA 3'-terminal CCA addition
HUE65_RS03890	COG3583	domain protein
HUE65_RS03915	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HUE65_RS03940	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HUE65_RS03950	COG1215	transferase activity, transferring glycosyl groups
HUE65_RS03955	COG3842	ATPase activity
HUE65_RS03965	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HUE65_RS03975	COG1263	PTS System
HUE65_RS03975	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HUE65_RS03980	COG1263	PTS System
HUE65_RS03980	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HUE65_RS03980	COG2190	(PTS) system
HUE65_RS03990	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HUE65_RS04020	COG1349	DNA-binding transcription factor activity
HUE65_RS04025	COG1486	melibiose metabolic process
HUE65_RS04030	COG1653	transport
HUE65_RS04035	COG1175	transmembrane transport
HUE65_RS04040	COG3833	ABC-type maltose transport systems, permease component
HUE65_RS04070	COG0025	NhaP-type Na H and K H
HUE65_RS04075	COG0590	tRNA wobble adenosine to inosine editing
HUE65_RS04075	COG0037	tRNA processing
HUE65_RS04095	COG1175	transmembrane transport
HUE65_RS04100	COG0395	ABC-type sugar transport system, permease component
HUE65_RS04105	COG0366	Alpha amylase catalytic
HUE65_RS04110	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HUE65_RS04115	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HUE65_RS04165	COG0778	Nitroreductase
HUE65_RS04175	COG0588	phosphoglycerate mutase activity
HUE65_RS04205	COG1113	amino acid transport
HUE65_RS04210	COG1136	(ABC) transporter
HUE65_RS04210	COG0577	efflux transmembrane transporter activity
HUE65_RS04220	COG1113	amino acid transport
HUE65_RS04225	COG1846	Transcriptional regulator
HUE65_RS04235	COG1132	(ABC) transporter
HUE65_RS04300	COG4166	transmembrane transport
HUE65_RS04330	COG1132	(ABC) transporter
HUE65_RS04335	COG1132	(ABC) transporter
HUE65_RS04345	COG3177	Filamentation induced by cAMP protein fic
HUE65_RS04355	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
HUE65_RS04365	COG0477	Major facilitator Superfamily
HUE65_RS04380	COG0084	hydrolase, TatD family'
HUE65_RS04400	COG1129	ABC transporter
HUE65_RS04420	COG1088	dTDP-glucose 4,6-dehydratase activity
HUE65_RS04425	COG1216	Glycosyl transferase, family 2
HUE65_RS04435	COG1216	Glycosyl transferase, family 2
HUE65_RS04450	COG1216	Glycosyl transferase, family 2
HUE65_RS04460	COG0463	Glycosyl transferase, family 2
HUE65_RS04485	COG1175	transmembrane transport
HUE65_RS04490	COG0395	ABC-type sugar transport system, permease component
HUE65_RS04515	COG0179	Fumarylacetoacetate (FAA) hydrolase
HUE65_RS04535	COG0584	glycerophosphoryl diester phosphodiesterase
HUE65_RS04540	COG1175	transmembrane transport
HUE65_RS04545	COG0395	ABC-type sugar transport system, permease component
HUE65_RS04595	COG3842	ATPase activity
HUE65_RS04605	COG0395	ABC-type sugar transport system, permease component
HUE65_RS04645	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HUE65_RS04660	COG4209	transmembrane transport
HUE65_RS04665	COG0395	ABC-type sugar transport system, permease component
HUE65_RS04675	COG4948	Mandelate Racemase Muconate Lactonizing
HUE65_RS04685	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HUE65_RS04690	COG4154	Belongs to the RbsD FucU family
HUE65_RS04705	COG3250	beta-galactosidase activity
HUE65_RS04725	COG0406	alpha-ribazole phosphatase activity
HUE65_RS04725	COG0494	nUDIX hydrolase
HUE65_RS04730	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HUE65_RS04755	COG0167	dihydroorotate dehydrogenase activity
HUE65_RS04760	COG0446	pyridine nucleotide-disulphide oxidoreductase
HUE65_RS04765	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HUE65_RS04775	COG0583	DNA-binding transcription factor activity
HUE65_RS04785	COG1309	transcriptional regulator
HUE65_RS04830	COG0460	homoserine dehydrogenase
HUE65_RS04835	COG0083	homoserine kinase activity
HUE65_RS04850	COG1136	(ABC) transporter
HUE65_RS04860	COG1609	Transcriptional regulator
HUE65_RS04865	COG4948	Mandelate Racemase Muconate Lactonizing
HUE65_RS04885	COG4154	Belongs to the RbsD FucU family
HUE65_RS04895	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HUE65_RS04900	COG1530	ribonuclease E activity
HUE65_RS04925	COG0436	Aminotransferase
HUE65_RS04935	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HUE65_RS04940	COG0250	Participates in transcription elongation, termination and antitermination
HUE65_RS04995	COG1414	Transcriptional regulator
HUE65_RS05005	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HUE65_RS05015	COG4977	sequence-specific DNA binding
HUE65_RS05015	COG1917	Cupin 2, conserved barrel domain protein
HUE65_RS05020	COG0673	inositol 2-dehydrogenase activity
HUE65_RS05025	COG0673	inositol 2-dehydrogenase activity
HUE65_RS05030	COG1082	Xylose isomerase domain protein TIM barrel
HUE65_RS05035	COG2814	Major facilitator Superfamily
HUE65_RS05045	COG2814	Major facilitator Superfamily
HUE65_RS05050	COG0574	Belongs to the PEP-utilizing enzyme family
HUE65_RS05050	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HUE65_RS05055	COG3959	Transketolase, thiamine diphosphate binding domain
HUE65_RS05085	COG4770	biotin carboxylase activity
HUE65_RS05090	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HUE65_RS05100	COG1621	beta-fructofuranosidase activity
HUE65_RS05105	COG0395	ABC-type sugar transport system, permease component
HUE65_RS05110	COG1175	transmembrane transport
HUE65_RS05240	COG1122	ATPase activity
HUE65_RS05245	COG1132	(ABC) transporter
HUE65_RS05260	COG2252	PERMEase
HUE65_RS05325	COG0626	cystathionine gamma-synthase activity
HUE65_RS05350	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HUE65_RS05355	COG0531	amino acid
HUE65_RS05370	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HUE65_RS05380	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HUE65_RS05385	COG1739	Uncharacterized protein family UPF0029
HUE65_RS05420	COG1012	belongs to the aldehyde dehydrogenase family
HUE65_RS05420	COG1454	alcohol dehydrogenase
HUE65_RS05430	COG3527	Alpha-acetolactate decarboxylase
HUE65_RS05480	COG0255	Belongs to the universal ribosomal protein uL29 family
HUE65_RS05585	COG2308	Evidence 4 Homologs of previously reported genes of
HUE65_RS05610	COG1175	transmembrane transport
HUE65_RS05615	COG0395	ABC-type sugar transport system, permease component
HUE65_RS05655	COG0196	riboflavin kinase activity
HUE65_RS05680	COG0328	RNA-DNA hybrid ribonuclease activity
HUE65_RS05690	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HUE65_RS05720	COG1597	lipid kinase activity
HUE65_RS05720	COG1803	Methylglyoxal synthase
HUE65_RS05755	COG2197	response regulator
HUE65_RS05795	COG2814	Major facilitator Superfamily
HUE65_RS05805	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HUE65_RS05835	COG1575	Belongs to the MenA family. Type 1 subfamily
HUE65_RS05865	COG0704	Plays a role in the regulation of phosphate uptake
HUE65_RS05870	COG5002	protein histidine kinase activity
HUE65_RS05880	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HUE65_RS05885	COG1705	Flagellar rod assembly protein muramidase FlgJ
HUE65_RS05885	COG3942	CHAP domain
HUE65_RS05895	COG0791	NLP P60 protein
HUE65_RS05900	COG0589	response to stress
HUE65_RS05920	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HUE65_RS05935	COG0577	efflux transmembrane transporter activity
HUE65_RS05965	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HUE65_RS05970	COG0560	Phosphoserine phosphatase
HUE65_RS05975	COG0586	Pfam SNARE associated Golgi protein
HUE65_RS05985	COG4122	O-methyltransferase activity
HUE65_RS06055	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HUE65_RS06095	COG0438	transferase activity, transferring glycosyl groups
HUE65_RS06095	COG4641	Protein conserved in bacteria
HUE65_RS06110	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HUE65_RS06120	COG0438	transferase activity, transferring glycosyl groups
HUE65_RS06135	COG0297	glycogen (starch) synthase activity
HUE65_RS06140	COG0438	transferase activity, transferring glycosyl groups
HUE65_RS06145	COG1088	dTDP-glucose 4,6-dehydratase activity
HUE65_RS06180	COG0758	DNA mediated transformation
HUE65_RS06195	COG0489	protein tyrosine kinase activity
HUE65_RS06205	COG1484	DNA-dependent DNA replication
HUE65_RS06280	COG0095	Lipoate-protein ligase
HUE65_RS06290	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HUE65_RS06290	COG4499	WXG100 protein secretion system (Wss), protein YukC
HUE65_RS06295	COG1902	pentaerythritol trinitrate reductase activity
HUE65_RS06300	COG0167	dihydroorotate dehydrogenase activity
HUE65_RS06305	COG1349	DNA-binding transcription factor activity
HUE65_RS06315	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HUE65_RS06320	COG0477	Major facilitator Superfamily
HUE65_RS06335	COG0477	Major facilitator Superfamily
HUE65_RS06360	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUE65_RS06370	COG2814	Major facilitator Superfamily
HUE65_RS06390	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HUE65_RS06440	COG0714	Associated with various cellular activities
HUE65_RS06460	COG0210	DNA helicase
HUE65_RS06480	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HUE65_RS06495	COG1653	transport
HUE65_RS06500	COG0395	ABC-type sugar transport system, permease component
HUE65_RS06505	COG1175	transmembrane transport
HUE65_RS06530	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HUE65_RS06535	COG2884	Cell division ATP-binding protein ftsE
HUE65_RS06540	COG2177	Part of the ABC transporter FtsEX involved in
HUE65_RS06545	COG3942	CHAP domain
HUE65_RS06545	COG1388	LysM domain
HUE65_RS06580	COG0564	pseudouridine synthase activity
HUE65_RS06605	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HUE65_RS06610	COG0747	negative chemotaxis
HUE65_RS06630	COG4608	Belongs to the ABC transporter superfamily
HUE65_RS06655	COG0626	cystathionine gamma-synthase activity
HUE65_RS06665	COG0514	ATP-dependent DNA helicase (RecQ)
HUE65_RS06680	COG0531	amino acid
HUE65_RS06685	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HUE65_RS06695	COG0358	DNA primase activity
HUE65_RS06710	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HUE65_RS06730	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HUE65_RS06745	COG0577	efflux transmembrane transporter activity
HUE65_RS06745	COG1136	(ABC) transporter
HUE65_RS06755	COG0577	efflux transmembrane transporter activity
HUE65_RS06755	COG0577	efflux transmembrane transporter activity
HUE65_RS06760	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HUE65_RS06770	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HUE65_RS06775	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HUE65_RS06820	COG0701	Predicted permease
HUE65_RS06835	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HUE65_RS06845	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HUE65_RS06850	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HUE65_RS06855	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HUE65_RS06875	COG1012	belongs to the aldehyde dehydrogenase family
HUE65_RS06905	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUE65_RS06915	COG0402	S-adenosylhomocysteine deaminase activity
HUE65_RS06920	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HUE65_RS06925	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HUE65_RS06935	COG0667	Aldo Keto reductase
HUE65_RS06975	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HUE65_RS06995	COG0436	Aminotransferase
HUE65_RS07015	COG0385	Bile acid
HUE65_RS07105	COG1063	alcohol dehydrogenase
HUE65_RS07115	COG2801	Transposase and inactivated derivatives
HUE65_RS07175	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HUE65_RS07230	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HUE65_RS07235	COG4721	ABC-type cobalt transport system, permease component
HUE65_RS07240	COG1122	ATPase activity
HUE65_RS07250	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HUE65_RS07320	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HUE65_RS07325	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HUE65_RS07350	COG0647	UMP catabolic process
HUE65_RS07375	COG0497	DNA recombination
HUE65_RS07380	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HUE65_RS07385	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HUE65_RS07390	COG2814	Major facilitator Superfamily
HUE65_RS07430	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HUE65_RS07460	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HUE65_RS07500	COG0667	Aldo Keto reductase
HUE65_RS07535	COG1760	l-serine dehydratase
HUE65_RS07545	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HUE65_RS07570	COG1316	TRANSCRIPTIONal
HUE65_RS07600	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HUE65_RS07610	COG2205	protein histidine kinase activity
HUE65_RS07615	COG0745	RESPONSE REGULATOR receiver
HUE65_RS07625	COG1329	Transcriptional regulator
HUE65_RS07640	COG1121	(ABC) transporter
HUE65_RS07645	COG0803	Belongs to the bacterial solute-binding protein 9 family
HUE65_RS07655	COG0539	negative regulation of cytoplasmic translation
HUE65_RS07665	COG1136	(ABC) transporter
HUE65_RS07665	COG0577	efflux transmembrane transporter activity
HUE65_RS07680	COG2197	response regulator
HUE65_RS07700	COG0469	pyruvate kinase activity
HUE65_RS07720	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HUE65_RS07725	COG1051	belongs to the nudix hydrolase family
HUE65_RS07750	COG0519	Catalyzes the synthesis of GMP from XMP
HUE65_RS07775	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HUE65_RS07780	COG0857	belongs to the CobB CobQ family
HUE65_RS07780	COG0280	phosphate acetyltransferase
HUE65_RS07795	COG0406	alpha-ribazole phosphatase activity
HUE65_RS07800	COG0799	negative regulation of ribosome biogenesis
HUE65_RS07820	COG2755	lipolytic protein G-D-S-L family
HUE65_RS07820	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HUE65_RS07855	COG2011	ABC-type metal ion transport system permease component
HUE65_RS07860	COG1473	amidohydrolase
HUE65_RS07875	COG1882	Formate acetyltransferase
HUE65_RS07880	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HUE65_RS07940	COG1611	Belongs to the LOG family
HUE65_RS07955	COG1053	succinate dehydrogenase
HUE65_RS07960	COG0758	DNA mediated transformation
HUE65_RS07980	COG2873	o-acetylhomoserine
HUE65_RS07985	COG1136	(ABC) transporter
HUE65_RS07990	COG1136	(ABC) transporter
HUE65_RS07990	COG0577	efflux transmembrane transporter activity
HUE65_RS07995	COG2197	response regulator
HUE65_RS08010	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HUE65_RS08015	COG0012	GTP binding
HUE65_RS08065	COG3177	Filamentation induced by cAMP protein fic
HUE65_RS08110	COG1309	transcriptional regulator
HUE65_RS08115	COG2814	Major facilitator Superfamily
HUE65_RS08125	COG2815	serine threonine protein kinase
HUE65_RS08125	COG0515	serine threonine protein kinase
HUE65_RS08195	COG2233	PERMEase
HUE65_RS08200	COG0513	Belongs to the DEAD box helicase family
HUE65_RS08215	COG0366	Alpha amylase catalytic
HUE65_RS08220	COG0306	phosphate transporter
HUE65_RS08230	COG2197	response regulator
HUE65_RS08235	COG4585	Histidine kinase
HUE65_RS08240	COG1131	(ABC) transporter
HUE65_RS08285	COG3340	Belongs to the peptidase S51 family
HUE65_RS08290	COG1335	isochorismatase
HUE65_RS08315	COG3655	Transcriptional regulator
HUE65_RS08345	COG1136	(ABC) transporter
HUE65_RS08345	COG0577	efflux transmembrane transporter activity
HUE65_RS08355	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HUE65_RS08435	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HUE65_RS08450	COG0719	Fe-S assembly protein
HUE65_RS08455	COG0396	ATPase activity
HUE65_RS08460	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HUE65_RS08470	COG2151	metal-sulfur cluster biosynthetic enzyme
HUE65_RS08490	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HUE65_RS08495	COG0537	adenosine 5'-monophosphoramidase activity
HUE65_RS08500	COG1702	phosphate starvation-inducible protein PhoH
HUE65_RS08525	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HUE65_RS08550	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HUE65_RS08560	COG2860	membrane
HUE65_RS08580	COG1929	Belongs to the glycerate kinase type-1 family
HUE65_RS08585	COG1609	Transcriptional regulator
HUE65_RS08590	COG0067	glutamate synthase
HUE65_RS08590	COG0069	glutamate synthase activity
HUE65_RS08590	COG0070	glutamate synthase
HUE65_RS08600	COG4166	transmembrane transport
HUE65_RS08615	COG0297	glycogen (starch) synthase activity
HUE65_RS08620	COG1119	ATPase activity
HUE65_RS08635	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HUE65_RS08655	COG4221	oxidoreductase activity
HUE65_RS08745	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HUE65_RS08770	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HUE65_RS08775	COG0284	orotidine-5'-phosphate decarboxylase activity
HUE65_RS08785	COG0167	dihydroorotate dehydrogenase activity
HUE65_RS08805	COG0583	DNA-binding transcription factor activity
HUE65_RS08830	COG3189	MarR family transcriptional regulator
HUE65_RS08860	COG3189	MarR family transcriptional regulator
HUE65_RS08870	COG0833	amino acid
HUE65_RS08885	COG0706	membrane insertase activity
HUE65_RS08890	COG1051	belongs to the nudix hydrolase family
HUE65_RS08960	COG3293	Transposase
HUE65_RS08975	COG3293	Transposase
HUE65_RS09035	COG0833	amino acid
HUE65_RS09045	COG2135	peptidase activity
HUE65_RS09050	COG0133	tryptophan synthase activity
HUE65_RS09065	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HUE65_RS09080	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HUE65_RS09100	COG1716	ATPase activity
HUE65_RS09120	COG1136	(ABC) transporter
HUE65_RS09165	COG1187	pseudouridine synthase activity
HUE65_RS09170	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HUE65_RS09195	COG0045	succinate-CoA ligase (ADP-forming) activity
HUE65_RS09280	COG4974	Belongs to the 'phage' integrase family
HUE65_RS09575	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HUE65_RS09590	COG0436	Aminotransferase
HUE65_RS09605	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HUE65_RS09630	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HUE65_RS09670	COG1136	(ABC) transporter
HUE65_RS09670	COG0577	efflux transmembrane transporter activity
HUE65_RS09675	COG1136	(ABC) transporter
HUE65_RS09675	COG0577	efflux transmembrane transporter activity
HUE65_RS09690	COG0745	RESPONSE REGULATOR receiver
HUE65_RS09695	COG2205	protein histidine kinase activity
HUE65_RS09720	COG4221	oxidoreductase activity
HUE65_RS09725	COG0488	(ABC) transporter
HUE65_RS09740	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HUE65_RS09770	COG0575	Belongs to the CDS family
HUE65_RS09810	COG0516	GMP reductase activity
HUE65_RS09840	COG2197	response regulator
HUE65_RS09845	COG4585	Histidine kinase
HUE65_RS09920	COG0456	acetyltransferase
HUE65_RS09930	COG0802	atpase or kinase
HUE65_RS09945	COG1596	polysaccharide export
HUE65_RS09945	COG1555	photosystem II stabilization
HUE65_RS09955	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUE65_RS09960	COG0598	Magnesium transport protein CorA
HUE65_RS09965	COG0406	alpha-ribazole phosphatase activity
HUE65_RS09995	COG5002	protein histidine kinase activity
HUE65_RS09995	COG3850	Histidine kinase
HUE65_RS10020	COG1131	(ABC) transporter
HUE65_RS10035	COG0577	efflux transmembrane transporter activity
HUE65_RS10035	COG1136	(ABC) transporter
HUE65_RS10090	COG4974	Belongs to the 'phage' integrase family
HUE65_RS10150	COG0477	Major facilitator Superfamily
HUE65_RS10160	COG2977	Belongs to the P-Pant transferase superfamily
HUE65_RS10190	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HUE65_RS10215	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HUE65_RS10225	COG1201	RNA secondary structure unwinding
HUE65_RS10230	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HUE65_RS10240	COG0187	DNA topoisomerase II activity
HUE65_RS10245	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HUE65_RS10255	COG0142	geranyltranstransferase activity
HUE65_RS10275	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HUE65_RS10290	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HUE65_RS10315	COG1396	sequence-specific DNA binding
HUE65_RS10350	COG2357	RelA SpoT domain protein
HUE65_RS10360	COG0670	Belongs to the BI1 family
HUE65_RS10410	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HUE65_RS10430	COG0708	Exodeoxyribonuclease III
HUE65_RS10440	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUE65_RS10445	COG0601	transmembrane transport
HUE65_RS10450	COG4166	transmembrane transport
HUE65_RS10460	COG1136	(ABC) transporter
HUE65_RS10460	COG0577	efflux transmembrane transporter activity
HUE65_RS10465	COG0577	efflux transmembrane transporter activity
HUE65_RS10475	COG0287	Prephenate dehydrogenase
HUE65_RS10490	COG1217	gtp-binding protein TYPA
HUE65_RS10505	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HUE65_RS10510	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HUE65_RS10520	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HUE65_RS10525	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HUE65_RS10550	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HUE65_RS10565	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HUE65_RS10575	COG2017	converts alpha-aldose to the beta-anomer
HUE65_RS10580	COG2017	converts alpha-aldose to the beta-anomer
HUE65_RS10590	COG1595	DNA-templated transcription, initiation
HUE65_RS10605	COG1196	nuclear chromosome segregation
HUE65_RS10610	COG0285	dihydrofolate synthase activity
HUE65_RS10620	COG0006	proline dipeptidase activity
HUE65_RS10635	COG0395	ABC-type sugar transport system, permease component
HUE65_RS10640	COG1175	transmembrane transport
HUE65_RS10665	COG1940	carbohydrate kinase activity
HUE65_RS10695	COG4172	Belongs to the ABC transporter superfamily
HUE65_RS10705	COG0601	transmembrane transport
HUE65_RS10710	COG4166	transmembrane transport
HUE65_RS10735	COG3657	addiction module killer protein
HUE65_RS10740	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HUE65_RS10805	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HUE65_RS10815	COG0768	penicillin binding
HUE65_RS10840	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HUE65_RS10870	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HUE65_RS10875	COG2813	Specifically methylates the guanine in position
HUE65_RS10880	COG1643	Atp-dependent helicase
HUE65_RS10895	COG0747	negative chemotaxis
HUE65_RS10910	COG2814	Major facilitator Superfamily
HUE65_RS10915	COG0174	glutamine synthetase
HUE65_RS10960	COG0656	L-ascorbic acid biosynthetic process
HUE65_RS10980	COG4716	Myosin-crossreactive antigen
HUE65_RS10990	COG0587	DNA-directed DNA polymerase activity
HUE65_RS11005	COG0577	efflux transmembrane transporter activity
HUE65_RS11005	COG1136	(ABC) transporter
HUE65_RS11035	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HUE65_RS11060	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HUE65_RS11065	COG0352	thiamine-phosphate diphosphorylase activity
HUE65_RS11065	COG0351	phosphomethylpyrimidine kinase
HUE65_RS11090	COG1609	Transcriptional regulator
HUE65_RS11105	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HUE65_RS11115	COG1957	nucleoside hydrolase
HUE65_RS11160	COG3480	Lon protease (S16) C-terminal proteolytic domain
HUE65_RS11195	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HUE65_RS11220	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
HUE65_RS11235	COG0765	amino acid transport
HUE65_RS11240	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUE65_RS11245	COG1126	abc transporter atp-binding protein
HUE65_RS11260	COG1473	amidohydrolase
HUE65_RS11270	COG0559	Belongs to the binding-protein-dependent transport system permease family
HUE65_RS11285	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HUE65_RS11300	COG0626	cystathionine gamma-synthase activity
HUE65_RS11305	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUE65_RS11310	COG1126	abc transporter atp-binding protein
HUE65_RS11315	COG0765	amino acid transport
HUE65_RS11330	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HUE65_RS11335	COG2176	DNA-directed DNA polymerase activity
HUE65_RS11345	COG0284	orotidine-5'-phosphate decarboxylase activity
HUE65_RS11370	COG0577	efflux transmembrane transporter activity
HUE65_RS11370	COG1136	(ABC) transporter
HUE65_RS11405	COG1122	ATPase activity
HUE65_RS11450	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HUE65_RS11455	COG2814	Major facilitator Superfamily
HUE65_RS11465	COG4581	dead DEAH box helicase
HUE65_RS11470	COG2326	polyphosphate kinase activity
HUE65_RS11480	COG0765	amino acid transport
HUE65_RS11485	COG0765	amino acid transport
HUE65_RS11490	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUE65_RS11495	COG1126	abc transporter atp-binding protein