locus-tag	class	description
HUE69_RS00005	COG5002	protein histidine kinase activity
HUE69_RS00010	COG1136	(ABC) transporter
HUE69_RS00015	COG0577	efflux transmembrane transporter activity
HUE69_RS00055	COG4974	Belongs to the 'phage' integrase family
HUE69_RS00085	COG4585	Histidine kinase
HUE69_RS00095	COG0577	efflux transmembrane transporter activity
HUE69_RS00095	COG1136	(ABC) transporter
HUE69_RS00100	COG1132	(ABC) transporter
HUE69_RS00110	COG1131	(ABC) transporter
HUE69_RS00150	COG4585	Histidine kinase
HUE69_RS00175	COG1505	serine-type exopeptidase activity
HUE69_RS00190	COG2197	response regulator
HUE69_RS00195	COG4585	Histidine kinase
HUE69_RS00300	COG1131	(ABC) transporter
HUE69_RS00345	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HUE69_RS00385	COG1192	Involved in chromosome partitioning
HUE69_RS00420	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HUE69_RS00435	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HUE69_RS00440	COG1454	alcohol dehydrogenase
HUE69_RS00480	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HUE69_RS00485	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HUE69_RS00495	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HUE69_RS00500	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HUE69_RS00510	COG1946	Acyl-CoA thioesterase
HUE69_RS00555	COG4591	ABC-type transport system involved in lipoprotein release permease component
HUE69_RS00555	COG1136	(ABC) transporter
HUE69_RS00560	COG0577	efflux transmembrane transporter activity
HUE69_RS00560	COG1136	(ABC) transporter
HUE69_RS00580	COG1940	carbohydrate kinase activity
HUE69_RS00595	COG0242	peptide deformylase activity
HUE69_RS00605	COG2814	Major facilitator Superfamily
HUE69_RS00610	COG2814	Major facilitator Superfamily
HUE69_RS00620	COG1979	alcohol dehydrogenase
HUE69_RS00625	COG1609	Transcriptional regulator
HUE69_RS00640	COG0395	ABC-type sugar transport system, permease component
HUE69_RS00645	COG3507	Belongs to the glycosyl hydrolase 43 family
HUE69_RS00650	COG3507	Belongs to the glycosyl hydrolase 43 family
HUE69_RS00655	COG0110	maltose O-acetyltransferase activity
HUE69_RS00670	COG4213	ABC transporter substrate-binding protein
HUE69_RS00675	COG1129	ABC transporter
HUE69_RS00680	COG4214	carbohydrate transport
HUE69_RS00695	COG1070	Carbohydrate kinase
HUE69_RS00750	COG0009	L-threonylcarbamoyladenylate synthase
HUE69_RS00755	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HUE69_RS00770	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HUE69_RS00810	COG3590	peptidase
HUE69_RS00865	COG0436	Aminotransferase
HUE69_RS00895	COG1022	Amp-dependent synthetase and ligase
HUE69_RS00900	COG2249	NAD(P)H dehydrogenase (quinone) activity
HUE69_RS00910	COG1722	exodeoxyribonuclease VII activity
HUE69_RS00915	COG1570	exodeoxyribonuclease VII activity
HUE69_RS00920	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HUE69_RS00920	COG1328	CTP reductase activity
HUE69_RS00925	COG0602	queuosine metabolic process
HUE69_RS01015	COG3706	GGDEF domain
HUE69_RS01015	COG4251	negative regulation of phosphorylation
HUE69_RS01015	COG5001	Diguanylate cyclase
HUE69_RS01015	COG2203	Gaf domain
HUE69_RS01025	COG1132	(ABC) transporter
HUE69_RS01030	COG1132	(ABC) transporter
HUE69_RS01050	COG3069	C4-dicarboxylate transmembrane transporter activity
HUE69_RS01055	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HUE69_RS01060	COG1609	Transcriptional regulator
HUE69_RS01065	COG2186	Transcriptional regulator
HUE69_RS01075	COG1940	carbohydrate kinase activity
HUE69_RS01080	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
HUE69_RS01090	COG0747	negative chemotaxis
HUE69_RS01100	COG0444	Belongs to the ABC transporter superfamily
HUE69_RS01105	COG4608	Belongs to the ABC transporter superfamily
HUE69_RS01110	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HUE69_RS01115	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HUE69_RS01125	COG3177	Filamentation induced by cAMP protein fic
HUE69_RS01160	COG1518	maintenance of DNA repeat elements
HUE69_RS01165	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HUE69_RS01205	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUE69_RS01210	COG0444	Belongs to the ABC transporter superfamily
HUE69_RS01215	COG4608	Belongs to the ABC transporter superfamily
HUE69_RS01220	COG2723	6-phospho-beta-galactosidase activity
HUE69_RS01225	COG1309	transcriptional regulator
HUE69_RS01250	COG1518	maintenance of DNA repeat elements
HUE69_RS01255	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HUE69_RS01320	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HUE69_RS01365	COG0714	Associated with various cellular activities
HUE69_RS01380	COG1278	Cold shock
HUE69_RS01400	COG0745	RESPONSE REGULATOR receiver
HUE69_RS01405	COG2205	protein histidine kinase activity
HUE69_RS01410	COG1278	Cold shock
HUE69_RS01420	COG0589	response to stress
HUE69_RS01435	COG1196	nuclear chromosome segregation
HUE69_RS01455	COG1126	abc transporter atp-binding protein
HUE69_RS01460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUE69_RS01465	COG0765	amino acid transport
HUE69_RS01470	COG0765	amino acid transport
HUE69_RS01480	COG2326	polyphosphate kinase activity
HUE69_RS01485	COG4581	dead DEAH box helicase
HUE69_RS01495	COG2814	Major facilitator Superfamily
HUE69_RS01500	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HUE69_RS01545	COG1122	ATPase activity
HUE69_RS01580	COG1136	(ABC) transporter
HUE69_RS01580	COG0577	efflux transmembrane transporter activity
HUE69_RS01605	COG0284	orotidine-5'-phosphate decarboxylase activity
HUE69_RS01615	COG2176	DNA-directed DNA polymerase activity
HUE69_RS01620	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HUE69_RS01635	COG0765	amino acid transport
HUE69_RS01640	COG1126	abc transporter atp-binding protein
HUE69_RS01645	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUE69_RS01650	COG0626	cystathionine gamma-synthase activity
HUE69_RS01665	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HUE69_RS01680	COG0559	Belongs to the binding-protein-dependent transport system permease family
HUE69_RS01690	COG1473	amidohydrolase
HUE69_RS01705	COG1126	abc transporter atp-binding protein
HUE69_RS01710	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUE69_RS01715	COG0765	amino acid transport
HUE69_RS01730	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
HUE69_RS01755	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HUE69_RS01790	COG3480	Lon protease (S16) C-terminal proteolytic domain
HUE69_RS01835	COG1957	nucleoside hydrolase
HUE69_RS01845	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HUE69_RS01885	COG0351	phosphomethylpyrimidine kinase
HUE69_RS01885	COG0352	thiamine-phosphate diphosphorylase activity
HUE69_RS01890	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HUE69_RS01915	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HUE69_RS01945	COG1136	(ABC) transporter
HUE69_RS01945	COG0577	efflux transmembrane transporter activity
HUE69_RS01960	COG0587	DNA-directed DNA polymerase activity
HUE69_RS01970	COG4716	Myosin-crossreactive antigen
HUE69_RS01990	COG0656	L-ascorbic acid biosynthetic process
HUE69_RS02035	COG0174	glutamine synthetase
HUE69_RS02040	COG2814	Major facilitator Superfamily
HUE69_RS02055	COG0747	negative chemotaxis
HUE69_RS02070	COG1643	Atp-dependent helicase
HUE69_RS02075	COG2813	Specifically methylates the guanine in position
HUE69_RS02080	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HUE69_RS02110	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HUE69_RS02135	COG0768	penicillin binding
HUE69_RS02145	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HUE69_RS02210	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HUE69_RS02215	COG3657	addiction module killer protein
HUE69_RS02240	COG4166	transmembrane transport
HUE69_RS02245	COG0601	transmembrane transport
HUE69_RS02255	COG4172	Belongs to the ABC transporter superfamily
HUE69_RS02285	COG1940	carbohydrate kinase activity
HUE69_RS02310	COG1175	transmembrane transport
HUE69_RS02315	COG0395	ABC-type sugar transport system, permease component
HUE69_RS02330	COG0006	proline dipeptidase activity
HUE69_RS02340	COG0285	dihydrofolate synthase activity
HUE69_RS02345	COG1196	nuclear chromosome segregation
HUE69_RS02360	COG1595	DNA-templated transcription, initiation
HUE69_RS02370	COG2017	converts alpha-aldose to the beta-anomer
HUE69_RS02375	COG2017	converts alpha-aldose to the beta-anomer
HUE69_RS02385	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HUE69_RS02400	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HUE69_RS02425	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HUE69_RS02430	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HUE69_RS02440	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HUE69_RS02445	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HUE69_RS02460	COG1217	gtp-binding protein TYPA
HUE69_RS02475	COG0287	Prephenate dehydrogenase
HUE69_RS02485	COG0577	efflux transmembrane transporter activity
HUE69_RS02490	COG0577	efflux transmembrane transporter activity
HUE69_RS02490	COG1136	(ABC) transporter
HUE69_RS02500	COG4166	transmembrane transport
HUE69_RS02505	COG0601	transmembrane transport
HUE69_RS02510	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HUE69_RS02520	COG0708	Exodeoxyribonuclease III
HUE69_RS02540	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HUE69_RS02590	COG0670	Belongs to the BI1 family
HUE69_RS02600	COG2357	RelA SpoT domain protein
HUE69_RS02635	COG1396	sequence-specific DNA binding
HUE69_RS02660	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HUE69_RS02675	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HUE69_RS02695	COG0142	geranyltranstransferase activity
HUE69_RS02705	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HUE69_RS02710	COG0187	DNA topoisomerase II activity
HUE69_RS02720	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HUE69_RS02725	COG1201	RNA secondary structure unwinding
HUE69_RS02735	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HUE69_RS02760	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HUE69_RS02790	COG2977	Belongs to the P-Pant transferase superfamily
HUE69_RS02800	COG0477	Major facilitator Superfamily
HUE69_RS02860	COG4974	Belongs to the 'phage' integrase family
HUE69_RS02920	COG1136	(ABC) transporter
HUE69_RS02920	COG0577	efflux transmembrane transporter activity
HUE69_RS02935	COG1131	(ABC) transporter
HUE69_RS02960	COG3850	Histidine kinase
HUE69_RS02960	COG5002	protein histidine kinase activity
HUE69_RS02990	COG0406	alpha-ribazole phosphatase activity
HUE69_RS02995	COG0598	Magnesium transport protein CorA
HUE69_RS03000	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUE69_RS03010	COG1555	photosystem II stabilization
HUE69_RS03010	COG1596	polysaccharide export
HUE69_RS03025	COG0802	atpase or kinase
HUE69_RS03035	COG0456	acetyltransferase
HUE69_RS03110	COG4585	Histidine kinase
HUE69_RS03115	COG2197	response regulator
HUE69_RS03145	COG0516	GMP reductase activity
HUE69_RS03185	COG0575	Belongs to the CDS family
HUE69_RS03215	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HUE69_RS03230	COG0488	(ABC) transporter
HUE69_RS03235	COG4221	oxidoreductase activity
HUE69_RS03260	COG2205	protein histidine kinase activity
HUE69_RS03265	COG0745	RESPONSE REGULATOR receiver
HUE69_RS03280	COG0577	efflux transmembrane transporter activity
HUE69_RS03280	COG1136	(ABC) transporter
HUE69_RS03285	COG1136	(ABC) transporter
HUE69_RS03285	COG0577	efflux transmembrane transporter activity
HUE69_RS03325	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HUE69_RS03360	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HUE69_RS03375	COG0436	Aminotransferase
HUE69_RS03390	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HUE69_RS03685	COG4974	Belongs to the 'phage' integrase family
HUE69_RS03770	COG0045	succinate-CoA ligase (ADP-forming) activity
HUE69_RS03795	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HUE69_RS03800	COG1187	pseudouridine synthase activity
HUE69_RS03845	COG1136	(ABC) transporter
HUE69_RS03865	COG1716	ATPase activity
HUE69_RS03885	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HUE69_RS03900	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HUE69_RS03915	COG0133	tryptophan synthase activity
HUE69_RS03920	COG2135	peptidase activity
HUE69_RS03930	COG0833	amino acid
HUE69_RS03990	COG3293	Transposase
HUE69_RS04005	COG3293	Transposase
HUE69_RS04075	COG1051	belongs to the nudix hydrolase family
HUE69_RS04080	COG0706	membrane insertase activity
HUE69_RS04095	COG0833	amino acid
HUE69_RS04105	COG3189	MarR family transcriptional regulator
HUE69_RS04135	COG3189	MarR family transcriptional regulator
HUE69_RS04160	COG0583	DNA-binding transcription factor activity
HUE69_RS04180	COG0167	dihydroorotate dehydrogenase activity
HUE69_RS04190	COG0284	orotidine-5'-phosphate decarboxylase activity
HUE69_RS04195	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HUE69_RS04220	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HUE69_RS04310	COG4221	oxidoreductase activity
HUE69_RS04330	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HUE69_RS04340	COG0561	phosphatase activity
HUE69_RS04340	COG0561	phosphatase activity
HUE69_RS04345	COG1119	ATPase activity
HUE69_RS04350	COG0297	glycogen (starch) synthase activity
HUE69_RS04365	COG4166	transmembrane transport
HUE69_RS04375	COG0067	glutamate synthase
HUE69_RS04375	COG0069	glutamate synthase activity
HUE69_RS04375	COG0070	glutamate synthase
HUE69_RS04380	COG1609	Transcriptional regulator
HUE69_RS04385	COG1929	Belongs to the glycerate kinase type-1 family
HUE69_RS04405	COG2860	membrane
HUE69_RS04415	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HUE69_RS04440	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HUE69_RS04465	COG1702	phosphate starvation-inducible protein PhoH
HUE69_RS04470	COG0537	adenosine 5'-monophosphoramidase activity
HUE69_RS04475	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HUE69_RS04495	COG2151	metal-sulfur cluster biosynthetic enzyme
HUE69_RS04505	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HUE69_RS04510	COG0396	ATPase activity
HUE69_RS04515	COG0719	Fe-S assembly protein
HUE69_RS04530	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HUE69_RS04610	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HUE69_RS04620	COG0577	efflux transmembrane transporter activity
HUE69_RS04620	COG1136	(ABC) transporter
HUE69_RS04650	COG3655	Transcriptional regulator
HUE69_RS04675	COG1335	isochorismatase
HUE69_RS04680	COG3340	Belongs to the peptidase S51 family
HUE69_RS04725	COG1131	(ABC) transporter
HUE69_RS04730	COG4585	Histidine kinase
HUE69_RS04735	COG2197	response regulator
HUE69_RS04745	COG0306	phosphate transporter
HUE69_RS04750	COG0366	Alpha amylase catalytic
HUE69_RS04765	COG0513	Belongs to the DEAD box helicase family
HUE69_RS04770	COG2233	PERMEase
HUE69_RS04840	COG0515	serine threonine protein kinase
HUE69_RS04840	COG2815	serine threonine protein kinase
HUE69_RS04850	COG2814	Major facilitator Superfamily
HUE69_RS04855	COG1309	transcriptional regulator
HUE69_RS04900	COG3177	Filamentation induced by cAMP protein fic
HUE69_RS04950	COG0012	GTP binding
HUE69_RS04955	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HUE69_RS04970	COG2197	response regulator
HUE69_RS04975	COG0577	efflux transmembrane transporter activity
HUE69_RS04975	COG1136	(ABC) transporter
HUE69_RS04980	COG1136	(ABC) transporter
HUE69_RS04985	COG2873	o-acetylhomoserine
HUE69_RS05005	COG0758	DNA mediated transformation
HUE69_RS05010	COG1053	succinate dehydrogenase
HUE69_RS05025	COG1611	Belongs to the LOG family
HUE69_RS05085	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HUE69_RS05090	COG1882	Formate acetyltransferase
HUE69_RS05105	COG1473	amidohydrolase
HUE69_RS05110	COG2011	ABC-type metal ion transport system permease component
HUE69_RS05140	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HUE69_RS05140	COG2755	lipolytic protein G-D-S-L family
HUE69_RS05160	COG0799	negative regulation of ribosome biogenesis
HUE69_RS05165	COG0406	alpha-ribazole phosphatase activity
HUE69_RS05180	COG0280	phosphate acetyltransferase
HUE69_RS05180	COG0857	belongs to the CobB CobQ family
HUE69_RS05185	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HUE69_RS05210	COG0519	Catalyzes the synthesis of GMP from XMP
HUE69_RS05235	COG1051	belongs to the nudix hydrolase family
HUE69_RS05240	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HUE69_RS05260	COG0469	pyruvate kinase activity
HUE69_RS05280	COG2197	response regulator
HUE69_RS05295	COG0577	efflux transmembrane transporter activity
HUE69_RS05295	COG1136	(ABC) transporter
HUE69_RS05305	COG0539	negative regulation of cytoplasmic translation
HUE69_RS05315	COG0803	Belongs to the bacterial solute-binding protein 9 family
HUE69_RS05320	COG1121	(ABC) transporter
HUE69_RS05335	COG1329	Transcriptional regulator
HUE69_RS05345	COG0745	RESPONSE REGULATOR receiver
HUE69_RS05350	COG2205	protein histidine kinase activity
HUE69_RS05360	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HUE69_RS05390	COG1316	TRANSCRIPTIONal
HUE69_RS05415	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HUE69_RS05425	COG1760	l-serine dehydratase
HUE69_RS05460	COG0667	Aldo Keto reductase
HUE69_RS05500	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HUE69_RS05530	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HUE69_RS05570	COG2814	Major facilitator Superfamily
HUE69_RS05575	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HUE69_RS05580	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HUE69_RS05585	COG0497	DNA recombination
HUE69_RS05610	COG0647	UMP catabolic process
HUE69_RS05635	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HUE69_RS05640	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HUE69_RS05710	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HUE69_RS05720	COG1122	ATPase activity
HUE69_RS05725	COG4721	ABC-type cobalt transport system, permease component
HUE69_RS05730	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HUE69_RS05785	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HUE69_RS05845	COG2801	Transposase and inactivated derivatives
HUE69_RS05855	COG1063	alcohol dehydrogenase
HUE69_RS05880	COG0583	DNA-binding transcription factor activity
HUE69_RS05945	COG0385	Bile acid
HUE69_RS05965	COG0436	Aminotransferase
HUE69_RS05985	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HUE69_RS06025	COG0667	Aldo Keto reductase
HUE69_RS06035	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HUE69_RS06040	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HUE69_RS06045	COG0402	S-adenosylhomocysteine deaminase activity
HUE69_RS06055	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HUE69_RS06085	COG1012	belongs to the aldehyde dehydrogenase family
HUE69_RS06105	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HUE69_RS06110	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HUE69_RS06115	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HUE69_RS06125	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HUE69_RS06140	COG0701	Predicted permease
HUE69_RS06185	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HUE69_RS06190	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HUE69_RS06200	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HUE69_RS06205	COG0577	efflux transmembrane transporter activity
HUE69_RS06205	COG0577	efflux transmembrane transporter activity
HUE69_RS06215	COG1136	(ABC) transporter
HUE69_RS06215	COG0577	efflux transmembrane transporter activity
HUE69_RS06230	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HUE69_RS06250	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HUE69_RS06265	COG0358	DNA primase activity
HUE69_RS06275	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HUE69_RS06280	COG0531	amino acid
HUE69_RS06295	COG0514	ATP-dependent DNA helicase (RecQ)
HUE69_RS06305	COG0626	cystathionine gamma-synthase activity
HUE69_RS06330	COG4608	Belongs to the ABC transporter superfamily
HUE69_RS06350	COG0747	negative chemotaxis
HUE69_RS06355	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HUE69_RS06380	COG0564	pseudouridine synthase activity
HUE69_RS06415	COG1388	LysM domain
HUE69_RS06415	COG3942	CHAP domain
HUE69_RS06420	COG2177	Part of the ABC transporter FtsEX involved in
HUE69_RS06425	COG2884	Cell division ATP-binding protein ftsE
HUE69_RS06430	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HUE69_RS06455	COG1175	transmembrane transport
HUE69_RS06460	COG0395	ABC-type sugar transport system, permease component
HUE69_RS06465	COG1653	transport
HUE69_RS06480	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HUE69_RS06500	COG0210	DNA helicase
HUE69_RS06520	COG0714	Associated with various cellular activities
HUE69_RS06570	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HUE69_RS06590	COG2814	Major facilitator Superfamily
HUE69_RS06600	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HUE69_RS06620	COG0477	Major facilitator Superfamily
HUE69_RS06635	COG0477	Major facilitator Superfamily
HUE69_RS06640	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HUE69_RS06650	COG1349	DNA-binding transcription factor activity
HUE69_RS06655	COG0167	dihydroorotate dehydrogenase activity
HUE69_RS06660	COG1902	pentaerythritol trinitrate reductase activity
HUE69_RS06665	COG4499	WXG100 protein secretion system (Wss), protein YukC
HUE69_RS06665	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HUE69_RS06675	COG0095	Lipoate-protein ligase
HUE69_RS06750	COG1484	DNA-dependent DNA replication
HUE69_RS06760	COG0489	protein tyrosine kinase activity
HUE69_RS06775	COG0758	DNA mediated transformation
HUE69_RS06810	COG1088	dTDP-glucose 4,6-dehydratase activity
HUE69_RS06815	COG0438	transferase activity, transferring glycosyl groups
HUE69_RS06820	COG0297	glycogen (starch) synthase activity
HUE69_RS06835	COG0438	transferase activity, transferring glycosyl groups
HUE69_RS06845	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HUE69_RS06860	COG0438	transferase activity, transferring glycosyl groups
HUE69_RS06860	COG4641	Protein conserved in bacteria
HUE69_RS06905	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HUE69_RS06975	COG4122	O-methyltransferase activity
HUE69_RS06985	COG0586	Pfam SNARE associated Golgi protein
HUE69_RS06990	COG0560	Phosphoserine phosphatase
HUE69_RS06995	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HUE69_RS07025	COG0577	efflux transmembrane transporter activity
HUE69_RS07040	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HUE69_RS07060	COG0589	response to stress
HUE69_RS07065	COG0791	NLP P60 protein
HUE69_RS07075	COG3942	CHAP domain
HUE69_RS07075	COG1705	Flagellar rod assembly protein muramidase FlgJ
HUE69_RS07080	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HUE69_RS07090	COG5002	protein histidine kinase activity
HUE69_RS07095	COG0704	Plays a role in the regulation of phosphate uptake
HUE69_RS07125	COG1575	Belongs to the MenA family. Type 1 subfamily
HUE69_RS07155	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HUE69_RS07165	COG2814	Major facilitator Superfamily
HUE69_RS07205	COG2197	response regulator
HUE69_RS07240	COG1597	lipid kinase activity
HUE69_RS07240	COG1803	Methylglyoxal synthase
HUE69_RS07270	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HUE69_RS07280	COG0328	RNA-DNA hybrid ribonuclease activity
HUE69_RS07305	COG0196	riboflavin kinase activity
HUE69_RS07345	COG0395	ABC-type sugar transport system, permease component
HUE69_RS07350	COG1175	transmembrane transport
HUE69_RS07375	COG2308	Evidence 4 Homologs of previously reported genes of
HUE69_RS07480	COG0255	Belongs to the universal ribosomal protein uL29 family
HUE69_RS07530	COG3527	Alpha-acetolactate decarboxylase
HUE69_RS07540	COG1454	alcohol dehydrogenase
HUE69_RS07540	COG1012	belongs to the aldehyde dehydrogenase family
HUE69_RS07575	COG1739	Uncharacterized protein family UPF0029
HUE69_RS07580	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HUE69_RS07590	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HUE69_RS07605	COG0531	amino acid
HUE69_RS07610	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HUE69_RS07635	COG0626	cystathionine gamma-synthase activity
HUE69_RS07700	COG2252	PERMEase
HUE69_RS07715	COG1132	(ABC) transporter
HUE69_RS07720	COG1122	ATPase activity
HUE69_RS07780	COG2176	DNA-directed DNA polymerase activity
HUE69_RS07845	COG1175	transmembrane transport
HUE69_RS07850	COG0395	ABC-type sugar transport system, permease component
HUE69_RS07855	COG1621	beta-fructofuranosidase activity
HUE69_RS07865	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HUE69_RS07870	COG4770	biotin carboxylase activity
HUE69_RS07900	COG3959	Transketolase, thiamine diphosphate binding domain
HUE69_RS07905	COG0574	Belongs to the PEP-utilizing enzyme family
HUE69_RS07905	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HUE69_RS07910	COG2814	Major facilitator Superfamily
HUE69_RS07920	COG2814	Major facilitator Superfamily
HUE69_RS07925	COG1082	Xylose isomerase domain protein TIM barrel
HUE69_RS07930	COG0673	inositol 2-dehydrogenase activity
HUE69_RS07935	COG0673	inositol 2-dehydrogenase activity
HUE69_RS07940	COG4977	sequence-specific DNA binding
HUE69_RS07940	COG1917	Cupin 2, conserved barrel domain protein
HUE69_RS07950	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HUE69_RS07960	COG1414	Transcriptional regulator
HUE69_RS08015	COG0250	Participates in transcription elongation, termination and antitermination
HUE69_RS08020	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HUE69_RS08030	COG0436	Aminotransferase
HUE69_RS08055	COG1530	ribonuclease E activity
HUE69_RS08060	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HUE69_RS08070	COG4154	Belongs to the RbsD FucU family
HUE69_RS08090	COG4948	Mandelate Racemase Muconate Lactonizing
HUE69_RS08095	COG1609	Transcriptional regulator
HUE69_RS08105	COG1136	(ABC) transporter
HUE69_RS08120	COG0083	homoserine kinase activity
HUE69_RS08125	COG0460	homoserine dehydrogenase
HUE69_RS08170	COG1309	transcriptional regulator
HUE69_RS08180	COG0583	DNA-binding transcription factor activity
HUE69_RS08190	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HUE69_RS08195	COG0446	pyridine nucleotide-disulphide oxidoreductase
HUE69_RS08200	COG0167	dihydroorotate dehydrogenase activity
HUE69_RS08225	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HUE69_RS08230	COG0406	alpha-ribazole phosphatase activity
HUE69_RS08230	COG0494	nUDIX hydrolase
HUE69_RS08250	COG3250	beta-galactosidase activity
HUE69_RS08265	COG4154	Belongs to the RbsD FucU family
HUE69_RS08270	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HUE69_RS08280	COG4948	Mandelate Racemase Muconate Lactonizing
HUE69_RS08290	COG0395	ABC-type sugar transport system, permease component
HUE69_RS08295	COG4209	transmembrane transport
HUE69_RS08310	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HUE69_RS08350	COG0395	ABC-type sugar transport system, permease component
HUE69_RS08360	COG3842	ATPase activity
HUE69_RS08410	COG0395	ABC-type sugar transport system, permease component
HUE69_RS08415	COG1175	transmembrane transport
HUE69_RS08420	COG0584	glycerophosphoryl diester phosphodiesterase
HUE69_RS08440	COG0179	Fumarylacetoacetate (FAA) hydrolase
HUE69_RS08465	COG0395	ABC-type sugar transport system, permease component
HUE69_RS08470	COG1175	transmembrane transport
HUE69_RS08495	COG0463	Glycosyl transferase, family 2
HUE69_RS08505	COG1216	Glycosyl transferase, family 2
HUE69_RS08520	COG1216	Glycosyl transferase, family 2
HUE69_RS08530	COG1216	Glycosyl transferase, family 2
HUE69_RS08535	COG1088	dTDP-glucose 4,6-dehydratase activity
HUE69_RS08555	COG1129	ABC transporter
HUE69_RS08575	COG0084	hydrolase, TatD family'
HUE69_RS08590	COG0477	Major facilitator Superfamily
HUE69_RS08600	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
HUE69_RS08610	COG3177	Filamentation induced by cAMP protein fic
HUE69_RS08620	COG1132	(ABC) transporter
HUE69_RS08625	COG1132	(ABC) transporter
HUE69_RS08655	COG4166	transmembrane transport
HUE69_RS08720	COG1132	(ABC) transporter
HUE69_RS08730	COG1846	Transcriptional regulator
HUE69_RS08735	COG1113	amino acid transport
HUE69_RS08745	COG0577	efflux transmembrane transporter activity
HUE69_RS08745	COG1136	(ABC) transporter
HUE69_RS08750	COG1113	amino acid transport
HUE69_RS08780	COG0588	phosphoglycerate mutase activity
HUE69_RS08790	COG0778	Nitroreductase
HUE69_RS08840	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HUE69_RS08845	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HUE69_RS08850	COG0366	Alpha amylase catalytic
HUE69_RS08855	COG0395	ABC-type sugar transport system, permease component
HUE69_RS08860	COG1175	transmembrane transport
HUE69_RS08880	COG0590	tRNA wobble adenosine to inosine editing
HUE69_RS08880	COG0037	tRNA processing
HUE69_RS08885	COG0025	NhaP-type Na H and K H
HUE69_RS08915	COG3833	ABC-type maltose transport systems, permease component
HUE69_RS08920	COG1175	transmembrane transport
HUE69_RS08925	COG1653	transport
HUE69_RS08930	COG1486	melibiose metabolic process
HUE69_RS08935	COG1349	DNA-binding transcription factor activity
HUE69_RS08965	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HUE69_RS08975	COG1263	PTS System
HUE69_RS08975	COG2190	(PTS) system
HUE69_RS08975	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HUE69_RS08980	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HUE69_RS08980	COG1263	PTS System
HUE69_RS08990	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HUE69_RS09000	COG3842	ATPase activity
HUE69_RS09005	COG1215	transferase activity, transferring glycosyl groups
HUE69_RS09015	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HUE69_RS09040	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HUE69_RS09065	COG3583	domain protein
HUE69_RS09085	COG0617	tRNA 3'-terminal CCA addition
HUE69_RS09110	COG1475	DNA binding
HUE69_RS09115	COG1192	Involved in chromosome partitioning
HUE69_RS09155	COG0592	DNA-directed DNA polymerase activity
HUE69_RS09170	COG0187	DNA topoisomerase II activity
HUE69_RS09175	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HUE69_RS09180	COG3266	domain, Protein
HUE69_RS09185	COG0542	response to heat
HUE69_RS09195	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HUE69_RS09245	COG3639	organic phosphonate transmembrane transporter activity
HUE69_RS09260	COG1737	Transcriptional regulator
HUE69_RS09285	COG0783	Belongs to the Dps family
HUE69_RS09290	COG1253	flavin adenine dinucleotide binding
HUE69_RS09300	COG0842	Transport permease protein
HUE69_RS09300	COG1716	ATPase activity
HUE69_RS09300	COG1131	(ABC) transporter
HUE69_RS09335	COG1373	ATPase (AAA superfamily
HUE69_RS09350	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HUE69_RS09370	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HUE69_RS09385	COG0180	Tryptophanyl-tRNA synthetase
HUE69_RS09395	COG2197	response regulator
HUE69_RS09415	COG0058	SHG alpha-glucan phosphorylase activity
HUE69_RS09455	COG0515	serine threonine protein kinase
HUE69_RS09460	COG0768	penicillin binding
HUE69_RS09505	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HUE69_RS09510	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HUE69_RS09510	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HUE69_RS09540	COG0071	Belongs to the small heat shock protein (HSP20) family
HUE69_RS09580	COG0343	queuine tRNA-ribosyltransferase activity
HUE69_RS09600	COG0559	Belongs to the binding-protein-dependent transport system permease family
HUE69_RS09620	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HUE69_RS09630	COG0804	urea catabolic process
HUE69_RS09645	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HUE69_RS09690	COG2226	methyltransferase
HUE69_RS09695	COG4974	Belongs to the 'phage' integrase family
HUE69_RS09705	COG2188	Transcriptional regulator
HUE69_RS09710	COG1397	ADP-ribosylglycohydrolase
HUE69_RS09715	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HUE69_RS09715	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HUE69_RS09740	COG0191	fructose-bisphosphate aldolase activity
HUE69_RS09790	COG0477	Major facilitator Superfamily
HUE69_RS09810	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HUE69_RS09815	COG1122	ATPase activity
HUE69_RS09820	COG1268	BioY protein
HUE69_RS09885	COG0789	Transcriptional regulator
HUE69_RS09910	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HUE69_RS09915	COG0586	Pfam SNARE associated Golgi protein
HUE69_RS09990	COG0527	aspartate kinase activity
HUE69_RS10030	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HUE69_RS10030	COG1754	DNA topoisomerase type I activity
HUE69_RS10060	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HUE69_RS10110	COG3152	Membrane
HUE69_RS10135	COG3619	membrane
HUE69_RS10155	COG0672	)-iron permease
HUE69_RS10160	COG3470	protein probably involved in high-affinity Fe2 transport
HUE69_RS10175	COG0577	efflux transmembrane transporter activity
HUE69_RS10180	COG1136	(ABC) transporter
HUE69_RS10210	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HUE69_RS10215	COG0363	glucosamine-6-phosphate deaminase activity
HUE69_RS10250	COG1216	Glycosyl transferase, family 2
HUE69_RS10255	COG1309	transcriptional regulator
HUE69_RS10280	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HUE69_RS10290	COG0305	Participates in initiation and elongation during chromosome replication
HUE69_RS10295	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HUE69_RS10315	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HUE69_RS10360	COG1131	(ABC) transporter
HUE69_RS10370	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HUE69_RS10410	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HUE69_RS10420	COG1937	Protein conserved in bacteria
HUE69_RS10425	COG1322	Protein conserved in bacteria
HUE69_RS10510	COG0745	RESPONSE REGULATOR receiver
HUE69_RS10525	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HUE69_RS10575	COG0582	viral genome integration into host DNA
HUE69_RS10655	COG0356	it plays a direct role in the translocation of protons across the membrane
HUE69_RS10690	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HUE69_RS10700	COG0545	Peptidyl-prolyl cis-trans isomerase
HUE69_RS10750	COG0251	oxidation-reduction process
HUE69_RS10785	COG3842	ATPase activity
HUE69_RS10800	COG1027	Aspartate ammonia-lyase
HUE69_RS10815	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HUE69_RS10865	COG2270	Major facilitator Superfamily
HUE69_RS10870	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HUE69_RS10870	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HUE69_RS10900	COG1301	dicarboxylic acid transport
HUE69_RS10905	COG0742	ribosomal rna small subunit methyltransferase
HUE69_RS10915	COG0826	peptidase U32
HUE69_RS10920	COG1496	oxidoreductase activity
HUE69_RS10930	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HUE69_RS10940	COG3579	cysteine-type endopeptidase activity
HUE69_RS10945	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HUE69_RS10950	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HUE69_RS10955	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HUE69_RS10960	COG0477	Major facilitator Superfamily
HUE69_RS10965	COG5002	protein histidine kinase activity
HUE69_RS10970	COG0745	RESPONSE REGULATOR receiver
HUE69_RS10995	COG1704	LemA family
HUE69_RS11020	COG1957	nucleoside hydrolase
HUE69_RS11045	COG1837	Belongs to the UPF0109 family
HUE69_RS11075	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HUE69_RS11075	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HUE69_RS11105	COG0505	Belongs to the CarA family
HUE69_RS11125	COG1487	ribonuclease activity
HUE69_RS11135	COG0440	acetolactate synthase activity
HUE69_RS11175	COG0667	Aldo Keto reductase
HUE69_RS11220	COG2348	transferase activity, transferring amino-acyl groups
HUE69_RS11250	COG1116	anion transmembrane transporter activity
HUE69_RS11270	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HUE69_RS11275	COG1609	Transcriptional regulator
HUE69_RS11310	COG2814	Major facilitator Superfamily
HUE69_RS11335	COG1136	(ABC) transporter
HUE69_RS11385	COG2814	Major facilitator Superfamily
HUE69_RS11465	COG0577	efflux transmembrane transporter activity