locus-tag	class	description
LDH93_RS00025	COG3328	transposase activity
LDH93_RS00105	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LDH93_RS00110	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LDH93_RS00125	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LDH93_RS00125	COG1754	DNA topoisomerase type I activity
LDH93_RS00140	COG1260	myo-inositol-1-phosphate synthase
LDH93_RS00145	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LDH93_RS00165	COG0527	aspartate kinase activity
LDH93_RS00225	COG0494	nUDIX hydrolase
LDH93_RS00225	COG0406	alpha-ribazole phosphatase activity
LDH93_RS00240	COG2261	transglycosylase associated protein
LDH93_RS00245	COG2261	transglycosylase associated protein
LDH93_RS00255	COG0584	glycerophosphoryl diester phosphodiesterase
LDH93_RS00275	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LDH93_RS00280	COG0305	Participates in initiation and elongation during chromosome replication
LDH93_RS00285	COG1573	uracil-dna glycosylase
LDH93_RS00290	COG1573	uracil-dna glycosylase
LDH93_RS00295	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
LDH93_RS00315	COG1309	transcriptional regulator
LDH93_RS00335	COG1129	ABC transporter
LDH93_RS00370	COG0671	phosphoesterase, PA-phosphatase related
LDH93_RS00380	COG0346	lactoylglutathione lyase activity
LDH93_RS00405	COG1846	Transcriptional regulator
LDH93_RS00410	COG1113	amino acid transport
LDH93_RS00430	COG1113	amino acid transport
LDH93_RS00440	COG3459	Glycosyltransferase 36 associated
LDH93_RS00465	COG1609	Transcriptional regulator
LDH93_RS00475	COG1401	restriction endodeoxyribonuclease activity
LDH93_RS00505	COG2226	methyltransferase
LDH93_RS00525	COG0477	Major facilitator Superfamily
LDH93_RS00550	COG2315	Protein conserved in bacteria
LDH93_RS00575	COG0191	fructose-bisphosphate aldolase activity
LDH93_RS00600	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LDH93_RS00615	COG2814	Major facilitator Superfamily
LDH93_RS00660	COG0343	queuine tRNA-ribosyltransferase activity
LDH93_RS00675	COG2226	methyltransferase
LDH93_RS00685	COG0697	spore germination
LDH93_RS00720	COG0768	penicillin binding
LDH93_RS00725	COG0515	serine threonine protein kinase
LDH93_RS00740	COG3764	Sortase (surface protein transpeptidase)
LDH93_RS00775	COG0058	SHG alpha-glucan phosphorylase activity
LDH93_RS00790	COG0180	Tryptophanyl-tRNA synthetase
LDH93_RS00800	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
LDH93_RS00840	COG4214	carbohydrate transport
LDH93_RS00850	COG1609	Transcriptional regulator
LDH93_RS00855	COG0288	reversible hydration of carbon dioxide
LDH93_RS00865	COG1253	flavin adenine dinucleotide binding
LDH93_RS00870	COG0783	Belongs to the Dps family
LDH93_RS00880	COG0366	Alpha amylase catalytic
LDH93_RS00960	COG3231	kanamycin kinase activity
LDH93_RS01005	COG2226	methyltransferase
LDH93_RS01010	COG0596	Alpha beta hydrolase
LDH93_RS01090	COG1970	mechanosensitive ion channel activity
LDH93_RS01100	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
LDH93_RS01105	COG1272	protein, Hemolysin III
LDH93_RS01125	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LDH93_RS01130	COG0187	DNA topoisomerase II activity
LDH93_RS01145	COG0592	DNA-directed DNA polymerase activity
LDH93_RS01175	COG1847	R3H domain protein
LDH93_RS01185	COG1192	Involved in chromosome partitioning
LDH93_RS01200	COG0492	ferredoxin-NADP+ reductase activity
LDH93_RS01210	COG1957	nucleoside hydrolase
LDH93_RS01240	COG0617	tRNA 3'-terminal CCA addition
LDH93_RS01260	COG3583	domain protein
LDH93_RS01280	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LDH93_RS01285	COG3842	ATPase activity
LDH93_RS01295	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LDH93_RS01300	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LDH93_RS01305	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LDH93_RS01305	COG0596	Alpha beta hydrolase
LDH93_RS01305	COG2226	methyltransferase
LDH93_RS01320	COG0025	NhaP-type Na H and K H
LDH93_RS01325	COG0590	tRNA wobble adenosine to inosine editing
LDH93_RS01325	COG0037	tRNA processing
LDH93_RS01345	COG1175	transmembrane transport
LDH93_RS01350	COG0395	ABC-type sugar transport system, permease component
LDH93_RS01365	COG0366	Alpha amylase catalytic
LDH93_RS01380	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LDH93_RS01385	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
LDH93_RS01405	COG0477	Major facilitator Superfamily
LDH93_RS01410	COG3177	Filamentation induced by cAMP protein fic
LDH93_RS01445	COG0778	Nitroreductase
LDH93_RS01460	COG0366	Alpha amylase catalytic
LDH93_RS01465	COG2182	Extracellular solute-binding protein
LDH93_RS01470	COG1609	Transcriptional regulator
LDH93_RS01490	COG3328	transposase activity
LDH93_RS01530	COG3328	transposase activity
LDH93_RS01550	COG1175	transmembrane transport
LDH93_RS01555	COG3833	ABC-type maltose transport systems, permease component
LDH93_RS01560	COG1523	belongs to the glycosyl hydrolase 13 family
LDH93_RS01575	COG1609	Transcriptional regulator
LDH93_RS01590	COG0484	heat shock protein binding
LDH93_RS01595	COG0789	Transcriptional regulator
LDH93_RS01600	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LDH93_RS01605	COG1472	Belongs to the glycosyl hydrolase 3 family
LDH93_RS01620	COG1609	Transcriptional regulator
LDH93_RS01635	COG0586	Pfam SNARE associated Golgi protein
LDH93_RS01680	COG1132	(ABC) transporter
LDH93_RS01695	COG0084	hydrolase, TatD family'
LDH93_RS01725	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LDH93_RS01740	COG1216	Glycosyl transferase, family 2
LDH93_RS01760	COG1216	Glycosyl transferase, family 2
LDH93_RS01795	COG1216	Glycosyl transferase, family 2
LDH93_RS01800	COG1368	sulfuric ester hydrolase activity
LDH93_RS01825	COG3594	Acyltransferase
LDH93_RS01895	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LDH93_RS01910	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
LDH93_RS01920	COG2826	transposase and inactivated derivatives, IS30 family
LDH93_RS01940	COG0179	Fumarylacetoacetate (FAA) hydrolase
LDH93_RS01950	COG2217	Heavy metal translocating P-type atpase
LDH93_RS01970	COG1131	(ABC) transporter
LDH93_RS02015	COG1522	sequence-specific DNA binding
LDH93_RS02035	COG0747	negative chemotaxis
LDH93_RS02045	COG0745	RESPONSE REGULATOR receiver
LDH93_RS02055	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
LDH93_RS02075	COG0028	Belongs to the TPP enzyme family
LDH93_RS02080	COG0679	Auxin Efflux Carrier
LDH93_RS02100	COG0356	it plays a direct role in the translocation of protons across the membrane
LDH93_RS02135	COG0355	proton-transporting ATP synthase activity, rotational mechanism
LDH93_RS02145	COG0545	Peptidyl-prolyl cis-trans isomerase
LDH93_RS02175	COG0251	oxidation-reduction process
LDH93_RS02185	COG0019	diaminopimelate decarboxylase activity
LDH93_RS02190	COG0460	homoserine dehydrogenase
LDH93_RS02195	COG0083	homoserine kinase activity
LDH93_RS02200	COG0489	protein tyrosine kinase activity
LDH93_RS02210	COG0366	Alpha amylase catalytic
LDH93_RS02215	COG0366	Alpha amylase catalytic
LDH93_RS02220	COG0366	Alpha amylase catalytic
LDH93_RS02225	COG1216	Glycosyl transferase, family 2
LDH93_RS02230	COG5039	Polysaccharide pyruvyl transferase
LDH93_RS02245	COG0463	Glycosyl transferase, family 2
LDH93_RS02295	COG1216	Glycosyl transferase, family 2
LDH93_RS02300	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LDH93_RS02320	COG1132	(ABC) transporter
LDH93_RS02365	COG2814	Major facilitator Superfamily
LDH93_RS02375	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LDH93_RS02400	COG1216	Glycosyl transferase, family 2
LDH93_RS02430	COG1088	dTDP-glucose 4,6-dehydratase activity
LDH93_RS02460	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LDH93_RS02470	COG2267	carboxylic ester hydrolase activity
LDH93_RS02500	COG2314	TM2 domain
LDH93_RS02510	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LDH93_RS02515	COG4499	WXG100 protein secretion system (Wss), protein YukC
LDH93_RS02515	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LDH93_RS02520	COG1902	pentaerythritol trinitrate reductase activity
LDH93_RS02525	COG0167	dihydroorotate dehydrogenase activity
LDH93_RS02530	COG0463	Glycosyl transferase, family 2
LDH93_RS02535	COG1349	DNA-binding transcription factor activity
LDH93_RS02545	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
LDH93_RS02565	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
LDH93_RS02570	COG1194	a g-specific adenine glycosylase
LDH93_RS02620	COG0714	Associated with various cellular activities
LDH93_RS02640	COG0210	DNA helicase
LDH93_RS02665	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
LDH93_RS02690	COG3579	cysteine-type endopeptidase activity
LDH93_RS02695	COG0531	amino acid
LDH93_RS02715	COG0436	Aminotransferase
LDH93_RS02720	COG0248	Ppx GppA phosphatase
LDH93_RS02740	COG1722	exodeoxyribonuclease VII activity
LDH93_RS02745	COG1570	exodeoxyribonuclease VII activity
LDH93_RS02750	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
LDH93_RS02750	COG1328	CTP reductase activity
LDH93_RS02765	COG1924	4 iron, 4 sulfur cluster binding
LDH93_RS02835	COG1132	(ABC) transporter
LDH93_RS02840	COG1132	(ABC) transporter
LDH93_RS02865	COG2365	Tyrosine phosphatase family
LDH93_RS02885	COG1842	Phage shock protein A
LDH93_RS02890	COG2814	Major facilitator Superfamily
LDH93_RS02895	COG4166	transmembrane transport
LDH93_RS02945	COG2176	DNA-directed DNA polymerase activity
LDH93_RS02955	COG0531	amino acid
LDH93_RS02960	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
LDH93_RS02970	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LDH93_RS02975	COG2011	ABC-type metal ion transport system permease component
LDH93_RS02980	COG0436	Aminotransferase
LDH93_RS02985	COG0765	amino acid transport
LDH93_RS02990	COG0765	amino acid transport
LDH93_RS02995	COG1126	abc transporter atp-binding protein
LDH93_RS03020	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
LDH93_RS03055	COG3480	Lon protease (S16) C-terminal proteolytic domain
LDH93_RS03120	COG1957	nucleoside hydrolase
LDH93_RS03130	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LDH93_RS03140	COG2826	transposase and inactivated derivatives, IS30 family
LDH93_RS03215	COG0587	DNA-directed DNA polymerase activity
LDH93_RS03255	COG0174	glutamine synthetase
LDH93_RS03270	COG2813	Specifically methylates the guanine in position
LDH93_RS03275	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LDH93_RS03295	COG3858	chitin binding
LDH93_RS03295	COG1388	LysM domain
LDH93_RS03305	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LDH93_RS03330	COG0768	penicillin binding
LDH93_RS03340	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LDH93_RS03380	COG3250	beta-galactosidase activity
LDH93_RS03385	COG1609	Transcriptional regulator
LDH93_RS03430	COG1940	carbohydrate kinase activity
LDH93_RS03440	COG0601	transmembrane transport
LDH93_RS03460	COG2816	NAD+ diphosphatase activity
LDH93_RS03465	COG0006	proline dipeptidase activity
LDH93_RS03490	COG0285	dihydrofolate synthase activity
LDH93_RS03520	COG2017	converts alpha-aldose to the beta-anomer
LDH93_RS03530	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LDH93_RS03545	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
LDH93_RS03575	COG0477	Major facilitator Superfamily
LDH93_RS03580	COG1217	gtp-binding protein TYPA
LDH93_RS03595	COG0287	Prephenate dehydrogenase
LDH93_RS03605	COG1929	Belongs to the glycerate kinase type-1 family
LDH93_RS03610	COG0577	efflux transmembrane transporter activity
LDH93_RS03615	COG4591	ABC-type transport system involved in lipoprotein release permease component
LDH93_RS03615	COG1136	(ABC) transporter
LDH93_RS03625	COG4166	transmembrane transport
LDH93_RS03630	COG0601	transmembrane transport
LDH93_RS03635	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LDH93_RS03650	COG0708	Exodeoxyribonuclease III
LDH93_RS03680	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
LDH93_RS03690	COG1335	isochorismatase
LDH93_RS03700	COG2826	transposase and inactivated derivatives, IS30 family
LDH93_RS03715	COG1131	(ABC) transporter
LDH93_RS03720	COG4585	Histidine kinase
LDH93_RS03725	COG2197	response regulator
LDH93_RS03730	COG0670	Belongs to the BI1 family
LDH93_RS03735	COG2357	RelA SpoT domain protein
LDH93_RS03755	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LDH93_RS03760	COG1546	Belongs to the CinA family
LDH93_RS03760	COG1058	Belongs to the CinA family
LDH93_RS03765	COG1396	sequence-specific DNA binding
LDH93_RS03790	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
LDH93_RS03800	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LDH93_RS03820	COG0142	geranyltranstransferase activity
LDH93_RS03830	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LDH93_RS03835	COG0187	DNA topoisomerase II activity
LDH93_RS03860	COG1201	RNA secondary structure unwinding
LDH93_RS03865	COG4975	Glucose uptake
LDH93_RS03870	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LDH93_RS03895	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LDH93_RS03900	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LDH93_RS03905	COG0561	phosphatase activity
LDH93_RS03910	COG1464	Belongs to the NlpA lipoprotein family
LDH93_RS03920	COG2011	ABC-type metal ion transport system permease component
LDH93_RS03925	COG1473	amidohydrolase
LDH93_RS03930	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
LDH93_RS03930	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LDH93_RS03940	COG1882	Formate acetyltransferase
LDH93_RS03945	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
LDH93_RS04000	COG1611	Belongs to the LOG family
LDH93_RS04010	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
LDH93_RS04015	COG1053	succinate dehydrogenase
LDH93_RS04020	COG0758	DNA mediated transformation
LDH93_RS04020	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LDH93_RS04035	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
LDH93_RS04040	COG2873	o-acetylhomoserine
LDH93_RS04045	COG1122	ATPase activity
LDH93_RS04055	COG1136	(ABC) transporter
LDH93_RS04055	COG0577	efflux transmembrane transporter activity
LDH93_RS04065	COG2197	response regulator
LDH93_RS04070	COG4585	Histidine kinase
LDH93_RS04080	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
LDH93_RS04085	COG0012	GTP binding
LDH93_RS04105	COG2233	PERMEase
LDH93_RS04110	COG0513	Belongs to the DEAD box helicase family
LDH93_RS04115	COG1028	Short-chain dehydrogenase reductase Sdr
LDH93_RS04140	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
LDH93_RS04165	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
LDH93_RS04165	COG1918	ferrous iron import across plasma membrane
LDH93_RS04175	COG1027	Aspartate ammonia-lyase
LDH93_RS04205	COG4552	Acetyltransferase involved in intracellular survival and related
LDH93_RS04220	COG1966	Carbon starvation protein
LDH93_RS04240	COG1247	-acetyltransferase
LDH93_RS04285	COG1760	l-serine dehydratase
LDH93_RS04295	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LDH93_RS04315	COG1674	ftsk spoiiie
LDH93_RS04320	COG1316	TRANSCRIPTIONal
LDH93_RS04325	COG1316	TRANSCRIPTIONal
LDH93_RS04355	COG2205	protein histidine kinase activity
LDH93_RS04360	COG0745	RESPONSE REGULATOR receiver
LDH93_RS04370	COG1329	Transcriptional regulator
LDH93_RS04380	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LDH93_RS04385	COG1121	(ABC) transporter
LDH93_RS04400	COG0539	negative regulation of cytoplasmic translation
LDH93_RS04405	COG0237	dephospho-CoA kinase activity
LDH93_RS04420	COG0469	pyruvate kinase activity
LDH93_RS04430	COG3655	Transcriptional regulator
LDH93_RS04480	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LDH93_RS04485	COG0857	belongs to the CobB CobQ family
LDH93_RS04485	COG0280	phosphate acetyltransferase
LDH93_RS04520	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LDH93_RS04525	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
LDH93_RS04610	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
LDH93_RS04645	COG1523	belongs to the glycosyl hydrolase 13 family
LDH93_RS04670	COG1136	(ABC) transporter
LDH93_RS04670	COG0577	efflux transmembrane transporter activity
LDH93_RS04695	COG1376	ErfK ybiS ycfS ynhG family protein
LDH93_RS04710	COG0396	ATPase activity
LDH93_RS04725	COG2151	metal-sulfur cluster biosynthetic enzyme
LDH93_RS04735	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LDH93_RS04745	COG0537	adenosine 5'-monophosphoramidase activity
LDH93_RS04775	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
LDH93_RS04800	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LDH93_RS04805	COG2860	membrane
LDH93_RS04825	COG0070	glutamate synthase
LDH93_RS04825	COG0069	glutamate synthase activity
LDH93_RS04825	COG0067	glutamate synthase
LDH93_RS04845	COG1119	ATPase activity
LDH93_RS04865	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
LDH93_RS04885	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LDH93_RS04890	COG0284	orotidine-5'-phosphate decarboxylase activity
LDH93_RS04900	COG0167	dihydroorotate dehydrogenase activity
LDH93_RS04940	COG0583	DNA-binding transcription factor activity
LDH93_RS04950	COG0492	ferredoxin-NADP+ reductase activity
LDH93_RS04955	COG0450	alkyl hydroperoxide reductase
LDH93_RS04980	COG0488	(ABC) transporter
LDH93_RS05005	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LDH93_RS05030	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LDH93_RS05035	COG0561	phosphatase activity
LDH93_RS05040	COG0436	Aminotransferase
LDH93_RS05050	COG0436	Aminotransferase
LDH93_RS05055	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LDH93_RS05120	COG1131	(ABC) transporter
LDH93_RS05155	COG0488	(ABC) transporter
LDH93_RS05180	COG0438	transferase activity, transferring glycosyl groups
LDH93_RS05205	COG1862	Preprotein translocase
LDH93_RS05215	COG0045	succinate-CoA ligase (ADP-forming) activity
LDH93_RS05240	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LDH93_RS05275	COG4581	dead DEAH box helicase
LDH93_RS05300	COG1716	ATPase activity
LDH93_RS05320	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LDH93_RS05335	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LDH93_RS05405	COG4589	Belongs to the CDS family
LDH93_RS05435	COG1022	Amp-dependent synthetase and ligase
LDH93_RS05445	COG0516	GMP reductase activity
LDH93_RS05500	COG0802	atpase or kinase
LDH93_RS05530	COG0598	Magnesium transport protein CorA
LDH93_RS05535	COG0406	alpha-ribazole phosphatase activity
LDH93_RS05560	COG0588	phosphoglycerate mutase activity
LDH93_RS05565	COG0799	negative regulation of ribosome biogenesis
LDH93_RS05585	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
LDH93_RS05605	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LDH93_RS05610	COG0497	DNA recombination
LDH93_RS05620	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LDH93_RS05625	COG0569	domain protein
LDH93_RS05710	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LDH93_RS05715	COG0577	efflux transmembrane transporter activity
LDH93_RS05720	COG1136	(ABC) transporter
LDH93_RS05730	COG4721	ABC-type cobalt transport system, permease component
LDH93_RS05740	COG1136	(ABC) transporter
LDH93_RS05770	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LDH93_RS05780	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LDH93_RS05850	COG2151	metal-sulfur cluster biosynthetic enzyme
LDH93_RS05850	COG0489	protein tyrosine kinase activity
LDH93_RS05885	COG1122	ATPase activity
LDH93_RS05910	COG0656	L-ascorbic acid biosynthetic process
LDH93_RS05920	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
LDH93_RS05925	COG3304	Inner membrane component domain
LDH93_RS05950	COG1022	Amp-dependent synthetase and ligase
LDH93_RS05955	COG2814	Major facilitator Superfamily
LDH93_RS05970	COG2326	polyphosphate kinase activity
LDH93_RS05975	COG0765	amino acid transport
LDH93_RS05980	COG0765	amino acid transport
LDH93_RS05985	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LDH93_RS05990	COG1126	abc transporter atp-binding protein
LDH93_RS06010	COG1196	nuclear chromosome segregation
LDH93_RS06015	COG0542	response to heat
LDH93_RS06020	COG0589	response to stress
LDH93_RS06035	COG1278	Cold shock
LDH93_RS06040	COG2205	protein histidine kinase activity
LDH93_RS06045	COG0745	RESPONSE REGULATOR receiver
LDH93_RS06065	COG1278	Cold shock
LDH93_RS06080	COG0714	Associated with various cellular activities
LDH93_RS06120	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LDH93_RS06155	COG1222	aaa ATPase
LDH93_RS06160	COG0586	Pfam SNARE associated Golgi protein
LDH93_RS06165	COG0560	Phosphoserine phosphatase
LDH93_RS06175	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LDH93_RS06180	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LDH93_RS06205	COG0284	orotidine-5'-phosphate decarboxylase activity
LDH93_RS06285	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LDH93_RS06345	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LDH93_RS06360	COG0151	Belongs to the GarS family
LDH93_RS06365	COG0477	Major facilitator Superfamily
LDH93_RS06380	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
LDH93_RS06385	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
LDH93_RS06395	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
LDH93_RS06400	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
LDH93_RS06410	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LDH93_RS06435	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
LDH93_RS06440	COG0358	DNA primase activity
LDH93_RS06450	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LDH93_RS06465	COG0371	Dehydrogenase
LDH93_RS06475	COG0514	ATP-dependent DNA helicase (RecQ)
LDH93_RS06495	COG4608	Belongs to the ABC transporter superfamily
LDH93_RS06500	COG0444	Belongs to the ABC transporter superfamily
LDH93_RS06505	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LDH93_RS06510	COG0601	transmembrane transport
LDH93_RS06515	COG4166	transmembrane transport
LDH93_RS06525	COG1653	transport
LDH93_RS06540	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LDH93_RS06545	COG2197	response regulator
LDH93_RS06555	COG0765	amino acid transport
LDH93_RS06560	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LDH93_RS06625	COG1971	Probably functions as a manganese efflux pump
LDH93_RS06650	COG1388	LysM domain
LDH93_RS06650	COG3942	CHAP domain
LDH93_RS06655	COG2177	Part of the ABC transporter FtsEX involved in
LDH93_RS06660	COG2884	Cell division ATP-binding protein ftsE
LDH93_RS06665	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
LDH93_RS06680	COG0372	Belongs to the citrate synthase family
LDH93_RS06695	COG3590	peptidase
LDH93_RS06715	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LDH93_RS06720	COG0561	phosphatase activity
LDH93_RS06745	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LDH93_RS06750	COG0009	L-threonylcarbamoyladenylate synthase
LDH93_RS06785	COG1940	carbohydrate kinase activity
LDH93_RS06790	COG1070	Carbohydrate kinase
LDH93_RS06800	COG2272	Belongs to the type-B carboxylesterase lipase family
LDH93_RS06810	COG3507	Belongs to the glycosyl hydrolase 43 family
LDH93_RS06820	COG1175	transmembrane transport
LDH93_RS06830	COG1609	Transcriptional regulator
LDH93_RS06840	COG3507	Belongs to the glycosyl hydrolase 43 family
LDH93_RS06850	COG2249	NAD(P)H dehydrogenase (quinone) activity
LDH93_RS06870	COG2873	o-acetylhomoserine
LDH93_RS06885	COG1946	Acyl-CoA thioesterase
LDH93_RS06900	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LDH93_RS06930	COG1215	transferase activity, transferring glycosyl groups
LDH93_RS06935	COG0628	permease
LDH93_RS06940	COG1216	Glycosyl transferase, family 2
LDH93_RS06945	COG0789	Transcriptional regulator
LDH93_RS06980	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
LDH93_RS06985	COG0531	amino acid
LDH93_RS06995	COG1454	alcohol dehydrogenase
LDH93_RS07015	COG1397	ADP-ribosylglycohydrolase
LDH93_RS07045	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LDH93_RS07055	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
LDH93_RS07060	COG4721	ABC-type cobalt transport system, permease component
LDH93_RS07065	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LDH93_RS07070	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
LDH93_RS07085	COG0589	response to stress
LDH93_RS07090	COG1388	LysM domain
LDH93_RS07090	COG3103	Sh3 type 3 domain protein
LDH93_RS07090	COG0791	NLP P60 protein
LDH93_RS07095	COG1388	LysM domain
LDH93_RS07095	COG3942	CHAP domain
LDH93_RS07100	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
LDH93_RS07115	COG5002	protein histidine kinase activity
LDH93_RS07130	COG4716	Myosin-crossreactive antigen
LDH93_RS07145	COG0300	oxidoreductase activity
LDH93_RS07155	COG0559	Belongs to the binding-protein-dependent transport system permease family
LDH93_RS07165	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
LDH93_RS07175	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LDH93_RS07195	COG0626	cystathionine gamma-synthase activity
LDH93_RS07200	COG0390	transport system, permease component
LDH93_RS07205	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
LDH93_RS07225	COG2197	response regulator
LDH93_RS07260	COG1597	lipid kinase activity
LDH93_RS07260	COG1803	Methylglyoxal synthase
LDH93_RS07275	COG0328	RNA-DNA hybrid ribonuclease activity
LDH93_RS07300	COG0196	riboflavin kinase activity
LDH93_RS07435	COG0255	Belongs to the universal ribosomal protein uL29 family
LDH93_RS07495	COG1012	belongs to the aldehyde dehydrogenase family
LDH93_RS07495	COG1454	alcohol dehydrogenase
LDH93_RS07540	COG1739	Uncharacterized protein family UPF0029
LDH93_RS07555	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LDH93_RS07570	COG0531	amino acid
LDH93_RS07575	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LDH93_RS07615	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LDH93_RS07660	COG2252	PERMEase
LDH93_RS07670	COG0581	inorganic phosphate transmembrane transporter activity
LDH93_RS07685	COG0745	RESPONSE REGULATOR receiver
LDH93_RS07690	COG5002	protein histidine kinase activity
LDH93_RS07695	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
LDH93_RS07700	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LDH93_RS07705	COG2755	lipolytic protein G-D-S-L family
LDH93_RS07705	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LDH93_RS07710	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LDH93_RS07715	COG3579	cysteine-type endopeptidase activity
LDH93_RS07740	COG0826	peptidase U32
LDH93_RS07760	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LDH93_RS07780	COG1704	LemA family
LDH93_RS07795	COG0039	L-malate dehydrogenase activity
LDH93_RS07820	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LDH93_RS07825	COG4770	biotin carboxylase activity
LDH93_RS07875	COG0436	Aminotransferase
LDH93_RS07945	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LDH93_RS07965	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LDH93_RS08035	COG0667	Aldo Keto reductase
LDH93_RS08085	COG0488	(ABC) transporter
LDH93_RS08140	COG1837	Belongs to the UPF0109 family
LDH93_RS08155	COG0742	ribosomal rna small subunit methyltransferase
LDH93_RS08160	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LDH93_RS08170	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
LDH93_RS08170	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
LDH93_RS08185	COG0436	Aminotransferase
LDH93_RS08245	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LDH93_RS08355	COG0366	Alpha amylase catalytic