locus-tag	class	description
LDX61_RS00025	COG3328	transposase activity
LDX61_RS00105	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LDX61_RS00110	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LDX61_RS00125	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LDX61_RS00125	COG1754	DNA topoisomerase type I activity
LDX61_RS00140	COG1260	myo-inositol-1-phosphate synthase
LDX61_RS00145	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LDX61_RS00165	COG0527	aspartate kinase activity
LDX61_RS00225	COG0494	nUDIX hydrolase
LDX61_RS00225	COG0406	alpha-ribazole phosphatase activity
LDX61_RS00240	COG2261	transglycosylase associated protein
LDX61_RS00245	COG2261	transglycosylase associated protein
LDX61_RS00275	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LDX61_RS00280	COG0305	Participates in initiation and elongation during chromosome replication
LDX61_RS00285	COG1573	uracil-dna glycosylase
LDX61_RS00290	COG1573	uracil-dna glycosylase
LDX61_RS00295	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
LDX61_RS00315	COG1309	transcriptional regulator
LDX61_RS00335	COG1129	ABC transporter
LDX61_RS00370	COG0671	phosphoesterase, PA-phosphatase related
LDX61_RS00380	COG0346	lactoylglutathione lyase activity
LDX61_RS00405	COG1846	Transcriptional regulator
LDX61_RS00410	COG1113	amino acid transport
LDX61_RS00430	COG1113	amino acid transport
LDX61_RS00440	COG3459	Glycosyltransferase 36 associated
LDX61_RS00465	COG1609	Transcriptional regulator
LDX61_RS00475	COG1401	restriction endodeoxyribonuclease activity
LDX61_RS00505	COG2226	methyltransferase
LDX61_RS00525	COG0477	Major facilitator Superfamily
LDX61_RS00550	COG2315	Protein conserved in bacteria
LDX61_RS00575	COG0191	fructose-bisphosphate aldolase activity
LDX61_RS00600	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LDX61_RS00615	COG2814	Major facilitator Superfamily
LDX61_RS00660	COG0343	queuine tRNA-ribosyltransferase activity
LDX61_RS00675	COG2226	methyltransferase
LDX61_RS00685	COG0697	spore germination
LDX61_RS00720	COG0768	penicillin binding
LDX61_RS00725	COG0515	serine threonine protein kinase
LDX61_RS00740	COG3764	Sortase (surface protein transpeptidase)
LDX61_RS00775	COG0058	SHG alpha-glucan phosphorylase activity
LDX61_RS00790	COG0180	Tryptophanyl-tRNA synthetase
LDX61_RS00800	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
LDX61_RS00840	COG4214	carbohydrate transport
LDX61_RS00850	COG1609	Transcriptional regulator
LDX61_RS00855	COG0288	reversible hydration of carbon dioxide
LDX61_RS00865	COG1253	flavin adenine dinucleotide binding
LDX61_RS00870	COG0783	Belongs to the Dps family
LDX61_RS00880	COG0366	Alpha amylase catalytic
LDX61_RS00960	COG3231	kanamycin kinase activity
LDX61_RS01005	COG2226	methyltransferase
LDX61_RS01010	COG0596	Alpha beta hydrolase
LDX61_RS01090	COG1970	mechanosensitive ion channel activity
LDX61_RS01100	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
LDX61_RS01105	COG1272	protein, Hemolysin III
LDX61_RS01125	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LDX61_RS01130	COG0187	DNA topoisomerase II activity
LDX61_RS01145	COG0592	DNA-directed DNA polymerase activity
LDX61_RS01175	COG1847	R3H domain protein
LDX61_RS01185	COG1192	Involved in chromosome partitioning
LDX61_RS01200	COG0492	ferredoxin-NADP+ reductase activity
LDX61_RS01210	COG1957	nucleoside hydrolase
LDX61_RS01240	COG0617	tRNA 3'-terminal CCA addition
LDX61_RS01260	COG3583	domain protein
LDX61_RS01280	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LDX61_RS01285	COG3842	ATPase activity
LDX61_RS01295	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LDX61_RS01300	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LDX61_RS01305	COG0596	Alpha beta hydrolase
LDX61_RS01305	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LDX61_RS01305	COG2226	methyltransferase
LDX61_RS01320	COG0025	NhaP-type Na H and K H
LDX61_RS01325	COG0037	tRNA processing
LDX61_RS01325	COG0590	tRNA wobble adenosine to inosine editing
LDX61_RS01345	COG1175	transmembrane transport
LDX61_RS01350	COG0395	ABC-type sugar transport system, permease component
LDX61_RS01365	COG0366	Alpha amylase catalytic
LDX61_RS01380	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LDX61_RS01385	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
LDX61_RS01405	COG0477	Major facilitator Superfamily
LDX61_RS01410	COG3177	Filamentation induced by cAMP protein fic
LDX61_RS01445	COG0778	Nitroreductase
LDX61_RS01460	COG0366	Alpha amylase catalytic
LDX61_RS01465	COG2182	Extracellular solute-binding protein
LDX61_RS01470	COG1609	Transcriptional regulator
LDX61_RS01490	COG3328	transposase activity
LDX61_RS01530	COG3328	transposase activity
LDX61_RS01550	COG1175	transmembrane transport
LDX61_RS01555	COG3833	ABC-type maltose transport systems, permease component
LDX61_RS01560	COG1523	belongs to the glycosyl hydrolase 13 family
LDX61_RS01575	COG1609	Transcriptional regulator
LDX61_RS01590	COG0484	heat shock protein binding
LDX61_RS01595	COG0789	Transcriptional regulator
LDX61_RS01600	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LDX61_RS01605	COG1472	Belongs to the glycosyl hydrolase 3 family
LDX61_RS01620	COG1609	Transcriptional regulator
LDX61_RS01635	COG0586	Pfam SNARE associated Golgi protein
LDX61_RS01680	COG1132	(ABC) transporter
LDX61_RS01695	COG0084	hydrolase, TatD family'
LDX61_RS01725	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LDX61_RS01740	COG1216	Glycosyl transferase, family 2
LDX61_RS01760	COG1216	Glycosyl transferase, family 2
LDX61_RS01795	COG1216	Glycosyl transferase, family 2
LDX61_RS01800	COG1368	sulfuric ester hydrolase activity
LDX61_RS01825	COG3594	Acyltransferase
LDX61_RS01895	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LDX61_RS01910	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
LDX61_RS01920	COG2826	transposase and inactivated derivatives, IS30 family
LDX61_RS01940	COG0179	Fumarylacetoacetate (FAA) hydrolase
LDX61_RS01950	COG2217	Heavy metal translocating P-type atpase
LDX61_RS01970	COG1131	(ABC) transporter
LDX61_RS02015	COG1522	sequence-specific DNA binding
LDX61_RS02035	COG0747	negative chemotaxis
LDX61_RS02045	COG0745	RESPONSE REGULATOR receiver
LDX61_RS02055	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
LDX61_RS02075	COG0028	Belongs to the TPP enzyme family
LDX61_RS02080	COG0679	Auxin Efflux Carrier
LDX61_RS02100	COG0356	it plays a direct role in the translocation of protons across the membrane
LDX61_RS02135	COG0355	proton-transporting ATP synthase activity, rotational mechanism
LDX61_RS02145	COG0545	Peptidyl-prolyl cis-trans isomerase
LDX61_RS02175	COG0251	oxidation-reduction process
LDX61_RS02185	COG0019	diaminopimelate decarboxylase activity
LDX61_RS02190	COG0460	homoserine dehydrogenase
LDX61_RS02195	COG0083	homoserine kinase activity
LDX61_RS02200	COG0489	protein tyrosine kinase activity
LDX61_RS02210	COG0366	Alpha amylase catalytic
LDX61_RS02215	COG0366	Alpha amylase catalytic
LDX61_RS02220	COG0366	Alpha amylase catalytic
LDX61_RS02225	COG1216	Glycosyl transferase, family 2
LDX61_RS02230	COG5039	Polysaccharide pyruvyl transferase
LDX61_RS02245	COG0463	Glycosyl transferase, family 2
LDX61_RS02295	COG1216	Glycosyl transferase, family 2
LDX61_RS02300	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LDX61_RS02320	COG1132	(ABC) transporter
LDX61_RS02365	COG2814	Major facilitator Superfamily
LDX61_RS02375	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LDX61_RS02400	COG1216	Glycosyl transferase, family 2
LDX61_RS02430	COG1088	dTDP-glucose 4,6-dehydratase activity
LDX61_RS02460	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LDX61_RS02470	COG2267	carboxylic ester hydrolase activity
LDX61_RS02500	COG2314	TM2 domain
LDX61_RS02510	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LDX61_RS02515	COG4499	WXG100 protein secretion system (Wss), protein YukC
LDX61_RS02515	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LDX61_RS02520	COG1902	pentaerythritol trinitrate reductase activity
LDX61_RS02525	COG0167	dihydroorotate dehydrogenase activity
LDX61_RS02530	COG0463	Glycosyl transferase, family 2
LDX61_RS02535	COG1349	DNA-binding transcription factor activity
LDX61_RS02545	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
LDX61_RS02565	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
LDX61_RS02570	COG1194	a g-specific adenine glycosylase
LDX61_RS02620	COG0714	Associated with various cellular activities
LDX61_RS02640	COG0210	DNA helicase
LDX61_RS02665	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
LDX61_RS02690	COG3579	cysteine-type endopeptidase activity
LDX61_RS02695	COG0531	amino acid
LDX61_RS02715	COG0436	Aminotransferase
LDX61_RS02720	COG0248	Ppx GppA phosphatase
LDX61_RS02740	COG1722	exodeoxyribonuclease VII activity
LDX61_RS02745	COG1570	exodeoxyribonuclease VII activity
LDX61_RS02750	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
LDX61_RS02750	COG1328	CTP reductase activity
LDX61_RS02765	COG1924	4 iron, 4 sulfur cluster binding
LDX61_RS02835	COG1132	(ABC) transporter
LDX61_RS02840	COG1132	(ABC) transporter
LDX61_RS02865	COG2365	Tyrosine phosphatase family
LDX61_RS02885	COG1842	Phage shock protein A
LDX61_RS02890	COG2814	Major facilitator Superfamily
LDX61_RS02895	COG4166	transmembrane transport
LDX61_RS02945	COG2176	DNA-directed DNA polymerase activity
LDX61_RS02955	COG0531	amino acid
LDX61_RS02960	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
LDX61_RS02970	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LDX61_RS02975	COG2011	ABC-type metal ion transport system permease component
LDX61_RS02980	COG0436	Aminotransferase
LDX61_RS02985	COG0765	amino acid transport
LDX61_RS02990	COG0765	amino acid transport
LDX61_RS02995	COG1126	abc transporter atp-binding protein
LDX61_RS03020	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
LDX61_RS03055	COG3480	Lon protease (S16) C-terminal proteolytic domain
LDX61_RS03120	COG1957	nucleoside hydrolase
LDX61_RS03130	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LDX61_RS03140	COG2826	transposase and inactivated derivatives, IS30 family
LDX61_RS03215	COG0587	DNA-directed DNA polymerase activity
LDX61_RS03255	COG0174	glutamine synthetase
LDX61_RS03270	COG2813	Specifically methylates the guanine in position
LDX61_RS03275	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LDX61_RS03295	COG1388	LysM domain
LDX61_RS03295	COG3858	chitin binding
LDX61_RS03305	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LDX61_RS03330	COG0768	penicillin binding
LDX61_RS03340	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LDX61_RS03380	COG3250	beta-galactosidase activity
LDX61_RS03385	COG1609	Transcriptional regulator
LDX61_RS03430	COG1940	carbohydrate kinase activity
LDX61_RS03440	COG0601	transmembrane transport
LDX61_RS03460	COG2816	NAD+ diphosphatase activity
LDX61_RS03465	COG0006	proline dipeptidase activity
LDX61_RS03490	COG0285	dihydrofolate synthase activity
LDX61_RS03520	COG2017	converts alpha-aldose to the beta-anomer
LDX61_RS03530	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LDX61_RS03545	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
LDX61_RS03575	COG0477	Major facilitator Superfamily
LDX61_RS03580	COG1217	gtp-binding protein TYPA
LDX61_RS03595	COG0287	Prephenate dehydrogenase
LDX61_RS03605	COG1929	Belongs to the glycerate kinase type-1 family
LDX61_RS03610	COG0577	efflux transmembrane transporter activity
LDX61_RS03615	COG4591	ABC-type transport system involved in lipoprotein release permease component
LDX61_RS03615	COG1136	(ABC) transporter
LDX61_RS03625	COG4166	transmembrane transport
LDX61_RS03630	COG0601	transmembrane transport
LDX61_RS03635	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LDX61_RS03650	COG0708	Exodeoxyribonuclease III
LDX61_RS03680	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
LDX61_RS03690	COG1335	isochorismatase
LDX61_RS03700	COG2826	transposase and inactivated derivatives, IS30 family
LDX61_RS03715	COG1131	(ABC) transporter
LDX61_RS03720	COG4585	Histidine kinase
LDX61_RS03725	COG2197	response regulator
LDX61_RS03730	COG0670	Belongs to the BI1 family
LDX61_RS03735	COG2357	RelA SpoT domain protein
LDX61_RS03755	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LDX61_RS03760	COG1058	Belongs to the CinA family
LDX61_RS03760	COG1546	Belongs to the CinA family
LDX61_RS03765	COG1396	sequence-specific DNA binding
LDX61_RS03790	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
LDX61_RS03800	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LDX61_RS03820	COG0142	geranyltranstransferase activity
LDX61_RS03830	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LDX61_RS03835	COG0187	DNA topoisomerase II activity
LDX61_RS03855	COG1201	RNA secondary structure unwinding
LDX61_RS03860	COG4975	Glucose uptake
LDX61_RS03865	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LDX61_RS03890	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LDX61_RS03895	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LDX61_RS03900	COG0561	phosphatase activity
LDX61_RS03905	COG1464	Belongs to the NlpA lipoprotein family
LDX61_RS03915	COG2011	ABC-type metal ion transport system permease component
LDX61_RS03920	COG1473	amidohydrolase
LDX61_RS03925	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LDX61_RS03925	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
LDX61_RS03935	COG1882	Formate acetyltransferase
LDX61_RS03940	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
LDX61_RS03995	COG1611	Belongs to the LOG family
LDX61_RS04005	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
LDX61_RS04010	COG1053	succinate dehydrogenase
LDX61_RS04015	COG0758	DNA mediated transformation
LDX61_RS04015	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LDX61_RS04030	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
LDX61_RS04035	COG2873	o-acetylhomoserine
LDX61_RS04040	COG1122	ATPase activity
LDX61_RS04050	COG0577	efflux transmembrane transporter activity
LDX61_RS04050	COG1136	(ABC) transporter
LDX61_RS04060	COG2197	response regulator
LDX61_RS04065	COG4585	Histidine kinase
LDX61_RS04075	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
LDX61_RS04080	COG0012	GTP binding
LDX61_RS04100	COG2233	PERMEase
LDX61_RS04105	COG0513	Belongs to the DEAD box helicase family
LDX61_RS04110	COG1028	Short-chain dehydrogenase reductase Sdr
LDX61_RS04135	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
LDX61_RS04160	COG1918	ferrous iron import across plasma membrane
LDX61_RS04160	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
LDX61_RS04170	COG1027	Aspartate ammonia-lyase
LDX61_RS04200	COG4552	Acetyltransferase involved in intracellular survival and related
LDX61_RS04215	COG1966	Carbon starvation protein
LDX61_RS04235	COG1247	-acetyltransferase
LDX61_RS04280	COG1760	l-serine dehydratase
LDX61_RS04290	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LDX61_RS04310	COG1674	ftsk spoiiie
LDX61_RS04315	COG1316	TRANSCRIPTIONal
LDX61_RS04320	COG1316	TRANSCRIPTIONal
LDX61_RS04350	COG2205	protein histidine kinase activity
LDX61_RS04355	COG0745	RESPONSE REGULATOR receiver
LDX61_RS04365	COG1329	Transcriptional regulator
LDX61_RS04375	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LDX61_RS04380	COG1121	(ABC) transporter
LDX61_RS04395	COG0539	negative regulation of cytoplasmic translation
LDX61_RS04400	COG0237	dephospho-CoA kinase activity
LDX61_RS04415	COG0469	pyruvate kinase activity
LDX61_RS04425	COG3655	Transcriptional regulator
LDX61_RS04475	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LDX61_RS04480	COG0857	belongs to the CobB CobQ family
LDX61_RS04480	COG0280	phosphate acetyltransferase
LDX61_RS04515	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LDX61_RS04520	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
LDX61_RS04605	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
LDX61_RS04640	COG1523	belongs to the glycosyl hydrolase 13 family
LDX61_RS04665	COG0577	efflux transmembrane transporter activity
LDX61_RS04665	COG1136	(ABC) transporter
LDX61_RS04690	COG1376	ErfK ybiS ycfS ynhG family protein
LDX61_RS04705	COG0396	ATPase activity
LDX61_RS04720	COG2151	metal-sulfur cluster biosynthetic enzyme
LDX61_RS04730	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LDX61_RS04740	COG0537	adenosine 5'-monophosphoramidase activity
LDX61_RS04770	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
LDX61_RS04795	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LDX61_RS04800	COG2860	membrane
LDX61_RS04820	COG0067	glutamate synthase
LDX61_RS04820	COG0069	glutamate synthase activity
LDX61_RS04820	COG0070	glutamate synthase
LDX61_RS04840	COG1119	ATPase activity
LDX61_RS04860	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
LDX61_RS04880	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LDX61_RS04885	COG0284	orotidine-5'-phosphate decarboxylase activity
LDX61_RS04890	COG0543	2 iron, 2 sulfur cluster binding
LDX61_RS04895	COG0167	dihydroorotate dehydrogenase activity
LDX61_RS04935	COG0583	DNA-binding transcription factor activity
LDX61_RS04945	COG0492	ferredoxin-NADP+ reductase activity
LDX61_RS04950	COG0450	alkyl hydroperoxide reductase
LDX61_RS04975	COG0488	(ABC) transporter
LDX61_RS05000	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LDX61_RS05025	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LDX61_RS05030	COG0561	phosphatase activity
LDX61_RS05035	COG0436	Aminotransferase
LDX61_RS05045	COG0436	Aminotransferase
LDX61_RS05050	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LDX61_RS05115	COG1131	(ABC) transporter
LDX61_RS05150	COG0488	(ABC) transporter
LDX61_RS05175	COG0438	transferase activity, transferring glycosyl groups
LDX61_RS05200	COG1862	Preprotein translocase
LDX61_RS05210	COG0045	succinate-CoA ligase (ADP-forming) activity
LDX61_RS05235	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LDX61_RS05270	COG4581	dead DEAH box helicase
LDX61_RS05295	COG1716	ATPase activity
LDX61_RS05315	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LDX61_RS05330	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LDX61_RS05345	COG0133	tryptophan synthase activity
LDX61_RS05400	COG4589	Belongs to the CDS family
LDX61_RS05430	COG1022	Amp-dependent synthetase and ligase
LDX61_RS05440	COG0516	GMP reductase activity
LDX61_RS05495	COG0802	atpase or kinase
LDX61_RS05525	COG0598	Magnesium transport protein CorA
LDX61_RS05530	COG0406	alpha-ribazole phosphatase activity
LDX61_RS05555	COG0588	phosphoglycerate mutase activity
LDX61_RS05560	COG0799	negative regulation of ribosome biogenesis
LDX61_RS05580	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
LDX61_RS05600	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LDX61_RS05615	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LDX61_RS05620	COG0569	domain protein
LDX61_RS05705	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LDX61_RS05710	COG0577	efflux transmembrane transporter activity
LDX61_RS05715	COG1136	(ABC) transporter
LDX61_RS05725	COG4721	ABC-type cobalt transport system, permease component
LDX61_RS05735	COG1136	(ABC) transporter
LDX61_RS05765	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LDX61_RS05775	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LDX61_RS05845	COG2151	metal-sulfur cluster biosynthetic enzyme
LDX61_RS05845	COG0489	protein tyrosine kinase activity
LDX61_RS05880	COG1122	ATPase activity
LDX61_RS05905	COG0656	L-ascorbic acid biosynthetic process
LDX61_RS05915	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
LDX61_RS05920	COG3304	Inner membrane component domain
LDX61_RS05945	COG1022	Amp-dependent synthetase and ligase
LDX61_RS05950	COG2814	Major facilitator Superfamily
LDX61_RS05965	COG2326	polyphosphate kinase activity
LDX61_RS05970	COG0765	amino acid transport
LDX61_RS05975	COG0765	amino acid transport
LDX61_RS05980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LDX61_RS05985	COG1126	abc transporter atp-binding protein
LDX61_RS06005	COG1196	nuclear chromosome segregation
LDX61_RS06010	COG0542	response to heat
LDX61_RS06015	COG0589	response to stress
LDX61_RS06030	COG1278	Cold shock
LDX61_RS06035	COG2205	protein histidine kinase activity
LDX61_RS06040	COG0745	RESPONSE REGULATOR receiver
LDX61_RS06060	COG1278	Cold shock
LDX61_RS06075	COG0714	Associated with various cellular activities
LDX61_RS06115	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LDX61_RS06150	COG1222	aaa ATPase
LDX61_RS06155	COG0586	Pfam SNARE associated Golgi protein
LDX61_RS06160	COG0560	Phosphoserine phosphatase
LDX61_RS06170	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LDX61_RS06175	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LDX61_RS06200	COG0284	orotidine-5'-phosphate decarboxylase activity
LDX61_RS06280	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LDX61_RS06340	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LDX61_RS06355	COG0151	Belongs to the GarS family
LDX61_RS06360	COG0477	Major facilitator Superfamily
LDX61_RS06375	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
LDX61_RS06380	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
LDX61_RS06390	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
LDX61_RS06395	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
LDX61_RS06405	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LDX61_RS06430	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
LDX61_RS06435	COG0358	DNA primase activity
LDX61_RS06445	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LDX61_RS06460	COG0371	Dehydrogenase
LDX61_RS06470	COG0514	ATP-dependent DNA helicase (RecQ)
LDX61_RS06490	COG4608	Belongs to the ABC transporter superfamily
LDX61_RS06495	COG0444	Belongs to the ABC transporter superfamily
LDX61_RS06500	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LDX61_RS06505	COG0601	transmembrane transport
LDX61_RS06510	COG4166	transmembrane transport
LDX61_RS06520	COG1653	transport
LDX61_RS06535	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LDX61_RS06540	COG2197	response regulator
LDX61_RS06550	COG0765	amino acid transport
LDX61_RS06555	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LDX61_RS06620	COG1971	Probably functions as a manganese efflux pump
LDX61_RS06645	COG3942	CHAP domain
LDX61_RS06645	COG1388	LysM domain
LDX61_RS06650	COG2177	Part of the ABC transporter FtsEX involved in
LDX61_RS06655	COG2884	Cell division ATP-binding protein ftsE
LDX61_RS06660	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
LDX61_RS06675	COG0372	Belongs to the citrate synthase family
LDX61_RS06690	COG3590	peptidase
LDX61_RS06710	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LDX61_RS06715	COG0561	phosphatase activity
LDX61_RS06740	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LDX61_RS06745	COG0009	L-threonylcarbamoyladenylate synthase
LDX61_RS06780	COG1940	carbohydrate kinase activity
LDX61_RS06785	COG1070	Carbohydrate kinase
LDX61_RS06795	COG2272	Belongs to the type-B carboxylesterase lipase family
LDX61_RS06805	COG3507	Belongs to the glycosyl hydrolase 43 family
LDX61_RS06815	COG1175	transmembrane transport
LDX61_RS06825	COG1609	Transcriptional regulator
LDX61_RS06835	COG3507	Belongs to the glycosyl hydrolase 43 family
LDX61_RS06845	COG2249	NAD(P)H dehydrogenase (quinone) activity
LDX61_RS06865	COG2873	o-acetylhomoserine
LDX61_RS06880	COG1946	Acyl-CoA thioesterase
LDX61_RS06895	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LDX61_RS06925	COG1215	transferase activity, transferring glycosyl groups
LDX61_RS06930	COG0628	permease
LDX61_RS06935	COG1216	Glycosyl transferase, family 2
LDX61_RS06940	COG0789	Transcriptional regulator
LDX61_RS06975	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
LDX61_RS06980	COG0531	amino acid
LDX61_RS06990	COG1454	alcohol dehydrogenase
LDX61_RS07010	COG1397	ADP-ribosylglycohydrolase
LDX61_RS07040	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LDX61_RS07050	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
LDX61_RS07055	COG4721	ABC-type cobalt transport system, permease component
LDX61_RS07060	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LDX61_RS07065	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
LDX61_RS07080	COG0589	response to stress
LDX61_RS07085	COG0791	NLP P60 protein
LDX61_RS07085	COG1388	LysM domain
LDX61_RS07085	COG3103	Sh3 type 3 domain protein
LDX61_RS07090	COG1388	LysM domain
LDX61_RS07090	COG3942	CHAP domain
LDX61_RS07095	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
LDX61_RS07110	COG5002	protein histidine kinase activity
LDX61_RS07125	COG4716	Myosin-crossreactive antigen
LDX61_RS07140	COG0300	oxidoreductase activity
LDX61_RS07150	COG0559	Belongs to the binding-protein-dependent transport system permease family
LDX61_RS07160	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
LDX61_RS07170	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
LDX61_RS07190	COG0626	cystathionine gamma-synthase activity
LDX61_RS07195	COG0390	transport system, permease component
LDX61_RS07200	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
LDX61_RS07220	COG2197	response regulator
LDX61_RS07255	COG1597	lipid kinase activity
LDX61_RS07255	COG1803	Methylglyoxal synthase
LDX61_RS07270	COG0328	RNA-DNA hybrid ribonuclease activity
LDX61_RS07295	COG0196	riboflavin kinase activity
LDX61_RS07430	COG0255	Belongs to the universal ribosomal protein uL29 family
LDX61_RS07490	COG1454	alcohol dehydrogenase
LDX61_RS07490	COG1012	belongs to the aldehyde dehydrogenase family
LDX61_RS07535	COG1739	Uncharacterized protein family UPF0029
LDX61_RS07550	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LDX61_RS07565	COG0531	amino acid
LDX61_RS07570	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LDX61_RS07610	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LDX61_RS07655	COG2252	PERMEase
LDX61_RS07665	COG0581	inorganic phosphate transmembrane transporter activity
LDX61_RS07680	COG0745	RESPONSE REGULATOR receiver
LDX61_RS07685	COG5002	protein histidine kinase activity
LDX61_RS07690	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
LDX61_RS07695	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LDX61_RS07700	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LDX61_RS07700	COG2755	lipolytic protein G-D-S-L family
LDX61_RS07705	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LDX61_RS07710	COG3579	cysteine-type endopeptidase activity
LDX61_RS07720	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
LDX61_RS07735	COG0826	peptidase U32
LDX61_RS07755	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LDX61_RS07780	COG1704	LemA family
LDX61_RS07795	COG0039	L-malate dehydrogenase activity
LDX61_RS07820	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LDX61_RS07825	COG4770	biotin carboxylase activity
LDX61_RS07875	COG0436	Aminotransferase
LDX61_RS07945	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LDX61_RS07965	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LDX61_RS08035	COG0667	Aldo Keto reductase
LDX61_RS08085	COG0488	(ABC) transporter
LDX61_RS08140	COG1837	Belongs to the UPF0109 family
LDX61_RS08155	COG0742	ribosomal rna small subunit methyltransferase
LDX61_RS08160	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LDX61_RS08170	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
LDX61_RS08170	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
LDX61_RS08185	COG0436	Aminotransferase
LDX61_RS08245	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LDX61_RS08355	COG0366	Alpha amylase catalytic