locus-tag	class	description
AH67_RS00010	COG0592	DNA-directed DNA polymerase activity
AH67_RS00025	COG0187	DNA topoisomerase II activity
AH67_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AH67_RS00045	COG1272	protein, Hemolysin III
AH67_RS00050	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AH67_RS00060	COG1970	mechanosensitive ion channel activity
AH67_RS00090	COG4974	Belongs to the 'phage' integrase family
AH67_RS00125	COG2226	methyltransferase
AH67_RS00130	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AH67_RS00215	COG0783	Belongs to the Dps family
AH67_RS00220	COG1253	flavin adenine dinucleotide binding
AH67_RS00230	COG0288	reversible hydration of carbon dioxide
AH67_RS00235	COG1609	Transcriptional regulator
AH67_RS00245	COG4214	carbohydrate transport
AH67_RS00260	COG1940	carbohydrate kinase activity
AH67_RS00260	COG1846	Transcriptional regulator
AH67_RS00275	COG3534	alpha-L-arabinofuranosidase
AH67_RS00295	COG0656	L-ascorbic acid biosynthetic process
AH67_RS00310	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AH67_RS00320	COG0180	Tryptophanyl-tRNA synthetase
AH67_RS00335	COG0058	SHG alpha-glucan phosphorylase activity
AH67_RS00365	COG3879	Bacterial protein of unknown function (DUF881)
AH67_RS00370	COG3764	Sortase (surface protein transpeptidase)
AH67_RS00385	COG0515	serine threonine protein kinase
AH67_RS00390	COG0768	penicillin binding
AH67_RS00425	COG0697	spore germination
AH67_RS00435	COG2226	methyltransferase
AH67_RS00450	COG0343	queuine tRNA-ribosyltransferase activity
AH67_RS00465	COG0493	'glutamate synthase
AH67_RS00530	COG4974	Belongs to the 'phage' integrase family
AH67_RS00550	COG2814	Major facilitator Superfamily
AH67_RS00560	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AH67_RS00585	COG0191	fructose-bisphosphate aldolase activity
AH67_RS00625	COG0477	Major facilitator Superfamily
AH67_RS00655	COG2182	Extracellular solute-binding protein
AH67_RS00660	COG1175	transmembrane transport
AH67_RS00665	COG0395	ABC-type sugar transport system, permease component
AH67_RS00675	COG1609	Transcriptional regulator
AH67_RS00700	COG3459	Glycosyltransferase 36 associated
AH67_RS00715	COG1113	amino acid transport
AH67_RS00725	COG0577	efflux transmembrane transporter activity
AH67_RS00725	COG1136	(ABC) transporter
AH67_RS00735	COG1113	amino acid transport
AH67_RS00740	COG1846	Transcriptional regulator
AH67_RS00760	COG0346	lactoylglutathione lyase activity
AH67_RS00770	COG0671	phosphoesterase, PA-phosphatase related
AH67_RS00805	COG1129	ABC transporter
AH67_RS00830	COG1309	transcriptional regulator
AH67_RS00850	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AH67_RS00860	COG1573	uracil-dna glycosylase
AH67_RS00865	COG1573	uracil-dna glycosylase
AH67_RS00870	COG0305	Participates in initiation and elongation during chromosome replication
AH67_RS00875	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AH67_RS00895	COG0584	glycerophosphoryl diester phosphodiesterase
AH67_RS00905	COG2261	transglycosylase associated protein
AH67_RS00910	COG2261	transglycosylase associated protein
AH67_RS00940	COG1653	transport
AH67_RS00945	COG1175	transmembrane transport
AH67_RS00950	COG0395	ABC-type sugar transport system, permease component
AH67_RS00960	COG0406	alpha-ribazole phosphatase activity
AH67_RS00960	COG0494	nUDIX hydrolase
AH67_RS01020	COG0527	aspartate kinase activity
AH67_RS01040	COG3507	Belongs to the glycosyl hydrolase 43 family
AH67_RS01045	COG3507	Belongs to the glycosyl hydrolase 43 family
AH67_RS01055	COG1609	Transcriptional regulator
AH67_RS01060	COG3940	Belongs to the glycosyl hydrolase 43 family
AH67_RS01065	COG1653	transport
AH67_RS01070	COG1175	transmembrane transport
AH67_RS01075	COG0395	ABC-type sugar transport system, permease component
AH67_RS01085	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AH67_RS01090	COG1260	myo-inositol-1-phosphate synthase
AH67_RS01100	COG1754	DNA topoisomerase type I activity
AH67_RS01100	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AH67_RS01115	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AH67_RS01120	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AH67_RS01210	COG0446	pyridine nucleotide-disulphide oxidoreductase
AH67_RS01215	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AH67_RS01290	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AH67_RS01305	COG0742	ribosomal rna small subunit methyltransferase
AH67_RS01320	COG1837	Belongs to the UPF0109 family
AH67_RS01380	COG0488	(ABC) transporter
AH67_RS01390	COG0440	acetolactate synthase activity
AH67_RS01430	COG0667	Aldo Keto reductase
AH67_RS01500	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AH67_RS01520	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AH67_RS01525	COG1530	ribonuclease E activity
AH67_RS01575	COG3550	peptidyl-serine autophosphorylation
AH67_RS01590	COG0436	Aminotransferase
AH67_RS01630	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
AH67_RS01630	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
AH67_RS01635	COG1268	BioY protein
AH67_RS01640	COG4770	biotin carboxylase activity
AH67_RS01645	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AH67_RS01675	COG0039	L-malate dehydrogenase activity
AH67_RS01690	COG1704	LemA family
AH67_RS01715	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AH67_RS01735	COG0826	peptidase U32
AH67_RS01740	COG1496	oxidoreductase activity
AH67_RS01750	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
AH67_RS01760	COG3579	cysteine-type endopeptidase activity
AH67_RS01765	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AH67_RS01770	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AH67_RS01770	COG2755	lipolytic protein G-D-S-L family
AH67_RS01775	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AH67_RS01780	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AH67_RS01785	COG5002	protein histidine kinase activity
AH67_RS01790	COG0745	RESPONSE REGULATOR receiver
AH67_RS01805	COG0581	inorganic phosphate transmembrane transporter activity
AH67_RS01835	COG2252	PERMEase
AH67_RS01880	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AH67_RS01920	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AH67_RS01925	COG0531	amino acid
AH67_RS01940	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AH67_RS01955	COG1739	Uncharacterized protein family UPF0029
AH67_RS02000	COG1012	belongs to the aldehyde dehydrogenase family
AH67_RS02000	COG1454	alcohol dehydrogenase
AH67_RS02060	COG0255	Belongs to the universal ribosomal protein uL29 family
AH67_RS02225	COG0196	riboflavin kinase activity
AH67_RS02245	COG0328	RNA-DNA hybrid ribonuclease activity
AH67_RS02260	COG1803	Methylglyoxal synthase
AH67_RS02260	COG1597	lipid kinase activity
AH67_RS02295	COG2197	response regulator
AH67_RS02315	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AH67_RS02320	COG0390	transport system, permease component
AH67_RS02325	COG0626	cystathionine gamma-synthase activity
AH67_RS02355	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AH67_RS02365	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AH67_RS02375	COG0559	Belongs to the binding-protein-dependent transport system permease family
AH67_RS02395	COG4716	Myosin-crossreactive antigen
AH67_RS02410	COG5002	protein histidine kinase activity
AH67_RS02425	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AH67_RS02430	COG1388	LysM domain
AH67_RS02430	COG3942	CHAP domain
AH67_RS02435	COG3103	Sh3 type 3 domain protein
AH67_RS02435	COG1388	LysM domain
AH67_RS02435	COG0791	NLP P60 protein
AH67_RS02440	COG0589	response to stress
AH67_RS02455	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AH67_RS02460	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AH67_RS02465	COG4721	ABC-type cobalt transport system, permease component
AH67_RS02470	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AH67_RS02480	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AH67_RS02540	COG1397	ADP-ribosylglycohydrolase
AH67_RS02560	COG1454	alcohol dehydrogenase
AH67_RS02570	COG0531	amino acid
AH67_RS02590	COG3842	ATPase activity
AH67_RS02635	COG0789	Transcriptional regulator
AH67_RS02645	COG1216	Glycosyl transferase, family 2
AH67_RS02650	COG0628	permease
AH67_RS02655	COG1215	transferase activity, transferring glycosyl groups
AH67_RS02685	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AH67_RS02700	COG1946	Acyl-CoA thioesterase
AH67_RS02710	COG2873	o-acetylhomoserine
AH67_RS02720	COG2249	NAD(P)H dehydrogenase (quinone) activity
AH67_RS02730	COG3507	Belongs to the glycosyl hydrolase 43 family
AH67_RS02735	COG1609	Transcriptional regulator
AH67_RS02745	COG1175	transmembrane transport
AH67_RS02755	COG3507	Belongs to the glycosyl hydrolase 43 family
AH67_RS02765	COG2272	Belongs to the type-B carboxylesterase lipase family
AH67_RS02775	COG1070	Carbohydrate kinase
AH67_RS02780	COG1940	carbohydrate kinase activity
AH67_RS02820	COG0009	L-threonylcarbamoyladenylate synthase
AH67_RS02825	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AH67_RS02855	COG0561	phosphatase activity
AH67_RS02860	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AH67_RS02880	COG3590	peptidase
AH67_RS02890	COG0024	Methionine aminopeptidase
AH67_RS02910	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AH67_RS02915	COG2884	Cell division ATP-binding protein ftsE
AH67_RS02920	COG2177	Part of the ABC transporter FtsEX involved in
AH67_RS02925	COG1388	LysM domain
AH67_RS02925	COG3942	CHAP domain
AH67_RS02950	COG1971	Probably functions as a manganese efflux pump
AH67_RS03015	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AH67_RS03020	COG0765	amino acid transport
AH67_RS03035	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AH67_RS03040	COG0564	pseudouridine synthase activity
AH67_RS03050	COG1653	transport
AH67_RS03060	COG4166	transmembrane transport
AH67_RS03065	COG0601	transmembrane transport
AH67_RS03070	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AH67_RS03075	COG0444	Belongs to the ABC transporter superfamily
AH67_RS03080	COG4608	Belongs to the ABC transporter superfamily
AH67_RS03100	COG0514	ATP-dependent DNA helicase (RecQ)
AH67_RS03110	COG0371	Dehydrogenase
AH67_RS03125	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AH67_RS03135	COG0358	DNA primase activity
AH67_RS03140	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AH67_RS03165	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AH67_RS03175	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AH67_RS03180	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AH67_RS03185	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AH67_RS03190	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
AH67_RS03205	COG0477	Major facilitator Superfamily
AH67_RS03225	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AH67_RS03275	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AH67_RS03355	COG0284	orotidine-5'-phosphate decarboxylase activity
AH67_RS03380	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AH67_RS03385	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AH67_RS03395	COG0560	Phosphoserine phosphatase
AH67_RS03400	COG0586	Pfam SNARE associated Golgi protein
AH67_RS03405	COG1222	aaa ATPase
AH67_RS03440	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AH67_RS03480	COG0714	Associated with various cellular activities
AH67_RS03495	COG1278	Cold shock
AH67_RS03515	COG0745	RESPONSE REGULATOR receiver
AH67_RS03520	COG2205	protein histidine kinase activity
AH67_RS03525	COG1278	Cold shock
AH67_RS03540	COG0589	response to stress
AH67_RS03550	COG1196	nuclear chromosome segregation
AH67_RS03570	COG1126	abc transporter atp-binding protein
AH67_RS03575	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AH67_RS03580	COG0765	amino acid transport
AH67_RS03585	COG0765	amino acid transport
AH67_RS03590	COG2326	polyphosphate kinase activity
AH67_RS03605	COG2814	Major facilitator Superfamily
AH67_RS03610	COG1022	Amp-dependent synthetase and ligase
AH67_RS03635	COG3304	Inner membrane component domain
AH67_RS03640	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AH67_RS03650	COG0656	L-ascorbic acid biosynthetic process
AH67_RS03675	COG1122	ATPase activity
AH67_RS03700	COG0489	protein tyrosine kinase activity
AH67_RS03700	COG2151	metal-sulfur cluster biosynthetic enzyme
AH67_RS03715	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AH67_RS03725	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AH67_RS03760	COG1136	(ABC) transporter
AH67_RS03770	COG4721	ABC-type cobalt transport system, permease component
AH67_RS03780	COG1136	(ABC) transporter
AH67_RS03785	COG0577	efflux transmembrane transporter activity
AH67_RS03790	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AH67_RS03875	COG0569	domain protein
AH67_RS03880	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AH67_RS03890	COG0497	DNA recombination
AH67_RS03915	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AH67_RS03935	COG0799	negative regulation of ribosome biogenesis
AH67_RS03940	COG0588	phosphoglycerate mutase activity
AH67_RS03965	COG0406	alpha-ribazole phosphatase activity
AH67_RS03970	COG0598	Magnesium transport protein CorA
AH67_RS04000	COG0802	atpase or kinase
AH67_RS04055	COG0516	GMP reductase activity
AH67_RS04065	COG1022	Amp-dependent synthetase and ligase
AH67_RS04095	COG4589	Belongs to the CDS family
AH67_RS04140	COG0133	tryptophan synthase activity
AH67_RS04155	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AH67_RS04170	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AH67_RS04190	COG1716	ATPase activity
AH67_RS04250	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AH67_RS04275	COG0045	succinate-CoA ligase (ADP-forming) activity
AH67_RS04285	COG1862	Preprotein translocase
AH67_RS04310	COG0438	transferase activity, transferring glycosyl groups
AH67_RS04315	COG1560	Kdo2-lipid A biosynthetic process
AH67_RS04335	COG0488	(ABC) transporter
AH67_RS04365	COG1131	(ABC) transporter
AH67_RS04385	COG2826	transposase and inactivated derivatives, IS30 family
AH67_RS04450	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AH67_RS04455	COG0436	Aminotransferase
AH67_RS04465	COG0436	Aminotransferase
AH67_RS04480	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AH67_RS04505	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AH67_RS04530	COG0488	(ABC) transporter
AH67_RS04555	COG0450	alkyl hydroperoxide reductase
AH67_RS04560	COG0492	ferredoxin-NADP+ reductase activity
AH67_RS04570	COG0583	DNA-binding transcription factor activity
AH67_RS04595	COG0167	dihydroorotate dehydrogenase activity
AH67_RS04605	COG0284	orotidine-5'-phosphate decarboxylase activity
AH67_RS04610	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AH67_RS04630	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AH67_RS04650	COG1119	ATPase activity
AH67_RS04670	COG0069	glutamate synthase activity
AH67_RS04670	COG0070	glutamate synthase
AH67_RS04670	COG0067	glutamate synthase
AH67_RS04690	COG2860	membrane
AH67_RS04695	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AH67_RS04720	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AH67_RS04750	COG0537	adenosine 5'-monophosphoramidase activity
AH67_RS04760	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AH67_RS04770	COG2151	metal-sulfur cluster biosynthetic enzyme
AH67_RS04785	COG0396	ATPase activity
AH67_RS04800	COG1376	ErfK ybiS ycfS ynhG family protein
AH67_RS04820	COG1136	(ABC) transporter
AH67_RS04820	COG0577	efflux transmembrane transporter activity
AH67_RS04835	COG1523	belongs to the glycosyl hydrolase 13 family
AH67_RS04840	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AH67_RS04890	COG1950	PFAM Membrane protein of
AH67_RS04925	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AH67_RS04935	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AH67_RS04975	COG0857	belongs to the CobB CobQ family
AH67_RS04975	COG0280	phosphate acetyltransferase
AH67_RS04980	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AH67_RS05130	COG3617	BRO family, N-terminal domain
AH67_RS05260	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AH67_RS05280	COG3655	Transcriptional regulator
AH67_RS05290	COG0469	pyruvate kinase activity
AH67_RS05305	COG0237	dephospho-CoA kinase activity
AH67_RS05310	COG0539	negative regulation of cytoplasmic translation
AH67_RS05325	COG1121	(ABC) transporter
AH67_RS05330	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AH67_RS05340	COG1329	Transcriptional regulator
AH67_RS05350	COG0745	RESPONSE REGULATOR receiver
AH67_RS05355	COG2205	protein histidine kinase activity
AH67_RS05360	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AH67_RS05385	COG1316	TRANSCRIPTIONal
AH67_RS05390	COG1316	TRANSCRIPTIONal
AH67_RS05395	COG1674	ftsk spoiiie
AH67_RS05415	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AH67_RS05425	COG1760	l-serine dehydratase
AH67_RS05470	COG1247	-acetyltransferase
AH67_RS05500	COG1027	Aspartate ammonia-lyase
AH67_RS05510	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
AH67_RS05510	COG1918	ferrous iron import across plasma membrane
AH67_RS05530	COG0363	glucosamine-6-phosphate deaminase activity
AH67_RS05535	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AH67_RS05555	COG2217	Heavy metal translocating P-type atpase
AH67_RS05560	COG1028	Short-chain dehydrogenase reductase Sdr
AH67_RS05570	COG2233	PERMEase
AH67_RS05590	COG0012	GTP binding
AH67_RS05595	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AH67_RS05605	COG4585	Histidine kinase
AH67_RS05610	COG2197	response regulator
AH67_RS05620	COG0577	efflux transmembrane transporter activity
AH67_RS05620	COG1136	(ABC) transporter
AH67_RS05630	COG1122	ATPase activity
AH67_RS05635	COG2873	o-acetylhomoserine
AH67_RS05640	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
AH67_RS05655	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AH67_RS05655	COG0758	DNA mediated transformation
AH67_RS05660	COG1053	succinate dehydrogenase
AH67_RS05665	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AH67_RS05675	COG1611	Belongs to the LOG family
AH67_RS05730	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AH67_RS05735	COG1882	Formate acetyltransferase
AH67_RS05745	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AH67_RS05745	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AH67_RS05750	COG1473	amidohydrolase
AH67_RS05755	COG2011	ABC-type metal ion transport system permease component
AH67_RS05765	COG1464	Belongs to the NlpA lipoprotein family
AH67_RS05775	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AH67_RS05780	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AH67_RS05805	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AH67_RS05810	COG4975	Glucose uptake
AH67_RS05835	COG0187	DNA topoisomerase II activity
AH67_RS05840	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AH67_RS05850	COG0142	geranyltranstransferase activity
AH67_RS05870	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AH67_RS05880	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AH67_RS05900	COG1396	sequence-specific DNA binding
AH67_RS05905	COG1058	Belongs to the CinA family
AH67_RS05905	COG1546	Belongs to the CinA family
AH67_RS05910	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AH67_RS05930	COG2357	RelA SpoT domain protein
AH67_RS05935	COG0670	Belongs to the BI1 family
AH67_RS05940	COG2197	response regulator
AH67_RS05945	COG4585	Histidine kinase
AH67_RS05950	COG1131	(ABC) transporter
AH67_RS05970	COG1335	isochorismatase
AH67_RS05975	COG0110	maltose O-acetyltransferase activity
AH67_RS05985	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AH67_RS06005	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AH67_RS06055	COG0708	Exodeoxyribonuclease III
AH67_RS06070	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AH67_RS06075	COG0601	transmembrane transport
AH67_RS06080	COG4166	transmembrane transport
AH67_RS06090	COG1136	(ABC) transporter
AH67_RS06090	COG4591	ABC-type transport system involved in lipoprotein release permease component
AH67_RS06095	COG0577	efflux transmembrane transporter activity
AH67_RS06100	COG1929	Belongs to the glycerate kinase type-1 family
AH67_RS06110	COG0287	Prephenate dehydrogenase
AH67_RS06125	COG1217	gtp-binding protein TYPA
AH67_RS06130	COG0477	Major facilitator Superfamily
AH67_RS06160	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AH67_RS06175	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AH67_RS06185	COG2017	converts alpha-aldose to the beta-anomer
AH67_RS06215	COG0285	dihydrofolate synthase activity
AH67_RS06230	COG0006	proline dipeptidase activity
AH67_RS06235	COG2816	NAD+ diphosphatase activity
AH67_RS06245	COG1940	carbohydrate kinase activity
AH67_RS06270	COG1609	Transcriptional regulator
AH67_RS06275	COG3250	beta-galactosidase activity
AH67_RS06315	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AH67_RS06325	COG0768	penicillin binding
AH67_RS06350	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AH67_RS06360	COG3858	chitin binding
AH67_RS06360	COG1388	LysM domain
AH67_RS06380	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AH67_RS06385	COG2813	Specifically methylates the guanine in position
AH67_RS06390	COG1643	Atp-dependent helicase
AH67_RS06400	COG0174	glutamine synthetase
AH67_RS06440	COG0587	DNA-directed DNA polymerase activity
AH67_RS06480	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AH67_RS06520	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AH67_RS06530	COG1957	nucleoside hydrolase
AH67_RS06580	COG3480	Lon protease (S16) C-terminal proteolytic domain
AH67_RS06615	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AH67_RS06640	COG1126	abc transporter atp-binding protein
AH67_RS06645	COG0765	amino acid transport
AH67_RS06650	COG0765	amino acid transport
AH67_RS06655	COG0436	Aminotransferase
AH67_RS06660	COG2011	ABC-type metal ion transport system permease component
AH67_RS06665	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AH67_RS06675	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AH67_RS06680	COG0531	amino acid
AH67_RS06690	COG2176	DNA-directed DNA polymerase activity
AH67_RS06745	COG4166	transmembrane transport
AH67_RS06750	COG2814	Major facilitator Superfamily
AH67_RS06755	COG1842	Phage shock protein A
AH67_RS06785	COG2365	Tyrosine phosphatase family
AH67_RS06800	COG1132	(ABC) transporter
AH67_RS06805	COG1132	(ABC) transporter
AH67_RS06895	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
AH67_RS06905	COG1924	4 iron, 4 sulfur cluster binding
AH67_RS06920	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AH67_RS06920	COG1328	CTP reductase activity
AH67_RS06925	COG1570	exodeoxyribonuclease VII activity
AH67_RS06930	COG1722	exodeoxyribonuclease VII activity
AH67_RS06950	COG0248	Ppx GppA phosphatase
AH67_RS06955	COG0436	Aminotransferase
AH67_RS06975	COG0531	amino acid
AH67_RS06980	COG3579	cysteine-type endopeptidase activity
AH67_RS07005	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AH67_RS07030	COG0210	DNA helicase
AH67_RS07040	COG2815	serine threonine protein kinase
AH67_RS07040	COG0515	serine threonine protein kinase
AH67_RS07050	COG0714	Associated with various cellular activities
AH67_RS07095	COG1194	a g-specific adenine glycosylase
AH67_RS07100	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AH67_RS07120	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AH67_RS07130	COG1349	DNA-binding transcription factor activity
AH67_RS07135	COG0463	Glycosyl transferase, family 2
AH67_RS07140	COG0167	dihydroorotate dehydrogenase activity
AH67_RS07145	COG1902	pentaerythritol trinitrate reductase activity
AH67_RS07150	COG4499	WXG100 protein secretion system (Wss), protein YukC
AH67_RS07150	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AH67_RS07155	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AH67_RS07165	COG2314	TM2 domain
AH67_RS07195	COG2267	carboxylic ester hydrolase activity
AH67_RS07205	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AH67_RS07225	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
AH67_RS07235	COG1088	dTDP-glucose 4,6-dehydratase activity
AH67_RS07255	COG1216	Glycosyl transferase, family 2
AH67_RS07285	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AH67_RS07295	COG2814	Major facilitator Superfamily
AH67_RS07335	COG1132	(ABC) transporter
AH67_RS07340	COG1022	Amp-dependent synthetase and ligase
AH67_RS07355	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AH67_RS07375	COG1216	Glycosyl transferase, family 2
AH67_RS07375	COG1442	glycosyl transferase family 8
AH67_RS07410	COG0463	Glycosyl transferase, family 2
AH67_RS07480	COG0489	protein tyrosine kinase activity
AH67_RS07485	COG0083	homoserine kinase activity
AH67_RS07490	COG0460	homoserine dehydrogenase
AH67_RS07505	COG0251	oxidation-reduction process
AH67_RS07535	COG0545	Peptidyl-prolyl cis-trans isomerase
AH67_RS07545	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AH67_RS07580	COG0356	it plays a direct role in the translocation of protons across the membrane
AH67_RS07605	COG0679	Auxin Efflux Carrier
AH67_RS07610	COG0028	Belongs to the TPP enzyme family
AH67_RS07630	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AH67_RS07640	COG0745	RESPONSE REGULATOR receiver
AH67_RS07675	COG1522	sequence-specific DNA binding
AH67_RS07735	COG2217	Heavy metal translocating P-type atpase
AH67_RS07745	COG0179	Fumarylacetoacetate (FAA) hydrolase
AH67_RS07750	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AH67_RS07765	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AH67_RS07785	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AH67_RS07855	COG0681	Belongs to the peptidase S26 family
AH67_RS07895	COG1368	sulfuric ester hydrolase activity
AH67_RS07900	COG1216	Glycosyl transferase, family 2
AH67_RS07905	COG0463	Glycosyl transferase, family 2
AH67_RS07940	COG1216	Glycosyl transferase, family 2
AH67_RS07960	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AH67_RS07980	COG0084	hydrolase, TatD family'
AH67_RS07995	COG1132	(ABC) transporter
AH67_RS08000	COG1132	(ABC) transporter
AH67_RS08040	COG1940	carbohydrate kinase activity
AH67_RS08055	COG0586	Pfam SNARE associated Golgi protein
AH67_RS08065	COG1501	Belongs to the glycosyl hydrolase 31 family
AH67_RS08075	COG1175	transmembrane transport
AH67_RS08085	COG1609	Transcriptional regulator
AH67_RS08100	COG1472	Belongs to the glycosyl hydrolase 3 family
AH67_RS08105	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AH67_RS08110	COG0789	Transcriptional regulator
AH67_RS08115	COG0484	heat shock protein binding
AH67_RS08130	COG1609	Transcriptional regulator
AH67_RS08145	COG1523	belongs to the glycosyl hydrolase 13 family
AH67_RS08150	COG3833	ABC-type maltose transport systems, permease component
AH67_RS08155	COG1175	transmembrane transport
AH67_RS08190	COG1609	Transcriptional regulator
AH67_RS08195	COG2182	Extracellular solute-binding protein
AH67_RS08200	COG0366	Alpha amylase catalytic
AH67_RS08205	COG0588	phosphoglycerate mutase activity
AH67_RS08215	COG0778	Nitroreductase
AH67_RS08275	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AH67_RS08280	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AH67_RS08295	COG0366	Alpha amylase catalytic
AH67_RS08305	COG0395	ABC-type sugar transport system, permease component
AH67_RS08310	COG1175	transmembrane transport
AH67_RS08315	COG1653	transport
AH67_RS08330	COG0037	tRNA processing
AH67_RS08330	COG0590	tRNA wobble adenosine to inosine editing
AH67_RS08335	COG0025	NhaP-type Na H and K H
AH67_RS08350	COG0596	Alpha beta hydrolase
AH67_RS08355	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AH67_RS08360	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AH67_RS08365	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AH67_RS08370	COG3443	Belongs to the bacterial solute-binding protein 9 family
AH67_RS08380	COG3842	ATPase activity
AH67_RS08385	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AH67_RS08405	COG3583	domain protein
AH67_RS08425	COG0617	tRNA 3'-terminal CCA addition
AH67_RS08465	COG0492	ferredoxin-NADP+ reductase activity
AH67_RS08480	COG1192	Involved in chromosome partitioning
AH67_RS08500	COG1847	R3H domain protein
AH67_RS08555	COG3231	kanamycin kinase activity
AH67_RS08580	COG0366	Alpha amylase catalytic
AH67_RS08595	COG1874	Beta-galactosidase
AH67_RS08655	COG0735	belongs to the Fur family
AH67_RS08715	COG1442	glycosyl transferase family 8
AH67_RS08715	COG1216	Glycosyl transferase, family 2
AH67_RS08720	COG0366	Alpha amylase catalytic
AH67_RS08725	COG0366	Alpha amylase catalytic
AH67_RS08730	COG0366	Alpha amylase catalytic