locus-tag	class	description
AH67_RS00010	COG0592	DNA-directed DNA polymerase activity
AH67_RS00025	COG0187	DNA topoisomerase II activity
AH67_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AH67_RS00045	COG1272	protein, Hemolysin III
AH67_RS00050	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AH67_RS00060	COG1970	mechanosensitive ion channel activity
AH67_RS00090	COG4974	Belongs to the 'phage' integrase family
AH67_RS00125	COG2226	methyltransferase
AH67_RS00130	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AH67_RS00160	COG3231	kanamycin kinase activity
AH67_RS00220	COG0366	Alpha amylase catalytic
AH67_RS00230	COG0783	Belongs to the Dps family
AH67_RS00235	COG1253	flavin adenine dinucleotide binding
AH67_RS00245	COG0288	reversible hydration of carbon dioxide
AH67_RS00250	COG1609	Transcriptional regulator
AH67_RS00260	COG4214	carbohydrate transport
AH67_RS00275	COG1940	carbohydrate kinase activity
AH67_RS00275	COG1846	Transcriptional regulator
AH67_RS00290	COG3534	alpha-L-arabinofuranosidase
AH67_RS00310	COG0656	L-ascorbic acid biosynthetic process
AH67_RS00325	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AH67_RS00335	COG0180	Tryptophanyl-tRNA synthetase
AH67_RS00350	COG0058	SHG alpha-glucan phosphorylase activity
AH67_RS00380	COG3879	Bacterial protein of unknown function (DUF881)
AH67_RS00385	COG3764	Sortase (surface protein transpeptidase)
AH67_RS00400	COG0515	serine threonine protein kinase
AH67_RS00405	COG0768	penicillin binding
AH67_RS00440	COG0697	spore germination
AH67_RS00450	COG2226	methyltransferase
AH67_RS00465	COG0343	queuine tRNA-ribosyltransferase activity
AH67_RS00480	COG0493	'glutamate synthase
AH67_RS00545	COG4974	Belongs to the 'phage' integrase family
AH67_RS00565	COG2814	Major facilitator Superfamily
AH67_RS00575	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AH67_RS00600	COG0191	fructose-bisphosphate aldolase activity
AH67_RS00640	COG0477	Major facilitator Superfamily
AH67_RS00670	COG2182	Extracellular solute-binding protein
AH67_RS00675	COG1175	transmembrane transport
AH67_RS00680	COG0395	ABC-type sugar transport system, permease component
AH67_RS00690	COG1609	Transcriptional regulator
AH67_RS00715	COG3459	Glycosyltransferase 36 associated
AH67_RS00730	COG1113	amino acid transport
AH67_RS00740	COG1136	(ABC) transporter
AH67_RS00740	COG0577	efflux transmembrane transporter activity
AH67_RS00750	COG1113	amino acid transport
AH67_RS00755	COG1846	Transcriptional regulator
AH67_RS00775	COG0346	lactoylglutathione lyase activity
AH67_RS00785	COG0671	phosphoesterase, PA-phosphatase related
AH67_RS00820	COG1129	ABC transporter
AH67_RS00840	COG1309	transcriptional regulator
AH67_RS00860	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AH67_RS00870	COG1573	uracil-dna glycosylase
AH67_RS00875	COG1573	uracil-dna glycosylase
AH67_RS00880	COG0305	Participates in initiation and elongation during chromosome replication
AH67_RS00885	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AH67_RS00905	COG0584	glycerophosphoryl diester phosphodiesterase
AH67_RS00915	COG2261	transglycosylase associated protein
AH67_RS00920	COG2261	transglycosylase associated protein
AH67_RS00935	COG1874	Beta-galactosidase
AH67_RS00950	COG1653	transport
AH67_RS00955	COG1175	transmembrane transport
AH67_RS00960	COG0395	ABC-type sugar transport system, permease component
AH67_RS00970	COG0406	alpha-ribazole phosphatase activity
AH67_RS00970	COG0494	nUDIX hydrolase
AH67_RS01030	COG0527	aspartate kinase activity
AH67_RS01050	COG3507	Belongs to the glycosyl hydrolase 43 family
AH67_RS01055	COG3507	Belongs to the glycosyl hydrolase 43 family
AH67_RS01065	COG1609	Transcriptional regulator
AH67_RS01070	COG3940	Belongs to the glycosyl hydrolase 43 family
AH67_RS01075	COG1653	transport
AH67_RS01080	COG1175	transmembrane transport
AH67_RS01085	COG0395	ABC-type sugar transport system, permease component
AH67_RS01095	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AH67_RS01100	COG1260	myo-inositol-1-phosphate synthase
AH67_RS01115	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AH67_RS01115	COG1754	DNA topoisomerase type I activity
AH67_RS01130	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AH67_RS01135	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AH67_RS01225	COG0446	pyridine nucleotide-disulphide oxidoreductase
AH67_RS01230	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AH67_RS01305	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AH67_RS01320	COG0742	ribosomal rna small subunit methyltransferase
AH67_RS01335	COG1837	Belongs to the UPF0109 family
AH67_RS01395	COG0488	(ABC) transporter
AH67_RS01405	COG0440	acetolactate synthase activity
AH67_RS01445	COG0667	Aldo Keto reductase
AH67_RS01515	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AH67_RS01535	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AH67_RS01540	COG1530	ribonuclease E activity
AH67_RS01590	COG3550	peptidyl-serine autophosphorylation
AH67_RS01605	COG0436	Aminotransferase
AH67_RS01645	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
AH67_RS01645	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
AH67_RS01650	COG1268	BioY protein
AH67_RS01655	COG4770	biotin carboxylase activity
AH67_RS01660	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AH67_RS01690	COG0039	L-malate dehydrogenase activity
AH67_RS01705	COG1704	LemA family
AH67_RS01730	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AH67_RS01750	COG0826	peptidase U32
AH67_RS01755	COG1496	oxidoreductase activity
AH67_RS01765	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
AH67_RS01775	COG3579	cysteine-type endopeptidase activity
AH67_RS01780	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AH67_RS01785	COG2755	lipolytic protein G-D-S-L family
AH67_RS01785	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AH67_RS01790	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AH67_RS01795	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AH67_RS01805	COG0745	RESPONSE REGULATOR receiver
AH67_RS01820	COG0581	inorganic phosphate transmembrane transporter activity
AH67_RS01850	COG2252	PERMEase
AH67_RS01895	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AH67_RS01935	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AH67_RS01940	COG0531	amino acid
AH67_RS01955	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AH67_RS01970	COG1739	Uncharacterized protein family UPF0029
AH67_RS02015	COG1012	belongs to the aldehyde dehydrogenase family
AH67_RS02015	COG1454	alcohol dehydrogenase
AH67_RS02080	COG0255	Belongs to the universal ribosomal protein uL29 family
AH67_RS02245	COG0196	riboflavin kinase activity
AH67_RS02265	COG0328	RNA-DNA hybrid ribonuclease activity
AH67_RS02280	COG1597	lipid kinase activity
AH67_RS02280	COG1803	Methylglyoxal synthase
AH67_RS02315	COG2197	response regulator
AH67_RS02335	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AH67_RS02340	COG0390	transport system, permease component
AH67_RS02345	COG0626	cystathionine gamma-synthase activity
AH67_RS02375	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AH67_RS02385	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AH67_RS02395	COG0559	Belongs to the binding-protein-dependent transport system permease family
AH67_RS02415	COG4716	Myosin-crossreactive antigen
AH67_RS02430	COG5002	protein histidine kinase activity
AH67_RS02445	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AH67_RS02450	COG3942	CHAP domain
AH67_RS02450	COG1388	LysM domain
AH67_RS02455	COG3103	Sh3 type 3 domain protein
AH67_RS02455	COG1388	LysM domain
AH67_RS02455	COG0791	NLP P60 protein
AH67_RS02460	COG0589	response to stress
AH67_RS02475	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AH67_RS02480	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AH67_RS02485	COG4721	ABC-type cobalt transport system, permease component
AH67_RS02490	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AH67_RS02500	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AH67_RS02560	COG1397	ADP-ribosylglycohydrolase
AH67_RS02580	COG1454	alcohol dehydrogenase
AH67_RS02590	COG0531	amino acid
AH67_RS02610	COG3842	ATPase activity
AH67_RS02655	COG0789	Transcriptional regulator
AH67_RS02665	COG1216	Glycosyl transferase, family 2
AH67_RS02670	COG0628	permease
AH67_RS02675	COG1215	transferase activity, transferring glycosyl groups
AH67_RS02705	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AH67_RS02720	COG1946	Acyl-CoA thioesterase
AH67_RS02730	COG2873	o-acetylhomoserine
AH67_RS02740	COG2249	NAD(P)H dehydrogenase (quinone) activity
AH67_RS02750	COG3507	Belongs to the glycosyl hydrolase 43 family
AH67_RS02755	COG1609	Transcriptional regulator
AH67_RS02765	COG1175	transmembrane transport
AH67_RS02775	COG3507	Belongs to the glycosyl hydrolase 43 family
AH67_RS02785	COG2272	Belongs to the type-B carboxylesterase lipase family
AH67_RS02795	COG1070	Carbohydrate kinase
AH67_RS02800	COG1940	carbohydrate kinase activity
AH67_RS02840	COG0009	L-threonylcarbamoyladenylate synthase
AH67_RS02845	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AH67_RS02875	COG0561	phosphatase activity
AH67_RS02880	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AH67_RS02900	COG3590	peptidase
AH67_RS02910	COG0024	Methionine aminopeptidase
AH67_RS02930	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AH67_RS02935	COG2884	Cell division ATP-binding protein ftsE
AH67_RS02940	COG2177	Part of the ABC transporter FtsEX involved in
AH67_RS02945	COG1388	LysM domain
AH67_RS02945	COG3942	CHAP domain
AH67_RS02970	COG1971	Probably functions as a manganese efflux pump
AH67_RS03035	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AH67_RS03040	COG0765	amino acid transport
AH67_RS03055	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AH67_RS03060	COG0564	pseudouridine synthase activity
AH67_RS03070	COG1653	transport
AH67_RS03080	COG4166	transmembrane transport
AH67_RS03085	COG0601	transmembrane transport
AH67_RS03090	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AH67_RS03095	COG0444	Belongs to the ABC transporter superfamily
AH67_RS03100	COG4608	Belongs to the ABC transporter superfamily
AH67_RS03120	COG0514	ATP-dependent DNA helicase (RecQ)
AH67_RS03130	COG0371	Dehydrogenase
AH67_RS03145	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AH67_RS03155	COG0358	DNA primase activity
AH67_RS03160	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AH67_RS03185	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AH67_RS03195	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AH67_RS03200	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AH67_RS03205	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AH67_RS03210	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
AH67_RS03225	COG0477	Major facilitator Superfamily
AH67_RS03245	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AH67_RS03295	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AH67_RS03375	COG0284	orotidine-5'-phosphate decarboxylase activity
AH67_RS03400	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AH67_RS03405	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AH67_RS03415	COG0560	Phosphoserine phosphatase
AH67_RS03420	COG0586	Pfam SNARE associated Golgi protein
AH67_RS03425	COG1222	aaa ATPase
AH67_RS03460	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AH67_RS03500	COG0714	Associated with various cellular activities
AH67_RS03515	COG1278	Cold shock
AH67_RS03535	COG0745	RESPONSE REGULATOR receiver
AH67_RS03540	COG2205	protein histidine kinase activity
AH67_RS03545	COG1278	Cold shock
AH67_RS03560	COG0589	response to stress
AH67_RS03570	COG1196	nuclear chromosome segregation
AH67_RS03590	COG1126	abc transporter atp-binding protein
AH67_RS03595	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AH67_RS03600	COG0765	amino acid transport
AH67_RS03605	COG0765	amino acid transport
AH67_RS03610	COG2326	polyphosphate kinase activity
AH67_RS03625	COG2814	Major facilitator Superfamily
AH67_RS03630	COG1022	Amp-dependent synthetase and ligase
AH67_RS03655	COG3304	Inner membrane component domain
AH67_RS03660	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AH67_RS03670	COG0656	L-ascorbic acid biosynthetic process
AH67_RS03695	COG1122	ATPase activity
AH67_RS03720	COG2151	metal-sulfur cluster biosynthetic enzyme
AH67_RS03720	COG0489	protein tyrosine kinase activity
AH67_RS03735	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AH67_RS03745	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AH67_RS03780	COG1136	(ABC) transporter
AH67_RS03790	COG4721	ABC-type cobalt transport system, permease component
AH67_RS03800	COG1136	(ABC) transporter
AH67_RS03805	COG0577	efflux transmembrane transporter activity
AH67_RS03810	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AH67_RS03895	COG0569	domain protein
AH67_RS03900	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AH67_RS03910	COG0497	DNA recombination
AH67_RS03935	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AH67_RS03955	COG0799	negative regulation of ribosome biogenesis
AH67_RS03960	COG0588	phosphoglycerate mutase activity
AH67_RS03985	COG0406	alpha-ribazole phosphatase activity
AH67_RS03990	COG0598	Magnesium transport protein CorA
AH67_RS04020	COG0802	atpase or kinase
AH67_RS04075	COG0516	GMP reductase activity
AH67_RS04085	COG1022	Amp-dependent synthetase and ligase
AH67_RS04115	COG4589	Belongs to the CDS family
AH67_RS04160	COG0133	tryptophan synthase activity
AH67_RS04175	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AH67_RS04190	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AH67_RS04210	COG1716	ATPase activity
AH67_RS04270	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AH67_RS04295	COG0045	succinate-CoA ligase (ADP-forming) activity
AH67_RS04305	COG1862	Preprotein translocase
AH67_RS04330	COG0438	transferase activity, transferring glycosyl groups
AH67_RS04335	COG1560	Kdo2-lipid A biosynthetic process
AH67_RS04355	COG0488	(ABC) transporter
AH67_RS04385	COG1131	(ABC) transporter
AH67_RS04405	COG2826	transposase and inactivated derivatives, IS30 family
AH67_RS04470	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AH67_RS04475	COG0436	Aminotransferase
AH67_RS04485	COG0436	Aminotransferase
AH67_RS04500	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AH67_RS04525	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AH67_RS04550	COG0488	(ABC) transporter
AH67_RS04575	COG0450	alkyl hydroperoxide reductase
AH67_RS04580	COG0492	ferredoxin-NADP+ reductase activity
AH67_RS04590	COG0583	DNA-binding transcription factor activity
AH67_RS04615	COG0167	dihydroorotate dehydrogenase activity
AH67_RS04625	COG0284	orotidine-5'-phosphate decarboxylase activity
AH67_RS04630	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AH67_RS04650	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AH67_RS04670	COG1119	ATPase activity
AH67_RS04690	COG0070	glutamate synthase
AH67_RS04690	COG0067	glutamate synthase
AH67_RS04690	COG0069	glutamate synthase activity
AH67_RS04710	COG2860	membrane
AH67_RS04715	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AH67_RS04740	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AH67_RS04770	COG0537	adenosine 5'-monophosphoramidase activity
AH67_RS04780	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AH67_RS04790	COG2151	metal-sulfur cluster biosynthetic enzyme
AH67_RS04805	COG0396	ATPase activity
AH67_RS04820	COG1376	ErfK ybiS ycfS ynhG family protein
AH67_RS04840	COG0577	efflux transmembrane transporter activity
AH67_RS04840	COG1136	(ABC) transporter
AH67_RS04855	COG1523	belongs to the glycosyl hydrolase 13 family
AH67_RS04860	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AH67_RS04910	COG1950	PFAM Membrane protein of
AH67_RS04945	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AH67_RS04955	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AH67_RS04995	COG0280	phosphate acetyltransferase
AH67_RS04995	COG0857	belongs to the CobB CobQ family
AH67_RS05000	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AH67_RS05150	COG3617	BRO family, N-terminal domain
AH67_RS05280	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AH67_RS05300	COG3655	Transcriptional regulator
AH67_RS05310	COG0469	pyruvate kinase activity
AH67_RS05325	COG0237	dephospho-CoA kinase activity
AH67_RS05330	COG0539	negative regulation of cytoplasmic translation
AH67_RS05345	COG1121	(ABC) transporter
AH67_RS05350	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AH67_RS05360	COG1329	Transcriptional regulator
AH67_RS05370	COG0745	RESPONSE REGULATOR receiver
AH67_RS05375	COG2205	protein histidine kinase activity
AH67_RS05380	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AH67_RS05405	COG1316	TRANSCRIPTIONal
AH67_RS05410	COG1316	TRANSCRIPTIONal
AH67_RS05415	COG1674	ftsk spoiiie
AH67_RS05435	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AH67_RS05445	COG1760	l-serine dehydratase
AH67_RS05490	COG1247	-acetyltransferase
AH67_RS05520	COG1027	Aspartate ammonia-lyase
AH67_RS05530	COG1918	ferrous iron import across plasma membrane
AH67_RS05530	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
AH67_RS05550	COG0363	glucosamine-6-phosphate deaminase activity
AH67_RS05555	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AH67_RS05575	COG2217	Heavy metal translocating P-type atpase
AH67_RS05580	COG1028	Short-chain dehydrogenase reductase Sdr
AH67_RS05590	COG2233	PERMEase
AH67_RS05610	COG0012	GTP binding
AH67_RS05615	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AH67_RS05625	COG4585	Histidine kinase
AH67_RS05630	COG2197	response regulator
AH67_RS05640	COG0577	efflux transmembrane transporter activity
AH67_RS05640	COG1136	(ABC) transporter
AH67_RS05650	COG1122	ATPase activity
AH67_RS05655	COG2873	o-acetylhomoserine
AH67_RS05660	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
AH67_RS05675	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AH67_RS05675	COG0758	DNA mediated transformation
AH67_RS05680	COG1053	succinate dehydrogenase
AH67_RS05685	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AH67_RS05695	COG1611	Belongs to the LOG family
AH67_RS05750	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
AH67_RS05755	COG1882	Formate acetyltransferase
AH67_RS05765	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AH67_RS05765	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AH67_RS05770	COG1473	amidohydrolase
AH67_RS05775	COG2011	ABC-type metal ion transport system permease component
AH67_RS05785	COG1464	Belongs to the NlpA lipoprotein family
AH67_RS05795	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AH67_RS05800	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AH67_RS05825	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AH67_RS05830	COG4975	Glucose uptake
AH67_RS05855	COG0187	DNA topoisomerase II activity
AH67_RS05860	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AH67_RS05870	COG0142	geranyltranstransferase activity
AH67_RS05890	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AH67_RS05900	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AH67_RS05925	COG1396	sequence-specific DNA binding
AH67_RS05930	COG1058	Belongs to the CinA family
AH67_RS05930	COG1546	Belongs to the CinA family
AH67_RS05935	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AH67_RS05955	COG2357	RelA SpoT domain protein
AH67_RS05960	COG0670	Belongs to the BI1 family
AH67_RS05965	COG2197	response regulator
AH67_RS05970	COG4585	Histidine kinase
AH67_RS05975	COG1131	(ABC) transporter
AH67_RS05995	COG1335	isochorismatase
AH67_RS06000	COG0110	maltose O-acetyltransferase activity
AH67_RS06010	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AH67_RS06030	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AH67_RS06080	COG0708	Exodeoxyribonuclease III
AH67_RS06095	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AH67_RS06100	COG0601	transmembrane transport
AH67_RS06105	COG4166	transmembrane transport
AH67_RS06115	COG1136	(ABC) transporter
AH67_RS06115	COG4591	ABC-type transport system involved in lipoprotein release permease component
AH67_RS06120	COG0577	efflux transmembrane transporter activity
AH67_RS06125	COG1929	Belongs to the glycerate kinase type-1 family
AH67_RS06135	COG0287	Prephenate dehydrogenase
AH67_RS06150	COG1217	gtp-binding protein TYPA
AH67_RS06155	COG0477	Major facilitator Superfamily
AH67_RS06185	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AH67_RS06200	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AH67_RS06210	COG2017	converts alpha-aldose to the beta-anomer
AH67_RS06240	COG0285	dihydrofolate synthase activity
AH67_RS06255	COG0006	proline dipeptidase activity
AH67_RS06260	COG2816	NAD+ diphosphatase activity
AH67_RS06270	COG1940	carbohydrate kinase activity
AH67_RS06300	COG1609	Transcriptional regulator
AH67_RS06305	COG3250	beta-galactosidase activity
AH67_RS06345	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AH67_RS06355	COG0768	penicillin binding
AH67_RS06380	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AH67_RS06390	COG3858	chitin binding
AH67_RS06390	COG1388	LysM domain
AH67_RS06410	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AH67_RS06415	COG2813	Specifically methylates the guanine in position
AH67_RS06420	COG1643	Atp-dependent helicase
AH67_RS06430	COG0174	glutamine synthetase
AH67_RS06470	COG0587	DNA-directed DNA polymerase activity
AH67_RS06510	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AH67_RS06550	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AH67_RS06560	COG1957	nucleoside hydrolase
AH67_RS06610	COG3480	Lon protease (S16) C-terminal proteolytic domain
AH67_RS06645	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AH67_RS06670	COG1126	abc transporter atp-binding protein
AH67_RS06675	COG0765	amino acid transport
AH67_RS06680	COG0765	amino acid transport
AH67_RS06685	COG0436	Aminotransferase
AH67_RS06690	COG2011	ABC-type metal ion transport system permease component
AH67_RS06695	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AH67_RS06705	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AH67_RS06710	COG0531	amino acid
AH67_RS06720	COG2176	DNA-directed DNA polymerase activity
AH67_RS06775	COG4166	transmembrane transport
AH67_RS06780	COG2814	Major facilitator Superfamily
AH67_RS06785	COG1842	Phage shock protein A
AH67_RS06810	COG2365	Tyrosine phosphatase family
AH67_RS06825	COG1132	(ABC) transporter
AH67_RS06830	COG1132	(ABC) transporter
AH67_RS06920	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
AH67_RS06930	COG1924	4 iron, 4 sulfur cluster binding
AH67_RS06945	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AH67_RS06945	COG1328	CTP reductase activity
AH67_RS06950	COG1570	exodeoxyribonuclease VII activity
AH67_RS06955	COG1722	exodeoxyribonuclease VII activity
AH67_RS06975	COG0248	Ppx GppA phosphatase
AH67_RS06980	COG0436	Aminotransferase
AH67_RS07000	COG0531	amino acid
AH67_RS07005	COG3579	cysteine-type endopeptidase activity
AH67_RS07030	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AH67_RS07055	COG0210	DNA helicase
AH67_RS07065	COG2815	serine threonine protein kinase
AH67_RS07065	COG0515	serine threonine protein kinase
AH67_RS07075	COG0714	Associated with various cellular activities
AH67_RS07120	COG1194	a g-specific adenine glycosylase
AH67_RS07125	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AH67_RS07145	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AH67_RS07155	COG1349	DNA-binding transcription factor activity
AH67_RS07160	COG0463	Glycosyl transferase, family 2
AH67_RS07165	COG0167	dihydroorotate dehydrogenase activity
AH67_RS07170	COG1902	pentaerythritol trinitrate reductase activity
AH67_RS07175	COG4499	WXG100 protein secretion system (Wss), protein YukC
AH67_RS07175	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AH67_RS07180	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AH67_RS07190	COG2314	TM2 domain
AH67_RS07220	COG2267	carboxylic ester hydrolase activity
AH67_RS07230	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AH67_RS07250	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
AH67_RS07260	COG1088	dTDP-glucose 4,6-dehydratase activity
AH67_RS07280	COG1216	Glycosyl transferase, family 2
AH67_RS07310	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AH67_RS07320	COG2814	Major facilitator Superfamily
AH67_RS07360	COG1132	(ABC) transporter
AH67_RS07365	COG1022	Amp-dependent synthetase and ligase
AH67_RS07380	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AH67_RS07400	COG1216	Glycosyl transferase, family 2
AH67_RS07400	COG1442	glycosyl transferase family 8
AH67_RS07435	COG0463	Glycosyl transferase, family 2
AH67_RS07455	COG1216	Glycosyl transferase, family 2
AH67_RS07455	COG1442	glycosyl transferase family 8
AH67_RS07460	COG0366	Alpha amylase catalytic
AH67_RS07465	COG0366	Alpha amylase catalytic
AH67_RS07470	COG0366	Alpha amylase catalytic
AH67_RS07480	COG0489	protein tyrosine kinase activity
AH67_RS07485	COG0083	homoserine kinase activity
AH67_RS07490	COG0460	homoserine dehydrogenase
AH67_RS07505	COG0251	oxidation-reduction process
AH67_RS07535	COG0545	Peptidyl-prolyl cis-trans isomerase
AH67_RS07545	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AH67_RS07580	COG0356	it plays a direct role in the translocation of protons across the membrane
AH67_RS07605	COG0679	Auxin Efflux Carrier
AH67_RS07610	COG0028	Belongs to the TPP enzyme family
AH67_RS07630	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AH67_RS07640	COG0745	RESPONSE REGULATOR receiver
AH67_RS07675	COG1522	sequence-specific DNA binding
AH67_RS07735	COG2217	Heavy metal translocating P-type atpase
AH67_RS07745	COG0179	Fumarylacetoacetate (FAA) hydrolase
AH67_RS07750	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AH67_RS07765	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AH67_RS07780	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AH67_RS07840	COG0681	Belongs to the peptidase S26 family
AH67_RS07880	COG1368	sulfuric ester hydrolase activity
AH67_RS07885	COG1216	Glycosyl transferase, family 2
AH67_RS07890	COG0463	Glycosyl transferase, family 2
AH67_RS07925	COG1216	Glycosyl transferase, family 2
AH67_RS07945	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AH67_RS07965	COG0084	hydrolase, TatD family'
AH67_RS07980	COG1132	(ABC) transporter
AH67_RS07985	COG1132	(ABC) transporter
AH67_RS08025	COG1940	carbohydrate kinase activity
AH67_RS08040	COG0586	Pfam SNARE associated Golgi protein
AH67_RS08050	COG1501	Belongs to the glycosyl hydrolase 31 family
AH67_RS08060	COG1175	transmembrane transport
AH67_RS08070	COG1609	Transcriptional regulator
AH67_RS08085	COG1472	Belongs to the glycosyl hydrolase 3 family
AH67_RS08090	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AH67_RS08095	COG0789	Transcriptional regulator
AH67_RS08100	COG0484	heat shock protein binding
AH67_RS08115	COG1609	Transcriptional regulator
AH67_RS08130	COG1523	belongs to the glycosyl hydrolase 13 family
AH67_RS08135	COG3833	ABC-type maltose transport systems, permease component
AH67_RS08140	COG1175	transmembrane transport
AH67_RS08175	COG1609	Transcriptional regulator
AH67_RS08180	COG2182	Extracellular solute-binding protein
AH67_RS08185	COG0366	Alpha amylase catalytic
AH67_RS08190	COG0588	phosphoglycerate mutase activity
AH67_RS08200	COG0778	Nitroreductase
AH67_RS08260	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AH67_RS08265	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AH67_RS08280	COG0366	Alpha amylase catalytic
AH67_RS08290	COG0395	ABC-type sugar transport system, permease component
AH67_RS08295	COG1175	transmembrane transport
AH67_RS08300	COG1653	transport
AH67_RS08315	COG0590	tRNA wobble adenosine to inosine editing
AH67_RS08315	COG0037	tRNA processing
AH67_RS08320	COG0025	NhaP-type Na H and K H
AH67_RS08335	COG0596	Alpha beta hydrolase
AH67_RS08340	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AH67_RS08345	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AH67_RS08350	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AH67_RS08355	COG3443	Belongs to the bacterial solute-binding protein 9 family
AH67_RS08365	COG3842	ATPase activity
AH67_RS08370	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AH67_RS08390	COG3583	domain protein
AH67_RS08410	COG0617	tRNA 3'-terminal CCA addition
AH67_RS08450	COG0492	ferredoxin-NADP+ reductase activity
AH67_RS08465	COG1192	Involved in chromosome partitioning
AH67_RS08485	COG1847	R3H domain protein