locus-tag	class	description
MF599_RS00010	COG0592	DNA-directed DNA polymerase activity
MF599_RS00025	COG0187	DNA topoisomerase II activity
MF599_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MF599_RS00090	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
MF599_RS00100	COG1970	mechanosensitive ion channel activity
MF599_RS00105	COG3534	alpha-L-arabinofuranosidase
MF599_RS00125	COG1609	Transcriptional regulator
MF599_RS00130	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MF599_RS00150	COG0783	Belongs to the Dps family
MF599_RS00160	COG1253	flavin adenine dinucleotide binding
MF599_RS00165	COG1609	Transcriptional regulator
MF599_RS00170	COG0288	reversible hydration of carbon dioxide
MF599_RS00190	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
MF599_RS00210	COG0180	Tryptophanyl-tRNA synthetase
MF599_RS00220	COG3279	Response regulator of the LytR AlgR family
MF599_RS00235	COG1088	dTDP-glucose 4,6-dehydratase activity
MF599_RS00250	COG0463	Glycosyl transferase, family 2
MF599_RS00320	COG1216	Glycosyl transferase, family 2
MF599_RS00325	COG3475	LICD family
MF599_RS00350	COG1216	Glycosyl transferase, family 2
MF599_RS00370	COG1088	dTDP-glucose 4,6-dehydratase activity
MF599_RS00380	COG1309	transcriptional regulator
MF599_RS00400	COG0758	DNA mediated transformation
MF599_RS00435	COG3942	CHAP domain
MF599_RS00435	COG1388	LysM domain
MF599_RS00445	COG2814	Major facilitator Superfamily
MF599_RS00480	COG0058	SHG alpha-glucan phosphorylase activity
MF599_RS00540	COG0515	serine threonine protein kinase
MF599_RS00545	COG0768	penicillin binding
MF599_RS00605	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MF599_RS00605	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MF599_RS00620	COG0513	Belongs to the DEAD box helicase family
MF599_RS00625	COG0494	nUDIX hydrolase
MF599_RS00660	COG0343	queuine tRNA-ribosyltransferase activity
MF599_RS00670	COG2217	Heavy metal translocating P-type atpase
MF599_RS00885	COG1475	DNA binding
MF599_RS00965	COG0191	fructose-bisphosphate aldolase activity
MF599_RS00970	COG0497	DNA recombination
MF599_RS01010	COG0477	Major facilitator Superfamily
MF599_RS01030	COG3250	beta-galactosidase activity
MF599_RS01035	COG1113	amino acid transport
MF599_RS01045	COG1136	(ABC) transporter
MF599_RS01045	COG0577	efflux transmembrane transporter activity
MF599_RS01125	COG0477	Major facilitator Superfamily
MF599_RS01135	COG2977	Belongs to the P-Pant transferase superfamily
MF599_RS01155	COG0667	Aldo Keto reductase
MF599_RS01165	COG1846	Transcriptional regulator
MF599_RS01175	COG1132	(ABC) transporter
MF599_RS01225	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MF599_RS01285	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MF599_RS01300	COG0167	dihydroorotate dehydrogenase activity
MF599_RS01305	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
MF599_RS01315	COG1309	transcriptional regulator
MF599_RS01375	COG1028	Short-chain dehydrogenase reductase Sdr
MF599_RS01390	COG0251	oxidation-reduction process
MF599_RS01395	COG0584	glycerophosphoryl diester phosphodiesterase
MF599_RS01410	COG1263	PTS System
MF599_RS01410	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MF599_RS01410	COG2190	(PTS) system
MF599_RS01415	COG1263	PTS System
MF599_RS01415	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MF599_RS01415	COG2190	(PTS) system
MF599_RS01420	COG0460	homoserine dehydrogenase
MF599_RS01425	COG0083	homoserine kinase activity
MF599_RS01445	COG1136	(ABC) transporter
MF599_RS01460	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MF599_RS01465	COG1530	ribonuclease E activity
MF599_RS01495	COG0436	Aminotransferase
MF599_RS01505	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
MF599_RS01530	COG0584	glycerophosphoryl diester phosphodiesterase
MF599_RS01535	COG0366	Alpha amylase catalytic
MF599_RS01595	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
MF599_RS01640	COG0179	Fumarylacetoacetate (FAA) hydrolase
MF599_RS01665	COG0436	Aminotransferase
MF599_RS01690	COG1022	Amp-dependent synthetase and ligase
MF599_RS01725	COG4106	trans-aconitate 2-methyltransferase activity
MF599_RS01770	COG0789	Transcriptional regulator
MF599_RS01775	COG2270	Major facilitator Superfamily
MF599_RS01815	COG1301	dicarboxylic acid transport
MF599_RS01820	COG0742	ribosomal rna small subunit methyltransferase
MF599_RS01830	COG0071	Belongs to the small heat shock protein (HSP20) family
MF599_RS01845	COG1837	Belongs to the UPF0109 family
MF599_RS01855	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MF599_RS01885	COG0519	Catalyzes the synthesis of GMP from XMP
MF599_RS01890	COG0488	(ABC) transporter
MF599_RS01930	COG0440	acetolactate synthase activity
MF599_RS02000	COG1285	pathogenesis
MF599_RS02005	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MF599_RS02010	COG1116	anion transmembrane transporter activity
MF599_RS02025	COG3775	system Galactitol-specific IIC component
MF599_RS02055	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
MF599_RS02060	COG1609	Transcriptional regulator
MF599_RS02095	COG1609	Transcriptional regulator
MF599_RS02110	COG0656	L-ascorbic acid biosynthetic process
MF599_RS02125	COG2814	Major facilitator Superfamily
MF599_RS02135	COG2801	Transposase and inactivated derivatives
MF599_RS02155	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MF599_RS02200	COG0095	Lipoate-protein ligase
MF599_RS02205	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MF599_RS02210	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MF599_RS02215	COG1902	pentaerythritol trinitrate reductase activity
MF599_RS02220	COG0167	dihydroorotate dehydrogenase activity
MF599_RS02225	COG1349	DNA-binding transcription factor activity
MF599_RS02235	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
MF599_RS02240	COG0477	Major facilitator Superfamily
MF599_RS02260	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
MF599_RS02320	COG0714	Associated with various cellular activities
MF599_RS02330	COG2815	serine threonine protein kinase
MF599_RS02330	COG0515	serine threonine protein kinase
MF599_RS02355	COG4172	Belongs to the ABC transporter superfamily
MF599_RS02380	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
MF599_RS02390	COG1404	Belongs to the peptidase S8 family
MF599_RS02415	COG0436	Aminotransferase
MF599_RS02435	COG2210	Belongs to the sulfur carrier protein TusA family
MF599_RS02455	COG1722	exodeoxyribonuclease VII activity
MF599_RS02460	COG1570	exodeoxyribonuclease VII activity
MF599_RS02465	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
MF599_RS02465	COG1328	CTP reductase activity
MF599_RS02470	COG0602	queuosine metabolic process
MF599_RS02505	COG1132	(ABC) transporter
MF599_RS02510	COG1132	(ABC) transporter
MF599_RS02525	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
MF599_RS02535	COG0613	PHP domain protein
MF599_RS02560	COG3480	Lon protease (S16) C-terminal proteolytic domain
MF599_RS02580	COG0351	phosphomethylpyrimidine kinase
MF599_RS02585	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MF599_RS02605	COG3250	beta-galactosidase activity
MF599_RS02620	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
MF599_RS02670	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
MF599_RS02675	COG2884	Cell division ATP-binding protein ftsE
MF599_RS02680	COG2177	Part of the ABC transporter FtsEX involved in
MF599_RS02685	COG1705	Flagellar rod assembly protein muramidase FlgJ
MF599_RS02685	COG3942	CHAP domain
MF599_RS02695	COG0564	pseudouridine synthase activity
MF599_RS02750	COG3878	Protein conserved in bacteria
MF599_RS02760	COG0587	DNA-directed DNA polymerase activity
MF599_RS02780	COG4716	Myosin-crossreactive antigen
MF599_RS02785	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
MF599_RS02795	COG0656	L-ascorbic acid biosynthetic process
MF599_RS02875	COG1643	Atp-dependent helicase
MF599_RS02880	COG2813	Specifically methylates the guanine in position
MF599_RS02890	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MF599_RS02920	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MF599_RS02945	COG0768	penicillin binding
MF599_RS02955	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
MF599_RS03045	COG0601	transmembrane transport
MF599_RS03050	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MF599_RS03060	COG0006	proline dipeptidase activity
MF599_RS03070	COG0285	dihydrofolate synthase activity
MF599_RS03075	COG1196	nuclear chromosome segregation
MF599_RS03080	COG1794	racemase activity, acting on amino acids and derivatives
MF599_RS03105	COG1595	DNA-templated transcription, initiation
MF599_RS03115	COG2017	converts alpha-aldose to the beta-anomer
MF599_RS03130	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
MF599_RS03145	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
MF599_RS03175	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
MF599_RS03185	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
MF599_RS03190	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
MF599_RS03200	COG1104	cysteine desulfurase activity
MF599_RS03205	COG1217	gtp-binding protein TYPA
MF599_RS03220	COG0287	Prephenate dehydrogenase
MF599_RS03260	COG0708	Exodeoxyribonuclease III
MF599_RS03320	COG1011	Hydrolase
MF599_RS03330	COG0560	Phosphoserine phosphatase
MF599_RS03335	COG1222	aaa ATPase
MF599_RS03340	COG4122	O-methyltransferase activity
MF599_RS03370	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
MF599_RS03410	COG0714	Associated with various cellular activities
MF599_RS03425	COG1278	Cold shock
MF599_RS03445	COG0745	RESPONSE REGULATOR receiver
MF599_RS03450	COG2205	protein histidine kinase activity
MF599_RS03455	COG1278	Cold shock
MF599_RS03490	COG1196	nuclear chromosome segregation
MF599_RS03515	COG1126	abc transporter atp-binding protein
MF599_RS03520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MF599_RS03525	COG0765	amino acid transport
MF599_RS03530	COG0765	amino acid transport
MF599_RS03535	COG2326	polyphosphate kinase activity
MF599_RS03550	COG2814	Major facilitator Superfamily
MF599_RS03575	COG1122	ATPase activity
MF599_RS03610	COG0582	viral genome integration into host DNA
MF599_RS03665	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MF599_RS03685	COG1136	(ABC) transporter
MF599_RS03710	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
MF599_RS03735	COG1682	transport, permease protein
MF599_RS03740	COG1134	teichoic acid transport
MF599_RS03760	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MF599_RS03765	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MF599_RS03800	COG1760	l-serine dehydratase
MF599_RS03810	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MF599_RS03840	COG1674	ftsk spoiiie
MF599_RS03845	COG1316	TRANSCRIPTIONal
MF599_RS03875	COG1040	competence protein
MF599_RS03885	COG2205	protein histidine kinase activity
MF599_RS03890	COG0745	RESPONSE REGULATOR receiver
MF599_RS03915	COG1121	(ABC) transporter
MF599_RS03930	COG0539	negative regulation of cytoplasmic translation
MF599_RS03950	COG0469	pyruvate kinase activity
MF599_RS03955	COG0494	nUDIX hydrolase
MF599_RS03975	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
MF599_RS03980	COG0494	nUDIX hydrolase
MF599_RS03995	COG2826	transposase and inactivated derivatives, IS30 family
MF599_RS04005	COG4974	Belongs to the 'phage' integrase family
MF599_RS04010	COG3340	Belongs to the peptidase S51 family
MF599_RS04020	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
MF599_RS04025	COG0280	phosphate acetyltransferase
MF599_RS04025	COG0857	belongs to the CobB CobQ family
MF599_RS04035	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
MF599_RS04060	COG2801	Transposase and inactivated derivatives
MF599_RS04095	COG0306	phosphate transporter
MF599_RS04105	COG2197	response regulator
MF599_RS04110	COG4585	Histidine kinase
MF599_RS04120	COG1131	(ABC) transporter
MF599_RS04140	COG2826	transposase and inactivated derivatives, IS30 family
MF599_RS04155	COG2826	transposase and inactivated derivatives, IS30 family
MF599_RS04195	COG1335	isochorismatase
MF599_RS04225	COG2755	lipolytic protein G-D-S-L family
MF599_RS04225	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
MF599_RS04255	COG2755	lipolytic protein G-D-S-L family
MF599_RS04255	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
MF599_RS04305	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
MF599_RS04335	COG0719	Fe-S assembly protein
MF599_RS04340	COG0396	ATPase activity
MF599_RS04355	COG2151	metal-sulfur cluster biosynthetic enzyme
MF599_RS04375	COG1385	rRNA (uridine-N3-)-methyltransferase activity
MF599_RS04380	COG0537	adenosine 5'-monophosphoramidase activity
MF599_RS04410	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
MF599_RS04435	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MF599_RS04455	COG2860	membrane
MF599_RS04480	COG0436	Aminotransferase
MF599_RS04490	COG0067	glutamate synthase
MF599_RS04490	COG0069	glutamate synthase activity
MF599_RS04490	COG0070	glutamate synthase
MF599_RS04505	COG0297	glycogen (starch) synthase activity
MF599_RS04510	COG1119	ATPase activity
MF599_RS04515	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MF599_RS04600	COG0513	Belongs to the DEAD box helicase family
MF599_RS04630	COG2962	Rard protein
MF599_RS04640	COG1073	alpha beta
MF599_RS04650	COG2062	phosphohistidine phosphatase, SixA
MF599_RS04660	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
MF599_RS04685	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
MF599_RS04690	COG0284	orotidine-5'-phosphate decarboxylase activity
MF599_RS04695	COG0543	2 iron, 2 sulfur cluster binding
MF599_RS04700	COG0167	dihydroorotate dehydrogenase activity
MF599_RS04715	COG1063	alcohol dehydrogenase
MF599_RS04735	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
MF599_RS04745	COG4221	oxidoreductase activity
MF599_RS04780	COG4106	trans-aconitate 2-methyltransferase activity
MF599_RS04790	COG3226	Transcriptional regulator
MF599_RS04800	COG0583	DNA-binding transcription factor activity
MF599_RS04915	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
MF599_RS04930	COG0133	tryptophan synthase activity
MF599_RS04945	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
MF599_RS04970	COG0045	succinate-CoA ligase (ADP-forming) activity
MF599_RS04980	COG1862	Preprotein translocase
MF599_RS05015	COG1301	dicarboxylic acid transport
MF599_RS05090	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
MF599_RS05095	COG3619	membrane
MF599_RS05100	COG1114	Component of the transport system for branched-chain amino acids
MF599_RS05125	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
MF599_RS05150	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MF599_RS05170	COG1136	(ABC) transporter
MF599_RS05170	COG0577	efflux transmembrane transporter activity
MF599_RS05180	COG0745	RESPONSE REGULATOR receiver
MF599_RS05185	COG2205	protein histidine kinase activity
MF599_RS05190	COG1876	peptidase activity
MF599_RS05195	COG0488	(ABC) transporter
MF599_RS05215	COG1940	carbohydrate kinase activity
MF599_RS05220	COG1940	carbohydrate kinase activity
MF599_RS05230	COG0395	ABC-type sugar transport system, permease component
MF599_RS05235	COG1175	transmembrane transport
MF599_RS05300	COG1022	Amp-dependent synthetase and ligase
MF599_RS05310	COG0516	GMP reductase activity
MF599_RS05325	COG1022	Amp-dependent synthetase and ligase
MF599_RS05345	COG0456	acetyltransferase
MF599_RS05355	COG0802	atpase or kinase
MF599_RS05380	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MF599_RS05385	COG0598	Magnesium transport protein CorA
MF599_RS05390	COG0406	alpha-ribazole phosphatase activity
MF599_RS05420	COG3189	MarR family transcriptional regulator
MF599_RS05470	COG2135	peptidase activity
MF599_RS05510	COG2249	NAD(P)H dehydrogenase (quinone) activity
MF599_RS05585	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
MF599_RS05615	COG1131	(ABC) transporter
MF599_RS05625	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MF599_RS05630	COG0497	DNA recombination
MF599_RS05640	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MF599_RS05645	COG0569	domain protein
MF599_RS05665	COG0647	UMP catabolic process
MF599_RS05785	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MF599_RS05790	COG1136	(ABC) transporter
MF599_RS05795	COG0390	transport system, permease component
MF599_RS05815	COG2233	PERMEase
MF599_RS05830	COG0583	DNA-binding transcription factor activity
MF599_RS05840	COG1442	glycosyl transferase family 8
MF599_RS05840	COG1216	Glycosyl transferase, family 2
MF599_RS05860	COG0242	peptide deformylase activity
MF599_RS05940	COG3177	Filamentation induced by cAMP protein fic
MF599_RS05945	COG0012	GTP binding
MF599_RS05950	COG0436	Aminotransferase
MF599_RS05960	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
MF599_RS05965	COG0022	dehydrogenase e1 component
MF599_RS05965	COG0508	dehydrogenase complex catalyzes the overall conversion of
MF599_RS05970	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
MF599_RS05985	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MF599_RS06000	COG2197	response regulator
MF599_RS06005	COG0671	phosphoesterase, PA-phosphatase related
MF599_RS06010	COG1136	(ABC) transporter
MF599_RS06010	COG0577	efflux transmembrane transporter activity
MF599_RS06015	COG1136	(ABC) transporter
MF599_RS06020	COG2873	o-acetylhomoserine
MF599_RS06035	COG1053	succinate dehydrogenase
MF599_RS06070	COG1611	Belongs to the LOG family
MF599_RS06075	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
MF599_RS06080	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
MF599_RS06140	COG1882	Formate acetyltransferase
MF599_RS06155	COG1473	amidohydrolase
MF599_RS06165	COG0561	phosphatase activity
MF599_RS06215	COG0489	protein tyrosine kinase activity
MF599_RS06250	COG0551	DNA topoisomerase type I activity
MF599_RS06250	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MF599_RS06275	COG3843	relaxase mobilization nuclease domain protein
MF599_RS06340	COG1196	nuclear chromosome segregation
MF599_RS06340	COG0741	lytic transglycosylase activity
MF599_RS06340	COG0739	heme binding
MF599_RS06405	COG4974	Belongs to the 'phage' integrase family
MF599_RS06435	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MF599_RS06460	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MF599_RS06465	COG1201	RNA secondary structure unwinding
MF599_RS06490	COG0187	DNA topoisomerase II activity
MF599_RS06495	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MF599_RS06505	COG0142	geranyltranstransferase activity
MF599_RS06525	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MF599_RS06535	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
MF599_RS06565	COG1396	sequence-specific DNA binding
MF599_RS06570	COG1546	Belongs to the CinA family
MF599_RS06570	COG1058	Belongs to the CinA family
MF599_RS06575	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MF599_RS06600	COG2357	RelA SpoT domain protein
MF599_RS06610	COG0670	Belongs to the BI1 family
MF599_RS06630	COG2197	response regulator
MF599_RS06710	COG2873	o-acetylhomoserine
MF599_RS06770	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MF599_RS06790	COG1368	sulfuric ester hydrolase activity
MF599_RS06795	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
MF599_RS06800	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
MF599_RS06825	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
MF599_RS06835	COG0257	Belongs to the bacterial ribosomal protein bL36 family
MF599_RS06845	COG0701	Predicted permease
MF599_RS06865	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
MF599_RS06870	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
MF599_RS06880	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
MF599_RS06890	COG1355	regulation of microtubule-based process
MF599_RS06915	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
MF599_RS06920	COG0531	amino acid
MF599_RS06940	COG0514	ATP-dependent DNA helicase (RecQ)
MF599_RS06995	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MF599_RS07060	COG1950	PFAM Membrane protein of
MF599_RS07065	COG1012	belongs to the aldehyde dehydrogenase family
MF599_RS07105	COG0446	pyridine nucleotide-disulphide oxidoreductase
MF599_RS07110	COG1929	Belongs to the glycerate kinase type-1 family
MF599_RS07115	COG0577	efflux transmembrane transporter activity
MF599_RS07115	COG1136	(ABC) transporter
MF599_RS07120	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MF599_RS07130	COG0667	Aldo Keto reductase
MF599_RS07135	COG2176	DNA-directed DNA polymerase activity
MF599_RS07145	COG0024	Methionine aminopeptidase
MF599_RS07155	COG3590	peptidase
MF599_RS07180	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MF599_RS07195	COG0366	Alpha amylase catalytic
MF599_RS07205	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MF599_RS07210	COG0009	L-threonylcarbamoyladenylate synthase
MF599_RS07245	COG4975	Glucose uptake
MF599_RS07250	COG0673	inositol 2-dehydrogenase activity
MF599_RS07255	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
MF599_RS07270	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MF599_RS07290	COG0513	Belongs to the DEAD box helicase family
MF599_RS07330	COG2873	o-acetylhomoserine
MF599_RS07340	COG2814	Major facilitator Superfamily
MF599_RS07350	COG1940	carbohydrate kinase activity
MF599_RS07355	COG0488	(ABC) transporter
MF599_RS07395	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
MF599_RS07420	COG1946	Acyl-CoA thioesterase
MF599_RS07430	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
MF599_RS07435	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
MF599_RS07445	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MF599_RS07450	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
MF599_RS07475	COG1215	transferase activity, transferring glycosyl groups
MF599_RS07485	COG1216	Glycosyl transferase, family 2
MF599_RS07490	COG1454	alcohol dehydrogenase
MF599_RS07515	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
MF599_RS07535	COG3250	beta-galactosidase activity
MF599_RS07545	COG1609	Transcriptional regulator
MF599_RS07555	COG0577	efflux transmembrane transporter activity
MF599_RS07565	COG1136	(ABC) transporter
MF599_RS07575	COG1687	branched-chain amino acid
MF599_RS07590	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
MF599_RS07605	COG0589	response to stress
MF599_RS07615	COG3942	CHAP domain
MF599_RS07615	COG1388	LysM domain
MF599_RS07630	COG5002	protein histidine kinase activity
MF599_RS07635	COG0704	Plays a role in the regulation of phosphate uptake
MF599_RS07655	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
MF599_RS07665	COG2814	Major facilitator Superfamily
MF599_RS07695	COG2197	response regulator
MF599_RS07700	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
MF599_RS07705	COG0363	glucosamine-6-phosphate deaminase activity
MF599_RS07745	COG0737	Belongs to the 5'-nucleotidase family
MF599_RS07745	COG1525	nuclease
MF599_RS07745	COG4085	toxin activity
MF599_RS07750	COG1597	lipid kinase activity
MF599_RS07750	COG1803	Methylglyoxal synthase
MF599_RS07760	COG2190	(PTS) system
MF599_RS07760	COG1263	PTS System
MF599_RS07760	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MF599_RS07785	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MF599_RS07795	COG0328	RNA-DNA hybrid ribonuclease activity
MF599_RS07820	COG0196	riboflavin kinase activity
MF599_RS07865	COG2308	Evidence 4 Homologs of previously reported genes of
MF599_RS07915	COG0201	protein transport
MF599_RS07975	COG0255	Belongs to the universal ribosomal protein uL29 family
MF599_RS08035	COG3527	Alpha-acetolactate decarboxylase
MF599_RS08040	COG1012	belongs to the aldehyde dehydrogenase family
MF599_RS08040	COG1454	alcohol dehydrogenase
MF599_RS08075	COG1739	Uncharacterized protein family UPF0029
MF599_RS08090	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MF599_RS08100	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
MF599_RS08105	COG0812	UDP-N-acetylmuramate dehydrogenase activity
MF599_RS08135	COG0714	Associated with various cellular activities
MF599_RS08160	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
MF599_RS08200	COG0657	acetylesterase activity
MF599_RS08200	COG2755	lipolytic protein G-D-S-L family
MF599_RS08205	COG4409	exo-alpha-(2->6)-sialidase activity
MF599_RS08215	COG2252	PERMEase
MF599_RS08230	COG0581	inorganic phosphate transmembrane transporter activity
MF599_RS08245	COG0745	RESPONSE REGULATOR receiver
MF599_RS08250	COG5002	protein histidine kinase activity
MF599_RS08255	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
MF599_RS08260	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
MF599_RS08275	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
MF599_RS08295	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
MF599_RS08310	COG0826	peptidase U32
MF599_RS08320	COG0656	L-ascorbic acid biosynthetic process
MF599_RS08335	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MF599_RS08340	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MF599_RS08350	COG0626	cystathionine gamma-synthase activity
MF599_RS08360	COG1704	LemA family
MF599_RS08365	COG1609	Transcriptional regulator
MF599_RS08410	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
MF599_RS08415	COG4770	biotin carboxylase activity
MF599_RS08420	COG1268	BioY protein
MF599_RS08425	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
MF599_RS08425	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
MF599_RS08445	COG0355	proton-transporting ATP synthase activity, rotational mechanism
MF599_RS08480	COG0356	it plays a direct role in the translocation of protons across the membrane
MF599_RS08520	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
MF599_RS08535	COG0745	RESPONSE REGULATOR receiver
MF599_RS08545	COG0747	negative chemotaxis
MF599_RS08560	COG0287	Prephenate dehydrogenase
MF599_RS08560	COG1605	Chorismate mutase
MF599_RS08565	COG1522	sequence-specific DNA binding
MF599_RS08570	COG0436	Aminotransferase
MF599_RS08640	COG1322	Protein conserved in bacteria
MF599_RS08645	COG1937	Protein conserved in bacteria
MF599_RS08670	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
MF599_RS08675	COG0305	Participates in initiation and elongation during chromosome replication
MF599_RS08685	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
MF599_RS08705	COG1309	transcriptional regulator
MF599_RS08710	COG1216	Glycosyl transferase, family 2
MF599_RS08740	COG1132	(ABC) transporter
MF599_RS08780	COG0561	phosphatase activity
MF599_RS08795	COG0561	phosphatase activity
MF599_RS08800	COG2723	6-phospho-beta-galactosidase activity
MF599_RS08815	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MF599_RS08825	COG1609	Transcriptional regulator
MF599_RS08840	COG0577	efflux transmembrane transporter activity
MF599_RS08855	COG3470	protein probably involved in high-affinity Fe2 transport
MF599_RS08860	COG0672	)-iron permease
MF599_RS08895	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MF599_RS08900	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MF599_RS08900	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
MF599_RS08910	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
MF599_RS08920	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MF599_RS08920	COG1754	DNA topoisomerase type I activity
MF599_RS08935	COG1404	Belongs to the peptidase S8 family
MF599_RS08950	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MF599_RS09010	COG1597	lipid kinase activity
MF599_RS09050	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
MF599_RS09055	COG0406	alpha-ribazole phosphatase activity
MF599_RS09055	COG0494	nUDIX hydrolase
MF599_RS09070	COG1216	Glycosyl transferase, family 2
MF599_RS09105	COG1136	(ABC) transporter
MF599_RS09130	COG0084	hydrolase, TatD family'
MF599_RS09145	COG1609	Transcriptional regulator
MF599_RS09180	COG0586	Pfam SNARE associated Golgi protein
MF599_RS09205	COG0789	Transcriptional regulator
MF599_RS09230	COG1609	Transcriptional regulator
MF599_RS09245	COG0588	phosphoglycerate mutase activity
MF599_RS09255	COG0778	Nitroreductase
MF599_RS09280	COG3231	kanamycin kinase activity
MF599_RS09300	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
MF599_RS09305	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
MF599_RS09310	COG0037	tRNA processing
MF599_RS09310	COG0590	tRNA wobble adenosine to inosine editing
MF599_RS09320	COG0025	NhaP-type Na H and K H
MF599_RS09335	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MF599_RS09340	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MF599_RS09375	COG3842	ATPase activity
MF599_RS09400	COG3583	domain protein
MF599_RS09420	COG0617	tRNA 3'-terminal CCA addition
MF599_RS09440	COG0492	ferredoxin-NADP+ reductase activity
MF599_RS09450	COG1192	Involved in chromosome partitioning
MF599_RS09460	COG1847	R3H domain protein