locus-tag	class	description
D805_RS00010	COG0592	DNA-directed DNA polymerase activity
D805_RS00025	COG0187	DNA topoisomerase II activity
D805_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D805_RS00050	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D805_RS00055	COG1970	mechanosensitive ion channel activity
D805_RS00090	COG1253	flavin adenine dinucleotide binding
D805_RS00095	COG0288	reversible hydration of carbon dioxide
D805_RS00110	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
D805_RS00125	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
D805_RS00155	COG1716	ATPase activity
D805_RS00170	COG0768	penicillin binding
D805_RS00175	COG0515	serine threonine protein kinase
D805_RS00210	COG0457	Tetratricopeptide repeat
D805_RS00210	COG0705	Rhomboid family
D805_RS00220	COG0058	SHG alpha-glucan phosphorylase activity
D805_RS00230	COG0180	Tryptophanyl-tRNA synthetase
D805_RS00240	COG0343	queuine tRNA-ribosyltransferase activity
D805_RS00260	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D805_RS00270	COG4172	Belongs to the ABC transporter superfamily
D805_RS00275	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D805_RS00290	COG2226	methyltransferase
D805_RS00310	COG0601	transmembrane transport
D805_RS00315	COG0747	negative chemotaxis
D805_RS00320	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D805_RS00330	COG1216	Glycosyl transferase, family 2
D805_RS00345	COG0477	Major facilitator Superfamily
D805_RS00380	COG0242	peptide deformylase activity
D805_RS00390	COG4115	mRNA cleavage
D805_RS00410	COG0257	Belongs to the bacterial ribosomal protein bL36 family
D805_RS00420	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
D805_RS00425	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D805_RS00430	COG0227	Belongs to the bacterial ribosomal protein bL28 family
D805_RS00440	COG0300	oxidoreductase activity
D805_RS00445	COG0191	fructose-bisphosphate aldolase activity
D805_RS00530	COG2211	Major facilitator Superfamily
D805_RS00535	COG0477	Major facilitator Superfamily
D805_RS00550	COG1609	Transcriptional regulator
D805_RS00570	COG1113	amino acid transport
D805_RS00580	COG0475	glutathione-regulated potassium exporter activity
D805_RS00585	COG1609	Transcriptional regulator
D805_RS00590	COG0366	Alpha amylase catalytic
D805_RS00645	COG1113	amino acid transport
D805_RS00675	COG0667	Aldo Keto reductase
D805_RS00705	COG1132	(ABC) transporter
D805_RS00710	COG3177	Filamentation induced by cAMP protein fic
D805_RS00740	COG0442	prolyl-tRNA aminoacylation
D805_RS00795	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D805_RS00800	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D805_RS00810	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D805_RS00820	COG0363	glucosamine-6-phosphate deaminase activity
D805_RS00860	COG0765	amino acid transport
D805_RS00865	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D805_RS00870	COG1126	abc transporter atp-binding protein
D805_RS00880	COG1216	Glycosyl transferase, family 2
D805_RS00880	COG1442	glycosyl transferase family 8
D805_RS00885	COG1309	transcriptional regulator
D805_RS00905	COG0004	ammonium transporteR
D805_RS00920	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
D805_RS00930	COG0305	Participates in initiation and elongation during chromosome replication
D805_RS00935	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
D805_RS00940	COG3442	glutamine amidotransferase
D805_RS00955	COG0584	glycerophosphoryl diester phosphodiesterase
D805_RS00975	COG0494	nUDIX hydrolase
D805_RS00975	COG0406	alpha-ribazole phosphatase activity
D805_RS00980	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
D805_RS01095	COG1136	(ABC) transporter
D805_RS01095	COG0577	efflux transmembrane transporter activity
D805_RS01110	COG1754	DNA topoisomerase type I activity
D805_RS01110	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D805_RS01130	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
D805_RS01130	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D805_RS01135	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D805_RS01230	COG5646	InterPro IPR014922
D805_RS01235	COG0167	dihydroorotate dehydrogenase activity
D805_RS01245	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D805_RS01255	COG0561	phosphatase activity
D805_RS01310	COG2270	Major facilitator Superfamily
D805_RS01325	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
D805_RS01330	COG0742	ribosomal rna small subunit methyltransferase
D805_RS01355	COG1837	Belongs to the UPF0109 family
D805_RS01380	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
D805_RS01380	COG0512	Glutamine amidotransferase of anthranilate synthase
D805_RS01385	COG0488	(ABC) transporter
D805_RS01390	COG0440	acetolactate synthase activity
D805_RS01510	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
D805_RS01515	COG1609	Transcriptional regulator
D805_RS01520	COG4988	ABC transporter
D805_RS01535	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D805_RS01560	COG2814	Major facilitator Superfamily
D805_RS01570	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D805_RS01580	COG0438	transferase activity, transferring glycosyl groups
D805_RS01630	COG1045	serine acetyltransferase
D805_RS01635	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D805_RS01655	COG1088	dTDP-glucose 4,6-dehydratase activity
D805_RS01725	COG1442	glycosyl transferase family 8
D805_RS01740	COG0438	transferase activity, transferring glycosyl groups
D805_RS01740	COG1216	Glycosyl transferase, family 2
D805_RS01755	COG1216	Glycosyl transferase, family 2
D805_RS01760	COG1368	sulfuric ester hydrolase activity
D805_RS01775	COG0489	protein tyrosine kinase activity
D805_RS01865	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D805_RS01915	COG0095	Lipoate-protein ligase
D805_RS01925	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D805_RS01930	COG1902	pentaerythritol trinitrate reductase activity
D805_RS01945	COG0714	Associated with various cellular activities
D805_RS01955	COG2815	serine threonine protein kinase
D805_RS01955	COG0515	serine threonine protein kinase
D805_RS01965	COG0167	dihydroorotate dehydrogenase activity
D805_RS01970	COG1216	Glycosyl transferase, family 2
D805_RS01975	COG1349	DNA-binding transcription factor activity
D805_RS01985	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
D805_RS02030	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
D805_RS02075	COG0210	DNA helicase
D805_RS02100	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
D805_RS02115	COG2361	Protein of unknown function DUF86
D805_RS02120	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D805_RS02130	COG1454	alcohol dehydrogenase
D805_RS02165	COG1722	exodeoxyribonuclease VII activity
D805_RS02170	COG1570	exodeoxyribonuclease VII activity
D805_RS02175	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
D805_RS02175	COG1328	CTP reductase activity
D805_RS02200	COG1309	transcriptional regulator
D805_RS02220	COG1132	(ABC) transporter
D805_RS02240	COG0667	Aldo Keto reductase
D805_RS02245	COG1929	Belongs to the glycerate kinase type-1 family
D805_RS02265	COG0626	cystathionine gamma-synthase activity
D805_RS02280	COG2873	o-acetylhomoserine
D805_RS02285	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D805_RS02310	COG1464	Belongs to the NlpA lipoprotein family
D805_RS02315	COG2011	ABC-type metal ion transport system permease component
D805_RS02320	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D805_RS02335	COG0436	Aminotransferase
D805_RS02370	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
D805_RS02380	COG0613	PHP domain protein
D805_RS02405	COG3480	Lon protease (S16) C-terminal proteolytic domain
D805_RS02450	COG1609	Transcriptional regulator
D805_RS02485	COG0351	phosphomethylpyrimidine kinase
D805_RS02485	COG0352	thiamine-phosphate diphosphorylase activity
D805_RS02515	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D805_RS02545	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
D805_RS02570	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D805_RS02605	COG0587	DNA-directed DNA polymerase activity
D805_RS02640	COG0174	glutamine synthetase
D805_RS02655	COG1643	Atp-dependent helicase
D805_RS02660	COG2813	Specifically methylates the guanine in position
D805_RS02665	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D805_RS02695	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D805_RS02720	COG0768	penicillin binding
D805_RS02730	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
D805_RS02765	COG1199	ATP-dependent helicase activity
D805_RS02765	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D805_RS02860	COG1518	maintenance of DNA repeat elements
D805_RS02865	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
D805_RS02895	COG1846	Transcriptional regulator
D805_RS02895	COG1940	carbohydrate kinase activity
D805_RS02905	COG0601	transmembrane transport
D805_RS02910	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D805_RS02920	COG0006	proline dipeptidase activity
D805_RS02930	COG0285	dihydrofolate synthase activity
D805_RS02935	COG1196	nuclear chromosome segregation
D805_RS02955	COG1595	DNA-templated transcription, initiation
D805_RS02965	COG2017	converts alpha-aldose to the beta-anomer
D805_RS02975	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
D805_RS02995	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
D805_RS03020	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
D805_RS03025	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
D805_RS03030	COG1217	gtp-binding protein TYPA
D805_RS03045	COG0287	Prephenate dehydrogenase
D805_RS03060	COG4166	transmembrane transport
D805_RS03065	COG0601	transmembrane transport
D805_RS03070	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D805_RS03080	COG0708	Exodeoxyribonuclease III
D805_RS03135	COG0604	alcohol dehydrogenase
D805_RS03150	COG4716	Myosin-crossreactive antigen
D805_RS03155	COG0583	DNA-binding transcription factor activity
D805_RS03165	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
D805_RS03180	COG0670	Belongs to the BI1 family
D805_RS03190	COG0351	phosphomethylpyrimidine kinase
D805_RS03195	COG2357	RelA SpoT domain protein
D805_RS03220	COG1058	Belongs to the CinA family
D805_RS03220	COG1546	Belongs to the CinA family
D805_RS03225	COG1396	sequence-specific DNA binding
D805_RS03245	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
D805_RS03255	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
D805_RS03275	COG0142	geranyltranstransferase activity
D805_RS03285	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D805_RS03290	COG0187	DNA topoisomerase II activity
D805_RS03295	COG0438	transferase activity, transferring glycosyl groups
D805_RS03310	COG3655	Transcriptional regulator
D805_RS03345	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D805_RS03350	COG1136	(ABC) transporter
D805_RS03390	COG0561	phosphatase activity
D805_RS03395	COG1464	Belongs to the NlpA lipoprotein family
D805_RS03405	COG2011	ABC-type metal ion transport system permease component
D805_RS03410	COG1473	amidohydrolase
D805_RS03415	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
D805_RS03415	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D805_RS03425	COG1882	Formate acetyltransferase
D805_RS03430	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
D805_RS03470	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
D805_RS03475	COG1611	Belongs to the LOG family
D805_RS03485	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
D805_RS03490	COG1053	succinate dehydrogenase
D805_RS03520	COG2873	o-acetylhomoserine
D805_RS03535	COG1122	ATPase activity
D805_RS03540	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
D805_RS03545	COG0577	efflux transmembrane transporter activity
D805_RS03545	COG1136	(ABC) transporter
D805_RS03555	COG2197	response regulator
D805_RS03565	COG4585	Histidine kinase
D805_RS03575	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
D805_RS03580	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
D805_RS03595	COG0012	GTP binding
D805_RS03600	COG1376	ErfK ybiS ycfS ynhG family protein
D805_RS03610	COG2233	PERMEase
D805_RS03615	COG0390	transport system, permease component
D805_RS03620	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
D805_RS03630	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D805_RS03790	COG1760	l-serine dehydratase
D805_RS03800	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D805_RS03820	COG1674	ftsk spoiiie
D805_RS03825	COG1316	TRANSCRIPTIONal
D805_RS03830	COG1316	TRANSCRIPTIONal
D805_RS03875	COG2205	protein histidine kinase activity
D805_RS03880	COG0745	RESPONSE REGULATOR receiver
D805_RS03900	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D805_RS03905	COG1121	(ABC) transporter
D805_RS03920	COG0539	negative regulation of cytoplasmic translation
D805_RS03940	COG0469	pyruvate kinase activity
D805_RS03950	COG3842	ATPase activity
D805_RS03990	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
D805_RS03995	COG1051	belongs to the nudix hydrolase family
D805_RS04025	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
D805_RS04030	COG0280	phosphate acetyltransferase
D805_RS04030	COG0857	belongs to the CobB CobQ family
D805_RS04065	COG0210	DNA helicase
D805_RS04075	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
D805_RS04085	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D805_RS04095	COG1953	Uracil, thiamine, allantoin
D805_RS04200	COG0488	(ABC) transporter
D805_RS04205	COG0488	(ABC) transporter
D805_RS04210	COG2814	Major facilitator Superfamily
D805_RS04230	COG2094	Belongs to the DNA glycosylase MPG family
D805_RS04235	COG1131	(ABC) transporter
D805_RS04255	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D805_RS04310	COG2755	lipolytic protein G-D-S-L family
D805_RS04310	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
D805_RS04315	COG0588	phosphoglycerate mutase activity
D805_RS04355	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
D805_RS04360	COG1523	belongs to the glycosyl hydrolase 13 family
D805_RS04380	COG0719	Fe-S assembly protein
D805_RS04385	COG0396	ATPase activity
D805_RS04395	COG0822	iron-sulfur transferase activity
D805_RS04400	COG2151	metal-sulfur cluster biosynthetic enzyme
D805_RS04420	COG0537	adenosine 5'-monophosphoramidase activity
D805_RS04450	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
D805_RS04475	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D805_RS04480	COG2860	membrane
D805_RS04525	COG0110	maltose O-acetyltransferase activity
D805_RS04530	COG0067	glutamate synthase
D805_RS04530	COG0069	glutamate synthase activity
D805_RS04530	COG0070	glutamate synthase
D805_RS04560	COG0516	GMP reductase activity
D805_RS04600	COG0575	Belongs to the CDS family
D805_RS04625	COG0133	tryptophan synthase activity
D805_RS04640	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
D805_RS04695	COG0546	phosphoglycolate phosphatase activity
D805_RS04705	COG4581	dead DEAH box helicase
D805_RS04740	COG1187	pseudouridine synthase activity
D805_RS04770	COG0045	succinate-CoA ligase (ADP-forming) activity
D805_RS04805	COG0438	transferase activity, transferring glycosyl groups
D805_RS04885	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
D805_RS04890	COG0436	Aminotransferase
D805_RS04900	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D805_RS04940	COG0488	(ABC) transporter
D805_RS04965	COG0583	DNA-binding transcription factor activity
D805_RS04975	COG0167	dihydroorotate dehydrogenase activity
D805_RS04985	COG0284	orotidine-5'-phosphate decarboxylase activity
D805_RS04990	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D805_RS05030	COG1119	ATPase activity
D805_RS05045	COG1687	branched-chain amino acid
D805_RS05055	COG1022	Amp-dependent synthetase and ligase
D805_RS05075	COG1454	alcohol dehydrogenase
D805_RS05095	COG2326	polyphosphate kinase activity
D805_RS05105	COG0765	amino acid transport
D805_RS05110	COG0765	amino acid transport
D805_RS05115	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D805_RS05120	COG1126	abc transporter atp-binding protein
D805_RS05135	COG1196	nuclear chromosome segregation
D805_RS05145	COG0589	response to stress
D805_RS05155	COG1278	Cold shock
D805_RS05160	COG2205	protein histidine kinase activity
D805_RS05165	COG0745	RESPONSE REGULATOR receiver
D805_RS05185	COG1278	Cold shock
D805_RS05200	COG0714	Associated with various cellular activities
D805_RS05240	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
D805_RS05255	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
D805_RS05270	COG4122	O-methyltransferase activity
D805_RS05275	COG1222	aaa ATPase
D805_RS05280	COG0586	Pfam SNARE associated Golgi protein
D805_RS05285	COG0560	Phosphoserine phosphatase
D805_RS05295	COG1011	Hydrolase
D805_RS05310	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
D805_RS05315	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
D805_RS05340	COG0284	orotidine-5'-phosphate decarboxylase activity
D805_RS05365	COG1304	FMN binding
D805_RS05395	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
D805_RS05405	COG1177	transmembrane transport
D805_RS05410	COG1176	ABC-type spermidine putrescine transport system, permease component I
D805_RS05415	COG3842	ATPase activity
D805_RS05420	COG1522	sequence-specific DNA binding
D805_RS05425	COG1012	belongs to the aldehyde dehydrogenase family
D805_RS05445	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D805_RS05485	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D805_RS05505	COG1368	sulfuric ester hydrolase activity
D805_RS05515	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
D805_RS05530	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
D805_RS05535	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
D805_RS05540	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
D805_RS05555	COG0577	efflux transmembrane transporter activity
D805_RS05555	COG1136	(ABC) transporter
D805_RS05565	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
D805_RS05595	COG4770	biotin carboxylase activity
D805_RS05600	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
D805_RS05605	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
D805_RS05620	COG0358	DNA primase activity
D805_RS05630	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D805_RS05635	COG0531	amino acid
D805_RS05650	COG1528	Iron-storage protein
D805_RS05655	COG0514	ATP-dependent DNA helicase (RecQ)
D805_RS05660	COG0626	cystathionine gamma-synthase activity
D805_RS05675	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D805_RS05690	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D805_RS05695	COG0601	transmembrane transport
D805_RS05710	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
D805_RS05730	COG0564	pseudouridine synthase activity
D805_RS05735	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D805_RS05760	COG1136	(ABC) transporter
D805_RS05805	COG3942	CHAP domain
D805_RS05805	COG1388	LysM domain
D805_RS05810	COG2177	Part of the ABC transporter FtsEX involved in
D805_RS05815	COG2884	Cell division ATP-binding protein ftsE
D805_RS05820	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
D805_RS05840	COG3759	membrane
D805_RS05850	COG0024	Methionine aminopeptidase
D805_RS05860	COG3590	peptidase
D805_RS05885	COG4209	transmembrane transport
D805_RS05890	COG0395	ABC-type sugar transport system, permease component
D805_RS05905	COG1621	beta-fructofuranosidase activity
D805_RS05915	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D805_RS05930	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D805_RS05940	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D805_RS05945	COG0009	L-threonylcarbamoyladenylate synthase
D805_RS05980	COG0385	Bile acid
D805_RS05995	COG2249	NAD(P)H dehydrogenase (quinone) activity
D805_RS06000	COG0436	Aminotransferase
D805_RS06015	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
D805_RS06020	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
D805_RS06040	COG2011	ABC-type metal ion transport system permease component
D805_RS06045	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D805_RS06055	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
D805_RS06060	COG0436	Aminotransferase
D805_RS06090	COG1373	ATPase (AAA superfamily
D805_RS06100	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D805_RS06120	COG1946	Acyl-CoA thioesterase
D805_RS06130	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
D805_RS06150	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D805_RS06155	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
D805_RS06170	COG1215	transferase activity, transferring glycosyl groups
D805_RS06180	COG1216	Glycosyl transferase, family 2
D805_RS06185	COG1454	alcohol dehydrogenase
D805_RS06240	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
D805_RS06255	COG0589	response to stress
D805_RS06260	COG0791	NLP P60 protein
D805_RS06265	COG1705	Flagellar rod assembly protein muramidase FlgJ
D805_RS06265	COG3942	CHAP domain
D805_RS06270	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
D805_RS06300	COG1575	Belongs to the MenA family. Type 1 subfamily
D805_RS06310	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
D805_RS06360	COG2197	response regulator
D805_RS06380	COG1803	Methylglyoxal synthase
D805_RS06380	COG1597	lipid kinase activity
D805_RS06405	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D805_RS06425	COG0154	amidase activity
D805_RS06430	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D805_RS06435	COG2188	Transcriptional regulator
D805_RS06450	COG0789	Transcriptional regulator
D805_RS06455	COG1063	alcohol dehydrogenase
D805_RS06460	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D805_RS06475	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
D805_RS06485	COG0252	asparaginase activity
D805_RS06485	COG5275	peptidyl-tyrosine sulfation
D805_RS06490	COG4656	Part of a membrane complex involved in electron transport
D805_RS06500	COG0601	transmembrane transport
D805_RS06505	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D805_RS06515	COG0747	negative chemotaxis
D805_RS06525	COG0328	RNA-DNA hybrid ribonuclease activity
D805_RS06550	COG0196	riboflavin kinase activity
D805_RS06685	COG0255	Belongs to the universal ribosomal protein uL29 family
D805_RS06745	COG1454	alcohol dehydrogenase
D805_RS06745	COG1012	belongs to the aldehyde dehydrogenase family
D805_RS06775	COG1739	Uncharacterized protein family UPF0029
D805_RS06785	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D805_RS06800	COG0531	amino acid
D805_RS06805	COG0812	UDP-N-acetylmuramate dehydrogenase activity
D805_RS06830	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D805_RS06840	COG0714	Associated with various cellular activities
D805_RS06855	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D805_RS06860	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
D805_RS06910	COG2252	PERMEase
D805_RS06925	COG0581	inorganic phosphate transmembrane transporter activity
D805_RS06940	COG0745	RESPONSE REGULATOR receiver
D805_RS06945	COG5002	protein histidine kinase activity
D805_RS06950	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
D805_RS06955	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
D805_RS06960	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
D805_RS06965	COG3579	cysteine-type endopeptidase activity
D805_RS06975	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
D805_RS06990	COG0826	peptidase U32
D805_RS07010	COG1704	LemA family
D805_RS07055	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D805_RS07060	COG4770	biotin carboxylase activity
D805_RS07065	COG1268	BioY protein
D805_RS07100	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D805_RS07110	COG0436	Aminotransferase
D805_RS07135	COG1530	ribonuclease E activity
D805_RS07140	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D805_RS07155	COG0083	homoserine kinase activity
D805_RS07160	COG0460	homoserine dehydrogenase
D805_RS07175	COG0833	amino acid
D805_RS07180	COG0251	oxidation-reduction process
D805_RS07235	COG0355	proton-transporting ATP synthase activity, rotational mechanism
D805_RS07270	COG0356	it plays a direct role in the translocation of protons across the membrane
D805_RS07300	COG1113	amino acid transport
D805_RS07305	COG0252	asparaginase activity
D805_RS07315	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
D805_RS07330	COG0745	RESPONSE REGULATOR receiver
D805_RS07355	COG0287	Prephenate dehydrogenase
D805_RS07355	COG1605	Chorismate mutase
D805_RS07420	COG1322	Protein conserved in bacteria
D805_RS07425	COG1937	Protein conserved in bacteria
D805_RS07450	COG0346	lactoylglutathione lyase activity
D805_RS07455	COG0179	Fumarylacetoacetate (FAA) hydrolase
D805_RS07470	COG0395	ABC-type sugar transport system, permease component
D805_RS07510	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D805_RS07540	COG1177	transmembrane transport
D805_RS07545	COG1176	ABC-type spermidine putrescine transport system, permease component I
D805_RS07550	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
D805_RS07555	COG3842	ATPase activity
D805_RS07565	COG0705	Rhomboid family
D805_RS07565	COG0457	Tetratricopeptide repeat
D805_RS07610	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
D805_RS07630	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D805_RS07645	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D805_RS07665	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
D805_RS07705	COG1714	RDD family
D805_RS07725	COG1136	(ABC) transporter
D805_RS07725	COG0577	efflux transmembrane transporter activity
D805_RS07745	COG0084	hydrolase, TatD family'
D805_RS07750	COG3579	cysteine-type endopeptidase activity
D805_RS07755	COG1733	regulation of RNA biosynthetic process
D805_RS07760	COG2910	NAD(P)H-binding
D805_RS07815	COG0586	Pfam SNARE associated Golgi protein
D805_RS07830	COG1285	pathogenesis
D805_RS07840	COG0789	Transcriptional regulator
D805_RS07845	COG0484	heat shock protein binding
D805_RS07865	COG1609	Transcriptional regulator
D805_RS07875	COG0546	phosphoglycolate phosphatase activity
D805_RS07890	COG1175	transmembrane transport
D805_RS07895	COG3833	ABC-type maltose transport systems, permease component
D805_RS07900	COG1523	belongs to the glycosyl hydrolase 13 family
D805_RS07935	COG0588	phosphoglycerate mutase activity
D805_RS07945	COG0778	Nitroreductase
D805_RS07955	COG0477	Major facilitator Superfamily
D805_RS07960	COG0656	L-ascorbic acid biosynthetic process
D805_RS08025	COG0456	acetyltransferase
D805_RS08035	COG0802	atpase or kinase
D805_RS08050	COG1555	photosystem II stabilization
D805_RS08050	COG1596	polysaccharide export
D805_RS08065	COG0598	Magnesium transport protein CorA
D805_RS08090	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D805_RS08110	COG1355	regulation of microtubule-based process
D805_RS08115	COG0406	alpha-ribazole phosphatase activity
D805_RS08145	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
D805_RS08165	COG2188	Transcriptional regulator
D805_RS08170	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D805_RS08185	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D805_RS08190	COG0569	domain protein
D805_RS08295	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D805_RS08300	COG4475	Protein of unknown function (DUF436)
D805_RS08310	COG1122	ATPase activity
D805_RS08320	COG4721	ABC-type cobalt transport system, permease component
D805_RS08325	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D805_RS08335	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D805_RS08370	COG1122	ATPase activity
D805_RS08430	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
D805_RS08435	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D805_RS08440	COG0366	Alpha amylase catalytic
D805_RS08450	COG1609	Transcriptional regulator
D805_RS08455	COG0395	ABC-type sugar transport system, permease component
D805_RS08460	COG1175	transmembrane transport
D805_RS08475	COG2197	response regulator
D805_RS08490	COG0577	efflux transmembrane transporter activity
D805_RS08490	COG1136	(ABC) transporter
D805_RS08505	COG2197	response regulator
D805_RS08510	COG0730	response to heat
D805_RS08520	COG0037	tRNA processing
D805_RS08520	COG0590	tRNA wobble adenosine to inosine editing
D805_RS08525	COG0025	NhaP-type Na H and K H
D805_RS08530	COG0596	Alpha beta hydrolase
D805_RS08530	COG2226	methyltransferase
D805_RS08530	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D805_RS08540	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
D805_RS08545	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D805_RS08555	COG3842	ATPase activity
D805_RS08575	COG3583	domain protein
D805_RS08595	COG0617	tRNA 3'-terminal CCA addition
D805_RS08615	COG0492	ferredoxin-NADP+ reductase activity
D805_RS08620	COG1475	DNA binding
D805_RS08625	COG1192	Involved in chromosome partitioning
D805_RS08635	COG1847	R3H domain protein
D805_RS08695	COG0726	polysaccharide deacetylase
D805_RS08740	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
D805_RS08760	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
D805_RS08770	COG2137	regulation of response to DNA damage stimulus
D805_RS08805	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine