locus-tag	class	description
A6A11_RS00005	COG3070	regulator of competence-specific genes
A6A11_RS00010	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A6A11_RS00030	COG0551	DNA topoisomerase type I activity
A6A11_RS00050	COG0583	DNA-binding transcription factor activity
A6A11_RS00065	COG3005	denitrification pathway
A6A11_RS00080	COG1629	transport
A6A11_RS00080	COG4771	TonB-dependent receptor
A6A11_RS00110	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A6A11_RS00115	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
A6A11_RS00125	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
A6A11_RS00130	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A6A11_RS00175	COG1309	transcriptional regulator
A6A11_RS00180	COG0583	DNA-binding transcription factor activity
A6A11_RS00185	COG0678	peroxiredoxin activity
A6A11_RS00185	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A6A11_RS00195	COG0545	Peptidyl-prolyl cis-trans isomerase
A6A11_RS00205	COG2923	Belongs to the DsrF TusC family
A6A11_RS00220	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
A6A11_RS00240	COG0019	diaminopimelate decarboxylase activity
A6A11_RS00245	COG0552	protein localization to endoplasmic reticulum
A6A11_RS00250	COG0742	ribosomal rna small subunit methyltransferase
A6A11_RS00255	COG0758	DNA mediated transformation
A6A11_RS00265	COG3074	FtsZ-dependent cytokinesis
A6A11_RS00270	COG1494	fructose-1,6-bisphosphatase
A6A11_RS00275	COG0187	DNA topoisomerase II activity
A6A11_RS00285	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
A6A11_RS00290	COG0235	Class ii aldolase
A6A11_RS00295	COG3623	hexulose-6-phosphate isomerase
A6A11_RS00320	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
A6A11_RS00325	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
A6A11_RS00330	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A6A11_RS00335	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A6A11_RS00340	COG1381	Involved in DNA repair and RecF pathway recombination
A6A11_RS00345	COG1132	(ABC) transporter
A6A11_RS00355	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A6A11_RS00375	COG4942	peptidase
A6A11_RS00380	COG2861	carbohydrate metabolic process
A6A11_RS00385	COG0606	chelatase, subunit chli
A6A11_RS00395	COG0218	Necessary for normal cell division and for the maintenance of normal septation
A6A11_RS00400	COG2990	Protein conserved in bacteria
A6A11_RS00410	COG2195	Cleaves the N-terminal amino acid of tripeptides
A6A11_RS00420	COG1476	TRANSCRIPTIONal
A6A11_RS00440	COG0248	Ppx GppA phosphatase
A6A11_RS00445	COG2911	Protein conserved in bacteria
A6A11_RS00450	COG0729	surface antigen
A6A11_RS00455	COG2197	response regulator
A6A11_RS00465	COG0181	hydroxymethylbilane synthase activity
A6A11_RS00475	COG2959	enzyme of heme biosynthesis
A6A11_RS00480	COG3071	HemY protein
A6A11_RS00485	COG0733	neurotransmitter:sodium symporter activity
A6A11_RS00495	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A6A11_RS00505	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A6A11_RS00510	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A6A11_RS00515	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
A6A11_RS00520	COG3719	Belongs to the RNase T2 family
A6A11_RS00525	COG0126	phosphoglycerate kinase activity
A6A11_RS00530	COG0191	fructose-bisphosphate aldolase activity
A6A11_RS00545	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
A6A11_RS00550	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
A6A11_RS00560	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A6A11_RS00570	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
A6A11_RS00590	COG0201	protein transport
A6A11_RS00610	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A6A11_RS00620	COG0203	ribosomal protein L17
A6A11_RS00625	COG1629	transport
A6A11_RS00625	COG4771	TonB-dependent receptor
A6A11_RS00630	COG0242	peptide deformylase activity
A6A11_RS00645	COG0569	domain protein
A6A11_RS00655	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
A6A11_RS00675	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6A11_RS00675	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6A11_RS00680	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A6A11_RS00680	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A6A11_RS00680	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
A6A11_RS00690	COG1595	DNA-templated transcription, initiation
A6A11_RS00695	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
A6A11_RS00700	COG3026	antisigma factor binding
A6A11_RS00705	COG3086	response to oxidative stress
A6A11_RS00710	COG1763	Mo-molybdopterin cofactor biosynthetic process
A6A11_RS00715	COG2814	Major facilitator Superfamily
A6A11_RS00730	COG1522	sequence-specific DNA binding
A6A11_RS00735	COG1349	DNA-binding transcription factor activity
A6A11_RS00740	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
A6A11_RS00745	COG1070	Carbohydrate kinase
A6A11_RS00755	COG0235	Class ii aldolase
A6A11_RS00760	COG1129	ABC transporter
A6A11_RS00765	COG1172	Belongs to the binding-protein-dependent transport system permease family
A6A11_RS00770	COG1879	ABC-type sugar transport system periplasmic component
A6A11_RS00775	COG1454	alcohol dehydrogenase
A6A11_RS00780	COG1629	transport
A6A11_RS00780	COG4206	TonB-dependent receptor
A6A11_RS00785	COG2129	metallophosphoesterase
A6A11_RS00790	COG3172	ATPase kinase involved in NAD metabolism
A6A11_RS00795	COG2960	long-chain fatty acid transporting porin activity
A6A11_RS00805	COG2267	carboxylic ester hydrolase activity
A6A11_RS00810	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A6A11_RS00815	COG0561	phosphatase activity
A6A11_RS00825	COG3978	acetolactate synthase activity
A6A11_RS00840	COG1760	l-serine dehydratase
A6A11_RS00845	COG0814	amino acid
A6A11_RS00850	COG0433	COG0433 Predicted ATPase
A6A11_RS00860	COG1295	ribonuclease BN
A6A11_RS00865	COG1490	D-aminoacyl-tRNA deacylase activity
A6A11_RS00870	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A6A11_RS00880	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
A6A11_RS00890	COG1561	YicC-like family, N-terminal region
A6A11_RS00895	COG0354	folic acid binding
A6A11_RS00900	COG5645	(Lipo)protein
A6A11_RS00905	COG0210	DNA helicase
A6A11_RS00925	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A6A11_RS00940	COG0861	Integral membrane protein TerC family
A6A11_RS00950	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A6A11_RS00960	COG3691	Protein conserved in bacteria
A6A11_RS00970	COG4178	(ABC) transporter
A6A11_RS00985	COG1309	transcriptional regulator
A6A11_RS00990	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6A11_RS00995	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A6A11_RS01005	COG0560	Phosphoserine phosphatase
A6A11_RS01015	COG2095	MarC family integral membrane protein
A6A11_RS01030	COG1027	Aspartate ammonia-lyase
A6A11_RS01060	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
A6A11_RS01070	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A6A11_RS01080	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A6A11_RS01100	COG0006	proline dipeptidase activity
A6A11_RS01105	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A6A11_RS01110	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A6A11_RS01115	COG1072	(Pantothenic acid kinase))
A6A11_RS01145	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A6A11_RS01155	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A6A11_RS01175	COG0085	RNA polymerase activity
A6A11_RS01190	COG1187	pseudouridine synthase activity
A6A11_RS01195	COG0538	isocitrate dehydrogenase activity
A6A11_RS01200	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A6A11_RS01210	COG0705	Rhomboid family
A6A11_RS01215	COG0402	S-adenosylhomocysteine deaminase activity
A6A11_RS01220	COG3083	sulfuric ester hydrolase activity
A6A11_RS01235	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A6A11_RS01240	COG0745	RESPONSE REGULATOR receiver
A6A11_RS01245	COG2205	protein histidine kinase activity
A6A11_RS01255	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A6A11_RS01260	COG1879	ABC-type sugar transport system periplasmic component
A6A11_RS01265	COG1172	Belongs to the binding-protein-dependent transport system permease family
A6A11_RS01275	COG1869	D-ribose catabolic process
A6A11_RS01280	COG1720	tRNA m6t6A37 methyltransferase activity
A6A11_RS01285	COG1575	Belongs to the MenA family. Type 1 subfamily
A6A11_RS01290	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
A6A11_RS01295	COG0471	metal ion transport
A6A11_RS01300	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A6A11_RS01305	COG2818	Glycosylase
A6A11_RS01310	COG2194	sulfuric ester hydrolase activity
A6A11_RS01360	COG4964	Belongs to the GSP D family
A6A11_RS01395	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
A6A11_RS01455	COG0512	Glutamine amidotransferase of anthranilate synthase
A6A11_RS01475	COG0594	ribonuclease P activity
A6A11_RS01485	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A6A11_RS01490	COG0592	DNA-directed DNA polymerase activity
A6A11_RS01495	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A6A11_RS01500	COG2226	methyltransferase
A6A11_RS01535	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A6A11_RS01540	COG3340	Belongs to the peptidase S51 family
A6A11_RS01545	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A6A11_RS01555	COG0326	Molecular chaperone. Has ATPase activity
A6A11_RS01565	COG3036	rescue of stalled ribosome
A6A11_RS01575	COG1393	Belongs to the ArsC family
A6A11_RS01585	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
A6A11_RS01595	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
A6A11_RS01610	COG0436	Aminotransferase
A6A11_RS01630	COG1388	LysM domain
A6A11_RS01630	COG4942	peptidase
A6A11_RS01640	COG1238	metal cluster binding
A6A11_RS01655	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
A6A11_RS01660	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A6A11_RS01660	COG0475	glutathione-regulated potassium exporter activity
A6A11_RS01685	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A6A11_RS01695	COG0762	integral membrane protein
A6A11_RS01710	COG3691	Protein conserved in bacteria
A6A11_RS01715	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A6A11_RS01735	COG4785	May be involved in cell division
A6A11_RS01740	COG0513	Belongs to the DEAD box helicase family
A6A11_RS01745	COG2081	HI0933 family
A6A11_RS01750	COG0564	pseudouridine synthase activity
A6A11_RS01755	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
A6A11_RS01770	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
A6A11_RS01780	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A6A11_RS01785	COG0805	protein transport
A6A11_RS01815	COG2369	cell adhesion
A6A11_RS01825	COG0747	negative chemotaxis
A6A11_RS01830	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A6A11_RS01845	COG0330	HflC and HflK could
A6A11_RS01850	COG0330	HflC and HflK could
A6A11_RS01855	COG3028	Belongs to the UPF0307 family
A6A11_RS01860	COG0312	modulator of DNA gyrase
A6A11_RS01865	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
A6A11_RS01875	COG1271	oxidase subunit
A6A11_RS01880	COG1294	oxidase, subunit
A6A11_RS01895	COG0824	Thioesterase
A6A11_RS01900	COG0811	peptide transport
A6A11_RS01905	COG0848	biopolymer transport protein
A6A11_RS01910	COG3064	Membrane
A6A11_RS01945	COG2165	general secretion pathway protein
A6A11_RS01950	COG4795	General secretion pathway protein
A6A11_RS01965	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
A6A11_RS01975	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A6A11_RS01980	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A6A11_RS01985	COG0084	hydrolase, TatD family'
A6A11_RS01990	COG0602	queuosine metabolic process
A6A11_RS01995	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A6A11_RS01995	COG1328	CTP reductase activity
A6A11_RS02000	COG0730	response to heat
A6A11_RS02005	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A6A11_RS02010	COG3119	arylsulfatase activity
A6A11_RS02015	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A6A11_RS02020	COG0641	radical SAM
A6A11_RS02025	COG0799	negative regulation of ribosome biogenesis
A6A11_RS02035	COG0768	penicillin binding
A6A11_RS02040	COG0772	Belongs to the SEDS family
A6A11_RS02045	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A6A11_RS02045	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A6A11_RS02050	COG1686	Belongs to the peptidase S11 family
A6A11_RS02075	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
A6A11_RS02080	COG4536	flavin adenine dinucleotide binding
A6A11_RS02085	COG4137	Cytochrome C assembly protein
A6A11_RS02090	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A6A11_RS02110	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A6A11_RS02115	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A6A11_RS02120	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
A6A11_RS02160	COG0165	Argininosuccinate lyase
A6A11_RS02165	COG0745	RESPONSE REGULATOR receiver
A6A11_RS02180	COG1126	abc transporter atp-binding protein
A6A11_RS02185	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6A11_RS02190	COG4215	(ABC) transporter
A6A11_RS02195	COG4160	amino acid transport
A6A11_RS02200	COG1368	sulfuric ester hydrolase activity
A6A11_RS02215	COG0281	malic enzyme
A6A11_RS02215	COG0280	phosphate acetyltransferase
A6A11_RS02225	COG0435	Glutathione S-transferase
A6A11_RS02230	COG2610	gluconate transmembrane transporter activity
A6A11_RS02235	COG3265	gluconokinase activity
A6A11_RS02240	COG1609	Transcriptional regulator
A6A11_RS02245	COG1349	DNA-binding transcription factor activity
A6A11_RS02255	COG0747	negative chemotaxis
A6A11_RS02260	COG0601	transmembrane transport
A6A11_RS02265	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A6A11_RS02270	COG0444	Belongs to the ABC transporter superfamily
A6A11_RS02275	COG4608	Belongs to the ABC transporter superfamily
A6A11_RS02295	COG3161	chorismate lyase activity
A6A11_RS02310	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A6A11_RS02335	COG1138	Cytochrome C-type biogenesis protein
A6A11_RS02345	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A6A11_RS02350	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A6A11_RS02355	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A6A11_RS02360	COG4133	protoheme IX ABC transporter activity
A6A11_RS02400	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A6A11_RS02410	COG2990	Protein conserved in bacteria
A6A11_RS02415	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
A6A11_RS02420	COG0539	negative regulation of cytoplasmic translation
A6A11_RS02425	COG0776	regulation of translation
A6A11_RS02430	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
A6A11_RS02435	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
A6A11_RS02445	COG0023	Translation Initiation Factor
A6A11_RS02450	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A6A11_RS02455	COG1288	antiporter activity
A6A11_RS02460	COG3094	Invasion gene expression up-regulator, SirB
A6A11_RS02465	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A6A11_RS02475	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A6A11_RS02490	COG0076	glutamate decarboxylase activity
A6A11_RS02495	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A6A11_RS02500	COG5413	integral membrane protein
A6A11_RS02510	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A6A11_RS02515	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A6A11_RS02520	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A6A11_RS02530	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
A6A11_RS02545	COG3091	SprT-like family
A6A11_RS02550	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
A6A11_RS02555	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
A6A11_RS02560	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
A6A11_RS02565	COG0351	phosphomethylpyrimidine kinase
A6A11_RS02570	COG4143	(ABC) transporter
A6A11_RS02575	COG1178	ABC-type Fe3 transport system permease component
A6A11_RS02580	COG1349	DNA-binding transcription factor activity
A6A11_RS02585	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
A6A11_RS02590	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A6A11_RS02615	COG1530	ribonuclease E activity
A6A11_RS02620	COG1944	ATP diphosphatase activity
A6A11_RS02650	COG2190	(PTS) system
A6A11_RS02650	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6A11_RS02650	COG1263	PTS System
A6A11_RS02655	COG0363	glucosamine-6-phosphate deaminase activity
A6A11_RS02660	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
A6A11_RS02685	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A6A11_RS02700	COG0012	GTP binding
A6A11_RS02710	COG0174	glutamine synthetase
A6A11_RS02720	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A6A11_RS02735	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
A6A11_RS02745	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A6A11_RS02750	COG1923	regulation of RNA biosynthetic process
A6A11_RS02760	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
A6A11_RS02765	COG0860	N-Acetylmuramoyl-L-alanine amidase
A6A11_RS02765	COG1388	LysM domain
A6A11_RS02770	COG0802	atpase or kinase
A6A11_RS02780	COG4221	oxidoreductase activity
A6A11_RS02795	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
A6A11_RS02800	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
A6A11_RS02805	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
A6A11_RS02810	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
A6A11_RS02815	COG1177	transmembrane transport
A6A11_RS02820	COG1176	ABC-type spermidine putrescine transport system, permease component I
A6A11_RS02825	COG3842	ATPase activity
A6A11_RS02845	COG3716	PTS system mannose fructose sorbose family IID component
A6A11_RS02850	COG3715	PTS system
A6A11_RS02855	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6A11_RS02855	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6A11_RS02880	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
A6A11_RS02885	COG0497	DNA recombination
A6A11_RS02900	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
A6A11_RS02905	COG0527	aspartate kinase activity
A6A11_RS02925	COG2867	negative regulation of translational initiation
A6A11_RS02935	COG2850	peptidyl-arginine hydroxylation
A6A11_RS02950	COG0575	Belongs to the CDS family
A6A11_RS02965	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
A6A11_RS02970	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A6A11_RS02985	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A6A11_RS02995	COG0490	domain, Protein
A6A11_RS02995	COG0471	metal ion transport
A6A11_RS03000	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A6A11_RS03010	COG4589	Belongs to the CDS family
A6A11_RS03015	COG0521	Mo-molybdopterin cofactor biosynthetic process
A6A11_RS03025	COG0628	permease
A6A11_RS03035	COG3063	Type IV pilus biogenesis stability protein PilW
A6A11_RS03040	COG1426	Protein conserved in bacteria
A6A11_RS03050	COG0124	histidyl-tRNA synthetase
A6A11_RS03055	COG2976	Protein conserved in bacteria
A6A11_RS03080	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A6A11_RS03085	COG1737	Transcriptional regulator
A6A11_RS03090	COG3718	enzyme involved in inositol metabolism
A6A11_RS03100	COG0673	inositol 2-dehydrogenase activity
A6A11_RS03105	COG1879	ABC-type sugar transport system periplasmic component
A6A11_RS03110	COG1129	ABC transporter
A6A11_RS03115	COG1172	Belongs to the binding-protein-dependent transport system permease family
A6A11_RS03130	COG0673	inositol 2-dehydrogenase activity
A6A11_RS03145	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A6A11_RS03150	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A6A11_RS03155	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A6A11_RS03175	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A6A11_RS03250	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A6A11_RS03260	COG1792	Involved in formation and maintenance of cell shape
A6A11_RS03265	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
A6A11_RS03270	COG0815	Transfers the fatty acyl group on membrane lipoproteins
A6A11_RS03280	COG2017	converts alpha-aldose to the beta-anomer
A6A11_RS03290	COG1085	galactose-1-phosphate uridylyltransferase
A6A11_RS03295	COG1609	Transcriptional regulator
A6A11_RS03300	COG1879	ABC-type sugar transport system periplasmic component
A6A11_RS03310	COG4211	Belongs to the binding-protein-dependent transport system permease family
A6A11_RS03315	COG1929	Belongs to the glycerate kinase type-1 family
A6A11_RS03325	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A6A11_RS03330	COG3647	Membrane
A6A11_RS03340	COG0295	cytidine deaminase activity
A6A11_RS03355	COG3274	enterobacterial common antigen metabolic process
A6A11_RS03385	COG2350	Protein conserved in bacteria
A6A11_RS03390	COG1607	acyl-coa hydrolase
A6A11_RS03395	COG2917	probably involved in intracellular septation
A6A11_RS03455	COG1083	cytidylyl-transferase
A6A11_RS03460	COG2927	DNA polymerase III (CHI subunit)
A6A11_RS03465	COG0525	valine-tRNA ligase activity
A6A11_RS03480	COG1335	isochorismatase
A6A11_RS03490	COG5295	Hep Hag repeat protein
A6A11_RS03490	COG5295	Hep Hag repeat protein
A6A11_RS03495	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A6A11_RS03515	COG0489	protein tyrosine kinase activity
A6A11_RS03520	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6A11_RS03520	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6A11_RS03530	COG1793	dna ligase
A6A11_RS03540	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A6A11_RS03550	COG2194	sulfuric ester hydrolase activity
A6A11_RS03565	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
A6A11_RS03570	COG0800	Aldolase
A6A11_RS03580	COG0456	acetyltransferase
A6A11_RS03585	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
A6A11_RS03590	COG2813	Specifically methylates the guanine in position
A6A11_RS03615	COG1278	Cold shock
A6A11_RS03625	COG1053	succinate dehydrogenase
A6A11_RS03630	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A6A11_RS03650	COG0795	lipopolysaccharide-transporting ATPase activity
A6A11_RS03655	COG0795	lipopolysaccharide-transporting ATPase activity
A6A11_RS03845	COG1705	Flagellar rod assembly protein muramidase FlgJ
A6A11_RS03845	COG3951	Flagellar rod assembly protein muramidase FlgJ
A6A11_RS03925	COG0789	Transcriptional regulator
A6A11_RS03935	COG0009	L-threonylcarbamoyladenylate synthase
A6A11_RS03945	COG0814	amino acid
A6A11_RS03960	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
A6A11_RS03965	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
A6A11_RS03970	COG1280	lysine exporter protein (LysE YggA)
A6A11_RS03975	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
A6A11_RS03980	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
A6A11_RS03985	COG4172	Belongs to the ABC transporter superfamily
A6A11_RS03990	COG4172	Belongs to the ABC transporter superfamily
A6A11_RS03995	COG4171	peptide transport system, permease
A6A11_RS04000	COG4168	peptide transport system, permease
A6A11_RS04005	COG4166	transmembrane transport
A6A11_RS04010	COG3106	COG3106 Predicted ATPase
A6A11_RS04020	COG3283	Transcriptional regulator of aromatic amino acids metabolism
A6A11_RS04025	COG3105	Protein conserved in bacteria
A6A11_RS04030	COG2268	Band 7 protein
A6A11_RS04040	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
A6A11_RS04045	COG1687	branched-chain amino acid
A6A11_RS04050	COG0633	Ferredoxin
A6A11_RS04050	COG3217	Mosc domain protein beta barrel domain protein
A6A11_RS04055	COG2027	D-alanyl-D-alanine carboxypeptidase
A6A11_RS04065	COG1534	Rna-binding protein
A6A11_RS04070	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
A6A11_RS04075	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A6A11_RS04080	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A6A11_RS04090	COG2062	phosphohistidine phosphatase, SixA
A6A11_RS04095	COG2823	Periplasmic or secreted lipoprotein
A6A11_RS04100	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
A6A11_RS04110	COG3107	peptidoglycan biosynthetic process
A6A11_RS04120	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A6A11_RS04130	COG0741	lytic transglycosylase activity
A6A11_RS04135	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A6A11_RS04140	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A6A11_RS04145	COG1862	Preprotein translocase
A6A11_RS04170	COG2831	hemolysin activation secretion protein
A6A11_RS04175	COG3210	domain, Protein
A6A11_RS04425	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A6A11_RS04430	COG1946	Acyl-CoA thioesterase
A6A11_RS04440	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
A6A11_RS04445	COG4988	ABC transporter
A6A11_RS04450	COG0492	ferredoxin-NADP+ reductase activity
A6A11_RS04460	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
A6A11_RS04475	COG1289	transmembrane transporter activity
A6A11_RS04495	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A6A11_RS04500	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A6A11_RS04505	COG1121	(ABC) transporter
A6A11_RS04515	COG2920	part of a sulfur-relay system
A6A11_RS04520	COG0670	Belongs to the BI1 family
A6A11_RS04530	COG2831	hemolysin activation secretion protein
A6A11_RS04535	COG3210	domain, Protein
A6A11_RS04575	COG3099	Belongs to the UPF0263 family
A6A11_RS04580	COG1116	anion transmembrane transporter activity
A6A11_RS04585	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A6A11_RS04590	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A6A11_RS04595	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
A6A11_RS04600	COG0352	thiamine-phosphate diphosphorylase activity
A6A11_RS04610	COG0210	DNA helicase
A6A11_RS04620	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A6A11_RS04630	COG2005	Transcriptional regulator
A6A11_RS04635	COG0725	ABC transporter, periplasmic molybdate-binding protein
A6A11_RS04640	COG4149	molybdate abc transporter
A6A11_RS04645	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
A6A11_RS04650	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A6A11_RS04660	COG0739	heme binding
A6A11_RS04670	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
A6A11_RS04675	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
A6A11_RS04680	COG0617	tRNA 3'-terminal CCA addition
A6A11_RS04685	COG4991	sh3 domain protein
A6A11_RS04690	COG0306	phosphate transporter
A6A11_RS04695	COG1392	Phosphate transport regulator
A6A11_RS04700	COG3025	triphosphatase activity
A6A11_RS04705	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
A6A11_RS04710	COG1522	sequence-specific DNA binding
A6A11_RS04725	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A6A11_RS04745	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A6A11_RS04745	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A6A11_RS04750	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A6A11_RS04755	COG0339	signal peptide processing
A6A11_RS04760	COG2832	Protein of unknown function (DUF454)
A6A11_RS04765	COG4166	transmembrane transport
A6A11_RS04775	COG0037	tRNA processing
A6A11_RS04795	COG2274	protein secretion by the type I secretion system
A6A11_RS04800	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6A11_RS04810	COG0825	malonyl-CoA metabolic process
A6A11_RS04815	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A6A11_RS04820	COG0671	phosphoesterase, PA-phosphatase related
A6A11_RS04825	COG1070	Carbohydrate kinase
A6A11_RS04830	COG1940	carbohydrate kinase activity
A6A11_RS04845	COG1172	Belongs to the binding-protein-dependent transport system permease family
A6A11_RS04855	COG0784	Response regulator, receiver
A6A11_RS04855	COG4191	Histidine kinase
A6A11_RS04860	COG1940	carbohydrate kinase activity
A6A11_RS04865	COG1115	amino acid carrier protein
A6A11_RS04880	COG0515	serine threonine protein kinase
A6A11_RS04895	COG0195	Participates in both transcription termination and antitermination
A6A11_RS04915	COG0583	DNA-binding transcription factor activity
A6A11_RS04920	COG2259	Doxx family
A6A11_RS04925	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A6A11_RS04935	COG1741	Belongs to the pirin family
A6A11_RS04965	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6A11_RS04970	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A6A11_RS04975	COG2190	(PTS) system
A6A11_RS04980	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
A6A11_RS04985	COG0508	dehydrogenase complex catalyzes the overall conversion of
A6A11_RS04990	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A6A11_RS05000	COG3381	protein complex oligomerization
A6A11_RS05005	COG2249	NAD(P)H dehydrogenase (quinone) activity
A6A11_RS05015	COG0330	HflC and HflK could
A6A11_RS05025	COG2932	Transcriptional regulator
A6A11_RS05035	COG0791	NLP P60 protein
A6A11_RS05040	COG1560	Kdo2-lipid A biosynthetic process
A6A11_RS05045	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
A6A11_RS05045	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A6A11_RS05050	COG1525	nuclease
A6A11_RS05055	COG0488	(ABC) transporter
A6A11_RS05060	COG3683	transport system, periplasmic component
A6A11_RS05065	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
A6A11_RS05085	COG1448	Aminotransferase
A6A11_RS05090	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
A6A11_RS05095	COG0288	reversible hydration of carbon dioxide
A6A11_RS05100	COG1349	DNA-binding transcription factor activity
A6A11_RS05105	COG2222	sugar isomerase
A6A11_RS05120	COG3716	PTS system mannose fructose sorbose family IID component
A6A11_RS05125	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A6A11_RS05140	COG3684	Belongs to the aldolase LacD family
A6A11_RS05145	COG0616	signal peptide processing
A6A11_RS05160	COG2999	glutathione oxidoreductase activity
A6A11_RS05175	COG3101	peptidyl-lysine hydroxylation
A6A11_RS05180	COG1131	(ABC) transporter
A6A11_RS05185	COG0842	Transport permease protein
A6A11_RS05190	COG0004	ammonium transporteR
A6A11_RS05195	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A6A11_RS05205	COG0142	geranyltranstransferase activity
A6A11_RS05215	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A6A11_RS05215	COG0301	tRNA thio-modification
A6A11_RS05225	COG1278	Cold shock
A6A11_RS05235	COG1067	ATP-dependent peptidase activity
A6A11_RS05255	COG0791	NLP P60 protein
A6A11_RS05270	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A6A11_RS05275	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A6A11_RS05285	COG0285	dihydrofolate synthase activity
A6A11_RS05290	COG0564	pseudouridine synthase activity
A6A11_RS05295	COG0586	Pfam SNARE associated Golgi protein
A6A11_RS05300	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
A6A11_RS05305	COG0101	tRNA pseudouridine synthase activity
A6A11_RS05310	COG4771	TonB-dependent receptor
A6A11_RS05315	COG0613	PHP domain protein
A6A11_RS05330	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
A6A11_RS05345	COG0697	spore germination
A6A11_RS05350	COG2925	Exonuclease
A6A11_RS05365	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A6A11_RS05375	COG3005	denitrification pathway
A6A11_RS05380	COG0243	molybdopterin cofactor binding
A6A11_RS05390	COG0167	dihydroorotate dehydrogenase activity
A6A11_RS05395	COG0308	aminopeptidase N
A6A11_RS05415	COG1523	belongs to the glycosyl hydrolase 13 family
A6A11_RS05425	COG1640	4-alpha-glucanotransferase
A6A11_RS05455	COG1538	Outer membrane efflux protein
A6A11_RS05465	COG0314	molybdopterin synthase activity
A6A11_RS05470	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
A6A11_RS05480	COG0303	'Molybdopterin
A6A11_RS05485	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A6A11_RS05490	COG2259	Doxx family
A6A11_RS05500	COG3220	belongs to the UPF0276 family
A6A11_RS05505	COG3219	Protein conserved in bacteria
A6A11_RS05510	COG1595	DNA-templated transcription, initiation
A6A11_RS05520	COG0673	inositol 2-dehydrogenase activity
A6A11_RS05530	COG0604	alcohol dehydrogenase
A6A11_RS05535	COG1528	Iron-storage protein
A6A11_RS05540	COG1528	Iron-storage protein
A6A11_RS05565	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A6A11_RS05575	COG3593	DNA synthesis involved in DNA repair
A6A11_RS05580	COG1605	Chorismate mutase
A6A11_RS05580	COG0287	Prephenate dehydrogenase
A6A11_RS05585	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A6A11_RS05590	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A6A11_RS05595	COG2431	L-lysine efflux transmembrane transporter activity
A6A11_RS05605	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
A6A11_RS05610	COG0291	Belongs to the bacterial ribosomal protein bL35 family
A6A11_RS05620	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A6A11_RS05625	COG0589	response to stress
A6A11_RS05630	COG0616	signal peptide processing
A6A11_RS05635	COG0778	Nitroreductase
A6A11_RS05645	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A6A11_RS05660	COG3098	single-species biofilm formation
A6A11_RS05665	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
A6A11_RS05675	COG1611	Belongs to the LOG family
A6A11_RS05700	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A6A11_RS05720	COG0708	Exodeoxyribonuclease III
A6A11_RS05725	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
A6A11_RS05735	COG0517	IMP dehydrogenase activity
A6A11_RS05735	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
A6A11_RS05740	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
A6A11_RS05755	COG0697	spore germination
A6A11_RS05765	COG3030	protein affecting phage T7 exclusion by the F plasmid
A6A11_RS05775	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A6A11_RS05780	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A6A11_RS05790	COG1598	PFAM Uncharacterised protein family UPF0150
A6A11_RS05815	COG1940	carbohydrate kinase activity
A6A11_RS05825	COG2969	positive regulation of protein catabolic process
A6A11_RS05855	COG0121	glutamine amidotransferase
A6A11_RS05865	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A6A11_RS05870	COG1074	ATP-dependent DNA helicase activity
A6A11_RS05885	COG0395	ABC-type sugar transport system, permease component
A6A11_RS05890	COG1175	transmembrane transport
A6A11_RS05895	COG3842	ATPase activity
A6A11_RS05900	COG0584	glycerophosphoryl diester phosphodiesterase
A6A11_RS05905	COG2252	PERMEase
A6A11_RS05910	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A6A11_RS05915	COG0163	prenyltransferase activity
A6A11_RS05925	COG1286	toxin biosynthetic process
A6A11_RS05940	COG0280	phosphate acetyltransferase
A6A11_RS05940	COG0857	belongs to the CobB CobQ family
A6A11_RS05945	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
A6A11_RS05950	COG0318	PFAM AMP-dependent synthetase and ligase
A6A11_RS05955	COG3065	identical protein binding
A6A11_RS05960	COG1214	PFAM Peptidase M22, glycoprotease
A6A11_RS05965	COG1199	ATP-dependent helicase activity
A6A11_RS05970	COG0676	glucose-6-phosphate 1-epimerase activity
A6A11_RS05975	COG2951	lytic endotransglycosylase activity
A6A11_RS05980	COG1858	cytochrome C peroxidase
A6A11_RS05985	COG1216	Glycosyl transferase, family 2
A6A11_RS05990	COG1216	Glycosyl transferase, family 2
A6A11_RS06000	COG3306	glycosyltransferase involved in LPS biosynthesis
A6A11_RS06010	COG5039	Polysaccharide pyruvyl transferase
A6A11_RS06015	COG1434	Gram-negative-bacterium-type cell wall biogenesis
A6A11_RS06020	COG0469	pyruvate kinase activity
A6A11_RS06045	COG1337	RAMP superfamily
A6A11_RS06080	COG1518	maintenance of DNA repeat elements
A6A11_RS06085	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
A6A11_RS06100	COG0024	Methionine aminopeptidase
A6A11_RS06105	COG0316	Belongs to the HesB IscA family
A6A11_RS06110	COG3112	Uncharacterised protein family (UPF0231)
A6A11_RS06115	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A6A11_RS06120	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
A6A11_RS06125	COG0583	DNA-binding transcription factor activity
A6A11_RS06130	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A6A11_RS06140	COG3008	intermembrane lipid transfer
A6A11_RS06145	COG2995	paraquat-inducible protein a
A6A11_RS06155	COG2864	formate dehydrogenase
A6A11_RS06160	COG0437	4 iron, 4 sulfur cluster binding
A6A11_RS06165	COG3383	formate dehydrogenase (NAD+) activity
A6A11_RS06165	COG0243	molybdopterin cofactor binding
A6A11_RS06170	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
A6A11_RS06175	COG1757	Na H antiporter
A6A11_RS06180	COG0788	formyltetrahydrofolate deformylase activity
A6A11_RS06185	COG0307	riboflavin synthase, alpha
A6A11_RS06195	COG0443	Heat shock 70 kDa protein
A6A11_RS06205	COG0484	heat shock protein binding
A6A11_RS06215	COG0583	DNA-binding transcription factor activity
A6A11_RS06235	COG1704	LemA family
A6A11_RS06245	COG0247	lactate metabolic process
A6A11_RS06245	COG0277	FAD linked oxidase domain protein
A6A11_RS06260	COG1840	ABC-type Fe3 transport system, periplasmic component
A6A11_RS06265	COG0395	ABC-type sugar transport system, permease component
A6A11_RS06270	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
A6A11_RS06280	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
A6A11_RS06285	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
A6A11_RS06300	COG1643	Atp-dependent helicase
A6A11_RS06305	COG2363	Small membrane protein
A6A11_RS06315	COG2837	iron assimilation
A6A11_RS06335	COG0305	Participates in initiation and elongation during chromosome replication
A6A11_RS06340	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A6A11_RS06345	COG4591	ABC-type transport system involved in lipoprotein release permease component
A6A11_RS06350	COG1136	(ABC) transporter
A6A11_RS06355	COG4591	ABC-type transport system involved in lipoprotein release permease component
A6A11_RS06360	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A6A11_RS06380	COG1714	RDD family
A6A11_RS06390	COG3133	Outer membrane lipoprotein
A6A11_RS06400	COG3102	Protein conserved in bacteria
A6A11_RS06410	COG0039	L-malate dehydrogenase activity
A6A11_RS06415	COG1438	arginine binding
A6A11_RS06420	COG1090	epimerase
A6A11_RS06425	COG4657	Part of a membrane complex involved in electron transport
A6A11_RS06440	COG4658	electron transport chain
A6A11_RS06455	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A6A11_RS06460	COG0733	neurotransmitter:sodium symporter activity
A6A11_RS06480	COG3118	belongs to the thioredoxin family
A6A11_RS06490	COG2207	Transcriptional regulator
A6A11_RS06495	COG0508	dehydrogenase complex catalyzes the overall conversion of
A6A11_RS06500	COG0567	Dehydrogenase, E1 component
A6A11_RS06515	COG1979	alcohol dehydrogenase
A6A11_RS06520	COG1309	transcriptional regulator
A6A11_RS06525	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
A6A11_RS06545	COG0732	type I restriction modification DNA specificity domain
A6A11_RS06550	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
A6A11_RS06555	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A6A11_RS06560	COG3108	Peptidase M15
A6A11_RS06565	COG2989	Protein conserved in bacteria
A6A11_RS06570	COG0793	Belongs to the peptidase S41A family
A6A11_RS06575	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
A6A11_RS06625	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
A6A11_RS06630	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A6A11_RS06640	COG1346	cytolysis
A6A11_RS06645	COG1380	Effector of murein hydrolase LrgA
A6A11_RS06650	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A6A11_RS06655	COG2166	iron-sulfur cluster assembly
A6A11_RS06660	COG1620	l-lactate permease
A6A11_RS06665	COG1304	FMN binding
A6A11_RS06670	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A6A11_RS06675	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A6A11_RS06680	COG0633	Ferredoxin
A6A11_RS06730	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
A6A11_RS06730	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
A6A11_RS06745	COG0519	Catalyzes the synthesis of GMP from XMP
A6A11_RS06745	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A6A11_RS06785	COG4176	ABC-type proline glycine betaine transport system permease component
A6A11_RS06800	COG0778	Nitroreductase
A6A11_RS06805	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A6A11_RS06810	COG0738	Major facilitator superfamily
A6A11_RS06825	COG0322	excinuclease ABC activity
A6A11_RS06830	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
A6A11_RS06840	COG1663	tetraacyldisaccharide 4'-kinase activity
A6A11_RS06845	COG1132	(ABC) transporter
A6A11_RS06850	COG0658	competence protein
A6A11_RS06850	COG2333	competence protein COMEC
A6A11_RS06855	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A6A11_RS06860	COG0617	tRNA 3'-terminal CCA addition
A6A11_RS06865	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A6A11_RS06875	COG2949	membrane
A6A11_RS06880	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
A6A11_RS06885	COG0494	nUDIX hydrolase
A6A11_RS06890	COG1876	peptidase activity
A6A11_RS06895	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A6A11_RS06900	COG1393	Belongs to the ArsC family
A6A11_RS06905	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
A6A11_RS06910	COG0083	homoserine kinase activity
A6A11_RS06915	COG0527	aspartate kinase activity
A6A11_RS06915	COG0460	homoserine dehydrogenase
A6A11_RS06920	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A6A11_RS06930	COG5007	Belongs to the BolA IbaG family
A6A11_RS06940	COG2854	intermembrane phospholipid transfer
A6A11_RS06945	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
A6A11_RS06950	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A6A11_RS06955	COG1127	ABC transporter
A6A11_RS06960	COG3117	lipopolysaccharide transmembrane transporter activity
A6A11_RS06965	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
A6A11_RS06970	COG1137	ATPase activity
A6A11_RS06975	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6A11_RS06995	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
A6A11_RS07000	COG0641	radical SAM
A6A11_RS07010	COG0494	nUDIX hydrolase
A6A11_RS07020	COG4106	trans-aconitate 2-methyltransferase activity
A6A11_RS07025	COG1605	Chorismate mutase
A6A11_RS07025	COG0077	Prephenate dehydratase
A6A11_RS07030	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
A6A11_RS07035	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A6A11_RS07040	COG0849	cell division
A6A11_RS07045	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
A6A11_RS07050	COG1181	Belongs to the D-alanine--D-alanine ligase family
A6A11_RS07060	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A6A11_RS07070	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A6A11_RS07080	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A6A11_RS07085	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A6A11_RS07090	COG0768	penicillin binding
A6A11_RS07095	COG3116	cell division
A6A11_RS07110	COG1966	Carbon starvation protein
A6A11_RS07120	COG0003	Pfam Anion-transporting ATPase
A6A11_RS07125	COG1444	tRNA N-acetyltransferase activity
A6A11_RS07140	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6A11_RS07140	COG2190	(PTS) system
A6A11_RS07140	COG1263	PTS System
A6A11_RS07150	COG0814	amino acid
A6A11_RS07155	COG1823	symporter activity
A6A11_RS07160	COG1702	phosphate starvation-inducible protein PhoH
A6A11_RS07165	COG0737	Belongs to the 5'-nucleotidase family
A6A11_RS07170	COG0494	nUDIX hydrolase
A6A11_RS07175	COG0730	response to heat
A6A11_RS07190	COG0590	tRNA wobble adenosine to inosine editing
A6A11_RS07195	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A6A11_RS07205	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
A6A11_RS07210	COG1882	Formate acetyltransferase
A6A11_RS07215	COG2116	formate transmembrane transporter activity
A6A11_RS07220	COG0537	adenosine 5'-monophosphoramidase activity
A6A11_RS07235	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A6A11_RS07260	COG1858	cytochrome C peroxidase
A6A11_RS07270	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
A6A11_RS07275	COG0720	synthase
A6A11_RS07280	COG0602	queuosine metabolic process
A6A11_RS07290	COG2186	Transcriptional regulator
A6A11_RS07295	COG3842	ATPase activity
A6A11_RS07300	COG2182	Extracellular solute-binding protein
A6A11_RS07305	COG1175	transmembrane transport
A6A11_RS07310	COG0395	ABC-type sugar transport system, permease component
A6A11_RS07315	COG0673	inositol 2-dehydrogenase activity
A6A11_RS07320	COG0494	nUDIX hydrolase
A6A11_RS07325	COG0653	protein targeting
A6A11_RS07345	COG0338	D12 class N6 adenine-specific DNA methyltransferase
A6A11_RS07350	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A6A11_RS07360	COG4796	Type ii and iii secretion system protein
A6A11_RS07380	COG4972	Pilus assembly protein
A6A11_RS07385	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
A6A11_RS07390	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
A6A11_RS07395	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A6A11_RS07420	COG1509	lysine 2,3-aminomutase activity
A6A11_RS07425	COG3061	Opacity-associated protein A
A6A11_RS07425	COG3266	domain, Protein
A6A11_RS07445	COG2814	Major facilitator Superfamily
A6A11_RS07450	COG4974	Belongs to the 'phage' integrase family
A6A11_RS07455	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
A6A11_RS07460	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
A6A11_RS07465	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
A6A11_RS07480	COG2814	Major facilitator Superfamily
A6A11_RS07485	COG2252	PERMEase
A6A11_RS07490	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A6A11_RS07490	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
A6A11_RS07495	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A6A11_RS07500	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A6A11_RS07505	COG0151	Belongs to the GarS family
A6A11_RS07530	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A6A11_RS07535	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A6A11_RS07545	COG1560	Kdo2-lipid A biosynthetic process
A6A11_RS07550	COG0730	response to heat
A6A11_RS07555	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
A6A11_RS07565	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
A6A11_RS07565	COG3264	Mechanosensitive ion channel
A6A11_RS07570	COG0318	PFAM AMP-dependent synthetase and ligase
A6A11_RS07575	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
A6A11_RS07580	COG0596	Alpha beta hydrolase
A6A11_RS07590	COG0204	Acyl-transferase
A6A11_RS07600	COG0735	belongs to the Fur family
A6A11_RS07605	COG0716	FMN binding
A6A11_RS07620	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A6A11_RS07625	COG0512	Glutamine amidotransferase of anthranilate synthase
A6A11_RS07635	COG0135	phosphoribosylanthranilate isomerase activity
A6A11_RS07635	COG0134	indole-3-glycerol-phosphate synthase activity
A6A11_RS07640	COG0133	tryptophan synthase activity
A6A11_RS07645	COG0159	tryptophan synthase activity
A6A11_RS07655	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
A6A11_RS07660	COG0437	4 iron, 4 sulfur cluster binding
A6A11_RS07665	COG3301	Polysulphide reductase, NrfD
A6A11_RS07670	COG1138	Cytochrome C-type biogenesis protein
A6A11_RS07675	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A6A11_RS07680	COG3088	subunit of a heme lyase
A6A11_RS07680	COG4235	cytochrome complex assembly
A6A11_RS07685	COG4235	cytochrome complex assembly
A6A11_RS07695	COG3021	interspecies interaction between organisms
A6A11_RS07710	COG0107	imidazoleglycerol-phosphate synthase activity
A6A11_RS07720	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
A6A11_RS07730	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
A6A11_RS07730	COG0131	Imidazoleglycerol-phosphate dehydratase
A6A11_RS07740	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A6A11_RS07755	COG2226	methyltransferase
A6A11_RS07760	COG0814	amino acid
A6A11_RS07785	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
A6A11_RS07800	COG0848	biopolymer transport protein
A6A11_RS07805	COG0811	peptide transport
A6A11_RS07810	COG0633	Ferredoxin
A6A11_RS07815	COG0443	Heat shock 70 kDa protein
A6A11_RS07820	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
A6A11_RS07830	COG0822	iron-sulfur transferase activity
A6A11_RS07840	COG1959	2 iron, 2 sulfur cluster binding
A6A11_RS07845	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
A6A11_RS07855	COG5002	protein histidine kinase activity
A6A11_RS07855	COG2198	Histidine kinase
A6A11_RS07855	COG0784	Response regulator, receiver
A6A11_RS07870	COG0659	secondary active sulfate transmembrane transporter activity
A6A11_RS07880	COG2056	Na+-H+ antiporter family
A6A11_RS07885	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A6A11_RS07890	COG0346	lactoylglutathione lyase activity
A6A11_RS07895	COG0659	secondary active sulfate transmembrane transporter activity
A6A11_RS07905	COG4735	regulation of single-species biofilm formation
A6A11_RS07915	COG0584	glycerophosphoryl diester phosphodiesterase
A6A11_RS07920	COG2271	Major facilitator Superfamily
A6A11_RS07930	COG1349	DNA-binding transcription factor activity
A6A11_RS07940	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
A6A11_RS07945	COG1459	type II secretion system
A6A11_RS07950	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A6A11_RS07955	COG4969	Belongs to the N-Me-Phe pilin family
A6A11_RS07960	COG3023	N-Acetylmuramoyl-L-alanine amidase
A6A11_RS07970	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
A6A11_RS07980	COG4797	methyltransferase
A6A11_RS07980	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A6A11_RS07990	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A6A11_RS07995	COG0697	spore germination
A6A11_RS08010	COG0142	geranyltranstransferase activity
A6A11_RS08015	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A6A11_RS08020	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A6A11_RS08025	COG0187	DNA topoisomerase II activity
A6A11_RS08035	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A6A11_RS08040	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
A6A11_RS08045	COG1115	amino acid carrier protein
A6A11_RS08070	COG1530	ribonuclease E activity
A6A11_RS08100	COG1172	Belongs to the binding-protein-dependent transport system permease family
A6A11_RS08145	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A6A11_RS08150	COG1758	RNA polymerase activity
A6A11_RS08160	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A6A11_RS08170	COG1022	Amp-dependent synthetase and ligase
A6A11_RS08175	COG0513	Belongs to the DEAD box helicase family
A6A11_RS08180	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
A6A11_RS08185	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
A6A11_RS08190	COG0737	Belongs to the 5'-nucleotidase family
A6A11_RS08200	COG1028	Short-chain dehydrogenase reductase Sdr
A6A11_RS08205	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A6A11_RS08215	COG0416	fatty acid biosynthetic process
A6A11_RS08220	COG0333	Belongs to the bacterial ribosomal protein bL32 family
A6A11_RS08225	COG1399	metal-binding, possibly nucleic acid-binding protein
A6A11_RS08235	COG0601	transmembrane transport
A6A11_RS08240	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A6A11_RS08250	COG4608	Belongs to the ABC transporter superfamily
A6A11_RS08260	COG0500	methyltransferase
A6A11_RS08265	COG2830	Protein of unknown function (DUF452)
A6A11_RS08275	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A6A11_RS08280	COG0688	phosphatidylethanolamine metabolic process
A6A11_RS08285	COG1956	GAF domain-containing protein
A6A11_RS08290	COG0545	Peptidyl-prolyl cis-trans isomerase
A6A11_RS08305	COG2853	Lipoprotein
A6A11_RS08320	COG0681	Belongs to the peptidase S26 family
A6A11_RS08370	COG4545	Glutaredoxin-related protein
A6A11_RS08375	COG4804	nuclease activity
A6A11_RS08380	COG0751	glycine-tRNA ligase activity
A6A11_RS08390	COG2965	DNA replication, synthesis of RNA primer
A6A11_RS08395	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A6A11_RS08405	COG0557	exoribonuclease II activity
A6A11_RS08415	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
A6A11_RS08420	COG3610	response to peptide
A6A11_RS08425	COG2966	Psort location CytoplasmicMembrane, score
A6A11_RS08430	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A6A11_RS08445	COG1555	photosystem II stabilization
A6A11_RS08450	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A6A11_RS08460	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A6A11_RS08465	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
A6A11_RS08470	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A6A11_RS08485	COG4316	Uncharacterized protein conserved in bacteria (DUF2251)
A6A11_RS08530	COG4145	pantothenate transmembrane transporter activity
A6A11_RS08535	COG3924	membrane
A6A11_RS08540	COG0439	Biotin carboxylase
A6A11_RS08545	COG0511	ligase activity, forming carbon-carbon bonds
A6A11_RS08560	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A6A11_RS08565	COG0196	riboflavin kinase activity
A6A11_RS08575	COG0728	peptidoglycan biosynthetic process
A6A11_RS08590	COG0564	pseudouridine synthase activity
A6A11_RS08610	COG1011	Hydrolase
A6A11_RS08615	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
A6A11_RS08625	COG0813	purine-nucleoside phosphorylase activity
A6A11_RS08630	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
A6A11_RS08635	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A6A11_RS08640	COG2364	Membrane
A6A11_RS08645	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A6A11_RS08650	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A6A11_RS08655	COG0470	DNA polymerase III
A6A11_RS08660	COG0084	hydrolase, TatD family'
A6A11_RS08670	COG1253	flavin adenine dinucleotide binding
A6A11_RS08675	COG1132	(ABC) transporter
A6A11_RS08680	COG0859	PFAM glycosyl transferase family 9
A6A11_RS08685	COG3642	lipopolysaccharide core region biosynthetic process
A6A11_RS08695	COG1519	Transferase
A6A11_RS08705	COG0456	acetyltransferase
A6A11_RS08710	COG0753	catalase activity
A6A11_RS08725	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A6A11_RS08730	COG3201	nicotinamide mononucleotide transporter
A6A11_RS08740	COG3468	outer membrane autotransporter barrel domain protein
A6A11_RS08740	COG3266	domain, Protein
A6A11_RS08750	COG0513	Belongs to the DEAD box helicase family
A6A11_RS08760	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A6A11_RS08765	COG0668	transmembrane transport
A6A11_RS08785	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
A6A11_RS08795	COG2731	YhcH YjgK YiaL family protein
A6A11_RS08800	COG1737	Transcriptional regulator
A6A11_RS08805	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A6A11_RS08810	COG2937	Belongs to the GPAT DAPAT family
A6A11_RS08820	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
A6A11_RS08825	COG2267	carboxylic ester hydrolase activity
A6A11_RS08830	COG1466	dna polymerase III delta subunit
A6A11_RS08835	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
A6A11_RS08840	COG0495	leucyl-tRNA aminoacylation
A6A11_RS08855	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A6A11_RS08860	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
A6A11_RS08890	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
A6A11_RS08895	COG1011	Hydrolase
A6A11_RS08905	COG0583	DNA-binding transcription factor activity
A6A11_RS08910	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A6A11_RS08915	COG0494	nUDIX hydrolase
A6A11_RS08920	COG1297	OPT oligopeptide transporter protein
A6A11_RS08930	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
A6A11_RS08935	COG1218	3'(2'),5'-bisphosphate nucleotidase
A6A11_RS08940	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A6A11_RS08945	COG0363	glucosamine-6-phosphate deaminase activity
A6A11_RS08950	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
A6A11_RS08955	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
A6A11_RS08960	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
A6A11_RS08965	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A6A11_RS08970	COG2177	Part of the ABC transporter FtsEX involved in
A6A11_RS08975	COG2884	Cell division ATP-binding protein ftsE
A6A11_RS08990	COG2991	Protein conserved in bacteria
A6A11_RS08995	COG1477	protein flavinylation
A6A11_RS09000	COG2871	sodium ion transport
A6A11_RS09010	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
A6A11_RS09025	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
A6A11_RS09030	COG0271	Belongs to the BolA IbaG family
A6A11_RS09040	COG2860	membrane
A6A11_RS09065	COG1194	a g-specific adenine glycosylase
A6A11_RS09075	COG3171	Protein conserved in bacteria
A6A11_RS09080	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A6A11_RS09080	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A6A11_RS09090	COG0335	large ribosomal subunit rRNA binding
A6A11_RS09105	COG0228	four-way junction DNA binding
A6A11_RS09110	COG0859	PFAM glycosyl transferase family 9
A6A11_RS09115	COG0463	Glycosyl transferase, family 2
A6A11_RS09125	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
A6A11_RS09130	COG0235	Class ii aldolase
A6A11_RS09135	COG3623	hexulose-6-phosphate isomerase
A6A11_RS09160	COG1129	ABC transporter
A6A11_RS09165	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A6A11_RS09170	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
A6A11_RS09175	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
A6A11_RS09180	COG2731	YhcH YjgK YiaL family protein
A6A11_RS09185	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
A6A11_RS09190	COG1414	Transcriptional regulator
A6A11_RS09195	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A6A11_RS09205	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A6A11_RS09210	COG3850	Histidine kinase
A6A11_RS09215	COG3062	negative regulation of establishment of protein localization
A6A11_RS09220	COG0243	molybdopterin cofactor binding
A6A11_RS09225	COG0437	4 iron, 4 sulfur cluster binding
A6A11_RS09230	COG0348	domain, Protein
A6A11_RS09235	COG3043	anaerobic respiration
A6A11_RS09240	COG3005	denitrification pathway
A6A11_RS09250	COG1982	Orn Lys Arg decarboxylase major
A6A11_RS09255	COG0531	amino acid
A6A11_RS09285	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A6A11_RS09290	COG1739	Uncharacterized protein family UPF0029
A6A11_RS09305	COG1040	competence protein
A6A11_RS09315	COG2814	Major facilitator Superfamily
A6A11_RS09320	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A6A11_RS09335	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A6A11_RS09355	COG3085	chromosome segregation
A6A11_RS09360	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A6A11_RS09365	COG3084	Protein conserved in bacteria
A6A11_RS09370	COG0746	molybdenum cofactor guanylyltransferase activity
A6A11_RS09375	COG1114	Component of the transport system for branched-chain amino acids
A6A11_RS09380	COG2183	response to ionizing radiation
A6A11_RS09390	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A6A11_RS09395	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A6A11_RS09400	COG0254	rRNA binding
A6A11_RS09405	COG5039	Polysaccharide pyruvyl transferase
A6A11_RS09415	COG3306	glycosyltransferase involved in LPS biosynthesis
A6A11_RS09425	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A6A11_RS09435	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A6A11_RS09445	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A6A11_RS09470	COG1640	4-alpha-glucanotransferase
A6A11_RS09475	COG0058	SHG alpha-glucan phosphorylase activity
A6A11_RS09480	COG2909	trisaccharide binding
A6A11_RS09485	COG3833	ABC-type maltose transport systems, permease component
A6A11_RS09490	COG1175	transmembrane transport
A6A11_RS09495	COG2182	Extracellular solute-binding protein
A6A11_RS09500	COG3842	ATPase activity
A6A11_RS09505	COG4580	involved in the transport of maltose and maltodextrins
A6A11_RS09515	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A6A11_RS09520	COG1854	S-ribosylhomocysteine lyase activity
A6A11_RS09525	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
A6A11_RS09535	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A6A11_RS09540	COG1349	DNA-binding transcription factor activity
A6A11_RS09550	COG3068	Protein conserved in bacteria
A6A11_RS09555	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
A6A11_RS09560	COG2816	NAD+ diphosphatase activity
A6A11_RS09590	COG2137	regulation of response to DNA damage stimulus
A6A11_RS09605	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
A6A11_RS09610	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A6A11_RS09615	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
A6A11_RS09625	COG1045	serine acetyltransferase
A6A11_RS09630	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A6A11_RS09640	COG3078	GTPase activator activity
A6A11_RS09650	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A6A11_RS09655	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A6A11_RS09660	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
A6A11_RS09670	COG0589	response to stress
A6A11_RS09675	COG3956	TIGRFAM MazG family protein
A6A11_RS09685	COG0758	DNA mediated transformation
A6A11_RS09695	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
A6A11_RS09710	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
A6A11_RS09715	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
A6A11_RS09720	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A6A11_RS09725	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
A6A11_RS09745	COG0051	transcription antitermination factor activity, RNA binding
A6A11_RS09750	COG0038	chloride channel
A6A11_RS09760	COG2841	Protein conserved in bacteria
A6A11_RS09770	COG1285	pathogenesis
A6A11_RS09780	COG3630	sodium ion export across plasma membrane
A6A11_RS09785	COG0511	ligase activity, forming carbon-carbon bonds
A6A11_RS09785	COG5016	pyruvate
A6A11_RS09795	COG1278	Cold shock
A6A11_RS09800	COG4988	ABC transporter
A6A11_RS09805	COG1132	(ABC) transporter
A6A11_RS09810	COG0859	PFAM glycosyl transferase family 9
A6A11_RS09815	COG0859	PFAM glycosyl transferase family 9
A6A11_RS09820	COG3307	-O-antigen
A6A11_RS09825	COG1278	Cold shock