locus-tag	class	description
MVA48_RS00025	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MVA48_RS00030	COG4221	oxidoreductase activity
MVA48_RS00035	COG0674	pyruvate-flavodoxin oxidoreductase activity
MVA48_RS00035	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
MVA48_RS00040	COG1013	pyruvate-flavodoxin oxidoreductase activity
MVA48_RS00055	COG1028	Short-chain dehydrogenase reductase Sdr
MVA48_RS00060	COG0446	pyridine nucleotide-disulphide oxidoreductase
MVA48_RS00060	COG1902	pentaerythritol trinitrate reductase activity
MVA48_RS00065	COG2086	electron transfer activity
MVA48_RS00075	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
MVA48_RS00080	COG0183	Belongs to the thiolase family
MVA48_RS00085	COG1960	acyl-CoA dehydrogenase activity
MVA48_RS00130	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MVA48_RS00160	COG0435	Glutathione S-transferase
MVA48_RS00250	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
MVA48_RS00265	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MVA48_RS00460	COG3012	SEC-C Motif Domain Protein
MVA48_RS00510	COG4585	Histidine kinase
MVA48_RS00515	COG2197	response regulator
MVA48_RS00530	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MVA48_RS00545	COG4251	negative regulation of phosphorylation
MVA48_RS00575	COG1690	Belongs to the RtcB family
MVA48_RS00595	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
MVA48_RS00600	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
MVA48_RS00635	COG2409	Drug exporters of the RND superfamily
MVA48_RS00660	COG2197	response regulator
MVA48_RS00665	COG4585	Histidine kinase
MVA48_RS00720	COG3795	YCII-related domain
MVA48_RS00725	COG4941	Belongs to the sigma-70 factor family
MVA48_RS00770	COG3842	ATPase activity
MVA48_RS00780	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MVA48_RS00785	COG0463	Glycosyl transferase, family 2
MVA48_RS00830	COG2223	nitrite transmembrane transporter activity
MVA48_RS00840	COG1028	Short-chain dehydrogenase reductase Sdr
MVA48_RS00845	COG1012	belongs to the aldehyde dehydrogenase family
MVA48_RS00850	COG0174	glutamine synthetase
MVA48_RS00860	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
MVA48_RS00880	COG3290	protein histidine kinase activity
MVA48_RS00900	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
MVA48_RS00915	COG1012	belongs to the aldehyde dehydrogenase family
MVA48_RS00920	COG0473	3-isopropylmalate dehydrogenase activity
MVA48_RS00930	COG2186	Transcriptional regulator
MVA48_RS00955	COG4988	ABC transporter
MVA48_RS00960	COG1294	oxidase, subunit
MVA48_RS00965	COG1271	oxidase subunit
MVA48_RS00995	COG1937	Protein conserved in bacteria
MVA48_RS01035	COG2197	response regulator
MVA48_RS01040	COG4585	Histidine kinase
MVA48_RS01065	COG2226	methyltransferase
MVA48_RS01095	COG4946	Tricorn protease homolog
MVA48_RS01095	COG1506	peptidase
MVA48_RS01095	COG0823	Involved in the tonB-independent uptake of proteins
MVA48_RS01105	COG1321	iron dependent repressor
MVA48_RS01110	COG0123	including yeast histone deacetylase and acetoin utilization protein
MVA48_RS01125	COG1490	D-aminoacyl-tRNA deacylase activity
MVA48_RS01135	COG2239	Acts as a magnesium transporter
MVA48_RS01145	COG1403	HNH endonuclease
MVA48_RS01150	COG2197	response regulator
MVA48_RS01175	COG2313	pseudouridylate synthase activity
MVA48_RS01215	COG0483	inositol monophosphate 1-phosphatase activity
MVA48_RS01240	COG0756	dUTP diphosphatase activity
MVA48_RS01270	COG0569	domain protein
MVA48_RS01275	COG0531	amino acid
MVA48_RS01280	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MVA48_RS01300	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
MVA48_RS01310	COG1250	3-hydroxyacyl-CoA dehydrogenase
MVA48_RS01310	COG1024	Enoyl-CoA hydratase
MVA48_RS01315	COG0183	Belongs to the thiolase family
MVA48_RS01330	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
MVA48_RS01340	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
MVA48_RS01345	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
MVA48_RS01380	COG3253	May function as heme-dependent peroxidase
MVA48_RS01385	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MVA48_RS01395	COG1278	Cold shock
MVA48_RS01435	COG1793	dna ligase
MVA48_RS01460	COG0577	efflux transmembrane transporter activity
MVA48_RS01460	COG1136	(ABC) transporter
MVA48_RS01465	COG1136	(ABC) transporter
MVA48_RS01465	COG0577	efflux transmembrane transporter activity
MVA48_RS01495	COG0823	Involved in the tonB-independent uptake of proteins
MVA48_RS01495	COG1506	peptidase
MVA48_RS01495	COG4946	Tricorn protease homolog
MVA48_RS01510	COG1028	Short-chain dehydrogenase reductase Sdr
MVA48_RS01535	COG0154	amidase activity
MVA48_RS01555	COG0322	excinuclease ABC activity
MVA48_RS01560	COG1660	Displays ATPase and GTPase activities
MVA48_RS01570	COG1481	regulation of sporulation
MVA48_RS01575	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MVA48_RS01580	COG0126	phosphoglycerate kinase activity
MVA48_RS01585	COG0149	triose-phosphate isomerase activity
MVA48_RS01590	COG0747	negative chemotaxis
MVA48_RS01615	COG0363	glucosamine-6-phosphate deaminase activity
MVA48_RS01635	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
MVA48_RS01645	COG0109	protoheme IX farnesyltransferase activity
MVA48_RS01670	COG0719	Fe-S assembly protein
MVA48_RS01680	COG0396	ATPase activity
MVA48_RS01690	COG0822	iron-sulfur transferase activity
MVA48_RS01695	COG2151	metal-sulfur cluster biosynthetic enzyme
MVA48_RS01725	COG0488	(ABC) transporter
MVA48_RS01735	COG1024	Enoyl-CoA hydratase
MVA48_RS01735	COG1250	3-hydroxyacyl-CoA dehydrogenase
MVA48_RS01740	COG1132	(ABC) transporter
MVA48_RS01750	COG2897	thiosulfate sulfurtransferase activity
MVA48_RS01770	COG1028	Short-chain dehydrogenase reductase Sdr
MVA48_RS01775	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
MVA48_RS01780	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
MVA48_RS01790	COG0741	lytic transglycosylase activity
MVA48_RS01790	COG0791	NLP P60 protein
MVA48_RS01795	COG0714	Associated with various cellular activities
MVA48_RS01805	COG2304	oxidoreductase activity
MVA48_RS01825	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MVA48_RS01850	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
MVA48_RS01895	COG1366	Belongs to the anti-sigma-factor antagonist family
MVA48_RS01910	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
MVA48_RS01915	COG3285	dna ligase
MVA48_RS01915	COG1793	dna ligase
MVA48_RS01920	COG3285	dna ligase
MVA48_RS01920	COG1793	dna ligase
MVA48_RS01925	COG0788	formyltetrahydrofolate deformylase activity
MVA48_RS01930	COG2814	Major facilitator Superfamily
MVA48_RS01990	COG0628	permease
MVA48_RS02000	COG3766	membrane
MVA48_RS02025	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
MVA48_RS02025	COG4651	solute:proton antiporter activity
MVA48_RS02035	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
MVA48_RS02040	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
MVA48_RS02060	COG0438	transferase activity, transferring glycosyl groups
MVA48_RS02120	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MVA48_RS02130	COG0589	response to stress
MVA48_RS02150	COG2264	protein methyltransferase activity
MVA48_RS02195	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
MVA48_RS02200	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
MVA48_RS02220	COG1639	'signal transduction protein
MVA48_RS02225	COG1028	Short-chain dehydrogenase reductase Sdr
MVA48_RS02230	COG1960	acyl-CoA dehydrogenase activity
MVA48_RS02235	COG1960	acyl-CoA dehydrogenase activity
MVA48_RS02250	COG4585	Histidine kinase
MVA48_RS02255	COG2197	response regulator
MVA48_RS02270	COG3485	protocatechuate 3,4-dioxygenase
MVA48_RS02280	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
MVA48_RS02285	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MVA48_RS02290	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
MVA48_RS02310	COG1129	ABC transporter
MVA48_RS02315	COG1172	Belongs to the binding-protein-dependent transport system permease family
MVA48_RS02320	COG1879	ABC-type sugar transport system periplasmic component
MVA48_RS02335	COG0346	lactoylglutathione lyase activity
MVA48_RS02340	COG4221	oxidoreductase activity
MVA48_RS02360	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MVA48_RS02410	COG0436	Aminotransferase
MVA48_RS02420	COG1126	abc transporter atp-binding protein
MVA48_RS02435	COG1012	belongs to the aldehyde dehydrogenase family
MVA48_RS02445	COG1228	amidohydrolase
MVA48_RS02450	COG2188	Transcriptional regulator
MVA48_RS02525	COG0477	Major facilitator Superfamily
MVA48_RS02535	COG0166	Belongs to the GPI family
MVA48_RS02570	COG2172	sigma factor antagonist activity
MVA48_RS02605	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
MVA48_RS02610	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
MVA48_RS02615	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
MVA48_RS02635	COG1414	Transcriptional regulator
MVA48_RS02640	COG0402	S-adenosylhomocysteine deaminase activity
MVA48_RS02660	COG3485	protocatechuate 3,4-dioxygenase
MVA48_RS02670	COG1278	Cold shock
MVA48_RS02675	COG3963	phosphatidate phosphatase activity
MVA48_RS02690	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MVA48_RS02690	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MVA48_RS02700	COG4702	Belongs to the UPF0303 family
MVA48_RS02705	COG1404	Belongs to the peptidase S8 family
MVA48_RS02760	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MVA48_RS02765	COG2151	metal-sulfur cluster biosynthetic enzyme
MVA48_RS02770	COG3396	Phenylacetate-CoA oxygenase
MVA48_RS02775	COG3460	Phenylacetate-CoA oxygenase
MVA48_RS02780	COG3396	Phenylacetate-CoA oxygenase
MVA48_RS02790	COG3663	DNA glycosylase
MVA48_RS02810	COG1846	Transcriptional regulator
MVA48_RS02815	COG1556	Lactate utilization protein
MVA48_RS02820	COG1139	Iron-sulfur cluster binding protein
MVA48_RS02825	COG0247	lactate metabolic process
MVA48_RS02830	COG0179	Fumarylacetoacetate (FAA) hydrolase
MVA48_RS02840	COG1063	alcohol dehydrogenase
MVA48_RS02860	COG2267	carboxylic ester hydrolase activity
MVA48_RS02870	COG3185	4-Hydroxyphenylpyruvate dioxygenase
MVA48_RS02885	COG0446	pyridine nucleotide-disulphide oxidoreductase
MVA48_RS02890	COG3481	metal-dependent phosphohydrolase, HD sub domain
MVA48_RS02895	COG1414	Transcriptional regulator
MVA48_RS02905	COG0574	Belongs to the PEP-utilizing enzyme family
MVA48_RS02905	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MVA48_RS02920	COG0574	Belongs to the PEP-utilizing enzyme family
MVA48_RS02920	COG3848	Pyruvate phosphate dikinase
MVA48_RS02955	COG0589	response to stress
MVA48_RS02980	COG1752	Esterase of the alpha-beta hydrolase superfamily
MVA48_RS02995	COG0579	oxidoreductase
MVA48_RS03000	COG2267	carboxylic ester hydrolase activity
MVA48_RS03005	COG2072	flavoprotein involved in K transport
MVA48_RS03015	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MVA48_RS03055	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MVA48_RS03060	COG3483	tryptophan 2,3-dioxygenase activity
MVA48_RS03075	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MVA48_RS03075	COG1017	nitric oxide dioxygenase activity
MVA48_RS03080	COG3012	SEC-C Motif Domain Protein
MVA48_RS03090	COG1793	dna ligase
MVA48_RS03100	COG2755	lipolytic protein G-D-S-L family
MVA48_RS03135	COG0657	acetylesterase activity
MVA48_RS03140	COG2409	Drug exporters of the RND superfamily
MVA48_RS03145	COG1309	transcriptional regulator
MVA48_RS03180	COG0318	PFAM AMP-dependent synthetase and ligase
MVA48_RS03190	COG4941	Belongs to the sigma-70 factor family
MVA48_RS03205	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
MVA48_RS03215	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
MVA48_RS03235	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
MVA48_RS03245	COG0604	alcohol dehydrogenase
MVA48_RS03275	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
MVA48_RS03300	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MVA48_RS03315	COG2066	Belongs to the glutaminase family
MVA48_RS03350	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MVA48_RS03355	COG1609	Transcriptional regulator
MVA48_RS03480	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
MVA48_RS03500	COG3415	Transposase
MVA48_RS03500	COG2801	Transposase and inactivated derivatives
MVA48_RS03510	COG0351	phosphomethylpyrimidine kinase
MVA48_RS03515	COG0352	thiamine-phosphate diphosphorylase activity
MVA48_RS03520	COG2022	thiamine diphosphate biosynthetic process
MVA48_RS03530	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MVA48_RS03530	COG2022	thiamine diphosphate biosynthetic process
MVA48_RS03535	COG0352	thiamine-phosphate diphosphorylase activity
MVA48_RS03555	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MVA48_RS03600	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MVA48_RS03605	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MVA48_RS03610	COG0667	Aldo Keto reductase
MVA48_RS03615	COG1968	undecaprenyl-diphosphatase activity
MVA48_RS03650	COG0232	Belongs to the dGTPase family. Type 2 subfamily
MVA48_RS03665	COG2124	cytochrome p450
MVA48_RS03705	COG1222	aaa ATPase
MVA48_RS03725	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
MVA48_RS03730	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
MVA48_RS03735	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
MVA48_RS03760	COG2385	sporulation resulting in formation of a cellular spore
MVA48_RS03770	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MVA48_RS03790	COG4581	dead DEAH box helicase
MVA48_RS03805	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MVA48_RS03815	COG1522	sequence-specific DNA binding
MVA48_RS03850	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MVA48_RS03865	COG0604	alcohol dehydrogenase
MVA48_RS03880	COG5012	cobalamin binding
MVA48_RS03885	COG1607	acyl-coa hydrolase
MVA48_RS03895	COG0815	Transfers the fatty acyl group on membrane lipoproteins
MVA48_RS03900	COG1216	Glycosyl transferase, family 2
MVA48_RS03905	COG3030	protein affecting phage T7 exclusion by the F plasmid
MVA48_RS03915	COG1435	thymidine kinase activity
MVA48_RS03955	COG1335	isochorismatase
MVA48_RS03975	COG3214	Protein conserved in bacteria
MVA48_RS03985	COG1554	hydrolase, family 65, central catalytic
MVA48_RS04025	COG1072	(Pantothenic acid kinase))
MVA48_RS04035	COG2318	DinB family
MVA48_RS04040	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MVA48_RS04040	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MVA48_RS04070	COG0509	glycine decarboxylation via glycine cleavage system
MVA48_RS04110	COG0579	oxidoreductase
MVA48_RS04135	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MVA48_RS04140	COG4948	Mandelate Racemase Muconate Lactonizing
MVA48_RS04150	COG0439	Biotin carboxylase
MVA48_RS04160	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
MVA48_RS04165	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
MVA48_RS04200	COG1175	transmembrane transport
MVA48_RS04205	COG0395	ABC-type sugar transport system, permease component
MVA48_RS04220	COG2111	Na H antiporter
MVA48_RS04220	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MVA48_RS04225	COG1006	Multisubunit Na H antiporter MnhC subunit
MVA48_RS04230	COG0651	ATP synthesis coupled electron transport
MVA48_RS04235	COG1863	multisubunit Na H antiporter MnhE subunit
MVA48_RS04255	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
MVA48_RS04260	COG3387	PFAM Glycoside hydrolase 15-related
MVA48_RS04285	COG1129	ABC transporter
MVA48_RS04295	COG1172	Belongs to the binding-protein-dependent transport system permease family
MVA48_RS04310	COG1028	Short-chain dehydrogenase reductase Sdr
MVA48_RS04325	COG1960	acyl-CoA dehydrogenase activity
MVA48_RS04340	COG3959	Transketolase, thiamine diphosphate binding domain
MVA48_RS04345	COG3958	Transketolase
MVA48_RS04350	COG0371	Dehydrogenase
MVA48_RS04380	COG1012	belongs to the aldehyde dehydrogenase family
MVA48_RS04390	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MVA48_RS04400	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
MVA48_RS04405	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
MVA48_RS04460	COG1160	GTP binding
MVA48_RS04465	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
MVA48_RS04470	COG4401	Chorismate mutase type I
MVA48_RS04485	COG1609	Transcriptional regulator
MVA48_RS04505	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
MVA48_RS04510	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
MVA48_RS04540	COG0686	Belongs to the AlaDH PNT family
MVA48_RS04550	COG0494	nUDIX hydrolase
MVA48_RS04555	COG0504	CTP synthase activity
MVA48_RS04565	COG0438	transferase activity, transferring glycosyl groups
MVA48_RS04595	COG1309	transcriptional regulator
MVA48_RS04615	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
MVA48_RS04635	COG0647	UMP catabolic process
MVA48_RS04675	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
MVA48_RS04680	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
MVA48_RS04685	COG2094	Belongs to the DNA glycosylase MPG family
MVA48_RS04690	COG0165	Argininosuccinate lyase
MVA48_RS04695	COG1438	arginine binding
MVA48_RS04700	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
MVA48_RS04710	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
MVA48_RS04715	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
MVA48_RS04720	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
MVA48_RS04725	COG0300	oxidoreductase activity
MVA48_RS04730	COG0072	phenylalanine-tRNA ligase activity
MVA48_RS04730	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MVA48_RS04735	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
MVA48_RS04740	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
MVA48_RS04750	COG1522	sequence-specific DNA binding
MVA48_RS04755	COG0531	amino acid
MVA48_RS04760	COG1304	FMN binding
MVA48_RS04785	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MVA48_RS04790	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
MVA48_RS04795	COG0291	Belongs to the bacterial ribosomal protein bL35 family
MVA48_RS04800	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
MVA48_RS04810	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MVA48_RS04830	COG2223	nitrite transmembrane transporter activity
MVA48_RS04855	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MVA48_RS04860	COG0243	molybdopterin cofactor binding
MVA48_RS04870	COG3795	YCII-related domain
MVA48_RS04875	COG4941	Belongs to the sigma-70 factor family
MVA48_RS04880	COG0137	argininosuccinate synthase activity
MVA48_RS04885	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
MVA48_RS04895	COG2040	homocysteine
MVA48_RS04900	COG1028	Short-chain dehydrogenase reductase Sdr
MVA48_RS04960	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MVA48_RS04970	COG1742	UPF0060 membrane protein
MVA48_RS05030	COG2267	carboxylic ester hydrolase activity
MVA48_RS05040	COG0402	S-adenosylhomocysteine deaminase activity
MVA48_RS05065	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
MVA48_RS05070	COG0140	phosphoribosyl-ATP diphosphatase activity
MVA48_RS05075	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
MVA48_RS05080	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MVA48_RS05080	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MVA48_RS05130	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
MVA48_RS05140	COG0242	peptide deformylase activity
MVA48_RS05150	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
MVA48_RS05160	COG1758	RNA polymerase activity
MVA48_RS05165	COG0194	GDP metabolic process
MVA48_RS05190	COG0284	orotidine-5'-phosphate decarboxylase activity
MVA48_RS05195	COG0167	dihydroorotate dehydrogenase activity
MVA48_RS05210	COG0505	Belongs to the CarA family
MVA48_RS05215	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
MVA48_RS05220	COG0540	Belongs to the ATCase OTCase family
MVA48_RS05235	COG1131	(ABC) transporter
MVA48_RS05255	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MVA48_RS05260	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
MVA48_RS05265	COG0006	proline dipeptidase activity
MVA48_RS05270	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
MVA48_RS05275	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
MVA48_RS05280	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
MVA48_RS05285	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
MVA48_RS05295	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MVA48_RS05310	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MVA48_RS05330	COG0667	Aldo Keto reductase
MVA48_RS05340	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
MVA48_RS05355	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
MVA48_RS05365	COG0667	Aldo Keto reductase
MVA48_RS05370	COG0124	histidyl-tRNA synthetase
MVA48_RS05375	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MVA48_RS05385	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MVA48_RS05390	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MVA48_RS05400	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MVA48_RS05410	COG2255	four-way junction helicase activity
MVA48_RS05415	COG0632	four-way junction helicase activity
MVA48_RS05420	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
MVA48_RS05425	COG0217	transcriptional regulatory protein
MVA48_RS05445	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
MVA48_RS05455	COG0438	transferase activity, transferring glycosyl groups
MVA48_RS05475	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MVA48_RS05530	COG1595	DNA-templated transcription, initiation
MVA48_RS05570	COG0237	dephospho-CoA kinase activity
MVA48_RS05580	COG0539	negative regulation of cytoplasmic translation
MVA48_RS05585	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MVA48_RS05610	COG1172	Belongs to the binding-protein-dependent transport system permease family
MVA48_RS05640	COG0076	glutamate decarboxylase activity
MVA48_RS05645	COG1946	Acyl-CoA thioesterase
MVA48_RS05660	COG0069	glutamate synthase activity
MVA48_RS05660	COG0067	glutamate synthase
MVA48_RS05660	COG0070	glutamate synthase
MVA48_RS05665	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
MVA48_RS05670	COG0159	tryptophan synthase activity
MVA48_RS05675	COG0133	tryptophan synthase activity
MVA48_RS05690	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MVA48_RS05695	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
MVA48_RS05710	COG3573	Dehydrogenase
MVA48_RS05715	COG3573	Dehydrogenase
MVA48_RS05725	COG1132	(ABC) transporter
MVA48_RS05730	COG1132	(ABC) transporter
MVA48_RS05740	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
MVA48_RS05745	COG1129	ABC transporter
MVA48_RS05755	COG1172	Belongs to the binding-protein-dependent transport system permease family
MVA48_RS05775	COG1940	carbohydrate kinase activity
MVA48_RS05775	COG1846	Transcriptional regulator
MVA48_RS05780	COG0107	imidazoleglycerol-phosphate synthase activity
MVA48_RS05790	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
MVA48_RS05800	COG1028	Short-chain dehydrogenase reductase Sdr
MVA48_RS05815	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
MVA48_RS05825	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
MVA48_RS05840	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
MVA48_RS05855	COG0131	Imidazoleglycerol-phosphate dehydratase
MVA48_RS05860	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MVA48_RS05865	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
MVA48_RS05880	COG0587	DNA-directed DNA polymerase activity
MVA48_RS05900	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
MVA48_RS05920	COG3345	alpha-galactosidase
MVA48_RS05925	COG0395	ABC-type sugar transport system, permease component
MVA48_RS05930	COG1175	transmembrane transport
MVA48_RS05940	COG3842	ATPase activity
MVA48_RS05955	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
MVA48_RS05995	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
MVA48_RS06005	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
MVA48_RS06010	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
MVA48_RS06025	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
MVA48_RS06030	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MVA48_RS06040	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
MVA48_RS06045	COG0768	penicillin binding
MVA48_RS06055	COG0275	rRNA processing
MVA48_RS06060	COG2001	Belongs to the MraZ family
MVA48_RS06065	COG0714	Associated with various cellular activities
MVA48_RS06085	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MVA48_RS06100	COG2850	peptidyl-arginine hydroxylation
MVA48_RS06135	COG0587	DNA-directed DNA polymerase activity
MVA48_RS06140	COG0587	DNA-directed DNA polymerase activity
MVA48_RS06180	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MVA48_RS06185	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MVA48_RS06260	COG0142	geranyltranstransferase activity
MVA48_RS06295	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MVA48_RS06300	COG0515	serine threonine protein kinase
MVA48_RS06300	COG2815	serine threonine protein kinase
MVA48_RS06305	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
MVA48_RS06320	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
MVA48_RS06345	COG2261	transglycosylase associated protein
MVA48_RS06380	COG2072	flavoprotein involved in K transport
MVA48_RS06390	COG2267	carboxylic ester hydrolase activity
MVA48_RS06425	COG1940	carbohydrate kinase activity
MVA48_RS06445	COG1022	Amp-dependent synthetase and ligase
MVA48_RS06450	COG0438	transferase activity, transferring glycosyl groups
MVA48_RS06455	COG0501	Belongs to the peptidase M48B family
MVA48_RS06470	COG1876	peptidase activity
MVA48_RS06485	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MVA48_RS06495	COG1845	cytochrome c oxidase, subunit III
MVA48_RS06500	COG2010	Cytochrome c
MVA48_RS06510	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
MVA48_RS06515	COG2076	Multidrug Resistance protein
MVA48_RS06525	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
MVA48_RS06560	COG0667	Aldo Keto reductase
MVA48_RS06585	COG1295	ribonuclease BN
MVA48_RS06590	COG0404	The glycine cleavage system catalyzes the degradation of glycine
MVA48_RS06595	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
MVA48_RS06605	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MVA48_RS06625	COG0515	serine threonine protein kinase
MVA48_RS06625	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MVA48_RS06630	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
MVA48_RS06650	COG0321	lipoyl(octanoyl) transferase activity
MVA48_RS06655	COG0495	leucyl-tRNA aminoacylation
MVA48_RS06675	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
MVA48_RS06720	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
MVA48_RS06760	COG4221	oxidoreductase activity
MVA48_RS06780	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
MVA48_RS06790	COG0174	glutamine synthetase
MVA48_RS06815	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MVA48_RS06815	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
MVA48_RS06820	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
MVA48_RS06835	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MVA48_RS06875	COG1834	amidinotransferase
MVA48_RS06925	COG2894	cell division
MVA48_RS06950	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
MVA48_RS06965	COG0673	inositol 2-dehydrogenase activity
MVA48_RS07000	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
MVA48_RS07050	COG1966	Carbon starvation protein
MVA48_RS07060	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
MVA48_RS07065	COG1289	transmembrane transporter activity
MVA48_RS07090	COG0596	Alpha beta hydrolase
MVA48_RS07090	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MVA48_RS07090	COG2226	methyltransferase
MVA48_RS07120	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
MVA48_RS07130	COG1473	amidohydrolase
MVA48_RS07145	COG0671	phosphoesterase, PA-phosphatase related
MVA48_RS07160	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MVA48_RS07205	COG0739	heme binding
MVA48_RS07215	COG4974	Belongs to the 'phage' integrase family
MVA48_RS07275	COG1454	alcohol dehydrogenase
MVA48_RS07285	COG0515	serine threonine protein kinase
MVA48_RS07285	COG2815	serine threonine protein kinase
MVA48_RS07335	COG1609	Transcriptional regulator
MVA48_RS07340	COG1609	Transcriptional regulator
MVA48_RS07365	COG1175	transmembrane transport
MVA48_RS07370	COG0395	ABC-type sugar transport system, permease component
MVA48_RS07390	COG3634	alkyl hydroperoxide reductase activity
MVA48_RS07395	COG1396	sequence-specific DNA binding
MVA48_RS07445	COG3328	transposase activity
MVA48_RS07470	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MVA48_RS07480	COG3971	2-oxopent-4-enoate hydratase activity
MVA48_RS07500	COG0559	Belongs to the binding-protein-dependent transport system permease family
MVA48_RS07520	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
MVA48_RS07525	COG1335	isochorismatase
MVA48_RS07560	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MVA48_RS07565	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
MVA48_RS07590	COG2843	Capsule synthesis protein
MVA48_RS07620	COG2072	flavoprotein involved in K transport
MVA48_RS07640	COG1960	acyl-CoA dehydrogenase activity
MVA48_RS07655	COG2072	flavoprotein involved in K transport
MVA48_RS07675	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MVA48_RS07680	COG1024	Enoyl-CoA hydratase
MVA48_RS07685	COG1309	transcriptional regulator
MVA48_RS07695	COG0318	PFAM AMP-dependent synthetase and ligase
MVA48_RS07700	COG1960	acyl-CoA dehydrogenase activity
MVA48_RS07705	COG1960	acyl-CoA dehydrogenase activity
MVA48_RS07710	COG1024	Enoyl-CoA hydratase
MVA48_RS07820	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MVA48_RS07825	COG3384	dioxygenase
MVA48_RS07835	COG2259	Doxx family
MVA48_RS07845	COG0346	lactoylglutathione lyase activity
MVA48_RS07885	COG2197	response regulator
MVA48_RS07890	COG4585	Histidine kinase
MVA48_RS07900	COG0574	Belongs to the PEP-utilizing enzyme family
MVA48_RS07900	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MVA48_RS07915	COG0423	glycine-tRNA ligase activity
MVA48_RS07940	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MVA48_RS07955	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
MVA48_RS07995	COG0537	adenosine 5'-monophosphoramidase activity
MVA48_RS08005	COG0484	heat shock protein binding
MVA48_RS08010	COG1420	regulation of RNA biosynthetic process
MVA48_RS08035	COG1024	Enoyl-CoA hydratase
MVA48_RS08045	COG1404	Belongs to the peptidase S8 family
MVA48_RS08055	COG1921	L-seryl-tRNASec selenium transferase activity
MVA48_RS08065	COG2378	regulation of single-species biofilm formation
MVA48_RS08070	COG0709	Synthesizes selenophosphate from selenide and ATP
MVA48_RS08080	COG0604	alcohol dehydrogenase
MVA48_RS08115	COG0477	Major facilitator Superfamily
MVA48_RS08130	COG2258	MOSC domain
MVA48_RS08135	COG0481	GTPase activity
MVA48_RS08160	COG1307	EDD domain protein, DegV family
MVA48_RS08165	COG0406	alpha-ribazole phosphatase activity
MVA48_RS08170	COG0799	negative regulation of ribosome biogenesis
MVA48_RS08175	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
MVA48_RS08180	COG0542	response to heat
MVA48_RS08185	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
MVA48_RS08195	COG1121	(ABC) transporter
MVA48_RS08200	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MVA48_RS08230	COG0227	Belongs to the bacterial ribosomal protein bL28 family
MVA48_RS08235	COG0267	Belongs to the bacterial ribosomal protein bL33 family
MVA48_RS08240	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
MVA48_RS08245	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
MVA48_RS08275	COG0701	Predicted permease
MVA48_RS08300	COG0242	peptide deformylase activity
MVA48_RS08310	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
MVA48_RS08320	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MVA48_RS08325	COG0211	Belongs to the bacterial ribosomal protein bL27 family
MVA48_RS08330	COG0261	This protein binds to 23S rRNA in the presence of protein L20
MVA48_RS08335	COG1530	ribonuclease E activity
MVA48_RS08360	COG0105	UTP biosynthetic process
MVA48_RS08375	COG0285	dihydrofolate synthase activity
MVA48_RS08380	COG3304	Inner membrane component domain
MVA48_RS08385	COG0525	valine-tRNA ligase activity
MVA48_RS08400	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
MVA48_RS08405	COG0740	serine-type endopeptidase activity
MVA48_RS08415	COG0544	peptidyl-prolyl cis-trans isomerase activity
MVA48_RS08430	COG1012	belongs to the aldehyde dehydrogenase family
MVA48_RS08440	COG0346	lactoylglutathione lyase activity
MVA48_RS08450	COG1079	Belongs to the binding-protein-dependent transport system permease family
MVA48_RS08455	COG4603	Belongs to the binding-protein-dependent transport system permease family
MVA48_RS08460	COG3845	ABC transporter
MVA48_RS08465	COG1744	ABC transporter substrate-binding protein PnrA-like
MVA48_RS08470	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MVA48_RS08475	COG2186	Transcriptional regulator
MVA48_RS08500	COG4565	transcriptional regulatory protein
MVA48_RS08505	COG3290	protein histidine kinase activity
MVA48_RS08510	COG1301	dicarboxylic acid transport
MVA48_RS08520	COG0477	Major facilitator Superfamily
MVA48_RS08545	COG2337	Toxic component of a toxin-antitoxin (TA) module
MVA48_RS08555	COG2197	response regulator
MVA48_RS08565	COG4585	Histidine kinase
MVA48_RS08620	COG2197	response regulator
MVA48_RS08625	COG4552	Acetyltransferase involved in intracellular survival and related
MVA48_RS08655	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
MVA48_RS08700	COG1505	serine-type exopeptidase activity
MVA48_RS08705	COG0668	transmembrane transport
MVA48_RS08715	COG2346	COG2346, Truncated hemoglobins
MVA48_RS08720	COG0366	Alpha amylase catalytic
MVA48_RS08725	COG1268	BioY protein
MVA48_RS08730	COG1122	ATPase activity
MVA48_RS08735	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MVA48_RS08795	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
MVA48_RS08800	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
MVA48_RS08805	COG0157	Belongs to the NadC ModD family
MVA48_RS08825	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MVA48_RS08840	COG1305	Transglutaminase-like
MVA48_RS08845	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MVA48_RS08870	COG1131	(ABC) transporter
MVA48_RS08880	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
MVA48_RS08905	COG2116	formate transmembrane transporter activity
MVA48_RS08915	COG1929	Belongs to the glycerate kinase type-1 family
MVA48_RS08920	COG1349	DNA-binding transcription factor activity
MVA48_RS08925	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
MVA48_RS08930	COG3395	kinase activity
MVA48_RS08935	COG2610	gluconate transmembrane transporter activity
MVA48_RS08950	COG1960	acyl-CoA dehydrogenase activity
MVA48_RS08960	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
MVA48_RS08965	COG1309	transcriptional regulator
MVA48_RS08980	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
MVA48_RS08990	COG0778	Nitroreductase
MVA48_RS09000	COG0545	Peptidyl-prolyl cis-trans isomerase
MVA48_RS09045	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
MVA48_RS09050	COG1492	cobalamin metabolic process
MVA48_RS09055	COG1492	cobalamin metabolic process
MVA48_RS09070	COG1797	cobyrinic acid a,c-diamide synthase activity
MVA48_RS09075	COG0310	cobalt ion transport
MVA48_RS09105	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MVA48_RS09105	COG1648	precorrin-2 dehydrogenase activity
MVA48_RS09115	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MVA48_RS09115	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MVA48_RS09140	COG2072	flavoprotein involved in K transport
MVA48_RS09145	COG1960	acyl-CoA dehydrogenase activity
MVA48_RS09155	COG1024	Enoyl-CoA hydratase
MVA48_RS09155	COG1250	3-hydroxyacyl-CoA dehydrogenase
MVA48_RS09160	COG0183	Belongs to the thiolase family
MVA48_RS09165	COG1960	acyl-CoA dehydrogenase activity
MVA48_RS09185	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
MVA48_RS09200	COG1376	ErfK ybiS ycfS ynhG family protein
MVA48_RS09240	COG2072	flavoprotein involved in K transport
MVA48_RS09285	COG1012	belongs to the aldehyde dehydrogenase family
MVA48_RS09290	COG0506	proline dehydrogenase activity
MVA48_RS09310	COG1028	Short-chain dehydrogenase reductase Sdr
MVA48_RS09320	COG1404	Belongs to the peptidase S8 family
MVA48_RS09335	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
MVA48_RS09340	COG0596	Alpha beta hydrolase
MVA48_RS09345	COG0477	Major facilitator Superfamily
MVA48_RS09380	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MVA48_RS09385	COG1960	acyl-CoA dehydrogenase activity
MVA48_RS09395	COG0667	Aldo Keto reductase
MVA48_RS09405	COG3300	MHYT domain
MVA48_RS09405	COG5001	Diguanylate cyclase
MVA48_RS09435	COG0019	diaminopimelate decarboxylase activity
MVA48_RS09455	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
MVA48_RS09475	COG1793	dna ligase
MVA48_RS09475	COG3285	dna ligase
MVA48_RS09480	COG1234	tRNA 3'-trailer cleavage
MVA48_RS09485	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
MVA48_RS09515	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
MVA48_RS09525	COG1335	isochorismatase
MVA48_RS09530	COG3830	Belongs to the UPF0237 family
MVA48_RS09530	COG0560	Phosphoserine phosphatase
MVA48_RS09560	COG0739	heme binding
MVA48_RS09585	COG0488	(ABC) transporter
MVA48_RS09630	COG1191	sigma factor activity
MVA48_RS09640	COG0754	glutathionylspermidine amidase activity
MVA48_RS09660	COG1024	Enoyl-CoA hydratase
MVA48_RS09680	COG0745	RESPONSE REGULATOR receiver
MVA48_RS09685	COG2205	protein histidine kinase activity
MVA48_RS09685	COG2202	Pas domain
MVA48_RS09720	COG0745	RESPONSE REGULATOR receiver
MVA48_RS09725	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
MVA48_RS09725	COG4106	trans-aconitate 2-methyltransferase activity
MVA48_RS09735	COG2193	ferroxidase activity
MVA48_RS09785	COG0515	serine threonine protein kinase
MVA48_RS09790	COG3265	gluconokinase activity
MVA48_RS09855	COG0745	RESPONSE REGULATOR receiver
MVA48_RS09890	COG1053	succinate dehydrogenase
MVA48_RS09915	COG1960	acyl-CoA dehydrogenase activity
MVA48_RS09920	COG2186	Transcriptional regulator
MVA48_RS09925	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MVA48_RS09940	COG0824	Thioesterase
MVA48_RS10025	COG0739	heme binding
MVA48_RS10030	COG0246	Mannitol dehydrogenase
MVA48_RS10035	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MVA48_RS10045	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MVA48_RS10090	COG0477	Major facilitator Superfamily
MVA48_RS10095	COG0730	response to heat
MVA48_RS10110	COG2826	transposase and inactivated derivatives, IS30 family
MVA48_RS10115	COG1217	gtp-binding protein TYPA
MVA48_RS10130	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MVA48_RS10135	COG2353	YceI-like domain
MVA48_RS10160	COG2197	response regulator
MVA48_RS10170	COG4585	Histidine kinase
MVA48_RS10175	COG2197	response regulator
MVA48_RS10180	COG2197	response regulator
MVA48_RS10185	COG4585	Histidine kinase
MVA48_RS10200	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
MVA48_RS10215	COG1131	(ABC) transporter
MVA48_RS10245	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
MVA48_RS10265	COG1752	Esterase of the alpha-beta hydrolase superfamily
MVA48_RS10300	COG0733	neurotransmitter:sodium symporter activity
MVA48_RS10330	COG5002	protein histidine kinase activity
MVA48_RS10330	COG2176	DNA-directed DNA polymerase activity
MVA48_RS10360	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MVA48_RS10365	COG1074	ATP-dependent DNA helicase activity
MVA48_RS10460	COG0363	glucosamine-6-phosphate deaminase activity
MVA48_RS10475	COG3328	transposase activity
MVA48_RS10520	COG0598	Magnesium transport protein CorA
MVA48_RS10560	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
MVA48_RS10565	COG2177	Part of the ABC transporter FtsEX involved in
MVA48_RS10570	COG2884	Cell division ATP-binding protein ftsE
MVA48_RS10575	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
MVA48_RS10590	COG1324	tolerance protein
MVA48_RS10670	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
MVA48_RS10710	COG0028	Belongs to the TPP enzyme family
MVA48_RS10730	COG3135	benzoate transporter
MVA48_RS10750	COG1024	Enoyl-CoA hydratase
MVA48_RS10790	COG2239	Acts as a magnesium transporter
MVA48_RS10825	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MVA48_RS10830	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MVA48_RS10840	COG1595	DNA-templated transcription, initiation
MVA48_RS10865	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
MVA48_RS10880	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MVA48_RS10885	COG1120	ATPase activity
MVA48_RS10905	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
MVA48_RS10915	COG2208	phosphoserine phosphatase activity
MVA48_RS10950	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
MVA48_RS10960	COG0519	Catalyzes the synthesis of GMP from XMP
MVA48_RS11005	COG1611	Belongs to the LOG family
MVA48_RS11025	COG2171	N-acyltransferase activity
MVA48_RS11040	COG4249	Peptidase C14 caspase catalytic subunit p20
MVA48_RS11040	COG2319	Wd-40 repeat
MVA48_RS11065	COG0456	acetyltransferase
MVA48_RS11075	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
MVA48_RS11085	COG4608	Belongs to the ABC transporter superfamily
MVA48_RS11105	COG4608	Belongs to the ABC transporter superfamily
MVA48_RS11110	COG0444	Belongs to the ABC transporter superfamily
MVA48_RS11115	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MVA48_RS11140	COG0494	nUDIX hydrolase
MVA48_RS11150	COG0529	Catalyzes the synthesis of activated sulfate
MVA48_RS11150	COG2046	Belongs to the sulfate adenylyltransferase family
MVA48_RS11165	COG0175	sulfate reduction
MVA48_RS11170	COG2154	pterin-4-alpha-carbinolamine dehydratase
MVA48_RS11190	COG1131	(ABC) transporter
MVA48_RS11195	COG2116	formate transmembrane transporter activity
MVA48_RS11210	COG1017	nitric oxide dioxygenase activity
MVA48_RS11210	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MVA48_RS11215	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
MVA48_RS11225	COG1053	succinate dehydrogenase
MVA48_RS11230	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
MVA48_RS11265	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
MVA48_RS11270	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MVA48_RS11315	COG0477	Major facilitator Superfamily
MVA48_RS11335	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
MVA48_RS11345	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
MVA48_RS11360	COG1595	DNA-templated transcription, initiation
MVA48_RS11380	COG0012	GTP binding
MVA48_RS11385	COG2197	response regulator
MVA48_RS11390	COG4585	Histidine kinase
MVA48_RS11415	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MVA48_RS11420	COG1322	Protein conserved in bacteria
MVA48_RS11425	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
MVA48_RS11435	COG1570	exodeoxyribonuclease VII activity
MVA48_RS11440	COG1722	exodeoxyribonuclease VII activity
MVA48_RS11475	COG0114	fumarate hydratase activity
MVA48_RS11520	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
MVA48_RS11525	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
MVA48_RS11530	COG1256	bacterial-type flagellum assembly
MVA48_RS11530	COG4786	Flagellar basal body rod
MVA48_RS11545	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
MVA48_RS11585	COG1677	Flagellar hook-basal body complex protein FliE
MVA48_RS11590	COG1766	The M ring may be actively involved in energy transduction
MVA48_RS11595	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
MVA48_RS11615	COG1196	nuclear chromosome segregation
MVA48_RS11615	COG0741	lytic transglycosylase activity
MVA48_RS11615	COG0739	heme binding
MVA48_RS11625	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
MVA48_RS11670	COG1776	CheC inhibitor of MCP methylation
MVA48_RS11670	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
MVA48_RS11680	COG1338	Plays a role in the flagellum-specific transport system
MVA48_RS11690	COG1684	flagellar biosynthetic protein fliR
MVA48_RS11700	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
MVA48_RS11730	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
MVA48_RS11765	COG0644	oxidoreductase
MVA48_RS11790	COG0745	RESPONSE REGULATOR receiver
MVA48_RS11795	COG5002	protein histidine kinase activity
MVA48_RS11820	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
MVA48_RS11840	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
MVA48_RS11845	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
MVA48_RS11865	COG2755	lipolytic protein G-D-S-L family
MVA48_RS11870	COG0183	Belongs to the thiolase family
MVA48_RS11885	COG1252	NADH dehydrogenase
MVA48_RS11915	COG0148	phosphopyruvate hydratase activity
MVA48_RS11935	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
MVA48_RS12015	COG0193	aminoacyl-tRNA hydrolase activity
MVA48_RS12030	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
MVA48_RS12035	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MVA48_RS12050	COG1309	transcriptional regulator
MVA48_RS12055	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
MVA48_RS12060	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
MVA48_RS12080	COG0084	hydrolase, TatD family'
MVA48_RS12085	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MVA48_RS12090	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MVA48_RS12115	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MVA48_RS12135	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MVA48_RS12145	COG1210	Utp--glucose-1-phosphate uridylyltransferase
MVA48_RS12150	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
MVA48_RS12185	COG1970	mechanosensitive ion channel activity
MVA48_RS12215	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
MVA48_RS12220	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
MVA48_RS12230	COG1073	alpha beta
MVA48_RS12230	COG2226	methyltransferase
MVA48_RS12245	COG1595	DNA-templated transcription, initiation
MVA48_RS12270	COG0415	Belongs to the DNA photolyase family
MVA48_RS12295	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
MVA48_RS12305	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MVA48_RS12315	COG4152	abc transporter atp-binding protein
MVA48_RS12325	COG1573	uracil-dna glycosylase
MVA48_RS12330	COG0477	Major facilitator Superfamily
MVA48_RS12340	COG0259	pyridoxamine-phosphate oxidase activity
MVA48_RS12350	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
MVA48_RS12355	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
MVA48_RS12365	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
MVA48_RS12365	COG2308	Evidence 4 Homologs of previously reported genes of
MVA48_RS12370	COG0823	Involved in the tonB-independent uptake of proteins
MVA48_RS12385	COG1132	(ABC) transporter
MVA48_RS12395	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MVA48_RS12400	COG1131	(ABC) transporter
MVA48_RS12420	COG0667	Aldo Keto reductase
MVA48_RS12435	COG2814	Major facilitator Superfamily
MVA48_RS12445	COG2252	PERMEase
MVA48_RS12460	COG2814	Major facilitator Superfamily
MVA48_RS12510	COG1061	Type III restriction enzyme res subunit
MVA48_RS12525	COG1061	Type III restriction enzyme res subunit
MVA48_RS12530	COG1672	PFAM Archaeal ATPase
MVA48_RS12530	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
MVA48_RS12545	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MVA48_RS12575	COG0459	protein refolding
MVA48_RS12630	COG2239	Acts as a magnesium transporter
MVA48_RS12640	COG3360	Dodecin
MVA48_RS12680	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MVA48_RS12700	COG2733	membrane
MVA48_RS12710	COG0215	cysteine-tRNA ligase activity
MVA48_RS12715	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
MVA48_RS12720	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
MVA48_RS12725	COG1329	Transcriptional regulator
MVA48_RS12745	COG2847	Copper chaperone PCu(A)C
MVA48_RS12755	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
MVA48_RS12785	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
MVA48_RS12790	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
MVA48_RS12795	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
MVA48_RS12800	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
MVA48_RS12835	COG1174	glycine betaine transport
MVA48_RS12840	COG1174	glycine betaine transport
MVA48_RS12845	COG0517	IMP dehydrogenase activity
MVA48_RS12845	COG1125	glycine betaine transport
MVA48_RS12860	COG4941	Belongs to the sigma-70 factor family
MVA48_RS12875	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
MVA48_RS12890	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MVA48_RS12900	COG0037	tRNA processing
MVA48_RS12910	COG2027	D-alanyl-D-alanine carboxypeptidase
MVA48_RS12915	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
MVA48_RS12925	COG0747	negative chemotaxis
MVA48_RS12935	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
MVA48_RS12940	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
MVA48_RS12945	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
MVA48_RS12980	COG1394	ATPase activity, coupled to movement of substances
MVA48_RS12990	COG1269	ATP hydrolysis coupled proton transport
MVA48_RS13010	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
MVA48_RS13045	COG0549	Belongs to the carbamate kinase family
MVA48_RS13050	COG1335	isochorismatase
MVA48_RS13070	COG1863	multisubunit Na H antiporter MnhE subunit
MVA48_RS13075	COG0651	ATP synthesis coupled electron transport
MVA48_RS13080	COG1006	Multisubunit Na H antiporter MnhC subunit
MVA48_RS13085	COG2111	Na H antiporter
MVA48_RS13090	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MVA48_RS13090	COG2111	Na H antiporter
MVA48_RS13095	COG0473	3-isopropylmalate dehydrogenase activity
MVA48_RS13110	COG0530	calcium, potassium:sodium antiporter activity
MVA48_RS13135	COG1007	ATP synthesis coupled electron transport
MVA48_RS13170	COG0385	Bile acid
MVA48_RS13215	COG1615	UPF0182 protein
MVA48_RS13245	COG3547	Transposase (IS116 IS110 IS902 family)
MVA48_RS13260	COG0358	DNA primase activity
MVA48_RS13290	COG5002	protein histidine kinase activity
MVA48_RS13290	COG2176	DNA-directed DNA polymerase activity
MVA48_RS13480	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
MVA48_RS13485	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
MVA48_RS13490	COG4106	trans-aconitate 2-methyltransferase activity
MVA48_RS13495	COG1754	DNA topoisomerase type I activity
MVA48_RS13495	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MVA48_RS13500	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MVA48_RS13500	COG1754	DNA topoisomerase type I activity
MVA48_RS13515	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
MVA48_RS13520	COG1205	dead DEAH box helicase
MVA48_RS13520	COG1111	helicase
MVA48_RS13575	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
MVA48_RS13590	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
MVA48_RS13610	COG0242	peptide deformylase activity
MVA48_RS13615	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
MVA48_RS13625	COG0204	Acyl-transferase
MVA48_RS13625	COG0318	PFAM AMP-dependent synthetase and ligase
MVA48_RS13665	COG3180	Ammonia monooxygenase
MVA48_RS13675	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
MVA48_RS13690	COG3384	dioxygenase
MVA48_RS13700	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MVA48_RS13710	COG0596	Alpha beta hydrolase
MVA48_RS13725	COG0494	nUDIX hydrolase
MVA48_RS13730	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MVA48_RS13735	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MVA48_RS13775	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MVA48_RS13785	COG1408	metallophosphoesterase
MVA48_RS13840	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MVA48_RS13855	COG1320	monovalent cation:proton antiporter activity
MVA48_RS13860	COG2212	antiporter activity
MVA48_RS13870	COG0651	ATP synthesis coupled electron transport
MVA48_RS13875	COG1006	Multisubunit Na H antiporter MnhC subunit
MVA48_RS13880	COG2111	Na H antiporter
MVA48_RS13880	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MVA48_RS13885	COG0488	(ABC) transporter
MVA48_RS13890	COG1305	Transglutaminase-like
MVA48_RS13905	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MVA48_RS13915	COG1741	Belongs to the pirin family
MVA48_RS13925	COG3467	pyridoxamine 5'-phosphate
MVA48_RS13950	COG4608	Belongs to the ABC transporter superfamily
MVA48_RS13965	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MVA48_RS13970	COG0601	transmembrane transport
MVA48_RS13975	COG0747	negative chemotaxis
MVA48_RS13980	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
MVA48_RS13985	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
MVA48_RS14005	COG0800	Aldolase
MVA48_RS14010	COG0436	Aminotransferase
MVA48_RS14015	COG0436	Aminotransferase
MVA48_RS14025	COG1172	Belongs to the binding-protein-dependent transport system permease family
MVA48_RS14045	COG1172	Belongs to the binding-protein-dependent transport system permease family
MVA48_RS14060	COG1414	Transcriptional regulator
MVA48_RS14095	COG2217	Heavy metal translocating P-type atpase
MVA48_RS14140	COG0287	Prephenate dehydrogenase
MVA48_RS14155	COG0411	ABC transporter
MVA48_RS14170	COG0559	Belongs to the binding-protein-dependent transport system permease family
MVA48_RS14195	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
MVA48_RS14195	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
MVA48_RS14200	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
MVA48_RS14205	COG0297	glycogen (starch) synthase activity
MVA48_RS14215	COG0859	PFAM glycosyl transferase family 9
MVA48_RS14245	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MVA48_RS14250	COG5001	Diguanylate cyclase
MVA48_RS14255	COG0366	Alpha amylase catalytic
MVA48_RS14265	COG3833	ABC-type maltose transport systems, permease component
MVA48_RS14270	COG1175	transmembrane transport
MVA48_RS14285	COG1609	Transcriptional regulator
MVA48_RS14305	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MVA48_RS14305	COG4499	WXG100 protein secretion system (Wss), protein YukC
MVA48_RS14330	COG0671	phosphoesterase, PA-phosphatase related
MVA48_RS14370	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
MVA48_RS14370	COG1796	DNA polymerase
MVA48_RS14410	COG2319	Wd-40 repeat
MVA48_RS14415	COG0673	inositol 2-dehydrogenase activity
MVA48_RS14420	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
MVA48_RS14460	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
MVA48_RS14480	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
MVA48_RS14510	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
MVA48_RS14520	COG1316	TRANSCRIPTIONal
MVA48_RS14530	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MVA48_RS14540	COG0489	protein tyrosine kinase activity
MVA48_RS14550	COG0438	transferase activity, transferring glycosyl groups
MVA48_RS14565	COG5039	Polysaccharide pyruvyl transferase
MVA48_RS14575	COG3328	transposase activity
MVA48_RS14595	COG0437	4 iron, 4 sulfur cluster binding
MVA48_RS14620	COG2755	lipolytic protein G-D-S-L family
MVA48_RS14640	COG5001	Diguanylate cyclase
MVA48_RS14650	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
MVA48_RS14700	COG0463	Glycosyl transferase, family 2
MVA48_RS14780	COG0644	oxidoreductase
MVA48_RS14940	COG4608	Belongs to the ABC transporter superfamily
MVA48_RS14950	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MVA48_RS14970	COG1960	acyl-CoA dehydrogenase activity
MVA48_RS14980	COG1028	Short-chain dehydrogenase reductase Sdr
MVA48_RS14985	COG0183	Belongs to the thiolase family
MVA48_RS15000	COG2860	membrane
MVA48_RS15010	COG2200	EAL domain
MVA48_RS15015	COG0667	Aldo Keto reductase
MVA48_RS15020	COG0776	regulation of translation
MVA48_RS15055	COG0318	PFAM AMP-dependent synthetase and ligase
MVA48_RS15100	COG0561	phosphatase activity
MVA48_RS15105	COG0561	phosphatase activity
MVA48_RS15125	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
MVA48_RS15130	COG1846	Transcriptional regulator
MVA48_RS15135	COG2409	Drug exporters of the RND superfamily
MVA48_RS15140	COG2409	Drug exporters of the RND superfamily
MVA48_RS15150	COG3706	GGDEF domain
MVA48_RS15160	COG1691	(AIR) carboxylase
MVA48_RS15165	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
MVA48_RS15170	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MVA48_RS15175	COG2364	Membrane
MVA48_RS15200	COG2119	membrane
MVA48_RS15210	COG0789	Transcriptional regulator
MVA48_RS15235	COG0277	FAD linked oxidase domain protein
MVA48_RS15260	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MVA48_RS15265	COG2160	L-arabinose isomerase activity
MVA48_RS15270	COG0235	Class ii aldolase
MVA48_RS15280	COG1609	Transcriptional regulator
MVA48_RS15285	COG4214	carbohydrate transport
MVA48_RS15315	COG0318	PFAM AMP-dependent synthetase and ligase
MVA48_RS15345	COG1914	H( )-stimulated, divalent metal cation uptake system
MVA48_RS15365	COG3546	catalase activity
MVA48_RS15375	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MVA48_RS15385	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MVA48_RS15395	COG3279	Response regulator of the LytR AlgR family
MVA48_RS15400	COG3275	phosphorelay sensor kinase activity
MVA48_RS15430	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
MVA48_RS15465	COG1595	DNA-templated transcription, initiation
MVA48_RS15475	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MVA48_RS15485	COG4266	Belongs to the allantoicase family
MVA48_RS15490	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
MVA48_RS15495	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
MVA48_RS15525	COG0514	ATP-dependent DNA helicase (RecQ)
MVA48_RS15535	COG0549	Belongs to the carbamate kinase family
MVA48_RS15560	COG1304	FMN binding
MVA48_RS15565	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
MVA48_RS15570	COG2233	PERMEase
MVA48_RS15585	COG1529	Aldehyde oxidase and xanthine dehydrogenase
MVA48_RS15585	COG2080	2 iron, 2 sulfur cluster binding
MVA48_RS15605	COG1131	(ABC) transporter
MVA48_RS15610	COG4585	Histidine kinase
MVA48_RS15615	COG2197	response regulator
MVA48_RS15645	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
MVA48_RS15650	COG5001	Diguanylate cyclase
MVA48_RS15655	COG5001	Diguanylate cyclase
MVA48_RS15670	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
MVA48_RS15710	COG2197	response regulator
MVA48_RS15725	COG0659	secondary active sulfate transmembrane transporter activity
MVA48_RS15735	COG1793	dna ligase
MVA48_RS15770	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
MVA48_RS15775	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
MVA48_RS15810	COG2813	Specifically methylates the guanine in position
MVA48_RS15815	COG0596	Alpha beta hydrolase
MVA48_RS15820	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MVA48_RS15825	COG2130	NADP-dependent
MVA48_RS15840	COG1802	Transcriptional regulator
MVA48_RS15850	COG4221	oxidoreductase activity
MVA48_RS15860	COG4721	ABC-type cobalt transport system, permease component
MVA48_RS15865	COG1122	ATPase activity
MVA48_RS15945	COG2195	Cleaves the N-terminal amino acid of tripeptides
MVA48_RS15960	COG3706	GGDEF domain
MVA48_RS15975	COG1960	acyl-CoA dehydrogenase activity
MVA48_RS16010	COG3764	Sortase (surface protein transpeptidase)
MVA48_RS16035	COG0515	serine threonine protein kinase
MVA48_RS16040	COG0515	serine threonine protein kinase
MVA48_RS16045	COG1024	Enoyl-CoA hydratase
MVA48_RS16075	COG0205	6-phosphofructokinase activity
MVA48_RS16080	COG1309	transcriptional regulator
MVA48_RS16085	COG1309	transcriptional regulator
MVA48_RS16090	COG1408	metallophosphoesterase
MVA48_RS16115	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
MVA48_RS16115	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
MVA48_RS16120	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
MVA48_RS16120	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
MVA48_RS16125	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MVA48_RS16135	COG0557	exoribonuclease II activity
MVA48_RS16185	COG1960	acyl-CoA dehydrogenase activity
MVA48_RS16210	COG1716	ATPase activity
MVA48_RS16215	COG1716	ATPase activity
MVA48_RS16235	COG0768	penicillin binding
MVA48_RS16240	COG0515	serine threonine protein kinase
MVA48_RS16245	COG2815	serine threonine protein kinase
MVA48_RS16245	COG0515	serine threonine protein kinase
MVA48_RS16305	COG0187	DNA topoisomerase II activity
MVA48_RS16310	COG0531	amino acid
MVA48_RS16315	COG0702	epimerase
MVA48_RS16320	COG0702	epimerase
MVA48_RS16330	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
MVA48_RS16335	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
MVA48_RS16340	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
MVA48_RS16345	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
MVA48_RS16350	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
MVA48_RS16355	COG0592	DNA-directed DNA polymerase activity
MVA48_RS16365	COG0230	Belongs to the bacterial ribosomal protein bL34 family
MVA48_RS16375	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
MVA48_RS16380	COG0706	membrane insertase activity
MVA48_RS16395	COG1192	Involved in chromosome partitioning
MVA48_RS16410	COG1181	Belongs to the D-alanine--D-alanine ligase family
MVA48_RS16415	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MVA48_RS16420	COG0860	N-Acetylmuramoyl-L-alanine amidase
MVA48_RS16420	COG3409	Peptidoglycan-binding domain 1 protein
MVA48_RS16430	COG3118	belongs to the thioredoxin family
MVA48_RS16430	COG0492	ferredoxin-NADP+ reductase activity
MVA48_RS16465	COG0617	tRNA 3'-terminal CCA addition
MVA48_RS16480	COG1678	Uncharacterized ACR, COG1678
MVA48_RS16495	COG1695	Transcriptional regulator
MVA48_RS16505	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MVA48_RS16525	COG0360	Binds together with S18 to 16S ribosomal RNA
MVA48_RS16535	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
MVA48_RS16540	COG0359	binds to the 23S rRNA
MVA48_RS16590	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MVA48_RS16605	COG2268	Band 7 protein
MVA48_RS16615	COG0596	Alpha beta hydrolase
MVA48_RS16645	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MVA48_RS16655	COG3920	Histidine kinase
MVA48_RS16655	COG2202	Pas domain
MVA48_RS16680	COG0367	asparagine synthase
MVA48_RS16705	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MVA48_RS16710	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MVA48_RS16715	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
MVA48_RS16755	COG0643	Histidine kinase
MVA48_RS16755	COG0784	Response regulator, receiver
MVA48_RS16755	COG2198	Histidine kinase
MVA48_RS16770	COG2201	protein-glutamate methylesterase activity
MVA48_RS16775	COG2201	protein-glutamate methylesterase activity
MVA48_RS16780	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
MVA48_RS16785	COG0745	RESPONSE REGULATOR receiver
MVA48_RS16795	COG0745	RESPONSE REGULATOR receiver
MVA48_RS16825	COG1950	PFAM Membrane protein of
MVA48_RS16830	COG2902	Dehydrogenase
MVA48_RS16855	COG4191	Histidine kinase
MVA48_RS16860	COG3022	response to hydroperoxide
MVA48_RS16880	COG1316	TRANSCRIPTIONal
MVA48_RS16890	COG0640	Transcriptional regulator
MVA48_RS16895	COG1864	DNA RNA non-specific endonuclease
MVA48_RS16895	COG3591	Belongs to the peptidase S1B family
MVA48_RS16930	COG2192	nodulation
MVA48_RS16955	COG0725	ABC transporter, periplasmic molybdate-binding protein
MVA48_RS16985	COG3386	PFAM SMP-30 Gluconolaconase
MVA48_RS17000	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
MVA48_RS17020	COG0577	efflux transmembrane transporter activity
MVA48_RS17020	COG1136	(ABC) transporter
MVA48_RS17065	COG5001	Diguanylate cyclase
MVA48_RS17065	COG3300	MHYT domain
MVA48_RS17085	COG2814	Major facilitator Superfamily
MVA48_RS17095	COG2814	Major facilitator Superfamily
MVA48_RS17130	COG0586	Pfam SNARE associated Golgi protein
MVA48_RS17135	COG0402	S-adenosylhomocysteine deaminase activity
MVA48_RS17150	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
MVA48_RS17190	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
MVA48_RS17210	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MVA48_RS17220	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
MVA48_RS17230	COG0668	transmembrane transport
MVA48_RS17260	COG1120	ATPase activity
MVA48_RS17265	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MVA48_RS17275	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MVA48_RS17280	COG0386	Belongs to the glutathione peroxidase family
MVA48_RS17290	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
MVA48_RS17300	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MVA48_RS17315	COG0604	alcohol dehydrogenase
MVA48_RS17315	COG1028	Short-chain dehydrogenase reductase Sdr
MVA48_RS17315	COG3321	synthase
MVA48_RS17320	COG0366	Alpha amylase catalytic
MVA48_RS17345	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
MVA48_RS17350	COG2070	2-Nitropropane dioxygenase
MVA48_RS17365	COG0640	Transcriptional regulator
MVA48_RS17380	COG1902	pentaerythritol trinitrate reductase activity
MVA48_RS17385	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
MVA48_RS17445	COG2409	Drug exporters of the RND superfamily
MVA48_RS17460	COG1522	sequence-specific DNA binding
MVA48_RS17470	COG0022	dehydrogenase e1 component
MVA48_RS17475	COG0508	dehydrogenase complex catalyzes the overall conversion of
MVA48_RS17495	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MVA48_RS17495	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MVA48_RS17500	COG1105	Belongs to the carbohydrate kinase PfkB family
MVA48_RS17505	COG1349	DNA-binding transcription factor activity
MVA48_RS17510	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MVA48_RS17545	COG1960	acyl-CoA dehydrogenase activity
MVA48_RS17565	COG1309	transcriptional regulator
MVA48_RS17610	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MVA48_RS17620	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MVA48_RS17665	COG0840	transmembrane signaling receptor activity
MVA48_RS17685	COG2807	transmembrane transport
MVA48_RS17690	COG0247	lactate metabolic process
MVA48_RS17690	COG2181	nitrate reductase activity
MVA48_RS17695	COG0247	lactate metabolic process
MVA48_RS17695	COG2181	nitrate reductase activity
MVA48_RS17705	COG0443	Heat shock 70 kDa protein
MVA48_RS17710	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
MVA48_RS17715	COG0484	heat shock protein binding
MVA48_RS17720	COG0789	Transcriptional regulator
MVA48_RS17735	COG1846	Transcriptional regulator
MVA48_RS17750	COG1136	(ABC) transporter
MVA48_RS17755	COG0577	efflux transmembrane transporter activity
MVA48_RS17755	COG1136	(ABC) transporter
MVA48_RS17780	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
MVA48_RS17785	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
MVA48_RS17790	COG0277	FAD linked oxidase domain protein
MVA48_RS17815	COG1129	ABC transporter
MVA48_RS17820	COG1172	Belongs to the binding-protein-dependent transport system permease family
MVA48_RS17835	COG0584	glycerophosphoryl diester phosphodiesterase
MVA48_RS17840	COG1162	GTPase activity
MVA48_RS17845	COG0151	Belongs to the GarS family
MVA48_RS17855	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
MVA48_RS17860	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
MVA48_RS17875	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MVA48_RS17880	COG0047	phosphoribosylformylglycinamidine synthase activity
MVA48_RS17885	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MVA48_RS17910	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MVA48_RS17925	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
MVA48_RS17935	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
MVA48_RS17945	COG1172	Belongs to the binding-protein-dependent transport system permease family
MVA48_RS17960	COG0739	heme binding
MVA48_RS17975	COG0318	PFAM AMP-dependent synthetase and ligase
MVA48_RS17980	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MVA48_RS18115	COG1960	acyl-CoA dehydrogenase activity
MVA48_RS18135	COG1959	2 iron, 2 sulfur cluster binding
MVA48_RS18135	COG1295	ribonuclease BN
MVA48_RS18155	COG1960	acyl-CoA dehydrogenase activity
MVA48_RS18175	COG1643	Atp-dependent helicase
MVA48_RS18180	COG1643	Atp-dependent helicase
MVA48_RS18220	COG1218	3'(2'),5'-bisphosphate nucleotidase
MVA48_RS18235	COG2205	protein histidine kinase activity
MVA48_RS18240	COG0745	RESPONSE REGULATOR receiver
MVA48_RS18245	COG2375	cellular response to nickel ion
MVA48_RS18295	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
MVA48_RS18305	COG0573	inorganic phosphate transmembrane transporter activity
MVA48_RS18310	COG0581	inorganic phosphate transmembrane transporter activity
MVA48_RS18315	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
MVA48_RS18325	COG0456	acetyltransferase
MVA48_RS18330	COG0745	RESPONSE REGULATOR receiver
MVA48_RS18355	COG2897	thiosulfate sulfurtransferase activity
MVA48_RS18395	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
MVA48_RS18410	COG0354	folic acid binding
MVA48_RS18415	COG3246	L-lysine catabolic process to acetate
MVA48_RS18480	COG0812	UDP-N-acetylmuramate dehydrogenase activity
MVA48_RS18490	COG0297	glycogen (starch) synthase activity
MVA48_RS18500	COG0477	Major facilitator Superfamily
MVA48_RS18505	COG0156	8-amino-7-oxononanoate synthase activity
MVA48_RS18515	COG0588	phosphoglycerate mutase activity
MVA48_RS18525	COG5002	protein histidine kinase activity
MVA48_RS18530	COG0745	RESPONSE REGULATOR receiver
MVA48_RS18545	COG4977	sequence-specific DNA binding
MVA48_RS18565	COG0693	protein deglycase activity
MVA48_RS18570	COG0693	protein deglycase activity
MVA48_RS18610	COG1595	DNA-templated transcription, initiation
MVA48_RS18630	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
MVA48_RS18635	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
MVA48_RS18640	COG0181	hydroxymethylbilane synthase activity
MVA48_RS18645	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MVA48_RS18645	COG1648	precorrin-2 dehydrogenase activity
MVA48_RS18655	COG0113	porphobilinogen synthase activity
MVA48_RS18665	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
MVA48_RS18670	COG0406	alpha-ribazole phosphatase activity
MVA48_RS18675	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MVA48_RS18680	COG0785	Cytochrome C biogenesis protein
MVA48_RS18690	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MVA48_RS18705	COG1522	sequence-specific DNA binding
MVA48_RS18725	COG4948	Mandelate Racemase Muconate Lactonizing
MVA48_RS18730	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
MVA48_RS18735	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
MVA48_RS18755	COG2226	methyltransferase
MVA48_RS18770	COG0644	oxidoreductase
MVA48_RS18775	COG0644	oxidoreductase
MVA48_RS18790	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MVA48_RS18795	COG0649	NAD binding
MVA48_RS18815	COG1034	ATP synthesis coupled electron transport
MVA48_RS18820	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
MVA48_RS18825	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MVA48_RS18835	COG0713	ATP synthesis coupled electron transport
MVA48_RS18850	COG1007	ATP synthesis coupled electron transport
MVA48_RS18855	COG0142	geranyltranstransferase activity
MVA48_RS18865	COG1013	pyruvate-flavodoxin oxidoreductase activity
MVA48_RS18870	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
MVA48_RS18870	COG0674	pyruvate-flavodoxin oxidoreductase activity
MVA48_RS18875	COG0501	Belongs to the peptidase M48B family
MVA48_RS18880	COG3848	Pyruvate phosphate dikinase
MVA48_RS18880	COG0574	Belongs to the PEP-utilizing enzyme family
MVA48_RS18885	COG1309	transcriptional regulator
MVA48_RS18890	COG1666	GTP binding
MVA48_RS18935	COG0267	Belongs to the bacterial ribosomal protein bL33 family
MVA48_RS18955	COG0436	Aminotransferase
MVA48_RS18975	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
MVA48_RS18980	COG0081	regulation of translation
MVA48_RS18990	COG0222	ribosome binding
MVA48_RS19005	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
MVA48_RS19035	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
MVA48_RS19055	COG0085	RNA polymerase activity
MVA48_RS19060	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MVA48_RS19065	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MVA48_RS19070	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
MVA48_RS19075	COG0049	tRNA binding
MVA48_RS19080	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MVA48_RS19085	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MVA48_RS19095	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
MVA48_RS19110	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
MVA48_RS19115	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
MVA48_RS19125	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
MVA48_RS19130	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
MVA48_RS19135	COG0255	Belongs to the universal ribosomal protein uL29 family
MVA48_RS19140	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
MVA48_RS19145	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
MVA48_RS19150	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
MVA48_RS19155	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
MVA48_RS19160	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
MVA48_RS19165	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
MVA48_RS19170	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
MVA48_RS19175	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
MVA48_RS19180	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
MVA48_RS19185	COG1841	ribosomal large subunit assembly
MVA48_RS19190	COG0200	Binds to the 23S rRNA
MVA48_RS19200	COG0563	adenylate kinase activity
MVA48_RS19210	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
MVA48_RS19215	COG0257	Belongs to the bacterial ribosomal protein bL36 family
MVA48_RS19220	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
MVA48_RS19225	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
MVA48_RS19230	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
MVA48_RS19240	COG0202	RNA polymerase activity
MVA48_RS19250	COG0101	tRNA pseudouridine synthase activity
MVA48_RS19260	COG0746	molybdenum cofactor guanylyltransferase activity
MVA48_RS19265	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
MVA48_RS19275	COG0521	Mo-molybdopterin cofactor biosynthetic process
MVA48_RS19280	COG0315	cyclic pyranopterin monophosphate synthase activity
MVA48_RS19295	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
MVA48_RS19300	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
MVA48_RS19305	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MVA48_RS19310	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
MVA48_RS19325	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
MVA48_RS19340	COG1573	uracil-dna glycosylase
MVA48_RS19345	COG0802	atpase or kinase
MVA48_RS19365	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
MVA48_RS19375	COG2264	protein methyltransferase activity
MVA48_RS19380	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
MVA48_RS19385	COG0459	protein refolding
MVA48_RS19395	COG2197	response regulator
MVA48_RS19415	COG0516	GMP reductase activity
MVA48_RS19420	COG0519	Catalyzes the synthesis of GMP from XMP
MVA48_RS19420	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MVA48_RS19445	COG2197	response regulator
MVA48_RS19450	COG2801	Transposase and inactivated derivatives
MVA48_RS19450	COG3415	Transposase
MVA48_RS19465	COG1595	DNA-templated transcription, initiation
MVA48_RS19505	COG0739	heme binding
MVA48_RS19520	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
MVA48_RS19530	COG0045	succinate-CoA ligase (ADP-forming) activity
MVA48_RS19555	COG0138	bifunctional purine biosynthesis protein purh
MVA48_RS19570	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
MVA48_RS19585	COG0538	isocitrate dehydrogenase activity
MVA48_RS19595	COG2340	Cysteine-rich secretory protein family
MVA48_RS19600	COG1253	flavin adenine dinucleotide binding
MVA48_RS19610	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MVA48_RS19615	COG0180	Tryptophanyl-tRNA synthetase
MVA48_RS19630	COG1686	Belongs to the peptidase S11 family
MVA48_RS19635	COG1744	ABC transporter substrate-binding protein PnrA-like
MVA48_RS19640	COG3845	ABC transporter
MVA48_RS19645	COG4603	Belongs to the binding-protein-dependent transport system permease family
MVA48_RS19650	COG1079	Belongs to the binding-protein-dependent transport system permease family
MVA48_RS19685	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
MVA48_RS19690	COG0513	Belongs to the DEAD box helicase family
MVA48_RS19700	COG2318	DinB family
MVA48_RS19710	COG0531	amino acid
MVA48_RS19715	COG1012	belongs to the aldehyde dehydrogenase family
MVA48_RS19720	COG1012	belongs to the aldehyde dehydrogenase family
MVA48_RS19725	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
MVA48_RS19760	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MVA48_RS19765	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MVA48_RS19770	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MVA48_RS19795	COG3629	intracellular signal transduction
MVA48_RS19795	COG3903	Transcriptional regulator
MVA48_RS19810	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
MVA48_RS19815	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
MVA48_RS19815	COG1473	amidohydrolase
MVA48_RS19865	COG4770	biotin carboxylase activity
MVA48_RS19870	COG4770	biotin carboxylase activity
MVA48_RS19875	COG0424	maF-like protein
MVA48_RS19885	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
MVA48_RS19895	COG0671	phosphoesterase, PA-phosphatase related
MVA48_RS19905	COG0277	FAD linked oxidase domain protein
MVA48_RS19925	COG0420	3'-5' exonuclease activity
MVA48_RS19930	COG0419	ATPase involved in DNA repair
MVA48_RS20000	COG1316	TRANSCRIPTIONal
MVA48_RS20065	COG0438	transferase activity, transferring glycosyl groups
MVA48_RS20095	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
MVA48_RS20110	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MVA48_RS20120	COG0438	transferase activity, transferring glycosyl groups
MVA48_RS20130	COG0438	transferase activity, transferring glycosyl groups
MVA48_RS20175	COG0778	Nitroreductase
MVA48_RS20175	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
MVA48_RS20180	COG0391	Required for morphogenesis under gluconeogenic growth conditions
MVA48_RS20210	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MVA48_RS20225	COG2354	Protein conserved in bacteria
MVA48_RS20235	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
MVA48_RS20245	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
MVA48_RS20255	COG5000	phosphorelay sensor kinase activity
MVA48_RS20255	COG5002	protein histidine kinase activity
MVA48_RS20260	COG5401	PFAM Sporulation and spore germination
MVA48_RS20265	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
MVA48_RS20275	COG0653	protein targeting
MVA48_RS20280	COG1024	Enoyl-CoA hydratase
MVA48_RS20315	COG0489	protein tyrosine kinase activity
MVA48_RS20355	COG0494	nUDIX hydrolase
MVA48_RS20375	COG0613	PHP domain protein
MVA48_RS20390	COG0596	Alpha beta hydrolase
MVA48_RS20405	COG0513	Belongs to the DEAD box helicase family
MVA48_RS20415	COG4221	oxidoreductase activity
MVA48_RS20435	COG0596	Alpha beta hydrolase
MVA48_RS20490	COG0210	DNA helicase
MVA48_RS20495	COG0596	Alpha beta hydrolase
MVA48_RS20505	COG2890	protein-(glutamine-N5) methyltransferase activity
MVA48_RS20520	COG0612	Peptidase, M16
MVA48_RS20565	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
MVA48_RS20590	COG3480	Lon protease (S16) C-terminal proteolytic domain
MVA48_RS20595	COG1615	UPF0182 protein
MVA48_RS20610	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MVA48_RS20610	COG0425	Belongs to the sulfur carrier protein TusA family
MVA48_RS20615	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MVA48_RS20625	COG1937	Protein conserved in bacteria
MVA48_RS20640	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
MVA48_RS20660	COG0346	lactoylglutathione lyase activity
MVA48_RS20685	COG0667	Aldo Keto reductase
MVA48_RS20690	COG3608	succinylglutamate desuccinylase aspartoacylase
MVA48_RS20690	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
MVA48_RS20695	COG1070	Carbohydrate kinase
MVA48_RS20700	COG0483	inositol monophosphate 1-phosphatase activity
MVA48_RS20720	COG1162	GTPase activity
MVA48_RS20730	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
MVA48_RS20735	COG1012	belongs to the aldehyde dehydrogenase family
MVA48_RS20740	COG2135	peptidase activity
MVA48_RS20755	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
MVA48_RS20760	COG1595	DNA-templated transcription, initiation
MVA48_RS20765	COG5662	AntiSigma factor
MVA48_RS20770	COG0439	Biotin carboxylase
MVA48_RS20775	COG2062	phosphohistidine phosphatase, SixA
MVA48_RS20800	COG1597	lipid kinase activity
MVA48_RS20820	COG1183	phosphatidylcholine synthase activity
MVA48_RS20825	COG0688	phosphatidylethanolamine metabolic process
MVA48_RS20875	COG0508	dehydrogenase complex catalyzes the overall conversion of
MVA48_RS20875	COG0567	Dehydrogenase, E1 component
MVA48_RS20880	COG0567	Dehydrogenase, E1 component
MVA48_RS20880	COG0508	dehydrogenase complex catalyzes the overall conversion of
MVA48_RS20890	COG1131	(ABC) transporter
MVA48_RS20900	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
MVA48_RS20905	COG0488	(ABC) transporter
MVA48_RS20915	COG0456	acetyltransferase
MVA48_RS20920	COG3243	poly(R)-hydroxyalkanoic acid synthase
MVA48_RS20930	COG0318	PFAM AMP-dependent synthetase and ligase
MVA48_RS20935	COG1028	Short-chain dehydrogenase reductase Sdr
MVA48_RS20940	COG1073	alpha beta
MVA48_RS20965	COG0018	arginyl-trna synthetase
MVA48_RS20970	COG0019	diaminopimelate decarboxylase activity
MVA48_RS20975	COG0460	homoserine dehydrogenase
MVA48_RS20980	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
MVA48_RS20985	COG0083	homoserine kinase activity
MVA48_RS21000	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
MVA48_RS21005	COG2890	protein-(glutamine-N5) methyltransferase activity
MVA48_RS21015	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MVA48_RS21030	COG0356	it plays a direct role in the translocation of protons across the membrane
MVA48_RS21035	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MVA48_RS21040	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
MVA48_RS21045	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MVA48_RS21050	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
MVA48_RS21060	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
MVA48_RS21065	COG0355	proton-transporting ATP synthase activity, rotational mechanism
MVA48_RS21080	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
MVA48_RS21090	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
MVA48_RS21090	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
MVA48_RS21095	COG1024	Enoyl-CoA hydratase
MVA48_RS21100	COG1301	dicarboxylic acid transport
MVA48_RS21110	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
MVA48_RS21170	COG0346	lactoylglutathione lyase activity
MVA48_RS21175	COG0183	Belongs to the thiolase family
MVA48_RS21200	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
MVA48_RS21200	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
MVA48_RS21230	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
MVA48_RS21250	COG0366	Alpha amylase catalytic
MVA48_RS21255	COG0058	SHG alpha-glucan phosphorylase activity
MVA48_RS21275	COG1119	ATPase activity
MVA48_RS21300	COG3842	ATPase activity
MVA48_RS21310	COG2086	electron transfer activity
MVA48_RS21315	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
MVA48_RS21330	COG0482	sulfurtransferase activity
MVA48_RS21345	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
MVA48_RS21355	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MVA48_RS21360	COG0154	amidase activity
MVA48_RS21365	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MVA48_RS21400	COG0129	dihydroxy-acid dehydratase activity
MVA48_RS21415	COG0440	acetolactate synthase activity
MVA48_RS21420	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
MVA48_RS21440	COG0473	3-isopropylmalate dehydrogenase activity
MVA48_RS21450	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MVA48_RS21465	COG0179	Fumarylacetoacetate (FAA) hydrolase
MVA48_RS21470	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MVA48_RS21500	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
MVA48_RS21520	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
MVA48_RS21525	COG0066	3-isopropylmalate dehydratase activity
MVA48_RS21535	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
MVA48_RS21540	COG1920	GTP binding
MVA48_RS21545	COG1920	GTP binding
MVA48_RS21555	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
MVA48_RS21560	COG0626	cystathionine gamma-synthase activity
MVA48_RS21565	COG1183	phosphatidylcholine synthase activity
MVA48_RS21570	COG1181	Belongs to the D-alanine--D-alanine ligase family
MVA48_RS21605	COG0227	Belongs to the bacterial ribosomal protein bL28 family
MVA48_RS21610	COG1461	Dihydroxyacetone kinase
MVA48_RS21620	COG0742	ribosomal rna small subunit methyltransferase
MVA48_RS21625	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
MVA48_RS21640	COG0333	Belongs to the bacterial ribosomal protein bL32 family
MVA48_RS21645	COG0571	ribonuclease III activity
MVA48_RS21650	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
MVA48_RS21655	COG1254	Belongs to the acylphosphatase family
MVA48_RS21675	COG1196	nuclear chromosome segregation
MVA48_RS21700	COG1122	ATPase activity
MVA48_RS21715	COG0310	cobalt ion transport
MVA48_RS21730	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
MVA48_RS21775	COG0442	prolyl-tRNA aminoacylation
MVA48_RS21780	COG0228	four-way junction DNA binding
MVA48_RS21790	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
MVA48_RS21795	COG0336	Belongs to the RNA methyltransferase TrmD family
MVA48_RS21800	COG0494	nUDIX hydrolase
MVA48_RS21805	COG0335	large ribosomal subunit rRNA binding
MVA48_RS21815	COG2197	response regulator
MVA48_RS21820	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
MVA48_RS21855	COG4974	Belongs to the 'phage' integrase family
MVA48_RS21860	COG1191	sigma factor activity
MVA48_RS21865	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MVA48_RS21880	COG0052	Belongs to the universal ribosomal protein uS2 family
MVA48_RS21890	COG0528	UMP kinase activity
MVA48_RS21895	COG0233	cytoplasmic translational termination
MVA48_RS21900	COG0575	Belongs to the CDS family
MVA48_RS21915	COG2326	polyphosphate kinase activity
MVA48_RS21940	COG0820	rRNA (adenine-C2-)-methyltransferase activity
MVA48_RS21955	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
MVA48_RS21960	COG0750	zinc metalloprotease
MVA48_RS21970	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
MVA48_RS22000	COG0779	Required for maturation of 30S ribosomal subunits
MVA48_RS22020	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
MVA48_RS22035	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
MVA48_RS22045	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
MVA48_RS22050	COG0534	Mate efflux family protein
MVA48_RS22055	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
MVA48_RS22060	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
MVA48_RS22070	COG1691	(AIR) carboxylase
MVA48_RS22080	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MVA48_RS22090	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
MVA48_RS22095	COG1185	polyribonucleotide nucleotidyltransferase activity
MVA48_RS22100	COG0612	Peptidase, M16
MVA48_RS22110	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
MVA48_RS22140	COG0697	spore germination
MVA48_RS22145	COG3214	Protein conserved in bacteria
MVA48_RS22155	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
MVA48_RS22160	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
MVA48_RS22170	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MVA48_RS22185	COG1674	ftsk spoiiie
MVA48_RS22195	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MVA48_RS22210	COG1396	sequence-specific DNA binding
MVA48_RS22225	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MVA48_RS22230	COG1842	Phage shock protein A
MVA48_RS22235	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
MVA48_RS22250	COG1201	RNA secondary structure unwinding
MVA48_RS22260	COG2814	Major facilitator Superfamily
MVA48_RS22270	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
MVA48_RS22290	COG0765	amino acid transport
MVA48_RS22300	COG0765	amino acid transport
MVA48_RS22305	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MVA48_RS22310	COG1126	abc transporter atp-binding protein
MVA48_RS22315	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MVA48_RS22320	COG1196	nuclear chromosome segregation
MVA48_RS22330	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
MVA48_RS22335	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
MVA48_RS22340	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MVA48_RS22375	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
MVA48_RS22380	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MVA48_RS22455	COG2189	Belongs to the N(4) N(6)-methyltransferase family
MVA48_RS22515	COG3739	integral membrane protein
MVA48_RS22525	COG2208	phosphoserine phosphatase activity
MVA48_RS22525	COG2770	Histidine kinase
MVA48_RS22570	COG0667	Aldo Keto reductase
MVA48_RS22615	COG1012	belongs to the aldehyde dehydrogenase family
MVA48_RS22620	COG2146	nitrite reductase [NAD(P)H] activity
MVA48_RS22640	COG2508	Transcriptional regulator
MVA48_RS22650	COG3069	C4-dicarboxylate transmembrane transporter activity
MVA48_RS22660	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MVA48_RS22675	COG0640	Transcriptional regulator
MVA48_RS22715	COG2318	DinB family
MVA48_RS22725	COG1028	Short-chain dehydrogenase reductase Sdr
MVA48_RS22740	COG3845	ABC transporter
MVA48_RS22745	COG4603	Belongs to the binding-protein-dependent transport system permease family
MVA48_RS22750	COG1079	Belongs to the binding-protein-dependent transport system permease family
MVA48_RS22755	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MVA48_RS22785	COG1070	Carbohydrate kinase
MVA48_RS22790	COG1940	carbohydrate kinase activity
MVA48_RS22800	COG1846	Transcriptional regulator
MVA48_RS22800	COG1940	carbohydrate kinase activity
MVA48_RS22805	COG1129	ABC transporter
MVA48_RS22810	COG1172	Belongs to the binding-protein-dependent transport system permease family
MVA48_RS22815	COG1879	ABC-type sugar transport system periplasmic component
MVA48_RS22820	COG0673	inositol 2-dehydrogenase activity
MVA48_RS22855	COG0513	Belongs to the DEAD box helicase family
MVA48_RS22895	COG0183	Belongs to the thiolase family
MVA48_RS22920	COG2124	cytochrome p450
MVA48_RS22935	COG2197	response regulator
MVA48_RS22940	COG4585	Histidine kinase
MVA48_RS22975	COG0596	Alpha beta hydrolase
MVA48_RS23010	COG1309	transcriptional regulator
MVA48_RS23040	COG1053	succinate dehydrogenase
MVA48_RS23075	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MVA48_RS23080	COG2124	cytochrome p450
MVA48_RS23085	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MVA48_RS23090	COG2124	cytochrome p450
MVA48_RS23095	COG0657	acetylesterase activity
MVA48_RS23125	COG4221	oxidoreductase activity
MVA48_RS23160	COG2030	dehydratase
MVA48_RS23165	COG2186	Transcriptional regulator
MVA48_RS23185	COG1024	Enoyl-CoA hydratase
MVA48_RS23195	COG0183	Belongs to the thiolase family
MVA48_RS23230	COG1028	Short-chain dehydrogenase reductase Sdr
MVA48_RS23235	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MVA48_RS23245	COG1012	belongs to the aldehyde dehydrogenase family
MVA48_RS23250	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MVA48_RS23290	COG2814	Major facilitator Superfamily
MVA48_RS23295	COG1233	COG1233 Phytoene dehydrogenase and related
MVA48_RS23300	COG1028	Short-chain dehydrogenase reductase Sdr
MVA48_RS23315	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
MVA48_RS23315	COG4651	solute:proton antiporter activity
MVA48_RS23325	COG1228	amidohydrolase
MVA48_RS23340	COG0318	PFAM AMP-dependent synthetase and ligase
MVA48_RS23350	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
MVA48_RS23355	COG2050	protein possibly involved in aromatic compounds catabolism
MVA48_RS23370	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
MVA48_RS23395	COG4585	Histidine kinase
MVA48_RS23420	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
MVA48_RS23435	COG1012	belongs to the aldehyde dehydrogenase family
MVA48_RS23440	COG1012	belongs to the aldehyde dehydrogenase family
MVA48_RS23445	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
MVA48_RS23465	COG2318	DinB family
MVA48_RS23485	COG0651	ATP synthesis coupled electron transport
MVA48_RS23490	COG1007	ATP synthesis coupled electron transport
MVA48_RS23495	COG0318	PFAM AMP-dependent synthetase and ligase
MVA48_RS23500	COG0318	PFAM AMP-dependent synthetase and ligase
MVA48_RS23505	COG0318	PFAM AMP-dependent synthetase and ligase
MVA48_RS23520	COG0444	Belongs to the ABC transporter superfamily
MVA48_RS23525	COG1129	ABC transporter
MVA48_RS23530	COG1129	ABC transporter
MVA48_RS23535	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
MVA48_RS23540	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MVA48_RS23605	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
MVA48_RS23640	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
MVA48_RS23665	COG1196	nuclear chromosome segregation
MVA48_RS23675	COG0745	RESPONSE REGULATOR receiver
MVA48_RS23685	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate