locus-tag	class	description
B5J99_RS00010	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
B5J99_RS00015	COG0101	tRNA pseudouridine synthase activity
B5J99_RS00020	COG0367	asparagine synthase
B5J99_RS00045	COG3267	Type II secretory pathway component ExeA
B5J99_RS00045	COG3409	Peptidoglycan-binding domain 1 protein
B5J99_RS00075	COG2226	methyltransferase
B5J99_RS00085	COG1024	Enoyl-CoA hydratase
B5J99_RS00095	COG0625	glutathione transferase activity
B5J99_RS00100	COG0745	RESPONSE REGULATOR receiver
B5J99_RS00105	COG0436	Aminotransferase
B5J99_RS00110	COG3243	poly(R)-hydroxyalkanoic acid synthase
B5J99_RS00140	COG4181	ATPase activity
B5J99_RS00155	COG2365	Tyrosine phosphatase family
B5J99_RS00185	COG0729	surface antigen
B5J99_RS00190	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
B5J99_RS00195	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
B5J99_RS00200	COG2084	Dehydrogenase
B5J99_RS00205	COG1574	metal-dependent hydrolase with the TIM-barrel fold
B5J99_RS00220	COG1385	rRNA (uridine-N3-)-methyltransferase activity
B5J99_RS00230	COG4771	TonB-dependent receptor
B5J99_RS00245	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B5J99_RS00250	COG4133	protoheme IX ABC transporter activity
B5J99_RS00255	COG2154	pterin-4-alpha-carbinolamine dehydratase
B5J99_RS00270	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
B5J99_RS00280	COG3138	arginine N-succinyltransferase
B5J99_RS00285	COG3724	N-succinylarginine dihydrolase activity
B5J99_RS00300	COG1970	mechanosensitive ion channel activity
B5J99_RS00310	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
B5J99_RS00325	COG0189	ligase activity
B5J99_RS00330	COG4067	protein conserved in archaea
B5J99_RS00330	COG0189	ligase activity
B5J99_RS00335	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
B5J99_RS00345	COG0563	adenylate kinase activity
B5J99_RS00350	COG0201	protein transport
B5J99_RS00355	COG0200	Binds to the 23S rRNA
B5J99_RS00360	COG1841	ribosomal large subunit assembly
B5J99_RS00365	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
B5J99_RS00370	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
B5J99_RS00375	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
B5J99_RS00380	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
B5J99_RS00385	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
B5J99_RS00390	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
B5J99_RS00395	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
B5J99_RS00400	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
B5J99_RS00405	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
B5J99_RS00410	COG0255	Belongs to the universal ribosomal protein uL29 family
B5J99_RS00415	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
B5J99_RS00420	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
B5J99_RS00425	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
B5J99_RS00430	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
B5J99_RS00435	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
B5J99_RS00440	COG0089	rRNA binding
B5J99_RS00445	COG0088	Forms part of the polypeptide exit tunnel
B5J99_RS00455	COG0051	transcription antitermination factor activity, RNA binding
B5J99_RS00460	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B5J99_RS00465	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
B5J99_RS00470	COG0049	tRNA binding
B5J99_RS00475	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
B5J99_RS00485	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B5J99_RS00490	COG0154	amidase activity
B5J99_RS00495	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B5J99_RS00505	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
B5J99_RS00515	COG1643	Atp-dependent helicase
B5J99_RS00520	COG0534	Mate efflux family protein
B5J99_RS00525	COG0142	geranyltranstransferase activity
B5J99_RS00530	COG1605	Chorismate mutase
B5J99_RS00530	COG0287	Prephenate dehydrogenase
B5J99_RS00555	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B5J99_RS00560	COG0488	(ABC) transporter
B5J99_RS00590	COG0667	Aldo Keto reductase
B5J99_RS00600	COG1862	Preprotein translocase
B5J99_RS00605	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B5J99_RS00610	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B5J99_RS00625	COG1704	LemA family
B5J99_RS00640	COG0730	response to heat
B5J99_RS00655	COG0450	alkyl hydroperoxide reductase
B5J99_RS00670	COG2391	methyltransferase activity
B5J99_RS00735	COG0523	cobalamin synthesis protein
B5J99_RS00750	COG1136	(ABC) transporter
B5J99_RS00770	COG0642	Histidine kinase
B5J99_RS00775	COG0745	RESPONSE REGULATOR receiver
B5J99_RS00785	COG1136	(ABC) transporter
B5J99_RS00810	COG0367	asparagine synthase
B5J99_RS00825	COG1017	nitric oxide dioxygenase activity
B5J99_RS00825	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
B5J99_RS00830	COG0625	glutathione transferase activity
B5J99_RS00850	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
B5J99_RS00875	COG4372	Transposase
B5J99_RS00915	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
B5J99_RS00920	COG0657	acetylesterase activity
B5J99_RS00925	COG1028	Short-chain dehydrogenase reductase Sdr
B5J99_RS00950	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B5J99_RS00970	COG4771	TonB-dependent receptor
B5J99_RS00980	COG2267	carboxylic ester hydrolase activity
B5J99_RS00995	COG1028	Short-chain dehydrogenase reductase Sdr
B5J99_RS01035	COG2948	multi-organism process
B5J99_RS01065	COG3451	type IV secretory pathway VirB4
B5J99_RS01080	COG4962	Type ii secretion system protein e
B5J99_RS01100	COG2003	Belongs to the UPF0758 family
B5J99_RS01120	COG0741	lytic transglycosylase activity
B5J99_RS01155	COG5489	Protein of unknown function (DUF736)
B5J99_RS01160	COG1648	precorrin-2 dehydrogenase activity
B5J99_RS01160	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
B5J99_RS01165	COG0243	molybdopterin cofactor binding
B5J99_RS01170	COG2146	nitrite reductase [NAD(P)H] activity
B5J99_RS01175	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B5J99_RS01185	COG2223	nitrite transmembrane transporter activity
B5J99_RS01190	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
B5J99_RS01190	COG1116	anion transmembrane transporter activity
B5J99_RS01230	COG5001	Diguanylate cyclase
B5J99_RS01230	COG3300	MHYT domain
B5J99_RS01300	COG2372	response to copper ion
B5J99_RS01315	COG1937	Protein conserved in bacteria
B5J99_RS01385	COG4974	Belongs to the 'phage' integrase family
B5J99_RS01390	COG0517	IMP dehydrogenase activity
B5J99_RS01395	COG5001	Diguanylate cyclase
B5J99_RS01395	COG4251	negative regulation of phosphorylation
B5J99_RS01395	COG3706	GGDEF domain
B5J99_RS01395	COG2203	Gaf domain
B5J99_RS01420	COG3547	Transposase (IS116 IS110 IS902 family)
B5J99_RS01455	COG1475	DNA binding
B5J99_RS01470	COG2771	luxR family
B5J99_RS01485	COG4206	TonB-dependent receptor
B5J99_RS01510	COG3916	Acyl-homoserine-lactone synthase
B5J99_RS01530	COG3712	iron ion homeostasis
B5J99_RS01575	COG0842	Transport permease protein
B5J99_RS01585	COG0187	DNA topoisomerase II activity
B5J99_RS01600	COG0583	DNA-binding transcription factor activity
B5J99_RS01605	COG2967	ApaG domain
B5J99_RS01630	COG3046	protein related to deoxyribodipyrimidine photolyase
B5J99_RS01635	COG1960	acyl-CoA dehydrogenase activity
B5J99_RS01640	COG5002	protein histidine kinase activity
B5J99_RS01640	COG5001	Diguanylate cyclase
B5J99_RS01640	COG3447	MASE1 domain protein
B5J99_RS01655	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
B5J99_RS01680	COG0402	S-adenosylhomocysteine deaminase activity
B5J99_RS01685	COG0531	amino acid
B5J99_RS01700	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B5J99_RS01705	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B5J99_RS01720	COG1301	dicarboxylic acid transport
B5J99_RS01725	COG2188	Transcriptional regulator
B5J99_RS01735	COG0779	Required for maturation of 30S ribosomal subunits
B5J99_RS01750	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
B5J99_RS01755	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
B5J99_RS01770	COG1435	thymidine kinase activity
B5J99_RS01780	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
B5J99_RS01785	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
B5J99_RS01790	COG1185	polyribonucleotide nucleotidyltransferase activity
B5J99_RS01795	COG2852	Protein conserved in bacteria
B5J99_RS01805	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
B5J99_RS01810	COG2009	succinate dehydrogenase
B5J99_RS01825	COG2827	Endonuclease containing a URI domain
B5J99_RS01840	COG4941	Belongs to the sigma-70 factor family
B5J99_RS01845	COG3795	YCII-related domain
B5J99_RS01850	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
B5J99_RS01860	COG2853	Lipoprotein
B5J99_RS01870	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B5J99_RS01870	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
B5J99_RS01880	COG1372	Participates in initiation and elongation during chromosome replication
B5J99_RS01880	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B5J99_RS01905	COG0784	Response regulator, receiver
B5J99_RS01905	COG2198	Histidine kinase
B5J99_RS01905	COG2205	protein histidine kinase activity
B5J99_RS01915	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B5J99_RS01930	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
B5J99_RS01940	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
B5J99_RS01945	COG0142	geranyltranstransferase activity
B5J99_RS01950	COG1722	exodeoxyribonuclease VII activity
B5J99_RS01965	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B5J99_RS01980	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
B5J99_RS01985	COG0363	glucosamine-6-phosphate deaminase activity
B5J99_RS01990	COG0129	dihydroxy-acid dehydratase activity
B5J99_RS01995	COG0837	glucose binding
B5J99_RS02000	COG0800	Aldolase
B5J99_RS02010	COG0318	PFAM AMP-dependent synthetase and ligase
B5J99_RS02040	COG0492	ferredoxin-NADP+ reductase activity
B5J99_RS02045	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B5J99_RS02050	COG1755	Isoprenylcysteine carboxyl methyltransferase
B5J99_RS02060	COG0698	ribose 5-phosphate isomerase
B5J99_RS02065	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
B5J99_RS02075	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
B5J99_RS02090	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
B5J99_RS02100	COG0784	Response regulator, receiver
B5J99_RS02115	COG0343	queuine tRNA-ribosyltransferase activity
B5J99_RS02125	COG0805	protein transport
B5J99_RS02135	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B5J99_RS02140	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
B5J99_RS02145	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
B5J99_RS02150	COG1472	Belongs to the glycosyl hydrolase 3 family
B5J99_RS02160	COG0018	arginyl-trna synthetase
B5J99_RS02170	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
B5J99_RS02175	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
B5J99_RS02180	COG0328	RNA-DNA hybrid ribonuclease activity
B5J99_RS02185	COG3422	double-strand break repair
B5J99_RS02210	COG4964	Belongs to the GSP D family
B5J99_RS02240	COG4771	TonB-dependent receptor
B5J99_RS02245	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B5J99_RS02255	COG2336	PFAM SpoVT AbrB
B5J99_RS02260	COG2337	Toxic component of a toxin-antitoxin (TA) module
B5J99_RS02265	COG2066	Belongs to the glutaminase family
B5J99_RS02280	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
B5J99_RS02290	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
B5J99_RS02295	COG0849	cell division
B5J99_RS02300	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
B5J99_RS02305	COG1181	Belongs to the D-alanine--D-alanine ligase family
B5J99_RS02310	COG0812	UDP-N-acetylmuramate dehydrogenase activity
B5J99_RS02320	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
B5J99_RS02325	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B5J99_RS02335	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
B5J99_RS02340	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B5J99_RS02345	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
B5J99_RS02350	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
B5J99_RS02365	COG0275	rRNA processing
B5J99_RS02370	COG2001	Belongs to the MraZ family
B5J99_RS02390	COG0339	signal peptide processing
B5J99_RS02410	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B5J99_RS02470	COG0352	thiamine-phosphate diphosphorylase activity
B5J99_RS02490	COG0495	leucyl-tRNA aminoacylation
B5J99_RS02505	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B5J99_RS02525	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
B5J99_RS02535	COG0180	Tryptophanyl-tRNA synthetase
B5J99_RS02545	COG0756	dUTP diphosphatase activity
B5J99_RS02550	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
B5J99_RS02580	COG1012	belongs to the aldehyde dehydrogenase family
B5J99_RS02585	COG1648	precorrin-2 dehydrogenase activity
B5J99_RS02585	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
B5J99_RS02600	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B5J99_RS02610	COG0175	sulfate reduction
B5J99_RS02615	COG2200	EAL domain
B5J99_RS02625	COG1228	amidohydrolase
B5J99_RS02640	COG1028	Short-chain dehydrogenase reductase Sdr
B5J99_RS02660	COG1280	lysine exporter protein (LysE YggA)
B5J99_RS02670	COG2070	2-Nitropropane dioxygenase
B5J99_RS02675	COG0527	aspartate kinase activity
B5J99_RS02680	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
B5J99_RS02695	COG0305	Participates in initiation and elongation during chromosome replication
B5J99_RS02700	COG5328	Belongs to the UPF0262 family
B5J99_RS02715	COG0717	Belongs to the dCTP deaminase family
B5J99_RS02720	COG3268	Saccharopine dehydrogenase
B5J99_RS02725	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
B5J99_RS02730	COG2234	aminopeptidase activity
B5J99_RS02735	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B5J99_RS02740	COG3047	cAMP biosynthetic process
B5J99_RS02760	COG2010	Cytochrome c
B5J99_RS02790	COG5001	Diguanylate cyclase
B5J99_RS02795	COG0635	Involved in the biosynthesis of porphyrin-containing compound
B5J99_RS02800	COG1335	isochorismatase
B5J99_RS02805	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B5J99_RS02810	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
B5J99_RS02820	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B5J99_RS02825	COG1802	Transcriptional regulator
B5J99_RS02845	COG4771	TonB-dependent receptor
B5J99_RS02850	COG2363	Small membrane protein
B5J99_RS02855	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
B5J99_RS02870	COG2204	response regulator
B5J99_RS02880	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
B5J99_RS02910	COG1592	Rubrerythrin
B5J99_RS02915	COG0776	regulation of translation
B5J99_RS02920	COG1674	ftsk spoiiie
B5J99_RS02925	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B5J99_RS02930	COG0354	folic acid binding
B5J99_RS02950	COG0697	spore germination
B5J99_RS02975	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
B5J99_RS02995	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
B5J99_RS03000	COG0072	phenylalanine-tRNA ligase activity
B5J99_RS03010	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
B5J99_RS03015	COG0483	inositol monophosphate 1-phosphatase activity
B5J99_RS03040	COG2226	methyltransferase
B5J99_RS03050	COG1609	Transcriptional regulator
B5J99_RS03060	COG1770	oligopeptidase
B5J99_RS03065	COG3279	Response regulator of the LytR AlgR family
B5J99_RS03080	COG3713	MltA-interacting MipA family protein
B5J99_RS03105	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
B5J99_RS03175	COG0508	dehydrogenase complex catalyzes the overall conversion of
B5J99_RS03180	COG0022	dehydrogenase e1 component
B5J99_RS03185	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
B5J99_RS03195	COG1028	Short-chain dehydrogenase reductase Sdr
B5J99_RS03220	COG0824	Thioesterase
B5J99_RS03240	COG1983	PspC domain protein
B5J99_RS03245	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
B5J99_RS03260	COG0210	DNA helicase
B5J99_RS03270	COG0525	valine-tRNA ligase activity
B5J99_RS03275	COG0823	Involved in the tonB-independent uptake of proteins
B5J99_RS03275	COG1506	peptidase
B5J99_RS03290	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
B5J99_RS03310	COG1671	Belongs to the UPF0178 family
B5J99_RS03345	COG0783	Belongs to the Dps family
B5J99_RS03385	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
B5J99_RS03390	COG3483	tryptophan 2,3-dioxygenase activity
B5J99_RS03405	COG0640	Transcriptional regulator
B5J99_RS03420	COG1410	methionine synthase
B5J99_RS03420	COG0646	methionine synthase
B5J99_RS03425	COG0475	glutathione-regulated potassium exporter activity
B5J99_RS03435	COG1253	flavin adenine dinucleotide binding
B5J99_RS03445	COG1448	Aminotransferase
B5J99_RS03465	COG4771	TonB-dependent receptor
B5J99_RS03475	COG4166	transmembrane transport
B5J99_RS03485	COG4172	Belongs to the ABC transporter superfamily
B5J99_RS03490	COG0444	Belongs to the ABC transporter superfamily
B5J99_RS03495	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B5J99_RS03500	COG0601	transmembrane transport
B5J99_RS03530	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
B5J99_RS03540	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B5J99_RS03565	COG1595	DNA-templated transcription, initiation
B5J99_RS03580	COG2203	Gaf domain
B5J99_RS03580	COG3706	GGDEF domain
B5J99_RS03580	COG4251	negative regulation of phosphorylation
B5J99_RS03580	COG5001	Diguanylate cyclase
B5J99_RS03610	COG1278	Cold shock
B5J99_RS03640	COG2010	Cytochrome c
B5J99_RS03640	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
B5J99_RS03645	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
B5J99_RS03660	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
B5J99_RS03665	COG0657	acetylesterase activity
B5J99_RS03680	COG4771	TonB-dependent receptor
B5J99_RS03690	COG1609	Transcriptional regulator
B5J99_RS03730	COG1392	Phosphate transport regulator
B5J99_RS03735	COG0306	phosphate transporter
B5J99_RS03745	COG4206	TonB-dependent receptor
B5J99_RS03765	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B5J99_RS03770	COG1120	ATPase activity
B5J99_RS03775	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
B5J99_RS03780	COG1492	cobalamin metabolic process
B5J99_RS03785	COG0778	Nitroreductase
B5J99_RS03790	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
B5J99_RS03795	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
B5J99_RS03810	COG2223	nitrite transmembrane transporter activity
B5J99_RS03820	COG1902	pentaerythritol trinitrate reductase activity
B5J99_RS03855	COG1684	flagellar biosynthetic protein fliR
B5J99_RS03860	COG1987	bacterial-type flagellum assembly
B5J99_RS03900	COG1157	protein secretion by the type III secretion system
B5J99_RS03910	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
B5J99_RS03920	COG1677	Flagellar hook-basal body complex protein FliE
B5J99_RS03925	COG2204	response regulator
B5J99_RS03930	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
B5J99_RS03935	COG1191	sigma factor activity
B5J99_RS03970	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
B5J99_RS03980	COG1558	bacterial-type flagellum-dependent cell motility
B5J99_RS03990	COG4786	Flagellar basal body rod
B5J99_RS04000	COG4786	Flagellar basal body rod
B5J99_RS04005	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
B5J99_RS04010	COG1706	bacterial-type flagellum-dependent cell motility
B5J99_RS04030	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
B5J99_RS04035	COG1360	Flagellar Motor Protein
B5J99_RS04055	COG1960	acyl-CoA dehydrogenase activity
B5J99_RS04060	COG0009	L-threonylcarbamoyladenylate synthase
B5J99_RS04065	COG0308	aminopeptidase N
B5J99_RS04075	COG0471	metal ion transport
B5J99_RS04085	COG0438	transferase activity, transferring glycosyl groups
B5J99_RS04085	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B5J99_RS04090	COG1253	flavin adenine dinucleotide binding
B5J99_RS04095	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
B5J99_RS04100	COG1702	phosphate starvation-inducible protein PhoH
B5J99_RS04105	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B5J99_RS04120	COG4957	zinc ion binding
B5J99_RS04135	COG0778	Nitroreductase
B5J99_RS04140	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
B5J99_RS04145	COG0612	Peptidase, M16
B5J99_RS04160	COG0544	peptidyl-prolyl cis-trans isomerase activity
B5J99_RS04165	COG0740	serine-type endopeptidase activity
B5J99_RS04170	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
B5J99_RS04180	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
B5J99_RS04195	COG0596	Alpha beta hydrolase
B5J99_RS04205	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
B5J99_RS04210	COG0318	PFAM AMP-dependent synthetase and ligase
B5J99_RS04215	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
B5J99_RS04225	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
B5J99_RS04230	COG1960	acyl-CoA dehydrogenase activity
B5J99_RS04265	COG1999	signal sequence binding
B5J99_RS04270	COG2983	Belongs to the UPF0260 family
B5J99_RS04285	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
B5J99_RS04290	COG1028	Short-chain dehydrogenase reductase Sdr
B5J99_RS04295	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B5J99_RS04315	COG1131	(ABC) transporter
B5J99_RS04320	COG1329	Transcriptional regulator
B5J99_RS04325	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
B5J99_RS04340	COG0739	heme binding
B5J99_RS04350	COG2226	methyltransferase
B5J99_RS04370	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
B5J99_RS04395	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
B5J99_RS04400	COG0511	ligase activity, forming carbon-carbon bonds
B5J99_RS04405	COG0439	Biotin carboxylase
B5J99_RS04430	COG2258	MOSC domain
B5J99_RS04450	COG0156	8-amino-7-oxononanoate synthase activity
B5J99_RS04460	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
B5J99_RS04495	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
B5J99_RS04500	COG1429	ligase activity, forming nitrogen-metal bonds
B5J99_RS04510	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
B5J99_RS04535	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
B5J99_RS04540	COG2211	Major facilitator Superfamily
B5J99_RS04545	COG0644	oxidoreductase
B5J99_RS04585	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
B5J99_RS04595	COG2130	NADP-dependent
B5J99_RS04610	COG4771	TonB-dependent receptor
B5J99_RS04615	COG3383	formate dehydrogenase (NAD+) activity
B5J99_RS04635	COG2130	NADP-dependent
B5J99_RS04640	COG1028	Short-chain dehydrogenase reductase Sdr
B5J99_RS04650	COG3609	addiction module antidote protein, CC2985 family
B5J99_RS04660	COG1960	acyl-CoA dehydrogenase activity
B5J99_RS04670	COG0183	Belongs to the thiolase family
B5J99_RS04685	COG1960	acyl-CoA dehydrogenase activity
B5J99_RS04690	COG1028	Short-chain dehydrogenase reductase Sdr
B5J99_RS04705	COG4638	Rieske (2fe-2S)
B5J99_RS04725	COG1028	Short-chain dehydrogenase reductase Sdr
B5J99_RS04770	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B5J99_RS04775	COG1210	Utp--glucose-1-phosphate uridylyltransferase
B5J99_RS04785	COG3743	rRNA binding
B5J99_RS04785	COG0261	This protein binds to 23S rRNA in the presence of protein L20
B5J99_RS04790	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
B5J99_RS04795	COG0815	Transfers the fatty acyl group on membrane lipoproteins
B5J99_RS04830	COG1968	undecaprenyl-diphosphatase activity
B5J99_RS04835	COG2015	COG2015, Alkyl sulfatase and related hydrolases
B5J99_RS04845	COG0218	Necessary for normal cell division and for the maintenance of normal septation
B5J99_RS04850	COG0706	membrane insertase activity
B5J99_RS04855	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
B5J99_RS04860	COG0594	ribonuclease P activity
B5J99_RS04865	COG0230	Belongs to the bacterial ribosomal protein bL34 family
B5J99_RS04880	COG0312	modulator of DNA gyrase
B5J99_RS04885	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B5J99_RS04885	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
B5J99_RS04905	COG2162	N-hydroxyarylamine O-acetyltransferase activity
B5J99_RS04930	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B5J99_RS04945	COG5265	(ABC) transporter
B5J99_RS04955	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
B5J99_RS04960	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
B5J99_RS04960	COG2813	Specifically methylates the guanine in position
B5J99_RS04965	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
B5J99_RS04980	COG0408	coproporphyrinogen oxidase activity
B5J99_RS04985	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
B5J99_RS05020	COG4771	TonB-dependent receptor
B5J99_RS05035	COG1116	anion transmembrane transporter activity
B5J99_RS05040	COG0864	Transcriptional regulator
B5J99_RS05080	COG0457	Tetratricopeptide repeat
B5J99_RS05105	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
B5J99_RS05110	COG0463	Glycosyl transferase, family 2
B5J99_RS05120	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
B5J99_RS05135	COG4957	zinc ion binding
B5J99_RS05140	COG0586	Pfam SNARE associated Golgi protein
B5J99_RS05145	COG1028	Short-chain dehydrogenase reductase Sdr
B5J99_RS05150	COG0277	FAD linked oxidase domain protein
B5J99_RS05160	COG0546	phosphoglycolate phosphatase activity
B5J99_RS05160	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
B5J99_RS05170	COG0220	tRNA (guanine-N7-)-methyltransferase activity
B5J99_RS05175	COG0318	PFAM AMP-dependent synthetase and ligase
B5J99_RS05185	COG0312	modulator of DNA gyrase
B5J99_RS05195	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
B5J99_RS05200	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
B5J99_RS05205	COG0583	DNA-binding transcription factor activity
B5J99_RS05215	COG0281	malic enzyme
B5J99_RS05215	COG0280	phosphate acetyltransferase
B5J99_RS05220	COG1024	Enoyl-CoA hydratase
B5J99_RS05240	COG1238	metal cluster binding
B5J99_RS05280	COG2132	Multicopper oxidase
B5J99_RS05285	COG1937	Protein conserved in bacteria
B5J99_RS05310	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
B5J99_RS05335	COG1309	transcriptional regulator
B5J99_RS05385	COG2267	carboxylic ester hydrolase activity
B5J99_RS05400	COG1028	Short-chain dehydrogenase reductase Sdr
B5J99_RS05410	COG4771	TonB-dependent receptor
B5J99_RS05415	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
B5J99_RS05425	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B5J99_RS05445	COG1028	Short-chain dehydrogenase reductase Sdr
B5J99_RS05465	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B5J99_RS05470	COG5001	Diguanylate cyclase
B5J99_RS05510	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B5J99_RS05520	COG0753	catalase activity
B5J99_RS05530	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B5J99_RS05545	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
B5J99_RS05560	COG1335	isochorismatase
B5J99_RS05630	COG4771	TonB-dependent receptor
B5J99_RS05650	COG2301	Belongs to the HpcH HpaI aldolase family
B5J99_RS05655	COG2030	dehydratase
B5J99_RS05665	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B5J99_RS05675	COG2188	Transcriptional regulator
B5J99_RS05695	COG0154	amidase activity
B5J99_RS05715	COG1024	Enoyl-CoA hydratase
B5J99_RS05765	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
B5J99_RS05795	COG1086	Polysaccharide biosynthesis protein
B5J99_RS05830	COG3547	Transposase (IS116 IS110 IS902 family)
B5J99_RS05855	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
B5J99_RS05875	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
B5J99_RS05910	COG1028	Short-chain dehydrogenase reductase Sdr
B5J99_RS05915	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B5J99_RS05925	COG1482	cell wall glycoprotein biosynthetic process
B5J99_RS05960	COG0181	hydroxymethylbilane synthase activity
B5J99_RS05965	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
B5J99_RS05970	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
B5J99_RS05980	COG1607	acyl-coa hydrolase
B5J99_RS05990	COG0517	IMP dehydrogenase activity
B5J99_RS05995	COG0433	COG0433 Predicted ATPase
B5J99_RS06000	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
B5J99_RS06010	COG0489	protein tyrosine kinase activity
B5J99_RS06015	COG0330	HflC and HflK could
B5J99_RS06030	COG1028	Short-chain dehydrogenase reductase Sdr
B5J99_RS06040	COG4152	abc transporter atp-binding protein
B5J99_RS06045	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
B5J99_RS06055	COG2171	N-acyltransferase activity
B5J99_RS06060	COG0222	ribosome binding
B5J99_RS06065	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
B5J99_RS06080	COG0081	regulation of translation
B5J99_RS06085	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
B5J99_RS06090	COG0250	Participates in transcription elongation, termination and antitermination
B5J99_RS06095	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
B5J99_RS06105	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
B5J99_RS06110	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
B5J99_RS06120	COG1324	tolerance protein
B5J99_RS06125	COG1612	heme a metabolic process
B5J99_RS06135	COG2022	thiamine diphosphate biosynthetic process
B5J99_RS06170	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
B5J99_RS06175	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
B5J99_RS06180	COG0237	dephospho-CoA kinase activity
B5J99_RS06185	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
B5J99_RS06190	COG0424	maF-like protein
B5J99_RS06195	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
B5J99_RS06200	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
B5J99_RS06210	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
B5J99_RS06215	COG0861	Integral membrane protein TerC family
B5J99_RS06250	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
B5J99_RS06255	COG0445	tRNA wobble uridine modification
B5J99_RS06260	COG0357	Ribosomal RNA small subunit methyltransferase G
B5J99_RS06290	COG2884	Cell division ATP-binding protein ftsE
B5J99_RS06325	COG1877	trehalose-phosphatase activity
B5J99_RS06330	COG3387	PFAM Glycoside hydrolase 15-related
B5J99_RS06350	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
B5J99_RS06355	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
B5J99_RS06370	COG1054	Belongs to the UPF0176 family
B5J99_RS06380	COG4771	TonB-dependent receptor
B5J99_RS06390	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
B5J99_RS06395	COG0248	Ppx GppA phosphatase
B5J99_RS06410	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
B5J99_RS06420	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
B5J99_RS06425	COG4771	TonB-dependent receptor
B5J99_RS06470	COG1414	Transcriptional regulator
B5J99_RS06475	COG1012	belongs to the aldehyde dehydrogenase family
B5J99_RS06480	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B5J99_RS06490	COG0277	FAD linked oxidase domain protein
B5J99_RS06495	COG1012	belongs to the aldehyde dehydrogenase family
B5J99_RS06505	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
B5J99_RS06525	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B5J99_RS06575	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
B5J99_RS06590	COG0457	Tetratricopeptide repeat
B5J99_RS06605	COG0438	transferase activity, transferring glycosyl groups
B5J99_RS06620	COG1063	alcohol dehydrogenase
B5J99_RS06645	COG3275	phosphorelay sensor kinase activity
B5J99_RS06650	COG0405	Gamma-glutamyltransferase
B5J99_RS06660	COG0167	dihydroorotate dehydrogenase activity
B5J99_RS06690	COG2759	Belongs to the formate--tetrahydrofolate ligase family
B5J99_RS06695	COG2885	chlorophyll binding
B5J99_RS06700	COG1253	flavin adenine dinucleotide binding
B5J99_RS06725	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
B5J99_RS06730	COG0291	Belongs to the bacterial ribosomal protein bL35 family
B5J99_RS06755	COG0670	Belongs to the BI1 family
B5J99_RS06785	COG0267	Belongs to the bacterial ribosomal protein bL33 family
B5J99_RS06810	COG4974	Belongs to the 'phage' integrase family
B5J99_RS06815	COG0517	IMP dehydrogenase activity
B5J99_RS06820	COG2095	MarC family integral membrane protein
B5J99_RS06830	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
B5J99_RS06840	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
B5J99_RS06860	COG0347	Belongs to the P(II) protein family
B5J99_RS06865	COG0004	ammonium transporteR
B5J99_RS06875	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B5J99_RS06880	COG0513	Belongs to the DEAD box helicase family
B5J99_RS06925	COG1959	2 iron, 2 sulfur cluster binding
B5J99_RS06930	COG0719	Fe-S assembly protein
B5J99_RS06945	COG0396	ATPase activity
B5J99_RS06955	COG0719	Fe-S assembly protein
B5J99_RS06960	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
B5J99_RS06965	COG2151	metal-sulfur cluster biosynthetic enzyme
B5J99_RS06970	COG0316	Belongs to the HesB IscA family
B5J99_RS06985	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B5J99_RS06985	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B5J99_RS07010	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B5J99_RS07015	COG0287	Prephenate dehydrogenase
B5J99_RS07030	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
B5J99_RS07035	COG1127	ABC transporter
B5J99_RS07050	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
B5J99_RS07070	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
B5J99_RS07105	COG4191	Histidine kinase
B5J99_RS07105	COG0784	Response regulator, receiver
B5J99_RS07120	COG0318	PFAM AMP-dependent synthetase and ligase
B5J99_RS07145	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B5J99_RS07150	COG1414	Transcriptional regulator
B5J99_RS07155	COG4771	TonB-dependent receptor
B5J99_RS07160	COG0655	NAD(P)H dehydrogenase (quinone) activity
B5J99_RS07175	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
B5J99_RS07180	COG0784	Response regulator, receiver
B5J99_RS07180	COG4191	Histidine kinase
B5J99_RS07195	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B5J99_RS07205	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
B5J99_RS07220	COG2824	Alkylphosphonate utilization operon protein PhnA
B5J99_RS07235	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
B5J99_RS07240	COG1794	racemase activity, acting on amino acids and derivatives
B5J99_RS07245	COG0501	Belongs to the peptidase M48B family
B5J99_RS07250	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
B5J99_RS07270	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
B5J99_RS07275	COG0268	Binds directly to 16S ribosomal RNA
B5J99_RS07280	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
B5J99_RS07285	COG2226	methyltransferase
B5J99_RS07290	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
B5J99_RS07300	COG0640	Transcriptional regulator
B5J99_RS07305	COG1902	pentaerythritol trinitrate reductase activity
B5J99_RS07325	COG0085	RNA polymerase activity
B5J99_RS07330	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
B5J99_RS07345	COG0655	NAD(P)H dehydrogenase (quinone) activity
B5J99_RS07355	COG0583	DNA-binding transcription factor activity
B5J99_RS07365	COG0477	Major facilitator Superfamily
B5J99_RS07380	COG0742	ribosomal rna small subunit methyltransferase
B5J99_RS07385	COG1187	pseudouridine synthase activity
B5J99_RS07400	COG2271	Major facilitator Superfamily
B5J99_RS07420	COG1028	Short-chain dehydrogenase reductase Sdr
B5J99_RS07430	COG2272	Belongs to the type-B carboxylesterase lipase family
B5J99_RS07445	COG4771	TonB-dependent receptor
B5J99_RS07455	COG3507	Belongs to the glycosyl hydrolase 43 family
B5J99_RS07460	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
B5J99_RS07470	COG0284	orotidine-5'-phosphate decarboxylase activity
B5J99_RS07475	COG0135	phosphoribosylanthranilate isomerase activity
B5J99_RS07480	COG0133	tryptophan synthase activity
B5J99_RS07485	COG0159	tryptophan synthase activity
B5J99_RS07490	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
B5J99_RS07495	COG0285	dihydrofolate synthase activity
B5J99_RS07500	COG1960	acyl-CoA dehydrogenase activity
B5J99_RS07505	COG1960	acyl-CoA dehydrogenase activity
B5J99_RS07510	COG0492	ferredoxin-NADP+ reductase activity
B5J99_RS07515	COG1024	Enoyl-CoA hydratase
B5J99_RS07555	COG1215	transferase activity, transferring glycosyl groups
B5J99_RS07565	COG0730	response to heat
B5J99_RS07580	COG0602	queuosine metabolic process
B5J99_RS07615	COG2885	chlorophyll binding
B5J99_RS07615	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
B5J99_RS07625	COG5487	UPF0391 membrane protein
B5J99_RS07630	COG0628	permease
B5J99_RS07635	COG1674	ftsk spoiiie
B5J99_RS07640	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B5J99_RS07645	COG1309	transcriptional regulator
B5J99_RS07650	COG4771	TonB-dependent receptor
B5J99_RS07655	COG0601	transmembrane transport
B5J99_RS07675	COG0789	Transcriptional regulator
B5J99_RS07690	COG1918	ferrous iron import across plasma membrane
B5J99_RS07690	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
B5J99_RS07695	COG0629	single-stranded DNA binding
B5J99_RS07705	COG4689	acetoacetate decarboxylase
B5J99_RS07720	COG1028	Short-chain dehydrogenase reductase Sdr
B5J99_RS07750	COG5507	3-demethylubiquinone-9 3-methyltransferase
B5J99_RS07775	COG0625	glutathione transferase activity
B5J99_RS07780	COG1940	carbohydrate kinase activity
B5J99_RS07785	COG1621	beta-fructofuranosidase activity
B5J99_RS07800	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
B5J99_RS07835	COG1278	Cold shock
B5J99_RS07840	COG1253	flavin adenine dinucleotide binding
B5J99_RS07860	COG1137	ATPase activity
B5J99_RS07865	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
B5J99_RS07895	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
B5J99_RS07900	COG4221	oxidoreductase activity
B5J99_RS07915	COG0583	DNA-binding transcription factor activity
B5J99_RS07920	COG0686	Belongs to the AlaDH PNT family
B5J99_RS07940	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B5J99_RS07945	COG4771	TonB-dependent receptor
B5J99_RS07960	COG1131	(ABC) transporter
B5J99_RS07975	COG3631	Ketosteroid isomerase-related protein
B5J99_RS07980	COG0702	epimerase
B5J99_RS07995	COG0583	DNA-binding transcription factor activity
B5J99_RS08015	COG0024	Methionine aminopeptidase
B5J99_RS08045	COG2249	NAD(P)H dehydrogenase (quinone) activity
B5J99_RS08055	COG2207	Transcriptional regulator
B5J99_RS08060	COG4221	oxidoreductase activity
B5J99_RS08065	COG0667	Aldo Keto reductase
B5J99_RS08085	COG2814	Major facilitator Superfamily
B5J99_RS08095	COG1024	Enoyl-CoA hydratase
B5J99_RS08115	COG0583	DNA-binding transcription factor activity
B5J99_RS08125	COG4638	Rieske (2fe-2S)
B5J99_RS08130	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
B5J99_RS08155	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B5J99_RS08170	COG2936	dipeptidyl-peptidase activity
B5J99_RS08225	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
B5J99_RS08230	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
B5J99_RS08240	COG1012	belongs to the aldehyde dehydrogenase family
B5J99_RS08275	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B5J99_RS08310	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B5J99_RS08320	COG4771	TonB-dependent receptor
B5J99_RS08330	COG3618	amidohydrolase
B5J99_RS08340	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
B5J99_RS08355	COG2159	amidohydrolase
B5J99_RS08375	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B5J99_RS08385	COG0745	RESPONSE REGULATOR receiver
B5J99_RS08405	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
B5J99_RS08425	COG1064	alcohol dehydrogenase
B5J99_RS08440	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B5J99_RS08445	COG2271	Major facilitator Superfamily
B5J99_RS08455	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B5J99_RS08460	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
B5J99_RS08465	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B5J99_RS08485	COG4452	Inner membrane protein CreD
B5J99_RS08500	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
B5J99_RS08505	COG0508	dehydrogenase complex catalyzes the overall conversion of
B5J99_RS08505	COG0596	Alpha beta hydrolase
B5J99_RS08510	COG0500	methyltransferase
B5J99_RS08515	COG1063	alcohol dehydrogenase
B5J99_RS08520	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
B5J99_RS08525	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
B5J99_RS08530	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
B5J99_RS08570	COG1473	amidohydrolase
B5J99_RS08590	COG0556	nucleotide-excision repair
B5J99_RS08605	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
B5J99_RS08650	COG1194	a g-specific adenine glycosylase
B5J99_RS08660	COG2816	NAD+ diphosphatase activity
B5J99_RS08670	COG0582	viral genome integration into host DNA
B5J99_RS08695	COG1028	Short-chain dehydrogenase reductase Sdr
B5J99_RS08705	COG1028	Short-chain dehydrogenase reductase Sdr
B5J99_RS08710	COG4974	Belongs to the 'phage' integrase family
B5J99_RS08715	COG0517	IMP dehydrogenase activity
B5J99_RS08735	COG3214	Protein conserved in bacteria
B5J99_RS08750	COG2072	flavoprotein involved in K transport
B5J99_RS08790	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
B5J99_RS08815	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
B5J99_RS08830	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
B5J99_RS08835	COG0539	negative regulation of cytoplasmic translation
B5J99_RS08850	COG2199	diguanylate cyclase activity
B5J99_RS08865	COG4106	trans-aconitate 2-methyltransferase activity
B5J99_RS08905	COG2264	protein methyltransferase activity
B5J99_RS08915	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B5J99_RS08925	COG2096	Adenosyltransferase
B5J99_RS08930	COG1262	PFAM Formylglycine-generating sulfatase enzyme
B5J99_RS08935	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
B5J99_RS08940	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B5J99_RS08945	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
B5J99_RS08960	COG1192	Involved in chromosome partitioning
B5J99_RS08970	COG4774	siderophore transport
B5J99_RS09000	COG0657	acetylesterase activity
B5J99_RS09030	COG1984	allophanate hydrolase subunit 2
B5J99_RS09045	COG1914	H( )-stimulated, divalent metal cation uptake system
B5J99_RS09065	COG3156	type II secretion system protein K
B5J99_RS09080	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B5J99_RS09085	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
B5J99_RS09090	COG1138	Cytochrome C-type biogenesis protein
B5J99_RS09100	COG3088	subunit of a heme lyase
B5J99_RS09110	COG3158	transport of potassium into the cell
B5J99_RS09130	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B5J99_RS09140	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B5J99_RS09145	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
B5J99_RS09150	COG0156	8-amino-7-oxononanoate synthase activity
B5J99_RS09155	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
B5J99_RS09160	COG0440	acetolactate synthase activity
B5J99_RS09165	COG0028	Belongs to the TPP enzyme family
B5J99_RS09170	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
B5J99_RS09175	COG3830	Belongs to the UPF0237 family
B5J99_RS09175	COG0560	Phosphoserine phosphatase
B5J99_RS09180	COG1028	Short-chain dehydrogenase reductase Sdr
B5J99_RS09185	COG0745	RESPONSE REGULATOR receiver
B5J99_RS09190	COG0704	Plays a role in the regulation of phosphate uptake
B5J99_RS09195	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
B5J99_RS09205	COG0573	inorganic phosphate transmembrane transporter activity
B5J99_RS09215	COG5002	protein histidine kinase activity
B5J99_RS09240	COG0546	phosphoglycolate phosphatase activity
B5J99_RS09245	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
B5J99_RS09260	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B5J99_RS09270	COG5001	Diguanylate cyclase
B5J99_RS09270	COG1716	ATPase activity
B5J99_RS09275	COG0047	phosphoribosylformylglycinamidine synthase activity
B5J99_RS09285	COG0612	Peptidase, M16
B5J99_RS09290	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
B5J99_RS09295	COG1024	Enoyl-CoA hydratase
B5J99_RS09300	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
B5J99_RS09305	COG5001	Diguanylate cyclase
B5J99_RS09310	COG0617	tRNA 3'-terminal CCA addition
B5J99_RS09340	COG2032	superoxide dismutase activity
B5J99_RS09365	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
B5J99_RS09370	COG1695	Transcriptional regulator
B5J99_RS09380	COG0156	8-amino-7-oxononanoate synthase activity
B5J99_RS09400	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
B5J99_RS09405	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
B5J99_RS09410	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
B5J99_RS09415	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
B5J99_RS09430	COG2119	membrane
B5J99_RS09440	COG0137	argininosuccinate synthase activity
B5J99_RS09470	COG2885	chlorophyll binding
B5J99_RS09475	COG0823	Involved in the tonB-independent uptake of proteins
B5J99_RS09495	COG0824	Thioesterase
B5J99_RS09500	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
B5J99_RS09515	COG2205	protein histidine kinase activity
B5J99_RS09525	COG0745	RESPONSE REGULATOR receiver
B5J99_RS09530	COG1012	belongs to the aldehyde dehydrogenase family
B5J99_RS09540	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
B5J99_RS09550	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
B5J99_RS09565	COG1181	Belongs to the D-alanine--D-alanine ligase family
B5J99_RS09575	COG1530	ribonuclease E activity
B5J99_RS09580	COG0860	N-Acetylmuramoyl-L-alanine amidase
B5J99_RS09585	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
B5J99_RS09590	COG1959	2 iron, 2 sulfur cluster binding
B5J99_RS09595	COG3920	Histidine kinase
B5J99_RS09605	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
B5J99_RS09625	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
B5J99_RS09630	COG2111	Na H antiporter
B5J99_RS09630	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
B5J99_RS09635	COG1006	Multisubunit Na H antiporter MnhC subunit
B5J99_RS09640	COG0651	ATP synthesis coupled electron transport
B5J99_RS09645	COG1863	multisubunit Na H antiporter MnhE subunit
B5J99_RS09650	COG2212	antiporter activity
B5J99_RS09675	COG0436	Aminotransferase
B5J99_RS09680	COG0471	metal ion transport
B5J99_RS09680	COG3273	potassium ion transport
B5J99_RS09685	COG2198	Histidine kinase
B5J99_RS09685	COG0784	Response regulator, receiver
B5J99_RS09685	COG2205	protein histidine kinase activity
B5J99_RS09690	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
B5J99_RS09700	COG2202	Pas domain
B5J99_RS09700	COG2205	protein histidine kinase activity
B5J99_RS09705	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B5J99_RS09710	COG1012	belongs to the aldehyde dehydrogenase family
B5J99_RS09720	COG4774	siderophore transport
B5J99_RS09730	COG0246	Mannitol dehydrogenase
B5J99_RS09735	COG1904	glucuronate isomerase
B5J99_RS09785	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B5J99_RS09790	COG1846	Transcriptional regulator
B5J99_RS09795	COG2130	NADP-dependent
B5J99_RS09800	COG1024	Enoyl-CoA hydratase
B5J99_RS09805	COG1960	acyl-CoA dehydrogenase activity
B5J99_RS09820	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
B5J99_RS09835	COG0066	3-isopropylmalate dehydratase activity
B5J99_RS09855	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
B5J99_RS09860	COG2962	Rard protein
B5J99_RS09880	COG0484	heat shock protein binding
B5J99_RS09895	COG3023	N-Acetylmuramoyl-L-alanine amidase
B5J99_RS09905	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
B5J99_RS09910	COG2201	protein-glutamate methylesterase activity
B5J99_RS09925	COG0643	Histidine kinase
B5J99_RS09925	COG2198	Histidine kinase
B5J99_RS09940	COG0564	pseudouridine synthase activity
B5J99_RS09945	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
B5J99_RS09960	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
B5J99_RS09970	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
B5J99_RS09990	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B5J99_RS10010	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
B5J99_RS10015	COG4206	TonB-dependent receptor
B5J99_RS10020	COG4221	oxidoreductase activity
B5J99_RS10025	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
B5J99_RS10030	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
B5J99_RS10045	COG1960	acyl-CoA dehydrogenase activity
B5J99_RS10080	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B5J99_RS10085	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
B5J99_RS10090	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
B5J99_RS10110	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
B5J99_RS10110	COG0456	acetyltransferase
B5J99_RS10115	COG1611	Belongs to the LOG family
B5J99_RS10125	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
B5J99_RS10140	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B5J99_RS10165	COG0542	response to heat
B5J99_RS10175	COG2308	Evidence 4 Homologs of previously reported genes of
B5J99_RS10240	COG3104	oligopeptide transport
B5J99_RS10245	COG0402	S-adenosylhomocysteine deaminase activity
B5J99_RS10250	COG1228	amidohydrolase
B5J99_RS10260	COG0667	Aldo Keto reductase
B5J99_RS10270	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B5J99_RS10275	COG3813	Protein conserved in bacteria
B5J99_RS10280	COG0351	phosphomethylpyrimidine kinase
B5J99_RS10280	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
B5J99_RS10280	COG0352	thiamine-phosphate diphosphorylase activity
B5J99_RS10295	COG2917	probably involved in intracellular septation
B5J99_RS10300	COG0552	protein localization to endoplasmic reticulum
B5J99_RS10305	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B5J99_RS10310	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
B5J99_RS10320	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
B5J99_RS10325	COG0228	four-way junction DNA binding
B5J99_RS10330	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
B5J99_RS10345	COG0336	Belongs to the RNA methyltransferase TrmD family
B5J99_RS10350	COG0335	large ribosomal subunit rRNA binding
B5J99_RS10355	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
B5J99_RS10360	COG2814	Major facilitator Superfamily
B5J99_RS10365	COG1566	PFAM secretion protein HlyD family protein
B5J99_RS10395	COG0659	secondary active sulfate transmembrane transporter activity
B5J99_RS10405	COG0640	Transcriptional regulator
B5J99_RS10410	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
B5J99_RS10420	COG0359	binds to the 23S rRNA
B5J99_RS10425	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
B5J99_RS10430	COG0360	Binds together with S18 to 16S ribosomal RNA
B5J99_RS10435	COG2199	diguanylate cyclase activity
B5J99_RS10445	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
B5J99_RS10455	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B5J99_RS10460	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B5J99_RS10465	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
B5J99_RS10495	COG1262	PFAM Formylglycine-generating sulfatase enzyme
B5J99_RS10520	COG1252	NADH dehydrogenase
B5J99_RS10580	COG3701	Conjugal transfer protein
B5J99_RS10600	COG3451	type IV secretory pathway VirB4
B5J99_RS10615	COG4962	Type ii secretion system protein e
B5J99_RS10635	COG0741	lytic transglycosylase activity
B5J99_RS10695	COG5489	Protein of unknown function (DUF736)
B5J99_RS10740	COG0686	Belongs to the AlaDH PNT family
B5J99_RS10770	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B5J99_RS10775	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B5J99_RS10785	COG0513	Belongs to the DEAD box helicase family
B5J99_RS10800	COG2081	HI0933 family
B5J99_RS10805	COG2003	Belongs to the UPF0758 family
B5J99_RS10830	COG0356	it plays a direct role in the translocation of protons across the membrane
B5J99_RS10840	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
B5J99_RS10845	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
B5J99_RS10850	COG0322	excinuclease ABC activity
B5J99_RS10855	COG1381	Involved in DNA repair and RecF pathway recombination
B5J99_RS10860	COG0473	3-isopropylmalate dehydrogenase activity
B5J99_RS10865	COG0151	Belongs to the GarS family
B5J99_RS10870	COG1570	exodeoxyribonuclease VII activity
B5J99_RS10920	COG2255	four-way junction helicase activity
B5J99_RS10935	COG0632	four-way junction helicase activity
B5J99_RS10940	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
B5J99_RS10950	COG0217	transcriptional regulatory protein
B5J99_RS10960	COG3750	Belongs to the UPF0335 family
B5J99_RS10970	COG0469	pyruvate kinase activity
B5J99_RS10980	COG0257	Belongs to the bacterial ribosomal protein bL36 family
B5J99_RS10990	COG2866	Carboxypeptidase
B5J99_RS11000	COG1301	dicarboxylic acid transport
B5J99_RS11005	COG0471	metal ion transport
B5J99_RS11005	COG3273	potassium ion transport
B5J99_RS11010	COG2814	Major facilitator Superfamily
B5J99_RS11015	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
B5J99_RS11030	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
B5J99_RS11035	COG1295	ribonuclease BN
B5J99_RS11040	COG0484	heat shock protein binding
B5J99_RS11050	COG0259	pyridoxamine-phosphate oxidase activity
B5J99_RS11080	COG0482	sulfurtransferase activity
B5J99_RS11100	COG2890	protein-(glutamine-N5) methyltransferase activity
B5J99_RS11105	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
B5J99_RS11110	COG0124	histidyl-tRNA synthetase
B5J99_RS11120	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
B5J99_RS11130	COG0045	succinate-CoA ligase (ADP-forming) activity
B5J99_RS11135	COG2086	electron transfer activity
B5J99_RS11145	COG0138	bifunctional purine biosynthesis protein purh
B5J99_RS11155	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
B5J99_RS11160	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B5J99_RS11160	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
B5J99_RS11165	COG0501	Belongs to the peptidase M48B family
B5J99_RS11195	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
B5J99_RS11205	COG0793	Belongs to the peptidase S41A family
B5J99_RS11215	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
B5J99_RS11220	COG0799	negative regulation of ribosome biogenesis
B5J99_RS11225	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
B5J99_RS11240	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
B5J99_RS11245	COG1196	nuclear chromosome segregation
B5J99_RS11245	COG0741	lytic transglycosylase activity
B5J99_RS11245	COG0739	heme binding
B5J99_RS11280	COG0321	lipoyl(octanoyl) transferase activity
B5J99_RS11290	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
B5J99_RS11350	COG1842	Phage shock protein A
B5J99_RS11360	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
B5J99_RS11365	COG2850	peptidyl-arginine hydroxylation
B5J99_RS11375	COG1063	alcohol dehydrogenase
B5J99_RS11400	COG0626	cystathionine gamma-synthase activity
B5J99_RS11405	COG2897	thiosulfate sulfurtransferase activity
B5J99_RS11410	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
B5J99_RS11440	COG0261	This protein binds to 23S rRNA in the presence of protein L20
B5J99_RS11445	COG0211	Belongs to the bacterial ribosomal protein bL27 family
B5J99_RS11490	COG0028	Belongs to the TPP enzyme family
B5J99_RS11500	COG1051	belongs to the nudix hydrolase family
B5J99_RS11510	COG0657	acetylesterase activity
B5J99_RS11515	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
B5J99_RS11515	COG0674	pyruvate-flavodoxin oxidoreductase activity
B5J99_RS11520	COG1013	pyruvate-flavodoxin oxidoreductase activity
B5J99_RS11550	COG2311	Membrane
B5J99_RS11575	COG1271	oxidase subunit
B5J99_RS11600	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
B5J99_RS11605	COG0588	phosphoglycerate mutase activity
B5J99_RS11620	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B5J99_RS11625	COG0564	pseudouridine synthase activity
B5J99_RS11635	COG1956	GAF domain-containing protein
B5J99_RS11685	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B5J99_RS11700	COG0037	tRNA processing
B5J99_RS11720	COG1758	RNA polymerase activity
B5J99_RS11725	COG0275	rRNA processing
B5J99_RS11730	COG2329	Antibiotic biosynthesis monooxygenase
B5J99_RS11750	COG1494	fructose-1,6-bisphosphatase
B5J99_RS11765	COG2354	Protein conserved in bacteria
B5J99_RS11780	COG0681	Belongs to the peptidase S26 family
B5J99_RS11785	COG0736	holo-[acyl-carrier-protein] synthase activity
B5J99_RS11790	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
B5J99_RS11800	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
B5J99_RS11805	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
B5J99_RS11810	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
B5J99_RS11815	COG0109	protoheme IX farnesyltransferase activity
B5J99_RS11820	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
B5J99_RS11865	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
B5J99_RS11910	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B5J99_RS11920	COG0333	Belongs to the bacterial ribosomal protein bL32 family
B5J99_RS11925	COG0416	fatty acid biosynthetic process
B5J99_RS11930	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B5J99_RS11935	COG0776	regulation of translation
B5J99_RS11955	COG1199	ATP-dependent helicase activity
B5J99_RS11960	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
B5J99_RS11970	COG0598	Magnesium transport protein CorA
B5J99_RS11975	COG0693	protein deglycase activity
B5J99_RS11990	COG3876	Protein conserved in bacteria
B5J99_RS12010	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
B5J99_RS12020	COG1610	YqeY-like protein
B5J99_RS12025	COG0505	Belongs to the CarA family
B5J99_RS12040	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B5J99_RS12070	COG0148	phosphopyruvate hydratase activity
B5J99_RS12080	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
B5J99_RS12085	COG0022	dehydrogenase e1 component
B5J99_RS12085	COG0508	dehydrogenase complex catalyzes the overall conversion of
B5J99_RS12115	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
B5J99_RS12135	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
B5J99_RS12145	COG3022	response to hydroperoxide
B5J99_RS12155	COG1522	sequence-specific DNA binding
B5J99_RS12160	COG2205	protein histidine kinase activity
B5J99_RS12195	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
B5J99_RS12200	COG0303	'Molybdopterin
B5J99_RS12205	COG0315	cyclic pyranopterin monophosphate synthase activity
B5J99_RS12210	COG0134	indole-3-glycerol-phosphate synthase activity
B5J99_RS12215	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
B5J99_RS12225	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
B5J99_RS12235	COG0149	triose-phosphate isomerase activity
B5J99_RS12240	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
B5J99_RS12245	COG0504	CTP synthase activity
B5J99_RS12255	COG0071	Belongs to the small heat shock protein (HSP20) family
B5J99_RS12265	COG1136	(ABC) transporter
B5J99_RS12270	COG0386	Belongs to the glutathione peroxidase family
B5J99_RS12285	COG0318	PFAM AMP-dependent synthetase and ligase
B5J99_RS12300	COG1040	competence protein
B5J99_RS12305	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
B5J99_RS12345	COG1529	Aldehyde oxidase and xanthine dehydrogenase
B5J99_RS12350	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
B5J99_RS12355	COG2080	2 iron, 2 sulfur cluster binding
B5J99_RS12390	COG0385	Bile acid
B5J99_RS12395	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
B5J99_RS12395	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B5J99_RS12420	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
B5J99_RS12430	COG0402	S-adenosylhomocysteine deaminase activity
B5J99_RS12435	COG1846	Transcriptional regulator
B5J99_RS12445	COG1960	acyl-CoA dehydrogenase activity
B5J99_RS12450	COG0251	oxidation-reduction process
B5J99_RS12460	COG1960	acyl-CoA dehydrogenase activity
B5J99_RS12465	COG1024	Enoyl-CoA hydratase
B5J99_RS12470	COG1846	Transcriptional regulator
B5J99_RS12475	COG1028	Short-chain dehydrogenase reductase Sdr
B5J99_RS12485	COG0436	Aminotransferase
B5J99_RS12515	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B5J99_RS12520	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B5J99_RS12525	COG0583	DNA-binding transcription factor activity
B5J99_RS12530	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B5J99_RS12545	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
B5J99_RS12550	COG0402	S-adenosylhomocysteine deaminase activity
B5J99_RS12585	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
B5J99_RS12590	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
B5J99_RS12595	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
B5J99_RS12600	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B5J99_RS12605	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
B5J99_RS12610	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
B5J99_RS12625	COG0105	UTP biosynthetic process
B5J99_RS12635	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
B5J99_RS12640	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
B5J99_RS12655	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
B5J99_RS12665	COG1045	serine acetyltransferase
B5J99_RS12680	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
B5J99_RS12685	COG0583	DNA-binding transcription factor activity
B5J99_RS12690	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
B5J99_RS12705	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
B5J99_RS12765	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B5J99_RS12780	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
B5J99_RS12785	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B5J99_RS12810	COG1960	acyl-CoA dehydrogenase activity
B5J99_RS12820	COG1960	acyl-CoA dehydrogenase activity
B5J99_RS12825	COG1960	acyl-CoA dehydrogenase activity
B5J99_RS12840	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B5J99_RS12855	COG0427	acetyl-CoA hydrolase
B5J99_RS12870	COG1028	Short-chain dehydrogenase reductase Sdr
B5J99_RS12875	COG1028	Short-chain dehydrogenase reductase Sdr
B5J99_RS12885	COG4638	Rieske (2fe-2S)
B5J99_RS12895	COG1028	Short-chain dehydrogenase reductase Sdr
B5J99_RS12915	COG1028	Short-chain dehydrogenase reductase Sdr
B5J99_RS12995	COG0028	Belongs to the TPP enzyme family
B5J99_RS13005	COG2072	flavoprotein involved in K transport
B5J99_RS13010	COG1028	Short-chain dehydrogenase reductase Sdr
B5J99_RS13020	COG1902	pentaerythritol trinitrate reductase activity
B5J99_RS13055	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B5J99_RS13085	COG1024	Enoyl-CoA hydratase
B5J99_RS13090	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B5J99_RS13105	COG0604	alcohol dehydrogenase
B5J99_RS13120	COG1028	Short-chain dehydrogenase reductase Sdr
B5J99_RS13135	COG1028	Short-chain dehydrogenase reductase Sdr
B5J99_RS13140	COG1012	belongs to the aldehyde dehydrogenase family
B5J99_RS13150	COG1024	Enoyl-CoA hydratase
B5J99_RS13155	COG1960	acyl-CoA dehydrogenase activity
B5J99_RS13195	COG1063	alcohol dehydrogenase
B5J99_RS13200	COG1028	Short-chain dehydrogenase reductase Sdr
B5J99_RS13225	COG4638	Rieske (2fe-2S)
B5J99_RS13235	COG0318	PFAM AMP-dependent synthetase and ligase
B5J99_RS13250	COG0183	Belongs to the thiolase family
B5J99_RS13260	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
B5J99_RS13270	COG2814	Major facilitator Superfamily
B5J99_RS13280	COG0511	ligase activity, forming carbon-carbon bonds
B5J99_RS13280	COG5016	pyruvate
B5J99_RS13290	COG0657	acetylesterase activity
B5J99_RS13295	COG1024	Enoyl-CoA hydratase
B5J99_RS13300	COG1053	succinate dehydrogenase
B5J99_RS13310	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
B5J99_RS13315	COG0022	dehydrogenase e1 component
B5J99_RS13330	COG1028	Short-chain dehydrogenase reductase Sdr
B5J99_RS13335	COG1063	alcohol dehydrogenase
B5J99_RS13365	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
B5J99_RS13390	COG0628	permease
B5J99_RS13430	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
B5J99_RS13435	COG0126	phosphoglycerate kinase activity
B5J99_RS13440	COG3588	fructose-bisphosphate aldolase
B5J99_RS13445	COG0352	thiamine-phosphate diphosphorylase activity
B5J99_RS13450	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
B5J99_RS13455	COG0483	inositol monophosphate 1-phosphatase activity
B5J99_RS13465	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B5J99_RS13470	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B5J99_RS13475	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B5J99_RS13480	COG0649	NAD binding
B5J99_RS13495	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
B5J99_RS13505	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
B5J99_RS13510	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B5J99_RS13520	COG0713	ATP synthesis coupled electron transport
B5J99_RS13535	COG1007	ATP synthesis coupled electron transport
B5J99_RS13545	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
B5J99_RS13560	COG1278	Cold shock
B5J99_RS13570	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
B5J99_RS13580	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
B5J99_RS13590	COG1420	regulation of RNA biosynthetic process
B5J99_RS13595	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
B5J99_RS13605	COG2847	Copper chaperone PCu(A)C
B5J99_RS13610	COG0443	Heat shock 70 kDa protein
B5J99_RS13615	COG0484	heat shock protein binding
B5J99_RS13625	COG0235	Class ii aldolase
B5J99_RS13635	COG0828	Belongs to the bacterial ribosomal protein bS21 family
B5J99_RS13640	COG0545	Peptidyl-prolyl cis-trans isomerase
B5J99_RS13650	COG4771	TonB-dependent receptor
B5J99_RS13655	COG0006	proline dipeptidase activity
B5J99_RS13705	COG0668	transmembrane transport
B5J99_RS13715	COG0183	Belongs to the thiolase family
B5J99_RS13725	COG4948	Mandelate Racemase Muconate Lactonizing
B5J99_RS13735	COG1132	(ABC) transporter
B5J99_RS13745	COG0251	oxidation-reduction process
B5J99_RS13750	COG0227	Belongs to the bacterial ribosomal protein bL28 family
B5J99_RS13755	COG0590	tRNA wobble adenosine to inosine editing
B5J99_RS13765	COG3279	Response regulator of the LytR AlgR family
B5J99_RS13770	COG2972	Histidine kinase
B5J99_RS13795	COG0501	Belongs to the peptidase M48B family
B5J99_RS13805	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
B5J99_RS13815	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
B5J99_RS13830	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
B5J99_RS13850	COG0625	glutathione transferase activity
B5J99_RS13870	COG2945	thiolester hydrolase activity
B5J99_RS13875	COG1104	cysteine desulfurase activity
B5J99_RS13900	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
B5J99_RS13905	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
B5J99_RS13915	COG0776	regulation of translation
B5J99_RS13935	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B5J99_RS13945	COG0582	viral genome integration into host DNA
B5J99_RS13950	COG4974	Belongs to the 'phage' integrase family
B5J99_RS13955	COG0517	IMP dehydrogenase activity
B5J99_RS13960	COG4974	Belongs to the 'phage' integrase family
B5J99_RS13965	COG0517	IMP dehydrogenase activity
B5J99_RS13980	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B5J99_RS13990	COG0583	DNA-binding transcription factor activity
B5J99_RS14010	COG1959	2 iron, 2 sulfur cluster binding
B5J99_RS14030	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
B5J99_RS14030	COG1017	nitric oxide dioxygenase activity
B5J99_RS14060	COG4957	zinc ion binding
B5J99_RS14080	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
B5J99_RS14110	COG3547	Transposase (IS116 IS110 IS902 family)
B5J99_RS14120	COG4651	solute:proton antiporter activity
B5J99_RS14120	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
B5J99_RS14125	COG0517	IMP dehydrogenase activity
B5J99_RS14130	COG4974	Belongs to the 'phage' integrase family
B5J99_RS14135	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B5J99_RS14140	COG0183	Belongs to the thiolase family
B5J99_RS14145	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
B5J99_RS14150	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
B5J99_RS14155	COG1252	NADH dehydrogenase
B5J99_RS14170	COG3263	regulation of cellular component size
B5J99_RS14175	COG0521	Mo-molybdopterin cofactor biosynthetic process
B5J99_RS14190	COG0644	oxidoreductase
B5J99_RS14190	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
B5J99_RS14195	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
B5J99_RS14205	COG0129	dihydroxy-acid dehydratase activity
B5J99_RS14215	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
B5J99_RS14215	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
B5J99_RS14220	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B5J99_RS14245	COG1748	Saccharopine dehydrogenase
B5J99_RS14255	COG1595	DNA-templated transcription, initiation
B5J99_RS14265	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
B5J99_RS14275	COG4106	trans-aconitate 2-methyltransferase activity
B5J99_RS14280	COG1793	dna ligase
B5J99_RS14290	COG3038	cytochrome b561
B5J99_RS14295	COG0156	8-amino-7-oxononanoate synthase activity
B5J99_RS14300	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
B5J99_RS14305	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
B5J99_RS14310	COG0758	DNA mediated transformation
B5J99_RS14325	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
B5J99_RS14330	COG0571	ribonuclease III activity
B5J99_RS14335	COG0681	Belongs to the peptidase S26 family
B5J99_RS14340	COG0166	Belongs to the GPI family
B5J99_RS14350	COG1396	sequence-specific DNA binding
B5J99_RS14350	COG3800	Transcriptional regulator
B5J99_RS14355	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B5J99_RS14360	COG0346	lactoylglutathione lyase activity
B5J99_RS14365	COG1024	Enoyl-CoA hydratase
B5J99_RS14370	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B5J99_RS14370	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B5J99_RS14375	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
B5J99_RS14385	COG4770	biotin carboxylase activity
B5J99_RS14395	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
B5J99_RS14405	COG0596	Alpha beta hydrolase
B5J99_RS14410	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
B5J99_RS14415	COG0442	prolyl-tRNA aminoacylation
B5J99_RS14420	COG0557	exoribonuclease II activity
B5J99_RS14430	COG0508	dehydrogenase complex catalyzes the overall conversion of
B5J99_RS14435	COG2852	Protein conserved in bacteria
B5J99_RS14445	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B5J99_RS14460	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
B5J99_RS14490	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B5J99_RS14500	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
B5J99_RS14505	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
B5J99_RS14520	COG4974	Belongs to the 'phage' integrase family
B5J99_RS14525	COG0825	malonyl-CoA metabolic process
B5J99_RS14530	COG0501	Belongs to the peptidase M48B family
B5J99_RS14580	COG0596	Alpha beta hydrolase
B5J99_RS14620	COG1462	curli production assembly transport component CsgG
B5J99_RS14635	COG2951	lytic endotransglycosylase activity
B5J99_RS14645	COG1686	Belongs to the peptidase S11 family
B5J99_RS14650	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
B5J99_RS14665	COG0084	hydrolase, TatD family'
B5J99_RS14670	COG0321	lipoyl(octanoyl) transferase activity
B5J99_RS14670	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
B5J99_RS14680	COG3956	TIGRFAM MazG family protein
B5J99_RS14685	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
B5J99_RS14690	COG1923	regulation of RNA biosynthetic process
B5J99_RS14695	COG2204	response regulator
B5J99_RS14700	COG5000	phosphorelay sensor kinase activity
B5J99_RS14705	COG2204	response regulator
B5J99_RS14720	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
B5J99_RS14720	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
B5J99_RS14730	COG1058	Belongs to the CinA family
B5J99_RS14730	COG1546	Belongs to the CinA family
B5J99_RS14740	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
B5J99_RS14745	COG0259	pyridoxamine-phosphate oxidase activity
B5J99_RS14765	COG0583	DNA-binding transcription factor activity
B5J99_RS14770	COG0518	GMP synthase (glutamine-hydrolyzing) activity
B5J99_RS14770	COG0519	Catalyzes the synthesis of GMP from XMP
B5J99_RS14775	COG0318	PFAM AMP-dependent synthetase and ligase
B5J99_RS14800	COG2814	Major facilitator Superfamily
B5J99_RS14805	COG0531	amino acid
B5J99_RS14820	COG0140	phosphoribosyl-ATP diphosphatase activity
B5J99_RS14830	COG0107	imidazoleglycerol-phosphate synthase activity
B5J99_RS14835	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
B5J99_RS14840	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
B5J99_RS14845	COG0131	Imidazoleglycerol-phosphate dehydratase
B5J99_RS14855	COG0114	fumarate hydratase activity
B5J99_RS14865	COG0194	GDP metabolic process
B5J99_RS14880	COG1960	acyl-CoA dehydrogenase activity
B5J99_RS14885	COG1960	acyl-CoA dehydrogenase activity
B5J99_RS14890	COG1960	acyl-CoA dehydrogenase activity
B5J99_RS14895	COG2211	Major facilitator Superfamily
B5J99_RS14900	COG1960	acyl-CoA dehydrogenase activity
B5J99_RS14930	COG1024	Enoyl-CoA hydratase
B5J99_RS14930	COG1250	3-hydroxyacyl-CoA dehydrogenase
B5J99_RS14950	COG0546	phosphoglycolate phosphatase activity
B5J99_RS14960	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
B5J99_RS14970	COG0616	signal peptide processing
B5J99_RS14995	COG3220	belongs to the UPF0276 family
B5J99_RS15005	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
B5J99_RS15010	COG0459	protein refolding
B5J99_RS15030	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B5J99_RS15030	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B5J99_RS15040	COG0077	Prephenate dehydratase
B5J99_RS15045	COG3474	cytochrome
B5J99_RS15075	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
B5J99_RS15075	COG1648	precorrin-2 dehydrogenase activity
B5J99_RS15080	COG0019	diaminopimelate decarboxylase activity
B5J99_RS15090	COG0165	Argininosuccinate lyase
B5J99_RS15095	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B5J99_RS15110	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
B5J99_RS15115	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
B5J99_RS15120	COG0635	Involved in the biosynthesis of porphyrin-containing compound
B5J99_RS15125	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
B5J99_RS15130	COG0586	Pfam SNARE associated Golgi protein
B5J99_RS15135	COG0189	ligase activity
B5J99_RS15140	COG0792	nuclease activity
B5J99_RS15145	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
B5J99_RS15155	COG1024	Enoyl-CoA hydratase
B5J99_RS15180	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
B5J99_RS15225	COG1393	Belongs to the ArsC family
B5J99_RS15245	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
B5J99_RS15250	COG0183	Belongs to the thiolase family
B5J99_RS15255	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
B5J99_RS15265	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B5J99_RS15270	COG4771	TonB-dependent receptor
B5J99_RS15285	COG0277	FAD linked oxidase domain protein
B5J99_RS15295	COG0318	PFAM AMP-dependent synthetase and ligase
B5J99_RS15310	COG0784	Response regulator, receiver
B5J99_RS15345	COG1230	cation diffusion facilitator family transporter
B5J99_RS15350	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
B5J99_RS15360	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
B5J99_RS15370	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
B5J99_RS15380	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
B5J99_RS15390	COG0653	protein targeting
B5J99_RS15420	COG1752	Esterase of the alpha-beta hydrolase superfamily
B5J99_RS15420	COG1752	Esterase of the alpha-beta hydrolase superfamily
B5J99_RS15430	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
B5J99_RS15435	COG0193	aminoacyl-tRNA hydrolase activity
B5J99_RS15460	COG0012	GTP binding
B5J99_RS15465	COG3540	Alkaline phosphatase
B5J99_RS15475	COG2030	dehydratase
B5J99_RS15475	COG1012	belongs to the aldehyde dehydrogenase family
B5J99_RS15485	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
B5J99_RS15505	COG0768	penicillin binding
B5J99_RS15510	COG0772	Belongs to the SEDS family
B5J99_RS15525	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
B5J99_RS15540	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
B5J99_RS15545	COG1845	cytochrome c oxidase, subunit III
B5J99_RS15550	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
B5J99_RS15555	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
B5J99_RS15560	COG0477	Major facilitator Superfamily
B5J99_RS15600	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B5J99_RS15605	COG0004	ammonium transporteR
B5J99_RS15610	COG0481	GTPase activity
B5J99_RS15615	COG0517	IMP dehydrogenase activity
B5J99_RS15620	COG4974	Belongs to the 'phage' integrase family
B5J99_RS15625	COG4206	TonB-dependent receptor
B5J99_RS15645	COG0314	molybdopterin synthase activity
B5J99_RS15655	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
B5J99_RS15670	COG0415	Belongs to the DNA photolyase family
B5J99_RS15700	COG0540	Belongs to the ATCase OTCase family
B5J99_RS15705	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B5J99_RS15725	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
B5J99_RS15725	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
B5J99_RS15750	COG1295	ribonuclease BN
B5J99_RS15750	COG1959	2 iron, 2 sulfur cluster binding
B5J99_RS15770	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
B5J99_RS15775	COG2133	pyrroloquinoline quinone binding
B5J99_RS15780	COG1012	belongs to the aldehyde dehydrogenase family
B5J99_RS15790	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
B5J99_RS15795	COG0625	glutathione transferase activity
B5J99_RS15810	COG1074	ATP-dependent DNA helicase activity
B5J99_RS15815	COG2887	Belongs to the helicase family. UvrD subfamily
B5J99_RS15820	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
B5J99_RS15830	COG0802	atpase or kinase
B5J99_RS15835	COG2205	protein histidine kinase activity
B5J99_RS15840	COG0793	Belongs to the peptidase S41A family
B5J99_RS15840	COG4946	Tricorn protease homolog
B5J99_RS15845	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
B5J99_RS15850	COG0678	peroxiredoxin activity
B5J99_RS15850	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
B5J99_RS15855	COG0302	gtp cyclohydrolase
B5J99_RS15860	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B5J99_RS15895	COG2205	protein histidine kinase activity
B5J99_RS15905	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
B5J99_RS15925	COG0583	DNA-binding transcription factor activity
B5J99_RS15965	COG1136	(ABC) transporter
B5J99_RS15965	COG0577	efflux transmembrane transporter activity
B5J99_RS15970	COG1136	(ABC) transporter
B5J99_RS15975	COG1566	PFAM secretion protein HlyD family protein
B5J99_RS16010	COG0175	sulfate reduction
B5J99_RS16045	COG5001	Diguanylate cyclase
B5J99_RS16050	COG3507	Belongs to the glycosyl hydrolase 43 family
B5J99_RS16070	COG0477	Major facilitator Superfamily
B5J99_RS16080	COG3661	Belongs to the glycosyl hydrolase 67 family
B5J99_RS16085	COG1472	Belongs to the glycosyl hydrolase 3 family
B5J99_RS16090	COG4948	Mandelate Racemase Muconate Lactonizing
B5J99_RS16095	COG2271	Major facilitator Superfamily
B5J99_RS16110	COG4771	TonB-dependent receptor
B5J99_RS16120	COG2186	Transcriptional regulator
B5J99_RS16135	COG3258	Cytochrome c
B5J99_RS16170	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
B5J99_RS16180	COG3383	formate dehydrogenase (NAD+) activity
B5J99_RS16210	COG0612	Peptidase, M16
B5J99_RS16220	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
B5J99_RS16225	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B5J99_RS16250	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
B5J99_RS16255	COG0714	Associated with various cellular activities
B5J99_RS16275	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
B5J99_RS16285	COG3447	MASE1 domain protein
B5J99_RS16285	COG5002	protein histidine kinase activity
B5J99_RS16285	COG5001	Diguanylate cyclase
B5J99_RS16295	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
B5J99_RS16310	COG0196	riboflavin kinase activity
B5J99_RS16315	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
B5J99_RS16320	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
B5J99_RS16330	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
B5J99_RS16340	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B5J99_RS16360	COG1760	l-serine dehydratase
B5J99_RS16365	COG2333	competence protein COMEC
B5J99_RS16365	COG0658	competence protein
B5J99_RS16370	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B5J99_RS16375	COG0372	Belongs to the citrate synthase family
B5J99_RS16385	COG0406	alpha-ribazole phosphatase activity
B5J99_RS16400	COG0820	rRNA (adenine-C2-)-methyltransferase activity
B5J99_RS16410	COG3153	acetyltransferase
B5J99_RS16410	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B5J99_RS16415	COG0538	isocitrate dehydrogenase activity
B5J99_RS16420	COG0688	phosphatidylethanolamine metabolic process
B5J99_RS16435	COG0052	Belongs to the universal ribosomal protein uS2 family
B5J99_RS16440	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
B5J99_RS16445	COG0528	UMP kinase activity
B5J99_RS16450	COG0233	cytoplasmic translational termination
B5J99_RS16455	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
B5J99_RS16465	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
B5J99_RS16470	COG0750	zinc metalloprotease
B5J99_RS16475	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B5J99_RS16485	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
B5J99_RS16490	COG0254	rRNA binding
B5J99_RS16495	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
B5J99_RS16500	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
B5J99_RS16525	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B5J99_RS16530	COG0741	lytic transglycosylase activity
B5J99_RS16545	COG1012	belongs to the aldehyde dehydrogenase family
B5J99_RS16570	COG0215	cysteine-tRNA ligase activity
B5J99_RS16595	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B5J99_RS16605	COG0484	heat shock protein binding
B5J99_RS16625	COG0596	Alpha beta hydrolase
B5J99_RS16630	COG0517	IMP dehydrogenase activity
B5J99_RS16635	COG4974	Belongs to the 'phage' integrase family
B5J99_RS16645	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
B5J99_RS16650	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
B5J99_RS16655	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B5J99_RS16660	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
B5J99_RS16665	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
B5J99_RS16680	COG0688	phosphatidylethanolamine metabolic process
B5J99_RS16690	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
B5J99_RS16725	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B5J99_RS16750	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
B5J99_RS16770	COG1024	Enoyl-CoA hydratase
B5J99_RS16785	COG0318	PFAM AMP-dependent synthetase and ligase
B5J99_RS16805	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B5J99_RS16810	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B5J99_RS16815	COG0509	glycine decarboxylation via glycine cleavage system
B5J99_RS16820	COG0404	The glycine cleavage system catalyzes the degradation of glycine
B5J99_RS16825	COG0232	Belongs to the dGTPase family. Type 2 subfamily
B5J99_RS16860	COG0514	ATP-dependent DNA helicase (RecQ)
B5J99_RS16875	COG1262	PFAM Formylglycine-generating sulfatase enzyme
B5J99_RS16885	COG3119	arylsulfatase activity
B5J99_RS16900	COG3300	MHYT domain
B5J99_RS16900	COG5001	Diguanylate cyclase
B5J99_RS16910	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
B5J99_RS16950	COG0183	Belongs to the thiolase family
B5J99_RS16965	COG0318	PFAM AMP-dependent synthetase and ligase
B5J99_RS16970	COG0739	heme binding
B5J99_RS16975	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
B5J99_RS16980	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
B5J99_RS16995	COG2957	Belongs to the agmatine deiminase family
B5J99_RS17010	COG1573	uracil-dna glycosylase
B5J99_RS17015	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
B5J99_RS17040	COG1216	Glycosyl transferase, family 2
B5J99_RS17055	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
B5J99_RS17070	COG2169	Transcriptional regulator
B5J99_RS17070	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
B5J99_RS17080	COG0840	transmembrane signaling receptor activity
B5J99_RS17085	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B5J99_RS17090	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
B5J99_RS17095	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
B5J99_RS17100	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
B5J99_RS17105	COG0355	proton-transporting ATP synthase activity, rotational mechanism
B5J99_RS17135	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
B5J99_RS17145	COG1058	Belongs to the CinA family
B5J99_RS17145	COG1546	Belongs to the CinA family
B5J99_RS17160	COG0024	Methionine aminopeptidase
B5J99_RS17165	COG0347	Belongs to the P(II) protein family
B5J99_RS17170	COG0174	glutamine synthetase
B5J99_RS17185	COG4166	transmembrane transport
B5J99_RS17195	COG0583	DNA-binding transcription factor activity
B5J99_RS17205	COG2239	Acts as a magnesium transporter
B5J99_RS17215	COG2827	Endonuclease containing a URI domain
B5J99_RS17225	COG1250	3-hydroxyacyl-CoA dehydrogenase
B5J99_RS17235	COG0454	-acetyltransferase
B5J99_RS17250	COG2030	dehydratase
B5J99_RS17255	COG4770	biotin carboxylase activity
B5J99_RS17265	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B5J99_RS17270	COG1960	acyl-CoA dehydrogenase activity
B5J99_RS17275	COG0583	DNA-binding transcription factor activity
B5J99_RS17285	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B5J99_RS17285	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
B5J99_RS17305	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B5J99_RS17320	COG1660	Displays ATPase and GTPase activities
B5J99_RS17325	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
B5J99_RS17330	COG2205	protein histidine kinase activity
B5J99_RS17335	COG0745	RESPONSE REGULATOR receiver
B5J99_RS17340	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
B5J99_RS17360	COG1322	Protein conserved in bacteria
B5J99_RS17365	COG0242	peptide deformylase activity
B5J99_RS17375	COG1160	GTP binding
B5J99_RS17395	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
B5J99_RS17400	COG0424	maF-like protein
B5J99_RS17410	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
B5J99_RS17450	COG1573	uracil-dna glycosylase
B5J99_RS17465	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
B5J99_RS17480	COG0039	L-malate dehydrogenase activity
B5J99_RS17490	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
B5J99_RS17505	COG0508	dehydrogenase complex catalyzes the overall conversion of
B5J99_RS17510	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B5J99_RS17535	COG1201	RNA secondary structure unwinding
B5J99_RS17570	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
B5J99_RS17575	COG0113	porphobilinogen synthase activity
B5J99_RS17580	COG2205	protein histidine kinase activity
B5J99_RS17595	COG0488	(ABC) transporter
B5J99_RS17600	COG0183	Belongs to the thiolase family
B5J99_RS17635	COG4946	Tricorn protease homolog
B5J99_RS17635	COG1506	peptidase
B5J99_RS17635	COG0823	Involved in the tonB-independent uptake of proteins
B5J99_RS17645	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
B5J99_RS17650	COG1192	Involved in chromosome partitioning
B5J99_RS17675	COG2321	neutral zinc metallopeptidase
B5J99_RS17685	COG1304	FMN binding
B5J99_RS17700	COG1459	type II secretion system
B5J99_RS17705	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
B5J99_RS17740	COG3590	peptidase
B5J99_RS17760	COG3268	Saccharopine dehydrogenase
B5J99_RS17770	COG1028	Short-chain dehydrogenase reductase Sdr
B5J99_RS17780	COG0145	ligase activity
B5J99_RS17785	COG3246	L-lysine catabolic process to acetate
B5J99_RS17790	COG2814	Major facilitator Superfamily
B5J99_RS17805	COG4771	TonB-dependent receptor
B5J99_RS17815	COG0318	PFAM AMP-dependent synthetase and ligase
B5J99_RS17830	COG1376	ErfK ybiS ycfS ynhG family protein
B5J99_RS17840	COG0583	DNA-binding transcription factor activity
B5J99_RS17845	COG4221	oxidoreductase activity
B5J99_RS17865	COG0129	dihydroxy-acid dehydratase activity
B5J99_RS17895	COG1028	Short-chain dehydrogenase reductase Sdr
B5J99_RS17900	COG1414	Transcriptional regulator
B5J99_RS17905	COG4948	Mandelate Racemase Muconate Lactonizing
B5J99_RS17915	COG1028	Short-chain dehydrogenase reductase Sdr
B5J99_RS17935	COG3693	PFAM glycoside hydrolase, family 10
B5J99_RS17980	COG0438	transferase activity, transferring glycosyl groups
B5J99_RS18010	COG1216	Glycosyl transferase, family 2
B5J99_RS18030	COG0428	transporter
B5J99_RS18045	COG4974	Belongs to the 'phage' integrase family
B5J99_RS18050	COG0517	IMP dehydrogenase activity
B5J99_RS18065	COG2271	Major facilitator Superfamily
B5J99_RS18075	COG3246	L-lysine catabolic process to acetate
B5J99_RS18080	COG2175	clavaminate synthase activity
B5J99_RS18095	COG0517	IMP dehydrogenase activity
B5J99_RS18100	COG4974	Belongs to the 'phage' integrase family
B5J99_RS18145	COG0517	IMP dehydrogenase activity
B5J99_RS18150	COG0517	IMP dehydrogenase activity
B5J99_RS18155	COG4974	Belongs to the 'phage' integrase family
B5J99_RS18170	COG0582	viral genome integration into host DNA
B5J99_RS18180	COG4974	Belongs to the 'phage' integrase family
B5J99_RS18185	COG0517	IMP dehydrogenase activity
B5J99_RS18220	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
B5J99_RS18245	COG4957	zinc ion binding
B5J99_RS18255	COG3547	Transposase (IS116 IS110 IS902 family)
B5J99_RS18280	COG3547	Transposase (IS116 IS110 IS902 family)
B5J99_RS18285	COG0517	IMP dehydrogenase activity
B5J99_RS18290	COG4974	Belongs to the 'phage' integrase family
B5J99_RS18305	COG0443	Heat shock 70 kDa protein
B5J99_RS18310	COG0582	viral genome integration into host DNA
B5J99_RS18325	COG2902	Dehydrogenase
B5J99_RS18340	COG3655	Transcriptional regulator
B5J99_RS18345	COG0517	IMP dehydrogenase activity
B5J99_RS18350	COG4974	Belongs to the 'phage' integrase family
B5J99_RS18365	COG1024	Enoyl-CoA hydratase
B5J99_RS18370	COG1960	acyl-CoA dehydrogenase activity
B5J99_RS18375	COG1960	acyl-CoA dehydrogenase activity
B5J99_RS18390	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B5J99_RS18390	COG0574	Belongs to the PEP-utilizing enzyme family
B5J99_RS18395	COG0751	glycine-tRNA ligase activity
B5J99_RS18400	COG0752	glycyl-tRNA synthetase alpha subunit
B5J99_RS18405	COG0243	molybdopterin cofactor binding
B5J99_RS18430	COG0596	Alpha beta hydrolase
B5J99_RS18435	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
B5J99_RS18440	COG3186	Phenylalanine-4-hydroxylase
B5J99_RS18450	COG2860	membrane
B5J99_RS18465	COG1505	serine-type exopeptidase activity
B5J99_RS18470	COG0203	ribosomal protein L17
B5J99_RS18475	COG0202	RNA polymerase activity
B5J99_RS18480	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
B5J99_RS18485	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
B5J99_RS18505	COG0438	transferase activity, transferring glycosyl groups
B5J99_RS18515	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
B5J99_RS18520	COG2733	membrane
B5J99_RS18550	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
B5J99_RS18565	COG2208	phosphoserine phosphatase activity
B5J99_RS18570	COG2301	Belongs to the HpcH HpaI aldolase family
B5J99_RS18580	COG0154	amidase activity
B5J99_RS18595	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
B5J99_RS18600	COG2721	sulfolactate sulfo-lyase activity
B5J99_RS18605	COG0129	dihydroxy-acid dehydratase activity
B5J99_RS18640	COG2205	protein histidine kinase activity
B5J99_RS18640	COG0784	Response regulator, receiver
B5J99_RS18820	COG1475	DNA binding
B5J99_RS18825	COG3547	Transposase (IS116 IS110 IS902 family)
B5J99_RS18830	COG4974	Belongs to the 'phage' integrase family
B5J99_RS18835	COG0517	IMP dehydrogenase activity
B5J99_RS18845	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B5J99_RS18885	COG1192	Involved in chromosome partitioning
B5J99_RS18980	COG0739	heme binding
B5J99_RS18980	COG0741	lytic transglycosylase activity
B5J99_RS18980	COG1196	nuclear chromosome segregation
B5J99_RS19185	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
B5J99_RS19195	COG2189	Belongs to the N(4) N(6)-methyltransferase family
B5J99_RS19215	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
B5J99_RS19225	COG3742	Toxic component of a toxin-antitoxin (TA) module. An RNase
B5J99_RS19230	COG1476	TRANSCRIPTIONal
B5J99_RS19260	COG1999	signal sequence binding
B5J99_RS19275	COG0640	Transcriptional regulator
B5J99_RS19280	COG0450	alkyl hydroperoxide reductase
B5J99_RS19315	COG0450	alkyl hydroperoxide reductase
B5J99_RS19330	COG3258	Cytochrome c
B5J99_RS19350	COG1294	oxidase, subunit
B5J99_RS19365	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
B5J99_RS19370	COG0783	Belongs to the Dps family
B5J99_RS19385	COG1061	Type III restriction enzyme res subunit