locus-tag	class	description
H0H58_RS00005	COG0195	Participates in both transcription termination and antitermination
H0H58_RS00010	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
H0H58_RS00015	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H0H58_RS00020	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H0H58_RS00025	COG0508	dehydrogenase complex catalyzes the overall conversion of
H0H58_RS00030	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H0H58_RS00035	COG0815	Transfers the fatty acyl group on membrane lipoproteins
H0H58_RS00045	COG0772	Belongs to the SEDS family
H0H58_RS00050	COG0768	penicillin binding
H0H58_RS00065	COG1077	Cell shape determining protein MreB Mrl
H0H58_RS00070	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H0H58_RS00075	COG0251	oxidation-reduction process
H0H58_RS00080	COG0101	tRNA pseudouridine synthase activity
H0H58_RS00085	COG1132	(ABC) transporter
H0H58_RS00095	COG0039	L-malate dehydrogenase activity
H0H58_RS00100	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H0H58_RS00100	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H0H58_RS00105	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H0H58_RS00110	COG1480	7TM receptor with intracellular HD hydrolase
H0H58_RS00130	COG0740	serine-type endopeptidase activity
H0H58_RS00150	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H0H58_RS00155	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H0H58_RS00160	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
H0H58_RS00160	COG0321	lipoyl(octanoyl) transferase activity
H0H58_RS00165	COG1333	cytochrome c biogenesis protein
H0H58_RS00165	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H0H58_RS00170	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H0H58_RS00175	COG0567	Dehydrogenase, E1 component
H0H58_RS00180	COG0508	dehydrogenase complex catalyzes the overall conversion of
H0H58_RS00195	COG0045	succinate-CoA ligase (ADP-forming) activity
H0H58_RS00205	COG0542	response to heat
H0H58_RS00210	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H0H58_RS00225	COG2151	metal-sulfur cluster biosynthetic enzyme
H0H58_RS00235	COG0612	Peptidase, M16
H0H58_RS00245	COG0437	4 iron, 4 sulfur cluster binding
H0H58_RS00270	COG0569	domain protein
H0H58_RS00275	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H0H58_RS00280	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H0H58_RS00285	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H0H58_RS00290	COG0302	gtp cyclohydrolase
H0H58_RS00295	COG0215	cysteine-tRNA ligase activity
H0H58_RS00300	COG0626	cystathionine gamma-synthase activity
H0H58_RS00305	COG0356	it plays a direct role in the translocation of protons across the membrane
H0H58_RS00310	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H0H58_RS00315	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H0H58_RS00330	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
H0H58_RS00335	COG0180	Tryptophanyl-tRNA synthetase
H0H58_RS00340	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H0H58_RS00345	COG0484	heat shock protein binding
H0H58_RS00355	COG0129	dihydroxy-acid dehydratase activity
H0H58_RS00360	COG0028	Belongs to the TPP enzyme family
H0H58_RS00370	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
H0H58_RS00375	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H0H58_RS00385	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
H0H58_RS00400	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H0H58_RS00405	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
H0H58_RS00425	COG0776	regulation of translation
H0H58_RS00430	COG1530	ribonuclease E activity
H0H58_RS00450	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H0H58_RS00455	COG0084	hydrolase, TatD family'
H0H58_RS00460	COG0114	fumarate hydratase activity
H0H58_RS00500	COG0552	protein localization to endoplasmic reticulum
H0H58_RS00510	COG0267	Belongs to the bacterial ribosomal protein bL33 family
H0H58_RS00515	COG0227	Belongs to the bacterial ribosomal protein bL28 family
H0H58_RS00520	COG0217	transcriptional regulatory protein
H0H58_RS00555	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H0H58_RS00560	COG0439	Biotin carboxylase
H0H58_RS00565	COG0511	ligase activity, forming carbon-carbon bonds
H0H58_RS00570	COG0333	Belongs to the bacterial ribosomal protein bL32 family
H0H58_RS00575	COG0442	prolyl-tRNA aminoacylation
H0H58_RS00580	COG0167	dihydroorotate dehydrogenase activity
H0H58_RS00585	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H0H58_RS00590	COG2095	MarC family integral membrane protein
H0H58_RS00605	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
H0H58_RS00630	COG0804	urea catabolic process
H0H58_RS00635	COG0832	Belongs to the urease beta subunit family
H0H58_RS00635	COG0831	urea catabolic process
H0H58_RS00640	COG0460	homoserine dehydrogenase
H0H58_RS00640	COG0527	aspartate kinase activity
H0H58_RS00645	COG0083	homoserine kinase activity
H0H58_RS00650	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H0H58_RS00660	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H0H58_RS00665	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
H0H58_RS00680	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
H0H58_RS00690	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
H0H58_RS00695	COG2255	four-way junction helicase activity
H0H58_RS00700	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H0H58_RS00710	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H0H58_RS00715	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
H0H58_RS00720	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H0H58_RS00725	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
H0H58_RS00730	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H0H58_RS00740	COG0138	bifunctional purine biosynthesis protein purh
H0H58_RS00745	COG0151	Belongs to the GarS family
H0H58_RS00750	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H0H58_RS00750	COG0519	Catalyzes the synthesis of GMP from XMP
H0H58_RS00755	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H0H58_RS00760	COG0191	fructose-bisphosphate aldolase activity
H0H58_RS00765	COG1074	ATP-dependent DNA helicase activity
H0H58_RS00770	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H0H58_RS00775	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
H0H58_RS00795	COG0517	IMP dehydrogenase activity
H0H58_RS00795	COG0617	tRNA 3'-terminal CCA addition
H0H58_RS00795	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
H0H58_RS00800	COG0009	L-threonylcarbamoyladenylate synthase
H0H58_RS00805	COG2171	N-acyltransferase activity
H0H58_RS00810	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H0H58_RS00815	COG0242	peptide deformylase activity
H0H58_RS00820	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
H0H58_RS00830	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
H0H58_RS00835	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H0H58_RS00840	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H0H58_RS00850	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
H0H58_RS00855	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H0H58_RS00860	COG0018	arginyl-trna synthetase
H0H58_RS00865	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H0H58_RS00870	COG0022	dehydrogenase e1 component
H0H58_RS00875	COG0105	UTP biosynthetic process
H0H58_RS00880	COG1704	LemA family
H0H58_RS00890	COG0525	valine-tRNA ligase activity
H0H58_RS00895	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
H0H58_RS00900	COG0508	dehydrogenase complex catalyzes the overall conversion of
H0H58_RS00900	COG0022	dehydrogenase e1 component
H0H58_RS00905	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
H0H58_RS00910	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H0H58_RS00915	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H0H58_RS00920	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H0H58_RS00925	COG0140	phosphoribosyl-ATP diphosphatase activity
H0H58_RS00925	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H0H58_RS00930	COG0107	imidazoleglycerol-phosphate synthase activity
H0H58_RS00935	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
H0H58_RS00940	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H0H58_RS00945	COG0131	Imidazoleglycerol-phosphate dehydratase
H0H58_RS00950	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H0H58_RS00955	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H0H58_RS00960	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H0H58_RS00965	COG0708	Exodeoxyribonuclease III
H0H58_RS00980	COG0037	tRNA processing
H0H58_RS00985	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
H0H58_RS00995	COG0133	tryptophan synthase activity
H0H58_RS01000	COG0135	phosphoribosylanthranilate isomerase activity
H0H58_RS01005	COG0134	indole-3-glycerol-phosphate synthase activity
H0H58_RS01010	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H0H58_RS01015	COG0512	Glutamine amidotransferase of anthranilate synthase
H0H58_RS01015	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H0H58_RS01020	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H0H58_RS01025	COG0509	glycine decarboxylation via glycine cleavage system
H0H58_RS01030	COG2217	Heavy metal translocating P-type atpase
H0H58_RS01055	COG0280	phosphate acetyltransferase
H0H58_RS01055	COG0281	malic enzyme
H0H58_RS01060	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H0H58_RS01065	COG0268	Binds directly to 16S ribosomal RNA
H0H58_RS01085	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H0H58_RS01095	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
H0H58_RS01100	COG0805	protein transport
H0H58_RS01105	COG0012	GTP binding
H0H58_RS01110	COG1363	Peptidase, m42
H0H58_RS01115	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
H0H58_RS01120	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H0H58_RS01135	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H0H58_RS01140	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H0H58_RS01145	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H0H58_RS01150	COG0772	Belongs to the SEDS family
H0H58_RS01155	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H0H58_RS01160	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H0H58_RS01175	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H0H58_RS01180	COG0124	histidyl-tRNA synthetase
H0H58_RS01190	COG0489	protein tyrosine kinase activity
H0H58_RS01195	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H0H58_RS01210	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H0H58_RS01215	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H0H58_RS01230	COG0632	four-way junction helicase activity
H0H58_RS01240	COG0336	Belongs to the RNA methyltransferase TrmD family
H0H58_RS01245	COG0187	DNA topoisomerase II activity
H0H58_RS01250	COG1968	undecaprenyl-diphosphatase activity
H0H58_RS01260	COG0228	four-way junction DNA binding
H0H58_RS01270	COG1301	dicarboxylic acid transport
H0H58_RS01285	COG0436	Aminotransferase
H0H58_RS01290	COG0357	Ribosomal RNA small subunit methyltransferase G
H0H58_RS01295	COG0402	S-adenosylhomocysteine deaminase activity
H0H58_RS01300	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
H0H58_RS01305	COG0321	lipoyl(octanoyl) transferase activity
H0H58_RS01310	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H0H58_RS01315	COG0450	alkyl hydroperoxide reductase
H0H58_RS01320	COG0358	DNA primase activity
H0H58_RS01325	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H0H58_RS01330	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H0H58_RS01335	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H0H58_RS01345	COG0287	Prephenate dehydrogenase
H0H58_RS01350	COG0436	Aminotransferase
H0H58_RS01365	COG0359	binds to the 23S rRNA
H0H58_RS01375	COG0360	Binds together with S18 to 16S ribosomal RNA
H0H58_RS01380	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H0H58_RS01385	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
H0H58_RS01395	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H0H58_RS01405	COG0019	diaminopimelate decarboxylase activity
H0H58_RS01415	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H0H58_RS01415	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H0H58_RS01425	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
H0H58_RS01430	COG1674	ftsk spoiiie
H0H58_RS01435	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H0H58_RS01435	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H0H58_RS01445	COG3118	belongs to the thioredoxin family
H0H58_RS01450	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H0H58_RS01455	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H0H58_RS01465	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H0H58_RS01470	COG0505	Belongs to the CarA family
H0H58_RS01475	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H0H58_RS01485	COG0137	argininosuccinate synthase activity
H0H58_RS01495	COG0539	negative regulation of cytoplasmic translation
H0H58_RS01495	COG2183	response to ionizing radiation
H0H58_RS01500	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H0H58_RS01530	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H0H58_RS01535	COG0142	geranyltranstransferase activity
H0H58_RS01550	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
H0H58_RS01555	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H0H58_RS01560	COG0194	GDP metabolic process
H0H58_RS01570	COG0698	ribose 5-phosphate isomerase
H0H58_RS01575	COG0126	phosphoglycerate kinase activity
H0H58_RS01580	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H0H58_RS01600	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H0H58_RS01605	COG0297	glycogen (starch) synthase activity
H0H58_RS01610	COG0557	exoribonuclease II activity
H0H58_RS01615	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H0H58_RS01625	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H0H58_RS01635	COG1045	serine acetyltransferase
H0H58_RS01640	COG0538	isocitrate dehydrogenase activity
H0H58_RS01655	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
H0H58_RS01660	COG1575	Belongs to the MenA family. Type 1 subfamily
H0H58_RS01665	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
H0H58_RS01675	COG0148	phosphopyruvate hydratase activity
H0H58_RS01680	COG0203	ribosomal protein L17
H0H58_RS01685	COG0202	RNA polymerase activity
H0H58_RS01690	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
H0H58_RS01700	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
H0H58_RS01710	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
H0H58_RS01715	COG0201	protein transport
H0H58_RS01720	COG0200	Binds to the 23S rRNA
H0H58_RS01735	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
H0H58_RS01740	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H0H58_RS01745	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
H0H58_RS01755	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
H0H58_RS01760	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
H0H58_RS01775	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
H0H58_RS01785	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
H0H58_RS01790	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H0H58_RS01795	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H0H58_RS01800	COG0089	rRNA binding
H0H58_RS01805	COG0088	Forms part of the polypeptide exit tunnel
H0H58_RS01815	COG0051	transcription antitermination factor activity, RNA binding
H0H58_RS01830	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H0H58_RS01840	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
H0H58_RS01845	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H0H58_RS01855	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H0H58_RS01860	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H0H58_RS01870	COG0688	phosphatidylethanolamine metabolic process
H0H58_RS01875	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H0H58_RS01880	COG0799	negative regulation of ribosome biogenesis
H0H58_RS01885	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
H0H58_RS01885	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
H0H58_RS01890	COG0706	membrane insertase activity
H0H58_RS01895	COG0504	CTP synthase activity
H0H58_RS01900	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
H0H58_RS01910	COG0563	adenylate kinase activity
H0H58_RS01915	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H0H58_RS01920	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H0H58_RS01935	COG1528	Iron-storage protein
H0H58_RS01945	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
H0H58_RS01965	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
H0H58_RS01985	COG1132	(ABC) transporter
H0H58_RS01990	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H0H58_RS02000	COG0237	dephospho-CoA kinase activity
H0H58_RS02015	COG1252	NADH dehydrogenase
H0H58_RS02025	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
H0H58_RS02035	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H0H58_RS02040	COG0534	Mate efflux family protein
H0H58_RS02045	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
H0H58_RS02060	COG0285	dihydrofolate synthase activity
H0H58_RS02070	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H0H58_RS02075	COG0085	RNA polymerase activity
H0H58_RS02080	COG0222	ribosome binding
H0H58_RS02085	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H0H58_RS02090	COG0081	regulation of translation
H0H58_RS02140	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
H0H58_RS02145	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H0H58_RS02150	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
H0H58_RS02165	COG0517	IMP dehydrogenase activity
H0H58_RS02165	COG0516	GMP reductase activity
H0H58_RS02175	COG0335	large ribosomal subunit rRNA binding
H0H58_RS02180	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H0H58_RS02190	COG0825	malonyl-CoA metabolic process
H0H58_RS02195	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H0H58_RS02200	COG1053	succinate dehydrogenase
H0H58_RS02210	COG1104	cysteine desulfurase activity
H0H58_RS02215	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H0H58_RS02220	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
H0H58_RS02235	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H0H58_RS02250	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H0H58_RS02255	COG0210	DNA helicase
H0H58_RS02260	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H0H58_RS02265	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H0H58_RS02275	COG2267	carboxylic ester hydrolase activity
H0H58_RS02280	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H0H58_RS02300	COG1181	Belongs to the D-alanine--D-alanine ligase family
H0H58_RS02305	COG0564	pseudouridine synthase activity
H0H58_RS02310	COG2239	Acts as a magnesium transporter
H0H58_RS02315	COG0495	leucyl-tRNA aminoacylation
H0H58_RS02320	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H0H58_RS02325	COG0528	UMP kinase activity
H0H58_RS02330	COG0233	cytoplasmic translational termination
H0H58_RS02335	COG0017	Asparaginyl-tRNA synthetase
H0H58_RS02340	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
H0H58_RS02345	COG1012	belongs to the aldehyde dehydrogenase family
H0H58_RS02350	COG2166	iron-sulfur cluster assembly
H0H58_RS02355	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
H0H58_RS02360	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H0H58_RS02365	COG0254	rRNA binding
H0H58_RS02370	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H0H58_RS02375	COG2226	methyltransferase
H0H58_RS02385	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H0H58_RS02395	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H0H58_RS02405	COG0149	triose-phosphate isomerase activity
H0H58_RS02420	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
H0H58_RS02425	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H0H58_RS02430	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H0H58_RS02435	COG0508	dehydrogenase complex catalyzes the overall conversion of
H0H58_RS02445	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H0H58_RS02455	COG1253	flavin adenine dinucleotide binding
H0H58_RS02470	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H0H58_RS02480	COG1187	pseudouridine synthase activity
H0H58_RS02485	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
H0H58_RS02495	COG0571	ribonuclease III activity
H0H58_RS02500	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H0H58_RS02505	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H0H58_RS02510	COG0307	riboflavin synthase, alpha
H0H58_RS02525	COG0196	riboflavin kinase activity
H0H58_RS02535	COG0473	3-isopropylmalate dehydrogenase activity
H0H58_RS02545	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H0H58_RS02550	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H0H58_RS02560	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H0H58_RS02565	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H0H58_RS02570	COG0542	response to heat
H0H58_RS02575	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
H0H58_RS02585	COG1028	Short-chain dehydrogenase reductase Sdr
H0H58_RS02590	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
H0H58_RS02595	COG2949	membrane
H0H58_RS02600	COG0653	protein targeting
H0H58_RS02610	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H0H58_RS02620	COG0259	pyridoxamine-phosphate oxidase activity
H0H58_RS02630	COG0072	phenylalanine-tRNA ligase activity
H0H58_RS02630	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H0H58_RS02635	COG0423	glycine-tRNA ligase activity
H0H58_RS02640	COG0492	ferredoxin-NADP+ reductase activity
H0H58_RS02655	COG0481	GTPase activity
H0H58_RS02665	COG0193	aminoacyl-tRNA hydrolase activity
H0H58_RS02670	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
H0H58_RS02675	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
H0H58_RS02675	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H0H58_RS02680	COG0230	Belongs to the bacterial ribosomal protein bL34 family
H0H58_RS02695	COG1234	tRNA 3'-trailer cleavage
H0H58_RS02715	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H0H58_RS02720	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H0H58_RS02725	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H0H58_RS02730	COG0719	Fe-S assembly protein
H0H58_RS02735	COG0396	ATPase activity
H0H58_RS02740	COG0719	Fe-S assembly protein
H0H58_RS02745	COG0316	Belongs to the HesB IscA family
H0H58_RS02750	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
H0H58_RS02760	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H0H58_RS02765	COG0596	Alpha beta hydrolase
H0H58_RS02770	COG0668	transmembrane transport