locus-tag	class	description
H0H76_RS00005	COG0195	Participates in both transcription termination and antitermination
H0H76_RS00010	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
H0H76_RS00015	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H0H76_RS00025	COG0508	dehydrogenase complex catalyzes the overall conversion of
H0H76_RS00030	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H0H76_RS00035	COG0815	Transfers the fatty acyl group on membrane lipoproteins
H0H76_RS00045	COG0772	Belongs to the SEDS family
H0H76_RS00050	COG0768	penicillin binding
H0H76_RS00065	COG1077	Cell shape determining protein MreB Mrl
H0H76_RS00070	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H0H76_RS00075	COG0251	oxidation-reduction process
H0H76_RS00080	COG0101	tRNA pseudouridine synthase activity
H0H76_RS00085	COG1132	(ABC) transporter
H0H76_RS00100	COG0039	L-malate dehydrogenase activity
H0H76_RS00105	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H0H76_RS00105	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H0H76_RS00110	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H0H76_RS00115	COG1522	sequence-specific DNA binding
H0H76_RS00120	COG1480	7TM receptor with intracellular HD hydrolase
H0H76_RS00160	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H0H76_RS00170	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H0H76_RS00175	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
H0H76_RS00175	COG0321	lipoyl(octanoyl) transferase activity
H0H76_RS00180	COG1333	cytochrome c biogenesis protein
H0H76_RS00180	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H0H76_RS00190	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H0H76_RS00200	COG0508	dehydrogenase complex catalyzes the overall conversion of
H0H76_RS00215	COG0045	succinate-CoA ligase (ADP-forming) activity
H0H76_RS00235	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H0H76_RS00250	COG2151	metal-sulfur cluster biosynthetic enzyme
H0H76_RS00260	COG0612	Peptidase, M16
H0H76_RS00300	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H0H76_RS00305	COG1214	PFAM Peptidase M22, glycoprotease
H0H76_RS00310	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H0H76_RS00315	COG0215	cysteine-tRNA ligase activity
H0H76_RS00320	COG0626	cystathionine gamma-synthase activity
H0H76_RS00325	COG0356	it plays a direct role in the translocation of protons across the membrane
H0H76_RS00330	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H0H76_RS00335	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H0H76_RS00340	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H0H76_RS00350	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
H0H76_RS00355	COG0180	Tryptophanyl-tRNA synthetase
H0H76_RS00360	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H0H76_RS00365	COG0484	heat shock protein binding
H0H76_RS00370	COG0482	sulfurtransferase activity
H0H76_RS00375	COG0129	dihydroxy-acid dehydratase activity
H0H76_RS00380	COG0028	Belongs to the TPP enzyme family
H0H76_RS00385	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
H0H76_RS00390	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H0H76_RS00400	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
H0H76_RS00405	COG0681	Belongs to the peptidase S26 family
H0H76_RS00415	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H0H76_RS00430	COG0776	regulation of translation
H0H76_RS00455	COG0084	hydrolase, TatD family'
H0H76_RS00485	COG1183	phosphatidylcholine synthase activity
H0H76_RS00500	COG0552	protein localization to endoplasmic reticulum
H0H76_RS00510	COG0267	Belongs to the bacterial ribosomal protein bL33 family
H0H76_RS00515	COG0227	Belongs to the bacterial ribosomal protein bL28 family
H0H76_RS00520	COG0217	transcriptional regulatory protein
H0H76_RS00555	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H0H76_RS00560	COG0439	Biotin carboxylase
H0H76_RS00565	COG0511	ligase activity, forming carbon-carbon bonds
H0H76_RS00570	COG0333	Belongs to the bacterial ribosomal protein bL32 family
H0H76_RS00575	COG0442	prolyl-tRNA aminoacylation
H0H76_RS00580	COG0167	dihydroorotate dehydrogenase activity
H0H76_RS00585	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H0H76_RS00590	COG2095	MarC family integral membrane protein
H0H76_RS00605	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
H0H76_RS00615	COG0328	RNA-DNA hybrid ribonuclease activity
H0H76_RS00620	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H0H76_RS00635	COG0804	urea catabolic process
H0H76_RS00640	COG0832	Belongs to the urease beta subunit family
H0H76_RS00640	COG0831	urea catabolic process
H0H76_RS00645	COG0527	aspartate kinase activity
H0H76_RS00645	COG0460	homoserine dehydrogenase
H0H76_RS00650	COG0083	homoserine kinase activity
H0H76_RS00655	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H0H76_RS00660	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
H0H76_RS00665	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H0H76_RS00670	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
H0H76_RS00680	COG0586	Pfam SNARE associated Golgi protein
H0H76_RS00685	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
H0H76_RS00690	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H0H76_RS00695	COG2255	four-way junction helicase activity
H0H76_RS00700	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H0H76_RS00710	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H0H76_RS00715	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
H0H76_RS00720	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H0H76_RS00725	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
H0H76_RS00730	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H0H76_RS00740	COG0138	bifunctional purine biosynthesis protein purh
H0H76_RS00745	COG0151	Belongs to the GarS family
H0H76_RS00750	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H0H76_RS00750	COG0519	Catalyzes the synthesis of GMP from XMP
H0H76_RS00755	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H0H76_RS00760	COG0191	fructose-bisphosphate aldolase activity
H0H76_RS00765	COG1074	ATP-dependent DNA helicase activity
H0H76_RS00770	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H0H76_RS00775	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
H0H76_RS00790	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
H0H76_RS00795	COG0617	tRNA 3'-terminal CCA addition
H0H76_RS00805	COG2171	N-acyltransferase activity
H0H76_RS00810	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H0H76_RS00820	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
H0H76_RS00830	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
H0H76_RS00835	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H0H76_RS00840	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
H0H76_RS00845	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
H0H76_RS00850	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
H0H76_RS00855	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H0H76_RS00860	COG0018	arginyl-trna synthetase
H0H76_RS00865	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H0H76_RS00880	COG1704	LemA family
H0H76_RS00890	COG0525	valine-tRNA ligase activity
H0H76_RS00895	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
H0H76_RS00910	COG0508	dehydrogenase complex catalyzes the overall conversion of
H0H76_RS00910	COG0022	dehydrogenase e1 component
H0H76_RS00915	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
H0H76_RS00920	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H0H76_RS00925	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H0H76_RS00930	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H0H76_RS00935	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H0H76_RS00935	COG0140	phosphoribosyl-ATP diphosphatase activity
H0H76_RS00940	COG0107	imidazoleglycerol-phosphate synthase activity
H0H76_RS00945	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
H0H76_RS00950	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H0H76_RS00955	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
H0H76_RS00955	COG0131	Imidazoleglycerol-phosphate dehydratase
H0H76_RS00960	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H0H76_RS00965	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H0H76_RS00970	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H0H76_RS00975	COG0708	Exodeoxyribonuclease III
H0H76_RS00985	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H0H76_RS00995	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
H0H76_RS01005	COG0133	tryptophan synthase activity
H0H76_RS01010	COG0135	phosphoribosylanthranilate isomerase activity
H0H76_RS01020	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H0H76_RS01025	COG0512	Glutamine amidotransferase of anthranilate synthase
H0H76_RS01025	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H0H76_RS01030	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H0H76_RS01035	COG0509	glycine decarboxylation via glycine cleavage system
H0H76_RS01040	COG2217	Heavy metal translocating P-type atpase
H0H76_RS01055	COG2010	Cytochrome c
H0H76_RS01070	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H0H76_RS01075	COG0268	Binds directly to 16S ribosomal RNA
H0H76_RS01090	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H0H76_RS01100	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
H0H76_RS01110	COG0805	protein transport
H0H76_RS01115	COG0012	GTP binding
H0H76_RS01120	COG1363	Peptidase, m42
H0H76_RS01125	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
H0H76_RS01130	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H0H76_RS01145	COG0768	penicillin binding
H0H76_RS01150	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H0H76_RS01155	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H0H76_RS01160	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H0H76_RS01165	COG0772	Belongs to the SEDS family
H0H76_RS01170	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H0H76_RS01175	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H0H76_RS01190	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H0H76_RS01195	COG0124	histidyl-tRNA synthetase
H0H76_RS01210	COG0489	protein tyrosine kinase activity
H0H76_RS01215	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
H0H76_RS01220	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H0H76_RS01235	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H0H76_RS01255	COG0632	four-way junction helicase activity
H0H76_RS01265	COG0336	Belongs to the RNA methyltransferase TrmD family
H0H76_RS01270	COG0165	Argininosuccinate lyase
H0H76_RS01275	COG0187	DNA topoisomerase II activity
H0H76_RS01280	COG1968	undecaprenyl-diphosphatase activity
H0H76_RS01285	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H0H76_RS01290	COG0228	four-way junction DNA binding
H0H76_RS01300	COG1301	dicarboxylic acid transport
H0H76_RS01320	COG0357	Ribosomal RNA small subunit methyltransferase G
H0H76_RS01325	COG0402	S-adenosylhomocysteine deaminase activity
H0H76_RS01330	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
H0H76_RS01335	COG0321	lipoyl(octanoyl) transferase activity
H0H76_RS01340	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H0H76_RS01345	COG0450	alkyl hydroperoxide reductase
H0H76_RS01350	COG0358	DNA primase activity
H0H76_RS01355	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H0H76_RS01360	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H0H76_RS01365	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H0H76_RS01370	COG2877	3-deoxy-8-phosphooctulonate synthase activity
H0H76_RS01375	COG0287	Prephenate dehydrogenase
H0H76_RS01385	COG1605	Chorismate mutase
H0H76_RS01385	COG0077	Prephenate dehydratase
H0H76_RS01390	COG1914	H( )-stimulated, divalent metal cation uptake system
H0H76_RS01395	COG0359	binds to the 23S rRNA
H0H76_RS01405	COG0360	Binds together with S18 to 16S ribosomal RNA
H0H76_RS01410	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H0H76_RS01415	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
H0H76_RS01420	COG2890	protein-(glutamine-N5) methyltransferase activity
H0H76_RS01425	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H0H76_RS01445	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H0H76_RS01445	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H0H76_RS01450	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H0H76_RS01450	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H0H76_RS01465	COG1674	ftsk spoiiie
H0H76_RS01475	COG3118	belongs to the thioredoxin family
H0H76_RS01485	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H0H76_RS01495	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H0H76_RS01500	COG0505	Belongs to the CarA family
H0H76_RS01505	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H0H76_RS01515	COG0137	argininosuccinate synthase activity
H0H76_RS01525	COG0539	negative regulation of cytoplasmic translation
H0H76_RS01530	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H0H76_RS01530	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H0H76_RS01570	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H0H76_RS01575	COG0142	geranyltranstransferase activity
H0H76_RS01580	COG1754	DNA topoisomerase type I activity
H0H76_RS01580	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H0H76_RS01590	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
H0H76_RS01595	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H0H76_RS01600	COG0194	GDP metabolic process
H0H76_RS01610	COG0698	ribose 5-phosphate isomerase
H0H76_RS01615	COG0126	phosphoglycerate kinase activity
H0H76_RS01620	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H0H76_RS01640	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H0H76_RS01645	COG0297	glycogen (starch) synthase activity
H0H76_RS01650	COG0557	exoribonuclease II activity
H0H76_RS01655	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H0H76_RS01660	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
H0H76_RS01675	COG1045	serine acetyltransferase
H0H76_RS01680	COG0538	isocitrate dehydrogenase activity
H0H76_RS01695	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
H0H76_RS01700	COG1575	Belongs to the MenA family. Type 1 subfamily
H0H76_RS01705	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
H0H76_RS01720	COG0148	phosphopyruvate hydratase activity
H0H76_RS01725	COG0203	ribosomal protein L17
H0H76_RS01730	COG0202	RNA polymerase activity
H0H76_RS01735	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
H0H76_RS01750	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H0H76_RS01755	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
H0H76_RS01760	COG0201	protein transport
H0H76_RS01765	COG0200	Binds to the 23S rRNA
H0H76_RS01775	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
H0H76_RS01785	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H0H76_RS01790	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
H0H76_RS01805	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
H0H76_RS01810	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
H0H76_RS01825	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
H0H76_RS01830	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
H0H76_RS01835	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H0H76_RS01840	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H0H76_RS01850	COG0088	Forms part of the polypeptide exit tunnel
H0H76_RS01860	COG0051	transcription antitermination factor activity, RNA binding
H0H76_RS01885	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
H0H76_RS01890	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H0H76_RS01895	COG0052	Belongs to the universal ribosomal protein uS2 family
H0H76_RS01900	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H0H76_RS01905	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H0H76_RS01915	COG0688	phosphatidylethanolamine metabolic process
H0H76_RS01930	COG0799	negative regulation of ribosome biogenesis
H0H76_RS01935	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
H0H76_RS01935	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
H0H76_RS01940	COG0706	membrane insertase activity
H0H76_RS01945	COG0504	CTP synthase activity
H0H76_RS01950	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
H0H76_RS01960	COG0563	adenylate kinase activity
H0H76_RS01965	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H0H76_RS01970	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H0H76_RS01985	COG1528	Iron-storage protein
H0H76_RS01995	COG0724	RNA recognition motif
H0H76_RS02000	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
H0H76_RS02020	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
H0H76_RS02040	COG1132	(ABC) transporter
H0H76_RS02045	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H0H76_RS02065	COG1252	NADH dehydrogenase
H0H76_RS02080	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
H0H76_RS02085	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H0H76_RS02115	COG0285	dihydrofolate synthase activity
H0H76_RS02120	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H0H76_RS02125	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H0H76_RS02130	COG0085	RNA polymerase activity
H0H76_RS02135	COG0222	ribosome binding
H0H76_RS02140	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H0H76_RS02145	COG0081	regulation of translation
H0H76_RS02195	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
H0H76_RS02200	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H0H76_RS02205	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
H0H76_RS02220	COG0517	IMP dehydrogenase activity
H0H76_RS02220	COG0516	GMP reductase activity
H0H76_RS02230	COG0335	large ribosomal subunit rRNA binding
H0H76_RS02235	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H0H76_RS02240	COG0305	Participates in initiation and elongation during chromosome replication
H0H76_RS02245	COG0825	malonyl-CoA metabolic process
H0H76_RS02250	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H0H76_RS02255	COG1053	succinate dehydrogenase
H0H76_RS02265	COG1104	cysteine desulfurase activity
H0H76_RS02270	COG1418	mRNA catabolic process
H0H76_RS02275	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H0H76_RS02285	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
H0H76_RS02290	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H0H76_RS02300	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H0H76_RS02315	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H0H76_RS02320	COG0210	DNA helicase
H0H76_RS02335	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H0H76_RS02340	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H0H76_RS02350	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
H0H76_RS02355	COG2267	carboxylic ester hydrolase activity
H0H76_RS02360	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H0H76_RS02365	COG0750	zinc metalloprotease
H0H76_RS02380	COG1181	Belongs to the D-alanine--D-alanine ligase family
H0H76_RS02395	COG2239	Acts as a magnesium transporter
H0H76_RS02400	COG0495	leucyl-tRNA aminoacylation
H0H76_RS02405	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H0H76_RS02410	COG0528	UMP kinase activity
H0H76_RS02415	COG0233	cytoplasmic translational termination
H0H76_RS02420	COG0017	Asparaginyl-tRNA synthetase
H0H76_RS02430	COG2166	iron-sulfur cluster assembly
H0H76_RS02435	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
H0H76_RS02445	COG0254	rRNA binding
H0H76_RS02455	COG2226	methyltransferase
H0H76_RS02465	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H0H76_RS02475	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H0H76_RS02485	COG0149	triose-phosphate isomerase activity
H0H76_RS02495	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H0H76_RS02505	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H0H76_RS02510	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H0H76_RS02515	COG0508	dehydrogenase complex catalyzes the overall conversion of
H0H76_RS02525	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H0H76_RS02545	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H0H76_RS02550	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H0H76_RS02555	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H0H76_RS02565	COG1187	pseudouridine synthase activity
H0H76_RS02570	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
H0H76_RS02575	COG0218	Necessary for normal cell division and for the maintenance of normal septation
H0H76_RS02585	COG0571	ribonuclease III activity
H0H76_RS02590	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H0H76_RS02595	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H0H76_RS02610	COG0196	riboflavin kinase activity
H0H76_RS02620	COG0473	3-isopropylmalate dehydrogenase activity
H0H76_RS02625	COG0066	3-isopropylmalate dehydratase activity
H0H76_RS02630	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H0H76_RS02635	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H0H76_RS02645	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H0H76_RS02650	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H0H76_RS02655	COG0542	response to heat
H0H76_RS02660	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
H0H76_RS02665	COG1166	arginine decarboxylase activity
H0H76_RS02670	COG0010	Belongs to the arginase family
H0H76_RS02675	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
H0H76_RS02680	COG1028	Short-chain dehydrogenase reductase Sdr
H0H76_RS02685	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
H0H76_RS02690	COG2949	membrane
H0H76_RS02695	COG0653	protein targeting
H0H76_RS02705	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H0H76_RS02710	COG0776	regulation of translation
H0H76_RS02715	COG0259	pyridoxamine-phosphate oxidase activity
H0H76_RS02730	COG0423	glycine-tRNA ligase activity
H0H76_RS02735	COG0492	ferredoxin-NADP+ reductase activity
H0H76_RS02745	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H0H76_RS02750	COG0481	GTPase activity
H0H76_RS02760	COG0193	aminoacyl-tRNA hydrolase activity
H0H76_RS02765	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
H0H76_RS02770	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H0H76_RS02770	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
H0H76_RS02790	COG1234	tRNA 3'-trailer cleavage
H0H76_RS02810	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H0H76_RS02815	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H0H76_RS02820	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H0H76_RS02830	COG0396	ATPase activity
H0H76_RS02835	COG0719	Fe-S assembly protein
H0H76_RS02840	COG0316	Belongs to the HesB IscA family
H0H76_RS02850	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
H0H76_RS02855	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
H0H76_RS02860	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H0H76_RS02870	COG0668	transmembrane transport