locus-tag	class	description
DM803_RS00005	COG1077	Cell shape determining protein MreB Mrl
DM803_RS00020	COG0768	penicillin binding
DM803_RS00025	COG0772	Belongs to the SEDS family
DM803_RS00030	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DM803_RS00040	COG0815	Transfers the fatty acyl group on membrane lipoproteins
DM803_RS00045	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
DM803_RS00045	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DM803_RS00050	COG0508	dehydrogenase complex catalyzes the overall conversion of
DM803_RS00055	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
DM803_RS00060	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DM803_RS00065	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DM803_RS00070	COG0195	Participates in both transcription termination and antitermination
DM803_RS00075	COG0668	transmembrane transport
DM803_RS00080	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
DM803_RS00100	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DM803_RS00110	COG0316	Belongs to the HesB IscA family
DM803_RS00115	COG0719	Fe-S assembly protein
DM803_RS00120	COG0396	ATPase activity
DM803_RS00125	COG0719	Fe-S assembly protein
DM803_RS00130	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DM803_RS00135	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DM803_RS00140	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DM803_RS00165	COG1234	tRNA 3'-trailer cleavage
DM803_RS00190	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
DM803_RS00190	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DM803_RS00205	COG0193	aminoacyl-tRNA hydrolase activity
DM803_RS00210	COG0481	GTPase activity
DM803_RS00225	COG0492	ferredoxin-NADP+ reductase activity
DM803_RS00230	COG0423	glycine-tRNA ligase activity
DM803_RS00250	COG0259	pyridoxamine-phosphate oxidase activity
DM803_RS00255	COG0776	regulation of translation
DM803_RS00260	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DM803_RS00270	COG0653	protein targeting
DM803_RS00275	COG2949	membrane
DM803_RS00280	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
DM803_RS00285	COG1028	Short-chain dehydrogenase reductase Sdr
DM803_RS00290	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DM803_RS00295	COG0010	Belongs to the arginase family
DM803_RS00305	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
DM803_RS00310	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DM803_RS00315	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DM803_RS00330	COG0196	riboflavin kinase activity
DM803_RS00345	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
DM803_RS00350	COG0307	riboflavin synthase, alpha
DM803_RS00355	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
DM803_RS00360	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DM803_RS00365	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DM803_RS00370	COG0571	ribonuclease III activity
DM803_RS00380	COG0218	Necessary for normal cell division and for the maintenance of normal septation
DM803_RS00385	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
DM803_RS00390	COG1187	pseudouridine synthase activity
DM803_RS00400	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DM803_RS00410	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DM803_RS00430	COG1253	flavin adenine dinucleotide binding
DM803_RS00440	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DM803_RS00445	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DM803_RS00445	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DM803_RS00450	COG1132	(ABC) transporter
DM803_RS00455	COG0861	Integral membrane protein TerC family
DM803_RS00460	COG0508	dehydrogenase complex catalyzes the overall conversion of
DM803_RS00465	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DM803_RS00470	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DM803_RS00480	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DM803_RS00490	COG0149	triose-phosphate isomerase activity
DM803_RS00500	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DM803_RS00510	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DM803_RS00525	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DM803_RS00530	COG0254	rRNA binding
DM803_RS00535	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DM803_RS00545	COG2166	iron-sulfur cluster assembly
DM803_RS00550	COG1012	belongs to the aldehyde dehydrogenase family
DM803_RS00555	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
DM803_RS00560	COG0017	Asparaginyl-tRNA synthetase
DM803_RS00565	COG0233	cytoplasmic translational termination
DM803_RS00570	COG0528	UMP kinase activity
DM803_RS00575	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DM803_RS00580	COG0495	leucyl-tRNA aminoacylation
DM803_RS00585	COG2239	Acts as a magnesium transporter
DM803_RS00590	COG0564	pseudouridine synthase activity
DM803_RS00600	COG1181	Belongs to the D-alanine--D-alanine ligase family
DM803_RS00615	COG0750	zinc metalloprotease
DM803_RS00630	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
DM803_RS00640	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DM803_RS00650	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DM803_RS00665	COG0210	DNA helicase
DM803_RS00670	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DM803_RS00690	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DM803_RS00690	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DM803_RS00695	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
DM803_RS00700	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DM803_RS00710	COG1418	mRNA catabolic process
DM803_RS00715	COG1104	cysteine desulfurase activity
DM803_RS00725	COG1053	succinate dehydrogenase
DM803_RS00730	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DM803_RS00735	COG0825	malonyl-CoA metabolic process
DM803_RS00740	COG0305	Participates in initiation and elongation during chromosome replication
DM803_RS00750	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DM803_RS00755	COG0335	large ribosomal subunit rRNA binding
DM803_RS00765	COG0516	GMP reductase activity
DM803_RS00765	COG0517	IMP dehydrogenase activity
DM803_RS00780	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
DM803_RS00795	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DM803_RS00845	COG0081	regulation of translation
DM803_RS00850	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DM803_RS00855	COG0222	ribosome binding
DM803_RS00860	COG0085	RNA polymerase activity
DM803_RS00865	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DM803_RS00875	COG0285	dihydrofolate synthase activity
DM803_RS00885	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DM803_RS00900	COG0534	Mate efflux family protein
DM803_RS00905	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DM803_RS00930	COG1252	NADH dehydrogenase
DM803_RS00935	COG2738	Putative neutral zinc metallopeptidase
DM803_RS00945	COG0237	dephospho-CoA kinase activity
DM803_RS00950	COG1862	Preprotein translocase
DM803_RS00955	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DM803_RS00960	COG1132	(ABC) transporter
DM803_RS00980	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DM803_RS01005	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
DM803_RS01010	COG0724	RNA recognition motif
DM803_RS01020	COG1528	Iron-storage protein
DM803_RS01035	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DM803_RS01040	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DM803_RS01045	COG0563	adenylate kinase activity
DM803_RS01055	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DM803_RS01060	COG0504	CTP synthase activity
DM803_RS01065	COG0706	membrane insertase activity
DM803_RS01070	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
DM803_RS01070	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
DM803_RS01075	COG0799	negative regulation of ribosome biogenesis
DM803_RS01085	COG4589	Belongs to the CDS family
DM803_RS01090	COG0688	phosphatidylethanolamine metabolic process
DM803_RS01100	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DM803_RS01105	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DM803_RS01110	COG0052	Belongs to the universal ribosomal protein uS2 family
DM803_RS01115	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DM803_RS01120	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
DM803_RS01145	COG0051	transcription antitermination factor activity, RNA binding
DM803_RS01150	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DM803_RS01155	COG0088	Forms part of the polypeptide exit tunnel
DM803_RS01160	COG0089	rRNA binding
DM803_RS01170	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DM803_RS01175	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DM803_RS01180	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DM803_RS01185	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DM803_RS01195	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DM803_RS01205	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DM803_RS01215	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DM803_RS01220	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DM803_RS01230	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
DM803_RS01240	COG0200	Binds to the 23S rRNA
DM803_RS01245	COG0201	protein transport
DM803_RS01250	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DM803_RS01255	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DM803_RS01270	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DM803_RS01275	COG0202	RNA polymerase activity
DM803_RS01280	COG0203	ribosomal protein L17
DM803_RS01285	COG0148	phosphopyruvate hydratase activity
DM803_RS01290	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
DM803_RS01300	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
DM803_RS01305	COG1575	Belongs to the MenA family. Type 1 subfamily
DM803_RS01310	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
DM803_RS01325	COG0538	isocitrate dehydrogenase activity
DM803_RS01345	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DM803_RS01350	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DM803_RS01360	COG1774	PSP1 C-terminal conserved region
DM803_RS01365	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DM803_RS01370	COG0557	exoribonuclease II activity
DM803_RS01375	COG0297	glycogen (starch) synthase activity
DM803_RS01380	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DM803_RS01410	COG0126	phosphoglycerate kinase activity
DM803_RS01415	COG0698	ribose 5-phosphate isomerase
DM803_RS01425	COG0194	GDP metabolic process
DM803_RS01430	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DM803_RS01435	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
DM803_RS01445	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DM803_RS01455	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
DM803_RS01485	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DM803_RS01500	COG0137	argininosuccinate synthase activity
DM803_RS01510	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DM803_RS01515	COG0505	Belongs to the CarA family
DM803_RS01525	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DM803_RS01530	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DM803_RS01535	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DM803_RS01540	COG3118	belongs to the thioredoxin family
DM803_RS01550	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DM803_RS01550	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DM803_RS01560	COG1674	ftsk spoiiie
DM803_RS01575	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DM803_RS01575	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DM803_RS01580	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DM803_RS01580	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DM803_RS01600	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DM803_RS01605	COG2890	protein-(glutamine-N5) methyltransferase activity
DM803_RS01610	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DM803_RS01615	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DM803_RS01620	COG0360	Binds together with S18 to 16S ribosomal RNA
DM803_RS01630	COG0359	binds to the 23S rRNA
DM803_RS01635	COG1914	H( )-stimulated, divalent metal cation uptake system
DM803_RS01645	COG0436	Aminotransferase
DM803_RS01650	COG0287	Prephenate dehydrogenase
DM803_RS01655	COG0077	Prephenate dehydratase
DM803_RS01655	COG1605	Chorismate mutase
DM803_RS01660	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DM803_RS01665	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
DM803_RS01670	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DM803_RS01675	COG0358	DNA primase activity
DM803_RS01680	COG0450	alkyl hydroperoxide reductase
DM803_RS01685	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DM803_RS01690	COG0321	lipoyl(octanoyl) transferase activity
DM803_RS01695	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DM803_RS01700	COG0402	S-adenosylhomocysteine deaminase activity
DM803_RS01705	COG0357	Ribosomal RNA small subunit methyltransferase G
DM803_RS01710	COG0436	Aminotransferase
DM803_RS01725	COG1301	dicarboxylic acid transport
DM803_RS01735	COG0228	four-way junction DNA binding
DM803_RS01740	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DM803_RS01750	COG0187	DNA topoisomerase II activity
DM803_RS01755	COG0336	Belongs to the RNA methyltransferase TrmD family
DM803_RS01765	COG0632	four-way junction helicase activity
DM803_RS01785	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DM803_RS01790	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DM803_RS01805	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DM803_RS01810	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
DM803_RS01815	COG0489	protein tyrosine kinase activity
DM803_RS01825	COG3201	nicotinamide mononucleotide transporter
DM803_RS01830	COG0124	histidyl-tRNA synthetase
DM803_RS01835	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DM803_RS01850	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DM803_RS01855	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DM803_RS01860	COG0772	Belongs to the SEDS family
DM803_RS01865	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DM803_RS01870	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DM803_RS01875	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DM803_RS01880	COG0768	penicillin binding
DM803_RS01900	COG0756	dUTP diphosphatase activity
DM803_RS01925	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DM803_RS01930	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
DM803_RS01935	COG1363	Peptidase, m42
DM803_RS01940	COG0012	GTP binding
DM803_RS01945	COG0805	protein transport
DM803_RS01950	COG2885	chlorophyll binding
DM803_RS01955	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DM803_RS01960	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DM803_RS01965	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DM803_RS01970	COG1694	Mazg nucleotide pyrophosphohydrolase
DM803_RS01980	COG0791	NLP P60 protein
DM803_RS01990	COG0268	Binds directly to 16S ribosomal RNA
DM803_RS01995	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DM803_RS02030	COG2217	Heavy metal translocating P-type atpase
DM803_RS02035	COG0509	glycine decarboxylation via glycine cleavage system
DM803_RS02045	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DM803_RS02050	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
DM803_RS02060	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DM803_RS02070	COG0708	Exodeoxyribonuclease III
DM803_RS02075	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DM803_RS02080	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DM803_RS02085	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DM803_RS02090	COG0131	Imidazoleglycerol-phosphate dehydratase
DM803_RS02090	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
DM803_RS02095	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DM803_RS02100	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DM803_RS02105	COG0107	imidazoleglycerol-phosphate synthase activity
DM803_RS02110	COG0140	phosphoribosyl-ATP diphosphatase activity
DM803_RS02110	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DM803_RS02115	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DM803_RS02120	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DM803_RS02125	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DM803_RS02135	COG0022	dehydrogenase e1 component
DM803_RS02135	COG0508	dehydrogenase complex catalyzes the overall conversion of
DM803_RS02150	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DM803_RS02155	COG0525	valine-tRNA ligase activity
DM803_RS02165	COG1704	LemA family
DM803_RS02170	COG0105	UTP biosynthetic process
DM803_RS02180	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DM803_RS02185	COG0018	arginyl-trna synthetase
DM803_RS02190	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DM803_RS02195	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DM803_RS02205	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DM803_RS02210	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DM803_RS02215	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DM803_RS02225	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
DM803_RS02235	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DM803_RS02240	COG2171	N-acyltransferase activity
DM803_RS02245	COG0009	L-threonylcarbamoyladenylate synthase
DM803_RS02250	COG0517	IMP dehydrogenase activity
DM803_RS02250	COG0617	tRNA 3'-terminal CCA addition
DM803_RS02250	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
DM803_RS02255	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
DM803_RS02270	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DM803_RS02275	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DM803_RS02290	COG0191	fructose-bisphosphate aldolase activity
DM803_RS02295	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
DM803_RS02300	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DM803_RS02300	COG0519	Catalyzes the synthesis of GMP from XMP
DM803_RS02305	COG0151	Belongs to the GarS family
DM803_RS02310	COG0138	bifunctional purine biosynthesis protein purh
DM803_RS02325	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
DM803_RS02330	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DM803_RS02340	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DM803_RS02345	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DM803_RS02350	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DM803_RS02355	COG2255	four-way junction helicase activity
DM803_RS02360	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
DM803_RS02365	COG0793	Belongs to the peptidase S41A family
DM803_RS02370	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DM803_RS02375	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DM803_RS02380	COG0586	Pfam SNARE associated Golgi protein
DM803_RS02390	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DM803_RS02395	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DM803_RS02410	COG0831	urea catabolic process
DM803_RS02410	COG0832	Belongs to the urease beta subunit family
DM803_RS02430	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DM803_RS02435	COG0328	RNA-DNA hybrid ribonuclease activity
DM803_RS02445	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
DM803_RS02460	COG2095	MarC family integral membrane protein
DM803_RS02465	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DM803_RS02470	COG0167	dihydroorotate dehydrogenase activity
DM803_RS02480	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DM803_RS02485	COG0511	ligase activity, forming carbon-carbon bonds
DM803_RS02490	COG0439	Biotin carboxylase
DM803_RS02495	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DM803_RS02530	COG0217	transcriptional regulatory protein
DM803_RS02535	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DM803_RS02540	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DM803_RS02550	COG0552	protein localization to endoplasmic reticulum
DM803_RS02565	COG1183	phosphatidylcholine synthase activity
DM803_RS02595	COG0084	hydrolase, TatD family'
DM803_RS02600	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DM803_RS02620	COG1530	ribonuclease E activity
DM803_RS02625	COG0776	regulation of translation
DM803_RS02630	COG1194	a g-specific adenine glycosylase
DM803_RS02645	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DM803_RS02650	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DM803_RS02665	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DM803_RS02675	COG0482	sulfurtransferase activity
DM803_RS02680	COG0484	heat shock protein binding
DM803_RS02685	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DM803_RS02690	COG0180	Tryptophanyl-tRNA synthetase
DM803_RS02695	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DM803_RS02705	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DM803_RS02710	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DM803_RS02715	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DM803_RS02720	COG0356	it plays a direct role in the translocation of protons across the membrane
DM803_RS02725	COG0215	cysteine-tRNA ligase activity
DM803_RS02730	COG0302	gtp cyclohydrolase
DM803_RS02735	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DM803_RS02740	COG1214	PFAM Peptidase M22, glycoprotease
DM803_RS02745	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DM803_RS02785	COG0612	Peptidase, M16
DM803_RS02795	COG2151	metal-sulfur cluster biosynthetic enzyme
DM803_RS02815	COG0542	response to heat
DM803_RS02820	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DM803_RS02825	COG0045	succinate-CoA ligase (ADP-forming) activity
DM803_RS02845	COG0508	dehydrogenase complex catalyzes the overall conversion of
DM803_RS02855	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DM803_RS02865	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DM803_RS02865	COG1333	cytochrome c biogenesis protein
DM803_RS02870	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
DM803_RS02870	COG0321	lipoyl(octanoyl) transferase activity
DM803_RS02875	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DM803_RS02880	COG0741	lytic transglycosylase activity
DM803_RS02880	COG1388	LysM domain
DM803_RS02885	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DM803_RS02890	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DM803_RS02895	COG0756	dUTP diphosphatase activity
DM803_RS02925	COG1480	7TM receptor with intracellular HD hydrolase
DM803_RS02935	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DM803_RS02940	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DM803_RS02940	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DM803_RS02945	COG0039	L-malate dehydrogenase activity
DM803_RS02960	COG1137	ATPase activity
DM803_RS02965	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DM803_RS02970	COG1132	(ABC) transporter
DM803_RS02975	COG0101	tRNA pseudouridine synthase activity
DM803_RS02980	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity