locus-tag	class	description
K645_RS00015	ENOG4105DFF	Rod shape-determining protein mreb
K645_RS00030	ENOG4105CJN	penicillin-binding protein
K645_RS00035	ENOG4105CNI	cell division protein FtsW
K645_RS00040	ENOG4105CE8	Transfers the fatty acyl group on membrane lipoproteins (By similarity)
K645_RS00045	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
K645_RS00050	ENOG4105C7S	Dehydrogenase
K645_RS00055	ENOG4105F0N	pyrophosphate phospho-hydrolase
K645_RS00060	ENOG4105C9M	aspartyl-trna synthetase
K645_RS00065	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
K645_RS00070	ENOG4105CHV	Transcription elongation factor NusA
K645_RS00075	ENOG4105CUY	Mechanosensitive ion channel
K645_RS00080	ENOG4105CSZ	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity)
K645_RS00085	ENOG4105EV9	Alpha Beta Hydrolase
K645_RS00090	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
K645_RS00095	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
K645_RS00100	ENOG4107QZC	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
K645_RS00110	ENOG4108YX9	iron--sulfur cluster insertion protein erpA
K645_RS00125	ENOG4105JRK	feS assembly protein SufD
K645_RS00130	ENOG4105C9B	Cysteine desulfurase
K645_RS00135	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
K645_RS00140	ENOG4105K46	50S ribosomal protein l27
K645_RS00160	ENOG4105D60	lipoprotein releasing system transmembrane protein
K645_RS00165	ENOG4105IES	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity)
K645_RS00180	ENOG41086RW	50S ribosomal protein l34
K645_RS00190	ENOG4105C7C	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
K645_RS00195	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
K645_RS00200	ENOG4105CH8	Succinyl-CoA ligase ADP-forming subunit alpha
K645_RS00205	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
K645_RS00215	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
K645_RS00220	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
K645_RS00230	ENOG4105C3M	thioredoxin reductase
K645_RS00235	ENOG4105D9H	Catalyzes the attachment of glycine to tRNA(Gly) (By similarity)
K645_RS00240	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
K645_RS00255	ENOG4108S7T	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity)
K645_RS00265	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
K645_RS00275	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
K645_RS00285	ENOG4105C4A	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity)
K645_RS00290	ENOG4105CHR	reductase
K645_RS00295	ENOG4105CAT	Cytidine monophosphate kinase
K645_RS00300	ENOG4105CYW	agmatinase
K645_RS00310	ENOG4105CG1	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity)
K645_RS00315	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
K645_RS00325	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
K645_RS00340	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
K645_RS00345	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
K645_RS00350	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
K645_RS00355	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
K645_RS00370	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
K645_RS00380	ENOG4105CEZ	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity)
K645_RS00385	ENOG4108R6K	riboflavin synthase, subunit alpha
K645_RS00395	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
K645_RS00400	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
K645_RS00405	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
K645_RS00415	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
K645_RS00425	ENOG4105FE9	pseudouridine synthase
K645_RS00435	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
K645_RS00440	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
K645_RS00445	ENOG4105E1Z	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K645_RS00465	ENOG4105C37	(CBS) domain
K645_RS00485	ENOG4105BZ1	(ABC) transporter
K645_RS00490	ENOG4107TS3	membrane protein, TerC
K645_RS00505	ENOG4107EES	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity)
K645_RS00510	ENOG4105C8B	TIGR00159 family
K645_RS00515	ENOG4105EEI	dihydropteroate synthase
K645_RS00525	ENOG4105CP7	Triose-phosphate isomerase
K645_RS00535	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
K645_RS00545	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
K645_RS00555	ENOG4107UA9	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity)
K645_RS00560	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
K645_RS00565	ENOG4105NRA	50s ribosomal protein l31 type b
K645_RS00575	ENOG4105DSS	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity)
K645_RS00580	ENOG4105P9C	Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity)
K645_RS00590	ENOG4105DTW	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
K645_RS00595	ENOG4105C5S	asparaginyl-tRNA synthetase
K645_RS00600	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
K645_RS00605	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
K645_RS00615	ENOG4105C8T	Leucyl-tRNA synthetase
K645_RS00620	ENOG4105CJW	magnesium transporter
K645_RS00625	ENOG4105C34	Pseudouridine synthase
K645_RS00635	ENOG4105CPF	Cell wall formation (By similarity)
K645_RS00640	ENOG4105CE1	Ferrous iron transport protein b
K645_RS00650	ENOG4105DZP	Membrane-associated zinc metalloprotease
K645_RS00660	ENOG4105EV9	Alpha Beta Hydrolase
K645_RS00665	ENOG4105CGM	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity)
K645_RS00670	ENOG4105K59	histidine triad (HIT) protein
K645_RS00675	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
K645_RS00680	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
K645_RS00695	ENOG4105C4R	Atp-dependent dna helicase
K645_RS00715	ENOG4105E2X	shikimate dehydrogenase
K645_RS00720	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
K645_RS00730	ENOG4105K5D	4fe-4S ferredoxin iroN-sulfur binding
K645_RS00735	ENOG4107QN2	dihydrolipoyl dehydrogenase
K645_RS00745	ENOG4105E4Y	Endoribonuclease that initiates mRNA decay (By similarity)
K645_RS00750	ENOG4107QI6	Cysteine desulfurase
K645_RS00765	ENOG4105E33	succinate dehydrogenase
K645_RS00770	ENOG4107QM9	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity)
K645_RS00775	ENOG4105CDU	Replicative dna helicase
K645_RS00785	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
K645_RS00790	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
K645_RS00800	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
K645_RS00820	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
K645_RS00830	ENOG4107T7F	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
K645_RS00880	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
K645_RS00885	ENOG4107VNI	ribosomal protein l10
K645_RS00890	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
K645_RS00895	ENOG4107QIH	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
K645_RS00900	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
K645_RS00905	ENOG4105CX6	glutaminyL-tRNA synthetase
K645_RS00930	ENOG4107QI1	Mate efflux family protein
K645_RS00945	ENOG4108ZEY	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity)
K645_RS00950	ENOG4105KA0	thioesterase Superfamily protein
K645_RS00960	ENOG4105CEP	NADH dehydrogenase
K645_RS00975	ENOG4105VIE	preprotein translocase, subunit YajC
K645_RS00980	ENOG4105M7K	Involved in the transcription termination process (By similarity)
K645_RS00985	ENOG4105BZ1	(ABC) transporter
K645_RS01005	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
K645_RS01020	ENOG4108JUA	Transcriptional regulator
K645_RS01030	ENOG4107RH7	Nicotinate phosphoribosyltransferase
K645_RS01035	ENOG4105VFU	Rna-binding protein
K645_RS01045	ENOG41090A1	ferritin
K645_RS01060	ENOG4105CW3	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
K645_RS01065	ENOG4107QN2	dihydrolipoyl dehydrogenase
K645_RS01070	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
K645_RS01080	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
K645_RS01085	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
K645_RS01090	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
K645_RS01095	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
K645_RS01100	ENOG4105KEM	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity)
K645_RS01105	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
K645_RS01110	ENOG4105KNE	Phosphatidate cytidylyltransferase
K645_RS01115	ENOG41071I4	Phosphatidylserine decarboxylase proenzyme
K645_RS01125	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
K645_RS01130	ENOG4108UJD	30S ribosomal protein S9
K645_RS01135	ENOG4105CE9	30S ribosomal protein S2
K645_RS01140	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
K645_RS01145	ENOG4105CJI	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
K645_RS01170	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
K645_RS01180	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
K645_RS01190	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
K645_RS01195	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
K645_RS01200	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
K645_RS01205	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
K645_RS01215	ENOG4105WNB	50s ribosomal protein l29
K645_RS01225	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
K645_RS01240	ENOG4105VBI	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
K645_RS01245	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
K645_RS01250	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
K645_RS01255	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
K645_RS01270	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
K645_RS01275	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
K645_RS01280	ENOG410864M	50S ribosomal protein L36
K645_RS01285	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
K645_RS01295	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
K645_RS01300	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
K645_RS01305	ENOG4108ZT0	50S ribosomal protein l17
K645_RS01310	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
K645_RS01325	ENOG4108IPT	Naphthoate synthase
K645_RS01330	ENOG4105EIS	1,4-dihydroxy-2-naphthoate octaprenyltransferase
K645_RS01335	ENOG4107W2A	UPF0173 metal-dependent hydrolase
K645_RS01355	ENOG4105D7W	serine acetyltransferase
K645_RS01365	ENOG4107EER	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity)
K645_RS01370	ENOG4108JQ1	Dehydrogenase
K645_RS01375	ENOG4108JQC	penicillin-binding protein 1A
K645_RS01380	ENOG4105MA4	psp1 domain protein
K645_RS01385	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
K645_RS01395	ENOG4105CXW	Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity)
K645_RS01400	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
K645_RS01420	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
K645_RS01425	ENOG4105BZA	Phosphoglycerate kinase
K645_RS01445	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
K645_RS01450	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
K645_RS01470	ENOG4105EAH	synthase
K645_RS01475	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
K645_RS01505	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
K645_RS01530	ENOG4105C8Y	Acetylornithine aminotransferase
K645_RS01535	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
K645_RS01540	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
K645_RS01545	ENOG4107REN	Carbamoyltransferase
K645_RS01550	ENOG4107T6X	nag kinase
K645_RS01555	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
K645_RS01570	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
K645_RS01595	ENOG4105C2M	dna polymerase I
K645_RS01610	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
K645_RS01620	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
K645_RS01625	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
K645_RS01630	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
K645_RS01635	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
K645_RS01640	ENOG41080B9	Binds together with S18 to 16S ribosomal RNA (By similarity)
K645_RS01650	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
K645_RS01655	ENOG4105C56	H( )-stimulated, divalent metal cation uptake system (By similarity)
K645_RS01660	ENOG4105CQC	Prephenate dehydratase
K645_RS01665	ENOG4105CHM	Aminotransferase
K645_RS01675	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
K645_RS01680	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
K645_RS01685	ENOG4105CSJ	Enoyl- acyl-carrier-protein reductase NADH
K645_RS01690	ENOG4105DJV	ribulose-phosphate 3-epimerase
K645_RS01695	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
K645_RS01700	ENOG4105D3R	alkyl hydroperoxide reductase
K645_RS01705	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
K645_RS01710	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
K645_RS01715	ENOG4105CRK	lysyL-tRNA synthetase
K645_RS01725	ENOG4105D28	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
K645_RS01730	ENOG4105CHM	Aminotransferase
K645_RS01755	ENOG4105K5M	30s ribosomal protein S16
K645_RS01760	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
K645_RS01765	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
K645_RS01770	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
K645_RS01775	ENOG4105CH7	arginosuccinase
K645_RS01780	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
K645_RS01790	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
K645_RS01820	ENOG4105C2N	RNA methyltransferase TrmH family group 3
K645_RS01835	ENOG4107R0I	Cell wall formation (By similarity)
K645_RS01840	ENOG4105CB1	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity)
K645_RS01845	ENOG4105D1F	ATP-binding protein
K645_RS01855	ENOG4106Z1T	Nicotinamide Mononucleotide Transporter
K645_RS01860	ENOG4105CUT	histidyl-tRNA synthetase
K645_RS01865	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
K645_RS01880	ENOG4105DFU	Cell wall formation (By similarity)
K645_RS01890	ENOG4105CNI	cell division protein FtsW
K645_RS01895	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
K645_RS01900	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
K645_RS01905	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
K645_RS01925	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
K645_RS01935	ENOG4105C0H	protease
K645_RS01940	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
K645_RS01950	ENOG4105C3G	gtp-binding protein
K645_RS01955	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
K645_RS01960	ENOG4108ZG0	Ompa motb domain protein
K645_RS01965	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
K645_RS01970	ENOG4105CV1	Transketolase (EC 2.2.1.1)
K645_RS01975	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
K645_RS01990	ENOG4108QBX	(LipO)protein
K645_RS02000	ENOG4105RA3	Binds directly to 16S ribosomal RNA (By similarity)
K645_RS02005	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
K645_RS02010	ENOG4105C6K	Malic enzyme
K645_RS02020	ENOG4105D6P	C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity)
K645_RS02060	ENOG4105CRQ	synthase (Component I)
K645_RS02065	ENOG4105DDQ	anthranilate synthase
K645_RS02070	ENOG4108I0Q	anthranilate phosphoribosyltransferase
K645_RS02075	ENOG4105DK0	Indole-3-glycerol phosphate synthase
K645_RS02085	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
K645_RS02095	ENOG4105DFA	alanine racemase domain protein
K645_RS02100	ENOG4107QM1	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity)
K645_RS02110	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
K645_RS02120	ENOG4105CGK	Exodeoxyribonuclease III
K645_RS02125	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
K645_RS02130	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
K645_RS02135	ENOG4105CIH	Imidazole acetol-phosphate transaminase
K645_RS02140	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
K645_RS02145	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
K645_RS02155	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
K645_RS02160	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
K645_RS02165	ENOG4105EIZ	Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity)
K645_RS02170	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
K645_RS02175	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
K645_RS02180	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
K645_RS02185	ENOG4105SYT	Methylenetetrahydrofolate reductase
K645_RS02190	ENOG4105CPP	Dehydrogenase, E1 component
K645_RS02205	ENOG4108YYV	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity)
K645_RS02210	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
K645_RS02220	ENOG4108V0P	LemA family
K645_RS02225	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
K645_RS02230	ENOG4105CPP	Dehydrogenase, E1 component
K645_RS02235	ENOG4105CM2	brancheD-chain amino acid aminotransferase
K645_RS02240	ENOG4105C75	arginyL-tRNA synthetase
K645_RS02245	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
K645_RS02250	ENOG4105C6V	Glycerol-3-phosphate dehydrogenase
K645_RS02260	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
K645_RS02265	ENOG4105C22	threonyL-tRNA synthetase
K645_RS02270	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
K645_RS02275	ENOG4105VJV	50s ribosomal protein L35
K645_RS02280	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
K645_RS02295	ENOG4105DMJ	Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity)
K645_RS02300	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
K645_RS02310	ENOG4105SFS	phosphoesterase RecJ domain protein
K645_RS02325	ENOG4105EGD	dinuclear metal center protein, YbgI family
K645_RS02330	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
K645_RS02335	ENOG4107QKA	exodeoxyribonuclease V beta
K645_RS02340	ENOG4105D2N	Aldolase
K645_RS02345	ENOG4107QTG	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
K645_RS02350	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
K645_RS02355	ENOG4105C12	Phosphoribosylglycinamide synthetase
K645_RS02365	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
K645_RS02380	ENOG4105C8V	SAICAR synthetase
K645_RS02385	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
K645_RS02395	ENOG4105C83	adenylosuccinate lyase
K645_RS02400	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
K645_RS02405	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
K645_RS02410	ENOG4105CV2	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity)
K645_RS02420	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
K645_RS02435	ENOG4108Z6B	deaminase
K645_RS02440	ENOG4105KW6	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
K645_RS02445	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
K645_RS02450	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
K645_RS02455	ENOG4105D98	threonine synthase
K645_RS02460	ENOG4107RDY	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
K645_RS02465	ENOG4105CFH	Aspartokinase
K645_RS02470	ENOG4108YZ9	Urea amidohydrolase subunit gamma
K645_RS02490	ENOG4105C2N	RNA methyltransferase TrmH family group 3
K645_RS02495	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
K645_RS02505	ENOG4105CZI	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
K645_RS02510	ENOG4105EZI	multiple antibiotic resistance (MarC)-related protein
K645_RS02515	ENOG41065E1	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
K645_RS02520	ENOG4107RY0	Catalyzes the conversion of dihydroorotate to orotate (By similarity)
K645_RS02530	ENOG4105WXV	50S ribosomal protein L32
K645_RS02535	ENOG4105KM4	Acetyl-CoA carboxylase, biotin carboxyl carrier protein
K645_RS02540	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
K645_RS02545	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
K645_RS02550	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
K645_RS02560	ENOG4107QSV	RmuC domain protein
K645_RS02570	ENOG4105CDY	transcriptional regulatory protein
K645_RS02575	ENOG4105KDC	50s ribosomal protein l28
K645_RS02580	ENOG41083ND	50S ribosomal protein L33
K645_RS02590	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
K645_RS02600	ENOG4105UMD	exodeoxyribonuclease X
K645_RS02605	ENOG4106PT6	cdpdiacylglycerol-serine O-phosphatidyltransferase
K645_RS02615	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
K645_RS02625	ENOG4105C9Q	fumarate hydratase class II
K645_RS02630	ENOG4105F8V	Hydrolase, tatD family
K645_RS02655	ENOG4105C03	ribonuclease
K645_RS02660	ENOG41080YA	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
K645_RS02670	ENOG4105C37	(CBS) domain
K645_RS02680	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
K645_RS02685	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
K645_RS02695	ENOG4105C3F	Signal peptidase i
K645_RS02700	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
K645_RS02710	ENOG4105C7B	Threonine dehydratase
K645_RS02715	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
K645_RS02725	ENOG4105C7K	acetolactate synthase
K645_RS02740	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
K645_RS02745	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
K645_RS02750	ENOG4107XPB	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
K645_RS02755	ENOG4105C31	Tryptophanyl-tRNA synthetase
K645_RS02760	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
K645_RS02770	ENOG4107Z4P	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
K645_RS02775	ENOG4107Z65	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity)
K645_RS02780	ENOG4105VHG	atp synthase
K645_RS02785	ENOG4105EE4	it plays a direct role in the translocation of protons across the membrane (By similarity)
K645_RS02795	ENOG4105C28	cystathionine
K645_RS02800	ENOG4105C8N	cysteinyl-tRNA synthetase
K645_RS02805	ENOG4105EUJ	GTP cyclohydrolase i
K645_RS02810	ENOG4107RA1	nh(3)-dependent nad( ) synthetase
K645_RS02815	ENOG41072GX	Peptidase M22 Glycoprotease
K645_RS02825	ENOG4105C1A	potassium transporter peripheral membrane
K645_RS02850	ENOG4105D3S	4Fe-4S Ferredoxin, iron-sulfur binding domain protein
K645_RS02870	ENOG4105VG1	fes assembly suf system protein
K645_RS02895	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
K645_RS02900	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
K645_RS02905	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
K645_RS02920	ENOG4105C7S	Dehydrogenase
K645_RS02925	ENOG4105C7P	2-oxoglutarate dehydrogenase, E1
K645_RS02930	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
K645_RS02940	ENOG4105CRE	cytochrome C
K645_RS02945	ENOG4108H5C	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
K645_RS02950	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
K645_RS02955	ENOG4105E4C	Lytic transglycosylase catalytic
K645_RS02960	ENOG41067S4	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
K645_RS02965	ENOG4108S0S	Nucleotidyl transferase
K645_RS02970	ENOG4108Z1K	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
K645_RS03005	ENOG4108VVK	transcriptional Regulator, AsnC
K645_RS03010	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
K645_RS03015	ENOG4105CBI	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K645_RS03020	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
K645_RS03030	ENOG4108IUZ	ABC transporter
K645_RS03035	ENOG4105DBD	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity)
K645_RS03040	ENOG4105BZ1	(ABC) transporter
K645_RS03045	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
K645_RS03050	ENOG4105C8Y	Acetylornithine aminotransferase
K645_RS03100	ENOG4108Z1K	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
K645_RS03140	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
K645_RS03155	ENOG4108YZG	isomerase