locus-tag	class	description
CGC63_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CGC63_RS00010	COG0592	DNA-directed DNA polymerase activity
CGC63_RS00015	COG2501	S4 domain
CGC63_RS00025	COG0187	DNA topoisomerase II activity
CGC63_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CGC63_RS00045	COG2207	Transcriptional regulator
CGC63_RS00050	COG3250	beta-galactosidase activity
CGC63_RS00110	COG2340	Cysteine-rich secretory protein family
CGC63_RS00120	COG0534	Mate efflux family protein
CGC63_RS00130	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CGC63_RS00135	COG2873	o-acetylhomoserine
CGC63_RS00170	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CGC63_RS00180	COG2182	Extracellular solute-binding protein
CGC63_RS00195	COG0673	inositol 2-dehydrogenase activity
CGC63_RS00200	COG4409	exo-alpha-(2->6)-sialidase activity
CGC63_RS00210	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
CGC63_RS00215	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CGC63_RS00225	COG1592	Rubrerythrin
CGC63_RS00225	COG1773	rubredoxin
CGC63_RS00230	COG0735	belongs to the Fur family
CGC63_RS00235	COG1592	Rubrerythrin
CGC63_RS00235	COG1773	rubredoxin
CGC63_RS00245	COG0561	phosphatase activity
CGC63_RS00250	COG2002	toxin-antitoxin pair type II binding
CGC63_RS00255	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CGC63_RS00260	COG1876	peptidase activity
CGC63_RS00275	COG2972	Histidine kinase
CGC63_RS00280	COG2207	Transcriptional regulator
CGC63_RS00280	COG4753	response regulator
CGC63_RS00285	COG1653	transport
CGC63_RS00290	COG1175	transmembrane transport
CGC63_RS00295	COG0395	ABC-type sugar transport system, permease component
CGC63_RS00300	COG3842	ATPase activity
CGC63_RS00305	COG1175	transmembrane transport
CGC63_RS00310	COG0395	ABC-type sugar transport system, permease component
CGC63_RS00335	COG0358	DNA primase activity
CGC63_RS00405	COG0584	glycerophosphoryl diester phosphodiesterase
CGC63_RS00415	COG4464	protein tyrosine phosphatase activity
CGC63_RS00425	COG0489	protein tyrosine kinase activity
CGC63_RS00440	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CGC63_RS00455	COG1216	Glycosyl transferase, family 2
CGC63_RS00460	COG1216	Glycosyl transferase, family 2
CGC63_RS00460	COG1442	glycosyl transferase family 8
CGC63_RS00470	COG2244	polysaccharide biosynthetic process
CGC63_RS00475	COG3475	LICD family
CGC63_RS00485	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CGC63_RS00545	COG1213	nucleotidyl transferase
CGC63_RS00550	COG1213	nucleotidyl transferase
CGC63_RS00555	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CGC63_RS00560	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CGC63_RS00595	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CGC63_RS00605	COG4086	secreted protein
CGC63_RS00610	COG2357	RelA SpoT domain protein
CGC63_RS00635	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CGC63_RS00640	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CGC63_RS00645	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CGC63_RS00650	COG1376	ErfK ybiS ycfS ynhG family protein
CGC63_RS00670	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CGC63_RS00695	COG1917	Cupin 2, conserved barrel domain protein
CGC63_RS00695	COG2207	Transcriptional regulator
CGC63_RS00710	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CGC63_RS00735	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CGC63_RS00745	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CGC63_RS00755	COG1592	Rubrerythrin
CGC63_RS00775	COG2205	protein histidine kinase activity
CGC63_RS00785	COG1136	(ABC) transporter
CGC63_RS00795	COG1114	Component of the transport system for branched-chain amino acids
CGC63_RS00815	COG2738	Putative neutral zinc metallopeptidase
CGC63_RS00860	COG0058	SHG alpha-glucan phosphorylase activity
CGC63_RS00865	COG2059	Chromate
CGC63_RS00870	COG2059	Chromate
CGC63_RS00890	COG3708	Transcriptional regulator
CGC63_RS00890	COG2207	Transcriptional regulator
CGC63_RS00895	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CGC63_RS00900	COG0523	cobalamin synthesis protein
CGC63_RS00915	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CGC63_RS00930	COG1379	DNA repair
CGC63_RS00945	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CGC63_RS00955	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CGC63_RS00970	COG0582	viral genome integration into host DNA
CGC63_RS00995	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CGC63_RS01010	COG4509	Sortase family
CGC63_RS01055	COG3279	Response regulator of the LytR AlgR family
CGC63_RS01095	COG1132	(ABC) transporter
CGC63_RS01100	COG1404	Belongs to the peptidase S8 family
CGC63_RS01115	COG0535	radical SAM domain protein
CGC63_RS01160	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CGC63_RS01170	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CGC63_RS01180	COG2135	peptidase activity
CGC63_RS01255	COG0745	RESPONSE REGULATOR receiver
CGC63_RS01260	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CGC63_RS01275	COG0745	RESPONSE REGULATOR receiver
CGC63_RS01300	COG2205	protein histidine kinase activity
CGC63_RS01350	COG0741	lytic transglycosylase activity
CGC63_RS01350	COG0791	NLP P60 protein
CGC63_RS01375	COG0793	Belongs to the peptidase S41A family
CGC63_RS01385	COG1136	(ABC) transporter
CGC63_RS01465	COG1396	sequence-specific DNA binding
CGC63_RS01475	COG4974	Belongs to the 'phage' integrase family
CGC63_RS01500	COG1917	Cupin 2, conserved barrel domain protein
CGC63_RS01500	COG4977	sequence-specific DNA binding
CGC63_RS01510	COG3250	beta-galactosidase activity
CGC63_RS01545	COG4443	Transcriptional Coactivator p15 (PC4)
CGC63_RS01550	COG1475	DNA binding
CGC63_RS01605	COG2801	Transposase and inactivated derivatives
CGC63_RS01630	COG3464	Transposase
CGC63_RS01680	COG2205	protein histidine kinase activity
CGC63_RS01700	COG0252	asparaginase activity
CGC63_RS01705	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CGC63_RS01705	COG0116	Belongs to the methyltransferase superfamily
CGC63_RS01725	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CGC63_RS01735	COG1181	Belongs to the D-alanine--D-alanine ligase family
CGC63_RS01740	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CGC63_RS01745	COG1115	amino acid carrier protein
CGC63_RS01765	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CGC63_RS01770	COG1802	Transcriptional regulator
CGC63_RS01775	COG0697	spore germination
CGC63_RS01790	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CGC63_RS01805	COG0544	peptidyl-prolyl cis-trans isomerase activity
CGC63_RS01815	COG1132	(ABC) transporter
CGC63_RS01820	COG0436	Aminotransferase
CGC63_RS01830	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CGC63_RS01835	COG0622	Phosphoesterase
CGC63_RS01840	COG0116	Belongs to the methyltransferase superfamily
CGC63_RS01845	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CGC63_RS01850	COG0622	Phosphoesterase
CGC63_RS01890	COG1609	Transcriptional regulator
CGC63_RS01920	COG0732	type I restriction modification DNA specificity domain
CGC63_RS01930	COG2186	Transcriptional regulator
CGC63_RS01940	COG0281	malic enzyme
CGC63_RS01950	COG1609	Transcriptional regulator
CGC63_RS01960	COG0166	Belongs to the GPI family
CGC63_RS01980	COG3842	ATPase activity
CGC63_RS01985	COG3835	regulator
CGC63_RS01990	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CGC63_RS01995	COG0564	pseudouridine synthase activity
CGC63_RS02015	COG1269	ATP hydrolysis coupled proton transport
CGC63_RS02020	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CGC63_RS02035	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
CGC63_RS02040	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
CGC63_RS02045	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
CGC63_RS02050	COG1394	ATPase activity, coupled to movement of substances
CGC63_RS02055	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CGC63_RS02060	COG1957	nucleoside hydrolase
CGC63_RS02075	COG1129	ABC transporter
CGC63_RS02080	COG1122	ATPase activity
CGC63_RS02090	COG3459	Glycosyltransferase 36 associated
CGC63_RS02100	COG3507	Belongs to the glycosyl hydrolase 43 family
CGC63_RS02110	COG1917	Cupin 2, conserved barrel domain protein
CGC63_RS02110	COG2169	Transcriptional regulator
CGC63_RS02115	COG4209	transmembrane transport
CGC63_RS02120	COG0395	ABC-type sugar transport system, permease component
CGC63_RS02125	COG1653	transport
CGC63_RS02130	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
CGC63_RS02135	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
CGC63_RS02140	COG1028	Short-chain dehydrogenase reductase Sdr
CGC63_RS02155	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CGC63_RS02160	COG0765	amino acid transport
CGC63_RS02165	COG1126	abc transporter atp-binding protein
CGC63_RS02170	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
CGC63_RS02180	COG0628	permease
CGC63_RS02185	COG0569	domain protein
CGC63_RS02190	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CGC63_RS02195	COG2116	formate transmembrane transporter activity
CGC63_RS02200	COG1404	Belongs to the peptidase S8 family
CGC63_RS02205	COG3250	beta-galactosidase activity
CGC63_RS02225	COG4209	transmembrane transport
CGC63_RS02230	COG0395	ABC-type sugar transport system, permease component
CGC63_RS02295	COG1136	(ABC) transporter
CGC63_RS02305	COG1136	(ABC) transporter
CGC63_RS02315	COG0745	RESPONSE REGULATOR receiver
CGC63_RS02320	COG2205	protein histidine kinase activity
CGC63_RS02325	COG0598	Magnesium transport protein CorA
CGC63_RS02330	COG0700	Nucleoside recognition
CGC63_RS02340	COG4869	propanediol catabolic process
CGC63_RS02355	COG2986	histidine ammonia-lyase
CGC63_RS02360	COG2056	Na+-H+ antiporter family
CGC63_RS02370	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CGC63_RS02375	COG0534	Mate efflux family protein
CGC63_RS02380	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CGC63_RS02380	COG1328	CTP reductase activity
CGC63_RS02385	COG0475	glutathione-regulated potassium exporter activity
CGC63_RS02395	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CGC63_RS02400	COG2176	DNA-directed DNA polymerase activity
CGC63_RS02405	COG0709	Synthesizes selenophosphate from selenide and ATP
CGC63_RS02425	COG0745	RESPONSE REGULATOR receiver
CGC63_RS02430	COG1193	negative regulation of DNA recombination
CGC63_RS02435	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CGC63_RS02440	COG3481	metal-dependent phosphohydrolase, HD sub domain
CGC63_RS02445	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CGC63_RS02465	COG1151	hydroxylamine reductase activity
CGC63_RS02470	COG1141	Ferredoxin
CGC63_RS02505	COG1653	transport
CGC63_RS02510	COG1175	transmembrane transport
CGC63_RS02515	COG0395	ABC-type sugar transport system, permease component
CGC63_RS02550	COG1175	transmembrane transport
CGC63_RS02575	COG1132	(ABC) transporter
CGC63_RS02585	COG3290	protein histidine kinase activity
CGC63_RS02620	COG0860	N-Acetylmuramoyl-L-alanine amidase
CGC63_RS02625	COG0009	L-threonylcarbamoyladenylate synthase
CGC63_RS02630	COG0698	ribose 5-phosphate isomerase
CGC63_RS02645	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CGC63_RS02650	COG0617	tRNA 3'-terminal CCA addition
CGC63_RS02660	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CGC63_RS02670	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CGC63_RS02695	COG0037	tRNA processing
CGC63_RS02705	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CGC63_RS02710	COG3103	Sh3 type 3 domain protein
CGC63_RS02710	COG0366	Alpha amylase catalytic
CGC63_RS02760	COG2502	aspartate--ammonia ligase
CGC63_RS02775	COG3279	Response regulator of the LytR AlgR family
CGC63_RS02795	COG1131	(ABC) transporter
CGC63_RS02820	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CGC63_RS02820	COG2080	2 iron, 2 sulfur cluster binding
CGC63_RS02825	COG0531	amino acid
CGC63_RS02830	COG1362	aminopeptidase activity
CGC63_RS02845	COG0745	RESPONSE REGULATOR receiver
CGC63_RS02860	COG2205	protein histidine kinase activity
CGC63_RS02865	COG3645	SOS response
CGC63_RS02870	COG1342	Belongs to the UPF0251 family
CGC63_RS02875	COG0446	pyridine nucleotide-disulphide oxidoreductase
CGC63_RS02880	COG0583	DNA-binding transcription factor activity
CGC63_RS02890	COG2855	membrane
CGC63_RS02900	COG3119	arylsulfatase activity
CGC63_RS02910	COG1653	transport
CGC63_RS02915	COG4209	transmembrane transport
CGC63_RS02920	COG0395	ABC-type sugar transport system, permease component
CGC63_RS02925	COG3119	arylsulfatase activity
CGC63_RS02935	COG3119	arylsulfatase activity
CGC63_RS02945	COG3119	arylsulfatase activity
CGC63_RS02960	COG1132	(ABC) transporter
CGC63_RS02965	COG1132	(ABC) transporter
CGC63_RS02970	COG1653	transport
CGC63_RS02975	COG1175	transmembrane transport
CGC63_RS02980	COG0395	ABC-type sugar transport system, permease component
CGC63_RS02990	COG3119	arylsulfatase activity
CGC63_RS02995	COG3119	arylsulfatase activity
CGC63_RS03005	COG2972	Histidine kinase
CGC63_RS03010	COG4753	response regulator
CGC63_RS03010	COG2207	Transcriptional regulator
CGC63_RS03010	COG2207	Transcriptional regulator
CGC63_RS03010	COG4753	response regulator
CGC63_RS03015	COG1876	peptidase activity
CGC63_RS03030	COG1132	(ABC) transporter
CGC63_RS03035	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CGC63_RS03040	COG2205	protein histidine kinase activity
CGC63_RS03045	COG0745	RESPONSE REGULATOR receiver
CGC63_RS03060	COG2195	Cleaves the N-terminal amino acid of tripeptides
CGC63_RS03065	COG1380	Effector of murein hydrolase LrgA
CGC63_RS03070	COG1346	cytolysis
CGC63_RS03075	COG2186	Transcriptional regulator
CGC63_RS03080	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CGC63_RS03090	COG0366	Alpha amylase catalytic
CGC63_RS03095	COG2207	Transcriptional regulator
CGC63_RS03095	COG1917	Cupin 2, conserved barrel domain protein
CGC63_RS03105	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CGC63_RS03110	COG4684	Psort location CytoplasmicMembrane, score
CGC63_RS03115	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CGC63_RS03125	COG4509	Sortase family
CGC63_RS03140	COG0360	Binds together with S18 to 16S ribosomal RNA
CGC63_RS03145	COG0629	single-stranded DNA binding
CGC63_RS03150	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CGC63_RS03155	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
CGC63_RS03160	COG0359	binds to the 23S rRNA
CGC63_RS03165	COG0305	Participates in initiation and elongation during chromosome replication
CGC63_RS03170	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CGC63_RS03180	COG2221	Nitrite and sulphite reductase 4Fe-4S
CGC63_RS03195	COG0534	Mate efflux family protein
CGC63_RS03205	COG0426	domain, Protein
CGC63_RS03210	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CGC63_RS03225	COG5002	protein histidine kinase activity
CGC63_RS03240	COG0701	Predicted permease
CGC63_RS03260	COG0569	domain protein
CGC63_RS03270	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CGC63_RS03280	COG1476	TRANSCRIPTIONal
CGC63_RS03290	COG4152	abc transporter atp-binding protein
CGC63_RS03295	COG1668	transmembrane transport
CGC63_RS03300	COG0363	glucosamine-6-phosphate deaminase activity
CGC63_RS03310	COG0641	radical SAM
CGC63_RS03325	COG1175	transmembrane transport
CGC63_RS03330	COG0395	ABC-type sugar transport system, permease component
CGC63_RS03345	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CGC63_RS03350	COG4868	Belongs to the UPF0371 family
CGC63_RS03355	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CGC63_RS03360	COG0322	excinuclease ABC activity
CGC63_RS03365	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CGC63_RS03370	COG1940	carbohydrate kinase activity
CGC63_RS03375	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CGC63_RS03535	COG0740	serine-type endopeptidase activity
CGC63_RS03655	COG0629	single-stranded DNA binding
CGC63_RS03675	COG3773	Cell wall hydrolase
CGC63_RS03680	COG2176	DNA-directed DNA polymerase activity
CGC63_RS03700	COG1739	Uncharacterized protein family UPF0029
CGC63_RS03705	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CGC63_RS03710	COG0802	atpase or kinase
CGC63_RS03715	COG1214	PFAM Peptidase M22, glycoprotease
CGC63_RS03720	COG0456	acetyltransferase
CGC63_RS03730	COG1234	tRNA 3'-trailer cleavage
CGC63_RS03735	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CGC63_RS03740	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CGC63_RS03820	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CGC63_RS03835	COG1596	polysaccharide export
CGC63_RS03835	COG1555	photosystem II stabilization
CGC63_RS03840	COG0745	RESPONSE REGULATOR receiver
CGC63_RS03845	COG5002	protein histidine kinase activity
CGC63_RS03865	COG0268	Binds directly to 16S ribosomal RNA
CGC63_RS03870	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
CGC63_RS03960	COG0455	bacterial-type flagellum organization
CGC63_RS03985	COG0629	single-stranded DNA binding
CGC63_RS04010	COG4626	Terminase
CGC63_RS04010	COG1802	Transcriptional regulator
CGC63_RS04150	COG0481	GTPase activity
CGC63_RS04155	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CGC63_RS04170	COG1077	Cell shape determining protein MreB Mrl
CGC63_RS04175	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CGC63_RS04180	COG1040	competence protein
CGC63_RS04195	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
CGC63_RS04220	COG1686	Belongs to the peptidase S11 family
CGC63_RS04225	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CGC63_RS04255	COG2966	Psort location CytoplasmicMembrane, score
CGC63_RS04265	COG0549	Belongs to the carbamate kinase family
CGC63_RS04270	COG1363	Peptidase, m42
CGC63_RS04275	COG0426	domain, Protein
CGC63_RS04280	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CGC63_RS04290	COG1242	4 iron, 4 sulfur cluster binding
CGC63_RS04305	COG1070	Carbohydrate kinase
CGC63_RS04310	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CGC63_RS04315	COG4496	protein, YerC YecD
CGC63_RS04405	COG1396	sequence-specific DNA binding
CGC63_RS04415	COG0242	peptide deformylase activity
CGC63_RS04425	COG3845	ABC transporter
CGC63_RS04430	COG4603	Belongs to the binding-protein-dependent transport system permease family
CGC63_RS04435	COG1079	Belongs to the binding-protein-dependent transport system permease family
CGC63_RS04465	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CGC63_RS04470	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
CGC63_RS04485	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CGC63_RS04490	COG0191	fructose-bisphosphate aldolase activity
CGC63_RS04525	COG0166	Belongs to the GPI family
CGC63_RS04535	COG2267	carboxylic ester hydrolase activity
CGC63_RS04550	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CGC63_RS04555	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CGC63_RS04565	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CGC63_RS04575	COG1442	glycosyl transferase family 8
CGC63_RS04575	COG1216	Glycosyl transferase, family 2
CGC63_RS04580	COG0438	transferase activity, transferring glycosyl groups
CGC63_RS04585	COG3475	LICD family
CGC63_RS04595	COG3409	Peptidoglycan-binding domain 1 protein
CGC63_RS04595	COG3757	hydrolase, family 25
CGC63_RS04600	COG0574	Belongs to the PEP-utilizing enzyme family
CGC63_RS04600	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CGC63_RS04615	COG0562	UDP-galactopyranose mutase
CGC63_RS04620	COG2246	polysaccharide biosynthetic process
CGC63_RS04625	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CGC63_RS04630	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CGC63_RS04640	COG0733	neurotransmitter:sodium symporter activity
CGC63_RS04645	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CGC63_RS04660	COG0745	RESPONSE REGULATOR receiver
CGC63_RS04665	COG0642	Histidine kinase
CGC63_RS04670	COG1136	(ABC) transporter
CGC63_RS04675	COG0577	efflux transmembrane transporter activity
CGC63_RS04685	COG0601	transmembrane transport
CGC63_RS04695	COG0577	efflux transmembrane transporter activity
CGC63_RS04695	COG1136	(ABC) transporter
CGC63_RS04725	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CGC63_RS04730	COG3829	transcription factor binding
CGC63_RS04740	COG2986	histidine ammonia-lyase
CGC63_RS04765	COG4656	Part of a membrane complex involved in electron transport
CGC63_RS04770	COG4658	electron transport chain
CGC63_RS04795	COG0346	lactoylglutathione lyase activity
CGC63_RS04800	COG0346	lactoylglutathione lyase activity
CGC63_RS04825	COG1122	ATPase activity
CGC63_RS04855	COG0726	polysaccharide deacetylase
CGC63_RS04860	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CGC63_RS04865	COG0436	Aminotransferase
CGC63_RS04880	COG1132	(ABC) transporter
CGC63_RS04895	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CGC63_RS04905	COG1191	sigma factor activity
CGC63_RS04915	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CGC63_RS04925	COG0778	Nitroreductase
CGC63_RS04965	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CGC63_RS04975	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CGC63_RS04980	COG1381	Involved in DNA repair and RecF pathway recombination
CGC63_RS04985	COG3525	Glycosyl hydrolase, family 20, catalytic domain
CGC63_RS04990	COG0423	glycine-tRNA ligase activity
CGC63_RS05000	COG2200	EAL domain
CGC63_RS05000	COG2199	diguanylate cyclase activity
CGC63_RS05000	COG2202	Pas domain
CGC63_RS05010	COG0205	6-phosphofructokinase activity
CGC63_RS05020	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CGC63_RS05050	COG0024	Methionine aminopeptidase
CGC63_RS05060	COG0138	bifunctional purine biosynthesis protein purh
CGC63_RS05070	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CGC63_RS05080	COG0708	Exodeoxyribonuclease III
CGC63_RS05085	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CGC63_RS05105	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CGC63_RS05115	COG1937	Protein conserved in bacteria
CGC63_RS05130	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CGC63_RS05130	COG1199	ATP-dependent helicase activity
CGC63_RS05135	COG0583	DNA-binding transcription factor activity
CGC63_RS05140	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CGC63_RS05145	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CGC63_RS05150	COG0463	Glycosyl transferase, family 2
CGC63_RS05160	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CGC63_RS05175	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CGC63_RS05180	COG1882	Formate acetyltransferase
CGC63_RS05185	COG1882	Formate acetyltransferase
CGC63_RS05195	COG4536	flavin adenine dinucleotide binding
CGC63_RS05215	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CGC63_RS05220	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CGC63_RS05220	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CGC63_RS05225	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CGC63_RS05225	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CGC63_RS05235	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CGC63_RS05240	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CGC63_RS05245	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CGC63_RS05250	COG0124	histidyl-tRNA synthetase
CGC63_RS05255	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CGC63_RS05275	COG0577	efflux transmembrane transporter activity
CGC63_RS05290	COG0366	Alpha amylase catalytic
CGC63_RS05295	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
CGC63_RS05305	COG0052	Belongs to the universal ribosomal protein uS2 family
CGC63_RS05310	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CGC63_RS05320	COG4667	esterase of the alpha-beta hydrolase superfamily
CGC63_RS05325	COG2001	Belongs to the MraZ family
CGC63_RS05340	COG0768	penicillin binding
CGC63_RS05345	COG0768	penicillin binding
CGC63_RS05355	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CGC63_RS05360	COG0772	Belongs to the SEDS family
CGC63_RS05365	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CGC63_RS05380	COG0686	Belongs to the AlaDH PNT family
CGC63_RS05385	COG1115	amino acid carrier protein
CGC63_RS05395	COG0710	3-dehydroquinate dehydratase activity
CGC63_RS05405	COG1191	sigma factor activity
CGC63_RS05415	COG3711	transcriptional antiterminator
CGC63_RS05435	COG1263	PTS System
CGC63_RS05435	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CGC63_RS05435	COG2190	(PTS) system
CGC63_RS05440	COG1263	PTS System
CGC63_RS05440	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CGC63_RS05460	COG0745	RESPONSE REGULATOR receiver
CGC63_RS05465	COG2205	protein histidine kinase activity
CGC63_RS05485	COG1414	Transcriptional regulator
CGC63_RS05490	COG0800	Aldolase
CGC63_RS05500	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CGC63_RS05520	COG1937	Protein conserved in bacteria
CGC63_RS05530	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CGC63_RS05535	COG0488	(ABC) transporter
CGC63_RS05540	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CGC63_RS05545	COG1045	serine acetyltransferase
CGC63_RS05550	COG0215	cysteine-tRNA ligase activity
CGC63_RS05560	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CGC63_RS05570	COG5492	domain, Protein
CGC63_RS05585	COG1854	S-ribosylhomocysteine lyase activity
CGC63_RS05605	COG0577	efflux transmembrane transporter activity
CGC63_RS05605	COG1136	(ABC) transporter
CGC63_RS05615	COG0577	efflux transmembrane transporter activity
CGC63_RS05620	COG0564	pseudouridine synthase activity
CGC63_RS05625	COG1177	transmembrane transport
CGC63_RS05630	COG1176	ABC-type spermidine putrescine transport system, permease component I
CGC63_RS05635	COG3842	ATPase activity
CGC63_RS05655	COG0469	pyruvate kinase activity
CGC63_RS05685	COG0613	PHP domain protein
CGC63_RS05700	COG0187	DNA topoisomerase II activity
CGC63_RS05705	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CGC63_RS05720	COG0195	Participates in both transcription termination and antitermination
CGC63_RS05725	COG2740	Nucleic-acid-binding protein implicated in transcription termination
CGC63_RS05735	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CGC63_RS05740	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CGC63_RS05745	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CGC63_RS05750	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CGC63_RS05755	COG0196	riboflavin kinase activity
CGC63_RS05760	COG1283	sodium-dependent phosphate transmembrane transporter activity
CGC63_RS05765	COG0791	NLP P60 protein
CGC63_RS05770	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CGC63_RS05775	COG1185	polyribonucleotide nucleotidyltransferase activity
CGC63_RS05780	COG0602	queuosine metabolic process
CGC63_RS05790	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CGC63_RS05805	COG1523	belongs to the glycosyl hydrolase 13 family
CGC63_RS05820	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CGC63_RS05825	COG1904	glucuronate isomerase
CGC63_RS05830	COG2233	PERMEase
CGC63_RS05875	COG0346	lactoylglutathione lyase activity
CGC63_RS05895	COG0655	NAD(P)H dehydrogenase (quinone) activity
CGC63_RS05930	COG1192	Involved in chromosome partitioning
CGC63_RS05935	COG1475	DNA binding
CGC63_RS05965	COG0732	type I restriction modification DNA specificity domain
CGC63_RS05980	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CGC63_RS05995	COG0582	viral genome integration into host DNA
CGC63_RS06090	COG3853	Toxic anion resistance protein (TelA)
CGC63_RS06100	COG0629	single-stranded DNA binding
CGC63_RS06130	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CGC63_RS06135	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CGC63_RS06140	COG3118	belongs to the thioredoxin family
CGC63_RS06145	COG0492	ferredoxin-NADP+ reductase activity
CGC63_RS06150	COG0356	it plays a direct role in the translocation of protons across the membrane
CGC63_RS06155	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CGC63_RS06160	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CGC63_RS06165	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CGC63_RS06170	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CGC63_RS06175	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CGC63_RS06180	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CGC63_RS06185	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CGC63_RS06190	COG3328	transposase activity
CGC63_RS06200	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CGC63_RS06205	COG0583	DNA-binding transcription factor activity
CGC63_RS06210	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CGC63_RS06220	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CGC63_RS06225	COG2186	Transcriptional regulator
CGC63_RS06240	COG1028	Short-chain dehydrogenase reductase Sdr
CGC63_RS06270	COG1131	(ABC) transporter
CGC63_RS06285	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CGC63_RS06295	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CGC63_RS06315	COG2385	sporulation resulting in formation of a cellular spore
CGC63_RS06325	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CGC63_RS06335	COG0588	phosphoglycerate mutase activity
CGC63_RS06340	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CGC63_RS06345	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CGC63_RS06360	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CGC63_RS06370	COG0495	leucyl-tRNA aminoacylation
CGC63_RS06385	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CGC63_RS06405	COG0456	acetyltransferase
CGC63_RS06415	COG0519	Catalyzes the synthesis of GMP from XMP
CGC63_RS06430	COG1293	RNA-binding protein homologous to eukaryotic snRNP
CGC63_RS06435	COG1561	YicC-like family, N-terminal region
CGC63_RS06445	COG0194	GDP metabolic process
CGC63_RS06450	COG1758	RNA polymerase activity
CGC63_RS06455	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CGC63_RS06460	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CGC63_RS06465	COG1058	Belongs to the CinA family
CGC63_RS06465	COG1546	Belongs to the CinA family
CGC63_RS06480	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CGC63_RS06485	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CGC63_RS06490	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CGC63_RS06500	COG1686	Belongs to the peptidase S11 family
CGC63_RS06505	COG1408	metallophosphoesterase
CGC63_RS06510	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CGC63_RS06515	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CGC63_RS06520	COG1686	Belongs to the peptidase S11 family
CGC63_RS06535	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CGC63_RS06550	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CGC63_RS06565	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CGC63_RS06575	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CGC63_RS06580	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
CGC63_RS06595	COG2081	HI0933 family
CGC63_RS06600	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CGC63_RS06605	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CGC63_RS06610	COG0539	negative regulation of cytoplasmic translation
CGC63_RS06610	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CGC63_RS06630	COG4658	electron transport chain
CGC63_RS06635	COG4659	FMN binding
CGC63_RS06640	COG4660	Part of a membrane complex involved in electron transport
CGC63_RS06645	COG4657	Part of a membrane complex involved in electron transport
CGC63_RS06650	COG1245	4Fe-4S binding domain
CGC63_RS06650	COG2878	Part of a membrane complex involved in electron transport
CGC63_RS06665	COG0632	four-way junction helicase activity
CGC63_RS06670	COG2255	four-way junction helicase activity
CGC63_RS06680	COG0826	peptidase U32
CGC63_RS06690	COG0768	penicillin binding
CGC63_RS06695	COG1051	belongs to the nudix hydrolase family
CGC63_RS06715	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CGC63_RS06725	COG1461	Dihydroxyacetone kinase
CGC63_RS06730	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CGC63_RS06740	COG1803	Methylglyoxal synthase
CGC63_RS06745	COG0742	ribosomal rna small subunit methyltransferase
CGC63_RS06750	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CGC63_RS06765	COG2195	Cleaves the N-terminal amino acid of tripeptides
CGC63_RS06770	COG0739	heme binding
CGC63_RS06775	COG2357	RelA SpoT domain protein
CGC63_RS06780	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
CGC63_RS06780	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CGC63_RS06785	COG1187	pseudouridine synthase activity
CGC63_RS06790	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CGC63_RS06800	COG4221	oxidoreductase activity
CGC63_RS06820	COG3331	DNA recombination
CGC63_RS06830	COG0281	malic enzyme
CGC63_RS06840	COG0584	glycerophosphoryl diester phosphodiesterase
CGC63_RS06845	COG3341	Caulimovirus viroplasmin
CGC63_RS06845	COG0328	RNA-DNA hybrid ribonuclease activity
CGC63_RS06850	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CGC63_RS06855	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CGC63_RS06860	COG0512	Glutamine amidotransferase of anthranilate synthase
CGC63_RS06865	COG0285	dihydrofolate synthase activity
CGC63_RS06875	COG1418	mRNA catabolic process
CGC63_RS06880	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CGC63_RS06885	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CGC63_RS06885	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CGC63_RS06910	COG0745	RESPONSE REGULATOR receiver
CGC63_RS06915	COG5002	protein histidine kinase activity
CGC63_RS06945	COG2188	Transcriptional regulator
CGC63_RS06965	COG0534	Mate efflux family protein
CGC63_RS07035	COG1598	PFAM Uncharacterised protein family UPF0150
CGC63_RS07045	COG1686	Belongs to the peptidase S11 family
CGC63_RS07055	COG0037	tRNA processing
CGC63_RS07060	COG1691	(AIR) carboxylase
CGC63_RS07065	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CGC63_RS07075	COG1120	ATPase activity
CGC63_RS07080	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CGC63_RS07090	COG0778	Nitroreductase
CGC63_RS07125	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CGC63_RS07135	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CGC63_RS07135	COG0723	plastoquinol--plastocyanin reductase activity
CGC63_RS07145	COG1490	D-aminoacyl-tRNA deacylase activity
CGC63_RS07150	COG0628	permease
CGC63_RS07155	COG0037	tRNA processing
CGC63_RS07165	COG0564	pseudouridine synthase activity
CGC63_RS07175	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CGC63_RS07190	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CGC63_RS07200	COG2155	Conserved Protein
CGC63_RS07215	COG1803	Methylglyoxal synthase
CGC63_RS07220	COG0772	Belongs to the SEDS family
CGC63_RS07225	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CGC63_RS07230	COG2894	cell division
CGC63_RS07235	COG0768	penicillin binding
CGC63_RS07235	COG0768	penicillin binding
CGC63_RS07250	COG1077	Cell shape determining protein MreB Mrl
CGC63_RS07255	COG2003	Belongs to the UPF0758 family
CGC63_RS07260	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
CGC63_RS07265	COG2081	HI0933 family
CGC63_RS07270	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
CGC63_RS07275	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CGC63_RS07285	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CGC63_RS07295	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CGC63_RS07300	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CGC63_RS07305	COG4224	UPF0291 protein
CGC63_RS07310	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CGC63_RS07320	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CGC63_RS07325	COG1702	phosphate starvation-inducible protein PhoH
CGC63_RS07345	COG0419	ATPase involved in DNA repair
CGC63_RS07350	COG0420	3'-5' exonuclease activity
CGC63_RS07365	COG3973	AAA domain
CGC63_RS07405	COG1733	regulation of RNA biosynthetic process
CGC63_RS07430	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CGC63_RS07435	COG0275	rRNA processing
CGC63_RS07445	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CGC63_RS07465	COG0493	'glutamate synthase
CGC63_RS07465	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CGC63_RS07480	COG1674	ftsk spoiiie
CGC63_RS07485	COG1968	undecaprenyl-diphosphatase activity
CGC63_RS07490	COG0740	serine-type endopeptidase activity
CGC63_RS07495	COG0217	transcriptional regulatory protein
CGC63_RS07500	COG4535	Mg2 and Co2 transporter CorC
CGC63_RS07505	COG2337	Toxic component of a toxin-antitoxin (TA) module
CGC63_RS07510	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CGC63_RS07515	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CGC63_RS07515	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CGC63_RS07520	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
CGC63_RS07525	COG0488	(ABC) transporter
CGC63_RS07530	COG0538	isocitrate dehydrogenase activity
CGC63_RS07535	COG1404	Belongs to the peptidase S8 family
CGC63_RS07760	COG0483	inositol monophosphate 1-phosphatase activity
CGC63_RS07775	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CGC63_RS07780	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CGC63_RS07785	COG0113	porphobilinogen synthase activity
CGC63_RS07795	COG0181	hydroxymethylbilane synthase activity
CGC63_RS07805	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CGC63_RS07810	COG0310	cobalt ion transport
CGC63_RS07830	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CGC63_RS07835	COG1686	Belongs to the peptidase S11 family
CGC63_RS07855	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CGC63_RS07870	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
CGC63_RS07875	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
CGC63_RS07885	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CGC63_RS07920	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
CGC63_RS07930	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CGC63_RS07935	COG0632	four-way junction helicase activity
CGC63_RS07945	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CGC63_RS07950	COG3404	Formiminotransferase-cyclodeaminase
CGC63_RS07955	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CGC63_RS07995	COG1151	hydroxylamine reductase activity
CGC63_RS08005	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CGC63_RS08020	COG0656	L-ascorbic acid biosynthetic process
CGC63_RS08025	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CGC63_RS08030	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CGC63_RS08045	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CGC63_RS08055	COG0792	nuclease activity
CGC63_RS08060	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CGC63_RS08075	COG0335	large ribosomal subunit rRNA binding
CGC63_RS08080	COG0336	Belongs to the RNA methyltransferase TrmD family
CGC63_RS08085	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CGC63_RS08090	COG1837	Belongs to the UPF0109 family
CGC63_RS08100	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CGC63_RS08115	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
CGC63_RS08120	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
CGC63_RS08125	COG0351	phosphomethylpyrimidine kinase
CGC63_RS08125	COG0352	thiamine-phosphate diphosphorylase activity
CGC63_RS08135	COG1393	Belongs to the ArsC family
CGC63_RS08140	COG2703	oxygen carrier activity
CGC63_RS08150	COG1268	BioY protein
CGC63_RS08160	COG2972	Histidine kinase
CGC63_RS08165	COG4753	response regulator
CGC63_RS08165	COG2207	Transcriptional regulator
CGC63_RS08215	COG0438	transferase activity, transferring glycosyl groups
CGC63_RS08250	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CGC63_RS08255	COG0552	protein localization to endoplasmic reticulum
CGC63_RS08260	COG1196	nuclear chromosome segregation
CGC63_RS08265	COG0571	ribonuclease III activity
CGC63_RS08270	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CGC63_RS08285	COG3620	sequence-specific DNA binding
CGC63_RS08290	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
CGC63_RS08300	COG0383	alpha-mannosidase activity
CGC63_RS08305	COG1609	Transcriptional regulator
CGC63_RS08310	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CGC63_RS08330	COG2848	UPF0210 protein
CGC63_RS08340	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CGC63_RS08345	COG0237	dephospho-CoA kinase activity
CGC63_RS08365	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CGC63_RS08385	COG1725	Transcriptional regulator
CGC63_RS08410	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CGC63_RS08415	COG0527	aspartate kinase activity
CGC63_RS08420	COG0697	spore germination
CGC63_RS08430	COG0540	Belongs to the ATCase OTCase family
CGC63_RS08440	COG0077	Prephenate dehydratase
CGC63_RS08440	COG1605	Chorismate mutase
CGC63_RS08460	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CGC63_RS08470	COG0799	negative regulation of ribosome biogenesis
CGC63_RS08475	COG1713	HD superfamily hydrolase involved in NAD metabolism
CGC63_RS08480	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CGC63_RS08485	COG1534	Rna-binding protein
CGC63_RS08490	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CGC63_RS08495	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CGC63_RS08515	COG1051	belongs to the nudix hydrolase family
CGC63_RS08520	COG1530	ribonuclease E activity
CGC63_RS08565	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CGC63_RS08570	COG0358	DNA primase activity
CGC63_RS08575	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CGC63_RS08580	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CGC63_RS08595	COG0402	S-adenosylhomocysteine deaminase activity
CGC63_RS08615	COG0750	zinc metalloprotease
CGC63_RS08620	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CGC63_RS08625	COG4589	Belongs to the CDS family
CGC63_RS08630	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CGC63_RS08635	COG0233	cytoplasmic translational termination
CGC63_RS08640	COG0528	UMP kinase activity
CGC63_RS08645	COG0733	neurotransmitter:sodium symporter activity
CGC63_RS08660	COG1131	(ABC) transporter
CGC63_RS08665	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CGC63_RS08670	COG3344	reverse transcriptase
CGC63_RS08695	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
CGC63_RS08700	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CGC63_RS08715	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CGC63_RS08720	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CGC63_RS08720	COG0551	DNA topoisomerase type I activity
CGC63_RS08730	COG0165	Argininosuccinate lyase
CGC63_RS08735	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CGC63_RS08740	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CGC63_RS08750	COG1695	Transcriptional regulator
CGC63_RS08755	COG1116	anion transmembrane transporter activity
CGC63_RS08760	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CGC63_RS08770	COG1105	Belongs to the carbohydrate kinase PfkB family
CGC63_RS08780	COG0719	Fe-S assembly protein
CGC63_RS08785	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CGC63_RS08810	COG3279	Response regulator of the LytR AlgR family
CGC63_RS08835	COG1177	transmembrane transport
CGC63_RS08840	COG1176	ABC-type spermidine putrescine transport system, permease component I
CGC63_RS08845	COG3842	ATPase activity
CGC63_RS08870	COG1827	regulation of RNA biosynthetic process
CGC63_RS08875	COG0157	Belongs to the NadC ModD family
CGC63_RS08885	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CGC63_RS08890	COG1373	ATPase (AAA superfamily
CGC63_RS08900	COG0789	Transcriptional regulator
CGC63_RS08920	COG3842	ATPase activity
CGC63_RS08925	COG4120	Belongs to the binding-protein-dependent transport system permease family
CGC63_RS08940	COG0534	Mate efflux family protein
CGC63_RS08950	COG3655	Transcriptional regulator
CGC63_RS08980	COG2186	Transcriptional regulator
CGC63_RS08990	COG0375	protein maturation
CGC63_RS08995	COG0493	'glutamate synthase
CGC63_RS09015	COG0668	transmembrane transport
CGC63_RS09020	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CGC63_RS09040	COG3842	ATPase activity
CGC63_RS09055	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CGC63_RS09060	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CGC63_RS09065	COG0028	Belongs to the TPP enzyme family
CGC63_RS09070	COG0129	dihydroxy-acid dehydratase activity
CGC63_RS09080	COG1760	l-serine dehydratase
CGC63_RS09085	COG1760	l-serine dehydratase
CGC63_RS09095	COG0343	queuine tRNA-ribosyltransferase activity
CGC63_RS09115	COG5002	protein histidine kinase activity
CGC63_RS09120	COG0745	RESPONSE REGULATOR receiver
CGC63_RS09245	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CGC63_RS09250	COG0587	DNA-directed DNA polymerase activity
CGC63_RS09260	COG0587	DNA-directed DNA polymerase activity
CGC63_RS09270	COG0587	DNA-directed DNA polymerase activity
CGC63_RS09285	COG0358	DNA primase activity
CGC63_RS09300	COG2887	Belongs to the helicase family. UvrD subfamily
CGC63_RS09315	COG0563	adenylate kinase activity
CGC63_RS09345	COG2304	oxidoreductase activity
CGC63_RS09350	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CGC63_RS09375	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CGC63_RS09390	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
CGC63_RS09680	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CGC63_RS09825	COG2205	protein histidine kinase activity
CGC63_RS09830	COG0745	RESPONSE REGULATOR receiver
CGC63_RS09880	COG0791	NLP P60 protein
CGC63_RS10020	COG1484	DNA-dependent DNA replication
CGC63_RS10065	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CGC63_RS10065	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CGC63_RS10105	COG1475	DNA binding
CGC63_RS10155	COG0740	serine-type endopeptidase activity
CGC63_RS10425	COG4166	transmembrane transport
CGC63_RS10430	COG4608	Belongs to the ABC transporter superfamily
CGC63_RS10435	COG0444	Belongs to the ABC transporter superfamily
CGC63_RS10440	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CGC63_RS10445	COG0601	transmembrane transport
CGC63_RS10455	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CGC63_RS10460	COG0557	exoribonuclease II activity
CGC63_RS10465	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CGC63_RS10470	COG0148	phosphopyruvate hydratase activity
CGC63_RS10475	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CGC63_RS10480	COG1126	abc transporter atp-binding protein
CGC63_RS10490	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CGC63_RS10505	COG0149	triose-phosphate isomerase activity
CGC63_RS10520	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CGC63_RS10530	COG0482	sulfurtransferase activity
CGC63_RS10535	COG0822	iron-sulfur transferase activity
CGC63_RS10545	COG1959	2 iron, 2 sulfur cluster binding
CGC63_RS10550	COG2244	polysaccharide biosynthetic process
CGC63_RS10555	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CGC63_RS10560	COG4974	Belongs to the 'phage' integrase family
CGC63_RS10570	COG1418	mRNA catabolic process
CGC63_RS10575	COG2137	regulation of response to DNA damage stimulus
CGC63_RS10580	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CGC63_RS10595	COG0297	glycogen (starch) synthase activity
CGC63_RS10600	COG0745	RESPONSE REGULATOR receiver
CGC63_RS10605	COG0750	zinc metalloprotease
CGC63_RS10610	COG0497	DNA recombination
CGC63_RS10615	COG1438	arginine binding
CGC63_RS10620	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CGC63_RS10625	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
CGC63_RS10630	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CGC63_RS10640	COG1722	exodeoxyribonuclease VII activity
CGC63_RS10645	COG1570	exodeoxyribonuclease VII activity
CGC63_RS10650	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CGC63_RS10655	COG1302	Protein conserved in bacteria
CGC63_RS10660	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CGC63_RS10700	COG3854	ATPases associated with a variety of cellular activities
CGC63_RS10725	COG0210	DNA helicase
CGC63_RS10730	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CGC63_RS10735	COG2070	2-Nitropropane dioxygenase
CGC63_RS10745	COG0439	Biotin carboxylase
CGC63_RS10750	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CGC63_RS10760	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CGC63_RS10770	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CGC63_RS10775	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CGC63_RS10780	COG0772	Belongs to the SEDS family
CGC63_RS10785	COG0584	glycerophosphoryl diester phosphodiesterase
CGC63_RS10790	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CGC63_RS10800	COG3546	catalase activity
CGC63_RS10815	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CGC63_RS10820	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CGC63_RS10825	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CGC63_RS10835	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CGC63_RS10840	COG0572	uridine kinase
CGC63_RS10845	COG0768	penicillin binding
CGC63_RS10855	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CGC63_RS10865	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CGC63_RS10870	COG1070	Carbohydrate kinase
CGC63_RS10875	COG1830	Aldolase
CGC63_RS10880	COG1063	alcohol dehydrogenase
CGC63_RS10895	COG0012	GTP binding
CGC63_RS10900	COG0534	Mate efflux family protein
CGC63_RS10910	COG1564	THIamine pyrophosphokinase
CGC63_RS10915	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CGC63_RS10935	COG0631	protein serine/threonine phosphatase activity
CGC63_RS10940	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CGC63_RS10945	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CGC63_RS10945	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CGC63_RS10960	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CGC63_RS10965	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CGC63_RS10970	COG0367	asparagine synthase
CGC63_RS10975	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CGC63_RS11010	COG0010	Belongs to the arginase family
CGC63_RS11015	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CGC63_RS11020	COG1982	Orn Lys Arg decarboxylase major
CGC63_RS11040	COG2816	NAD+ diphosphatase activity
CGC63_RS11050	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CGC63_RS11055	COG1012	belongs to the aldehyde dehydrogenase family
CGC63_RS11065	COG0561	phosphatase activity
CGC63_RS11070	COG0546	phosphoglycolate phosphatase activity
CGC63_RS11090	COG1501	Belongs to the glycosyl hydrolase 31 family
CGC63_RS11095	COG0395	ABC-type sugar transport system, permease component
CGC63_RS11100	COG1175	transmembrane transport
CGC63_RS11110	COG1609	Transcriptional regulator
CGC63_RS11145	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CGC63_RS11150	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CGC63_RS11165	COG0791	NLP P60 protein
CGC63_RS11170	COG1115	amino acid carrier protein
CGC63_RS11180	COG0205	6-phosphofructokinase activity
CGC63_RS11190	COG0488	(ABC) transporter
CGC63_RS11215	COG0460	homoserine dehydrogenase
CGC63_RS11285	COG3052	prosthetic group binding
CGC63_RS11290	COG3404	Formiminotransferase-cyclodeaminase
CGC63_RS11320	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
CGC63_RS11320	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
CGC63_RS11325	COG4399	Belongs to the UPF0754 family
CGC63_RS11335	COG0484	heat shock protein binding
CGC63_RS11345	COG2357	RelA SpoT domain protein
CGC63_RS11380	COG1803	Methylglyoxal synthase
CGC63_RS11385	COG1597	lipid kinase activity
CGC63_RS11390	COG0584	glycerophosphoryl diester phosphodiesterase
CGC63_RS11400	COG1216	Glycosyl transferase, family 2
CGC63_RS11425	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CGC63_RS11430	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
CGC63_RS11445	COG1959	2 iron, 2 sulfur cluster binding
CGC63_RS11450	COG0488	(ABC) transporter
CGC63_RS11460	COG1312	Catalyzes the dehydration of D-mannonate
CGC63_RS11465	COG0246	Mannitol dehydrogenase
CGC63_RS11470	COG0534	Mate efflux family protein
CGC63_RS11480	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CGC63_RS11485	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CGC63_RS11520	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
CGC63_RS11545	COG2946	Replication initiation factor
CGC63_RS11575	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
CGC63_RS11580	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CGC63_RS11585	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CGC63_RS11590	COG1187	pseudouridine synthase activity
CGC63_RS11610	COG4509	Sortase family
CGC63_RS11645	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
CGC63_RS11650	COG0372	Belongs to the citrate synthase family
CGC63_RS11660	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CGC63_RS11675	COG0714	Associated with various cellular activities
CGC63_RS11715	COG0517	IMP dehydrogenase activity
CGC63_RS11715	COG0516	GMP reductase activity
CGC63_RS11725	COG0459	protein refolding
CGC63_RS11730	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CGC63_RS11740	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CGC63_RS11745	COG0758	DNA mediated transformation
CGC63_RS11750	COG0606	chelatase, subunit chli
CGC63_RS11760	COG0826	peptidase U32
CGC63_RS11765	COG4122	O-methyltransferase activity
CGC63_RS11780	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CGC63_RS11795	COG4472	Bacterial protein of unknown function (DUF965)
CGC63_RS11800	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CGC63_RS11815	COG1104	cysteine desulfurase activity
CGC63_RS11820	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CGC63_RS11830	COG0484	heat shock protein binding
CGC63_RS11835	COG0443	Heat shock 70 kDa protein
CGC63_RS11840	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CGC63_RS11845	COG1420	regulation of RNA biosynthetic process
CGC63_RS11955	COG4989	oxidoreductase activity
CGC63_RS11965	COG0205	6-phosphofructokinase activity
CGC63_RS11970	COG2357	RelA SpoT domain protein
CGC63_RS11975	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CGC63_RS11980	COG0251	oxidation-reduction process
CGC63_RS11985	COG2964	Protein conserved in bacteria
CGC63_RS11995	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CGC63_RS12000	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CGC63_RS12010	COG0542	response to heat
CGC63_RS12020	COG0151	Belongs to the GarS family
CGC63_RS12025	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CGC63_RS12030	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CGC63_RS12035	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CGC63_RS12105	COG0167	dihydroorotate dehydrogenase activity
CGC63_RS12110	COG0543	2 iron, 2 sulfur cluster binding
CGC63_RS12120	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CGC63_RS12125	COG1278	Cold shock
CGC63_RS12130	COG0778	Nitroreductase
CGC63_RS12150	COG0101	tRNA pseudouridine synthase activity
CGC63_RS12155	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CGC63_RS12160	COG1122	ATPase activity
CGC63_RS12165	COG1122	ATPase activity
CGC63_RS12170	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CGC63_RS12175	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CGC63_RS12180	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CGC63_RS12190	COG0740	serine-type endopeptidase activity
CGC63_RS12195	COG0544	peptidyl-prolyl cis-trans isomerase activity
CGC63_RS12210	COG2954	triphosphatase activity
CGC63_RS12215	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CGC63_RS12225	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CGC63_RS12270	COG1191	sigma factor activity
CGC63_RS12280	COG1917	Cupin 2, conserved barrel domain protein
CGC63_RS12280	COG2207	Transcriptional regulator
CGC63_RS12285	COG5426	von Willebrand factor, type A
CGC63_RS12290	COG1757	Na H antiporter
CGC63_RS12300	COG1316	TRANSCRIPTIONal
CGC63_RS12310	COG1132	(ABC) transporter
CGC63_RS12315	COG4988	ABC transporter
CGC63_RS12320	COG2832	Protein of unknown function (DUF454)
CGC63_RS12325	COG0577	efflux transmembrane transporter activity
CGC63_RS12330	COG1136	(ABC) transporter
CGC63_RS12335	COG2205	protein histidine kinase activity
CGC63_RS12345	COG0366	Alpha amylase catalytic
CGC63_RS12360	COG0577	efflux transmembrane transporter activity
CGC63_RS12360	COG1136	(ABC) transporter
CGC63_RS12370	COG0745	RESPONSE REGULATOR receiver
CGC63_RS12375	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CGC63_RS12380	COG2890	protein-(glutamine-N5) methyltransferase activity
CGC63_RS12385	COG3872	metal-dependent enzyme
CGC63_RS12390	COG0254	rRNA binding
CGC63_RS12415	COG0653	protein targeting
CGC63_RS12420	COG1253	flavin adenine dinucleotide binding
CGC63_RS12440	COG0165	Argininosuccinate lyase
CGC63_RS12465	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CGC63_RS12470	COG3104	oligopeptide transport
CGC63_RS12475	COG2205	protein histidine kinase activity
CGC63_RS12500	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CGC63_RS12505	COG3853	Toxic anion resistance protein (TelA)
CGC63_RS12515	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CGC63_RS12520	COG3022	response to hydroperoxide
CGC63_RS12525	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CGC63_RS12530	COG3870	Protein conserved in bacteria
CGC63_RS12550	COG0778	Nitroreductase
CGC63_RS12560	COG1131	(ABC) transporter
CGC63_RS12575	COG3250	beta-galactosidase activity
CGC63_RS12580	COG2211	Major facilitator Superfamily
CGC63_RS12585	COG0110	maltose O-acetyltransferase activity
CGC63_RS12595	COG0739	heme binding
CGC63_RS12595	COG1196	nuclear chromosome segregation
CGC63_RS12595	COG0741	lytic transglycosylase activity
CGC63_RS12600	COG2177	Part of the ABC transporter FtsEX involved in
CGC63_RS12605	COG2884	Cell division ATP-binding protein ftsE
CGC63_RS12610	COG3835	regulator
CGC63_RS12645	COG0203	ribosomal protein L17
CGC63_RS12650	COG0202	RNA polymerase activity
CGC63_RS12655	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CGC63_RS12660	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CGC63_RS12665	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CGC63_RS12670	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CGC63_RS12675	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CGC63_RS12690	COG0563	adenylate kinase activity
CGC63_RS12700	COG0200	Binds to the 23S rRNA
CGC63_RS12705	COG1841	ribosomal large subunit assembly
CGC63_RS12710	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CGC63_RS12720	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CGC63_RS12725	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CGC63_RS12730	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CGC63_RS12750	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CGC63_RS12755	COG0255	Belongs to the universal ribosomal protein uL29 family
CGC63_RS12760	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CGC63_RS12770	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CGC63_RS12780	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CGC63_RS12785	COG0089	rRNA binding
CGC63_RS12795	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CGC63_RS12800	COG0051	transcription antitermination factor activity, RNA binding
CGC63_RS12810	COG1362	aminopeptidase activity
CGC63_RS12815	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CGC63_RS12820	COG1481	regulation of sporulation
CGC63_RS12835	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CGC63_RS12870	COG2172	sigma factor antagonist activity
CGC63_RS12875	COG1366	Belongs to the anti-sigma-factor antagonist family
CGC63_RS12890	COG0285	dihydrofolate synthase activity
CGC63_RS12900	COG0525	valine-tRNA ligase activity
CGC63_RS12915	COG1131	(ABC) transporter
CGC63_RS12925	COG1983	PspC domain protein
CGC63_RS12955	COG1074	ATP-dependent DNA helicase activity
CGC63_RS12960	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
CGC63_RS12965	COG0561	phosphatase activity
CGC63_RS12985	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CGC63_RS12990	COG2226	methyltransferase
CGC63_RS13010	COG1136	(ABC) transporter
CGC63_RS13020	COG0745	RESPONSE REGULATOR receiver
CGC63_RS13025	COG2239	Acts as a magnesium transporter
CGC63_RS13035	COG0542	response to heat
CGC63_RS13055	COG4804	nuclease activity
CGC63_RS13165	COG0492	ferredoxin-NADP+ reductase activity
CGC63_RS13170	COG3250	beta-galactosidase activity
CGC63_RS13215	COG0785	Cytochrome C biogenesis protein
CGC63_RS13220	COG0352	thiamine-phosphate diphosphorylase activity
CGC63_RS13230	COG2022	thiamine diphosphate biosynthetic process
CGC63_RS13235	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CGC63_RS13250	COG4978	Transcriptional regulator
CGC63_RS13250	COG0789	Transcriptional regulator
CGC63_RS13260	COG1131	(ABC) transporter
CGC63_RS13275	COG2205	protein histidine kinase activity
CGC63_RS13290	COG0745	RESPONSE REGULATOR receiver
CGC63_RS13295	COG2205	protein histidine kinase activity
CGC63_RS13300	COG2205	protein histidine kinase activity
CGC63_RS13305	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
CGC63_RS13310	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
CGC63_RS13330	COG3304	Inner membrane component domain
CGC63_RS13335	COG1028	Short-chain dehydrogenase reductase Sdr
CGC63_RS13340	COG0583	DNA-binding transcription factor activity
CGC63_RS13345	COG0076	glutamate decarboxylase activity
CGC63_RS13385	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CGC63_RS13390	COG1518	maintenance of DNA repeat elements
CGC63_RS13400	COG1203	CRISPR-associated helicase, Cas3
CGC63_RS13470	COG4974	Belongs to the 'phage' integrase family
CGC63_RS13480	COG1396	sequence-specific DNA binding
CGC63_RS13485	COG0519	Catalyzes the synthesis of GMP from XMP
CGC63_RS13495	COG0006	proline dipeptidase activity
CGC63_RS13500	COG2183	response to ionizing radiation
CGC63_RS13520	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
CGC63_RS13525	COG4492	Belongs to the UPF0735 family
CGC63_RS13530	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CGC63_RS13540	COG0653	protein targeting
CGC63_RS13550	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CGC63_RS13560	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CGC63_RS13565	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CGC63_RS13580	COG1217	gtp-binding protein TYPA
CGC63_RS13605	COG1175	transmembrane transport
CGC63_RS13630	COG2972	Histidine kinase
CGC63_RS13635	COG4753	response regulator
CGC63_RS13635	COG2207	Transcriptional regulator
CGC63_RS13640	COG4211	Belongs to the binding-protein-dependent transport system permease family
CGC63_RS13645	COG1129	ABC transporter
CGC63_RS13650	COG1879	ABC-type sugar transport system periplasmic component
CGC63_RS13670	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CGC63_RS13680	COG0537	adenosine 5'-monophosphoramidase activity
CGC63_RS13685	COG3852	Histidine kinase
CGC63_RS13690	COG0705	Rhomboid family
CGC63_RS13690	COG0457	Tetratricopeptide repeat
CGC63_RS13755	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CGC63_RS13775	COG0733	neurotransmitter:sodium symporter activity
CGC63_RS13795	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CGC63_RS13810	COG1269	ATP hydrolysis coupled proton transport
CGC63_RS13830	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
CGC63_RS13840	COG1394	ATPase activity, coupled to movement of substances
CGC63_RS13850	COG5002	protein histidine kinase activity
CGC63_RS13855	COG0745	RESPONSE REGULATOR receiver
CGC63_RS13865	COG0436	Aminotransferase
CGC63_RS13870	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CGC63_RS13875	COG0504	CTP synthase activity
CGC63_RS13890	COG0367	asparagine synthase
CGC63_RS13900	COG0067	glutamate synthase
CGC63_RS13905	COG0069	glutamate synthase activity
CGC63_RS13925	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CGC63_RS13930	COG0581	inorganic phosphate transmembrane transporter activity
CGC63_RS13935	COG0573	inorganic phosphate transmembrane transporter activity
CGC63_RS13945	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CGC63_RS13975	COG1744	ABC transporter substrate-binding protein PnrA-like
CGC63_RS13990	COG1079	Belongs to the binding-protein-dependent transport system permease family
CGC63_RS13995	COG4603	Belongs to the binding-protein-dependent transport system permease family
CGC63_RS14000	COG3845	ABC transporter
CGC63_RS14005	COG0295	cytidine deaminase activity
CGC63_RS14010	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CGC63_RS14080	COG3958	Transketolase
CGC63_RS14085	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CGC63_RS14100	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CGC63_RS14105	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CGC63_RS14110	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CGC63_RS14120	COG0586	Pfam SNARE associated Golgi protein
CGC63_RS14130	COG0590	tRNA wobble adenosine to inosine editing
CGC63_RS14155	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CGC63_RS14155	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
CGC63_RS14160	COG1132	(ABC) transporter
CGC63_RS14175	COG0789	Transcriptional regulator
CGC63_RS14175	COG4978	Transcriptional regulator
CGC63_RS14180	COG2088	sporulation resulting in formation of a cellular spore
CGC63_RS14185	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CGC63_RS14190	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CGC63_RS14210	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CGC63_RS14220	COG4717	serine-type aminopeptidase activity
CGC63_RS14230	COG0017	Asparaginyl-tRNA synthetase
CGC63_RS14260	COG1595	DNA-templated transcription, initiation
CGC63_RS14295	COG0640	Transcriptional regulator
CGC63_RS14300	COG1283	sodium-dependent phosphate transmembrane transporter activity
CGC63_RS14310	COG1309	transcriptional regulator
CGC63_RS14320	COG2252	PERMEase
CGC63_RS14325	COG1971	Probably functions as a manganese efflux pump
CGC63_RS14345	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CGC63_RS14350	COG0601	transmembrane transport
CGC63_RS14355	COG2226	methyltransferase
CGC63_RS14360	COG2226	methyltransferase
CGC63_RS14360	COG1073	alpha beta
CGC63_RS14370	COG3681	Belongs to the UPF0597 family
CGC63_RS14380	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CGC63_RS14390	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CGC63_RS14395	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CGC63_RS14400	COG0049	tRNA binding
CGC63_RS14405	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CGC63_RS14415	COG0395	ABC-type sugar transport system, permease component
CGC63_RS14420	COG1175	transmembrane transport
CGC63_RS14430	COG1940	carbohydrate kinase activity
CGC63_RS14435	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CGC63_RS14440	COG0085	RNA polymerase activity
CGC63_RS14460	COG0833	amino acid
CGC63_RS14470	COG0222	ribosome binding
CGC63_RS14480	COG2715	membrane protein required for spore maturation
CGC63_RS14485	COG2843	Capsule synthesis protein
CGC63_RS14490	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CGC63_RS14495	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CGC63_RS14500	COG1774	PSP1 C-terminal conserved region
CGC63_RS14510	COG0194	GDP metabolic process
CGC63_RS14515	COG1982	Orn Lys Arg decarboxylase major
CGC63_RS14520	COG0745	RESPONSE REGULATOR receiver
CGC63_RS14525	COG5002	protein histidine kinase activity
CGC63_RS14565	COG1309	transcriptional regulator
CGC63_RS14575	COG0084	hydrolase, TatD family'
CGC63_RS14580	COG0628	permease
CGC63_RS14585	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CGC63_RS14595	COG1115	amino acid carrier protein
CGC63_RS14615	COG0534	Mate efflux family protein
CGC63_RS14625	COG0640	Transcriptional regulator
CGC63_RS14630	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CGC63_RS14630	COG1918	ferrous iron import across plasma membrane
CGC63_RS14635	COG2217	Heavy metal translocating P-type atpase
CGC63_RS14655	COG0366	Alpha amylase catalytic
CGC63_RS14660	COG1876	peptidase activity
CGC63_RS14670	COG3850	Histidine kinase
CGC63_RS14670	COG5002	protein histidine kinase activity
CGC63_RS14680	COG1254	Belongs to the acylphosphatase family
CGC63_RS14685	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CGC63_RS14705	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CGC63_RS14710	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CGC63_RS14720	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CGC63_RS14720	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CGC63_RS14745	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CGC63_RS14765	COG2996	Protein conserved in bacteria
CGC63_RS14785	COG0534	Mate efflux family protein
CGC63_RS14795	COG2972	Histidine kinase
CGC63_RS14815	COG4753	response regulator
CGC63_RS14815	COG2207	Transcriptional regulator
CGC63_RS14870	COG0058	SHG alpha-glucan phosphorylase activity
CGC63_RS14875	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CGC63_RS14880	COG1686	Belongs to the peptidase S11 family
CGC63_RS14890	COG0081	regulation of translation
CGC63_RS14900	COG0250	Participates in transcription elongation, termination and antitermination
CGC63_RS14910	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CGC63_RS14915	COG0488	(ABC) transporter
CGC63_RS14920	COG0488	(ABC) transporter
CGC63_RS14925	COG0488	(ABC) transporter
CGC63_RS14945	COG1482	cell wall glycoprotein biosynthetic process
CGC63_RS14950	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CGC63_RS14965	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
CGC63_RS14970	COG1653	transport
CGC63_RS14975	COG0395	ABC-type sugar transport system, permease component
CGC63_RS14980	COG4209	transmembrane transport
CGC63_RS15005	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CGC63_RS15010	COG1621	beta-fructofuranosidase activity
CGC63_RS15020	COG3842	ATPase activity
CGC63_RS15025	COG0395	ABC-type sugar transport system, permease component
CGC63_RS15030	COG1175	transmembrane transport
CGC63_RS15065	COG3437	response regulator, receiver
CGC63_RS15105	COG4932	domain protein
CGC63_RS15105	COG3266	domain, Protein
CGC63_RS15105	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
CGC63_RS15145	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CGC63_RS15155	COG1475	DNA binding
CGC63_RS15160	COG1192	Involved in chromosome partitioning
CGC63_RS15190	COG0357	Ribosomal RNA small subunit methyltransferase G
CGC63_RS15195	COG0445	tRNA wobble uridine modification
CGC63_RS15200	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CGC63_RS15205	COG1847	R3H domain protein
CGC63_RS15210	COG0706	membrane insertase activity
CGC63_RS15220	COG0594	ribonuclease P activity
CGC63_RS15225	COG0230	Belongs to the bacterial ribosomal protein bL34 family