locus-tag	class	description
E5259_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E5259_RS00015	COG0594	ribonuclease P activity
E5259_RS00025	COG0706	membrane insertase activity
E5259_RS00030	COG1847	R3H domain protein
E5259_RS00035	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
E5259_RS00040	COG0445	tRNA wobble uridine modification
E5259_RS00045	COG0357	Ribosomal RNA small subunit methyltransferase G
E5259_RS00070	COG1131	(ABC) transporter
E5259_RS00095	COG1192	Involved in chromosome partitioning
E5259_RS00100	COG1475	DNA binding
E5259_RS00110	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
E5259_RS00125	COG2972	Histidine kinase
E5259_RS00130	COG4753	response regulator
E5259_RS00130	COG2207	Transcriptional regulator
E5259_RS00145	COG0395	ABC-type sugar transport system, permease component
E5259_RS00165	COG2186	Transcriptional regulator
E5259_RS00170	COG2271	Major facilitator Superfamily
E5259_RS00200	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E5259_RS00205	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E5259_RS00210	COG2972	Histidine kinase
E5259_RS00215	COG2201	protein-glutamate methylesterase activity
E5259_RS00225	COG1653	transport
E5259_RS00240	COG0473	3-isopropylmalate dehydrogenase activity
E5259_RS00240	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E5259_RS00255	COG2376	Dihydroxyacetone kinase
E5259_RS00265	COG0698	ribose 5-phosphate isomerase
E5259_RS00275	COG1063	alcohol dehydrogenase
E5259_RS00290	COG2721	sulfolactate sulfo-lyase activity
E5259_RS00300	COG0183	Belongs to the thiolase family
E5259_RS00305	COG1024	Enoyl-CoA hydratase
E5259_RS00310	COG1250	3-hydroxyacyl-CoA dehydrogenase
E5259_RS00315	COG1960	acyl-CoA dehydrogenase activity
E5259_RS00330	COG0004	ammonium transporteR
E5259_RS00335	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
E5259_RS00345	COG3426	butyrate kinase activity
E5259_RS00350	COG0280	phosphate acetyltransferase
E5259_RS00370	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E5259_RS00375	COG0444	Belongs to the ABC transporter superfamily
E5259_RS00380	COG4608	Belongs to the ABC transporter superfamily
E5259_RS00385	COG1053	succinate dehydrogenase
E5259_RS00405	COG3711	transcriptional antiterminator
E5259_RS00405	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E5259_RS00420	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E5259_RS00450	COG0667	Aldo Keto reductase
E5259_RS00455	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E5259_RS00485	COG0673	inositol 2-dehydrogenase activity
E5259_RS00495	COG0504	CTP synthase activity
E5259_RS00500	COG0067	glutamate synthase
E5259_RS00500	COG0069	glutamate synthase activity
E5259_RS00500	COG0070	glutamate synthase
E5259_RS00505	COG0493	'glutamate synthase
E5259_RS00515	COG0514	ATP-dependent DNA helicase (RecQ)
E5259_RS00535	COG0436	Aminotransferase
E5259_RS00540	COG0017	Asparaginyl-tRNA synthetase
E5259_RS00545	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E5259_RS00560	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E5259_RS00565	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E5259_RS00570	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E5259_RS00580	COG2176	DNA-directed DNA polymerase activity
E5259_RS00585	COG4753	response regulator
E5259_RS00585	COG2207	Transcriptional regulator
E5259_RS00590	COG2972	Histidine kinase
E5259_RS00595	COG1653	transport
E5259_RS00625	COG1686	Belongs to the peptidase S11 family
E5259_RS00630	COG2188	Transcriptional regulator
E5259_RS00635	COG1131	(ABC) transporter
E5259_RS00650	COG1609	Transcriptional regulator
E5259_RS00655	COG0366	Alpha amylase catalytic
E5259_RS00660	COG1653	transport
E5259_RS00665	COG1175	transmembrane transport
E5259_RS00670	COG0395	ABC-type sugar transport system, permease component
E5259_RS00675	COG1063	alcohol dehydrogenase
E5259_RS00680	COG1082	Xylose isomerase domain protein TIM barrel
E5259_RS00685	COG0673	inositol 2-dehydrogenase activity
E5259_RS00690	COG1554	hydrolase, family 65, central catalytic
E5259_RS00695	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E5259_RS00700	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
E5259_RS00705	COG0058	SHG alpha-glucan phosphorylase activity
E5259_RS00710	COG0583	DNA-binding transcription factor activity
E5259_RS00715	COG1288	antiporter activity
E5259_RS00720	COG2195	Cleaves the N-terminal amino acid of tripeptides
E5259_RS00735	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E5259_RS00740	COG1418	mRNA catabolic process
E5259_RS00745	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
E5259_RS00750	COG3842	ATPase activity
E5259_RS00770	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E5259_RS00770	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
E5259_RS00775	COG4977	sequence-specific DNA binding
E5259_RS00780	COG3250	beta-galactosidase activity
E5259_RS00785	COG2211	Major facilitator Superfamily
E5259_RS00800	COG2357	RelA SpoT domain protein
E5259_RS00825	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E5259_RS00830	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
E5259_RS00835	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E5259_RS00875	COG1122	ATPase activity
E5259_RS00885	COG4509	Sortase family
E5259_RS00905	COG2207	Transcriptional regulator
E5259_RS00905	COG3708	Transcriptional regulator
E5259_RS00915	COG1175	transmembrane transport
E5259_RS00920	COG0395	ABC-type sugar transport system, permease component
E5259_RS00930	COG1063	alcohol dehydrogenase
E5259_RS00940	COG2610	gluconate transmembrane transporter activity
E5259_RS00950	COG0129	dihydroxy-acid dehydratase activity
E5259_RS00955	COG1028	Short-chain dehydrogenase reductase Sdr
E5259_RS00960	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
E5259_RS00975	COG5002	protein histidine kinase activity
E5259_RS00980	COG0745	RESPONSE REGULATOR receiver
E5259_RS00995	COG0442	prolyl-tRNA aminoacylation
E5259_RS01000	COG1982	Orn Lys Arg decarboxylase major
E5259_RS01005	COG0194	GDP metabolic process
E5259_RS01015	COG1774	PSP1 C-terminal conserved region
E5259_RS01020	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
E5259_RS01025	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
E5259_RS01030	COG2843	Capsule synthesis protein
E5259_RS01035	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E5259_RS01040	COG2715	membrane protein required for spore maturation
E5259_RS01045	COG1609	Transcriptional regulator
E5259_RS01050	COG1609	Transcriptional regulator
E5259_RS01060	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E5259_RS01065	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E5259_RS01080	COG1028	Short-chain dehydrogenase reductase Sdr
E5259_RS01085	COG3959	Transketolase, thiamine diphosphate binding domain
E5259_RS01090	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
E5259_RS01095	COG1063	alcohol dehydrogenase
E5259_RS01100	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E5259_RS01110	COG0149	triose-phosphate isomerase activity
E5259_RS01135	COG0069	glutamate synthase activity
E5259_RS01140	COG0534	Mate efflux family protein
E5259_RS01155	COG1653	transport
E5259_RS01165	COG0395	ABC-type sugar transport system, permease component
E5259_RS01170	COG4753	response regulator
E5259_RS01170	COG2207	Transcriptional regulator
E5259_RS01175	COG2972	Histidine kinase
E5259_RS01180	COG1874	Beta-galactosidase
E5259_RS01205	COG3279	Response regulator of the LytR AlgR family
E5259_RS01220	COG3706	GGDEF domain
E5259_RS01230	COG2972	Histidine kinase
E5259_RS01235	COG4753	response regulator
E5259_RS01235	COG2207	Transcriptional regulator
E5259_RS01245	COG1175	transmembrane transport
E5259_RS01250	COG0395	ABC-type sugar transport system, permease component
E5259_RS01255	COG3345	alpha-galactosidase
E5259_RS01325	COG2365	Tyrosine phosphatase family
E5259_RS01330	COG0110	maltose O-acetyltransferase activity
E5259_RS01335	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
E5259_RS01340	COG0628	permease
E5259_RS01345	COG0084	hydrolase, TatD family'
E5259_RS01350	COG1309	transcriptional regulator
E5259_RS01370	COG0352	thiamine-phosphate diphosphorylase activity
E5259_RS01380	COG2022	thiamine diphosphate biosynthetic process
E5259_RS01385	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E5259_RS01395	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
E5259_RS01420	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
E5259_RS01430	COG1757	Na H antiporter
E5259_RS01435	COG0745	RESPONSE REGULATOR receiver
E5259_RS01445	COG1136	(ABC) transporter
E5259_RS01455	COG0523	cobalamin synthesis protein
E5259_RS01470	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
E5259_RS01495	COG1917	Cupin 2, conserved barrel domain protein
E5259_RS01495	COG4977	sequence-specific DNA binding
E5259_RS01510	COG0534	Mate efflux family protein
E5259_RS01515	COG0700	Nucleoside recognition
E5259_RS01520	COG2205	protein histidine kinase activity
E5259_RS01520	COG0784	Response regulator, receiver
E5259_RS01520	COG2198	Histidine kinase
E5259_RS01525	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
E5259_RS01530	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
E5259_RS01535	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E5259_RS01540	COG0131	Imidazoleglycerol-phosphate dehydratase
E5259_RS01545	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
E5259_RS01555	COG0107	imidazoleglycerol-phosphate synthase activity
E5259_RS01560	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
E5259_RS01565	COG0140	phosphoribosyl-ATP diphosphatase activity
E5259_RS01575	COG4869	propanediol catabolic process
E5259_RS01585	COG1105	Belongs to the carbohydrate kinase PfkB family
E5259_RS01590	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E5259_RS01590	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E5259_RS01590	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E5259_RS01595	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E5259_RS01600	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E5259_RS01605	COG1349	DNA-binding transcription factor activity
E5259_RS01610	COG1846	Transcriptional regulator
E5259_RS01625	COG0492	ferredoxin-NADP+ reductase activity
E5259_RS01635	COG1695	Transcriptional regulator
E5259_RS01645	COG5002	protein histidine kinase activity
E5259_RS01650	COG0745	RESPONSE REGULATOR receiver
E5259_RS01655	COG0704	Plays a role in the regulation of phosphate uptake
E5259_RS01660	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
E5259_RS01665	COG0581	inorganic phosphate transmembrane transporter activity
E5259_RS01670	COG0573	inorganic phosphate transmembrane transporter activity
E5259_RS01680	COG1394	ATPase activity, coupled to movement of substances
E5259_RS01710	COG1269	ATP hydrolysis coupled proton transport
E5259_RS01725	COG0220	tRNA (guanine-N7-)-methyltransferase activity
E5259_RS01770	COG0733	neurotransmitter:sodium symporter activity
E5259_RS01775	COG2201	protein-glutamate methylesterase activity
E5259_RS01780	COG3275	phosphorelay sensor kinase activity
E5259_RS01790	COG1175	transmembrane transport
E5259_RS01810	COG0281	malic enzyme
E5259_RS01815	COG3594	Acyltransferase
E5259_RS01830	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E5259_RS01840	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
E5259_RS01880	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
E5259_RS01890	COG5293	efflux transmembrane transporter activity
E5259_RS01895	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E5259_RS01900	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E5259_RS01900	COG0758	DNA mediated transformation
E5259_RS01990	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
E5259_RS02125	COG0741	lytic transglycosylase activity
E5259_RS02125	COG0791	NLP P60 protein
E5259_RS02135	COG1396	sequence-specific DNA binding
E5259_RS02155	COG1733	regulation of RNA biosynthetic process
E5259_RS02160	COG0778	Nitroreductase
E5259_RS02165	COG0640	Transcriptional regulator
E5259_RS02175	COG2217	Heavy metal translocating P-type atpase
E5259_RS02185	COG2217	Heavy metal translocating P-type atpase
E5259_RS02190	COG1937	Protein conserved in bacteria
E5259_RS02195	COG0534	Mate efflux family protein
E5259_RS02225	COG1476	TRANSCRIPTIONal
E5259_RS02235	COG1199	ATP-dependent helicase activity
E5259_RS02235	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E5259_RS02240	COG0582	viral genome integration into host DNA
E5259_RS02295	COG0705	Rhomboid family
E5259_RS02295	COG0457	Tetratricopeptide repeat
E5259_RS02300	COG3852	Histidine kinase
E5259_RS02305	COG0537	adenosine 5'-monophosphoramidase activity
E5259_RS02315	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E5259_RS02365	COG2197	response regulator
E5259_RS02370	COG4585	Histidine kinase
E5259_RS02375	COG1131	(ABC) transporter
E5259_RS02405	COG0784	Response regulator, receiver
E5259_RS02405	COG5002	protein histidine kinase activity
E5259_RS02410	COG4753	response regulator
E5259_RS02410	COG2207	Transcriptional regulator
E5259_RS02450	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E5259_RS02455	COG0831	urea catabolic process
E5259_RS02465	COG0804	urea catabolic process
E5259_RS02470	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
E5259_RS02475	COG0830	nickel cation binding
E5259_RS02485	COG0829	nickel cation binding
E5259_RS02585	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
E5259_RS02595	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
E5259_RS02630	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E5259_RS02635	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E5259_RS02645	COG0166	Belongs to the GPI family
E5259_RS02660	COG5002	protein histidine kinase activity
E5259_RS02665	COG3842	ATPase activity
E5259_RS02670	COG3835	regulator
E5259_RS02675	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
E5259_RS02680	COG0564	pseudouridine synthase activity
E5259_RS02700	COG1269	ATP hydrolysis coupled proton transport
E5259_RS02705	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
E5259_RS02720	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
E5259_RS02725	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
E5259_RS02730	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
E5259_RS02735	COG1394	ATPase activity, coupled to movement of substances
E5259_RS02745	COG2706	6-phosphogluconolactonase activity
E5259_RS02750	COG0534	Mate efflux family protein
E5259_RS02755	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
E5259_RS02765	COG0653	protein targeting
E5259_RS02775	COG1609	Transcriptional regulator
E5259_RS02785	COG0519	Catalyzes the synthesis of GMP from XMP
E5259_RS02800	COG4974	Belongs to the 'phage' integrase family
E5259_RS02850	COG3655	Transcriptional regulator
E5259_RS02890	COG0582	viral genome integration into host DNA
E5259_RS02925	COG1151	hydroxylamine reductase activity
E5259_RS02980	COG0582	viral genome integration into host DNA
E5259_RS03040	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E5259_RS03040	COG0551	DNA topoisomerase type I activity
E5259_RS03080	COG4474	Belongs to the UPF0398 family
E5259_RS03090	COG0756	dUTP diphosphatase activity
E5259_RS03135	COG0739	heme binding
E5259_RS03155	COG2088	sporulation resulting in formation of a cellular spore
E5259_RS03170	COG3344	reverse transcriptase
E5259_RS03305	COG1733	regulation of RNA biosynthetic process
E5259_RS03310	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E5259_RS03315	COG4605	iron ion homeostasis
E5259_RS03325	COG4607	ABC-type enterochelin transport system periplasmic component
E5259_RS03330	COG2186	Transcriptional regulator
E5259_RS03345	COG2211	Major facilitator Superfamily
E5259_RS03360	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
E5259_RS03365	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
E5259_RS03370	COG0813	purine-nucleoside phosphorylase activity
E5259_RS03375	COG2364	Membrane
E5259_RS03395	COG0737	Belongs to the 5'-nucleotidase family
E5259_RS03405	COG0534	Mate efflux family protein
E5259_RS03410	COG1309	transcriptional regulator
E5259_RS03415	COG1131	(ABC) transporter
E5259_RS03425	COG2814	Major facilitator Superfamily
E5259_RS03430	COG2267	carboxylic ester hydrolase activity
E5259_RS03435	COG3447	MASE1 domain protein
E5259_RS03435	COG5002	protein histidine kinase activity
E5259_RS03435	COG5001	Diguanylate cyclase
E5259_RS03445	COG0561	phosphatase activity
E5259_RS03450	COG4290	ribonuclease
E5259_RS03455	COG2732	(Barnase) inhibitor
E5259_RS03475	COG1595	DNA-templated transcription, initiation
E5259_RS03485	COG1131	(ABC) transporter
E5259_RS03515	COG2972	Histidine kinase
E5259_RS03520	COG4753	response regulator
E5259_RS03520	COG2207	Transcriptional regulator
E5259_RS03525	COG1472	Belongs to the glycosyl hydrolase 3 family
E5259_RS03545	COG5002	protein histidine kinase activity
E5259_RS03565	COG1971	Probably functions as a manganese efflux pump
E5259_RS03575	COG1115	amino acid carrier protein
E5259_RS03580	COG0726	polysaccharide deacetylase
E5259_RS03595	COG1012	belongs to the aldehyde dehydrogenase family
E5259_RS03595	COG1454	alcohol dehydrogenase
E5259_RS03600	COG1217	gtp-binding protein TYPA
E5259_RS03610	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
E5259_RS03615	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E5259_RS03620	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
E5259_RS03635	COG3708	Transcriptional regulator
E5259_RS03635	COG2207	Transcriptional regulator
E5259_RS03650	COG2188	Transcriptional regulator
E5259_RS03655	COG0653	protein targeting
E5259_RS03670	COG4492	Belongs to the UPF0735 family
E5259_RS03675	COG0460	homoserine dehydrogenase
E5259_RS03680	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
E5259_RS03690	COG1028	Short-chain dehydrogenase reductase Sdr
E5259_RS03710	COG0601	transmembrane transport
E5259_RS03715	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E5259_RS03720	COG0444	Belongs to the ABC transporter superfamily
E5259_RS03725	COG4608	Belongs to the ABC transporter superfamily
E5259_RS03740	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E5259_RS03745	COG1070	Carbohydrate kinase
E5259_RS03770	COG0745	RESPONSE REGULATOR receiver
E5259_RS03775	COG3850	Histidine kinase
E5259_RS03775	COG5002	protein histidine kinase activity
E5259_RS03795	COG1131	(ABC) transporter
E5259_RS03830	COG1070	Carbohydrate kinase
E5259_RS03835	COG2183	response to ionizing radiation
E5259_RS03840	COG0006	proline dipeptidase activity
E5259_RS03855	COG2207	Transcriptional regulator
E5259_RS03855	COG4753	response regulator
E5259_RS03860	COG1609	Transcriptional regulator
E5259_RS03865	COG4209	transmembrane transport
E5259_RS03870	COG0395	ABC-type sugar transport system, permease component
E5259_RS03920	COG1131	(ABC) transporter
E5259_RS03925	COG0534	Mate efflux family protein
E5259_RS03930	COG3250	beta-galactosidase activity
E5259_RS03995	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
E5259_RS04000	COG1028	Short-chain dehydrogenase reductase Sdr
E5259_RS04020	COG1028	Short-chain dehydrogenase reductase Sdr
E5259_RS04035	COG1653	transport
E5259_RS04045	COG0395	ABC-type sugar transport system, permease component
E5259_RS04060	COG3964	amidohydrolase
E5259_RS04070	COG2207	Transcriptional regulator
E5259_RS04070	COG4753	response regulator
E5259_RS04075	COG2972	Histidine kinase
E5259_RS04085	COG1175	transmembrane transport
E5259_RS04090	COG0395	ABC-type sugar transport system, permease component
E5259_RS04105	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
E5259_RS04110	COG0494	nUDIX hydrolase
E5259_RS04115	COG0628	permease
E5259_RS04120	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E5259_RS04125	COG0569	domain protein
E5259_RS04130	COG2205	protein histidine kinase activity
E5259_RS04135	COG0745	RESPONSE REGULATOR receiver
E5259_RS04140	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
E5259_RS04150	COG1696	Membrane protein involved in D-alanine export
E5259_RS04155	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E5259_RS04165	COG2759	Belongs to the formate--tetrahydrofolate ligase family
E5259_RS04170	COG2116	formate transmembrane transporter activity
E5259_RS04180	COG1132	(ABC) transporter
E5259_RS04185	COG0436	Aminotransferase
E5259_RS04205	COG1175	transmembrane transport
E5259_RS04215	COG2972	Histidine kinase
E5259_RS04220	COG2207	Transcriptional regulator
E5259_RS04220	COG4753	response regulator
E5259_RS04245	COG4209	transmembrane transport
E5259_RS04250	COG0395	ABC-type sugar transport system, permease component
E5259_RS04255	COG1940	carbohydrate kinase activity
E5259_RS04260	COG1653	transport
E5259_RS04265	COG1175	transmembrane transport
E5259_RS04280	COG1940	carbohydrate kinase activity
E5259_RS04285	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
E5259_RS04300	COG0622	Phosphoesterase
E5259_RS04305	COG0116	Belongs to the methyltransferase superfamily
E5259_RS04310	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
E5259_RS04315	COG0622	Phosphoesterase
E5259_RS04405	COG2508	Transcriptional regulator
E5259_RS04415	COG1609	Transcriptional regulator
E5259_RS04425	COG1175	transmembrane transport
E5259_RS04430	COG0395	ABC-type sugar transport system, permease component
E5259_RS04435	COG0673	inositol 2-dehydrogenase activity
E5259_RS04440	COG1063	alcohol dehydrogenase
E5259_RS04450	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E5259_RS04455	COG3962	Belongs to the TPP enzyme family
E5259_RS04480	COG2211	Major facilitator Superfamily
E5259_RS04490	COG0673	inositol 2-dehydrogenase activity
E5259_RS04495	COG2972	Histidine kinase
E5259_RS04500	COG2197	response regulator
E5259_RS04530	COG0673	inositol 2-dehydrogenase activity
E5259_RS04535	COG1082	Xylose isomerase domain protein TIM barrel
E5259_RS04540	COG1349	DNA-binding transcription factor activity
E5259_RS04545	COG2223	nitrite transmembrane transporter activity
E5259_RS04555	COG0662	Cupin 2, conserved barrel domain protein
E5259_RS04555	COG2207	Transcriptional regulator
E5259_RS04565	COG1175	transmembrane transport
E5259_RS04595	COG2986	histidine ammonia-lyase
E5259_RS04600	COG1757	Na H antiporter
E5259_RS04610	COG1773	rubredoxin
E5259_RS04615	COG0583	DNA-binding transcription factor activity
E5259_RS04620	COG0446	pyridine nucleotide-disulphide oxidoreductase
E5259_RS04630	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
E5259_RS04635	COG0534	Mate efflux family protein
E5259_RS04640	COG1328	CTP reductase activity
E5259_RS04640	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
E5259_RS04645	COG0475	glutathione-regulated potassium exporter activity
E5259_RS04670	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E5259_RS04680	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E5259_RS04690	COG5002	protein histidine kinase activity
E5259_RS04695	COG0745	RESPONSE REGULATOR receiver
E5259_RS04700	COG1193	negative regulation of DNA recombination
E5259_RS04705	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E5259_RS04710	COG3481	metal-dependent phosphohydrolase, HD sub domain
E5259_RS04715	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E5259_RS04730	COG0596	Alpha beta hydrolase
E5259_RS04730	COG2945	thiolester hydrolase activity
E5259_RS04750	COG0454	-acetyltransferase
E5259_RS04765	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
E5259_RS04775	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
E5259_RS04780	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
E5259_RS04805	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E5259_RS04810	COG2946	Replication initiation factor
E5259_RS04830	COG1595	DNA-templated transcription, initiation
E5259_RS04840	COG1121	(ABC) transporter
E5259_RS04865	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
E5259_RS04870	COG1687	branched-chain amino acid
E5259_RS04915	COG1215	transferase activity, transferring glycosyl groups
E5259_RS04920	COG4251	negative regulation of phosphorylation
E5259_RS04920	COG2203	Gaf domain
E5259_RS04920	COG5001	Diguanylate cyclase
E5259_RS04920	COG3706	GGDEF domain
E5259_RS04940	COG2252	PERMEase
E5259_RS04955	COG0572	uridine kinase
E5259_RS04960	COG1940	carbohydrate kinase activity
E5259_RS04965	COG1609	Transcriptional regulator
E5259_RS04970	COG1082	Xylose isomerase domain protein TIM barrel
E5259_RS04975	COG1869	D-ribose catabolic process
E5259_RS04980	COG1063	alcohol dehydrogenase
E5259_RS04990	COG1175	transmembrane transport
E5259_RS04995	COG0395	ABC-type sugar transport system, permease component
E5259_RS05020	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
E5259_RS05025	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
E5259_RS05030	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E5259_RS05070	COG2801	Transposase and inactivated derivatives
E5259_RS05080	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
E5259_RS05085	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
E5259_RS05090	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
E5259_RS05095	COG2205	protein histidine kinase activity
E5259_RS05125	COG2205	protein histidine kinase activity
E5259_RS05130	COG0745	RESPONSE REGULATOR receiver
E5259_RS05160	COG0534	Mate efflux family protein
E5259_RS05165	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
E5259_RS05180	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
E5259_RS05190	COG0157	Belongs to the NadC ModD family
E5259_RS05195	COG1827	regulation of RNA biosynthetic process
E5259_RS05210	COG2972	Histidine kinase
E5259_RS05220	COG1175	transmembrane transport
E5259_RS05225	COG0395	ABC-type sugar transport system, permease component
E5259_RS05230	COG2207	Transcriptional regulator
E5259_RS05230	COG4753	response regulator
E5259_RS05235	COG0673	inositol 2-dehydrogenase activity
E5259_RS05240	COG0456	acetyltransferase
E5259_RS05245	COG1283	sodium-dependent phosphate transmembrane transporter activity
E5259_RS05255	COG5002	protein histidine kinase activity
E5259_RS05280	COG3546	catalase activity
E5259_RS05290	COG0569	domain protein
E5259_RS05300	COG2217	Heavy metal translocating P-type atpase
E5259_RS05310	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
E5259_RS05320	COG1476	TRANSCRIPTIONal
E5259_RS05330	COG4152	abc transporter atp-binding protein
E5259_RS05335	COG1668	transmembrane transport
E5259_RS05340	COG0363	glucosamine-6-phosphate deaminase activity
E5259_RS05390	COG3646	Phage regulatory protein
E5259_RS05390	COG3645	SOS response
E5259_RS05435	COG0358	DNA primase activity
E5259_RS05495	COG3728	DNA packaging
E5259_RS05515	COG3118	belongs to the thioredoxin family
E5259_RS05705	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E5259_RS05710	COG4868	Belongs to the UPF0371 family
E5259_RS05715	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E5259_RS05720	COG0322	excinuclease ABC activity
E5259_RS05725	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
E5259_RS05730	COG1940	carbohydrate kinase activity
E5259_RS05740	COG1739	Uncharacterized protein family UPF0029
E5259_RS05745	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E5259_RS05750	COG0802	atpase or kinase
E5259_RS05755	COG1214	PFAM Peptidase M22, glycoprotease
E5259_RS05760	COG0456	acetyltransferase
E5259_RS05770	COG1234	tRNA 3'-trailer cleavage
E5259_RS05780	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
E5259_RS05835	COG0242	peptide deformylase activity
E5259_RS05865	COG3408	Glycogen debranching enzyme
E5259_RS05870	COG0745	RESPONSE REGULATOR receiver
E5259_RS05885	COG2205	protein histidine kinase activity
E5259_RS05930	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
E5259_RS05930	COG2508	Transcriptional regulator
E5259_RS05970	COG1595	DNA-templated transcription, initiation
E5259_RS05980	COG1131	(ABC) transporter
E5259_RS05995	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E5259_RS06005	COG1131	(ABC) transporter
E5259_RS06040	COG1131	(ABC) transporter
E5259_RS06065	COG0745	RESPONSE REGULATOR receiver
E5259_RS06070	COG2205	protein histidine kinase activity
E5259_RS06085	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E5259_RS06100	COG2738	Putative neutral zinc metallopeptidase
E5259_RS06105	COG2207	Transcriptional regulator
E5259_RS06110	COG5012	cobalamin binding
E5259_RS06115	COG5598	trimethylamine methyltransferase
E5259_RS06125	COG1414	Transcriptional regulator
E5259_RS06130	COG5598	trimethylamine methyltransferase
E5259_RS06160	COG0251	oxidation-reduction process
E5259_RS06200	COG1136	(ABC) transporter
E5259_RS06200	COG0577	efflux transmembrane transporter activity
E5259_RS06205	COG1879	ABC-type sugar transport system periplasmic component
E5259_RS06210	COG1129	ABC transporter
E5259_RS06215	COG4211	Belongs to the binding-protein-dependent transport system permease family
E5259_RS06225	COG2972	Histidine kinase
E5259_RS06240	COG1136	(ABC) transporter
E5259_RS06250	COG2211	Major facilitator Superfamily
E5259_RS06255	COG2207	Transcriptional regulator
E5259_RS06255	COG1609	Transcriptional regulator
E5259_RS06260	COG1609	Transcriptional regulator
E5259_RS06265	COG0673	inositol 2-dehydrogenase activity
E5259_RS06280	COG1082	Xylose isomerase domain protein TIM barrel
E5259_RS06285	COG1082	Xylose isomerase domain protein TIM barrel
E5259_RS06295	COG1595	DNA-templated transcription, initiation
E5259_RS06305	COG1131	(ABC) transporter
E5259_RS06315	COG1131	(ABC) transporter
E5259_RS06385	COG1720	tRNA m6t6A37 methyltransferase activity
E5259_RS06390	COG0367	asparagine synthase
E5259_RS06395	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
E5259_RS06410	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
E5259_RS06420	COG3708	Transcriptional regulator
E5259_RS06420	COG2207	Transcriptional regulator
E5259_RS06440	COG3250	beta-galactosidase activity
E5259_RS06445	COG1874	Beta-galactosidase
E5259_RS06455	COG1380	Effector of murein hydrolase LrgA
E5259_RS06460	COG1346	cytolysis
E5259_RS06470	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E5259_RS06475	COG1609	Transcriptional regulator
E5259_RS06490	COG1175	transmembrane transport
E5259_RS06495	COG0395	ABC-type sugar transport system, permease component
E5259_RS06505	COG1609	Transcriptional regulator
E5259_RS06515	COG3959	Transketolase, thiamine diphosphate binding domain
E5259_RS06520	COG3958	Transketolase
E5259_RS06525	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E5259_RS06545	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E5259_RS06550	COG1132	(ABC) transporter
E5259_RS06555	COG1132	(ABC) transporter
E5259_RS06570	COG4372	Transposase
E5259_RS06580	COG0534	Mate efflux family protein
E5259_RS06585	COG4372	Transposase
E5259_RS06605	COG5001	Diguanylate cyclase
E5259_RS06605	COG4251	negative regulation of phosphorylation
E5259_RS06605	COG3706	GGDEF domain
E5259_RS06605	COG2203	Gaf domain
E5259_RS06610	COG0582	viral genome integration into host DNA
E5259_RS06630	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E5259_RS06635	COG0151	Belongs to the GarS family
E5259_RS06665	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
E5259_RS06685	COG0194	GDP metabolic process
E5259_RS06695	COG2217	Heavy metal translocating P-type atpase
E5259_RS06710	COG5598	trimethylamine methyltransferase
E5259_RS06725	COG0686	Belongs to the AlaDH PNT family
E5259_RS06730	COG1115	amino acid carrier protein
E5259_RS06745	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
E5259_RS06750	COG4974	Belongs to the 'phage' integrase family
E5259_RS06760	COG1501	Belongs to the glycosyl hydrolase 31 family
E5259_RS06765	COG2188	Transcriptional regulator
E5259_RS06770	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
E5259_RS06775	COG3845	ABC transporter
E5259_RS06780	COG4603	Belongs to the binding-protein-dependent transport system permease family
E5259_RS06785	COG1079	Belongs to the binding-protein-dependent transport system permease family
E5259_RS06790	COG1744	ABC transporter substrate-binding protein PnrA-like
E5259_RS06805	COG0295	cytidine deaminase activity
E5259_RS06820	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
E5259_RS06840	COG1268	BioY protein
E5259_RS06845	COG4753	response regulator
E5259_RS06845	COG2207	Transcriptional regulator
E5259_RS06850	COG2972	Histidine kinase
E5259_RS06860	COG1175	transmembrane transport
E5259_RS06865	COG0395	ABC-type sugar transport system, permease component
E5259_RS06875	COG0667	Aldo Keto reductase
E5259_RS06880	COG3250	beta-galactosidase activity
E5259_RS06910	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E5259_RS06915	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E5259_RS06920	COG0110	maltose O-acetyltransferase activity
E5259_RS06935	COG1086	Polysaccharide biosynthesis protein
E5259_RS06960	COG0438	transferase activity, transferring glycosyl groups
E5259_RS06965	COG1216	Glycosyl transferase, family 2
E5259_RS06965	COG1442	glycosyl transferase family 8
E5259_RS06975	COG1442	glycosyl transferase family 8
E5259_RS06975	COG1216	Glycosyl transferase, family 2
E5259_RS06985	COG1083	cytidylyl-transferase
E5259_RS06990	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E5259_RS07000	COG0546	phosphoglycolate phosphatase activity
E5259_RS07010	COG0562	UDP-galactopyranose mutase
E5259_RS07035	COG1288	antiporter activity
E5259_RS07045	COG0588	phosphoglycerate mutase activity
E5259_RS07060	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
E5259_RS07070	COG3314	Sporulation integral membrane protein YlbJ
E5259_RS07075	COG2986	histidine ammonia-lyase
E5259_RS07085	COG2972	Histidine kinase
E5259_RS07090	COG2207	Transcriptional regulator
E5259_RS07090	COG4753	response regulator
E5259_RS07100	COG1175	transmembrane transport
E5259_RS07105	COG0395	ABC-type sugar transport system, permease component
E5259_RS07130	COG0275	rRNA processing
E5259_RS07135	COG1408	metallophosphoesterase
E5259_RS07140	COG0110	maltose O-acetyltransferase activity
E5259_RS07150	COG0366	Alpha amylase catalytic
E5259_RS07160	COG1472	Belongs to the glycosyl hydrolase 3 family
E5259_RS07175	COG4509	Sortase family
E5259_RS07190	COG0360	Binds together with S18 to 16S ribosomal RNA
E5259_RS07195	COG0629	single-stranded DNA binding
E5259_RS07200	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
E5259_RS07215	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
E5259_RS07220	COG0359	binds to the 23S rRNA
E5259_RS07225	COG0305	Participates in initiation and elongation during chromosome replication
E5259_RS07245	COG1476	TRANSCRIPTIONal
E5259_RS07280	COG1459	type II secretion system
E5259_RS07290	COG0322	excinuclease ABC activity
E5259_RS07295	COG0745	RESPONSE REGULATOR receiver
E5259_RS07300	COG5002	protein histidine kinase activity
E5259_RS07320	COG0268	Binds directly to 16S ribosomal RNA
E5259_RS07325	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
E5259_RS07335	COG0481	GTPase activity
E5259_RS07340	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E5259_RS07360	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E5259_RS07365	COG1040	competence protein
E5259_RS07380	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
E5259_RS07405	COG1376	ErfK ybiS ycfS ynhG family protein
E5259_RS07410	COG0151	Belongs to the GarS family
E5259_RS07420	COG0463	Glycosyl transferase, family 2
E5259_RS07435	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E5259_RS07450	COG1442	glycosyl transferase family 8
E5259_RS07455	COG0562	UDP-galactopyranose mutase
E5259_RS07460	COG3475	LICD family
E5259_RS07490	COG1686	Belongs to the peptidase S11 family
E5259_RS07495	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
E5259_RS07500	COG1682	transport, permease protein
E5259_RS07525	COG0438	transferase activity, transferring glycosyl groups
E5259_RS07525	COG1216	Glycosyl transferase, family 2
E5259_RS07535	COG0463	Glycosyl transferase, family 2
E5259_RS07540	COG0438	transferase activity, transferring glycosyl groups
E5259_RS07540	COG1216	Glycosyl transferase, family 2
E5259_RS07545	COG1216	Glycosyl transferase, family 2
E5259_RS07550	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E5259_RS07560	COG3475	LICD family
E5259_RS07580	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
E5259_RS07585	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
E5259_RS07635	COG1484	DNA-dependent DNA replication
E5259_RS07695	COG1968	undecaprenyl-diphosphatase activity
E5259_RS07700	COG1902	pentaerythritol trinitrate reductase activity
E5259_RS07700	COG0446	pyridine nucleotide-disulphide oxidoreductase
E5259_RS07720	COG0549	Belongs to the carbamate kinase family
E5259_RS07725	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E5259_RS07730	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E5259_RS07750	COG0820	rRNA (adenine-C2-)-methyltransferase activity
E5259_RS07755	COG0631	protein serine/threonine phosphatase activity
E5259_RS07770	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E5259_RS07775	COG1564	THIamine pyrophosphokinase
E5259_RS07780	COG0012	GTP binding
E5259_RS07795	COG2001	Belongs to the MraZ family
E5259_RS07810	COG0768	penicillin binding
E5259_RS07815	COG0768	penicillin binding
E5259_RS07825	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
E5259_RS07830	COG0772	Belongs to the SEDS family
E5259_RS07835	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E5259_RS07855	COG0521	Mo-molybdopterin cofactor biosynthetic process
E5259_RS07875	COG0710	3-dehydroquinate dehydratase activity
E5259_RS07885	COG1191	sigma factor activity
E5259_RS07890	COG1414	Transcriptional regulator
E5259_RS07895	COG0800	Aldolase
E5259_RS07905	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E5259_RS07920	COG3534	alpha-L-arabinofuranosidase
E5259_RS07925	COG1968	undecaprenyl-diphosphatase activity
E5259_RS07935	COG1191	sigma factor activity
E5259_RS07940	COG0673	inositol 2-dehydrogenase activity
E5259_RS07945	COG1653	transport
E5259_RS07950	COG1175	transmembrane transport
E5259_RS07955	COG0395	ABC-type sugar transport system, permease component
E5259_RS07960	COG3275	phosphorelay sensor kinase activity
E5259_RS07965	COG2197	response regulator
E5259_RS07985	COG1363	Peptidase, m42
E5259_RS07990	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
E5259_RS08000	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
E5259_RS08015	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E5259_RS08020	COG0444	Belongs to the ABC transporter superfamily
E5259_RS08025	COG4608	Belongs to the ABC transporter superfamily
E5259_RS08030	COG0436	Aminotransferase
E5259_RS08040	COG0534	Mate efflux family protein
E5259_RS08055	COG1132	(ABC) transporter
E5259_RS08060	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
E5259_RS08070	COG0640	Transcriptional regulator
E5259_RS08075	COG0372	Belongs to the citrate synthase family
E5259_RS08080	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
E5259_RS08085	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
E5259_RS08105	COG0726	polysaccharide deacetylase
E5259_RS08110	COG1187	pseudouridine synthase activity
E5259_RS08115	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E5259_RS08120	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E5259_RS08125	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
E5259_RS08145	COG0753	catalase activity
E5259_RS08150	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
E5259_RS08155	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E5259_RS08160	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E5259_RS08175	COG1846	Transcriptional regulator
E5259_RS08190	COG0583	DNA-binding transcription factor activity
E5259_RS08195	COG0019	diaminopimelate decarboxylase activity
E5259_RS08200	COG0488	(ABC) transporter
E5259_RS08205	COG1959	2 iron, 2 sulfur cluster binding
E5259_RS08220	COG0584	glycerophosphoryl diester phosphodiesterase
E5259_RS08240	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
E5259_RS08245	COG1381	Involved in DNA repair and RecF pathway recombination
E5259_RS08250	COG0423	glycine-tRNA ligase activity
E5259_RS08255	COG1609	Transcriptional regulator
E5259_RS08260	COG1621	beta-fructofuranosidase activity
E5259_RS08265	COG1653	transport
E5259_RS08270	COG1175	transmembrane transport
E5259_RS08275	COG0395	ABC-type sugar transport system, permease component
E5259_RS08300	COG0205	6-phosphofructokinase activity
E5259_RS08305	COG2972	Histidine kinase
E5259_RS08315	COG1653	transport
E5259_RS08320	COG1175	transmembrane transport
E5259_RS08325	COG0395	ABC-type sugar transport system, permease component
E5259_RS08330	COG4753	response regulator
E5259_RS08330	COG2207	Transcriptional regulator
E5259_RS08335	COG3681	Belongs to the UPF0597 family
E5259_RS08345	COG4989	oxidoreductase activity
E5259_RS08350	COG0574	Belongs to the PEP-utilizing enzyme family
E5259_RS08350	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E5259_RS08355	COG1917	Cupin 2, conserved barrel domain protein
E5259_RS08355	COG4977	sequence-specific DNA binding
E5259_RS08365	COG1609	Transcriptional regulator
E5259_RS08385	COG1183	phosphatidylcholine synthase activity
E5259_RS08390	COG0688	phosphatidylethanolamine metabolic process
E5259_RS08400	COG1285	pathogenesis
E5259_RS08410	COG2378	regulation of single-species biofilm formation
E5259_RS08420	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E5259_RS08430	COG0513	Belongs to the DEAD box helicase family
E5259_RS08435	COG1501	Belongs to the glycosyl hydrolase 31 family
E5259_RS08450	COG1979	alcohol dehydrogenase
E5259_RS08460	COG2032	superoxide dismutase activity
E5259_RS08465	COG3546	catalase activity
E5259_RS08560	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E5259_RS08560	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E5259_RS08610	COG1192	Involved in chromosome partitioning
E5259_RS08625	COG5484	DNA packaging
E5259_RS08840	COG2207	Transcriptional regulator
E5259_RS08840	COG1917	Cupin 2, conserved barrel domain protein
E5259_RS08855	COG4948	Mandelate Racemase Muconate Lactonizing
E5259_RS08860	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E5259_RS08870	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
E5259_RS08870	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E5259_RS08875	COG1063	alcohol dehydrogenase
E5259_RS08880	COG1028	Short-chain dehydrogenase reductase Sdr
E5259_RS08900	COG3546	catalase activity
E5259_RS08930	COG0584	glycerophosphoryl diester phosphodiesterase
E5259_RS08935	COG0772	Belongs to the SEDS family
E5259_RS08940	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E5259_RS08945	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
E5259_RS08955	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E5259_RS08960	COG0511	ligase activity, forming carbon-carbon bonds
E5259_RS08965	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E5259_RS08970	COG0439	Biotin carboxylase
E5259_RS08980	COG2070	2-Nitropropane dioxygenase
E5259_RS09000	COG4753	response regulator
E5259_RS09000	COG2207	Transcriptional regulator
E5259_RS09005	COG2972	Histidine kinase
E5259_RS09010	COG1175	transmembrane transport
E5259_RS09015	COG0395	ABC-type sugar transport system, permease component
E5259_RS09020	COG1501	Belongs to the glycosyl hydrolase 31 family
E5259_RS09035	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E5259_RS09040	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
E5259_RS09045	COG2080	2 iron, 2 sulfur cluster binding
E5259_RS09060	COG1653	transport
E5259_RS09070	COG0395	ABC-type sugar transport system, permease component
E5259_RS09085	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E5259_RS09090	COG0210	DNA helicase
E5259_RS09100	COG0667	Aldo Keto reductase
E5259_RS09105	COG0789	Transcriptional regulator
E5259_RS09105	COG4978	Transcriptional regulator
E5259_RS09110	COG2207	Transcriptional regulator
E5259_RS09110	COG1609	Transcriptional regulator
E5259_RS09125	COG3854	ATPases associated with a variety of cellular activities
E5259_RS09165	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
E5259_RS09175	COG2894	cell division
E5259_RS09210	COG1302	Protein conserved in bacteria
E5259_RS09215	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E5259_RS09220	COG1570	exodeoxyribonuclease VII activity
E5259_RS09225	COG1722	exodeoxyribonuclease VII activity
E5259_RS09235	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
E5259_RS09240	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
E5259_RS09245	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
E5259_RS09250	COG1438	arginine binding
E5259_RS09255	COG0497	DNA recombination
E5259_RS09260	COG0750	zinc metalloprotease
E5259_RS09265	COG0745	RESPONSE REGULATOR receiver
E5259_RS09270	COG0297	glycogen (starch) synthase activity
E5259_RS09275	COG0745	RESPONSE REGULATOR receiver
E5259_RS09280	COG5002	protein histidine kinase activity
E5259_RS09285	COG0446	pyridine nucleotide-disulphide oxidoreductase
E5259_RS09295	COG1136	(ABC) transporter
E5259_RS09315	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
E5259_RS09320	COG2137	regulation of response to DNA damage stimulus
E5259_RS09325	COG1418	mRNA catabolic process
E5259_RS09335	COG4974	Belongs to the 'phage' integrase family
E5259_RS09340	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E5259_RS09345	COG2244	polysaccharide biosynthetic process
E5259_RS09350	COG1959	2 iron, 2 sulfur cluster binding
E5259_RS09360	COG0822	iron-sulfur transferase activity
E5259_RS09365	COG0482	sulfurtransferase activity
E5259_RS09380	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
E5259_RS09395	COG0149	triose-phosphate isomerase activity
E5259_RS09410	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E5259_RS09415	COG0765	amino acid transport
E5259_RS09420	COG1126	abc transporter atp-binding protein
E5259_RS09425	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
E5259_RS09430	COG4977	sequence-specific DNA binding
E5259_RS09465	COG0148	phosphopyruvate hydratase activity
E5259_RS09470	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E5259_RS09475	COG0557	exoribonuclease II activity
E5259_RS09480	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
E5259_RS09510	COG2205	protein histidine kinase activity
E5259_RS09535	COG0745	RESPONSE REGULATOR receiver
E5259_RS09540	COG5002	protein histidine kinase activity
E5259_RS09560	COG0343	queuine tRNA-ribosyltransferase activity
E5259_RS09570	COG1760	l-serine dehydratase
E5259_RS09575	COG1760	l-serine dehydratase
E5259_RS09580	COG3708	Transcriptional regulator
E5259_RS09580	COG2207	Transcriptional regulator
E5259_RS09585	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E5259_RS09585	COG0493	'glutamate synthase
E5259_RS09610	COG0129	dihydroxy-acid dehydratase activity
E5259_RS09615	COG0028	Belongs to the TPP enzyme family
E5259_RS09620	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
E5259_RS09625	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E5259_RS09640	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
E5259_RS09650	COG1160	GTP binding
E5259_RS09655	COG0456	acetyltransferase
E5259_RS09675	COG1309	transcriptional regulator
E5259_RS09690	COG0517	IMP dehydrogenase activity
E5259_RS09690	COG0516	GMP reductase activity
E5259_RS09695	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
E5259_RS09700	COG0668	transmembrane transport
E5259_RS09730	COG3842	ATPase activity
E5259_RS09740	COG1177	transmembrane transport
E5259_RS09765	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E5259_RS09770	COG3279	Response regulator of the LytR AlgR family
E5259_RS09795	COG3842	ATPase activity
E5259_RS09820	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E5259_RS09825	COG1116	anion transmembrane transporter activity
E5259_RS09830	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E5259_RS09840	COG0165	Argininosuccinate lyase
E5259_RS09855	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
E5259_RS09860	COG1309	transcriptional regulator
E5259_RS09890	COG0438	transferase activity, transferring glycosyl groups
E5259_RS09895	COG0438	transferase activity, transferring glycosyl groups
E5259_RS09925	COG3383	formate dehydrogenase (NAD+) activity
E5259_RS09935	COG0746	molybdenum cofactor guanylyltransferase activity
E5259_RS09960	COG1725	Transcriptional regulator
E5259_RS09965	COG1131	(ABC) transporter
E5259_RS09975	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
E5259_RS10020	COG1136	(ABC) transporter
E5259_RS10025	COG0577	efflux transmembrane transporter activity
E5259_RS10045	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
E5259_RS10055	COG2205	protein histidine kinase activity
E5259_RS10055	COG2198	Histidine kinase
E5259_RS10055	COG0784	Response regulator, receiver
E5259_RS10070	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E5259_RS10080	COG0534	Mate efflux family protein
E5259_RS10100	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
E5259_RS10110	COG0733	neurotransmitter:sodium symporter activity
E5259_RS10120	COG0528	UMP kinase activity
E5259_RS10125	COG0233	cytoplasmic translational termination
E5259_RS10130	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E5259_RS10135	COG4589	Belongs to the CDS family
E5259_RS10145	COG0750	zinc metalloprotease
E5259_RS10155	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
E5259_RS10205	COG1484	DNA-dependent DNA replication
E5259_RS10210	COG4584	PFAM Integrase catalytic
E5259_RS10215	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E5259_RS10220	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E5259_RS10225	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E5259_RS10225	COG0512	Glutamine amidotransferase of anthranilate synthase
E5259_RS10240	COG1609	Transcriptional regulator
E5259_RS10250	COG1175	transmembrane transport
E5259_RS10255	COG0395	ABC-type sugar transport system, permease component
E5259_RS10260	COG1554	hydrolase, family 65, central catalytic
E5259_RS10265	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E5259_RS10270	COG0366	Alpha amylase catalytic
E5259_RS10280	COG3177	Filamentation induced by cAMP protein fic
E5259_RS10285	COG3177	Filamentation induced by cAMP protein fic
E5259_RS10300	COG3119	arylsulfatase activity
E5259_RS10310	COG3328	transposase activity
E5259_RS10315	COG0582	viral genome integration into host DNA
E5259_RS10360	COG3842	ATPase activity
E5259_RS10370	COG1175	transmembrane transport
E5259_RS10375	COG0584	glycerophosphoryl diester phosphodiesterase
E5259_RS10400	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E5259_RS10405	COG3158	transport of potassium into the cell
E5259_RS10410	COG1396	sequence-specific DNA binding
E5259_RS10440	COG4977	sequence-specific DNA binding
E5259_RS10455	COG1175	transmembrane transport
E5259_RS10460	COG0395	ABC-type sugar transport system, permease component
E5259_RS10470	COG2972	Histidine kinase
E5259_RS10475	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
E5259_RS10480	COG0232	Belongs to the dGTPase family. Type 2 subfamily
E5259_RS10485	COG0358	DNA primase activity
E5259_RS10490	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E5259_RS10520	COG0077	Prephenate dehydratase
E5259_RS10520	COG1605	Chorismate mutase
E5259_RS10525	COG1136	(ABC) transporter
E5259_RS10535	COG0745	RESPONSE REGULATOR receiver
E5259_RS10540	COG0642	Histidine kinase
E5259_RS10550	COG0540	Belongs to the ATCase OTCase family
E5259_RS10565	COG0534	Mate efflux family protein
E5259_RS10585	COG0697	spore germination
E5259_RS10600	COG0725	ABC transporter, periplasmic molybdate-binding protein
E5259_RS10605	COG4149	molybdate abc transporter
E5259_RS10615	COG1522	sequence-specific DNA binding
E5259_RS10620	COG0436	Aminotransferase
E5259_RS10625	COG0527	aspartate kinase activity
E5259_RS10630	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E5259_RS10640	COG0824	Thioesterase
E5259_RS10645	COG1725	Transcriptional regulator
E5259_RS10650	COG4152	abc transporter atp-binding protein
E5259_RS10675	COG1607	acyl-coa hydrolase
E5259_RS10685	COG0237	dephospho-CoA kinase activity
E5259_RS10690	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
E5259_RS10700	COG2848	UPF0210 protein
E5259_RS10715	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
E5259_RS10715	COG1918	ferrous iron import across plasma membrane
E5259_RS10725	COG1323	Belongs to the UPF0348 family
E5259_RS10740	COG0333	Belongs to the bacterial ribosomal protein bL32 family
E5259_RS10750	COG0416	fatty acid biosynthetic process
E5259_RS10755	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E5259_RS10760	COG0571	ribonuclease III activity
E5259_RS10765	COG1196	nuclear chromosome segregation
E5259_RS10770	COG0552	protein localization to endoplasmic reticulum
E5259_RS10775	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E5259_RS10790	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
E5259_RS10795	COG1606	tRNA processing
E5259_RS10815	COG0758	DNA mediated transformation
E5259_RS10825	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E5259_RS10835	COG1837	Belongs to the UPF0109 family
E5259_RS10840	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
E5259_RS10845	COG0336	Belongs to the RNA methyltransferase TrmD family
E5259_RS10865	COG0438	transferase activity, transferring glycosyl groups
E5259_RS10875	COG0535	radical SAM domain protein
E5259_RS10895	COG0110	maltose O-acetyltransferase activity
E5259_RS10995	COG4464	protein tyrosine phosphatase activity
E5259_RS11010	COG4509	Sortase family
E5259_RS11015	COG1316	TRANSCRIPTIONal
E5259_RS11030	COG4978	Transcriptional regulator
E5259_RS11030	COG0789	Transcriptional regulator
E5259_RS11035	COG1091	dTDP-4-dehydrorhamnose reductase activity
E5259_RS11050	COG0335	large ribosomal subunit rRNA binding
E5259_RS11055	COG0681	Belongs to the peptidase S26 family
E5259_RS11065	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
E5259_RS11070	COG0792	nuclease activity
E5259_RS11075	COG1496	oxidoreductase activity
E5259_RS11085	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E5259_RS11095	COG1160	GTP binding
E5259_RS11100	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
E5259_RS11105	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
E5259_RS11110	COG1136	(ABC) transporter
E5259_RS11110	COG0577	efflux transmembrane transporter activity
E5259_RS11120	COG0577	efflux transmembrane transporter activity
E5259_RS11120	COG1136	(ABC) transporter
E5259_RS11125	COG0656	L-ascorbic acid biosynthetic process
E5259_RS11130	COG0420	3'-5' exonuclease activity
E5259_RS11150	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
E5259_RS11160	COG1151	hydroxylamine reductase activity
E5259_RS11205	COG3404	Formiminotransferase-cyclodeaminase
E5259_RS11210	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
E5259_RS11215	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E5259_RS11220	COG3885	ferrous iron binding
E5259_RS11220	COG2078	PFAM AMMECR1 domain protein
E5259_RS11240	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
E5259_RS11245	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
E5259_RS11280	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
E5259_RS11290	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
E5259_RS11310	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E5259_RS11315	COG1492	cobalamin metabolic process
E5259_RS11345	COG0310	cobalt ion transport
E5259_RS11350	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
E5259_RS11355	COG1648	precorrin-2 dehydrogenase activity
E5259_RS11355	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E5259_RS11365	COG0113	porphobilinogen synthase activity
E5259_RS11370	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
E5259_RS11380	COG0328	RNA-DNA hybrid ribonuclease activity
E5259_RS11395	COG2211	Major facilitator Superfamily
E5259_RS11400	COG2226	methyltransferase
E5259_RS11415	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E5259_RS11420	COG0828	Belongs to the bacterial ribosomal protein bS21 family
E5259_RS11425	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E5259_RS11440	COG1686	Belongs to the peptidase S11 family
E5259_RS11445	COG0534	Mate efflux family protein
E5259_RS11450	COG1408	metallophosphoesterase
E5259_RS11455	COG0714	Associated with various cellular activities
E5259_RS11475	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
E5259_RS11485	COG2270	Major facilitator Superfamily
E5259_RS11490	COG1686	Belongs to the peptidase S11 family
E5259_RS11525	COG1674	ftsk spoiiie
E5259_RS11530	COG2946	Replication initiation factor
E5259_RS11575	COG0741	lytic transglycosylase activity
E5259_RS11575	COG0791	NLP P60 protein
E5259_RS11585	COG1131	(ABC) transporter
E5259_RS11615	COG1733	regulation of RNA biosynthetic process
E5259_RS11650	COG0582	viral genome integration into host DNA
E5259_RS11655	COG0071	Belongs to the small heat shock protein (HSP20) family
E5259_RS11670	COG3852	Histidine kinase
E5259_RS11675	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
E5259_RS11680	COG1022	Amp-dependent synthetase and ligase
E5259_RS11685	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E5259_RS11690	COG2084	Dehydrogenase
E5259_RS11710	COG1115	amino acid carrier protein
E5259_RS11730	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E5259_RS11750	COG0512	Glutamine amidotransferase of anthranilate synthase
E5259_RS11750	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E5259_RS11755	COG0134	indole-3-glycerol-phosphate synthase activity
E5259_RS11760	COG0135	phosphoribosylanthranilate isomerase activity
E5259_RS11770	COG0159	tryptophan synthase activity
E5259_RS11775	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E5259_RS11785	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
E5259_RS11790	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
E5259_RS11800	COG1737	Transcriptional regulator
E5259_RS11805	COG2081	HI0933 family
E5259_RS11810	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
E5259_RS11815	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
E5259_RS11820	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
E5259_RS11820	COG0539	negative regulation of cytoplasmic translation
E5259_RS11835	COG4656	Part of a membrane complex involved in electron transport
E5259_RS11840	COG4658	electron transport chain
E5259_RS11845	COG4659	FMN binding
E5259_RS11850	COG4660	Part of a membrane complex involved in electron transport
E5259_RS11855	COG4657	Part of a membrane complex involved in electron transport
E5259_RS11860	COG1245	4Fe-4S binding domain
E5259_RS11860	COG2878	Part of a membrane complex involved in electron transport
E5259_RS11880	COG0632	four-way junction helicase activity
E5259_RS11885	COG2255	four-way junction helicase activity
E5259_RS11895	COG0826	peptidase U32
E5259_RS11905	COG0768	penicillin binding
E5259_RS11910	COG1051	belongs to the nudix hydrolase family
E5259_RS11935	COG0227	Belongs to the bacterial ribosomal protein bL28 family
E5259_RS11945	COG1461	Dihydroxyacetone kinase
E5259_RS11950	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E5259_RS11970	COG1803	Methylglyoxal synthase
E5259_RS11975	COG0742	ribosomal rna small subunit methyltransferase
E5259_RS11980	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
E5259_RS11990	COG3314	Sporulation integral membrane protein YlbJ
E5259_RS11995	COG2195	Cleaves the N-terminal amino acid of tripeptides
E5259_RS12000	COG0739	heme binding
E5259_RS12005	COG2357	RelA SpoT domain protein
E5259_RS12010	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E5259_RS12010	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
E5259_RS12015	COG1187	pseudouridine synthase activity
E5259_RS12030	COG4221	oxidoreductase activity
E5259_RS12040	COG0564	pseudouridine synthase activity
E5259_RS12045	COG0681	Belongs to the peptidase S26 family
E5259_RS12050	COG3331	DNA recombination
E5259_RS12055	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
E5259_RS12080	COG1028	Short-chain dehydrogenase reductase Sdr
E5259_RS12095	COG2205	protein histidine kinase activity
E5259_RS12100	COG1136	(ABC) transporter
E5259_RS12105	COG0577	efflux transmembrane transporter activity
E5259_RS12135	COG4819	ethanolamine utilization protein
E5259_RS12140	COG4303	Ethanolamine ammonia lyase large subunit
E5259_RS12145	COG4302	ethanolamine ammonia-lyase activity
E5259_RS12155	COG1012	belongs to the aldehyde dehydrogenase family
E5259_RS12155	COG1454	alcohol dehydrogenase
E5259_RS12170	COG4869	propanediol catabolic process
E5259_RS12180	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
E5259_RS12185	COG3192	ethanolamine utilization protein
E5259_RS12195	COG0719	Fe-S assembly protein
E5259_RS12200	COG1309	transcriptional regulator
E5259_RS12230	COG0534	Mate efflux family protein
E5259_RS12235	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E5259_RS12240	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E5259_RS12265	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E5259_RS12275	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
E5259_RS12275	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E5259_RS12290	COG1802	Transcriptional regulator
E5259_RS12310	COG2207	Transcriptional regulator
E5259_RS12315	COG1874	Beta-galactosidase
E5259_RS12325	COG2205	protein histidine kinase activity
E5259_RS12330	COG0789	Transcriptional regulator
E5259_RS12350	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E5259_RS12355	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E5259_RS12375	COG0737	Belongs to the 5'-nucleotidase family
E5259_RS12385	COG0745	RESPONSE REGULATOR receiver
E5259_RS12390	COG5002	protein histidine kinase activity
E5259_RS12415	COG0745	RESPONSE REGULATOR receiver
E5259_RS12420	COG2205	protein histidine kinase activity
E5259_RS12435	COG1136	(ABC) transporter
E5259_RS12445	COG1131	(ABC) transporter
E5259_RS12455	COG1396	sequence-specific DNA binding
E5259_RS12460	COG1733	regulation of RNA biosynthetic process
E5259_RS12470	COG4977	sequence-specific DNA binding
E5259_RS12480	COG0789	Transcriptional regulator
E5259_RS12490	COG0242	peptide deformylase activity
E5259_RS12535	COG1357	PFAM Pentapeptide repeats (8 copies)
E5259_RS12550	COG0534	Mate efflux family protein
E5259_RS12555	COG0488	(ABC) transporter
E5259_RS12560	COG0110	maltose O-acetyltransferase activity
E5259_RS12575	COG1151	hydroxylamine reductase activity
E5259_RS12580	COG1116	anion transmembrane transporter activity
E5259_RS12580	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E5259_RS12585	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E5259_RS12590	COG1116	anion transmembrane transporter activity
E5259_RS12615	COG2226	methyltransferase
E5259_RS12640	COG1733	regulation of RNA biosynthetic process
E5259_RS12655	COG1530	ribonuclease E activity
E5259_RS12660	COG1051	belongs to the nudix hydrolase family
E5259_RS12670	COG0261	This protein binds to 23S rRNA in the presence of protein L20
E5259_RS12680	COG0211	Belongs to the bacterial ribosomal protein bL27 family
E5259_RS12685	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
E5259_RS12690	COG1534	Rna-binding protein
E5259_RS12695	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
E5259_RS12700	COG1713	HD superfamily hydrolase involved in NAD metabolism
E5259_RS12705	COG0799	negative regulation of ribosome biogenesis
E5259_RS12710	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E5259_RS12725	COG1609	Transcriptional regulator
E5259_RS12730	COG1349	DNA-binding transcription factor activity
E5259_RS12740	COG0371	Dehydrogenase
E5259_RS12760	COG1131	(ABC) transporter
E5259_RS12795	COG1686	Belongs to the peptidase S11 family
E5259_RS12800	COG0488	(ABC) transporter
E5259_RS12810	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E5259_RS12830	COG0583	DNA-binding transcription factor activity
E5259_RS12840	COG2059	Chromate
E5259_RS12850	COG0745	RESPONSE REGULATOR receiver
E5259_RS12855	COG5002	protein histidine kinase activity
E5259_RS12860	COG1136	(ABC) transporter
E5259_RS12865	COG0577	efflux transmembrane transporter activity
E5259_RS12895	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
E5259_RS12905	COG2378	regulation of single-species biofilm formation
E5259_RS12935	COG2207	Transcriptional regulator
E5259_RS12965	COG2207	Transcriptional regulator
E5259_RS12965	COG1917	Cupin 2, conserved barrel domain protein
E5259_RS12970	COG0697	spore germination
E5259_RS12990	COG0038	chloride channel
E5259_RS12995	COG0745	RESPONSE REGULATOR receiver
E5259_RS13000	COG5002	protein histidine kinase activity
E5259_RS13005	COG0577	efflux transmembrane transporter activity
E5259_RS13005	COG1136	(ABC) transporter
E5259_RS13030	COG0642	Histidine kinase
E5259_RS13035	COG0745	RESPONSE REGULATOR receiver
E5259_RS13040	COG1971	Probably functions as a manganese efflux pump
E5259_RS13045	COG0667	Aldo Keto reductase
E5259_RS13050	COG5002	protein histidine kinase activity
E5259_RS13050	COG0642	Histidine kinase
E5259_RS13055	COG0745	RESPONSE REGULATOR receiver
E5259_RS13065	COG1733	regulation of RNA biosynthetic process
E5259_RS13110	COG0583	DNA-binding transcription factor activity
E5259_RS13115	COG2264	protein methyltransferase activity
E5259_RS13125	COG2205	protein histidine kinase activity
E5259_RS13130	COG0745	RESPONSE REGULATOR receiver
E5259_RS13155	COG1733	regulation of RNA biosynthetic process
E5259_RS13165	COG1201	RNA secondary structure unwinding
E5259_RS13175	COG0534	Mate efflux family protein
E5259_RS13185	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
E5259_RS13190	COG0577	efflux transmembrane transporter activity
E5259_RS13240	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E5259_RS13240	COG1199	ATP-dependent helicase activity
E5259_RS13250	COG0778	Nitroreductase
E5259_RS13255	COG1733	regulation of RNA biosynthetic process
E5259_RS13260	COG0745	RESPONSE REGULATOR receiver
E5259_RS13295	COG0745	RESPONSE REGULATOR receiver
E5259_RS13305	COG1136	(ABC) transporter
E5259_RS13315	COG2205	protein histidine kinase activity
E5259_RS13320	COG0745	RESPONSE REGULATOR receiver
E5259_RS13335	COG1136	(ABC) transporter
E5259_RS13345	COG0577	efflux transmembrane transporter activity
E5259_RS13345	COG1136	(ABC) transporter
E5259_RS13350	COG5002	protein histidine kinase activity
E5259_RS13355	COG0745	RESPONSE REGULATOR receiver
E5259_RS13365	COG2315	Protein conserved in bacteria
E5259_RS13480	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
E5259_RS13550	COG1136	(ABC) transporter
E5259_RS13555	COG5002	protein histidine kinase activity
E5259_RS13560	COG0745	RESPONSE REGULATOR receiver
E5259_RS13565	COG3708	Transcriptional regulator
E5259_RS13565	COG2207	Transcriptional regulator
E5259_RS13575	COG0395	ABC-type sugar transport system, permease component
E5259_RS13585	COG0745	RESPONSE REGULATOR receiver
E5259_RS13590	COG5002	protein histidine kinase activity
E5259_RS13600	COG1490	D-aminoacyl-tRNA deacylase activity
E5259_RS13605	COG0628	permease
E5259_RS13610	COG0037	tRNA processing
E5259_RS13620	COG0564	pseudouridine synthase activity
E5259_RS13630	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
E5259_RS13635	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
E5259_RS13645	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
E5259_RS13655	COG2155	Conserved Protein
E5259_RS13665	COG1686	Belongs to the peptidase S11 family
E5259_RS13670	COG1803	Methylglyoxal synthase
E5259_RS13680	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
E5259_RS13685	COG2894	cell division
E5259_RS13690	COG0768	penicillin binding
E5259_RS13715	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
E5259_RS13720	COG2081	HI0933 family
E5259_RS13725	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
E5259_RS13730	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
E5259_RS13740	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
E5259_RS13745	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E5259_RS13750	COG4224	UPF0291 protein
E5259_RS13755	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
E5259_RS13775	COG1702	phosphate starvation-inducible protein PhoH
E5259_RS13785	COG1131	(ABC) transporter
E5259_RS13795	COG3290	protein histidine kinase activity
E5259_RS13800	COG3279	Response regulator of the LytR AlgR family
E5259_RS13810	COG1408	metallophosphoesterase
E5259_RS13875	COG2176	DNA-directed DNA polymerase activity
E5259_RS13955	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E5259_RS13965	COG1011	Hydrolase
E5259_RS13975	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
E5259_RS14000	COG1674	ftsk spoiiie
E5259_RS14005	COG1968	undecaprenyl-diphosphatase activity
E5259_RS14010	COG0740	serine-type endopeptidase activity
E5259_RS14020	COG0217	transcriptional regulatory protein
E5259_RS14025	COG1253	flavin adenine dinucleotide binding
E5259_RS14035	COG2337	Toxic component of a toxin-antitoxin (TA) module
E5259_RS14040	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E5259_RS14045	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E5259_RS14045	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
E5259_RS14050	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
E5259_RS14055	COG0488	(ABC) transporter
E5259_RS14065	COG1131	(ABC) transporter
E5259_RS14075	COG1802	Transcriptional regulator
E5259_RS14080	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E5259_RS14085	COG1404	Belongs to the peptidase S8 family
E5259_RS14120	COG1546	Belongs to the CinA family
E5259_RS14120	COG1058	Belongs to the CinA family
E5259_RS14125	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E5259_RS14130	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E5259_RS14135	COG1758	RNA polymerase activity
E5259_RS14140	COG0194	GDP metabolic process
E5259_RS14145	COG2052	Domain of unknown function (DUF370)
E5259_RS14150	COG1561	YicC-like family, N-terminal region
E5259_RS14155	COG1293	RNA-binding protein homologous to eukaryotic snRNP
E5259_RS14175	COG2199	diguanylate cyclase activity
E5259_RS14195	COG2201	protein-glutamate methylesterase activity
E5259_RS14215	COG0495	leucyl-tRNA aminoacylation
E5259_RS14225	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E5259_RS14230	COG0287	Prephenate dehydrogenase
E5259_RS14235	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E5259_RS14245	COG4716	Myosin-crossreactive antigen
E5259_RS14260	COG0642	Histidine kinase
E5259_RS14265	COG0745	RESPONSE REGULATOR receiver
E5259_RS14270	COG2205	protein histidine kinase activity
E5259_RS14270	COG0784	Response regulator, receiver
E5259_RS14295	COG5001	Diguanylate cyclase
E5259_RS14295	COG3300	MHYT domain
E5259_RS14315	COG0426	domain, Protein
E5259_RS14315	COG1773	rubredoxin
E5259_RS14325	COG1136	(ABC) transporter
E5259_RS14325	COG0577	efflux transmembrane transporter activity
E5259_RS14330	COG5002	protein histidine kinase activity
E5259_RS14345	COG3706	GGDEF domain
E5259_RS14360	COG1309	transcriptional regulator
E5259_RS14370	COG1131	(ABC) transporter
E5259_RS14375	COG1131	(ABC) transporter
E5259_RS14405	COG1442	glycosyl transferase family 8
E5259_RS14435	COG1132	(ABC) transporter
E5259_RS14440	COG0789	Transcriptional regulator
E5259_RS14440	COG4978	Transcriptional regulator
E5259_RS14465	COG1132	(ABC) transporter
E5259_RS14475	COG1442	glycosyl transferase family 8
E5259_RS14510	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E5259_RS14510	COG0300	oxidoreductase activity
E5259_RS14510	COG3321	synthase
E5259_RS14510	COG4221	oxidoreductase activity
E5259_RS14515	COG4221	oxidoreductase activity
E5259_RS14515	COG3321	synthase
E5259_RS14515	COG0300	oxidoreductase activity
E5259_RS14515	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E5259_RS14520	COG4221	oxidoreductase activity
E5259_RS14520	COG3321	synthase
E5259_RS14520	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E5259_RS14520	COG0300	oxidoreductase activity
E5259_RS14530	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E5259_RS14530	COG3321	synthase
E5259_RS14530	COG4221	oxidoreductase activity
E5259_RS14530	COG1028	Short-chain dehydrogenase reductase Sdr
E5259_RS14540	COG3425	synthase
E5259_RS14550	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E5259_RS14555	COG2070	2-Nitropropane dioxygenase
E5259_RS14555	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
E5259_RS14590	COG1484	DNA-dependent DNA replication
E5259_RS14615	COG3279	Response regulator of the LytR AlgR family
E5259_RS14630	COG1309	transcriptional regulator
E5259_RS14640	COG2801	Transposase and inactivated derivatives
E5259_RS15095	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
E5259_RS15180	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
E5259_RS15185	COG0406	alpha-ribazole phosphatase activity
E5259_RS15190	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E5259_RS15190	COG0072	phenylalanine-tRNA ligase activity
E5259_RS15195	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
E5259_RS15205	COG2247	cell wall binding repeat
E5259_RS15205	COG2385	sporulation resulting in formation of a cellular spore
E5259_RS15245	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E5259_RS15260	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E5259_RS15285	COG2508	Transcriptional regulator
E5259_RS15290	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
E5259_RS15325	COG0066	3-isopropylmalate dehydratase activity
E5259_RS15330	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
E5259_RS15335	COG0583	DNA-binding transcription factor activity
E5259_RS15340	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
E5259_RS15370	COG4172	Belongs to the ABC transporter superfamily
E5259_RS15375	COG0747	negative chemotaxis
E5259_RS15380	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E5259_RS15385	COG4174	ABC transporter (Permease)
E5259_RS15395	COG0583	DNA-binding transcription factor activity
E5259_RS15405	COG3620	sequence-specific DNA binding
E5259_RS15415	COG1131	(ABC) transporter
E5259_RS15430	COG0355	proton-transporting ATP synthase activity, rotational mechanism
E5259_RS15435	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
E5259_RS15440	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
E5259_RS15445	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
E5259_RS15450	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
E5259_RS15465	COG0356	it plays a direct role in the translocation of protons across the membrane
E5259_RS15470	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
E5259_RS15475	COG0492	ferredoxin-NADP+ reductase activity
E5259_RS15480	COG3118	belongs to the thioredoxin family
E5259_RS15485	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E5259_RS15490	COG2755	lipolytic protein G-D-S-L family
E5259_RS15490	COG0657	acetylesterase activity
E5259_RS15495	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E5259_RS15565	COG2199	diguanylate cyclase activity
E5259_RS15565	COG2203	Gaf domain
E5259_RS15570	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
E5259_RS15585	COG1278	Cold shock
E5259_RS15600	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
E5259_RS15605	COG1882	Formate acetyltransferase
E5259_RS15610	COG0352	thiamine-phosphate diphosphorylase activity
E5259_RS15610	COG0351	phosphomethylpyrimidine kinase
E5259_RS15625	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
E5259_RS15630	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
E5259_RS15635	COG1393	Belongs to the ArsC family
E5259_RS15640	COG1882	Formate acetyltransferase
E5259_RS15645	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
E5259_RS15650	COG2508	Transcriptional regulator
E5259_RS15680	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E5259_RS15685	COG2135	peptidase activity
E5259_RS15695	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E5259_RS15720	COG3254	rhamnose metabolic process
E5259_RS15730	COG1132	(ABC) transporter
E5259_RS15735	COG1132	(ABC) transporter
E5259_RS15745	COG0583	DNA-binding transcription factor activity
E5259_RS15750	COG0443	Heat shock 70 kDa protein
E5259_RS15760	COG2508	Transcriptional regulator
E5259_RS15765	COG0564	pseudouridine synthase activity
E5259_RS15775	COG5001	Diguanylate cyclase
E5259_RS15785	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E5259_RS15820	COG1070	Carbohydrate kinase
E5259_RS15825	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E5259_RS15830	COG1070	Carbohydrate kinase
E5259_RS15840	COG3842	ATPase activity
E5259_RS15845	COG3842	ATPase activity
E5259_RS15850	COG0395	ABC-type sugar transport system, permease component
E5259_RS15860	COG1653	transport
E5259_RS15865	COG1349	DNA-binding transcription factor activity
E5259_RS15870	COG3588	fructose-bisphosphate aldolase
E5259_RS15875	COG1027	Aspartate ammonia-lyase
E5259_RS15880	COG0583	DNA-binding transcription factor activity
E5259_RS15925	COG2207	Transcriptional regulator
E5259_RS15930	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E5259_RS15945	COG0534	Mate efflux family protein
E5259_RS15955	COG0745	RESPONSE REGULATOR receiver
E5259_RS15960	COG2205	protein histidine kinase activity
E5259_RS15965	COG1136	(ABC) transporter
E5259_RS15975	COG0789	Transcriptional regulator
E5259_RS15985	COG1191	sigma factor activity
E5259_RS16050	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E5259_RS16055	COG1278	Cold shock
E5259_RS16070	COG0714	Associated with various cellular activities
E5259_RS16080	COG4129	membrane
E5259_RS16115	COG4974	Belongs to the 'phage' integrase family
E5259_RS16125	COG4948	Mandelate Racemase Muconate Lactonizing
E5259_RS16135	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
E5259_RS16165	COG2207	Transcriptional regulator
E5259_RS16175	COG1442	glycosyl transferase family 8
E5259_RS16175	COG1216	Glycosyl transferase, family 2
E5259_RS16210	COG0463	Glycosyl transferase, family 2
E5259_RS16260	COG0052	Belongs to the universal ribosomal protein uS2 family
E5259_RS16280	COG0515	serine threonine protein kinase
E5259_RS16290	COG1307	EDD domain protein, DegV family
E5259_RS16300	COG0577	efflux transmembrane transporter activity
E5259_RS16315	COG0745	RESPONSE REGULATOR receiver
E5259_RS16320	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E5259_RS16330	COG1175	transmembrane transport
E5259_RS16370	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
E5259_RS16375	COG0124	histidyl-tRNA synthetase
E5259_RS16385	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E5259_RS16390	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E5259_RS16395	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E5259_RS16405	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E5259_RS16410	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E5259_RS16410	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E5259_RS16435	COG4536	flavin adenine dinucleotide binding
E5259_RS16455	COG3250	beta-galactosidase activity
E5259_RS16460	COG2388	GCN5-related N-acetyl-transferase
E5259_RS16465	COG0534	Mate efflux family protein
E5259_RS16495	COG2816	NAD+ diphosphatase activity
E5259_RS16500	COG1136	(ABC) transporter
E5259_RS16510	COG5002	protein histidine kinase activity
E5259_RS16515	COG0745	RESPONSE REGULATOR receiver
E5259_RS16535	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E5259_RS16540	COG1012	belongs to the aldehyde dehydrogenase family
E5259_RS16550	COG0561	phosphatase activity
E5259_RS16555	COG0546	phosphoglycolate phosphatase activity
E5259_RS16565	COG0561	phosphatase activity
E5259_RS16575	COG1116	anion transmembrane transporter activity
E5259_RS16580	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E5259_RS16585	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E5259_RS16595	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E5259_RS16600	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E5259_RS16605	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E5259_RS16605	COG0493	'glutamate synthase
E5259_RS16610	COG0402	S-adenosylhomocysteine deaminase activity
E5259_RS16620	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
E5259_RS16630	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
E5259_RS16635	COG0534	Mate efflux family protein
E5259_RS16640	COG1309	transcriptional regulator
E5259_RS16645	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
E5259_RS16655	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
E5259_RS16665	COG3250	beta-galactosidase activity
E5259_RS16670	COG0395	ABC-type sugar transport system, permease component
E5259_RS16675	COG1175	transmembrane transport
E5259_RS16680	COG1653	transport
E5259_RS16695	COG1115	amino acid carrier protein
E5259_RS16725	COG1982	Orn Lys Arg decarboxylase major
E5259_RS16730	COG0205	6-phosphofructokinase activity
E5259_RS16740	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E5259_RS16745	COG4608	Belongs to the ABC transporter superfamily
E5259_RS16750	COG0444	Belongs to the ABC transporter superfamily
E5259_RS16755	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E5259_RS16760	COG0601	transmembrane transport
E5259_RS16765	COG0747	negative chemotaxis
E5259_RS16790	COG0493	'glutamate synthase
E5259_RS16795	COG2211	Major facilitator Superfamily
E5259_RS16810	COG2207	Transcriptional regulator
E5259_RS16815	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
E5259_RS16820	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
E5259_RS16825	COG1733	regulation of RNA biosynthetic process
E5259_RS16835	COG0488	(ABC) transporter
E5259_RS16855	COG0460	homoserine dehydrogenase
E5259_RS16875	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E5259_RS16930	COG3052	prosthetic group binding
E5259_RS16935	COG3404	Formiminotransferase-cyclodeaminase
E5259_RS16945	COG1228	amidohydrolase
E5259_RS16950	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
E5259_RS16955	COG1073	alpha beta
E5259_RS16965	COG1473	amidohydrolase
E5259_RS16985	COG0492	ferredoxin-NADP+ reductase activity
E5259_RS16995	COG2986	histidine ammonia-lyase
E5259_RS17000	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
E5259_RS17030	COG2986	histidine ammonia-lyase
E5259_RS17050	COG5598	trimethylamine methyltransferase
E5259_RS17055	COG0251	oxidation-reduction process
E5259_RS17070	COG1115	amino acid carrier protein
E5259_RS17085	COG1175	transmembrane transport
E5259_RS17090	COG1653	transport
E5259_RS17095	COG2207	Transcriptional regulator
E5259_RS17100	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
E5259_RS17125	COG2986	histidine ammonia-lyase
E5259_RS17145	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
E5259_RS17150	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
E5259_RS17160	COG1247	-acetyltransferase
E5259_RS17200	COG1309	transcriptional regulator
E5259_RS17210	COG3835	regulator
E5259_RS17215	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E5259_RS17240	COG1757	Na H antiporter
E5259_RS17245	COG2515	1-aminocyclopropane-1-carboxylate deaminase
E5259_RS17250	COG0251	oxidation-reduction process
E5259_RS17255	COG2964	Protein conserved in bacteria
E5259_RS17270	COG1473	amidohydrolase
E5259_RS17285	COG4399	Belongs to the UPF0754 family
E5259_RS17290	COG3681	Belongs to the UPF0597 family
E5259_RS17300	COG0484	heat shock protein binding
E5259_RS17310	COG2357	RelA SpoT domain protein
E5259_RS17320	COG0534	Mate efflux family protein
E5259_RS17350	COG1674	ftsk spoiiie
E5259_RS17400	COG0741	lytic transglycosylase activity
E5259_RS17400	COG0791	NLP P60 protein
E5259_RS17420	COG0745	RESPONSE REGULATOR receiver
E5259_RS17430	COG1136	(ABC) transporter
E5259_RS17460	COG1803	Methylglyoxal synthase
E5259_RS17465	COG1597	lipid kinase activity
E5259_RS17470	COG0584	glycerophosphoryl diester phosphodiesterase
E5259_RS17480	COG1216	Glycosyl transferase, family 2
E5259_RS17485	COG1194	a g-specific adenine glycosylase
E5259_RS17515	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
E5259_RS17565	COG1473	amidohydrolase
E5259_RS17570	COG1288	antiporter activity
E5259_RS17615	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
E5259_RS17625	COG0542	response to heat
E5259_RS17635	COG0151	Belongs to the GarS family
E5259_RS17640	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E5259_RS17645	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
E5259_RS17650	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
E5259_RS17680	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
E5259_RS17685	COG0167	dihydroorotate dehydrogenase activity
E5259_RS17695	COG0284	orotidine-5'-phosphate decarboxylase activity
E5259_RS17700	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E5259_RS17705	COG1278	Cold shock
E5259_RS17745	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
E5259_RS17755	COG1122	ATPase activity
E5259_RS17760	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E5259_RS17765	COG0218	Necessary for normal cell division and for the maintenance of normal septation
E5259_RS17770	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
E5259_RS17785	COG0544	peptidyl-prolyl cis-trans isomerase activity
E5259_RS17805	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
E5259_RS18070	COG0358	DNA primase activity
E5259_RS18115	COG3646	Phage regulatory protein
E5259_RS18115	COG3645	SOS response
E5259_RS18170	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E5259_RS18175	COG5426	von Willebrand factor, type A
E5259_RS18180	COG1757	Na H antiporter
E5259_RS18205	COG0330	HflC and HflK could
E5259_RS18225	COG1959	2 iron, 2 sulfur cluster binding
E5259_RS18260	COG0745	RESPONSE REGULATOR receiver
E5259_RS18280	COG2233	PERMEase
E5259_RS18285	COG1904	glucuronate isomerase
E5259_RS18305	COG1609	Transcriptional regulator
E5259_RS18310	COG2721	sulfolactate sulfo-lyase activity
E5259_RS18325	COG4894	glucomannan catabolic process
E5259_RS18330	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E5259_RS18345	COG1523	belongs to the glycosyl hydrolase 13 family
E5259_RS18370	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E5259_RS18375	COG1309	transcriptional regulator
E5259_RS18385	COG0756	dUTP diphosphatase activity
E5259_RS18390	COG0602	queuosine metabolic process
E5259_RS18395	COG1185	polyribonucleotide nucleotidyltransferase activity
E5259_RS18400	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
E5259_RS18405	COG0791	NLP P60 protein
E5259_RS18410	COG0704	Plays a role in the regulation of phosphate uptake
E5259_RS18415	COG0196	riboflavin kinase activity
E5259_RS18420	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
E5259_RS18425	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
E5259_RS18430	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
E5259_RS18435	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
E5259_RS18445	COG2740	Nucleic-acid-binding protein implicated in transcription termination
E5259_RS18450	COG0195	Participates in both transcription termination and antitermination
E5259_RS18465	COG0598	Magnesium transport protein CorA
E5259_RS18470	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
E5259_RS18475	COG0187	DNA topoisomerase II activity
E5259_RS18480	COG0561	phosphatase activity
E5259_RS18485	COG0671	phosphoesterase, PA-phosphatase related
E5259_RS18515	COG0534	Mate efflux family protein
E5259_RS18520	COG0613	PHP domain protein
E5259_RS18540	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
E5259_RS18550	COG4753	response regulator
E5259_RS18550	COG2207	Transcriptional regulator
E5259_RS18555	COG0395	ABC-type sugar transport system, permease component
E5259_RS18560	COG1175	transmembrane transport
E5259_RS18570	COG2972	Histidine kinase
E5259_RS18575	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E5259_RS18585	COG4667	esterase of the alpha-beta hydrolase superfamily
E5259_RS18625	COG0582	viral genome integration into host DNA
E5259_RS18655	COG0789	Transcriptional regulator
E5259_RS18660	COG5504	Zn-dependent protease
E5259_RS18670	COG0791	NLP P60 protein
E5259_RS18670	COG0741	lytic transglycosylase activity
E5259_RS18725	COG2946	Replication initiation factor
E5259_RS18770	COG0582	viral genome integration into host DNA
E5259_RS18790	COG4372	Transposase
E5259_RS18795	COG0534	Mate efflux family protein
E5259_RS18805	COG4372	Transposase
E5259_RS18820	COG1028	Short-chain dehydrogenase reductase Sdr
E5259_RS18830	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E5259_RS18845	COG2084	Dehydrogenase
E5259_RS18850	COG3958	Transketolase
E5259_RS18875	COG4667	esterase of the alpha-beta hydrolase superfamily
E5259_RS18885	COG3279	Response regulator of the LytR AlgR family
E5259_RS18905	COG0560	Phosphoserine phosphatase
E5259_RS18955	COG3279	Response regulator of the LytR AlgR family
E5259_RS18970	COG1131	(ABC) transporter
E5259_RS19005	COG1012	belongs to the aldehyde dehydrogenase family
E5259_RS19015	COG0784	Response regulator, receiver
E5259_RS19015	COG2198	Histidine kinase
E5259_RS19015	COG2205	protein histidine kinase activity
E5259_RS19030	COG1396	sequence-specific DNA binding
E5259_RS19035	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
E5259_RS19040	COG0366	Alpha amylase catalytic
E5259_RS19045	COG0395	ABC-type sugar transport system, permease component
E5259_RS19050	COG1175	transmembrane transport
E5259_RS19060	COG2972	Histidine kinase
E5259_RS19065	COG3279	Response regulator of the LytR AlgR family
E5259_RS19290	COG3118	belongs to the thioredoxin family
E5259_RS19315	COG3728	DNA packaging
E5259_RS19375	COG0358	DNA primase activity
E5259_RS19420	COG3645	SOS response
E5259_RS19420	COG3646	Phage regulatory protein
E5259_RS19445	COG3646	Phage regulatory protein
E5259_RS19445	COG3645	SOS response
E5259_RS19470	COG0534	Mate efflux family protein
E5259_RS19485	COG0617	tRNA 3'-terminal CCA addition
E5259_RS19490	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E5259_RS19495	COG1131	(ABC) transporter
E5259_RS19515	COG2205	protein histidine kinase activity
E5259_RS19545	COG0640	Transcriptional regulator
E5259_RS19580	COG3119	arylsulfatase activity
E5259_RS19585	COG0395	ABC-type sugar transport system, permease component
E5259_RS19590	COG1175	transmembrane transport
E5259_RS19600	COG4753	response regulator
E5259_RS19600	COG2207	Transcriptional regulator
E5259_RS19605	COG2972	Histidine kinase
E5259_RS19610	COG0641	radical SAM
E5259_RS19620	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E5259_RS19645	COG3842	ATPase activity
E5259_RS19650	COG1176	ABC-type spermidine putrescine transport system, permease component I
E5259_RS19655	COG1177	transmembrane transport
E5259_RS19660	COG0564	pseudouridine synthase activity
E5259_RS19695	COG1175	transmembrane transport
E5259_RS19705	COG0745	RESPONSE REGULATOR receiver
E5259_RS19710	COG2205	protein histidine kinase activity
E5259_RS19720	COG1854	S-ribosylhomocysteine lyase activity
E5259_RS19725	COG5002	protein histidine kinase activity
E5259_RS19725	COG5001	Diguanylate cyclase
E5259_RS19735	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E5259_RS19740	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
E5259_RS19740	COG3608	succinylglutamate desuccinylase aspartoacylase
E5259_RS19775	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E5259_RS19780	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E5259_RS19785	COG0549	Belongs to the carbamate kinase family
E5259_RS19800	COG1070	Carbohydrate kinase
E5259_RS19810	COG1063	alcohol dehydrogenase
E5259_RS19815	COG1063	alcohol dehydrogenase
E5259_RS19825	COG0395	ABC-type sugar transport system, permease component
E5259_RS19860	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E5259_RS19865	COG1253	flavin adenine dinucleotide binding
E5259_RS19875	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E5259_RS19885	COG0215	cysteine-tRNA ligase activity
E5259_RS19890	COG1045	serine acetyltransferase
E5259_RS19895	COG3706	GGDEF domain
E5259_RS19900	COG5001	Diguanylate cyclase
E5259_RS19900	COG4251	negative regulation of phosphorylation
E5259_RS19900	COG3706	GGDEF domain
E5259_RS19900	COG2203	Gaf domain
E5259_RS19905	COG2205	protein histidine kinase activity
E5259_RS19905	COG0784	Response regulator, receiver
E5259_RS19910	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E5259_RS19915	COG0488	(ABC) transporter
E5259_RS19930	COG1937	Protein conserved in bacteria
E5259_RS19960	COG1234	tRNA 3'-trailer cleavage
E5259_RS19980	COG1069	ribulokinase activity
E5259_RS19985	COG1609	Transcriptional regulator
E5259_RS20000	COG0494	nUDIX hydrolase
E5259_RS20050	COG1309	transcriptional regulator
E5259_RS20070	COG1120	ATPase activity
E5259_RS20075	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E5259_RS20080	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E5259_RS20110	COG0456	acetyltransferase
E5259_RS20130	COG4978	Transcriptional regulator
E5259_RS20130	COG0789	Transcriptional regulator
E5259_RS20150	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E5259_RS20170	COG0674	pyruvate-flavodoxin oxidoreductase activity
E5259_RS20170	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
E5259_RS20175	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E5259_RS20185	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E5259_RS20190	COG1414	Transcriptional regulator
E5259_RS20220	COG0601	transmembrane transport
E5259_RS20235	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E5259_RS20240	COG0601	transmembrane transport
E5259_RS20250	COG0165	Argininosuccinate lyase
E5259_RS20260	COG4608	Belongs to the ABC transporter superfamily
E5259_RS20265	COG0444	Belongs to the ABC transporter superfamily
E5259_RS20270	COG2207	Transcriptional regulator
E5259_RS20270	COG3708	Transcriptional regulator
E5259_RS20295	COG4753	response regulator
E5259_RS20295	COG2207	Transcriptional regulator
E5259_RS20300	COG2972	Histidine kinase
E5259_RS20315	COG0717	Belongs to the dCTP deaminase family
E5259_RS20320	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E5259_RS20360	COG2188	Transcriptional regulator
E5259_RS20365	COG3437	response regulator, receiver
E5259_RS20385	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E5259_RS20430	COG0583	DNA-binding transcription factor activity
E5259_RS20440	COG0444	Belongs to the ABC transporter superfamily
E5259_RS20450	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E5259_RS20455	COG0601	transmembrane transport
E5259_RS20460	COG3608	succinylglutamate desuccinylase aspartoacylase
E5259_RS20465	COG1073	alpha beta
E5259_RS20465	COG2226	methyltransferase
E5259_RS20470	COG0251	oxidation-reduction process
E5259_RS20495	COG0395	ABC-type sugar transport system, permease component
E5259_RS20500	COG1175	transmembrane transport
E5259_RS20505	COG1609	Transcriptional regulator
E5259_RS20510	COG1199	ATP-dependent helicase activity
E5259_RS20530	COG1937	Protein conserved in bacteria
E5259_RS20550	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E5259_RS20570	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E5259_RS20575	COG1408	metallophosphoesterase
E5259_RS20590	COG0708	Exodeoxyribonuclease III
E5259_RS20600	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
E5259_RS20620	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
E5259_RS20630	COG0733	neurotransmitter:sodium symporter activity
E5259_RS20635	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E5259_RS20640	COG1486	melibiose metabolic process
E5259_RS20645	COG3681	Belongs to the UPF0597 family
E5259_RS20650	COG1473	amidohydrolase
E5259_RS20655	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
E5259_RS20660	COG0395	ABC-type sugar transport system, permease component
E5259_RS20665	COG1175	transmembrane transport
E5259_RS20675	COG1609	Transcriptional regulator
E5259_RS20680	COG1063	alcohol dehydrogenase
E5259_RS20685	COG0138	bifunctional purine biosynthesis protein purh
E5259_RS20695	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
E5259_RS20720	COG0519	Catalyzes the synthesis of GMP from XMP
E5259_RS20740	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E5259_RS20740	COG0723	plastoquinol--plastocyanin reductase activity
E5259_RS20760	COG2315	Protein conserved in bacteria
E5259_RS20765	COG0028	Belongs to the TPP enzyme family
E5259_RS20770	COG0440	acetolactate synthase activity
E5259_RS20810	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E5259_RS20820	COG0037	tRNA processing
E5259_RS20845	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
E5259_RS20855	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E5259_RS20865	COG0617	tRNA 3'-terminal CCA addition
E5259_RS20870	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E5259_RS20885	COG0698	ribose 5-phosphate isomerase
E5259_RS20890	COG0009	L-threonylcarbamoyladenylate synthase
E5259_RS20895	COG0860	N-Acetylmuramoyl-L-alanine amidase
E5259_RS20900	COG5001	Diguanylate cyclase
E5259_RS20920	COG4862	establishment of competence for transformation
E5259_RS20930	COG2221	Nitrite and sulphite reductase 4Fe-4S
E5259_RS20940	COG1028	Short-chain dehydrogenase reductase Sdr
E5259_RS20960	COG1175	transmembrane transport
E5259_RS20965	COG1653	transport
E5259_RS20985	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E5259_RS20990	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E5259_RS20995	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
E5259_RS21000	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
E5259_RS21020	COG1328	CTP reductase activity
E5259_RS21020	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
E5259_RS21025	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E5259_RS21040	COG1725	Transcriptional regulator
E5259_RS21055	COG1136	(ABC) transporter
E5259_RS21060	COG2205	protein histidine kinase activity
E5259_RS21065	COG0745	RESPONSE REGULATOR receiver
E5259_RS21075	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E5259_RS21085	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
E5259_RS21090	COG2890	protein-(glutamine-N5) methyltransferase activity
E5259_RS21095	COG3872	metal-dependent enzyme
E5259_RS21100	COG0254	rRNA binding
E5259_RS21115	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
E5259_RS21120	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E5259_RS21125	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E5259_RS21135	COG1316	TRANSCRIPTIONal
E5259_RS21145	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
E5259_RS21150	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E5259_RS21160	COG3901	Regulator of nitric oxide reductase transcription
E5259_RS21160	COG0348	domain, Protein
E5259_RS21175	COG1063	alcohol dehydrogenase
E5259_RS21180	COG1940	carbohydrate kinase activity
E5259_RS21185	COG5001	Diguanylate cyclase
E5259_RS21185	COG3300	MHYT domain
E5259_RS21205	COG2205	protein histidine kinase activity
E5259_RS21205	COG5002	protein histidine kinase activity
E5259_RS21205	COG0784	Response regulator, receiver
E5259_RS21210	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E5259_RS21230	COG1028	Short-chain dehydrogenase reductase Sdr
E5259_RS21265	COG1205	dead DEAH box helicase
E5259_RS21265	COG1111	helicase
E5259_RS21280	COG0789	Transcriptional regulator
E5259_RS21280	COG4978	Transcriptional regulator
E5259_RS21285	COG1720	tRNA m6t6A37 methyltransferase activity
E5259_RS21290	COG4154	Belongs to the RbsD FucU family
E5259_RS21295	COG0235	Class ii aldolase
E5259_RS21300	COG1070	Carbohydrate kinase
E5259_RS21305	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
E5259_RS21315	COG0318	PFAM AMP-dependent synthetase and ligase
E5259_RS21320	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E5259_RS21330	COG3064	Membrane
E5259_RS21330	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
E5259_RS21330	COG1073	alpha beta
E5259_RS21340	COG1309	transcriptional regulator
E5259_RS21345	COG2226	methyltransferase
E5259_RS21350	COG2211	Major facilitator Superfamily
E5259_RS21355	COG3622	Belongs to the hyi family
E5259_RS21360	COG0673	inositol 2-dehydrogenase activity
E5259_RS21365	COG1609	Transcriptional regulator
E5259_RS21375	COG0673	inositol 2-dehydrogenase activity
E5259_RS21395	COG2207	Transcriptional regulator
E5259_RS21395	COG0662	Cupin 2, conserved barrel domain protein
E5259_RS21430	COG3279	Response regulator of the LytR AlgR family
E5259_RS21435	COG3275	phosphorelay sensor kinase activity
E5259_RS21440	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
E5259_RS21450	COG5002	protein histidine kinase activity
E5259_RS21455	COG0745	RESPONSE REGULATOR receiver
E5259_RS21480	COG1757	Na H antiporter
E5259_RS21495	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E5259_RS21495	COG2080	2 iron, 2 sulfur cluster binding
E5259_RS21505	COG1929	Belongs to the glycerate kinase type-1 family
E5259_RS21510	COG3835	regulator
E5259_RS21525	COG0640	Transcriptional regulator
E5259_RS21535	COG2207	Transcriptional regulator
E5259_RS21585	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
E5259_RS21625	COG0348	domain, Protein
E5259_RS21635	COG0745	RESPONSE REGULATOR receiver
E5259_RS21640	COG5002	protein histidine kinase activity
E5259_RS21665	COG4372	Transposase
E5259_RS21730	COG0662	Cupin 2, conserved barrel domain protein
E5259_RS21740	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
E5259_RS21755	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
E5259_RS21760	COG0745	RESPONSE REGULATOR receiver
E5259_RS21765	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
E5259_RS21775	COG1136	(ABC) transporter
E5259_RS21775	COG0577	efflux transmembrane transporter activity
E5259_RS21780	COG2205	protein histidine kinase activity
E5259_RS21790	COG0534	Mate efflux family protein
E5259_RS21795	COG0110	maltose O-acetyltransferase activity
E5259_RS21800	COG2207	Transcriptional regulator
E5259_RS21800	COG1917	Cupin 2, conserved barrel domain protein
E5259_RS21810	COG0513	Belongs to the DEAD box helicase family
E5259_RS21825	COG0534	Mate efflux family protein
E5259_RS21835	COG0210	DNA helicase
E5259_RS21915	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E5259_RS21965	COG0740	serine-type endopeptidase activity
E5259_RS21970	COG4695	Portal protein
E5259_RS22090	COG2226	methyltransferase
E5259_RS22125	COG1396	sequence-specific DNA binding
E5259_RS22130	COG1396	sequence-specific DNA binding
E5259_RS22170	COG1395	domain, Protein
E5259_RS22200	COG4496	protein, YerC YecD
E5259_RS22205	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
E5259_RS22210	COG1070	Carbohydrate kinase
E5259_RS22230	COG1242	4 iron, 4 sulfur cluster binding
E5259_RS22240	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E5259_RS22245	COG0726	polysaccharide deacetylase
E5259_RS22255	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E5259_RS22255	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
E5259_RS22275	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
E5259_RS22280	COG0733	neurotransmitter:sodium symporter activity
E5259_RS22290	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E5259_RS22305	COG0653	protein targeting
E5259_RS22310	COG0673	inositol 2-dehydrogenase activity
E5259_RS22350	COG2972	Histidine kinase
E5259_RS22355	COG2197	response regulator
E5259_RS22370	COG3064	Membrane
E5259_RS22430	COG1609	Transcriptional regulator
E5259_RS22435	COG0673	inositol 2-dehydrogenase activity
E5259_RS22440	COG1172	Belongs to the binding-protein-dependent transport system permease family
E5259_RS22445	COG1129	ABC transporter
E5259_RS22465	COG0673	inositol 2-dehydrogenase activity
E5259_RS22490	COG4555	ABC transporter
E5259_RS22495	COG4753	response regulator
E5259_RS22495	COG2207	Transcriptional regulator
E5259_RS22500	COG3250	beta-galactosidase activity
E5259_RS22510	COG0191	fructose-bisphosphate aldolase activity
E5259_RS22520	COG2169	Transcriptional regulator
E5259_RS22545	COG2986	histidine ammonia-lyase
E5259_RS22550	COG0583	DNA-binding transcription factor activity
E5259_RS22565	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
E5259_RS22575	COG1595	DNA-templated transcription, initiation
E5259_RS22600	COG0165	Argininosuccinate lyase
E5259_RS22605	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
E5259_RS22635	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
E5259_RS22635	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
E5259_RS22640	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
E5259_RS22645	COG1418	mRNA catabolic process
E5259_RS22650	COG0302	gtp cyclohydrolase
E5259_RS22655	COG0285	dihydrofolate synthase activity
E5259_RS22670	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
E5259_RS22675	COG3853	Toxic anion resistance protein (TelA)
E5259_RS22685	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E5259_RS22700	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
E5259_RS22705	COG0733	neurotransmitter:sodium symporter activity
E5259_RS22720	COG1079	Belongs to the binding-protein-dependent transport system permease family
E5259_RS22725	COG4603	Belongs to the binding-protein-dependent transport system permease family
E5259_RS22730	COG3845	ABC transporter
E5259_RS22735	COG1744	ABC transporter substrate-binding protein PnrA-like
E5259_RS22740	COG2267	carboxylic ester hydrolase activity
E5259_RS22755	COG1811	Na channel or pump
E5259_RS22760	COG3870	Protein conserved in bacteria
E5259_RS22775	COG1473	amidohydrolase
E5259_RS22785	COG1725	Transcriptional regulator
E5259_RS22790	COG1131	(ABC) transporter
E5259_RS22800	COG0393	Putative heavy-metal-binding
E5259_RS22805	COG1501	Belongs to the glycosyl hydrolase 31 family
E5259_RS22825	COG0395	ABC-type sugar transport system, permease component
E5259_RS22840	COG4753	response regulator
E5259_RS22840	COG2207	Transcriptional regulator
E5259_RS22855	COG0516	GMP reductase activity
E5259_RS22855	COG0517	IMP dehydrogenase activity
E5259_RS22865	COG0459	protein refolding
E5259_RS22870	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
E5259_RS22880	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E5259_RS22885	COG0758	DNA mediated transformation
E5259_RS22890	COG0606	chelatase, subunit chli
E5259_RS22900	COG2207	Transcriptional regulator
E5259_RS22915	COG0826	peptidase U32
E5259_RS22935	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
E5259_RS22950	COG4472	Bacterial protein of unknown function (DUF965)
E5259_RS22955	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E5259_RS22965	COG0301	tRNA thio-modification
E5259_RS22970	COG1104	cysteine desulfurase activity
E5259_RS22975	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E5259_RS22980	COG2264	protein methyltransferase activity
E5259_RS23005	COG0395	ABC-type sugar transport system, permease component
E5259_RS23010	COG1175	transmembrane transport
E5259_RS23045	COG1132	(ABC) transporter
E5259_RS23050	COG1132	(ABC) transporter
E5259_RS23060	COG0484	heat shock protein binding
E5259_RS23065	COG0443	Heat shock 70 kDa protein
E5259_RS23070	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
E5259_RS23075	COG1420	regulation of RNA biosynthetic process
E5259_RS23085	COG1595	DNA-templated transcription, initiation
E5259_RS23090	COG1757	Na H antiporter
E5259_RS23145	COG3534	alpha-L-arabinofuranosidase
E5259_RS23150	COG3507	Belongs to the glycosyl hydrolase 43 family
E5259_RS23155	COG0395	ABC-type sugar transport system, permease component
E5259_RS23160	COG1175	transmembrane transport
E5259_RS23170	COG1609	Transcriptional regulator
E5259_RS23185	COG1013	pyruvate-flavodoxin oxidoreductase activity
E5259_RS23195	COG2033	superoxide reductase activity
E5259_RS23215	COG2205	protein histidine kinase activity
E5259_RS23215	COG5002	protein histidine kinase activity
E5259_RS23215	COG0784	Response regulator, receiver
E5259_RS23225	COG1082	Xylose isomerase domain protein TIM barrel
E5259_RS23230	COG0673	inositol 2-dehydrogenase activity
E5259_RS23245	COG2169	Transcriptional regulator
E5259_RS23250	COG0235	Class ii aldolase
E5259_RS23255	COG4806	L-rhamnose isomerase
E5259_RS23260	COG1070	Carbohydrate kinase
E5259_RS23270	COG3437	response regulator, receiver
E5259_RS23285	COG2177	Part of the ABC transporter FtsEX involved in
E5259_RS23290	COG2884	Cell division ATP-binding protein ftsE
E5259_RS23295	COG3835	regulator
E5259_RS23300	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
E5259_RS23310	COG1073	alpha beta
E5259_RS23315	COG0714	Associated with various cellular activities
E5259_RS23330	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E5259_RS23355	COG0840	transmembrane signaling receptor activity
E5259_RS23400	COG4804	nuclease activity
E5259_RS23410	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E5259_RS23435	COG1597	lipid kinase activity
E5259_RS23440	COG0203	ribosomal protein L17
E5259_RS23445	COG0202	RNA polymerase activity
E5259_RS23450	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
E5259_RS23455	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
E5259_RS23460	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
E5259_RS23465	COG0257	Belongs to the bacterial ribosomal protein bL36 family
E5259_RS23470	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
E5259_RS23485	COG0563	adenylate kinase activity
E5259_RS23495	COG0200	Binds to the 23S rRNA
E5259_RS23505	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
E5259_RS23515	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
E5259_RS23520	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
E5259_RS23525	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
E5259_RS23545	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
E5259_RS23550	COG0255	Belongs to the universal ribosomal protein uL29 family
E5259_RS23555	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
E5259_RS23565	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
E5259_RS23575	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
E5259_RS23590	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
E5259_RS23595	COG0051	transcription antitermination factor activity, RNA binding
E5259_RS23600	COG0281	malic enzyme
E5259_RS23605	COG0039	L-malate dehydrogenase activity
E5259_RS23620	COG1362	aminopeptidase activity
E5259_RS23625	COG0383	alpha-mannosidase activity
E5259_RS23630	COG0395	ABC-type sugar transport system, permease component
E5259_RS23635	COG1175	transmembrane transport
E5259_RS23640	COG1653	transport
E5259_RS23655	COG2972	Histidine kinase
E5259_RS23690	COG2160	L-arabinose isomerase activity
E5259_RS23700	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E5259_RS23705	COG1481	regulation of sporulation
E5259_RS23715	COG0812	UDP-N-acetylmuramate dehydrogenase activity
E5259_RS23720	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
E5259_RS23740	COG2357	RelA SpoT domain protein
E5259_RS23745	COG3250	beta-galactosidase activity
E5259_RS23755	COG1653	transport
E5259_RS23760	COG0395	ABC-type sugar transport system, permease component
E5259_RS23765	COG4209	transmembrane transport
E5259_RS23785	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E5259_RS23795	COG1486	melibiose metabolic process
E5259_RS23800	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E5259_RS23805	COG0395	ABC-type sugar transport system, permease component
E5259_RS23810	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
E5259_RS23815	COG4209	transmembrane transport
E5259_RS23825	COG1796	DNA polymerase
E5259_RS23825	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
E5259_RS23840	COG2972	Histidine kinase
E5259_RS23845	COG2207	Transcriptional regulator
E5259_RS23855	COG2207	Transcriptional regulator
E5259_RS23855	COG4753	response regulator
E5259_RS23860	COG2972	Histidine kinase
E5259_RS23890	COG2378	regulation of single-species biofilm formation
E5259_RS23950	COG2340	Cysteine-rich secretory protein family
E5259_RS23965	COG1983	PspC domain protein
E5259_RS23990	COG1132	(ABC) transporter
E5259_RS24000	COG2972	Histidine kinase
E5259_RS24020	COG0444	Belongs to the ABC transporter superfamily
E5259_RS24025	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E5259_RS24030	COG0601	transmembrane transport
E5259_RS24040	COG2169	Transcriptional regulator
E5259_RS24045	COG1115	amino acid carrier protein
E5259_RS24050	COG1074	ATP-dependent DNA helicase activity
E5259_RS24055	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
E5259_RS24060	COG0561	phosphatase activity
E5259_RS24080	COG1175	transmembrane transport
E5259_RS24090	COG4753	response regulator
E5259_RS24090	COG2207	Transcriptional regulator
E5259_RS24095	COG2972	Histidine kinase
E5259_RS24105	COG0129	dihydroxy-acid dehydratase activity
E5259_RS24110	COG3408	Glycogen debranching enzyme
E5259_RS24115	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
E5259_RS24120	COG0673	inositol 2-dehydrogenase activity
E5259_RS24140	COG1609	Transcriptional regulator
E5259_RS24170	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
E5259_RS24175	COG4106	trans-aconitate 2-methyltransferase activity
E5259_RS24195	COG3275	phosphorelay sensor kinase activity
E5259_RS24200	COG0395	ABC-type sugar transport system, permease component
E5259_RS24205	COG4209	transmembrane transport
E5259_RS24275	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
E5259_RS24275	COG0517	IMP dehydrogenase activity
E5259_RS24280	COG0110	maltose O-acetyltransferase activity
E5259_RS24290	COG0426	domain, Protein
E5259_RS24300	COG0791	NLP P60 protein
E5259_RS24305	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E5259_RS24320	COG3064	Membrane
E5259_RS24320	COG0437	4 iron, 4 sulfur cluster binding
E5259_RS24325	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
E5259_RS24340	COG0531	amino acid
E5259_RS24345	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
E5259_RS24365	COG0657	acetylesterase activity
E5259_RS24380	COG1362	aminopeptidase activity
E5259_RS24385	COG0531	amino acid
E5259_RS24390	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E5259_RS24390	COG2080	2 iron, 2 sulfur cluster binding
E5259_RS24410	COG0534	Mate efflux family protein
E5259_RS24420	COG1691	(AIR) carboxylase
E5259_RS24430	COG0534	Mate efflux family protein
E5259_RS24435	COG3534	alpha-L-arabinofuranosidase
E5259_RS24440	COG0395	ABC-type sugar transport system, permease component
E5259_RS24445	COG1175	transmembrane transport
E5259_RS24450	COG1653	transport
E5259_RS24465	COG3940	Belongs to the glycosyl hydrolase 43 family
E5259_RS24470	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
E5259_RS24485	COG1063	alcohol dehydrogenase
E5259_RS24490	COG0395	ABC-type sugar transport system, permease component
E5259_RS24495	COG1175	transmembrane transport
E5259_RS24505	COG2188	Transcriptional regulator
E5259_RS24510	COG1063	alcohol dehydrogenase
E5259_RS24525	COG1063	alcohol dehydrogenase
E5259_RS24530	COG0673	inositol 2-dehydrogenase activity
E5259_RS24535	COG1070	Carbohydrate kinase
E5259_RS24540	COG1486	melibiose metabolic process
E5259_RS24545	COG1349	DNA-binding transcription factor activity
E5259_RS24550	COG1349	DNA-binding transcription factor activity
E5259_RS24560	COG2188	Transcriptional regulator
E5259_RS24570	COG2140	Oxalate decarboxylase
E5259_RS24580	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E5259_RS24605	COG0179	Fumarylacetoacetate (FAA) hydrolase
E5259_RS24610	COG1522	sequence-specific DNA binding
E5259_RS24620	COG1994	Peptidase M50
E5259_RS24630	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E5259_RS24675	COG4372	Transposase
E5259_RS24695	COG4974	Belongs to the 'phage' integrase family
E5259_RS24725	COG1511	domain protein
E5259_RS24750	COG1528	Iron-storage protein
E5259_RS24760	COG2855	membrane
E5259_RS24765	COG0583	DNA-binding transcription factor activity
E5259_RS24780	COG2207	Transcriptional regulator
E5259_RS24785	COG1312	Catalyzes the dehydration of D-mannonate
E5259_RS24790	COG0246	Mannitol dehydrogenase
E5259_RS24805	COG3300	MHYT domain
E5259_RS24805	COG5001	Diguanylate cyclase
E5259_RS24810	COG0789	Transcriptional regulator
E5259_RS24820	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E5259_RS24845	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E5259_RS24860	COG0656	L-ascorbic acid biosynthetic process
E5259_RS24865	COG1063	alcohol dehydrogenase
E5259_RS25005	COG0740	serine-type endopeptidase activity
E5259_RS25085	COG0328	RNA-DNA hybrid ribonuclease activity
E5259_RS25090	COG0629	single-stranded DNA binding
E5259_RS25150	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E5259_RS25180	COG2801	Transposase and inactivated derivatives
E5259_RS25195	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
E5259_RS25200	COG1053	succinate dehydrogenase
E5259_RS25230	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
E5259_RS25245	COG0039	L-malate dehydrogenase activity
E5259_RS25250	COG2205	protein histidine kinase activity
E5259_RS25255	COG0745	RESPONSE REGULATOR receiver
E5259_RS25280	COG4372	Transposase
E5259_RS25315	COG2946	Replication initiation factor
E5259_RS25380	COG0366	Alpha amylase catalytic
E5259_RS25385	COG0395	ABC-type sugar transport system, permease component
E5259_RS25390	COG1175	transmembrane transport
E5259_RS25400	COG1609	Transcriptional regulator
E5259_RS25430	COG3958	Transketolase
E5259_RS25435	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E5259_RS25445	COG1609	Transcriptional regulator
E5259_RS25450	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
E5259_RS25455	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
E5259_RS25460	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
E5259_RS25465	COG0205	6-phosphofructokinase activity
E5259_RS25480	COG0586	Pfam SNARE associated Golgi protein
E5259_RS25485	COG0646	methionine synthase
E5259_RS25485	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
E5259_RS25490	COG0590	tRNA wobble adenosine to inosine editing
E5259_RS25770	COG0358	DNA primase activity
E5259_RS25800	COG0629	single-stranded DNA binding
E5259_RS25850	COG0202	RNA polymerase activity
E5259_RS25915	COG3646	Phage regulatory protein
E5259_RS25915	COG3645	SOS response
E5259_RS25965	COG0582	viral genome integration into host DNA
E5259_RS26030	COG0791	NLP P60 protein
E5259_RS26045	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E5259_RS26045	COG0551	DNA topoisomerase type I activity
E5259_RS26060	COG0515	serine threonine protein kinase
E5259_RS26070	COG3843	relaxase mobilization nuclease domain protein
E5259_RS26080	COG0582	viral genome integration into host DNA
E5259_RS26150	COG1609	Transcriptional regulator
E5259_RS26155	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E5259_RS26155	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
E5259_RS26175	COG2508	Transcriptional regulator
E5259_RS26180	COG2088	sporulation resulting in formation of a cellular spore
E5259_RS26185	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
E5259_RS26190	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
E5259_RS26195	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E5259_RS26215	COG2207	Transcriptional regulator
E5259_RS26215	COG4753	response regulator
E5259_RS26225	COG0395	ABC-type sugar transport system, permease component
E5259_RS26240	COG4717	serine-type aminopeptidase activity
E5259_RS26245	COG0420	3'-5' exonuclease activity
E5259_RS26250	COG0017	Asparaginyl-tRNA synthetase
E5259_RS26275	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
E5259_RS26305	COG0768	penicillin binding
E5259_RS26310	COG0544	peptidyl-prolyl cis-trans isomerase activity
E5259_RS26325	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
E5259_RS26340	COG0697	spore germination
E5259_RS26345	COG1802	Transcriptional regulator
E5259_RS26350	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
E5259_RS26375	COG0534	Mate efflux family protein
E5259_RS26385	COG0534	Mate efflux family protein
E5259_RS26395	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
E5259_RS26400	COG1518	maintenance of DNA repeat elements
E5259_RS26435	COG3842	ATPase activity
E5259_RS26480	COG0438	transferase activity, transferring glycosyl groups
E5259_RS26485	COG0110	maltose O-acetyltransferase activity
E5259_RS26500	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E5259_RS26520	COG0582	viral genome integration into host DNA
E5259_RS26525	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E5259_RS26535	COG2207	Transcriptional regulator
E5259_RS26550	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E5259_RS26560	COG0116	Belongs to the methyltransferase superfamily
E5259_RS26560	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
E5259_RS26585	COG0252	asparaginase activity
E5259_RS26605	COG3250	beta-galactosidase activity
E5259_RS26610	COG0395	ABC-type sugar transport system, permease component
E5259_RS26615	COG1175	transmembrane transport
E5259_RS26630	COG2972	Histidine kinase
E5259_RS26635	COG2197	response regulator
E5259_RS26655	COG3426	butyrate kinase activity
E5259_RS26670	COG0657	acetylesterase activity
E5259_RS26685	COG1966	Carbon starvation protein
E5259_RS26700	COG1151	hydroxylamine reductase activity
E5259_RS26715	COG1509	lysine 2,3-aminomutase activity
E5259_RS26730	COG0789	Transcriptional regulator
E5259_RS26740	COG0191	fructose-bisphosphate aldolase activity
E5259_RS26750	COG2186	Transcriptional regulator
E5259_RS26755	COG1028	Short-chain dehydrogenase reductase Sdr
E5259_RS26760	COG3958	Transketolase
E5259_RS26765	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E5259_RS26775	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
E5259_RS26780	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E5259_RS26790	COG1595	DNA-templated transcription, initiation
E5259_RS26800	COG0577	efflux transmembrane transporter activity
E5259_RS26800	COG1136	(ABC) transporter
E5259_RS26810	COG0745	RESPONSE REGULATOR receiver
E5259_RS26820	COG3655	Transcriptional regulator
E5259_RS26860	COG1609	Transcriptional regulator
E5259_RS26875	COG0534	Mate efflux family protein
E5259_RS26880	COG1653	transport
E5259_RS26885	COG0395	ABC-type sugar transport system, permease component
E5259_RS26895	COG3250	beta-galactosidase activity
E5259_RS26900	COG1609	Transcriptional regulator
E5259_RS26905	COG2222	sugar isomerase
E5259_RS26910	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E5259_RS26920	COG2188	Transcriptional regulator
E5259_RS26940	COG1695	Transcriptional regulator
E5259_RS26945	COG1917	Cupin 2, conserved barrel domain protein
E5259_RS26945	COG2207	Transcriptional regulator
E5259_RS26950	COG0534	Mate efflux family protein
E5259_RS26955	COG0110	maltose O-acetyltransferase activity
E5259_RS26970	COG0395	ABC-type sugar transport system, permease component
E5259_RS26975	COG4209	transmembrane transport
E5259_RS26985	COG0745	RESPONSE REGULATOR receiver
E5259_RS26990	COG5002	protein histidine kinase activity
E5259_RS26995	COG0519	Catalyzes the synthesis of GMP from XMP
E5259_RS27020	COG1136	(ABC) transporter
E5259_RS27040	COG1136	(ABC) transporter
E5259_RS27040	COG0577	efflux transmembrane transporter activity
E5259_RS27045	COG5002	protein histidine kinase activity
E5259_RS27050	COG0745	RESPONSE REGULATOR receiver
E5259_RS27065	COG1193	negative regulation of DNA recombination
E5259_RS27090	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E5259_RS27095	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E5259_RS27100	COG0049	tRNA binding
E5259_RS27105	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
E5259_RS27110	COG1472	Belongs to the glycosyl hydrolase 3 family
E5259_RS27115	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
E5259_RS27120	COG0085	RNA polymerase activity
E5259_RS27140	COG1757	Na H antiporter
E5259_RS27145	COG3620	sequence-specific DNA binding
E5259_RS27200	COG0196	riboflavin kinase activity
E5259_RS27205	COG0531	amino acid
E5259_RS27210	COG1063	alcohol dehydrogenase
E5259_RS27240	COG0222	ribosome binding
E5259_RS27305	COG0395	ABC-type sugar transport system, permease component
E5259_RS27310	COG1175	transmembrane transport
E5259_RS27315	COG1653	transport
E5259_RS27330	COG2188	Transcriptional regulator
E5259_RS27345	COG5492	domain, Protein
E5259_RS27345	COG4932	domain protein
E5259_RS27435	COG2333	competence protein COMEC
E5259_RS27435	COG0658	competence protein
E5259_RS27445	COG1192	Involved in chromosome partitioning
E5259_RS27540	COG3858	chitin binding
E5259_RS27540	COG1388	LysM domain
E5259_RS27550	COG4974	Belongs to the 'phage' integrase family
E5259_RS27570	COG0081	regulation of translation
E5259_RS27580	COG0250	Participates in transcription elongation, termination and antitermination
E5259_RS27590	COG0267	Belongs to the bacterial ribosomal protein bL33 family
E5259_RS27595	COG0395	ABC-type sugar transport system, permease component
E5259_RS27605	COG1175	transmembrane transport
E5259_RS27645	COG1073	alpha beta
E5259_RS27650	COG2723	6-phospho-beta-galactosidase activity
E5259_RS27665	COG0673	inositol 2-dehydrogenase activity
E5259_RS27675	COG1175	transmembrane transport
E5259_RS27680	COG0395	ABC-type sugar transport system, permease component
E5259_RS27690	COG0346	lactoylglutathione lyase activity
E5259_RS27695	COG2207	Transcriptional regulator
E5259_RS27695	COG3708	Transcriptional regulator
E5259_RS27700	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E5259_RS27705	COG4608	Belongs to the ABC transporter superfamily
E5259_RS27710	COG0444	Belongs to the ABC transporter superfamily
E5259_RS27720	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E5259_RS27725	COG0601	transmembrane transport
E5259_RS27730	COG0747	negative chemotaxis
E5259_RS27775	COG0577	efflux transmembrane transporter activity
E5259_RS27775	COG1136	(ABC) transporter
E5259_RS27780	COG2205	protein histidine kinase activity
E5259_RS27785	COG0745	RESPONSE REGULATOR receiver
E5259_RS27795	COG2207	Transcriptional regulator
E5259_RS27800	COG2205	protein histidine kinase activity
E5259_RS27815	COG0745	RESPONSE REGULATOR receiver
E5259_RS27820	COG2207	Transcriptional regulator
E5259_RS27835	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
E5259_RS27840	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E5259_RS27845	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E5259_RS27860	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
E5259_RS27860	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
E5259_RS27885	COG1136	(ABC) transporter
E5259_RS27890	COG2252	PERMEase
E5259_RS27895	COG2205	protein histidine kinase activity
E5259_RS27900	COG0745	RESPONSE REGULATOR receiver
E5259_RS27910	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E5259_RS27915	COG0569	domain protein
E5259_RS27920	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E5259_RS27935	COG0500	methyltransferase
E5259_RS27940	COG2996	Protein conserved in bacteria
E5259_RS27955	COG0166	Belongs to the GPI family
E5259_RS27960	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E5259_RS27965	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E5259_RS27975	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E5259_RS27985	COG1830	Aldolase
E5259_RS27995	COG1737	Transcriptional regulator
E5259_RS28000	COG2205	protein histidine kinase activity
E5259_RS28000	COG0784	Response regulator, receiver
E5259_RS28005	COG1876	peptidase activity
E5259_RS28010	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
E5259_RS28015	COG2002	toxin-antitoxin pair type II binding
E5259_RS28025	COG4750	Nucleotidyl transferase
E5259_RS28030	COG1213	nucleotidyl transferase
E5259_RS28040	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
E5259_RS28055	COG1486	melibiose metabolic process
E5259_RS28060	COG2207	Transcriptional regulator
E5259_RS28070	COG1063	alcohol dehydrogenase
E5259_RS28075	COG0673	inositol 2-dehydrogenase activity
E5259_RS28080	COG0395	ABC-type sugar transport system, permease component
E5259_RS28085	COG1175	transmembrane transport
E5259_RS28100	COG0561	phosphatase activity
E5259_RS28110	COG1486	melibiose metabolic process
E5259_RS28120	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
E5259_RS28150	COG2207	Transcriptional regulator
E5259_RS28150	COG1609	Transcriptional regulator
E5259_RS28185	COG1131	(ABC) transporter
E5259_RS28200	COG2207	Transcriptional regulator
E5259_RS28210	COG0395	ABC-type sugar transport system, permease component
E5259_RS28215	COG1175	transmembrane transport
E5259_RS28235	COG0395	ABC-type sugar transport system, permease component
E5259_RS28240	COG1175	transmembrane transport
E5259_RS28255	COG1940	carbohydrate kinase activity
E5259_RS28265	COG0673	inositol 2-dehydrogenase activity
E5259_RS28275	COG0366	Alpha amylase catalytic
E5259_RS28280	COG0395	ABC-type sugar transport system, permease component
E5259_RS28305	COG5012	cobalamin binding
E5259_RS28325	COG5012	cobalamin binding
E5259_RS28350	COG0110	maltose O-acetyltransferase activity
E5259_RS28355	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E5259_RS28385	COG1940	carbohydrate kinase activity
E5259_RS28390	COG1846	Transcriptional regulator
E5259_RS28390	COG1940	carbohydrate kinase activity
E5259_RS28395	COG0534	Mate efflux family protein
E5259_RS28445	COG1592	Rubrerythrin
E5259_RS28450	COG1592	Rubrerythrin
E5259_RS28450	COG1773	rubredoxin
E5259_RS28455	COG0735	belongs to the Fur family
E5259_RS28460	COG1737	Transcriptional regulator
E5259_RS28470	COG2731	YhcH YjgK YiaL family protein
E5259_RS28475	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E5259_RS28480	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E5259_RS28485	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
E5259_RS28490	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E5259_RS28495	COG1028	Short-chain dehydrogenase reductase Sdr
E5259_RS28500	COG1472	Belongs to the glycosyl hydrolase 3 family
E5259_RS28505	COG0395	ABC-type sugar transport system, permease component
E5259_RS28510	COG1175	transmembrane transport
E5259_RS28520	COG4753	response regulator
E5259_RS28520	COG2207	Transcriptional regulator
E5259_RS28525	COG2972	Histidine kinase
E5259_RS28540	COG0791	NLP P60 protein
E5259_RS28560	COG2873	o-acetylhomoserine
E5259_RS28570	COG0534	Mate efflux family protein
E5259_RS28815	COG3723	Recombinational DNA repair protein, rece pathway
E5259_RS28825	COG5377	YqaJ viral recombinase family
E5259_RS28870	COG1396	sequence-specific DNA binding
E5259_RS28885	COG4974	Belongs to the 'phage' integrase family
E5259_RS28955	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
E5259_RS28960	COG0187	DNA topoisomerase II activity
E5259_RS28965	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
E5259_RS28975	COG0592	DNA-directed DNA polymerase activity