locus-tag	class	description
HL650_RS00005	ENOG4107QZW	Altronate oxidoreductase
HL650_RS00010	ENOG4105CTX	dehydratase
HL650_RS00035	ENOG4108IXP	Carbohydrate diacid transcriptional activator CdaR
HL650_RS00040	ENOG4105BZW	Glycerate kinase
HL650_RS00080	ENOG4107RSS	Hydrogenase accessory protein HypB
HL650_RS00090	ENOG4105WMM	Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity)
HL650_RS00110	ENOG4105FTV	AraC Family Transcriptional Regulator
HL650_RS00115	ENOG4108JE9	extracellular solute-binding protein family 1
HL650_RS00130	ENOG4105CK5	oxidoreductase
HL650_RS00150	ENOG4105CK5	oxidoreductase
HL650_RS00155	ENOG4105QG4	Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity)
HL650_RS00160	ENOG4105CT4	transporter
HL650_RS00165	ENOG4105VUF	Transcriptional regulator
HL650_RS00175	ENOG4107Z3H	Transcriptional regulator, TetR family
HL650_RS00195	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
HL650_RS00200	ENOG4108IQE	Amp-dependent synthetase and ligase
HL650_RS00205	ENOG4105W4W	Transcriptional regulator
HL650_RS00210	ENOG4105EHF	Converts the aldose L-fucose into the corresponding ketose L-fuculose (By similarity)
HL650_RS00215	ENOG4105DET	Rhamnulokinase
HL650_RS00220	ENOG4105FB2	class II Aldolase
HL650_RS00225	ENOG4105NWF	RbsD or FucU transport
HL650_RS00230	ENOG4108R96	Methyltransferase, YaeB family
HL650_RS00235	ENOG4108Z5V	transcriptional regulator, merr family
HL650_RS00255	ENOG4105BZU	Histidine kinase
HL650_RS00275	ENOG4105CHR	reductase
HL650_RS00310	ENOG4105BZU	Histidine kinase
HL650_RS00315	ENOG41061DF	Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P (By similarity)
HL650_RS00320	ENOG4105CPQ	Dehydrogenase
HL650_RS00335	ENOG4105HEE	Binding Domain protein
HL650_RS00345	ENOG4107QN2	dihydrolipoyl dehydrogenase
HL650_RS00350	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
HL650_RS00360	ENOG4108KGH	TRANSCRIPTIONal
HL650_RS00370	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
HL650_RS00375	ENOG4105C0H	protease
HL650_RS00380	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
HL650_RS00390	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
HL650_RS00395	ENOG41082DI	50s ribosomal protein l31
HL650_RS00400	ENOG4105CBJ	Metal-dependent enzyme
HL650_RS00405	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
HL650_RS00410	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
HL650_RS00430	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
HL650_RS00470	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
HL650_RS00475	ENOG4105CJD	(Anaerobic) ribonucleoside-triphosphate reductase
HL650_RS00490	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
HL650_RS00495	ENOG4105C5V	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity)
HL650_RS00500	ENOG4105CAS	nag kinase
HL650_RS00505	ENOG4105C8Y	Acetylornithine aminotransferase
HL650_RS00530	ENOG4105CHR	reductase
HL650_RS00540	ENOG41084EF	Ferredoxin
HL650_RS00550	ENOG4108S6Z	Negative regulator of genetic competence
HL650_RS00575	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
HL650_RS00580	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
HL650_RS00585	ENOG4108YZG	isomerase
HL650_RS00595	ENOG4107YWA	deoxycytidylate deaminase
HL650_RS00600	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
HL650_RS00625	ENOG41082I2	s4 domain protein
HL650_RS00630	ENOG4105VYY	sporulation protein yabp
HL650_RS00650	ENOG4105D3U	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
HL650_RS00660	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
HL650_RS00675	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HL650_RS00690	ENOG4105EKQ	RNA-directed DNA polymerase
HL650_RS00710	ENOG41086D8	Transcriptional regulator
HL650_RS00740	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
HL650_RS00745	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
HL650_RS00755	ENOG4105BZU	Histidine kinase
HL650_RS00760	ENOG4108ZP8	Acetolactate synthase small subunit
HL650_RS00765	ENOG4105C7K	acetolactate synthase
HL650_RS00770	ENOG4105MSB	protein, conserved in bacteria
HL650_RS00775	ENOG4108RAC	Rubrerythrin
HL650_RS00810	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
HL650_RS00820	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
HL650_RS00835	ENOG4105DR4	Methyltransferase
HL650_RS00845	ENOG4105DC1	bifunctional purine biosynthesis protein purh
HL650_RS00850	ENOG4105CPQ	Dehydrogenase
HL650_RS00860	ENOG4108U3T	pfkb domain protein
HL650_RS00870	ENOG4105C8J	)-transporter
HL650_RS00880	ENOG4107AYK	membrAne
HL650_RS00910	ENOG4105CGK	Exodeoxyribonuclease III
HL650_RS00920	ENOG4105C3J	Cysteine desulfurase
HL650_RS00930	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
HL650_RS00950	ENOG4108UPS	Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity)
HL650_RS00960	ENOG4105VPX	protein, conserved in bacteria
HL650_RS00975	ENOG4105DVT	helicase
HL650_RS00985	ENOG4105KME	endoribonuclease L-psp
HL650_RS00990	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
HL650_RS00995	ENOG4108D32	Methyltransferase
HL650_RS01000	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
HL650_RS01005	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
HL650_RS01015	ENOG4105C3U	ABC transporter
HL650_RS01020	ENOG4108JQ7	(ABC) transporter
HL650_RS01025	ENOG4105DND	Transcriptional regulator
HL650_RS01035	ENOG4107QIK	phosphoribosylformylglycinamidine synthase
HL650_RS01045	ENOG4108IXP	Carbohydrate diacid transcriptional activator CdaR
HL650_RS01060	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
HL650_RS01075	ENOG4105XN3	extracellular solute-binding protein family 1
HL650_RS01080	ENOG4105C2F	Histidine kinase
HL650_RS01085	ENOG4107VQW	regulatoR
HL650_RS01125	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HL650_RS01150	ENOG4107258	Transcriptional regulator
HL650_RS01155	ENOG4105D82	Glutamate dehydrogenase
HL650_RS01165	ENOG4105P3U	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HL650_RS01170	ENOG4105DI2	Pyruvate flavodoxin ferredoxin oxidoreductase domain protein
HL650_RS01245	ENOG4105DQ5	transport system permease protein
HL650_RS01250	ENOG4105EHG	Permease protein
HL650_RS01255	ENOG4105E0A	ABC, transporter
HL650_RS01315	ENOG4105CMD	Transcriptional regulator, GntR family
HL650_RS01320	ENOG4105EF1	ribulokinase
HL650_RS01345	ENOG41086D8	Transcriptional regulator
HL650_RS01385	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
HL650_RS01390	ENOG4105C5H	ABC transporter
HL650_RS01395	ENOG4105D82	Glutamate dehydrogenase
HL650_RS01400	ENOG4105BZU	Histidine kinase
HL650_RS01405	ENOG4105BZU	Histidine kinase
HL650_RS01410	ENOG4105D7W	serine acetyltransferase
HL650_RS01415	ENOG4105C8N	cysteinyl-tRNA synthetase
HL650_RS01420	ENOG4105KEB	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
HL650_RS01425	ENOG4105C2N	RNA methyltransferase TrmH family group 3
HL650_RS01430	ENOG4105QIV	RNA polymerase
HL650_RS01435	ENOG4105C2F	Histidine kinase
HL650_RS01440	ENOG4105EQD	regulatoR
HL650_RS01455	ENOG4105C50	Binding-protein-dependent transport systems, inner membrane component
HL650_RS01470	ENOG4105F9U	Dehydrogenase
HL650_RS01500	ENOG41067QW	Transcriptional regulator
HL650_RS01600	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
HL650_RS01720	ENOG41073TP	transcriptional regulator
HL650_RS01725	ENOG4105DR6	Trap dicarboxylate transporter, dctp subunit
HL650_RS01730	ENOG4108K1J	Transporter DctQ
HL650_RS01735	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
HL650_RS01740	ENOG4108HHA	Transketolase
HL650_RS01745	ENOG4108IUS	Transketolase
HL650_RS01750	ENOG4106J7G	oxidoreductase
HL650_RS01755	ENOG4105C5I	Dehydrogenase
HL650_RS01760	ENOG4105C5B	carbamate kinase
HL650_RS01765	ENOG4105IW6	Carbamoyltransferase
HL650_RS01770	ENOG4107S4Y	M20 DapE family protein YgeY
HL650_RS01775	ENOG4107RCH	Diaminopropionate ammonia-lyase
HL650_RS01800	ENOG4105VFE	sira family
HL650_RS01805	ENOG4107P0T	Selenium-dependent molybdenum hydroxylase system protein, YqeB family
HL650_RS01810	ENOG4105MJ6	selenium-dependent hydroxylase accessory protein YqeC
HL650_RS01820	ENOG4105BZU	Histidine kinase
HL650_RS01825	ENOG4106762	Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity)
HL650_RS01835	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
HL650_RS01845	ENOG4105F0P	binding-protein-dependent transport systems inner membrane Component
HL650_RS01850	ENOG4105EB1	binding-protein-dependent transport systems inner membrane Component
HL650_RS01875	ENOG4105C31	Tryptophanyl-tRNA synthetase
HL650_RS01880	ENOG41090KN	UPF0303 protein
HL650_RS01890	ENOG4105EMS	pseudouridine synthase
HL650_RS01895	ENOG4105D38	putrescine abc transporter
HL650_RS01900	ENOG4105F38	ABC transporter, permease
HL650_RS01910	ENOG4105HHQ	6-phosphogluconolactonase (EC 3.1.1.31)
HL650_RS01930	ENOG4105EQD	regulatoR
HL650_RS01935	ENOG4105C2F	Histidine kinase
HL650_RS01945	ENOG4105DB9	Binding-protein-dependent transport systems inner membrane component
HL650_RS01950	ENOG4105F66	Binding-protein-dependent transport systems inner membrane component
HL650_RS01980	ENOG4105C4X	radical SAM domain protein
HL650_RS01985	ENOG4105C2F	Histidine kinase
HL650_RS01990	ENOG4108VAC	response regulator
HL650_RS01995	ENOG4105BZ7	extracellular solute-binding protein family 1
HL650_RS02000	ENOG4105E4X	binding-protein-dependent transport systems inner membrane Component
HL650_RS02005	ENOG4105DRS	transport system, permease
HL650_RS02010	ENOG4105CBG	Sulfatase
HL650_RS02045	ENOG4105NA0	Transcriptional regulator
HL650_RS02070	ENOG4105EB3	Histidine kinase
HL650_RS02085	ENOG4105DA5	(ABC) transporter
HL650_RS02090	ENOG4105C0H	protease
HL650_RS02100	ENOG4108V1U	phospholipid-binding protein
HL650_RS02155	ENOG4105C8Q	Methyl-accepting chemotaxis
HL650_RS02160	ENOG4105BZU	Histidine kinase
HL650_RS02165	ENOG4105CPN	adenine deaminase
HL650_RS02170	ENOG4105C26	Dehydrogenase
HL650_RS02175	ENOG4105DFD	Na H antiporter
HL650_RS02180	ENOG4107R4J	Chloride channel
HL650_RS02210	ENOG4105CF3	3-Hydroxyisobutyrate dehydrogenase
HL650_RS02225	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
HL650_RS02230	ENOG4107QW4	alcohol dehydrogenase
HL650_RS02235	ENOG4105CEM	UPF0597 protein
HL650_RS02245	ENOG4105F0P	binding-protein-dependent transport systems inner membrane Component
HL650_RS02250	ENOG4105DRS	transport system, permease
HL650_RS02260	ENOG4105C5I	Dehydrogenase
HL650_RS02300	ENOG4108NRW	Phospholipase, patatin family
HL650_RS02315	ENOG4105C2F	Histidine kinase
HL650_RS02330	ENOG4105DRW	binding-protein-dependent transport systems inner membrane Component
HL650_RS02335	ENOG4105EQD	regulatoR
HL650_RS02345	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
HL650_RS02365	ENOG4105DB7	PHP domain protein
HL650_RS02370	ENOG4107QJQ	Mate efflux family protein
HL650_RS02395	ENOG4105G9B	Transcriptional regulator
HL650_RS02425	ENOG4105F5V	trimethylamine methyltransferase
HL650_RS02460	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
HL650_RS02465	ENOG4105D06	uba thif-type nad fad binding protein
HL650_RS02470	ENOG4108KSA	LysR family transcriptional regulator
HL650_RS02485	ENOG4108IJ0	Aspartate ammonia-lyase
HL650_RS02490	ENOG4107QPD	alcohol dehydrogenase
HL650_RS02500	ENOG4108IJ0	Aspartate ammonia-lyase
HL650_RS02505	ENOG4105C6K	Malic enzyme
HL650_RS02515	ENOG4105WE2	aldehyde ferredoxin oxidoreductase
HL650_RS02520	ENOG4105C94	Transporter
HL650_RS02525	ENOG4108Z4U	Ferredoxin
HL650_RS02530	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
HL650_RS02535	ENOG4108WIQ	phosphoesterase PA-phosphatase related protein
HL650_RS02540	ENOG410667J	hydrolase
HL650_RS02545	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HL650_RS02550	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HL650_RS02555	ENOG4105D7N	magnesium and cobalt transport protein CorA
HL650_RS02570	ENOG4105CHV	Transcription elongation factor NusA
HL650_RS02575	ENOG4105VZN	Nucleic-acid-binding protein implicated in transcription termination
HL650_RS02585	ENOG4107EEM	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
HL650_RS02590	ENOG4105KG7	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
HL650_RS02595	ENOG4105SFS	phosphoesterase RecJ domain protein
HL650_RS02600	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
HL650_RS02605	ENOG4105DTN	riboflavin biosynthesis protein ribF
HL650_RS02610	ENOG4108UTW	Plays a role in the regulation of phosphate uptake
HL650_RS02615	ENOG4105K4H	Nlp p60 protein
HL650_RS02620	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
HL650_RS02625	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
HL650_RS02630	ENOG4108RDD	Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity)
HL650_RS02635	ENOG4108Z1K	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
HL650_RS02645	ENOG4108RZE	Tetr family transcriptional regulator
HL650_RS02680	ENOG4108ESZ	Glycogen debranching enzyme
HL650_RS02695	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
HL650_RS02715	ENOG4105CTX	dehydratase
HL650_RS02720	ENOG4105ETE	Transcriptional regulator (LacI family
HL650_RS02725	ENOG4105DR6	Trap dicarboxylate transporter, dctp subunit
HL650_RS02735	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
HL650_RS02740	ENOG4105D2H	Uronic isomerase
HL650_RS02745	ENOG4105C2W	permease
HL650_RS02770	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
HL650_RS02795	ENOG4105C6T	cysteine synthase
HL650_RS02805	ENOG4108ZF1	Transcriptional regulator, BadM Rrf2 family
HL650_RS02840	ENOG4107S6Z	Na H antiporter
HL650_RS02845	ENOG4105CT8	Phosphorylase
HL650_RS02855	ENOG4108C33	Resolvase
HL650_RS02890	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
HL650_RS02895	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
HL650_RS02900	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HL650_RS02915	ENOG4105EC0	Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity)
HL650_RS02990	ENOG4105DY9	regulatoR
HL650_RS03030	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
HL650_RS03045	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
HL650_RS03055	ENOG4105CM2	brancheD-chain amino acid aminotransferase
HL650_RS03060	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
HL650_RS03080	ENOG4105D95	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity)
HL650_RS03095	ENOG4105DKQ	ROK family
HL650_RS03145	ENOG4105VMP	Transcriptional regulator
HL650_RS03155	ENOG4108V15	phosphotransferase enzyme family
HL650_RS03165	ENOG4105D2X	ABC transporter substrate-binding protein
HL650_RS03195	ENOG4105II7	pyrroline-5-carboxylate reductase
HL650_RS03215	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
HL650_RS03230	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
HL650_RS03235	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
HL650_RS03240	ENOG4105MN5	HAD-superfamily hydrolase subfamily IA variant 3
HL650_RS03245	ENOG4108JJB	ABC transporter
HL650_RS03250	ENOG4108JJB	ABC transporter
HL650_RS03255	ENOG4105EK6	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity)
HL650_RS03265	ENOG4108IUJ	4-alpha-glucanotransferase
HL650_RS03285	ENOG4106TD9	Diguanylate cyclase
HL650_RS03290	ENOG4105VEQ	Cold shock protein
HL650_RS03300	ENOG4105SKN	orotidine 5''-phosphate decarboxylase
HL650_RS03310	ENOG4107RY0	Catalyzes the conversion of dihydroorotate to orotate (By similarity)
HL650_RS03315	ENOG4107T14	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
HL650_RS03345	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
HL650_RS03350	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
HL650_RS03355	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
HL650_RS03360	ENOG4107QNG	Phosphoribosylglycinamide synthetase
HL650_RS03370	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
HL650_RS03380	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
HL650_RS03415	ENOG4105E4C	Lytic transglycosylase catalytic
HL650_RS03440	ENOG4107RT5	aminobenzoyl-glutamate utilization protein B
HL650_RS03495	ENOG4108ZIA	glycerol-3-phosphate responsive antiterminator
HL650_RS03520	ENOG4105D4U	had-superfamily hydrolase, subfamily iia
HL650_RS03530	ENOG4105CEN	a g-specific adenine glycosylase
HL650_RS03535	ENOG4105K64	Glycosyl transferase, family 2
HL650_RS03540	ENOG4108W5M	transcriptional regulator
HL650_RS03585	ENOG4107QW4	alcohol dehydrogenase
HL650_RS03590	ENOG4105UQX	Mate efflux family protein
HL650_RS03595	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HL650_RS03620	ENOG4108QXE	glycerophosphoryl diester phosphodiesterase
HL650_RS03625	ENOG4105CBD	Diacylglycerol kinase
HL650_RS03630	ENOG4108Z5K	methylglyoxal synthase
HL650_RS03635	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
HL650_RS03640	ENOG4105UQX	Mate efflux family protein
HL650_RS03660	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HL650_RS03670	ENOG4105CEM	UPF0597 protein
HL650_RS03675	ENOG4106MP8	UPF0754 membrane protein
HL650_RS03690	ENOG4105WWK	YheO domain protein
HL650_RS03695	ENOG4105KME	endoribonuclease L-psp
HL650_RS03705	ENOG4107S6Z	Na H antiporter
HL650_RS03755	ENOG4108RZE	Tetr family transcriptional regulator
HL650_RS03760	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
HL650_RS03765	ENOG4107RBB	ABC transporter, permease
HL650_RS03785	ENOG4107Y3V	-acetyltransferase
HL650_RS03800	ENOG4108K6F	triphosphoribosyl-dephospho-CoA synthase
HL650_RS03805	ENOG4105DUA	(citrate (pro-3S)-lyase ligase
HL650_RS03825	ENOG4105C84	Histidine ammonia-lyase
HL650_RS03855	ENOG4108RBJ	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
HL650_RS03860	ENOG4108R6W	Transcriptional regulator, ARAC family
HL650_RS03865	ENOG4105XN3	extracellular solute-binding protein family 1
HL650_RS03870	ENOG4105DB9	Binding-protein-dependent transport systems inner membrane component
HL650_RS03885	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HL650_RS03900	ENOG4105DA5	(ABC) transporter
HL650_RS03905	ENOG4105C5H	ABC transporter
HL650_RS03940	ENOG4105F5V	trimethylamine methyltransferase
HL650_RS03960	ENOG4105C84	Histidine ammonia-lyase
HL650_RS03990	ENOG4105DG4	malate L-lactate dehydrogenase
HL650_RS03995	ENOG4105C84	Histidine ammonia-lyase
HL650_RS04000	ENOG41086D8	Transcriptional regulator
HL650_RS04020	ENOG4108V4B	ThiJ pfpI
HL650_RS04025	ENOG4105D29	Helix-turn-helix type 11 domain protein
HL650_RS04035	ENOG4105C3M	thioredoxin reductase
HL650_RS04050	ENOG4105CI2	imidazolone-5-propionate hydrolase
HL650_RS04055	ENOG4105CCS	Glutamate formiminotransferase
HL650_RS04060	ENOG410908R	Methenyltetrahydrofolate cyclohydrolase
HL650_RS04065	ENOG4105XGS	Covalent carrier of the coenzyme of citrate lyase (By similarity)
HL650_RS04075	ENOG4105CHY	citrate lyase, alpha
HL650_RS04140	ENOG4105D6E	homoserine dehydrogenase
HL650_RS04150	ENOG41080QX	K07048 phosphotriesterase-related protein
HL650_RS04155	ENOG4105C5H	ABC transporter
HL650_RS04165	ENOG4105KVH	Transcriptional regulator
HL650_RS04170	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
HL650_RS04175	ENOG4105C52	Atpase, p-type (Transporting), had superfamily, subfamily ic
HL650_RS04200	ENOG4105DEF	Extracellular solute-binding protein, family 5
HL650_RS04205	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
HL650_RS04210	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
HL650_RS04215	ENOG4105C3U	ABC transporter
HL650_RS04220	ENOG4108JQ7	(ABC) transporter
HL650_RS04235	ENOG4105CTQ	phosphohexokinase
HL650_RS04250	ENOG4105BZG	amino acid carrier protein
HL650_RS04260	ENOG4108JE9	extracellular solute-binding protein family 1
HL650_RS04265	ENOG4105E4X	binding-protein-dependent transport systems inner membrane Component
HL650_RS04270	ENOG4105DRS	transport system, permease
HL650_RS04285	ENOG4108I5U	Uridine phosphorylase
HL650_RS04290	ENOG4105KG3	cytidine deaminase
HL650_RS04300	ENOG4105EKD	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity)
HL650_RS04310	ENOG4105C3S	Mate efflux family protein
HL650_RS04315	ENOG4108JEB	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
HL650_RS04325	ENOG4105CK1	PTS System
HL650_RS04330	ENOG4105BZU	Histidine kinase
HL650_RS04340	ENOG4105D6T	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
HL650_RS04345	ENOG4105BZ8	glutamate synthase
HL650_RS04350	ENOG4105CX6	glutaminyL-tRNA synthetase
HL650_RS04355	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
HL650_RS04365	ENOG4105EUS	Binding-protein-dependent transport systems, inner membrane component
HL650_RS04370	ENOG4107Z6I	Thiamine biosynthesis protein
HL650_RS04385	ENOG4108X4Q	Hydrolase
HL650_RS04395	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
HL650_RS04400	ENOG410667J	hydrolase
HL650_RS04410	ENOG4105C26	Dehydrogenase
HL650_RS04415	ENOG4107R6G	Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity)
HL650_RS04445	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
HL650_RS04450	ENOG4105E09	nadh pyrophosphatase
HL650_RS04470	ENOG4105UQX	Mate efflux family protein
HL650_RS04475	ENOG410830R	acetyltransferase
HL650_RS04485	ENOG4108XXK	NUDIX hydrolase
HL650_RS04500	ENOG4108JU6	CBS domain protein
HL650_RS04525	ENOG4105C3D	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
HL650_RS04530	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
HL650_RS04545	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
HL650_RS04550	ENOG4105C5X	domain protein
HL650_RS04555	ENOG4105D4P	Coproporphyrinogen iii oxidase
HL650_RS04560	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
HL650_RS04565	ENOG4105CUT	histidyl-tRNA synthetase
HL650_RS04570	ENOG4105C9M	aspartyl-trna synthetase
HL650_RS04585	ENOG4105FKQ	transcriptional regulator
HL650_RS04605	ENOG4105D56	permease protein
HL650_RS04610	ENOG4105DRS	transport system, permease
HL650_RS04615	ENOG4108RVA	ribokinase
HL650_RS04620	ENOG4107QQR	Sporulation
HL650_RS04635	ENOG4107RBB	ABC transporter, permease
HL650_RS04645	ENOG4105EPR	degv family
HL650_RS04655	ENOG4105D9P	serine threonine protein kinase
HL650_RS04675	ENOG4105CE9	30S ribosomal protein S2
HL650_RS04680	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
HL650_RS04695	ENOG4105KVH	Transcriptional regulator
HL650_RS04710	ENOG41081BK	membrane protein-like protein
HL650_RS04720	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HL650_RS04730	ENOG4105KVH	Transcriptional regulator
HL650_RS04755	ENOG4108QEG	Membrane
HL650_RS04800	ENOG4108Z15	abc transporter atp-binding protein
HL650_RS04805	ENOG4106KKU	
HL650_RS04810	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
HL650_RS04830	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
HL650_RS04860	ENOG4105CCT	upf0313 protein
HL650_RS04890	ENOG4106Z5D	Glycoside Hydrolase Family 43
HL650_RS04905	ENOG4105VEQ	Cold shock protein
HL650_RS04930	ENOG4105ECQ	AraC Family Transcriptional Regulator
HL650_RS04960	ENOG4105EMN	RNA polymerase sigma factor
HL650_RS04970	ENOG4107SWG	transcriptional regulator MERR family
HL650_RS05015	ENOG4105UQX	Mate efflux family protein
HL650_RS05060	ENOG4108RDQ	ABC transporter
HL650_RS05120	ENOG4105C5Q	Transcriptional regulator
HL650_RS05125	ENOG4108IJ0	Aspartate ammonia-lyase
HL650_RS05130	ENOG4105WYW	fructose-bisphosphate aldolase
HL650_RS05145	ENOG4108SA1	esterase
HL650_RS05175	ENOG4105BZU	Histidine kinase
HL650_RS05185	ENOG4108YBP	pseudouridine synthase
HL650_RS05195	ENOG4105GZI	Transcriptional regulator
HL650_RS05205	ENOG4105BZ1	(ABC) transporter
HL650_RS05210	ENOG4105BZ1	(ABC) transporter
HL650_RS05240	ENOG4105D1H	recombination factor protein RarA
HL650_RS05255	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
HL650_RS05270	ENOG4108MUX	N-hydroxyarylamine O-acetyltransferase
HL650_RS05285	ENOG4107YHD	transcriptional regulator
HL650_RS05290	ENOG4105F1A	Pyruvate formate-lyase
HL650_RS05300	ENOG41080E8	Transcriptional regulator, Spx MgsR family
HL650_RS05305	ENOG4108UIN	ybak prolyl-trna synthetase associated region
HL650_RS05310	ENOG4105C5H	ABC transporter
HL650_RS05320	ENOG4108UV6	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
HL650_RS05325	ENOG4105MN5	HAD-superfamily hydrolase subfamily IA variant 3
HL650_RS05330	ENOG4105DWF	phosphomethylpyrimidine kinase
HL650_RS05335	ENOG4105C6N	Formate acetyltransferase
HL650_RS05340	ENOG4105F1A	Pyruvate formate-lyase
HL650_RS05355	ENOG4105VEQ	Cold shock protein
HL650_RS05360	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
HL650_RS05365	ENOG4105DND	Transcriptional regulator
HL650_RS05370	ENOG4105EAM	Na Pi-cotransporter
HL650_RS05390	ENOG4105M6F	mutator MutT protein
HL650_RS05415	ENOG4105BZU	Histidine kinase
HL650_RS05435	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HL650_RS05440	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
HL650_RS05450	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
HL650_RS05470	ENOG4105KJF	protein tyrosine phosphatase
HL650_RS05475	ENOG4105ID8	Transcriptional regulator, ARAC family
HL650_RS05485	ENOG4105EBR	Carboxylesterase
HL650_RS05490	ENOG4105CT4	transporter
HL650_RS05500	ENOG4108W63	CRP FNR family transcriptional regulator
HL650_RS05505	ENOG4105K63	Thioredoxin
HL650_RS05510	ENOG4105C3M	thioredoxin reductase
HL650_RS05520	ENOG4107RFS	it plays a direct role in the translocation of protons across the membrane (By similarity)
HL650_RS05540	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
HL650_RS05545	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
HL650_RS05550	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
HL650_RS05585	ENOG4107TXC	Transcriptional regulator
HL650_RS05600	ENOG4105CJ1	ABC, transporter
HL650_RS05615	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
HL650_RS05620	ENOG4105BZU	Histidine kinase
HL650_RS05675	ENOG4105F66	Binding-protein-dependent transport systems inner membrane component
HL650_RS05680	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
HL650_RS05715	ENOG4108UW5	maltose o-acetyltransferase
HL650_RS05735	ENOG4105BZV	Phosphoadenosine phosphosulfate reductase
HL650_RS05740	ENOG4105GTN	ParB Domain Protein Nuclease
HL650_RS05795	ENOG4105DA5	(ABC) transporter
HL650_RS05805	ENOG41067QW	Transcriptional regulator
HL650_RS05815	ENOG4105SKE	transcriptional Regulator LysR family
HL650_RS05825	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
HL650_RS05830	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
HL650_RS05835	ENOG4105DEF	Extracellular solute-binding protein, family 5
HL650_RS05855	ENOG4105CK0	Membrane bOund o-acyl transferase mboat family protein
HL650_RS05865	ENOG4108ZP8	Acetolactate synthase small subunit
HL650_RS05870	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
HL650_RS05875	ENOG4105DUM	transcriptional regulator, lysR family
HL650_RS05880	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
HL650_RS05885	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
HL650_RS05915	ENOG4105KAV	tspo and mbr like protein
HL650_RS05950	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
HL650_RS05975	ENOG4107QID	Threonine synthase
HL650_RS05995	ENOG4105ENN	converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity)
HL650_RS06000	ENOG4105IH7	synthase
HL650_RS06005	ENOG4105JFG	SpoIID LytB domain protein
HL650_RS06015	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
HL650_RS06020	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
HL650_RS06025	ENOG4107TB6	phosphoglycerate mutase
HL650_RS06030	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
HL650_RS06035	ENOG4106S9K	Transcriptional regulator
HL650_RS06040	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
HL650_RS06045	ENOG4105BZU	Histidine kinase
HL650_RS06055	ENOG4105EEX	Two component transcriptional regulator (Winged helix family
HL650_RS06195	ENOG4105DA5	(ABC) transporter
HL650_RS06285	ENOG4108NEV	two component transcriptional regulator, LytTR family
HL650_RS06290	ENOG4105CEQ	signal transduction histidine kinase regulating citrate malate metabolism
HL650_RS06380	ENOG4107Y5K	Resolvase
HL650_RS06495	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
HL650_RS06580	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
HL650_RS06670	ENOG4106050	phage regulatory protein, rha family
HL650_RS06690	ENOG4108ESE	uses NADH to detoxify nitric oxide (NO), protecting several 4Fe-4S NO-sensitive enzymes. Has at least 2 reductase partners, only one of which (NorW, flavorubredoxin reductase) has been identified. NO probably binds to the di-iron center
HL650_RS06700	ENOG4105D3R	alkyl hydroperoxide reductase
HL650_RS06710	ENOG4105BZU	Histidine kinase
HL650_RS06720	ENOG4105BZU	Histidine kinase
HL650_RS06745	ENOG4105C7W	Xanthine dehydrogenase
HL650_RS06760	ENOG4105C84	Histidine ammonia-lyase
HL650_RS06765	ENOG4105CCI	Myosin-Cross-Reactive Antigen
HL650_RS06785	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
HL650_RS06795	ENOG4105C8T	Leucyl-tRNA synthetase
HL650_RS06810	ENOG4105BZU	Histidine kinase
HL650_RS06815	ENOG4107YTP	response regulator receiver protein
HL650_RS06820	ENOG4105C8Q	Methyl-accepting chemotaxis
HL650_RS06825	ENOG4107PHP	CheC --inhibitor of MCP methylation
HL650_RS06830	ENOG4108Z4W	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity)
HL650_RS06835	ENOG4105BZU	Histidine kinase
HL650_RS06840	ENOG4105CBS	Chea signal transduction histidine kinase
HL650_RS06860	ENOG4105DSJ	YicC domain protein
HL650_RS06870	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
HL650_RS06875	ENOG4105YMY	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
HL650_RS06880	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
HL650_RS06885	ENOG4105BZQ	cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
HL650_RS06890	ENOG4105CEV	competence damage-inducible protein
HL650_RS06920	ENOG4105J8Z	peptidase S8 and S53, subtilisin, kexin, sedolisin
HL650_RS06925	ENOG4107SDT	Homocitrate synthase
HL650_RS06930	ENOG4105DRR	Transcriptional regulator, GntR family
HL650_RS06940	ENOG4108IG5	Transcriptional regulator
HL650_RS06945	ENOG4105CIG	ABC transporter
HL650_RS06955	ENOG4105C5H	ABC transporter
HL650_RS06960	ENOG4105FF6	Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity)
HL650_RS06965	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
HL650_RS06970	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
HL650_RS06975	ENOG4108YZM	Toxic component of a toxin-antitoxin (TA) module (By similarity)
HL650_RS06985	ENOG4105EKQ	RNA-directed DNA polymerase
HL650_RS06995	ENOG4105C37	(CBS) domain
HL650_RS07000	ENOG4105CDY	transcriptional regulatory protein
HL650_RS07005	ENOG4105CVQ	ATP-dependent Clp protease, proteolytic subunit
HL650_RS07010	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
HL650_RS07015	ENOG4105CNU	cell division protein FtsK
HL650_RS07025	ENOG4105CDJ	oxidoreductase FAD NAD(P)-binding domain protein
HL650_RS07040	ENOG4108UXA	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
HL650_RS07110	ENOG4105DE5	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
HL650_RS07135	ENOG4105EKQ	RNA-directed DNA polymerase
HL650_RS07170	ENOG4105ETE	Transcriptional regulator (LacI family
HL650_RS07180	ENOG4105F0P	binding-protein-dependent transport systems inner membrane Component
HL650_RS07185	ENOG4105DRS	transport system, permease
HL650_RS07190	ENOG4105CKB	glycosidase
HL650_RS07195	ENOG4105DFY	n-acylglucosamine 2-epimerase
HL650_RS07200	ENOG4105HY2	Glycosidase related protein
HL650_RS07220	ENOG4105DG6	mannose-6-phosphate isomerase
HL650_RS07225	ENOG4105D3P	Mannan endo-1,4-beta-mannosidase
HL650_RS07230	ENOG4107V2S	Transcriptional regulator
HL650_RS07235	ENOG4105EH2	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity)
HL650_RS07255	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HL650_RS07275	ENOG4105CPF	Cell wall formation (By similarity)
HL650_RS07280	ENOG4107RBI	VanW family
HL650_RS07310	ENOG4105BZU	Histidine kinase
HL650_RS07315	ENOG4105BZU	Histidine kinase
HL650_RS07335	ENOG4105CT4	transporter
HL650_RS07340	ENOG4105CNT	hydrolase family 2
HL650_RS07365	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HL650_RS07370	ENOG4105BZU	Histidine kinase
HL650_RS07375	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HL650_RS07385	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
HL650_RS07415	ENOG4107QPB	Beta-lactamase domain protein
HL650_RS07420	ENOG4107SKW	Inherit from COG: Alpha beta hydrolase
HL650_RS07435	ENOG4105DE5	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
HL650_RS07445	ENOG4105C9A	Phoh family
HL650_RS07470	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
HL650_RS07475	ENOG4105VPS	UPF0291 protein
HL650_RS07480	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
HL650_RS07485	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
HL650_RS07495	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
HL650_RS07500	ENOG4105CXI	aluminum resistance protein
HL650_RS07505	ENOG4105CBX	hi0933 family
HL650_RS07510	ENOG4105DZ0	fad dependent oxidoreductase
HL650_RS07515	ENOG4105W5Q	DNA repair protein (RadC
HL650_RS07535	ENOG4105CJN	penicillin-binding protein
HL650_RS07545	ENOG41083CN	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity)
HL650_RS07555	ENOG4108Z5K	methylglyoxal synthase
HL650_RS07560	ENOG4105DZ1	carboxypeptidase
HL650_RS07580	ENOG4105DFA	alanine racemase domain protein
HL650_RS07590	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
HL650_RS07605	ENOG4105C34	Pseudouridine synthase
HL650_RS07620	ENOG4105CB3	Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity)
HL650_RS07625	ENOG4105C02	permease
HL650_RS07630	ENOG4108YYA	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity)
HL650_RS07645	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
HL650_RS07655	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HL650_RS07675	ENOG4107QRT	dEAD DEAH box helicase
HL650_RS07690	ENOG4105BZU	Histidine kinase
HL650_RS07695	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HL650_RS07700	ENOG4105C5Q	Transcriptional regulator
HL650_RS07705	ENOG4108XEP	Alpha Beta Hydrolase Fold protein
HL650_RS07725	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HL650_RS07740	ENOG410631K	Membrane
HL650_RS07745	ENOG4106AXJ	AraC family transcriptional regulator
HL650_RS07760	ENOG4105DHT	Metal Dependent Phosphohydrolase
HL650_RS07780	ENOG4105C19	ABC transporter
HL650_RS07785	ENOG4105EWM	Histidine kinase
HL650_RS07790	ENOG4105CJZ	response regulator
HL650_RS07800	ENOG4105FGV	Chromate
HL650_RS07810	ENOG4107V2S	Transcriptional regulator
HL650_RS07815	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
HL650_RS07830	ENOG4105C5H	ABC transporter
HL650_RS07835	ENOG4105DZ1	carboxypeptidase
HL650_RS07870	ENOG4105DA5	(ABC) transporter
HL650_RS07875	ENOG4105BZU	Histidine kinase
HL650_RS07890	ENOG4108MDK	Dehydrogenase
HL650_RS07905	ENOG4105ETE	Transcriptional regulator (LacI family
HL650_RS07915	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
HL650_RS07920	ENOG4105KEM	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity)
HL650_RS07925	ENOG4108WF2	Metal Dependent Phosphohydrolase
HL650_RS07930	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
HL650_RS07935	ENOG410812S	Rna-binding protein
HL650_RS07940	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HL650_RS07945	ENOG4105K46	50S ribosomal protein l27
HL650_RS07965	ENOG4108Z4K	mutator MutT protein
HL650_RS07970	ENOG4105C03	ribonuclease
HL650_RS08010	ENOG4107QTR	Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity)
HL650_RS08045	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
HL650_RS08055	ENOG4105CJ1	ABC, transporter
HL650_RS08060	ENOG4108Z6Z	Transcriptional regulator
HL650_RS08110	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
HL650_RS08135	ENOG4105C6N	Formate acetyltransferase
HL650_RS08140	ENOG4105F1A	Pyruvate formate-lyase
HL650_RS08170	ENOG4105DIW	FeS assembly protein SUFB
HL650_RS08175	ENOG4105NDK	ethanolamine utilization protein
HL650_RS08180	ENOG4105ENY	Ethanolamine utilization protein eutH
HL650_RS08205	ENOG4105KNY	Microcompartments protein
HL650_RS08210	ENOG4105C0A	alcohol dehydrogenase
HL650_RS08215	ENOG4106D67	ethanolamine utilization protein
HL650_RS08220	ENOG4107FQ9	ethanolamine ammonia-lyase
HL650_RS08225	ENOG4105CPD	ethanolamine ammonia-lyase
HL650_RS08230	ENOG4105DYY	Reactivating factor for ethanolamine ammonia lyase
HL650_RS08235	ENOG4105KTW	ethanolamine utilization protein
HL650_RS08240	ENOG4105M3W	utilization protein
HL650_RS08265	ENOG4105C19	ABC transporter
HL650_RS08270	ENOG4105EWM	Histidine kinase
HL650_RS08280	ENOG41080XS	Cobyrinic acid ac-diamide synthase
HL650_RS08290	ENOG4105CN5	Metallo-Beta-Lactamase
HL650_RS08295	ENOG4108UI2	Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity)
HL650_RS08300	ENOG4105C3F	Signal peptidase i
HL650_RS08305	ENOG4105C34	Pseudouridine synthase
HL650_RS08315	ENOG4105EMU	Dehydrogenase
HL650_RS08325	ENOG4105EVE	HAD-superfamily hydrolase subfamily IA variant 3
HL650_RS08335	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
HL650_RS08345	ENOG4105FAA	peptidase M23
HL650_RS08350	ENOG4105CIN	aminoacyl-histidine dipeptidase
HL650_RS08360	ENOG4105H20	Sporulation integral membrane protein YlbJ
HL650_RS08370	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
HL650_RS08375	ENOG4106H78	methyltransferase
HL650_RS08380	ENOG4108Z5K	methylglyoxal synthase
HL650_RS08405	ENOG4105DP4	dak2 domain fusion protein ylov
HL650_RS08415	ENOG4105VB9	50S ribosomal protein l28
HL650_RS08435	ENOG4105CSR	polyphosphate kinase 2
HL650_RS08440	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
HL650_RS08445	ENOG4105CJN	penicillin-binding protein
HL650_RS08455	ENOG4105CFP	Peptidase U32
HL650_RS08465	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
HL650_RS08470	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
HL650_RS08485	ENOG4105CJ2	(LipO)protein
HL650_RS08490	ENOG4107SVV	electron transport complex, RnfABCDGE type, B subunit
HL650_RS08495	ENOG4105DGN	Electron transport complex
HL650_RS08500	ENOG4105DZB	Electron transport complex
HL650_RS08510	ENOG4105D6A	Electron transport complex
HL650_RS08515	ENOG4107QTR	Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity)
HL650_RS08530	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
HL650_RS08535	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
HL650_RS08540	ENOG4105CAT	Cytidine monophosphate kinase
HL650_RS08545	ENOG4105CBX	hi0933 family
HL650_RS08550	ENOG4106G6Q	Transcriptional regulator
HL650_RS08555	ENOG4107QSA	Oxaloacetate decarboxylase
HL650_RS08560	ENOG4105D9Q	decarboxylase (Beta subunit)
HL650_RS08565	ENOG4106063	Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit
HL650_RS08580	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
HL650_RS08590	ENOG4108ZGB	N-(5'-phosphoribosyl)anthranilate isomerase
HL650_RS08600	ENOG4105DDQ	anthranilate synthase
HL650_RS08625	ENOG4108IFG	nitrite reductase, (NAD(P)H)
HL650_RS08635	ENOG4105CJG	carbon-monoxide dehydrogenase catalytic subunit
HL650_RS08665	ENOG4105CF3	3-Hydroxyisobutyrate dehydrogenase
HL650_RS08670	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
HL650_RS08680	ENOG4107Y70	Heat shock protein
HL650_RS08695	ENOG4105DZ1	carboxypeptidase
HL650_RS08700	ENOG4105DEU	major facilitator superfamily
HL650_RS08710	ENOG4105K8I	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)
HL650_RS08715	ENOG4108KVX	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity)
HL650_RS08730	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
HL650_RS08735	ENOG4105DIN	metallophosphoesterase
HL650_RS08745	ENOG4105DZ1	carboxypeptidase
HL650_RS08760	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
HL650_RS08765	ENOG4105VCC	30S ribosomal protein S21
HL650_RS08770	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
HL650_RS08795	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
HL650_RS08800	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
HL650_RS08805	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
HL650_RS08810	ENOG4105D52	delta-aminolevulinic acid dehydratase
HL650_RS08825	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
HL650_RS08830	ENOG4105CFT	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity)
HL650_RS08855	ENOG41081F0	Precorrin-8x methylmutase
HL650_RS08865	ENOG4107QZB	decarboxylase
HL650_RS08880	ENOG4108YZT	Adenosylcobinamide kinase
HL650_RS08885	ENOG4107XPA	Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity)
HL650_RS08895	ENOG4105CUP	Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity)
HL650_RS08900	ENOG4105C0Y	Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
HL650_RS08905	ENOG4108JTQ	reductase
HL650_RS08910	ENOG4105E4R	Precorrin-3B C17-methyltransferase
HL650_RS08915	ENOG4108P62	biosynthesis protein (CbiG)
HL650_RS08920	ENOG4105CIA	precorrin-4 C(11)-methyltransferase
HL650_RS08925	ENOG4105DVK	Precorrin-2 c20-methyltransferase
HL650_RS08935	ENOG4105DXU	ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity)
HL650_RS08950	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
HL650_RS08955	ENOG410908R	Methenyltetrahydrofolate cyclohydrolase
HL650_RS08980	ENOG4105EYX	Acetyl-CoA decarbonylase synthase complex subunit gamma
HL650_RS08985	ENOG4106HYN	CO dehydrogenase acetyl-CoA synthase delta subunit
HL650_RS08990	ENOG4105E8X	CO dehydrogenase acetyl-CoA synthase complex beta subunit
HL650_RS08995	ENOG41080XS	Cobyrinic acid ac-diamide synthase
HL650_RS09000	ENOG4105CJG	carbon-monoxide dehydrogenase catalytic subunit
HL650_RS09005	ENOG41080XS	Cobyrinic acid ac-diamide synthase
HL650_RS09010	ENOG4105SYT	Methylenetetrahydrofolate reductase
HL650_RS09025	ENOG4105EYH	Exonuclease
HL650_RS09030	ENOG4107RFY	SbcCD D subunit
HL650_RS09040	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HL650_RS09050	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HL650_RS09055	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
HL650_RS09060	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
HL650_RS09065	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
HL650_RS09075	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
HL650_RS09085	ENOG4105DBW	Multi-copper polyphenol oxidoreductase laccase
HL650_RS09090	ENOG4105VFF	UPF0102 protein
HL650_RS09095	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
HL650_RS09100	ENOG4105C9W	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity)
HL650_RS09110	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
HL650_RS09125	ENOG4105DBZ	Dtdp-4-dehydrorhamnose reductase
HL650_RS09130	ENOG41090E6	transcriptional regulator MERR family
HL650_RS09145	ENOG4108KGH	TRANSCRIPTIONal
HL650_RS09150	ENOG4105KFN	sortase, SrtB family
HL650_RS09165	ENOG4108RB3	Capsular polysaccharide biosynthesis protein
HL650_RS09230	ENOG4105K64	Glycosyl transferase, family 2
HL650_RS09240	ENOG4105EVB	acetyltransferase
HL650_RS09250	ENOG4107ZBH	radical SAM domain protein
HL650_RS09260	ENOG4105CPK	Glycosyl transferase (Group 1
HL650_RS09270	ENOG4105CG5	Glycosyl transferase (Group 1
HL650_RS09290	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
HL650_RS09295	ENOG4107Z8R	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
HL650_RS09300	ENOG4105VB6	UPF0109 protein
HL650_RS09345	ENOG4105DVM	PP-loop domain protein
HL650_RS09350	ENOG4105C8M	UPF0272 protein
HL650_RS09365	ENOG4105C7B	Threonine dehydratase
HL650_RS09370	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
HL650_RS09375	ENOG4105CDB	Required for chromosome condensation and partitioning (By similarity)
HL650_RS09380	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
HL650_RS09385	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
HL650_RS09390	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
HL650_RS09400	ENOG41067VY	50S ribosomal protein L32
HL650_RS09425	ENOG4105CE1	Ferrous iron transport protein b
HL650_RS09440	ENOG4105CAG	UPF0210 protein
HL650_RS09445	ENOG4105VUC	UPF0237 protein
HL650_RS09450	ENOG4105Q2H	domain protein
HL650_RS09455	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
HL650_RS09460	ENOG4105C2M	dna polymerase I
HL650_RS09465	ENOG4108S4H	thioesterase Superfamily protein
HL650_RS09475	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
HL650_RS09495	ENOG4105W8V	TRANSCRIPTIONAl REGULATOR GntR family
HL650_RS09500	ENOG41082UD	thioesterase Superfamily protein
HL650_RS09510	ENOG4105CFH	Aspartokinase
HL650_RS09515	ENOG4105CHM	Aminotransferase
HL650_RS09520	ENOG4108ZB6	transcriptional regulator AsnC family
HL650_RS09530	ENOG4105E0C	molybdate abc transporter
HL650_RS09535	ENOG4108S6J	ABC transporter, periplasmic molybdate-binding protein
HL650_RS09550	ENOG410631K	Membrane
HL650_RS09570	ENOG4107R73	Mate efflux family protein
HL650_RS09585	ENOG4105CXT	aspartate transcarbamylase
HL650_RS09625	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HL650_RS09630	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
HL650_RS09635	ENOG4105C4Q	deoxyguanosinetriphosphate triphosphohydrolase-like protein
HL650_RS09640	ENOG4105EFU	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity)
HL650_RS09650	ENOG4107S4Z	Activates expression of the rhaBAD and rhaT operons (By similarity)
HL650_RS09680	ENOG4108RDQ	ABC transporter
HL650_RS09725	ENOG4105DY9	regulatoR
HL650_RS09750	ENOG4105DFH	Transport of potassium into the cell (By similarity)
HL650_RS09755	ENOG4105C3D	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
HL650_RS09770	ENOG4105DZP	Membrane-associated zinc metalloprotease
HL650_RS09780	ENOG4105KNE	Phosphatidate cytidylyltransferase
HL650_RS09785	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
HL650_RS09790	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
HL650_RS09805	ENOG4105C8J	)-transporter
HL650_RS09815	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
HL650_RS09825	ENOG4107VWA	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity)
HL650_RS09830	ENOG4107XGZ	Hydrolase
HL650_RS09835	ENOG4105UQX	Mate efflux family protein
HL650_RS09840	ENOG4105D1Q	UPF0246 protein
HL650_RS09845	ENOG4105MN5	HAD-superfamily hydrolase subfamily IA variant 3
HL650_RS09860	ENOG4105BZU	Histidine kinase
HL650_RS09880	ENOG4107QI1	Mate efflux family protein
HL650_RS09910	ENOG4107UIE	peptidase
HL650_RS09915	ENOG4105D29	Helix-turn-helix type 11 domain protein
HL650_RS09930	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
HL650_RS09940	ENOG4105DA5	(ABC) transporter
HL650_RS09945	ENOG4105FDP	GntR family transcriptional regulator
HL650_RS09970	ENOG41080H2	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity)
HL650_RS09975	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
HL650_RS09980	ENOG4108IEG	Formate dehydrogenase Alpha subunit
HL650_RS09985	ENOG4107QIZ	NADH dehydrogenase
HL650_RS10015	ENOG4105W2C	Glycosyl transferase
HL650_RS10020	ENOG4105BZF	Glycosyl transferase (Group 1
HL650_RS10215	ENOG4105QBX	endodeoxyribonuclease RusA
HL650_RS10230	ENOG4108PNI	recT protein
HL650_RS10240	ENOG4108NF7	phage-type endonuclease
HL650_RS10320	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
HL650_RS10330	ENOG4107QK3	aspartate-semialdehyde dehydrogenase (EC 1.2.1.11
HL650_RS10335	ENOG4105CH7	arginosuccinase
HL650_RS10345	ENOG4105C5I	Dehydrogenase
HL650_RS10355	ENOG4105EFP	binding-protein-dependent transport systems inner membrane Component
HL650_RS10370	ENOG4105C22	threonyL-tRNA synthetase
HL650_RS10380	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
HL650_RS10405	ENOG4108VAC	response regulator
HL650_RS10410	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
HL650_RS10430	ENOG4108HM4	ABC transporter
HL650_RS10435	ENOG4105D38	putrescine abc transporter
HL650_RS10440	ENOG4105F38	ABC transporter, permease
HL650_RS10445	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
HL650_RS10455	ENOG4105FDF	Could be involved in DNA repair (By similarity)
HL650_RS10460	ENOG4108J9Q	DNA ligase
HL650_RS10475	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
HL650_RS10485	ENOG4105D64	Mechanosensitive ion channel
HL650_RS10490	ENOG4105C9C	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity)
HL650_RS10495	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
HL650_RS10515	ENOG4107QIZ	NADH dehydrogenase
HL650_RS10520	ENOG4107QHI	-hydrogenase
HL650_RS10525	ENOG4108YM7	Gcn5-related n-acetyltransferase
HL650_RS10530	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
HL650_RS10540	ENOG4107QW8	radical SAM domain protein
HL650_RS10555	ENOG4108JQ1	Dehydrogenase
HL650_RS10560	ENOG4107QM1	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity)
HL650_RS10565	ENOG4105C7K	acetolactate synthase
HL650_RS10570	ENOG4105C01	Dihydroxy-acid dehydratase
HL650_RS10605	ENOG4105TIV	Cryptic phage CTXphi transcriptional repressor RstR
HL650_RS10615	ENOG4107QHI	-hydrogenase
HL650_RS10620	ENOG41086D8	Transcriptional regulator
HL650_RS10625	ENOG4105EJQ	L-serine dehydratase
HL650_RS10640	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
HL650_RS10660	ENOG4105BZU	Histidine kinase
HL650_RS10665	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HL650_RS10695	ENOG4105EB3	Histidine kinase
HL650_RS10725	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
HL650_RS10730	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
HL650_RS10735	ENOG4105XZU	Preprotein translocase, subunit SecG
HL650_RS10740	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
HL650_RS10775	ENOG4107S4Z	Activates expression of the rhaBAD and rhaT operons (By similarity)
HL650_RS10780	ENOG4105CJI	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
HL650_RS10785	ENOG4105CDA	abc transporter atp-binding protein
HL650_RS10790	ENOG4105E5Q	amino acid AbC transporter
HL650_RS10795	ENOG4108HW3	(ABC) transporter
HL650_RS10810	ENOG4105CP7	Triose-phosphate isomerase
HL650_RS10825	ENOG4107RVV	histidinol phosphate phosphatase, hisj family
HL650_RS10830	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
HL650_RS10835	ENOG4107XTC	May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins
HL650_RS10845	ENOG4108ZF1	Transcriptional regulator, BadM Rrf2 family
HL650_RS10875	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HL650_RS10885	ENOG4105E4Y	Endoribonuclease that initiates mRNA decay (By similarity)
HL650_RS10890	ENOG4105Y3E	Modulates RecA activity (By similarity)
HL650_RS10895	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
HL650_RS10915	ENOG4105C19	ABC transporter
HL650_RS10920	ENOG4105EAY	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HL650_RS10925	ENOG4105EWM	Histidine kinase
HL650_RS10930	ENOG4105CJZ	response regulator
HL650_RS10935	ENOG4105CXW	Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity)
HL650_RS10940	ENOG4107QQR	Sporulation
HL650_RS10945	ENOG4105S1Z	Stage IV sporulation protein B
HL650_RS10950	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
HL650_RS10955	ENOG4105XBY	Regulates arginine biosynthesis genes (By similarity)
HL650_RS10960	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
HL650_RS10965	ENOG4105DX0	Hemolysin A
HL650_RS10970	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
HL650_RS10980	ENOG41067QG	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
HL650_RS10990	ENOG4105M7K	Involved in the transcription termination process (By similarity)
HL650_RS10995	ENOG4108ZSR	alkaline shock protein
HL650_RS11005	ENOG4105C8A	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity)
HL650_RS11045	ENOG4105CD2	stage iii sporulation protein aa
HL650_RS11060	ENOG4105T16	Transcriptional regulator (AraC family)
HL650_RS11065	ENOG4108Z5V	transcriptional regulator, merr family
HL650_RS11070	ENOG4105CPC	Aldo Keto reductase
HL650_RS11080	ENOG4105ENA	helicase
HL650_RS11085	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
HL650_RS11100	ENOG4105DRS	transport system, permease
HL650_RS11110	ENOG4108IJG	ABC transporter substrate-binding protein
HL650_RS11125	ENOG4108UTP	(2Fe-2S)-binding domain protein
HL650_RS11130	ENOG4108HR6	Dehydrogenase
HL650_RS11135	ENOG4105C7W	Xanthine dehydrogenase
HL650_RS11155	ENOG4105DRW	binding-protein-dependent transport systems inner membrane Component
HL650_RS11160	ENOG4105F0P	binding-protein-dependent transport systems inner membrane Component
HL650_RS11165	ENOG4105C2F	Histidine kinase
HL650_RS11170	ENOG4105EQD	regulatoR
HL650_RS11190	ENOG4105EA8	2-Nitropropane dioxygenase
HL650_RS11200	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
HL650_RS11205	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
HL650_RS11210	ENOG4105KM4	Acetyl-CoA carboxylase, biotin carboxyl carrier protein
HL650_RS11215	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
HL650_RS11220	ENOG4105CHR	reductase
HL650_RS11225	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
HL650_RS11235	ENOG4105CNI	cell division protein FtsW
HL650_RS11240	ENOG4108QXE	glycerophosphoryl diester phosphodiesterase
HL650_RS11255	ENOG4105DZS	Phenylacetate-CoA ligase
HL650_RS11285	ENOG4105CHR	reductase
HL650_RS11290	ENOG4105CPQ	Dehydrogenase
HL650_RS11295	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
HL650_RS11305	ENOG4105DR6	Trap dicarboxylate transporter, dctp subunit
HL650_RS11315	ENOG4107YCY	Transcriptional regulator
HL650_RS11335	ENOG4108MCI	Transcriptional regulator, ARAC family
HL650_RS11345	ENOG4105DB7	PHP domain protein
HL650_RS11355	ENOG4105E2R	ROK family
HL650_RS11365	ENOG4105WEF	catalase
HL650_RS11370	ENOG4108Z7T	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
HL650_RS11380	ENOG4107QW4	alcohol dehydrogenase
HL650_RS11395	ENOG4105CJQ	hydrolase, family 31
HL650_RS11400	ENOG4105C1J	atp-dependent rna helicase
HL650_RS11410	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
HL650_RS11420	ENOG4105D29	Helix-turn-helix type 11 domain protein
HL650_RS11430	ENOG4105KT7	mgtC SapB transporter
HL650_RS11440	ENOG4105DJ4	phosphatidylserine decarboxylase
HL650_RS11465	ENOG4108BRW	Activates expression of the rhaSR operon in response to L-rhamnose (By similarity)
HL650_RS11470	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
HL650_RS11475	ENOG4107QM2	Aldo Keto reductase
HL650_RS11485	ENOG4105CEM	UPF0597 protein
HL650_RS11490	ENOG4105EQD	regulatoR
HL650_RS11505	ENOG4107YY3	extracellular solute-binding protein family 1
HL650_RS11515	ENOG4105C2F	Histidine kinase
HL650_RS11535	ENOG4105DRS	transport system, permease
HL650_RS11540	ENOG4105F0P	binding-protein-dependent transport systems inner membrane Component
HL650_RS11545	ENOG4108JE9	extracellular solute-binding protein family 1
HL650_RS11550	ENOG4108HKT	sucrose-6-phosphate hydrolase
HL650_RS11555	ENOG4105ETE	Transcriptional regulator (LacI family
HL650_RS11560	ENOG4105D9H	Catalyzes the attachment of glycine to tRNA(Gly) (By similarity)
HL650_RS11565	ENOG4108SAY	Involved in DNA repair and RecF pathway recombination (By similarity)
HL650_RS11590	ENOG4108QXE	glycerophosphoryl diester phosphodiesterase
HL650_RS11605	ENOG41062ES	Transcriptional regulator
HL650_RS11610	ENOG4105C5H	ABC transporter
HL650_RS11615	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
HL650_RS11620	ENOG4105DND	Transcriptional regulator
HL650_RS11635	ENOG41067TZ	transcriptional regulator, MarR family
HL650_RS11645	ENOG4105DKQ	ROK family
HL650_RS11650	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
HL650_RS11655	ENOG4107QYD	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
HL650_RS11665	ENOG4105G7B	Protein of unknown function (DUF2992)
HL650_RS11770	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HL650_RS11790	ENOG4105CVG	Homoserine O-transsuccinylase
HL650_RS11795	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
HL650_RS11800	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
HL650_RS11805	ENOG4105FE9	pseudouridine synthase
HL650_RS11850	ENOG4108WJV	had superfamily (subfamily IIIa) phosphatase
HL650_RS11860	ENOG4105KTU	Transcriptional regulator, arsr family
HL650_RS11870	ENOG4108JPM	phospho-2-dehydro-3-deoxyheptonate aldolase
HL650_RS11875	ENOG4105BZ1	(ABC) transporter
HL650_RS11890	ENOG4107R73	Mate efflux family protein
HL650_RS11895	ENOG4105CHM	Aminotransferase
HL650_RS11900	ENOG4108JQ7	(ABC) transporter
HL650_RS11910	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
HL650_RS11920	ENOG4105DEF	Extracellular solute-binding protein, family 5
HL650_RS11925	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
HL650_RS11940	ENOG4105DER	m42 family
HL650_RS11960	ENOG4105E65	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HL650_RS11975	ENOG4105CZZ	Alpha-N-arabinofuranosidase (EC 3.2.1.55)
HL650_RS12000	ENOG4108UHU	Aldolase
HL650_RS12005	ENOG4105J4Q	Transcriptional regulator
HL650_RS12010	ENOG4105DAV	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HL650_RS12020	ENOG4105FF2	Type I DHQase
HL650_RS12025	ENOG4105E2X	shikimate dehydrogenase
HL650_RS12040	ENOG4108RIR	Molybdenum cofactor biosynthesis protein
HL650_RS12050	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
HL650_RS12060	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
HL650_RS12065	ENOG4105CNI	cell division protein FtsW
HL650_RS12070	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
HL650_RS12075	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
HL650_RS12080	ENOG4105CJN	penicillin-binding protein
HL650_RS12085	ENOG4105CJN	penicillin-binding protein
HL650_RS12100	ENOG4108V6E	Cell division protein mraZ
HL650_RS12115	ENOG4105C3G	gtp-binding protein
HL650_RS12120	ENOG4105FJ0	thiamine
HL650_RS12140	ENOG4105D9P	serine threonine protein kinase
HL650_RS12145	ENOG4108ZF3	Phosphatase
HL650_RS12150	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
HL650_RS12155	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
HL650_RS12175	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
HL650_RS12180	ENOG4105C5B	carbamate kinase
HL650_RS12200	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
HL650_RS12205	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
HL650_RS12250	ENOG4105XSJ	toxin secretion phage lysis holin
HL650_RS12285	ENOG4105KRQ	Addiction module toxin, Txe YoeB family
HL650_RS12335	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
HL650_RS12345	ENOG4105CAR	Terminase, large subunit
HL650_RS12380	ENOG4105ET3	Reduction of activated sulfate into sulfite (By similarity)
HL650_RS12435	ENOG4105C2M	dna polymerase I
HL650_RS12515	ENOG4107SJB	teichoic acid biosynthesis
HL650_RS12520	ENOG4105EY8	ABC transporter
HL650_RS12530	ENOG4107ZIC	Glycerol-3-phosphate cytidylyltransferase
HL650_RS12535	ENOG4105K64	Glycosyl transferase, family 2
HL650_RS12545	ENOG4107SJB	teichoic acid biosynthesis
HL650_RS12555	ENOG4105K64	Glycosyl transferase, family 2
HL650_RS12590	ENOG4107RGC	Glycosyl transferase, family 2
HL650_RS12595	ENOG4105EY8	ABC transporter
HL650_RS12605	ENOG4108URP	Dtdp-4-dehydrorhamnose 3,5-epimerase
HL650_RS12610	ENOG4105DZ1	carboxypeptidase
HL650_RS12640	ENOG4105KPE	licD family
HL650_RS12645	ENOG4105D5D	udp-galactopyranose mutase
HL650_RS12650	ENOG4105X1N	Glycosyl transferase family 8
HL650_RS12665	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
HL650_RS12675	ENOG4105CKK	Glycosyl transferase, family 2
HL650_RS12685	ENOG4105C12	Phosphoribosylglycinamide synthetase
HL650_RS12690	ENOG4105S7A	ErfK ybiS ycfS ynhG family protein
HL650_RS12715	ENOG4105C8B	TIGR00159 family
HL650_RS12730	ENOG4105MJ2	Competence protein
HL650_RS12735	ENOG4105C7H	Helicase, RecD TraA family
HL650_RS12755	ENOG4105CSA	Coproporphyrinogen iii oxidase
HL650_RS12760	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
HL650_RS12770	ENOG4105CEF	Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity)
HL650_RS12775	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)
HL650_RS12795	ENOG4105BZU	Histidine kinase
HL650_RS12800	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HL650_RS12805	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
HL650_RS12815	ENOG4105D7Q	type ii secretion system
HL650_RS12840	ENOG4105CZX	twitching motility protein
HL650_RS12845	ENOG41067QW	Transcriptional regulator
HL650_RS12855	ENOG4105CDU	Replicative dna helicase
HL650_RS12860	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
HL650_RS12865	ENOG4105BZR	domain protein
HL650_RS12880	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
HL650_RS12885	ENOG4108UUM	single-stranded DNA-binding protein
HL650_RS12890	ENOG4108ZDX	Binds together with S18 to 16S ribosomal RNA (By similarity)
HL650_RS12905	ENOG4105KFN	sortase, SrtB family
HL650_RS12920	ENOG4107RV5	Glycosyl hydrolase family 3 N-terminal domain protein
HL650_RS12930	ENOG4105CG3	alpha amylase, catalytic region
HL650_RS12935	ENOG4108IUJ	4-alpha-glucanotransferase
HL650_RS12940	ENOG4108UW5	maltose o-acetyltransferase
HL650_RS12945	ENOG4105DRI	Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity)
HL650_RS12970	ENOG4105CK5	oxidoreductase
HL650_RS12975	ENOG4105CT4	transporter
HL650_RS12985	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
HL650_RS12990	ENOG4105EB2	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
HL650_RS13020	ENOG4105DRW	binding-protein-dependent transport systems inner membrane Component
HL650_RS13025	ENOG4105F0P	binding-protein-dependent transport systems inner membrane Component
HL650_RS13030	ENOG4105XN3	extracellular solute-binding protein family 1
HL650_RS13035	ENOG4105C84	Histidine ammonia-lyase
HL650_RS13040	ENOG4105DWD	nucleoside recognition domain protein
HL650_RS13055	ENOG4105EAG	UDP-N-acetylglucosamine 2-epimerase
HL650_RS13065	ENOG4105C5E	polysaccharide biosynthesis protein
HL650_RS13075	ENOG4105J5G	Transferase hexapeptide repeat containing protein
HL650_RS13090	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
HL650_RS13105	ENOG4105EQK	-acetyltransferase
HL650_RS13115	ENOG4105C12	Phosphoribosylglycinamide synthetase
HL650_RS13120	ENOG4105D3Q	Sugar transferase
HL650_RS13125	ENOG4107VBM	3-beta hydroxysteroid dehydrogenase isomerase
HL650_RS13130	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
HL650_RS13165	ENOG4106322	response regulator
HL650_RS13170	ENOG4107ZYJ	bioY protein
HL650_RS13180	ENOG4105CE1	Ferrous iron transport protein b
HL650_RS13225	ENOG4108NEV	two component transcriptional regulator, LytTR family
HL650_RS13230	ENOG4108UW5	maltose o-acetyltransferase
HL650_RS13245	ENOG4105FDP	GntR family transcriptional regulator
HL650_RS13255	ENOG4105BZU	Histidine kinase
HL650_RS13260	ENOG4107XJU	UPF0178 protein
HL650_RS13265	ENOG4105EWM	Histidine kinase
HL650_RS13280	ENOG4105C19	ABC transporter
HL650_RS13290	ENOG4105CE1	Ferrous iron transport protein b
HL650_RS13300	ENOG4108JU6	CBS domain protein
HL650_RS13320	ENOG4108I7H	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HL650_RS13325	ENOG4105BZG	amino acid carrier protein
HL650_RS13330	ENOG4105DCF	alanine dehydrogenase
HL650_RS13350	ENOG4105VTR	Integrase
HL650_RS13360	ENOG4105BZ1	(ABC) transporter
HL650_RS13390	ENOG4108HMR	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
HL650_RS13395	ENOG4108IUS	Transketolase
HL650_RS13400	ENOG4108HHA	Transketolase
HL650_RS13420	ENOG4105DRW	binding-protein-dependent transport systems inner membrane Component
HL650_RS13425	ENOG4105F0P	binding-protein-dependent transport systems inner membrane Component
HL650_RS13435	ENOG4107YI1	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
HL650_RS13470	ENOG41067MG	lrgb family
HL650_RS13485	ENOG4105C4C	beta-galactosidase
HL650_RS13490	ENOG4105CNT	hydrolase family 2
HL650_RS13515	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
HL650_RS13530	ENOG4108S0H	Dipicolinic acid synthetase, b subunit
HL650_RS13535	ENOG4105CAQ	asparagine synthetase
HL650_RS13540	ENOG4108R96	Methyltransferase, YaeB family
HL650_RS13545	ENOG4105BZU	Histidine kinase
HL650_RS13575	ENOG4105DA5	(ABC) transporter
HL650_RS13590	ENOG4105DA5	(ABC) transporter
HL650_RS13600	ENOG4105JVQ	RNA Polymerase
HL650_RS13610	ENOG4105F0H	myo-inositol catabolism protein
HL650_RS13615	ENOG4105CJK	Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity)
HL650_RS13625	ENOG4105WZ4	isomerase
HL650_RS13630	ENOG4105DRI	Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity)
HL650_RS13635	ENOG4105FKQ	transcriptional regulator
HL650_RS13640	ENOG4105DY9	regulatoR
HL650_RS13660	ENOG4105EMA	Periplasmic binding protein LacI transcriptional regulator
HL650_RS13670	ENOG4105C2F	Histidine kinase
HL650_RS13675	ENOG4105EQD	regulatoR
HL650_RS13680	ENOG4107R2W	ABC transporter, permease
HL650_RS13685	ENOG4105C2J	ABC transporter
HL650_RS13690	ENOG4105EMA	Periplasmic binding protein LacI transcriptional regulator
HL650_RS13695	ENOG4108NEV	two component transcriptional regulator, LytTR family
HL650_RS13710	ENOG4105F66	Binding-protein-dependent transport systems inner membrane component
HL650_RS13715	ENOG4105DB9	Binding-protein-dependent transport systems inner membrane component
HL650_RS13725	ENOG4105ETE	Transcriptional regulator (LacI family
HL650_RS13780	ENOG4105F5V	trimethylamine methyltransferase
HL650_RS13785	ENOG4108Q52	Methyltransferase cognate corrinoid protein
HL650_RS13805	ENOG4105CJ1	ABC, transporter
HL650_RS13830	ENOG4105CJ1	ABC, transporter
HL650_RS13870	ENOG4105DA5	(ABC) transporter
HL650_RS13885	ENOG4105CV9	cyclopropane-fatty-acyl-phospholipid synthase
HL650_RS13920	ENOG4105BZU	Histidine kinase
HL650_RS13945	ENOG4108K8K	Transcriptional regulator
HL650_RS14005	ENOG4105ETX	regulatoR
HL650_RS14020	ENOG4107YDN	peptide deformylase
HL650_RS14085	ENOG4105CE5	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity)
HL650_RS14095	ENOG4105IES	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity)
HL650_RS14105	ENOG4105KEG	ribosomal-protein-alanine acetyltransferase
HL650_RS14110	ENOG41072GX	Peptidase M22 Glycoprotease
HL650_RS14115	ENOG4105K8N	protein family UPF0079, ATPase
HL650_RS14120	ENOG4107ZE5	PPIases accelerate the folding of proteins
HL650_RS14125	ENOG4108ZK7	protein family UPF0029, Impact, N-terminal protein
HL650_RS14140	ENOG4105D1C	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity)
HL650_RS14145	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
HL650_RS14155	ENOG4105DPH	UPF0371 protein
HL650_RS14160	ENOG4105CMR	udp-glucose 4-epimerase
HL650_RS14210	ENOG4106050	phage regulatory protein, rha family
HL650_RS14535	ENOG4105ECQ	AraC Family Transcriptional Regulator
HL650_RS14540	ENOG4105CKA	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity)
HL650_RS14545	ENOG4105RHA	ABC transporter, permease
HL650_RS14550	ENOG4108IUX	(ABC) transporter
HL650_RS14560	ENOG4105VZ8	Transcriptional regulator
HL650_RS14580	ENOG4105C59	p-type ATPase
HL650_RS14590	ENOG4105C1A	potassium transporter peripheral membrane
HL650_RS14595	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
HL650_RS14600	ENOG4105WEF	catalase
HL650_RS14625	ENOG4105BZU	Histidine kinase
HL650_RS14630	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HL650_RS14635	ENOG4105EAM	Na Pi-cotransporter
HL650_RS14640	ENOG4105EPI	acetyltransferase, (GNAT) family
HL650_RS14665	ENOG4107YHV	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
HL650_RS14675	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
HL650_RS14685	ENOG4105D0I	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity)
HL650_RS14715	ENOG4108TQ9	Histidine kinase
HL650_RS14730	ENOG4105EXG	Transcriptional regulator
HL650_RS14785	ENOG4105C08	Histidine kinase
HL650_RS14790	ENOG4108R80	One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity)
HL650_RS14795	ENOG4105C8X	One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity)
HL650_RS14800	ENOG4105D9K	One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity)
HL650_RS14835	ENOG4107YZP	Rhodanese domain protein
HL650_RS14840	ENOG4105CZF	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
HL650_RS14845	ENOG4108JYZ	YitT family
HL650_RS14870	ENOG4105E2R	ROK family
HL650_RS14875	ENOG4105DBI	uridine monophosphokinase
HL650_RS14885	ENOG4105CPN	adenine deaminase
HL650_RS14890	ENOG4105C7N	Xanthine uracil vitamin C permease
HL650_RS14915	ENOG4105KMT	branched-chain amino acid
HL650_RS14920	ENOG4108UMN	azlc family
HL650_RS14930	ENOG4105NAE	bifunctional deaminase-reductase domain protein
HL650_RS14940	ENOG41067QW	Transcriptional regulator
HL650_RS14945	ENOG4105D8W	glucose-6-phosphate 1-dehydrogenase
HL650_RS14950	ENOG4105C7Q	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity)
HL650_RS14955	ENOG4105HHQ	6-phosphogluconolactonase (EC 3.1.1.31)
HL650_RS14960	ENOG4105E66	phosphoriboisomerase A
HL650_RS15000	ENOG4105DRS	transport system, permease
HL650_RS15005	ENOG4105F0P	binding-protein-dependent transport systems inner membrane Component
HL650_RS15020	ENOG4105EQD	regulatoR
HL650_RS15025	ENOG4108HRK	Histidine kinase
HL650_RS15035	ENOG4108W3Q	Transcriptional regulator
HL650_RS15050	ENOG4105C50	Binding-protein-dependent transport systems, inner membrane component
HL650_RS15065	ENOG4105CNT	hydrolase family 2
HL650_RS15075	ENOG41063ZK	Transcriptional Regulator AraC Family
HL650_RS15095	ENOG410804X	Transcriptional regulator
HL650_RS15105	ENOG4108JQ7	(ABC) transporter
HL650_RS15110	ENOG4105C3U	ABC transporter
HL650_RS15115	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
HL650_RS15120	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
HL650_RS15125	ENOG4108J59	Extracellular solute-binding protein, family 5
HL650_RS15205	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
HL650_RS15210	ENOG4105EQI	Metal Dependent Phosphohydrolase
HL650_RS15215	ENOG4105C0H	protease
HL650_RS15220	ENOG4105C98	muts2 protein
HL650_RS15225	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HL650_RS15230	ENOG4105BZU	Histidine kinase
HL650_RS15240	ENOG4107QIK	phosphoribosylformylglycinamidine synthase
HL650_RS15275	ENOG4107RWR	Sodium hydrogen exchanger
HL650_RS15280	ENOG4105CJD	(Anaerobic) ribonucleoside-triphosphate reductase
HL650_RS15285	ENOG4107QI1	Mate efflux family protein
HL650_RS15295	ENOG410810Y	Sulfite reductase
HL650_RS15300	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
HL650_RS15310	ENOG4105VCQ	rubredoxin
HL650_RS15320	ENOG4105DFD	Na H antiporter
HL650_RS15325	ENOG4105C84	Histidine ammonia-lyase
HL650_RS15335	ENOG4105DS0	Transcriptional regulator, Crp Fnr family
HL650_RS15355	ENOG4105F0P	binding-protein-dependent transport systems inner membrane Component
HL650_RS15360	ENOG4105BZ7	extracellular solute-binding protein family 1
HL650_RS15365	ENOG4105FTV	AraC Family Transcriptional Regulator
HL650_RS15370	ENOG4105D2N	Aldolase
HL650_RS15385	ENOG4105CJK	Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity)
HL650_RS15390	ENOG4105CK5	oxidoreductase
HL650_RS15395	ENOG4105WBN	Transcriptional regulator (LacI family
HL650_RS15415	ENOG4105EQD	regulatoR
HL650_RS15420	ENOG4105C2F	Histidine kinase
HL650_RS15425	ENOG4105DRI	Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity)
HL650_RS15435	ENOG4105CT4	transporter
HL650_RS15455	ENOG4108HRG	Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity)
HL650_RS15460	ENOG4105D7K	pfkb domain protein
HL650_RS15465	ENOG4105ETE	Transcriptional regulator (LacI family
HL650_RS15495	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
HL650_RS15545	ENOG4105DQ6	Transposase
HL650_RS15765	ENOG4105QBX	endodeoxyribonuclease RusA
HL650_RS15780	ENOG4108PNI	recT protein
HL650_RS15790	ENOG4108NF7	phage-type endonuclease
HL650_RS15885	ENOG4105M59	Phosphodiesterase, mj0936 family
HL650_RS15890	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
HL650_RS15895	ENOG4105C4H	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity)
HL650_RS15900	ENOG4108RE9	Phosphodiesterase
HL650_RS15920	ENOG4105CJQ	hydrolase, family 31
HL650_RS15945	ENOG4107KJX	Transcriptional regulator
HL650_RS15960	ENOG4105F55	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity)
HL650_RS15965	ENOG4105DKQ	ROK family
HL650_RS15980	ENOG4105E4X	binding-protein-dependent transport systems inner membrane Component
HL650_RS15985	ENOG4108JE9	extracellular solute-binding protein family 1
HL650_RS15990	ENOG4105E2R	ROK family
HL650_RS16005	ENOG4105CHM	Aminotransferase
HL650_RS16010	ENOG4105BZ1	(ABC) transporter
HL650_RS16020	ENOG4107V9H	nitrite transporter
HL650_RS16025	ENOG4105CKU	formyltetrahydrofolate synthetase
HL650_RS16030	ENOG4105D7K	pfkb domain protein
HL650_RS16035	ENOG4108IQD	Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity)
HL650_RS16040	ENOG4105CK0	Membrane bOund o-acyl transferase mboat family protein
HL650_RS16050	ENOG4108M4D	D-alanyl-lipoteichoic acid biosynthesis protein DltD
HL650_RS16060	ENOG4105EEX	Two component transcriptional regulator (Winged helix family
HL650_RS16065	ENOG4105C08	Histidine kinase
HL650_RS16080	ENOG4108REF	Sporulation integral membrane protein ytvi
HL650_RS16135	ENOG4105F66	Binding-protein-dependent transport systems inner membrane component
HL650_RS16140	ENOG4105DB9	Binding-protein-dependent transport systems inner membrane component
HL650_RS16150	ENOG4105C2F	Histidine kinase
HL650_RS16155	ENOG4105EQD	regulatoR
HL650_RS16165	ENOG4107RRE	RNA-directed DNA polymerase
HL650_RS16185	ENOG4105D50	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate (By similarity)
HL650_RS16190	ENOG4107XVH	Transcriptional regulator
HL650_RS16210	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
HL650_RS16245	ENOG4105CNT	hydrolase family 2
HL650_RS16250	ENOG4105UQX	Mate efflux family protein
HL650_RS16255	ENOG4108CIP	transcriptional regulator
HL650_RS16270	ENOG4105C50	Binding-protein-dependent transport systems, inner membrane component
HL650_RS16280	ENOG4105ETE	Transcriptional regulator (LacI family
HL650_RS16300	ENOG4105DC7	peptidase M24
HL650_RS16310	ENOG4105CMG	Carbohydrate kinase
HL650_RS16335	ENOG4105E3H	phosphoglycerate mutase
HL650_RS16340	ENOG4105D6E	homoserine dehydrogenase
HL650_RS16345	ENOG41090I5	UPF0735 ACT domain-containing protein
HL650_RS16360	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
HL650_RS16365	ENOG4105CIZ	coA-substrate-specific enzyme activase
HL650_RS16375	ENOG4105MS2	ribosomal subunit Interface protein
HL650_RS16385	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
HL650_RS16390	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
HL650_RS16395	ENOG41068B1	Cob-I-yrinic acid a,c-diamide adenosyltransferase
HL650_RS16405	ENOG4105CI3	gtp-binding protein typa
HL650_RS16410	ENOG4105C0A	alcohol dehydrogenase
HL650_RS16420	ENOG4108ZJ4	polysaccharide deacetylase
HL650_RS16425	ENOG4105BZG	amino acid carrier protein
HL650_RS16435	ENOG4108UI1	Probably functions as a manganese efflux pump (By similarity)
HL650_RS16455	ENOG4105BZU	Histidine kinase
HL650_RS16480	ENOG4107VQW	regulatoR
HL650_RS16485	ENOG4105C2F	Histidine kinase
HL650_RS16555	ENOG4107S9D	Alpha beta hydrolase
HL650_RS16560	ENOG4107Y80	Major Facilitator superfamily
HL650_RS16575	ENOG4108IG5	Transcriptional regulator
HL650_RS16585	ENOG4105CGH	5'-nucleotidase
HL650_RS16620	ENOG4105EQD	regulatoR
HL650_RS16625	ENOG4105C2F	Histidine kinase
HL650_RS16645	ENOG4108HKT	sucrose-6-phosphate hydrolase
HL650_RS16655	ENOG4105C50	Binding-protein-dependent transport systems, inner membrane component
HL650_RS16665	ENOG4105FKQ	transcriptional regulator
HL650_RS16710	ENOG4108KQY	
HL650_RS16750	ENOG4108NEV	two component transcriptional regulator, LytTR family
HL650_RS16785	ENOG4108IUW	ABC transporter
HL650_RS16790	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
HL650_RS16795	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
HL650_RS16800	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
HL650_RS16845	ENOG4105EZY	Pyrroloquinoline quinone biosynthesis protein E
HL650_RS16850	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
HL650_RS16855	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
HL650_RS16880	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
HL650_RS16890	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
HL650_RS16895	ENOG4105E2R	ROK family
HL650_RS16905	ENOG4105C3I	Nad-dependent epimerase dehydratase
HL650_RS16930	ENOG4105EKQ	RNA-directed DNA polymerase
HL650_RS16960	ENOG4105MT0	Sporulation transcriptional regulator spoiiid
HL650_RS16970	ENOG4105EGY	DNA internalization-related competence protein ComEC Rec2
HL650_RS16975	ENOG4108UVJ	appr-1-p processing domain protein
HL650_RS16980	ENOG4107QJQ	Mate efflux family protein
HL650_RS16985	ENOG4105HHQ	6-phosphogluconolactonase (EC 3.1.1.31)
HL650_RS17000	ENOG4105EQD	regulatoR
HL650_RS17015	ENOG4108ITV	Inner membrane protein yqcE
HL650_RS17035	ENOG4105KXQ	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
HL650_RS17065	ENOG4105E9V	Periplasmic binding protein LacI transcriptional regulator
HL650_RS17075	ENOG4105C34	Pseudouridine synthase
HL650_RS17080	ENOG4107QM5	aconitate hydratase
HL650_RS17085	ENOG4108IXP	Carbohydrate diacid transcriptional activator CdaR
HL650_RS17095	ENOG4105BZU	Histidine kinase
HL650_RS17115	ENOG4107QYV	phosphohexose isomerase
HL650_RS17125	ENOG4105DUF	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity)
HL650_RS17130	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
HL650_RS17145	ENOG4105EWK	phytoene
HL650_RS17170	ENOG4105C3J	Cysteine desulfurase
HL650_RS17180	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
HL650_RS17185	ENOG4105DZS	Phenylacetate-CoA ligase
HL650_RS17195	ENOG4105C01	Dihydroxy-acid dehydratase
HL650_RS17285	ENOG4105DY9	regulatoR
HL650_RS17315	ENOG4108RDQ	ABC transporter
HL650_RS17350	ENOG4105CJ1	ABC, transporter
HL650_RS17355	ENOG4105BZU	Histidine kinase
HL650_RS17360	ENOG4105WH1	Two component transcriptional regulator luxr family
HL650_RS17410	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
HL650_RS17420	ENOG4105K59	histidine triad (HIT) protein
HL650_RS17425	ENOG4105BZU	Histidine kinase
HL650_RS17430	ENOG4107ZXI	Rhomboid family
HL650_RS17435	ENOG4105TV9	FHA Domain-Containing protein
HL650_RS17495	ENOG4108Z66	YbaK ebsC protein
HL650_RS17520	ENOG4105C6K	Malic enzyme
HL650_RS17550	ENOG4108HRK	Histidine kinase
HL650_RS17555	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
HL650_RS17560	ENOG4105C8J	)-transporter
HL650_RS17565	ENOG4105EN6	Membrane
HL650_RS17605	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
HL650_RS17640	ENOG4108JIQ	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit (By similarity)
HL650_RS17645	ENOG4108JIP	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit (By similarity)
HL650_RS17650	ENOG4106C6A	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
HL650_RS17655	ENOG4105BZU	Histidine kinase
HL650_RS17665	ENOG4105C8U	phosphate abc transporter
HL650_RS17670	ENOG4105E2Z	phosphate ABC transporter (Permease
HL650_RS17675	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
HL650_RS17680	ENOG4108UTW	Plays a role in the regulation of phosphate uptake
HL650_RS17690	ENOG4105BZU	Histidine kinase
HL650_RS17695	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
HL650_RS17700	ENOG4105C3M	thioredoxin reductase
HL650_RS17730	ENOG4105E98	transcriptional regulator DeoR family
HL650_RS17735	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
HL650_RS17745	ENOG4105DM4	PTS System
HL650_RS17750	ENOG4105DE4	1-phosphofructokinase
HL650_RS17780	ENOG4107RRD	Dehydrogenase
HL650_RS17800	ENOG4105F66	Binding-protein-dependent transport systems inner membrane component
HL650_RS17805	ENOG4105DB9	Binding-protein-dependent transport systems inner membrane component
HL650_RS17820	ENOG41063TF	transcriptional regulator (AraC
HL650_RS17830	ENOG41083RF	phosphoribosyl-ATP pyrophosphatase
HL650_RS17835	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
HL650_RS17840	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
HL650_RS17850	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
HL650_RS17860	ENOG4105CIH	Imidazole acetol-phosphate transaminase
HL650_RS17865	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
HL650_RS17870	ENOG4108IQ6	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity)
HL650_RS17875	ENOG4105BZU	Histidine kinase
HL650_RS17900	ENOG4105CAH	Chromate
HL650_RS17910	ENOG4105DUM	transcriptional regulator, lysR family
HL650_RS17920	ENOG4108JA2	transcriptioN-repair coupling factor
HL650_RS17935	ENOG4105CKI	cobalamin synthesis protein
HL650_RS17945	ENOG4105C19	ABC transporter
HL650_RS17950	ENOG4105EB3	Histidine kinase
HL650_RS17955	ENOG4108KXV	response regulator
HL650_RS17960	ENOG4105DFD	Na H antiporter
HL650_RS17985	ENOG4108BRW	Activates expression of the rhaSR operon in response to L-rhamnose (By similarity)
HL650_RS17995	ENOG4105CBF	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity)
HL650_RS18005	ENOG4105D06	uba thif-type nad fad binding protein
HL650_RS18010	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
HL650_RS18020	ENOG4108UV6	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
HL650_RS18120	ENOG4105D9P	serine threonine protein kinase
HL650_RS18145	ENOG4108ZF3	Phosphatase
HL650_RS18150	ENOG4105C0H	protease
HL650_RS18165	ENOG4108JGH	Tetr family transcriptional regulator
HL650_RS18170	ENOG4105F8V	Hydrolase, tatD family
HL650_RS18175	ENOG4105C02	permease
HL650_RS18180	ENOG4105C52	Atpase, p-type (Transporting), had superfamily, subfamily ic
HL650_RS18190	ENOG4105CNT	hydrolase family 2
HL650_RS18200	ENOG4105CKA	Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity)
HL650_RS18210	ENOG4105F0P	binding-protein-dependent transport systems inner membrane Component
HL650_RS18220	ENOG4105RD7	BadF BadG BcrA BcrD
HL650_RS18225	ENOG4105F8D	glycoside hydrolase family 4
HL650_RS18230	ENOG4105ETE	Transcriptional regulator (LacI family
HL650_RS18245	ENOG4105CT4	transporter
HL650_RS18250	ENOG4105F0H	myo-inositol catabolism protein
HL650_RS18255	ENOG4107QP6	Xylose isomerase domain protein TIM barrel
HL650_RS18260	ENOG4105CIB	oxidoreductase Domain protein
HL650_RS18265	ENOG4105W4W	Transcriptional regulator
HL650_RS18285	ENOG4105C2F	Histidine kinase
HL650_RS18290	ENOG4105EQD	regulatoR
HL650_RS18295	ENOG4105DRW	binding-protein-dependent transport systems inner membrane Component
HL650_RS18320	ENOG4107R73	Mate efflux family protein
HL650_RS18325	ENOG4105CBC	glutamate synthase
HL650_RS18330	ENOG4105CD3	dihydroorotase
HL650_RS18350	ENOG4105CP7	Triose-phosphate isomerase
HL650_RS18360	ENOG4105DJV	ribulose-phosphate 3-epimerase
HL650_RS18365	ENOG4105CPQ	Dehydrogenase
HL650_RS18370	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
HL650_RS18380	ENOG4105CHR	reductase
HL650_RS18395	ENOG4105EUS	Binding-protein-dependent transport systems, inner membrane component
HL650_RS18400	ENOG4105EUS	Binding-protein-dependent transport systems, inner membrane component
HL650_RS18410	ENOG4105ETE	Transcriptional regulator (LacI family
HL650_RS18415	ENOG4105ETE	Transcriptional regulator (LacI family
HL650_RS18420	ENOG4108JIC	nucleoside recognition domain protein
HL650_RS18430	ENOG4105PNM	synthesis protein
HL650_RS18435	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
HL650_RS18440	ENOG4107S47	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity)
HL650_RS18445	ENOG4105MA4	psp1 domain protein
HL650_RS18450	ENOG4107QMP	dna polymerase iii subunits gamma and tau
HL650_RS18455	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
HL650_RS18460	ENOG4105CXN	decarboxylase
HL650_RS18460	ENOG4105CXN	decarboxylase
HL650_RS18465	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
HL650_RS18500	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HL650_RS18505	ENOG4105BZU	Histidine kinase
HL650_RS18520	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
HL650_RS18525	ENOG4105CHR	reductase
HL650_RS18530	ENOG4105C01	Dihydroxy-acid dehydratase
HL650_RS18535	ENOG4108QBF	Transcriptional regulator
HL650_RS18540	ENOG4105C6Z	Gluconate
HL650_RS18550	ENOG4105CPQ	Dehydrogenase
HL650_RS18560	ENOG4105F66	Binding-protein-dependent transport systems inner membrane component
HL650_RS18565	ENOG4105DB9	Binding-protein-dependent transport systems inner membrane component
HL650_RS18575	ENOG41086D8	Transcriptional regulator
HL650_RS18600	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
HL650_RS18605	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
HL650_RS18610	ENOG4107YAQ	Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity)
HL650_RS18615	ENOG4105CJQ	hydrolase, family 31
HL650_RS18650	ENOG4105PTM	secreted protein
HL650_RS18660	ENOG4105CT4	transporter
HL650_RS18665	ENOG4105CNT	hydrolase family 2
HL650_RS18680	ENOG4107STF	Involved in phosphonate degradation (By similarity)
HL650_RS18695	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
HL650_RS18705	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
HL650_RS18720	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
HL650_RS18735	ENOG4105CZV	ABC transporter
HL650_RS18745	ENOG4105DZ1	carboxypeptidase
HL650_RS18760	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
HL650_RS18765	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HL650_RS18780	ENOG4105VB5	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
HL650_RS18785	ENOG4105C5S	asparaginyl-tRNA synthetase
HL650_RS18790	ENOG4105CHM	Aminotransferase
HL650_RS18805	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
HL650_RS18830	ENOG4105CZX	twitching motility protein
HL650_RS18835	ENOG4107QHF	type ii secretion system protein e
HL650_RS18850	ENOG4105D7Q	type ii secretion system
HL650_RS18875	ENOG4105C9U	ATP-dependent DNA helicase RecQ
HL650_RS18885	ENOG4105BZ8	glutamate synthase
HL650_RS18910	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
HL650_RS18960	ENOG41074FZ	May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity)
HL650_RS18965	ENOG4105X5K	response regulator receiver protein
HL650_RS18975	ENOG4105K4H	Nlp p60 protein
HL650_RS19010	ENOG4106128	DNA-binding helix-turn-helix protein
HL650_RS19015	ENOG4106BHR	ftsk SpoIIIE family protein
HL650_RS19065	ENOG4105DRS	transport system, permease
HL650_RS19080	ENOG4105EQD	regulatoR
HL650_RS19085	ENOG4105C2F	Histidine kinase
HL650_RS19090	ENOG4105BZU	Histidine kinase
HL650_RS19100	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
HL650_RS19110	ENOG4105FA0	parb-like partition protein
HL650_RS19115	ENOG4107QJE	Chromosome Partitioning Protein
HL650_RS19140	ENOG4105CJ1	ABC, transporter
HL650_RS19165	ENOG4105D28	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
HL650_RS19170	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
HL650_RS19175	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
HL650_RS19180	ENOG4108Z7S	Single-stranded nucleic acid binding R3H domain-containing protein
HL650_RS19185	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
HL650_RS19195	ENOG4105M7T	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
HL650_RS19200	ENOG4105VG0	50S ribosomal protein l34
HL650_RS19210	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
HL650_RS19220	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
HL650_RS19225	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HL650_RS19230	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HL650_RS19360	ENOG4105C2M	dna polymerase I
HL650_RS19570	ENOG4105UQX	Mate efflux family protein
HL650_RS19580	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
HL650_RS19590	ENOG4108K5P	(LipO)protein
HL650_RS19610	ENOG4105CE4	GlcNAc 6-P deacetylase
HL650_RS19615	ENOG4105C9S	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity)
HL650_RS19625	ENOG4107RJ1	sodium solute
HL650_RS19630	ENOG4108R66	Conserved Protein
HL650_RS19640	ENOG4105QEK	Transcriptional regulator
HL650_RS19645	ENOG4105N80	Ferric uptake regulator, Fur family
HL650_RS19650	ENOG4105KY8	Rubrerythrin
HL650_RS19655	ENOG4108RAC	Rubrerythrin
HL650_RS19685	ENOG4107QW3	Sucrose phosphorylase
HL650_RS19690	ENOG4108UT2	hemolysin iii
HL650_RS19695	ENOG4105BZU	Histidine kinase
HL650_RS19705	ENOG4107URF	beta-phospho-glucomutase
HL650_RS19710	ENOG4108UW5	maltose o-acetyltransferase
HL650_RS19725	ENOG4108IXP	Carbohydrate diacid transcriptional activator CdaR
HL650_RS19735	ENOG4108Q52	Methyltransferase cognate corrinoid protein
HL650_RS19755	ENOG4108Q52	Methyltransferase cognate corrinoid protein
HL650_RS19780	ENOG4105DRW	binding-protein-dependent transport systems inner membrane Component
HL650_RS19800	ENOG41061DF	Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P (By similarity)
HL650_RS19840	ENOG4105DB9	Binding-protein-dependent transport systems inner membrane component
HL650_RS19845	ENOG4105DRS	transport system, permease
HL650_RS19860	ENOG4108R6W	Transcriptional regulator, ARAC family
HL650_RS19875	ENOG4105HTX	biosynthesis protein
HL650_RS19895	ENOG4105KFN	sortase, SrtB family
HL650_RS19905	ENOG4105D3Q	Sugar transferase
HL650_RS19920	ENOG4108KMV	Glycosyl transferase (Group 1
HL650_RS19935	ENOG4105KPE	licD family
HL650_RS19945	ENOG4105K64	Glycosyl transferase, family 2
HL650_RS19950	ENOG4105K64	Glycosyl transferase, family 2
HL650_RS19965	ENOG4105K64	Glycosyl transferase, family 2
HL650_RS20000	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
HL650_RS20005	ENOG4107XVH	Transcriptional regulator
HL650_RS20045	ENOG4105C87	Aminotransferase class I and II
HL650_RS20055	ENOG4107Z36	nucleotidyl transferase
HL650_RS20070	ENOG4108M14	stage v sporulation protein t
HL650_RS20075	ENOG4105DAP	Nicotinate phosphoribosyltransferase
HL650_RS20080	ENOG4108VXD	carboxy-peptidase
HL650_RS20085	ENOG4106KNT	transcriptional regulator
HL650_RS20090	ENOG4105CPQ	Dehydrogenase
HL650_RS20095	ENOG41061GT	Aldolase
HL650_RS20100	ENOG4105CMG	Carbohydrate kinase
HL650_RS20105	ENOG4105DR6	Trap dicarboxylate transporter, dctp subunit
HL650_RS20115	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
HL650_RS20120	ENOG4105C5I	Dehydrogenase
HL650_RS20170	ENOG4107Y7X	LytTR
HL650_RS20190	ENOG4105QNR	S1 RNA binding domain protein
HL650_RS20195	ENOG41088CC	tellurite resistance protein tehB
HL650_RS20200	ENOG4105C0B	DNA polymerase III (alpha subunit)
HL650_RS20215	ENOG4107ZYR	domain protein
HL650_RS20220	ENOG4105C2N	RNA methyltransferase TrmH family group 3
HL650_RS20240	ENOG4105C7N	Xanthine uracil vitamin C permease
HL650_RS20245	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HL650_RS20270	ENOG4105DBV	ornithine carbamoyltransferase
HL650_RS20275	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
HL650_RS20285	ENOG4105CGM	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity)
HL650_RS20290	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
HL650_RS20295	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
HL650_RS20300	ENOG4105CRK	lysyL-tRNA synthetase
HL650_RS20315	ENOG4107QJE	Chromosome Partitioning Protein
HL650_RS20320	ENOG4105FA0	parb-like partition protein
HL650_RS20355	ENOG4108IMY	Transcriptional regulator
HL650_RS20360	ENOG4108IMY	Transcriptional regulator
HL650_RS20405	ENOG4105EKQ	RNA-directed DNA polymerase
HL650_RS20440	ENOG4105K4H	Nlp p60 protein
HL650_RS20455	ENOG4105C9U	ATP-dependent DNA helicase RecQ
HL650_RS20505	ENOG4105C4X	radical SAM domain protein
HL650_RS20525	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HL650_RS20530	ENOG4105BZU	Histidine kinase
HL650_RS20555	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HL650_RS20675	ENOG4107R3N	Filamentation induced by cAMP protein fic
HL650_RS20695	ENOG4105C3F	Signal peptidase i
HL650_RS20705	ENOG4105GJD	protein, conserved in bacteria
HL650_RS20750	ENOG4105ECY	inositol monophosphatase
HL650_RS20850	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
HL650_RS20855	ENOG4105BZU	Histidine kinase
HL650_RS20860	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HL650_RS20920	ENOG4108R6W	Transcriptional regulator, ARAC family
HL650_RS20925	ENOG4105C3S	Mate efflux family protein
HL650_RS20965	ENOG41067SE	Tetr family transcriptional regulator
HL650_RS20975	ENOG4107TXC	Transcriptional regulator
HL650_RS20985	ENOG4105BZV	Phosphoadenosine phosphosulfate reductase
HL650_RS20990	ENOG4105GTN	ParB Domain Protein Nuclease
HL650_RS21000	ENOG4105CH2	amidohydrolase
HL650_RS21005	ENOG4105DZ1	carboxypeptidase
HL650_RS21010	ENOG4105C7Z	Conserved Protein
HL650_RS21020	ENOG4105F0P	binding-protein-dependent transport systems inner membrane Component
HL650_RS21025	ENOG4105DRS	transport system, permease
HL650_RS21040	ENOG4105CUK	Alpha-N-arabinofuranosidase (EC 3.2.1.55)
HL650_RS21085	ENOG4105F66	Binding-protein-dependent transport systems inner membrane component
HL650_RS21090	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
HL650_RS21095	ENOG4105FTQ	Dna gyrase
HL650_RS21110	ENOG4108KN7	Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity)
HL650_RS21135	ENOG4105CMD	Transcriptional regulator, GntR family
HL650_RS21155	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
HL650_RS21165	ENOG4105BZU	Histidine kinase
HL650_RS21170	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HL650_RS21175	ENOG4105BZU	Histidine kinase
HL650_RS21180	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HL650_RS21190	ENOG4108AEY	RNA polymerase sigma factor
HL650_RS21195	ENOG4108Z5V	transcriptional regulator, merr family
HL650_RS21200	ENOG4108R96	Methyltransferase, YaeB family
HL650_RS21210	ENOG4106AXJ	AraC family transcriptional regulator
HL650_RS21215	ENOG4105D29	Helix-turn-helix type 11 domain protein
HL650_RS21220	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
HL650_RS21235	ENOG4105DZ1	carboxypeptidase
HL650_RS21240	ENOG4105C5I	Dehydrogenase
HL650_RS21245	ENOG4105CPF	Cell wall formation (By similarity)
HL650_RS21260	ENOG4105CJW	magnesium transporter
HL650_RS21275	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HL650_RS21300	ENOG4108IMY	Transcriptional regulator
HL650_RS21335	ENOG4107R95	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
HL650_RS21350	ENOG4105KFN	sortase, SrtB family
HL650_RS21375	ENOG4105KVH	Transcriptional regulator
HL650_RS21405	ENOG4105VPX	protein, conserved in bacteria
HL650_RS21420	ENOG4105C59	p-type ATPase
HL650_RS21430	ENOG4107YCR	Transcriptional regulator, ARSR family
HL650_RS21440	ENOG4105KVH	Transcriptional regulator
HL650_RS21470	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
HL650_RS21560	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
HL650_RS21615	ENOG4105C7H	Helicase, RecD TraA family
HL650_RS21685	ENOG4105FBQ	ATPase associated with various cellular activities aaa_5
HL650_RS21720	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HL650_RS21730	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HL650_RS21745	ENOG4108Z5V	transcriptional regulator, merr family
HL650_RS21770	ENOG4105CI2	imidazolone-5-propionate hydrolase
HL650_RS21785	ENOG4105DEF	Extracellular solute-binding protein, family 5
HL650_RS21790	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
HL650_RS21795	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
HL650_RS21810	ENOG4108JQ7	(ABC) transporter
HL650_RS21815	ENOG4107PP3	Acetylornithine deacetylase
HL650_RS21820	ENOG4108KB1	transcriptional regulator, arac family
HL650_RS21825	ENOG4108ZVT	methylmalonyl-coA epimerase
HL650_RS21830	ENOG4105BZ7	extracellular solute-binding protein family 1
HL650_RS21835	ENOG4105F66	Binding-protein-dependent transport systems inner membrane component
HL650_RS21840	ENOG4105DB9	Binding-protein-dependent transport systems inner membrane component
HL650_RS21845	ENOG4105EMU	Dehydrogenase
HL650_RS21850	ENOG4107VPB	domain protein
HL650_RS21870	ENOG4105F6J	Alpha beta hydrolase fold
HL650_RS21895	ENOG4105WDJ	50S ribosomal protein L33
HL650_RS21905	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
HL650_RS21920	ENOG4105EKQ	RNA-directed DNA polymerase
HL650_RS21930	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HL650_RS21940	ENOG4105VRS	hydrolase family 18
HL650_RS21965	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
HL650_RS21970	ENOG41067QW	Transcriptional regulator
HL650_RS21985	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HL650_RS21995	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
HL650_RS22000	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
HL650_RS22005	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
HL650_RS22010	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
HL650_RS22025	ENOG4105C98	muts2 protein
HL650_RS22040	ENOG4108VAC	response regulator
HL650_RS22055	ENOG4105GR3	Histidine kinase
HL650_RS22060	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
HL650_RS22090	ENOG4108UW5	maltose o-acetyltransferase
HL650_RS22095	ENOG4105UQX	Mate efflux family protein
HL650_RS22100	ENOG4108MCI	Transcriptional regulator, ARAC family
HL650_RS22120	ENOG4107R1S	catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine
HL650_RS22125	ENOG4105CQ4	Transcriptional regulator
HL650_RS22130	ENOG4105CNT	hydrolase family 2
HL650_RS22140	ENOG4105DRS	transport system, permease
HL650_RS22145	ENOG4108JE9	extracellular solute-binding protein family 1
HL650_RS22150	ENOG4105UQX	Mate efflux family protein
HL650_RS22165	ENOG4105CQ4	Transcriptional regulator
HL650_RS22190	ENOG4105VMP	Transcriptional regulator
HL650_RS22200	ENOG4108KXV	response regulator
HL650_RS22210	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HL650_RS22225	ENOG4108AEY	RNA polymerase sigma factor
HL650_RS22235	ENOG4105DR6	Trap dicarboxylate transporter, dctp subunit
HL650_RS22240	ENOG410835K	Tripartite ATP-Independent Periplasmic transporter DctQ
HL650_RS22245	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
HL650_RS22250	ENOG4105CV1	Transketolase (EC 2.2.1.1)
HL650_RS22255	ENOG4108IUS	Transketolase
HL650_RS22260	ENOG4105CHR	reductase
HL650_RS22295	ENOG4105CK3	Lysine 2,3-aminomutase YodO family protein
HL650_RS22310	ENOG4105EJ7	Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity)
HL650_RS22325	ENOG4105D22	carbon starvation protein
HL650_RS22330	ENOG4107HQ7	repeat protein
HL650_RS22335	ENOG41063TF	transcriptional regulator (AraC
HL650_RS22390	ENOG4105CKM	Branched-chain carboxylic acid kinase
HL650_RS22405	ENOG4108VB1	regulatoR
HL650_RS22410	ENOG4105C2F	Histidine kinase
HL650_RS22430	ENOG4105F66	Binding-protein-dependent transport systems inner membrane component
HL650_RS22440	ENOG4105I8F	Histidine kinase
HL650_RS22455	ENOG4105HDK	L-asparaginase
HL650_RS22470	ENOG41062D9	Histidine kinase
HL650_RS22480	ENOG4105C4H	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity)
HL650_RS22490	ENOG4105XT2	Transcriptional regulator
HL650_RS22510	ENOG4108R6W	Transcriptional regulator, ARAC family
HL650_RS22515	ENOG4105CPF	Cell wall formation (By similarity)
HL650_RS22520	ENOG4107EES	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity)
HL650_RS22525	ENOG4105VTR	Integrase
HL650_RS22540	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
HL650_RS22545	ENOG4105D3Q	Sugar transferase
HL650_RS22550	ENOG4108RTV	Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity)
HL650_RS22560	ENOG4105CPF	Cell wall formation (By similarity)
HL650_RS22575	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
HL650_RS22580	ENOG4108UW5	maltose o-acetyltransferase
HL650_RS22655	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
HL650_RS22665	ENOG4105FB9	CRISPR-associated protein
HL650_RS22685	ENOG4105DYN	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity)
HL650_RS22690	ENOG4105KCF	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity)
HL650_RS22695	ENOG4107QJQ	Mate efflux family protein
HL650_RS22700	ENOG4105E9Q	Acyl-transferase
HL650_RS22705	ENOG4105UQX	Mate efflux family protein
HL650_RS22720	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
HL650_RS22725	ENOG4105DRR	Transcriptional regulator, GntR family
HL650_RS22730	ENOG4105E1K	spore germination protein
HL650_RS22740	ENOG4108ZXQ	stage ii sporulation protein r
HL650_RS22745	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
HL650_RS22760	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
HL650_RS22765	ENOG4107RVG	penicillin-binding protein
HL650_RS22800	ENOG4105C2F	Histidine kinase
HL650_RS22805	ENOG4105EQD	regulatoR
HL650_RS22815	ENOG4105DB9	Binding-protein-dependent transport systems inner membrane component
HL650_RS22820	ENOG4105DRS	transport system, permease
HL650_RS22825	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
HL650_RS22865	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
HL650_RS22885	ENOG4105CNB	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
HL650_RS22890	ENOG4105CNB	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
HL650_RS22895	ENOG4105K4W	Could be involved in septation (By similarity)
HL650_RS22915	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
HL650_RS22920	ENOG4105CQ4	Transcriptional regulator
HL650_RS22955	ENOG4108Z6B	deaminase
HL650_RS22965	ENOG4107T5V	SNARE associated Golgi
HL650_RS22980	ENOG4105CTQ	phosphohexokinase
HL650_RS22985	ENOG4105C6E	dna polymerase iii
HL650_RS22990	ENOG410816I	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
HL650_RS22995	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
HL650_RS23000	ENOG4105ETE	Transcriptional regulator (LacI family
HL650_RS23010	ENOG4105CV1	Transketolase (EC 2.2.1.1)
HL650_RS23015	ENOG4108IUS	Transketolase
HL650_RS23025	ENOG4108ZDA	Sporulation protein YyaC
HL650_RS23045	ENOG4105ETE	Transcriptional regulator (LacI family
HL650_RS23125	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
HL650_RS23130	ENOG4105I8F	Histidine kinase
HL650_RS23150	ENOG4105CVN	desaturase
HL650_RS23170	ENOG4107SHJ	sulfite reductase subunit b
HL650_RS23185	ENOG4106DSS	Tartrate dehydratase subunit alpha
HL650_RS23215	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
HL650_RS23335	ENOG4105E4I	Glycoside hydrolase family 28
HL650_RS23350	ENOG4105HFT	AraC family transcriptional regulator
HL650_RS23360	ENOG4108HRK	Histidine kinase
HL650_RS23365	ENOG4105EQD	regulatoR
HL650_RS23385	ENOG4105DRS	transport system, permease
HL650_RS23455	ENOG4107VGF	ig domain protein group 2 domain protein
HL650_RS23470	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HL650_RS23475	ENOG4105GQU	Trap dicarboxylate transporter, dctp subunit
HL650_RS23485	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
HL650_RS23490	ENOG4105CPN	adenine deaminase
HL650_RS23495	ENOG4105C0A	alcohol dehydrogenase
HL650_RS23500	ENOG4105CEZ	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity)
HL650_RS23505	ENOG4107S2N	Type III effector Hrp-dependent
HL650_RS23555	ENOG4105W5Q	DNA repair protein (RadC
HL650_RS23580	ENOG4105K4H	Nlp p60 protein
HL650_RS23630	ENOG4108Q9H	CobQ/CobB/MinD/ParA nucleotide binding domain
HL650_RS23665	ENOG4105CPQ	Dehydrogenase
HL650_RS23690	ENOG4105BZU	Histidine kinase
HL650_RS23700	ENOG4105BZU	Histidine kinase
HL650_RS23715	ENOG4105DEI	Mannitol dehydrogenase
HL650_RS23720	ENOG4105CHZ	Catalyzes the dehydration of D-mannonate (By similarity)
HL650_RS23725	ENOG41086D8	Transcriptional regulator
HL650_RS23740	ENOG4105DUM	transcriptional regulator, lysR family
HL650_RS23745	ENOG4105HMI	Membrane
HL650_RS23755	ENOG4107YEV	ferritin
HL650_RS23765	ENOG4107UH8	sugar kinase
HL650_RS23785	ENOG4105ECB	domain protein
HL650_RS23810	ENOG4108Z4T	Peptidase M50
HL650_RS23815	ENOG4105CYW	agmatinase
HL650_RS23825	ENOG4105ERH	Fumarylacetoacetate hydrolase
HL650_RS23855	ENOG4105CUK	Alpha-N-arabinofuranosidase (EC 3.2.1.55)
HL650_RS23865	ENOG4105CZZ	Alpha-N-arabinofuranosidase (EC 3.2.1.55)
HL650_RS23875	ENOG4108JE9	extracellular solute-binding protein family 1
HL650_RS23885	ENOG4105DRS	transport system, permease
HL650_RS23900	ENOG4105CU9	asparagine synthetase A
HL650_RS23905	ENOG4105DTC	1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (air) carboxylase
HL650_RS23915	ENOG4105C3S	Mate efflux family protein
HL650_RS23930	ENOG4105C7W	Xanthine dehydrogenase
HL650_RS23935	ENOG4105E5D	amino acid
HL650_RS23940	ENOG4105DFM	M18 family aminopeptidase
HL650_RS23975	ENOG4105CUB	amino acid
HL650_RS23985	ENOG4105DZS	Phenylacetate-CoA ligase
HL650_RS23990	ENOG4105QA4	4Fe-4S Ferredoxin, iron-sulfur binding domain protein
HL650_RS24010	ENOG4105K4H	Nlp p60 protein
HL650_RS24025	ENOG4105CNW	domain protein
HL650_RS24030	ENOG4105CJQ	hydrolase, family 31
HL650_RS24055	ENOG4105C50	Binding-protein-dependent transport systems, inner membrane component
HL650_RS24065	ENOG4105EQD	regulatoR
HL650_RS24075	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
HL650_RS24100	ENOG4105C50	Binding-protein-dependent transport systems, inner membrane component
HL650_RS24105	ENOG4108HRK	Histidine kinase
HL650_RS24110	ENOG4107XVH	Transcriptional regulator
HL650_RS24115	ENOG4107QK4	glycoside hydrolase, family 3 domain protein
HL650_RS24125	ENOG4105DA6	Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity)
HL650_RS24130	ENOG4105F4C	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity)
HL650_RS24155	ENOG4105ETE	Transcriptional regulator (LacI family
HL650_RS24185	ENOG410667J	hydrolase
HL650_RS24190	ENOG4105C5N	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
HL650_RS24205	ENOG4105BZG	amino acid carrier protein
HL650_RS24215	ENOG4105CEQ	signal transduction histidine kinase regulating citrate malate metabolism
HL650_RS24225	ENOG4105BZ1	(ABC) transporter
HL650_RS24250	ENOG41067S9	phage shock protein C, PspC
HL650_RS24255	ENOG4105K4I	Scp-like extracellular
HL650_RS24265	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
HL650_RS24290	ENOG41082AN	stage II sporulation protein
HL650_RS24300	ENOG4105CT2	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HL650_RS24315	ENOG4105D29	Helix-turn-helix type 11 domain protein
HL650_RS24345	ENOG4105C2F	Histidine kinase
HL650_RS24350	ENOG4105EQD	regulatoR
HL650_RS24360	ENOG4105EQD	regulatoR
HL650_RS24365	ENOG4105C2F	Histidine kinase
HL650_RS24380	ENOG4105DCG	PHP domain protein
HL650_RS24400	ENOG4105C50	Binding-protein-dependent transport systems, inner membrane component
HL650_RS24405	ENOG4108RVA	ribokinase
HL650_RS24410	ENOG4105F8D	glycoside hydrolase family 4
HL650_RS24420	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
HL650_RS24440	ENOG4105C50	Binding-protein-dependent transport systems, inner membrane component
HL650_RS24455	ENOG4105CNT	hydrolase family 2
HL650_RS24465	ENOG41090VF	Stage v sporulation protein ac
HL650_RS24480	ENOG4105CUZ	uba thif-type nad fad binding protein
HL650_RS24495	ENOG4105CIE	May be required for sporulation (By similarity)
HL650_RS24500	ENOG4105KRI	phosphocarrier protein (HPr
HL650_RS24510	ENOG4105CAC	Catalyzes the conversion of L-arabinose to L-ribulose (By similarity)
HL650_RS24525	ENOG4105C2F	Histidine kinase
HL650_RS24540	ENOG4108JE9	extracellular solute-binding protein family 1
HL650_RS24555	ENOG4105C8I	hydrolase, family 38
HL650_RS24560	ENOG4105DFM	M18 family aminopeptidase
HL650_RS24575	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
HL650_RS24580	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
HL650_RS24595	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HL650_RS24605	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
HL650_RS24615	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
HL650_RS24620	ENOG41082SA	50s ribosomal protein l29
HL650_RS24625	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
HL650_RS24645	ENOG41082QR	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
HL650_RS24650	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
HL650_RS24655	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
HL650_RS24675	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
HL650_RS24685	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
HL650_RS24700	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
HL650_RS24705	ENOG41067V7	50S ribosomal protein L36
HL650_RS24710	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HL650_RS24715	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
HL650_RS24720	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
HL650_RS24730	ENOG4108ZT0	50S ribosomal protein l17
HL650_RS24735	ENOG4107TE5	Lipid kinase
HL650_RS24760	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
HL650_RS24765	ENOG4105C8Q	Methyl-accepting chemotaxis
HL650_RS24775	ENOG4105C8Q	Methyl-accepting chemotaxis
HL650_RS24815	ENOG4108IXP	Carbohydrate diacid transcriptional activator CdaR
HL650_RS24820	ENOG4105CAK	Cell division ATP-binding protein ftsE
HL650_RS24825	ENOG4105CRP	Part of the ABC transporter FtsEX involved in
HL650_RS24830	ENOG4105CN1	protease
HL650_RS24840	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
HL650_RS24845	ENOG4107XVH	Transcriptional regulator
HL650_RS24850	ENOG4105DET	Rhamnulokinase
HL650_RS24855	ENOG4105DKG	l-rhamnose isomerase
HL650_RS24860	ENOG4105C9J	Catalyzes the reversible cleavage of L-rhamnulose-1- phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde (By similarity)
HL650_RS24870	ENOG4105CJK	Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity)
HL650_RS24875	ENOG4105CIB	oxidoreductase Domain protein
HL650_RS24890	ENOG4105BZU	Histidine kinase
HL650_RS25010	ENOG4107S6Z	Na H antiporter
HL650_RS25020	ENOG4105CI8	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity)
HL650_RS25025	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HL650_RS25030	ENOG4105CFG	Acts as a chaperone (By similarity)
HL650_RS25035	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HL650_RS25080	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
HL650_RS25085	ENOG4107TVK	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)
HL650_RS25090	ENOG4107QI6	Cysteine desulfurase
HL650_RS25095	ENOG4105D8I	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity)
HL650_RS25105	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
HL650_RS25110	ENOG4105VBH	UPF0297 protein
HL650_RS25125	ENOG4105CN5	Metallo-Beta-Lactamase
HL650_RS25145	ENOG4105CFP	Peptidase U32
HL650_RS25150	ENOG4105DMD	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HL650_RS25160	ENOG4108W3Q	Transcriptional regulator
HL650_RS25165	ENOG4105C0P	Mg chelatase subunit ChlI
HL650_RS25170	ENOG4105C79	DNA protecting protein DprA
HL650_RS25175	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
HL650_RS25180	ENOG4105EUM	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor (By similarity)
HL650_RS25185	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
HL650_RS25190	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
HL650_RS25200	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
HL650_RS25215	ENOG4105EQD	regulatoR
HL650_RS25250	ENOG4105CJQ	hydrolase, family 31
HL650_RS25260	ENOG4105CZV	ABC transporter
HL650_RS25265	ENOG4105W8V	TRANSCRIPTIONAl REGULATOR GntR family
HL650_RS25270	ENOG4108RCM	Nitroreductase
HL650_RS25275	ENOG4108VP3	Lysine exporter protein (LysE YggA)
HL650_RS25305	ENOG4105X0R	protein from nitrogen regulatory protein P-II
HL650_RS25310	ENOG4108UQV	Membrane
HL650_RS25330	ENOG4105DIH	basic membrane
HL650_RS25335	ENOG4108JQ9	ABC transporter
HL650_RS25340	ENOG4105UIB	(ABC) transporter
HL650_RS25345	ENOG41080EB	ABC transporter, permease
HL650_RS25360	ENOG4105C8J	)-transporter
HL650_RS25380	ENOG4105CM2	brancheD-chain amino acid aminotransferase
HL650_RS25390	ENOG4105CDW	Resistance protein
HL650_RS25405	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
HL650_RS25410	ENOG4105EUJ	GTP cyclohydrolase i
HL650_RS25415	ENOG4105KFW	domain protein
HL650_RS25420	ENOG4105EEI	dihydropteroate synthase
HL650_RS25425	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HL650_RS25430	ENOG4107QZB	decarboxylase
HL650_RS25450	ENOG4105C8V	SAICAR synthetase
HL650_RS25455	ENOG4106IQC	argininosuccinate lyase
HL650_RS25470	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
HL650_RS25490	ENOG4105C84	Histidine ammonia-lyase
HL650_RS25495	ENOG4105C94	Transporter
HL650_RS25505	ENOG4105VSY	K01512 acylphosphatase EC 3.6.1.7
HL650_RS25525	ENOG4105C5I	Dehydrogenase
HL650_RS25550	ENOG4105D2N	Aldolase
HL650_RS25560	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
HL650_RS25570	ENOG4107RJ5	oxidoreductase
HL650_RS25575	ENOG4105F0H	myo-inositol catabolism protein
HL650_RS25580	ENOG4107QP6	Xylose isomerase domain protein TIM barrel
HL650_RS25590	ENOG4105D4X	repressor
HL650_RS25595	ENOG4105EQD	regulatoR
HL650_RS25600	ENOG4105C2F	Histidine kinase
HL650_RS25630	ENOG4105EQD	regulatoR
HL650_RS25635	ENOG4105ETE	Transcriptional regulator (LacI family
HL650_RS25645	ENOG4105F0P	binding-protein-dependent transport systems inner membrane Component
HL650_RS25650	ENOG4105F66	Binding-protein-dependent transport systems inner membrane component
HL650_RS25655	ENOG4105DSG	hydrolase family 43
HL650_RS25660	ENOG4105CB5	ATP-dependent DNA helicase recG
HL650_RS25680	ENOG4105EQD	regulatoR
HL650_RS25700	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
HL650_RS25725	ENOG4105C8J	)-transporter
HL650_RS25750	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
HL650_RS25760	ENOG4108ZJ4	polysaccharide deacetylase
HL650_RS25765	ENOG4105D1H	recombination factor protein RarA
HL650_RS25775	ENOG4105N5T	Radical SAM Protein
HL650_RS25800	ENOG4105DCG	PHP domain protein
HL650_RS25805	ENOG4105KGF	protein, YerC YecD
HL650_RS25830	ENOG41062JF	Transcriptional regulator
HL650_RS25835	ENOG41067QW	Transcriptional regulator
HL650_RS25865	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
HL650_RS25905	ENOG4107QUV	Domain protein
HL650_RS25950	ENOG4105XB7	anti-repressor protein
HL650_RS25990	ENOG4107Y5K	Resolvase
HL650_RS26020	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
HL650_RS26040	ENOG4108IUW	ABC transporter
HL650_RS26075	ENOG4107R73	Mate efflux family protein
HL650_RS26090	ENOG4105C1J	atp-dependent rna helicase
HL650_RS26100	ENOG4108MCI	Transcriptional regulator, ARAC family
HL650_RS26105	ENOG4108UW5	maltose o-acetyltransferase
HL650_RS26110	ENOG4107QMU	Mate efflux family protein
HL650_RS26120	ENOG4105C6Z	Gluconate
HL650_RS26125	ENOG4105CPQ	Dehydrogenase