locus-tag	class	description
HL650_RS00005	COG0246	Mannitol dehydrogenase
HL650_RS00010	COG2721	sulfolactate sulfo-lyase activity
HL650_RS00035	COG3835	regulator
HL650_RS00040	COG1929	Belongs to the glycerate kinase type-1 family
HL650_RS00110	COG2207	Transcriptional regulator
HL650_RS00110	COG0662	Cupin 2, conserved barrel domain protein
HL650_RS00115	COG1653	transport
HL650_RS00125	COG0395	ABC-type sugar transport system, permease component
HL650_RS00130	COG0673	inositol 2-dehydrogenase activity
HL650_RS00135	COG4409	exo-alpha-(2->6)-sialidase activity
HL650_RS00150	COG0673	inositol 2-dehydrogenase activity
HL650_RS00155	COG3622	Belongs to the hyi family
HL650_RS00160	COG2211	Major facilitator Superfamily
HL650_RS00165	COG0789	Transcriptional regulator
HL650_RS00175	COG1309	transcriptional regulator
HL650_RS00195	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HL650_RS00200	COG1022	Amp-dependent synthetase and ligase
HL650_RS00205	COG1917	Cupin 2, conserved barrel domain protein
HL650_RS00205	COG2207	Transcriptional regulator
HL650_RS00210	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
HL650_RS00215	COG1070	Carbohydrate kinase
HL650_RS00220	COG0235	Class ii aldolase
HL650_RS00225	COG4154	Belongs to the RbsD FucU family
HL650_RS00230	COG1720	tRNA m6t6A37 methyltransferase activity
HL650_RS00235	COG0789	Transcriptional regulator
HL650_RS00235	COG4978	Transcriptional regulator
HL650_RS00275	COG1028	Short-chain dehydrogenase reductase Sdr
HL650_RS00310	COG3706	GGDEF domain
HL650_RS00315	COG1940	carbohydrate kinase activity
HL650_RS00320	COG1063	alcohol dehydrogenase
HL650_RS00345	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HL650_RS00350	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HL650_RS00360	COG1316	TRANSCRIPTIONal
HL650_RS00370	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HL650_RS00375	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HL650_RS00380	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HL650_RS00395	COG0254	rRNA binding
HL650_RS00400	COG3872	metal-dependent enzyme
HL650_RS00405	COG2890	protein-(glutamine-N5) methyltransferase activity
HL650_RS00410	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HL650_RS00430	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HL650_RS00440	COG0582	viral genome integration into host DNA
HL650_RS00470	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HL650_RS00475	COG1328	CTP reductase activity
HL650_RS00475	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HL650_RS00490	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HL650_RS00495	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HL650_RS00500	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HL650_RS00505	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HL650_RS00530	COG1028	Short-chain dehydrogenase reductase Sdr
HL650_RS00540	COG2221	Nitrite and sulphite reductase 4Fe-4S
HL650_RS00550	COG4862	establishment of competence for transformation
HL650_RS00570	COG5001	Diguanylate cyclase
HL650_RS00575	COG0860	N-Acetylmuramoyl-L-alanine amidase
HL650_RS00580	COG0009	L-threonylcarbamoyladenylate synthase
HL650_RS00585	COG0698	ribose 5-phosphate isomerase
HL650_RS00600	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HL650_RS00605	COG0617	tRNA 3'-terminal CCA addition
HL650_RS00615	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HL650_RS00625	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HL650_RS00650	COG0037	tRNA processing
HL650_RS00660	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HL650_RS00675	COG0745	RESPONSE REGULATOR receiver
HL650_RS00690	COG3344	reverse transcriptase
HL650_RS00710	COG3708	Transcriptional regulator
HL650_RS00710	COG2207	Transcriptional regulator
HL650_RS00740	COG0242	peptide deformylase activity
HL650_RS00745	COG0242	peptide deformylase activity
HL650_RS00760	COG0440	acetolactate synthase activity
HL650_RS00765	COG0028	Belongs to the TPP enzyme family
HL650_RS00770	COG2315	Protein conserved in bacteria
HL650_RS00775	COG1592	Rubrerythrin
HL650_RS00790	COG0723	plastoquinol--plastocyanin reductase activity
HL650_RS00790	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HL650_RS00810	COG0519	Catalyzes the synthesis of GMP from XMP
HL650_RS00845	COG0138	bifunctional purine biosynthesis protein purh
HL650_RS00850	COG1063	alcohol dehydrogenase
HL650_RS00860	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HL650_RS00870	COG0733	neurotransmitter:sodium symporter activity
HL650_RS00880	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HL650_RS00900	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HL650_RS00910	COG0708	Exodeoxyribonuclease III
HL650_RS00920	COG1104	cysteine desulfurase activity
HL650_RS00925	COG1408	metallophosphoesterase
HL650_RS00930	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HL650_RS00950	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HL650_RS00960	COG1937	Protein conserved in bacteria
HL650_RS00975	COG1199	ATP-dependent helicase activity
HL650_RS00975	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HL650_RS00985	COG0251	oxidation-reduction process
HL650_RS00990	COG2226	methyltransferase
HL650_RS00995	COG2226	methyltransferase
HL650_RS01000	COG0601	transmembrane transport
HL650_RS01015	COG0444	Belongs to the ABC transporter superfamily
HL650_RS01020	COG4608	Belongs to the ABC transporter superfamily
HL650_RS01025	COG0583	DNA-binding transcription factor activity
HL650_RS01035	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HL650_RS01045	COG3835	regulator
HL650_RS01050	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HL650_RS01060	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HL650_RS01070	COG1473	amidohydrolase
HL650_RS01075	COG1653	transport
HL650_RS01080	COG2972	Histidine kinase
HL650_RS01085	COG4753	response regulator
HL650_RS01085	COG2207	Transcriptional regulator
HL650_RS01115	COG0601	transmembrane transport
HL650_RS01125	COG0577	efflux transmembrane transporter activity
HL650_RS01125	COG1136	(ABC) transporter
HL650_RS01150	COG1414	Transcriptional regulator
HL650_RS01155	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HL650_RS01165	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HL650_RS01170	COG0674	pyruvate-flavodoxin oxidoreductase activity
HL650_RS01170	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HL650_RS01245	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HL650_RS01250	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HL650_RS01255	COG1120	ATPase activity
HL650_RS01315	COG1609	Transcriptional regulator
HL650_RS01320	COG1069	ribulokinase activity
HL650_RS01345	COG3708	Transcriptional regulator
HL650_RS01345	COG2207	Transcriptional regulator
HL650_RS01375	COG1937	Protein conserved in bacteria
HL650_RS01385	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HL650_RS01390	COG0488	(ABC) transporter
HL650_RS01395	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HL650_RS01405	COG3706	GGDEF domain
HL650_RS01410	COG1045	serine acetyltransferase
HL650_RS01415	COG0215	cysteine-tRNA ligase activity
HL650_RS01425	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HL650_RS01435	COG2972	Histidine kinase
HL650_RS01440	COG4753	response regulator
HL650_RS01440	COG2207	Transcriptional regulator
HL650_RS01450	COG4209	transmembrane transport
HL650_RS01455	COG0395	ABC-type sugar transport system, permease component
HL650_RS01465	COG1253	flavin adenine dinucleotide binding
HL650_RS01470	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HL650_RS01500	COG3620	sequence-specific DNA binding
HL650_RS01600	COG0740	serine-type endopeptidase activity
HL650_RS01720	COG2186	Transcriptional regulator
HL650_RS01725	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HL650_RS01730	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HL650_RS01740	COG3959	Transketolase, thiamine diphosphate binding domain
HL650_RS01745	COG3958	Transketolase
HL650_RS01750	COG0287	Prephenate dehydrogenase
HL650_RS01755	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HL650_RS01760	COG0549	Belongs to the carbamate kinase family
HL650_RS01765	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HL650_RS01770	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HL650_RS01800	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HL650_RS01800	COG0425	Belongs to the sulfur carrier protein TusA family
HL650_RS01805	COG3608	succinylglutamate desuccinylase aspartoacylase
HL650_RS01805	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HL650_RS01810	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HL650_RS01820	COG5002	protein histidine kinase activity
HL650_RS01820	COG5001	Diguanylate cyclase
HL650_RS01825	COG1854	S-ribosylhomocysteine lyase activity
HL650_RS01835	COG0745	RESPONSE REGULATOR receiver
HL650_RS01845	COG1175	transmembrane transport
HL650_RS01850	COG0395	ABC-type sugar transport system, permease component
HL650_RS01890	COG0564	pseudouridine synthase activity
HL650_RS01895	COG1177	transmembrane transport
HL650_RS01900	COG1176	ABC-type spermidine putrescine transport system, permease component I
HL650_RS01905	COG3842	ATPase activity
HL650_RS01930	COG2207	Transcriptional regulator
HL650_RS01930	COG4753	response regulator
HL650_RS01935	COG2972	Histidine kinase
HL650_RS01945	COG1175	transmembrane transport
HL650_RS01950	COG0395	ABC-type sugar transport system, permease component
HL650_RS01980	COG0641	radical SAM
HL650_RS01985	COG2972	Histidine kinase
HL650_RS01990	COG3279	Response regulator of the LytR AlgR family
HL650_RS02000	COG1175	transmembrane transport
HL650_RS02005	COG0395	ABC-type sugar transport system, permease component
HL650_RS02010	COG3119	arylsulfatase activity
HL650_RS02070	COG2205	protein histidine kinase activity
HL650_RS02085	COG1131	(ABC) transporter
HL650_RS02090	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HL650_RS02100	COG1881	PFAM PEBP family protein
HL650_RS02155	COG0840	transmembrane signaling receptor activity
HL650_RS02160	COG2205	protein histidine kinase activity
HL650_RS02160	COG2198	Histidine kinase
HL650_RS02160	COG0784	Response regulator, receiver
HL650_RS02165	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HL650_RS02170	COG1012	belongs to the aldehyde dehydrogenase family
HL650_RS02175	COG1757	Na H antiporter
HL650_RS02180	COG0038	chloride channel
HL650_RS02210	COG2084	Dehydrogenase
HL650_RS02225	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HL650_RS02230	COG1979	alcohol dehydrogenase
HL650_RS02235	COG3681	Belongs to the UPF0597 family
HL650_RS02245	COG1175	transmembrane transport
HL650_RS02250	COG0395	ABC-type sugar transport system, permease component
HL650_RS02260	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HL650_RS02300	COG4667	esterase of the alpha-beta hydrolase superfamily
HL650_RS02310	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HL650_RS02315	COG2972	Histidine kinase
HL650_RS02325	COG1175	transmembrane transport
HL650_RS02330	COG0395	ABC-type sugar transport system, permease component
HL650_RS02335	COG4753	response regulator
HL650_RS02335	COG2207	Transcriptional regulator
HL650_RS02345	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HL650_RS02365	COG0613	PHP domain protein
HL650_RS02370	COG0534	Mate efflux family protein
HL650_RS02395	COG2508	Transcriptional regulator
HL650_RS02410	COG0471	metal ion transport
HL650_RS02410	COG3273	potassium ion transport
HL650_RS02425	COG5598	trimethylamine methyltransferase
HL650_RS02460	COG0446	pyridine nucleotide-disulphide oxidoreductase
HL650_RS02460	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HL650_RS02465	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HL650_RS02485	COG1027	Aspartate ammonia-lyase
HL650_RS02490	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HL650_RS02500	COG1027	Aspartate ammonia-lyase
HL650_RS02505	COG0281	malic enzyme
HL650_RS02515	COG2414	aldehyde ferredoxin oxidoreductase
HL650_RS02520	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HL650_RS02525	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HL650_RS02530	COG0303	'Molybdopterin
HL650_RS02535	COG0671	phosphoesterase, PA-phosphatase related
HL650_RS02540	COG0561	phosphatase activity
HL650_RS02545	COG0187	DNA topoisomerase II activity
HL650_RS02550	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HL650_RS02555	COG0598	Magnesium transport protein CorA
HL650_RS02570	COG0195	Participates in both transcription termination and antitermination
HL650_RS02575	COG2740	Nucleic-acid-binding protein implicated in transcription termination
HL650_RS02585	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HL650_RS02590	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HL650_RS02595	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HL650_RS02600	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HL650_RS02605	COG0196	riboflavin kinase activity
HL650_RS02610	COG0704	Plays a role in the regulation of phosphate uptake
HL650_RS02615	COG0791	NLP P60 protein
HL650_RS02620	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HL650_RS02625	COG1185	polyribonucleotide nucleotidyltransferase activity
HL650_RS02630	COG0602	queuosine metabolic process
HL650_RS02635	COG0756	dUTP diphosphatase activity
HL650_RS02645	COG1309	transcriptional regulator
HL650_RS02650	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HL650_RS02680	COG1523	belongs to the glycosyl hydrolase 13 family
HL650_RS02695	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HL650_RS02700	COG4894	glucomannan catabolic process
HL650_RS02715	COG2721	sulfolactate sulfo-lyase activity
HL650_RS02720	COG1609	Transcriptional regulator
HL650_RS02740	COG1904	glucuronate isomerase
HL650_RS02745	COG2233	PERMEase
HL650_RS02770	COG0745	RESPONSE REGULATOR receiver
HL650_RS02805	COG1959	2 iron, 2 sulfur cluster binding
HL650_RS02840	COG1757	Na H antiporter
HL650_RS02845	COG5426	von Willebrand factor, type A
HL650_RS02890	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HL650_RS02895	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HL650_RS02900	COG0577	efflux transmembrane transporter activity
HL650_RS02900	COG1136	(ABC) transporter
HL650_RS02915	COG1309	transcriptional regulator
HL650_RS02990	COG3279	Response regulator of the LytR AlgR family
HL650_RS03015	COG1309	transcriptional regulator
HL650_RS03030	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HL650_RS03045	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HL650_RS03055	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HL650_RS03060	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HL650_RS03080	COG0674	pyruvate-flavodoxin oxidoreductase activity
HL650_RS03090	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
HL650_RS03095	COG1940	carbohydrate kinase activity
HL650_RS03145	COG3655	Transcriptional regulator
HL650_RS03155	COG0510	thiamine kinase activity
HL650_RS03165	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HL650_RS03195	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HL650_RS03215	COG0544	peptidyl-prolyl cis-trans isomerase activity
HL650_RS03230	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HL650_RS03235	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HL650_RS03240	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HL650_RS03245	COG1122	ATPase activity
HL650_RS03255	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HL650_RS03285	COG3706	GGDEF domain
HL650_RS03290	COG1278	Cold shock
HL650_RS03295	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HL650_RS03300	COG0284	orotidine-5'-phosphate decarboxylase activity
HL650_RS03310	COG0167	dihydroorotate dehydrogenase activity
HL650_RS03315	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HL650_RS03345	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HL650_RS03350	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HL650_RS03355	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HL650_RS03360	COG0151	Belongs to the GarS family
HL650_RS03370	COG0542	response to heat
HL650_RS03380	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HL650_RS03415	COG0739	heme binding
HL650_RS03415	COG0741	lytic transglycosylase activity
HL650_RS03415	COG1196	nuclear chromosome segregation
HL650_RS03435	COG1288	antiporter activity
HL650_RS03440	COG1473	amidohydrolase
HL650_RS03495	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
HL650_RS03520	COG0647	UMP catabolic process
HL650_RS03530	COG1194	a g-specific adenine glycosylase
HL650_RS03535	COG1216	Glycosyl transferase, family 2
HL650_RS03540	COG0583	DNA-binding transcription factor activity
HL650_RS03585	COG1979	alcohol dehydrogenase
HL650_RS03590	COG0534	Mate efflux family protein
HL650_RS03595	COG0745	RESPONSE REGULATOR receiver
HL650_RS03620	COG0584	glycerophosphoryl diester phosphodiesterase
HL650_RS03625	COG1597	lipid kinase activity
HL650_RS03630	COG1803	Methylglyoxal synthase
HL650_RS03640	COG0534	Mate efflux family protein
HL650_RS03650	COG2357	RelA SpoT domain protein
HL650_RS03660	COG0484	heat shock protein binding
HL650_RS03670	COG3681	Belongs to the UPF0597 family
HL650_RS03675	COG4399	Belongs to the UPF0754 family
HL650_RS03690	COG2964	Protein conserved in bacteria
HL650_RS03695	COG0251	oxidation-reduction process
HL650_RS03705	COG1757	Na H antiporter
HL650_RS03755	COG1309	transcriptional regulator
HL650_RS03760	COG1136	(ABC) transporter
HL650_RS03765	COG0577	efflux transmembrane transporter activity
HL650_RS03785	COG1247	-acetyltransferase
HL650_RS03800	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
HL650_RS03800	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
HL650_RS03825	COG2986	histidine ammonia-lyase
HL650_RS03855	COG0242	peptide deformylase activity
HL650_RS03860	COG2207	Transcriptional regulator
HL650_RS03865	COG1653	transport
HL650_RS03870	COG1175	transmembrane transport
HL650_RS03880	COG2205	protein histidine kinase activity
HL650_RS03885	COG0745	RESPONSE REGULATOR receiver
HL650_RS03900	COG1131	(ABC) transporter
HL650_RS03905	COG0488	(ABC) transporter
HL650_RS03920	COG1115	amino acid carrier protein
HL650_RS03935	COG0251	oxidation-reduction process
HL650_RS03940	COG5598	trimethylamine methyltransferase
HL650_RS03960	COG2986	histidine ammonia-lyase
HL650_RS03990	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HL650_RS03995	COG2986	histidine ammonia-lyase
HL650_RS04000	COG2207	Transcriptional regulator
HL650_RS04000	COG3708	Transcriptional regulator
HL650_RS04020	COG0693	protein deglycase activity
HL650_RS04025	COG2378	regulation of single-species biofilm formation
HL650_RS04035	COG0492	ferredoxin-NADP+ reductase activity
HL650_RS04050	COG1228	amidohydrolase
HL650_RS04060	COG3404	Formiminotransferase-cyclodeaminase
HL650_RS04065	COG3052	prosthetic group binding
HL650_RS04140	COG0460	homoserine dehydrogenase
HL650_RS04150	COG1735	metal-dependent hydrolase with the TIM-barrel fold
HL650_RS04155	COG0488	(ABC) transporter
HL650_RS04165	COG1733	regulation of RNA biosynthetic process
HL650_RS04170	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HL650_RS04175	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HL650_RS04200	COG0747	negative chemotaxis
HL650_RS04215	COG0444	Belongs to the ABC transporter superfamily
HL650_RS04220	COG4608	Belongs to the ABC transporter superfamily
HL650_RS04225	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HL650_RS04235	COG0205	6-phosphofructokinase activity
HL650_RS04250	COG1115	amino acid carrier protein
HL650_RS04260	COG1653	transport
HL650_RS04265	COG1175	transmembrane transport
HL650_RS04270	COG0395	ABC-type sugar transport system, permease component
HL650_RS04275	COG3250	beta-galactosidase activity
HL650_RS04285	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
HL650_RS04290	COG0295	cytidine deaminase activity
HL650_RS04300	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HL650_RS04310	COG0534	Mate efflux family protein
HL650_RS04315	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
HL650_RS04325	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HL650_RS04330	COG2200	EAL domain
HL650_RS04340	COG0402	S-adenosylhomocysteine deaminase activity
HL650_RS04345	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HL650_RS04345	COG0493	'glutamate synthase
HL650_RS04350	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HL650_RS04355	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HL650_RS04365	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HL650_RS04370	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HL650_RS04375	COG1116	anion transmembrane transporter activity
HL650_RS04385	COG0561	phosphatase activity
HL650_RS04395	COG0546	phosphoglycolate phosphatase activity
HL650_RS04400	COG0561	phosphatase activity
HL650_RS04410	COG1012	belongs to the aldehyde dehydrogenase family
HL650_RS04415	COG4106	trans-aconitate 2-methyltransferase activity
HL650_RS04445	COG1136	(ABC) transporter
HL650_RS04450	COG2816	NAD+ diphosphatase activity
HL650_RS04470	COG0534	Mate efflux family protein
HL650_RS04475	COG2388	GCN5-related N-acetyl-transferase
HL650_RS04480	COG3250	beta-galactosidase activity
HL650_RS04485	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HL650_RS04500	COG4536	flavin adenine dinucleotide binding
HL650_RS04525	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HL650_RS04525	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HL650_RS04530	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HL650_RS04530	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HL650_RS04545	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HL650_RS04550	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HL650_RS04555	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HL650_RS04565	COG0124	histidyl-tRNA synthetase
HL650_RS04570	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HL650_RS04585	COG1609	Transcriptional regulator
HL650_RS04605	COG1175	transmembrane transport
HL650_RS04610	COG0395	ABC-type sugar transport system, permease component
HL650_RS04615	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HL650_RS04620	COG0745	RESPONSE REGULATOR receiver
HL650_RS04635	COG0577	efflux transmembrane transporter activity
HL650_RS04645	COG1307	EDD domain protein, DegV family
HL650_RS04655	COG0515	serine threonine protein kinase
HL650_RS04675	COG0052	Belongs to the universal ribosomal protein uS2 family
HL650_RS04680	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HL650_RS04695	COG1733	regulation of RNA biosynthetic process
HL650_RS04710	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
HL650_RS04720	COG4974	Belongs to the 'phage' integrase family
HL650_RS04730	COG1733	regulation of RNA biosynthetic process
HL650_RS04755	COG4129	membrane
HL650_RS04800	COG1131	(ABC) transporter
HL650_RS04810	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HL650_RS04820	COG1131	(ABC) transporter
HL650_RS04830	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HL650_RS04860	COG1032	radical SAM domain protein
HL650_RS04890	COG3507	Belongs to the glycosyl hydrolase 43 family
HL650_RS04905	COG1278	Cold shock
HL650_RS04960	COG1595	DNA-templated transcription, initiation
HL650_RS04970	COG0789	Transcriptional regulator
HL650_RS05015	COG0534	Mate efflux family protein
HL650_RS05060	COG1131	(ABC) transporter
HL650_RS05085	COG2207	Transcriptional regulator
HL650_RS05120	COG0583	DNA-binding transcription factor activity
HL650_RS05125	COG1027	Aspartate ammonia-lyase
HL650_RS05130	COG3588	fructose-bisphosphate aldolase
HL650_RS05145	COG2819	hydrolase of the alpha beta superfamily
HL650_RS05175	COG5001	Diguanylate cyclase
HL650_RS05185	COG0564	pseudouridine synthase activity
HL650_RS05195	COG0583	DNA-binding transcription factor activity
HL650_RS05205	COG1132	(ABC) transporter
HL650_RS05210	COG1132	(ABC) transporter
HL650_RS05240	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HL650_RS05255	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HL650_RS05270	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HL650_RS05285	COG2508	Transcriptional regulator
HL650_RS05290	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HL650_RS05300	COG1393	Belongs to the ArsC family
HL650_RS05305	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HL650_RS05310	COG0488	(ABC) transporter
HL650_RS05325	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HL650_RS05330	COG0352	thiamine-phosphate diphosphorylase activity
HL650_RS05330	COG0351	phosphomethylpyrimidine kinase
HL650_RS05335	COG1882	Formate acetyltransferase
HL650_RS05340	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HL650_RS05355	COG1278	Cold shock
HL650_RS05360	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HL650_RS05365	COG0583	DNA-binding transcription factor activity
HL650_RS05390	COG0494	nUDIX hydrolase
HL650_RS05400	COG3177	Filamentation induced by cAMP protein fic
HL650_RS05415	COG5002	protein histidine kinase activity
HL650_RS05415	COG3850	Histidine kinase
HL650_RS05420	COG1131	(ABC) transporter
HL650_RS05435	COG0745	RESPONSE REGULATOR receiver
HL650_RS05440	COG0745	RESPONSE REGULATOR receiver
HL650_RS05450	COG0653	protein targeting
HL650_RS05470	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HL650_RS05475	COG1917	Cupin 2, conserved barrel domain protein
HL650_RS05475	COG4977	sequence-specific DNA binding
HL650_RS05485	COG2272	Belongs to the type-B carboxylesterase lipase family
HL650_RS05490	COG2211	Major facilitator Superfamily
HL650_RS05500	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HL650_RS05505	COG3118	belongs to the thioredoxin family
HL650_RS05520	COG0356	it plays a direct role in the translocation of protons across the membrane
HL650_RS05540	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HL650_RS05545	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HL650_RS05550	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HL650_RS05555	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HL650_RS05560	COG3250	beta-galactosidase activity
HL650_RS05580	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HL650_RS05585	COG0789	Transcriptional regulator
HL650_RS05590	COG5504	Zn-dependent protease
HL650_RS05600	COG1131	(ABC) transporter
HL650_RS05615	COG0745	RESPONSE REGULATOR receiver
HL650_RS05620	COG5002	protein histidine kinase activity
HL650_RS05670	COG1175	transmembrane transport
HL650_RS05675	COG0395	ABC-type sugar transport system, permease component
HL650_RS05680	COG3842	ATPase activity
HL650_RS05700	COG0259	pyridoxamine-phosphate oxidase activity
HL650_RS05715	COG0110	maltose O-acetyltransferase activity
HL650_RS05735	COG3969	phosphoadenosine phosphosulfate
HL650_RS05740	COG1475	DNA binding
HL650_RS05795	COG1131	(ABC) transporter
HL650_RS05805	COG3620	sequence-specific DNA binding
HL650_RS05815	COG0583	DNA-binding transcription factor activity
HL650_RS05825	COG0601	transmembrane transport
HL650_RS05830	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HL650_RS05835	COG0747	negative chemotaxis
HL650_RS05865	COG0440	acetolactate synthase activity
HL650_RS05870	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HL650_RS05875	COG0583	DNA-binding transcription factor activity
HL650_RS05880	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HL650_RS05885	COG0066	3-isopropylmalate dehydratase activity
HL650_RS05915	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
HL650_RS05950	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HL650_RS05975	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HL650_RS06005	COG2385	sporulation resulting in formation of a cellular spore
HL650_RS06005	COG2247	cell wall binding repeat
HL650_RS06015	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HL650_RS06020	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HL650_RS06020	COG0072	phenylalanine-tRNA ligase activity
HL650_RS06025	COG0406	alpha-ribazole phosphatase activity
HL650_RS06030	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HL650_RS06035	COG2188	Transcriptional regulator
HL650_RS06050	COG2205	protein histidine kinase activity
HL650_RS06050	COG0784	Response regulator, receiver
HL650_RS06055	COG0745	RESPONSE REGULATOR receiver
HL650_RS06115	COG0175	sulfate reduction
HL650_RS06185	COG0681	Belongs to the peptidase S26 family
HL650_RS06195	COG1131	(ABC) transporter
HL650_RS06290	COG3290	protein histidine kinase activity
HL650_RS06380	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HL650_RS06495	COG0328	RNA-DNA hybrid ribonuclease activity
HL650_RS06580	COG0740	serine-type endopeptidase activity
HL650_RS06660	COG4824	toxin secretion phage lysis holin
HL650_RS06670	COG3646	Phage regulatory protein
HL650_RS06690	COG1773	rubredoxin
HL650_RS06690	COG0426	domain, Protein
HL650_RS06710	COG3300	MHYT domain
HL650_RS06710	COG5001	Diguanylate cyclase
HL650_RS06730	COG0784	Response regulator, receiver
HL650_RS06730	COG2205	protein histidine kinase activity
HL650_RS06745	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HL650_RS06760	COG2986	histidine ammonia-lyase
HL650_RS06765	COG4716	Myosin-crossreactive antigen
HL650_RS06785	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HL650_RS06795	COG0495	leucyl-tRNA aminoacylation
HL650_RS06815	COG2201	protein-glutamate methylesterase activity
HL650_RS06825	COG1776	CheC inhibitor of MCP methylation
HL650_RS06830	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
HL650_RS06835	COG2199	diguanylate cyclase activity
HL650_RS06835	COG2203	Gaf domain
HL650_RS06840	COG0643	Histidine kinase
HL650_RS06840	COG2198	Histidine kinase
HL650_RS06855	COG1293	RNA-binding protein homologous to eukaryotic snRNP
HL650_RS06860	COG1561	YicC-like family, N-terminal region
HL650_RS06865	COG2052	Domain of unknown function (DUF370)
HL650_RS06870	COG0194	GDP metabolic process
HL650_RS06875	COG1758	RNA polymerase activity
HL650_RS06880	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HL650_RS06885	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HL650_RS06890	COG1058	Belongs to the CinA family
HL650_RS06890	COG1546	Belongs to the CinA family
HL650_RS06920	COG1404	Belongs to the peptidase S8 family
HL650_RS06925	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HL650_RS06930	COG1802	Transcriptional regulator
HL650_RS06945	COG1131	(ABC) transporter
HL650_RS06955	COG0488	(ABC) transporter
HL650_RS06960	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HL650_RS06965	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HL650_RS06965	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HL650_RS06970	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HL650_RS06975	COG2337	Toxic component of a toxin-antitoxin (TA) module
HL650_RS06985	COG3344	reverse transcriptase
HL650_RS06995	COG1253	flavin adenine dinucleotide binding
HL650_RS07000	COG0217	transcriptional regulatory protein
HL650_RS07005	COG0740	serine-type endopeptidase activity
HL650_RS07010	COG1968	undecaprenyl-diphosphatase activity
HL650_RS07015	COG1674	ftsk spoiiie
HL650_RS07040	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HL650_RS07065	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HL650_RS07110	COG2176	DNA-directed DNA polymerase activity
HL650_RS07135	COG3344	reverse transcriptase
HL650_RS07170	COG1609	Transcriptional regulator
HL650_RS07175	COG2182	Extracellular solute-binding protein
HL650_RS07180	COG1175	transmembrane transport
HL650_RS07185	COG0395	ABC-type sugar transport system, permease component
HL650_RS07190	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
HL650_RS07195	COG2942	2-epimerase
HL650_RS07200	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
HL650_RS07215	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HL650_RS07220	COG1482	cell wall glycoprotein biosynthetic process
HL650_RS07230	COG0583	DNA-binding transcription factor activity
HL650_RS07235	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HL650_RS07255	COG0745	RESPONSE REGULATOR receiver
HL650_RS07280	COG2720	vancomycin resistance protein
HL650_RS07315	COG3706	GGDEF domain
HL650_RS07335	COG2211	Major facilitator Superfamily
HL650_RS07340	COG3250	beta-galactosidase activity
HL650_RS07365	COG0745	RESPONSE REGULATOR receiver
HL650_RS07370	COG5002	protein histidine kinase activity
HL650_RS07375	COG1136	(ABC) transporter
HL650_RS07385	COG0745	RESPONSE REGULATOR receiver
HL650_RS07415	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HL650_RS07415	COG3453	Protein conserved in bacteria
HL650_RS07420	COG0596	Alpha beta hydrolase
HL650_RS07435	COG2176	DNA-directed DNA polymerase activity
HL650_RS07445	COG1702	phosphate starvation-inducible protein PhoH
HL650_RS07470	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HL650_RS07475	COG4224	UPF0291 protein
HL650_RS07480	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HL650_RS07485	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HL650_RS07495	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HL650_RS07500	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
HL650_RS07505	COG2081	HI0933 family
HL650_RS07510	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
HL650_RS07515	COG2003	Belongs to the UPF0758 family
HL650_RS07535	COG0768	penicillin binding
HL650_RS07540	COG2894	cell division
HL650_RS07545	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HL650_RS07555	COG1803	Methylglyoxal synthase
HL650_RS07560	COG1686	Belongs to the peptidase S11 family
HL650_RS07570	COG2155	Conserved Protein
HL650_RS07580	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HL650_RS07590	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HL650_RS07595	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HL650_RS07605	COG0564	pseudouridine synthase activity
HL650_RS07620	COG0037	tRNA processing
HL650_RS07625	COG0628	permease
HL650_RS07630	COG1490	D-aminoacyl-tRNA deacylase activity
HL650_RS07645	COG0745	RESPONSE REGULATOR receiver
HL650_RS07655	COG1136	(ABC) transporter
HL650_RS07655	COG0577	efflux transmembrane transporter activity
HL650_RS07665	COG0534	Mate efflux family protein
HL650_RS07675	COG1201	RNA secondary structure unwinding
HL650_RS07690	COG5002	protein histidine kinase activity
HL650_RS07695	COG0745	RESPONSE REGULATOR receiver
HL650_RS07705	COG2945	thiolester hydrolase activity
HL650_RS07705	COG0596	Alpha beta hydrolase
HL650_RS07725	COG0577	efflux transmembrane transporter activity
HL650_RS07725	COG1136	(ABC) transporter
HL650_RS07740	COG0697	spore germination
HL650_RS07745	COG2207	Transcriptional regulator
HL650_RS07745	COG1917	Cupin 2, conserved barrel domain protein
HL650_RS07760	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HL650_RS07775	COG0577	efflux transmembrane transporter activity
HL650_RS07780	COG1136	(ABC) transporter
HL650_RS07785	COG5002	protein histidine kinase activity
HL650_RS07790	COG0745	RESPONSE REGULATOR receiver
HL650_RS07800	COG2059	Chromate
HL650_RS07810	COG0583	DNA-binding transcription factor activity
HL650_RS07815	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HL650_RS07830	COG0488	(ABC) transporter
HL650_RS07835	COG1686	Belongs to the peptidase S11 family
HL650_RS07870	COG1131	(ABC) transporter
HL650_RS07890	COG0371	Dehydrogenase
HL650_RS07905	COG1609	Transcriptional regulator
HL650_RS07915	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HL650_RS07920	COG0799	negative regulation of ribosome biogenesis
HL650_RS07925	COG1713	HD superfamily hydrolase involved in NAD metabolism
HL650_RS07930	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HL650_RS07935	COG1534	Rna-binding protein
HL650_RS07940	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HL650_RS07945	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HL650_RS07965	COG1051	belongs to the nudix hydrolase family
HL650_RS07970	COG1530	ribonuclease E activity
HL650_RS08000	COG0646	methionine synthase
HL650_RS08000	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HL650_RS08010	COG4656	Part of a membrane complex involved in electron transport
HL650_RS08045	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HL650_RS08055	COG1131	(ABC) transporter
HL650_RS08060	COG0789	Transcriptional regulator
HL650_RS08105	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HL650_RS08110	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HL650_RS08120	COG0534	Mate efflux family protein
HL650_RS08145	COG2207	Transcriptional regulator
HL650_RS08170	COG0719	Fe-S assembly protein
HL650_RS08180	COG3192	ethanolamine utilization protein
HL650_RS08185	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
HL650_RS08195	COG4869	propanediol catabolic process
HL650_RS08210	COG1012	belongs to the aldehyde dehydrogenase family
HL650_RS08210	COG1454	alcohol dehydrogenase
HL650_RS08215	COG4816	utilization protein
HL650_RS08220	COG4302	ethanolamine ammonia-lyase activity
HL650_RS08225	COG4303	Ethanolamine ammonia lyase large subunit
HL650_RS08230	COG4819	ethanolamine utilization protein
HL650_RS08260	COG0577	efflux transmembrane transporter activity
HL650_RS08265	COG1136	(ABC) transporter
HL650_RS08270	COG2205	protein histidine kinase activity
HL650_RS08275	COG0745	RESPONSE REGULATOR receiver
HL650_RS08290	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HL650_RS08295	COG3331	DNA recombination
HL650_RS08300	COG0681	Belongs to the peptidase S26 family
HL650_RS08305	COG0564	pseudouridine synthase activity
HL650_RS08315	COG4221	oxidoreductase activity
HL650_RS08325	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HL650_RS08330	COG1187	pseudouridine synthase activity
HL650_RS08335	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
HL650_RS08335	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HL650_RS08340	COG2357	RelA SpoT domain protein
HL650_RS08345	COG0739	heme binding
HL650_RS08350	COG2195	Cleaves the N-terminal amino acid of tripeptides
HL650_RS08360	COG3314	Sporulation integral membrane protein YlbJ
HL650_RS08370	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HL650_RS08375	COG0742	ribosomal rna small subunit methyltransferase
HL650_RS08380	COG1803	Methylglyoxal synthase
HL650_RS08400	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HL650_RS08405	COG1461	Dihydroxyacetone kinase
HL650_RS08415	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HL650_RS08440	COG1051	belongs to the nudix hydrolase family
HL650_RS08445	COG0768	penicillin binding
HL650_RS08465	COG2255	four-way junction helicase activity
HL650_RS08470	COG0632	four-way junction helicase activity
HL650_RS08490	COG2878	Part of a membrane complex involved in electron transport
HL650_RS08490	COG1245	4Fe-4S binding domain
HL650_RS08495	COG4657	Part of a membrane complex involved in electron transport
HL650_RS08500	COG4660	Part of a membrane complex involved in electron transport
HL650_RS08510	COG4658	electron transport chain
HL650_RS08515	COG4656	Part of a membrane complex involved in electron transport
HL650_RS08530	COG0539	negative regulation of cytoplasmic translation
HL650_RS08530	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HL650_RS08535	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HL650_RS08545	COG2081	HI0933 family
HL650_RS08550	COG1737	Transcriptional regulator
HL650_RS08560	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HL650_RS08565	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HL650_RS08575	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HL650_RS08580	COG0159	tryptophan synthase activity
HL650_RS08590	COG0135	phosphoribosylanthranilate isomerase activity
HL650_RS08595	COG0134	indole-3-glycerol-phosphate synthase activity
HL650_RS08600	COG0512	Glutamine amidotransferase of anthranilate synthase
HL650_RS08600	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HL650_RS08625	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HL650_RS08645	COG1115	amino acid carrier protein
HL650_RS08650	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HL650_RS08665	COG2084	Dehydrogenase
HL650_RS08670	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HL650_RS08680	COG0071	Belongs to the small heat shock protein (HSP20) family
HL650_RS08695	COG1686	Belongs to the peptidase S11 family
HL650_RS08700	COG2270	Major facilitator Superfamily
HL650_RS08710	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HL650_RS08715	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HL650_RS08730	COG0714	Associated with various cellular activities
HL650_RS08735	COG1408	metallophosphoesterase
HL650_RS08740	COG0534	Mate efflux family protein
HL650_RS08745	COG1686	Belongs to the peptidase S11 family
HL650_RS08760	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HL650_RS08765	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HL650_RS08770	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HL650_RS08795	COG0328	RNA-DNA hybrid ribonuclease activity
HL650_RS08800	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HL650_RS08805	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HL650_RS08810	COG0113	porphobilinogen synthase activity
HL650_RS08825	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HL650_RS08830	COG0310	cobalt ion transport
HL650_RS08865	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HL650_RS08885	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HL650_RS08930	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
HL650_RS08935	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HL650_RS08950	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HL650_RS08955	COG3404	Formiminotransferase-cyclodeaminase
HL650_RS09000	COG1151	hydroxylamine reductase activity
HL650_RS09010	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HL650_RS09025	COG0419	ATPase involved in DNA repair
HL650_RS09030	COG0420	3'-5' exonuclease activity
HL650_RS09035	COG0656	L-ascorbic acid biosynthetic process
HL650_RS09040	COG1136	(ABC) transporter
HL650_RS09040	COG0577	efflux transmembrane transporter activity
HL650_RS09050	COG1136	(ABC) transporter
HL650_RS09050	COG0577	efflux transmembrane transporter activity
HL650_RS09055	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HL650_RS09065	COG1160	GTP binding
HL650_RS09075	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HL650_RS09090	COG0792	nuclease activity
HL650_RS09095	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HL650_RS09105	COG0681	Belongs to the peptidase S26 family
HL650_RS09110	COG0335	large ribosomal subunit rRNA binding
HL650_RS09125	COG1091	dTDP-4-dehydrorhamnose reductase activity
HL650_RS09130	COG4978	Transcriptional regulator
HL650_RS09130	COG0789	Transcriptional regulator
HL650_RS09145	COG1316	TRANSCRIPTIONal
HL650_RS09150	COG4509	Sortase family
HL650_RS09165	COG4464	protein tyrosine phosphatase activity
HL650_RS09230	COG1216	Glycosyl transferase, family 2
HL650_RS09240	COG0110	maltose O-acetyltransferase activity
HL650_RS09250	COG0535	radical SAM domain protein
HL650_RS09260	COG0438	transferase activity, transferring glycosyl groups
HL650_RS09270	COG0438	transferase activity, transferring glycosyl groups
HL650_RS09290	COG0336	Belongs to the RNA methyltransferase TrmD family
HL650_RS09295	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HL650_RS09300	COG1837	Belongs to the UPF0109 family
HL650_RS09310	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HL650_RS09345	COG1606	tRNA processing
HL650_RS09350	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
HL650_RS09355	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
HL650_RS09365	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HL650_RS09370	COG0552	protein localization to endoplasmic reticulum
HL650_RS09375	COG1196	nuclear chromosome segregation
HL650_RS09380	COG0571	ribonuclease III activity
HL650_RS09385	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HL650_RS09390	COG0416	fatty acid biosynthetic process
HL650_RS09400	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HL650_RS09425	COG1918	ferrous iron import across plasma membrane
HL650_RS09425	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HL650_RS09440	COG2848	UPF0210 protein
HL650_RS09450	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HL650_RS09455	COG0237	dephospho-CoA kinase activity
HL650_RS09460	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HL650_RS09460	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HL650_RS09465	COG1607	acyl-coa hydrolase
HL650_RS09495	COG1725	Transcriptional regulator
HL650_RS09500	COG0824	Thioesterase
HL650_RS09510	COG0527	aspartate kinase activity
HL650_RS09515	COG0436	Aminotransferase
HL650_RS09520	COG1522	sequence-specific DNA binding
HL650_RS09530	COG4149	molybdate abc transporter
HL650_RS09535	COG0725	ABC transporter, periplasmic molybdate-binding protein
HL650_RS09550	COG0697	spore germination
HL650_RS09570	COG0534	Mate efflux family protein
HL650_RS09585	COG0540	Belongs to the ATCase OTCase family
HL650_RS09595	COG1605	Chorismate mutase
HL650_RS09595	COG0077	Prephenate dehydratase
HL650_RS09625	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HL650_RS09630	COG0358	DNA primase activity
HL650_RS09635	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HL650_RS09640	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HL650_RS09650	COG4977	sequence-specific DNA binding
HL650_RS09680	COG1131	(ABC) transporter
HL650_RS09725	COG3279	Response regulator of the LytR AlgR family
HL650_RS09750	COG3158	transport of potassium into the cell
HL650_RS09755	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HL650_RS09755	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HL650_RS09770	COG0750	zinc metalloprotease
HL650_RS09780	COG4589	Belongs to the CDS family
HL650_RS09785	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HL650_RS09790	COG0233	cytoplasmic translational termination
HL650_RS09795	COG0528	UMP kinase activity
HL650_RS09805	COG0733	neurotransmitter:sodium symporter activity
HL650_RS09815	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HL650_RS09825	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
HL650_RS09835	COG0534	Mate efflux family protein
HL650_RS09840	COG3022	response to hydroperoxide
HL650_RS09845	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HL650_RS09860	COG2198	Histidine kinase
HL650_RS09860	COG2205	protein histidine kinase activity
HL650_RS09860	COG0784	Response regulator, receiver
HL650_RS09880	COG0534	Mate efflux family protein
HL650_RS09910	COG3340	Belongs to the peptidase S51 family
HL650_RS09915	COG2378	regulation of single-species biofilm formation
HL650_RS09930	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HL650_RS09940	COG1131	(ABC) transporter
HL650_RS09945	COG2188	Transcriptional regulator
HL650_RS09970	COG0746	molybdenum cofactor guanylyltransferase activity
HL650_RS09980	COG3383	formate dehydrogenase (NAD+) activity
HL650_RS10010	COG0398	Pfam SNARE associated Golgi protein
HL650_RS10015	COG0438	transferase activity, transferring glycosyl groups
HL650_RS10020	COG0438	transferase activity, transferring glycosyl groups
HL650_RS10215	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
HL650_RS10230	COG3723	Recombinational DNA repair protein, rece pathway
HL650_RS10240	COG5377	YqaJ viral recombinase family
HL650_RS10320	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HL650_RS10335	COG0165	Argininosuccinate lyase
HL650_RS10340	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HL650_RS10345	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HL650_RS10350	COG1116	anion transmembrane transporter activity
HL650_RS10355	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HL650_RS10370	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HL650_RS10380	COG1136	(ABC) transporter
HL650_RS10405	COG3279	Response regulator of the LytR AlgR family
HL650_RS10410	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HL650_RS10435	COG1177	transmembrane transport
HL650_RS10440	COG1176	ABC-type spermidine putrescine transport system, permease component I
HL650_RS10445	COG3842	ATPase activity
HL650_RS10455	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HL650_RS10460	COG1793	dna ligase
HL650_RS10485	COG0668	transmembrane transport
HL650_RS10490	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HL650_RS10495	COG0516	GMP reductase activity
HL650_RS10495	COG0517	IMP dehydrogenase activity
HL650_RS10525	COG0456	acetyltransferase
HL650_RS10530	COG1160	GTP binding
HL650_RS10540	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HL650_RS10555	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HL650_RS10560	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HL650_RS10565	COG0028	Belongs to the TPP enzyme family
HL650_RS10570	COG0129	dihydroxy-acid dehydratase activity
HL650_RS10605	COG1476	TRANSCRIPTIONal
HL650_RS10620	COG3708	Transcriptional regulator
HL650_RS10620	COG2207	Transcriptional regulator
HL650_RS10625	COG1760	l-serine dehydratase
HL650_RS10640	COG0343	queuine tRNA-ribosyltransferase activity
HL650_RS10660	COG5002	protein histidine kinase activity
HL650_RS10665	COG0745	RESPONSE REGULATOR receiver
HL650_RS10695	COG2205	protein histidine kinase activity
HL650_RS10725	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HL650_RS10730	COG0557	exoribonuclease II activity
HL650_RS10735	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HL650_RS10740	COG0148	phosphopyruvate hydratase activity
HL650_RS10775	COG4977	sequence-specific DNA binding
HL650_RS10780	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HL650_RS10785	COG1126	abc transporter atp-binding protein
HL650_RS10790	COG0765	amino acid transport
HL650_RS10795	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HL650_RS10810	COG0149	triose-phosphate isomerase activity
HL650_RS10825	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HL650_RS10830	COG0482	sulfurtransferase activity
HL650_RS10835	COG0822	iron-sulfur transferase activity
HL650_RS10845	COG1959	2 iron, 2 sulfur cluster binding
HL650_RS10850	COG2244	polysaccharide biosynthetic process
HL650_RS10870	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HL650_RS10875	COG4974	Belongs to the 'phage' integrase family
HL650_RS10885	COG1418	mRNA catabolic process
HL650_RS10895	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HL650_RS10915	COG1136	(ABC) transporter
HL650_RS10925	COG5002	protein histidine kinase activity
HL650_RS10930	COG0745	RESPONSE REGULATOR receiver
HL650_RS10935	COG0297	glycogen (starch) synthase activity
HL650_RS10940	COG0745	RESPONSE REGULATOR receiver
HL650_RS10945	COG0750	zinc metalloprotease
HL650_RS10950	COG0497	DNA recombination
HL650_RS10955	COG1438	arginine binding
HL650_RS10960	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HL650_RS10965	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HL650_RS10970	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HL650_RS10980	COG1722	exodeoxyribonuclease VII activity
HL650_RS10990	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HL650_RS10995	COG1302	Protein conserved in bacteria
HL650_RS11005	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HL650_RS11045	COG3854	ATPases associated with a variety of cellular activities
HL650_RS11060	COG1609	Transcriptional regulator
HL650_RS11060	COG2207	Transcriptional regulator
HL650_RS11065	COG4978	Transcriptional regulator
HL650_RS11065	COG0789	Transcriptional regulator
HL650_RS11070	COG0667	Aldo Keto reductase
HL650_RS11080	COG0210	DNA helicase
HL650_RS11085	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HL650_RS11100	COG0395	ABC-type sugar transport system, permease component
HL650_RS11110	COG1653	transport
HL650_RS11125	COG2080	2 iron, 2 sulfur cluster binding
HL650_RS11130	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HL650_RS11135	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HL650_RS11150	COG1501	Belongs to the glycosyl hydrolase 31 family
HL650_RS11155	COG0395	ABC-type sugar transport system, permease component
HL650_RS11160	COG1175	transmembrane transport
HL650_RS11165	COG2972	Histidine kinase
HL650_RS11170	COG4753	response regulator
HL650_RS11170	COG2207	Transcriptional regulator
HL650_RS11190	COG2070	2-Nitropropane dioxygenase
HL650_RS11200	COG0439	Biotin carboxylase
HL650_RS11205	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HL650_RS11210	COG0511	ligase activity, forming carbon-carbon bonds
HL650_RS11215	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HL650_RS11225	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HL650_RS11230	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HL650_RS11235	COG0772	Belongs to the SEDS family
HL650_RS11240	COG0584	glycerophosphoryl diester phosphodiesterase
HL650_RS11255	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
HL650_RS11285	COG1028	Short-chain dehydrogenase reductase Sdr
HL650_RS11290	COG1063	alcohol dehydrogenase
HL650_RS11295	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HL650_RS11305	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HL650_RS11315	COG2186	Transcriptional regulator
HL650_RS11335	COG2207	Transcriptional regulator
HL650_RS11335	COG1917	Cupin 2, conserved barrel domain protein
HL650_RS11345	COG0613	PHP domain protein
HL650_RS11355	COG1940	carbohydrate kinase activity
HL650_RS11365	COG3546	catalase activity
HL650_RS11370	COG2032	superoxide dismutase activity
HL650_RS11380	COG1979	alcohol dehydrogenase
HL650_RS11385	COG0656	L-ascorbic acid biosynthetic process
HL650_RS11395	COG1501	Belongs to the glycosyl hydrolase 31 family
HL650_RS11400	COG0513	Belongs to the DEAD box helicase family
HL650_RS11410	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HL650_RS11420	COG2378	regulation of single-species biofilm formation
HL650_RS11430	COG1285	pathogenesis
HL650_RS11440	COG0688	phosphatidylethanolamine metabolic process
HL650_RS11465	COG4977	sequence-specific DNA binding
HL650_RS11465	COG1917	Cupin 2, conserved barrel domain protein
HL650_RS11470	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HL650_RS11470	COG0574	Belongs to the PEP-utilizing enzyme family
HL650_RS11475	COG4989	oxidoreductase activity
HL650_RS11485	COG3681	Belongs to the UPF0597 family
HL650_RS11490	COG4753	response regulator
HL650_RS11490	COG2207	Transcriptional regulator
HL650_RS11495	COG0395	ABC-type sugar transport system, permease component
HL650_RS11500	COG1175	transmembrane transport
HL650_RS11505	COG1653	transport
HL650_RS11515	COG2972	Histidine kinase
HL650_RS11535	COG0395	ABC-type sugar transport system, permease component
HL650_RS11540	COG1175	transmembrane transport
HL650_RS11545	COG1653	transport
HL650_RS11550	COG1621	beta-fructofuranosidase activity
HL650_RS11555	COG1609	Transcriptional regulator
HL650_RS11560	COG0423	glycine-tRNA ligase activity
HL650_RS11565	COG1381	Involved in DNA repair and RecF pathway recombination
HL650_RS11570	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HL650_RS11590	COG0584	glycerophosphoryl diester phosphodiesterase
HL650_RS11605	COG1959	2 iron, 2 sulfur cluster binding
HL650_RS11610	COG0488	(ABC) transporter
HL650_RS11615	COG0019	diaminopimelate decarboxylase activity
HL650_RS11620	COG0583	DNA-binding transcription factor activity
HL650_RS11635	COG1846	Transcriptional regulator
HL650_RS11645	COG1940	carbohydrate kinase activity
HL650_RS11650	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HL650_RS11655	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HL650_RS11770	COG0484	heat shock protein binding
HL650_RS11790	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
HL650_RS11795	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HL650_RS11800	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HL650_RS11805	COG1187	pseudouridine synthase activity
HL650_RS11850	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
HL650_RS11855	COG0372	Belongs to the citrate synthase family
HL650_RS11860	COG0640	Transcriptional regulator
HL650_RS11870	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HL650_RS11875	COG1132	(ABC) transporter
HL650_RS11890	COG0534	Mate efflux family protein
HL650_RS11895	COG0436	Aminotransferase
HL650_RS11900	COG4608	Belongs to the ABC transporter superfamily
HL650_RS11905	COG0444	Belongs to the ABC transporter superfamily
HL650_RS11925	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HL650_RS11935	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HL650_RS11940	COG1363	Peptidase, m42
HL650_RS11960	COG1191	sigma factor activity
HL650_RS11970	COG1968	undecaprenyl-diphosphatase activity
HL650_RS11975	COG3534	alpha-L-arabinofuranosidase
HL650_RS11990	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HL650_RS12000	COG0800	Aldolase
HL650_RS12005	COG1414	Transcriptional regulator
HL650_RS12010	COG1191	sigma factor activity
HL650_RS12020	COG0710	3-dehydroquinate dehydratase activity
HL650_RS12025	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HL650_RS12040	COG0521	Mo-molybdopterin cofactor biosynthetic process
HL650_RS12060	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HL650_RS12065	COG0772	Belongs to the SEDS family
HL650_RS12070	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HL650_RS12080	COG0768	penicillin binding
HL650_RS12085	COG0768	penicillin binding
HL650_RS12100	COG2001	Belongs to the MraZ family
HL650_RS12115	COG0012	GTP binding
HL650_RS12120	COG1564	THIamine pyrophosphokinase
HL650_RS12130	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HL650_RS12140	COG2815	serine threonine protein kinase
HL650_RS12140	COG0515	serine threonine protein kinase
HL650_RS12145	COG0631	protein serine/threonine phosphatase activity
HL650_RS12150	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HL650_RS12175	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HL650_RS12180	COG0549	Belongs to the carbamate kinase family
HL650_RS12200	COG0446	pyridine nucleotide-disulphide oxidoreductase
HL650_RS12200	COG1902	pentaerythritol trinitrate reductase activity
HL650_RS12205	COG1968	undecaprenyl-diphosphatase activity
HL650_RS12285	COG4115	mRNA cleavage
HL650_RS12335	COG0740	serine-type endopeptidase activity
HL650_RS12345	COG1802	Transcriptional regulator
HL650_RS12345	COG4626	Terminase
HL650_RS12380	COG0175	sulfate reduction
HL650_RS12435	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HL650_RS12435	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HL650_RS12515	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HL650_RS12520	COG1134	teichoic acid transport
HL650_RS12530	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HL650_RS12535	COG0463	Glycosyl transferase, family 2
HL650_RS12540	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HL650_RS12545	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HL650_RS12555	COG1216	Glycosyl transferase, family 2
HL650_RS12560	COG0438	transferase activity, transferring glycosyl groups
HL650_RS12560	COG1216	Glycosyl transferase, family 2
HL650_RS12575	COG0438	transferase activity, transferring glycosyl groups
HL650_RS12575	COG1216	Glycosyl transferase, family 2
HL650_RS12600	COG1682	transport, permease protein
HL650_RS12605	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
HL650_RS12610	COG1686	Belongs to the peptidase S11 family
HL650_RS12640	COG3475	LICD family
HL650_RS12645	COG0562	UDP-galactopyranose mutase
HL650_RS12650	COG1442	glycosyl transferase family 8
HL650_RS12665	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HL650_RS12675	COG0463	Glycosyl transferase, family 2
HL650_RS12685	COG0151	Belongs to the GarS family
HL650_RS12690	COG1376	ErfK ybiS ycfS ynhG family protein
HL650_RS12715	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HL650_RS12730	COG1040	competence protein
HL650_RS12735	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HL650_RS12755	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HL650_RS12760	COG0481	GTPase activity
HL650_RS12770	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HL650_RS12775	COG0268	Binds directly to 16S ribosomal RNA
HL650_RS12795	COG5002	protein histidine kinase activity
HL650_RS12800	COG0745	RESPONSE REGULATOR receiver
HL650_RS12805	COG0322	excinuclease ABC activity
HL650_RS12815	COG1459	type II secretion system
HL650_RS12855	COG0305	Participates in initiation and elongation during chromosome replication
HL650_RS12860	COG0359	binds to the 23S rRNA
HL650_RS12865	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
HL650_RS12880	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HL650_RS12885	COG0629	single-stranded DNA binding
HL650_RS12890	COG0360	Binds together with S18 to 16S ribosomal RNA
HL650_RS12905	COG4509	Sortase family
HL650_RS12920	COG1472	Belongs to the glycosyl hydrolase 3 family
HL650_RS12930	COG0366	Alpha amylase catalytic
HL650_RS12940	COG0110	maltose O-acetyltransferase activity
HL650_RS12945	COG0673	inositol 2-dehydrogenase activity
HL650_RS12970	COG0673	inositol 2-dehydrogenase activity
HL650_RS12975	COG2211	Major facilitator Superfamily
HL650_RS12980	COG3664	PFAM glycoside hydrolase family 39
HL650_RS12985	COG0322	excinuclease ABC activity
HL650_RS12990	COG0275	rRNA processing
HL650_RS13020	COG0395	ABC-type sugar transport system, permease component
HL650_RS13025	COG1175	transmembrane transport
HL650_RS13030	COG1653	transport
HL650_RS13035	COG2986	histidine ammonia-lyase
HL650_RS13055	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HL650_RS13065	COG1086	Polysaccharide biosynthesis protein
HL650_RS13090	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HL650_RS13105	COG0110	maltose O-acetyltransferase activity
HL650_RS13115	COG0151	Belongs to the GarS family
HL650_RS13120	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HL650_RS13125	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HL650_RS13130	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HL650_RS13165	COG0745	RESPONSE REGULATOR receiver
HL650_RS13165	COG4566	intracellular signal transduction
HL650_RS13170	COG1268	BioY protein
HL650_RS13180	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HL650_RS13230	COG0110	maltose O-acetyltransferase activity
HL650_RS13245	COG2188	Transcriptional regulator
HL650_RS13255	COG0784	Response regulator, receiver
HL650_RS13255	COG2205	protein histidine kinase activity
HL650_RS13255	COG5002	protein histidine kinase activity
HL650_RS13260	COG1671	Belongs to the UPF0178 family
HL650_RS13265	COG0642	Histidine kinase
HL650_RS13270	COG0745	RESPONSE REGULATOR receiver
HL650_RS13280	COG1136	(ABC) transporter
HL650_RS13285	COG3708	Transcriptional regulator
HL650_RS13285	COG2207	Transcriptional regulator
HL650_RS13290	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HL650_RS13295	COG1408	metallophosphoesterase
HL650_RS13300	COG4536	flavin adenine dinucleotide binding
HL650_RS13320	COG4974	Belongs to the 'phage' integrase family
HL650_RS13325	COG1115	amino acid carrier protein
HL650_RS13330	COG0686	Belongs to the AlaDH PNT family
HL650_RS13350	COG0582	viral genome integration into host DNA
HL650_RS13355	COG5001	Diguanylate cyclase
HL650_RS13355	COG4251	negative regulation of phosphorylation
HL650_RS13355	COG2203	Gaf domain
HL650_RS13355	COG3706	GGDEF domain
HL650_RS13360	COG1132	(ABC) transporter
HL650_RS13390	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HL650_RS13395	COG3958	Transketolase
HL650_RS13400	COG3959	Transketolase, thiamine diphosphate binding domain
HL650_RS13420	COG0395	ABC-type sugar transport system, permease component
HL650_RS13425	COG1175	transmembrane transport
HL650_RS13435	COG0357	Ribosomal RNA small subunit methyltransferase G
HL650_RS13450	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HL650_RS13470	COG1346	cytolysis
HL650_RS13475	COG1380	Effector of murein hydrolase LrgA
HL650_RS13485	COG1874	Beta-galactosidase
HL650_RS13490	COG3250	beta-galactosidase activity
HL650_RS13510	COG2207	Transcriptional regulator
HL650_RS13510	COG3708	Transcriptional regulator
HL650_RS13515	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HL650_RS13530	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HL650_RS13535	COG0367	asparagine synthase
HL650_RS13540	COG1720	tRNA m6t6A37 methyltransferase activity
HL650_RS13575	COG1131	(ABC) transporter
HL650_RS13590	COG1131	(ABC) transporter
HL650_RS13600	COG1595	DNA-templated transcription, initiation
HL650_RS13610	COG1082	Xylose isomerase domain protein TIM barrel
HL650_RS13615	COG1082	Xylose isomerase domain protein TIM barrel
HL650_RS13630	COG0673	inositol 2-dehydrogenase activity
HL650_RS13635	COG1609	Transcriptional regulator
HL650_RS13650	COG1136	(ABC) transporter
HL650_RS13670	COG2972	Histidine kinase
HL650_RS13675	COG2207	Transcriptional regulator
HL650_RS13675	COG4753	response regulator
HL650_RS13680	COG4211	Belongs to the binding-protein-dependent transport system permease family
HL650_RS13685	COG1129	ABC transporter
HL650_RS13690	COG1879	ABC-type sugar transport system periplasmic component
HL650_RS13710	COG0395	ABC-type sugar transport system, permease component
HL650_RS13715	COG1175	transmembrane transport
HL650_RS13725	COG1609	Transcriptional regulator
HL650_RS13755	COG2738	Putative neutral zinc metallopeptidase
HL650_RS13780	COG5598	trimethylamine methyltransferase
HL650_RS13785	COG5012	cobalamin binding
HL650_RS13790	COG2207	Transcriptional regulator
HL650_RS13805	COG1131	(ABC) transporter
HL650_RS13830	COG1131	(ABC) transporter
HL650_RS13870	COG1131	(ABC) transporter
HL650_RS13885	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HL650_RS13920	COG5002	protein histidine kinase activity
HL650_RS13945	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HL650_RS13945	COG2508	Transcriptional regulator
HL650_RS13990	COG2205	protein histidine kinase activity
HL650_RS14005	COG0745	RESPONSE REGULATOR receiver
HL650_RS14020	COG0242	peptide deformylase activity
HL650_RS14085	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HL650_RS14095	COG1234	tRNA 3'-trailer cleavage
HL650_RS14105	COG0456	acetyltransferase
HL650_RS14110	COG1214	PFAM Peptidase M22, glycoprotease
HL650_RS14115	COG0802	atpase or kinase
HL650_RS14120	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HL650_RS14125	COG1739	Uncharacterized protein family UPF0029
HL650_RS14135	COG1940	carbohydrate kinase activity
HL650_RS14140	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HL650_RS14145	COG0322	excinuclease ABC activity
HL650_RS14155	COG4868	Belongs to the UPF0371 family
HL650_RS14160	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HL650_RS14210	COG3646	Phage regulatory protein
HL650_RS14540	COG0363	glucosamine-6-phosphate deaminase activity
HL650_RS14545	COG1668	transmembrane transport
HL650_RS14550	COG4152	abc transporter atp-binding protein
HL650_RS14560	COG1476	TRANSCRIPTIONal
HL650_RS14570	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HL650_RS14580	COG2217	Heavy metal translocating P-type atpase
HL650_RS14590	COG0569	domain protein
HL650_RS14600	COG3546	catalase activity
HL650_RS14625	COG5002	protein histidine kinase activity
HL650_RS14635	COG1283	sodium-dependent phosphate transmembrane transporter activity
HL650_RS14640	COG0456	acetyltransferase
HL650_RS14665	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HL650_RS14670	COG1827	regulation of RNA biosynthetic process
HL650_RS14675	COG0157	Belongs to the NadC ModD family
HL650_RS14685	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HL650_RS14695	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HL650_RS14700	COG0534	Mate efflux family protein
HL650_RS14715	COG2205	protein histidine kinase activity
HL650_RS14785	COG2205	protein histidine kinase activity
HL650_RS14790	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HL650_RS14795	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HL650_RS14800	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HL650_RS14835	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HL650_RS14840	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HL650_RS14845	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HL650_RS14870	COG1940	carbohydrate kinase activity
HL650_RS14875	COG0572	uridine kinase
HL650_RS14880	COG0431	NADPH-dependent FMN reductase
HL650_RS14885	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HL650_RS14890	COG2252	PERMEase
HL650_RS14915	COG1687	branched-chain amino acid
HL650_RS14920	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HL650_RS14930	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HL650_RS14940	COG3620	sequence-specific DNA binding
HL650_RS14945	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HL650_RS14950	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HL650_RS14955	COG2706	6-phosphogluconolactonase activity
HL650_RS14960	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HL650_RS15000	COG0395	ABC-type sugar transport system, permease component
HL650_RS15005	COG1175	transmembrane transport
HL650_RS15020	COG2207	Transcriptional regulator
HL650_RS15020	COG4753	response regulator
HL650_RS15025	COG3275	phosphorelay sensor kinase activity
HL650_RS15050	COG0395	ABC-type sugar transport system, permease component
HL650_RS15055	COG4209	transmembrane transport
HL650_RS15065	COG3250	beta-galactosidase activity
HL650_RS15095	COG1349	DNA-binding transcription factor activity
HL650_RS15105	COG4608	Belongs to the ABC transporter superfamily
HL650_RS15110	COG0444	Belongs to the ABC transporter superfamily
HL650_RS15115	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HL650_RS15120	COG0601	transmembrane transport
HL650_RS15125	COG4166	transmembrane transport
HL650_RS15205	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HL650_RS15210	COG3481	metal-dependent phosphohydrolase, HD sub domain
HL650_RS15215	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HL650_RS15220	COG1193	negative regulation of DNA recombination
HL650_RS15225	COG0745	RESPONSE REGULATOR receiver
HL650_RS15230	COG5002	protein histidine kinase activity
HL650_RS15240	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HL650_RS15250	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HL650_RS15275	COG0475	glutathione-regulated potassium exporter activity
HL650_RS15280	COG1328	CTP reductase activity
HL650_RS15285	COG0534	Mate efflux family protein
HL650_RS15290	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HL650_RS15300	COG0446	pyridine nucleotide-disulphide oxidoreductase
HL650_RS15305	COG0583	DNA-binding transcription factor activity
HL650_RS15310	COG1773	rubredoxin
HL650_RS15325	COG2986	histidine ammonia-lyase
HL650_RS15335	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HL650_RS15355	COG1175	transmembrane transport
HL650_RS15360	COG1653	transport
HL650_RS15365	COG0662	Cupin 2, conserved barrel domain protein
HL650_RS15365	COG2207	Transcriptional regulator
HL650_RS15375	COG2223	nitrite transmembrane transporter activity
HL650_RS15380	COG1349	DNA-binding transcription factor activity
HL650_RS15385	COG1082	Xylose isomerase domain protein TIM barrel
HL650_RS15390	COG0673	inositol 2-dehydrogenase activity
HL650_RS15415	COG2207	Transcriptional regulator
HL650_RS15415	COG4753	response regulator
HL650_RS15420	COG2972	Histidine kinase
HL650_RS15425	COG0673	inositol 2-dehydrogenase activity
HL650_RS15435	COG2211	Major facilitator Superfamily
HL650_RS15455	COG3962	Belongs to the TPP enzyme family
HL650_RS15460	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HL650_RS15495	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HL650_RS15545	COG2801	Transposase and inactivated derivatives
HL650_RS15765	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
HL650_RS15780	COG3723	Recombinational DNA repair protein, rece pathway
HL650_RS15790	COG5377	YqaJ viral recombinase family
HL650_RS15835	COG1396	sequence-specific DNA binding
HL650_RS15885	COG0622	Phosphoesterase
HL650_RS15890	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HL650_RS15895	COG0116	Belongs to the methyltransferase superfamily
HL650_RS15900	COG0622	Phosphoesterase
HL650_RS15920	COG1501	Belongs to the glycosyl hydrolase 31 family
HL650_RS15945	COG1609	Transcriptional regulator
HL650_RS15950	COG3250	beta-galactosidase activity
HL650_RS15960	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HL650_RS15965	COG1940	carbohydrate kinase activity
HL650_RS15980	COG1175	transmembrane transport
HL650_RS15985	COG1653	transport
HL650_RS15990	COG1940	carbohydrate kinase activity
HL650_RS16005	COG0436	Aminotransferase
HL650_RS16010	COG1132	(ABC) transporter
HL650_RS16020	COG2116	formate transmembrane transporter activity
HL650_RS16025	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HL650_RS16035	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HL650_RS16040	COG1696	Membrane protein involved in D-alanine export
HL650_RS16050	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
HL650_RS16060	COG0745	RESPONSE REGULATOR receiver
HL650_RS16065	COG2205	protein histidine kinase activity
HL650_RS16070	COG0569	domain protein
HL650_RS16075	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HL650_RS16095	COG0582	viral genome integration into host DNA
HL650_RS16105	COG1309	transcriptional regulator
HL650_RS16120	COG2161	toxin-antitoxin pair type II binding
HL650_RS16135	COG0395	ABC-type sugar transport system, permease component
HL650_RS16140	COG1175	transmembrane transport
HL650_RS16150	COG2972	Histidine kinase
HL650_RS16155	COG4753	response regulator
HL650_RS16155	COG2207	Transcriptional regulator
HL650_RS16180	COG1028	Short-chain dehydrogenase reductase Sdr
HL650_RS16185	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
HL650_RS16245	COG3250	beta-galactosidase activity
HL650_RS16250	COG0534	Mate efflux family protein
HL650_RS16255	COG2207	Transcriptional regulator
HL650_RS16270	COG0395	ABC-type sugar transport system, permease component
HL650_RS16275	COG4209	transmembrane transport
HL650_RS16280	COG1609	Transcriptional regulator
HL650_RS16300	COG0006	proline dipeptidase activity
HL650_RS16305	COG2183	response to ionizing radiation
HL650_RS16310	COG1070	Carbohydrate kinase
HL650_RS16335	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
HL650_RS16340	COG0460	homoserine dehydrogenase
HL650_RS16345	COG4492	Belongs to the UPF0735 family
HL650_RS16360	COG0653	protein targeting
HL650_RS16365	COG1924	4 iron, 4 sulfur cluster binding
HL650_RS16375	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HL650_RS16385	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HL650_RS16390	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HL650_RS16395	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HL650_RS16410	COG1012	belongs to the aldehyde dehydrogenase family
HL650_RS16410	COG1454	alcohol dehydrogenase
HL650_RS16420	COG0726	polysaccharide deacetylase
HL650_RS16425	COG1115	amino acid carrier protein
HL650_RS16435	COG1971	Probably functions as a manganese efflux pump
HL650_RS16455	COG5002	protein histidine kinase activity
HL650_RS16475	COG1472	Belongs to the glycosyl hydrolase 3 family
HL650_RS16480	COG4753	response regulator
HL650_RS16480	COG2207	Transcriptional regulator
HL650_RS16485	COG2972	Histidine kinase
HL650_RS16555	COG2267	carboxylic ester hydrolase activity
HL650_RS16560	COG2814	Major facilitator Superfamily
HL650_RS16570	COG1131	(ABC) transporter
HL650_RS16575	COG1309	transcriptional regulator
HL650_RS16585	COG0737	Belongs to the 5'-nucleotidase family
HL650_RS16605	COG0395	ABC-type sugar transport system, permease component
HL650_RS16620	COG2207	Transcriptional regulator
HL650_RS16620	COG4753	response regulator
HL650_RS16625	COG2972	Histidine kinase
HL650_RS16655	COG0395	ABC-type sugar transport system, permease component
HL650_RS16660	COG4209	transmembrane transport
HL650_RS16665	COG1609	Transcriptional regulator
HL650_RS16710	COG3550	peptidyl-serine autophosphorylation
HL650_RS16785	COG4555	ABC transporter
HL650_RS16790	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HL650_RS16795	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HL650_RS16795	COG1605	Chorismate mutase
HL650_RS16800	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HL650_RS16810	COG0318	PFAM AMP-dependent synthetase and ligase
HL650_RS16815	COG1216	Glycosyl transferase, family 2
HL650_RS16815	COG0463	Glycosyl transferase, family 2
HL650_RS16845	COG0535	radical SAM domain protein
HL650_RS16850	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HL650_RS16855	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HL650_RS16875	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HL650_RS16880	COG0546	phosphoglycolate phosphatase activity
HL650_RS16890	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HL650_RS16895	COG1940	carbohydrate kinase activity
HL650_RS16905	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HL650_RS16905	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HL650_RS16930	COG3344	reverse transcriptase
HL650_RS16950	COG0519	Catalyzes the synthesis of GMP from XMP
HL650_RS16960	COG1609	Transcriptional regulator
HL650_RS16970	COG0658	competence protein
HL650_RS16970	COG2333	competence protein COMEC
HL650_RS16975	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HL650_RS16980	COG0534	Mate efflux family protein
HL650_RS16985	COG2706	6-phosphogluconolactonase activity
HL650_RS16995	COG1472	Belongs to the glycosyl hydrolase 3 family
HL650_RS17000	COG4753	response regulator
HL650_RS17000	COG2207	Transcriptional regulator
HL650_RS17015	COG2223	nitrite transmembrane transporter activity
HL650_RS17020	COG1394	ATPase activity, coupled to movement of substances
HL650_RS17025	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
HL650_RS17030	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
HL650_RS17035	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
HL650_RS17050	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HL650_RS17055	COG1269	ATP hydrolysis coupled proton transport
HL650_RS17065	COG1879	ABC-type sugar transport system periplasmic component
HL650_RS17075	COG0564	pseudouridine synthase activity
HL650_RS17080	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HL650_RS17085	COG3835	regulator
HL650_RS17090	COG3842	ATPase activity
HL650_RS17095	COG5002	protein histidine kinase activity
HL650_RS17115	COG0166	Belongs to the GPI family
HL650_RS17125	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HL650_RS17130	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HL650_RS17145	COG1233	COG1233 Phytoene dehydrogenase and related
HL650_RS17155	COG2226	methyltransferase
HL650_RS17170	COG1104	cysteine desulfurase activity
HL650_RS17180	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HL650_RS17195	COG0129	dihydroxy-acid dehydratase activity
HL650_RS17285	COG3279	Response regulator of the LytR AlgR family
HL650_RS17315	COG1131	(ABC) transporter
HL650_RS17350	COG1131	(ABC) transporter
HL650_RS17355	COG4585	Histidine kinase
HL650_RS17360	COG2197	response regulator
HL650_RS17375	COG1695	Transcriptional regulator
HL650_RS17410	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HL650_RS17420	COG0537	adenosine 5'-monophosphoramidase activity
HL650_RS17425	COG5002	protein histidine kinase activity
HL650_RS17430	COG0705	Rhomboid family
HL650_RS17430	COG0457	Tetratricopeptide repeat
HL650_RS17435	COG1716	ATPase activity
HL650_RS17495	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HL650_RS17520	COG0281	malic enzyme
HL650_RS17550	COG3275	phosphorelay sensor kinase activity
HL650_RS17555	COG2201	protein-glutamate methylesterase activity
HL650_RS17560	COG0733	neurotransmitter:sodium symporter activity
HL650_RS17605	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HL650_RS17620	COG1269	ATP hydrolysis coupled proton transport
HL650_RS17640	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
HL650_RS17650	COG1394	ATPase activity, coupled to movement of substances
HL650_RS17655	COG5002	protein histidine kinase activity
HL650_RS17665	COG0573	inorganic phosphate transmembrane transporter activity
HL650_RS17670	COG0581	inorganic phosphate transmembrane transporter activity
HL650_RS17675	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HL650_RS17680	COG0704	Plays a role in the regulation of phosphate uptake
HL650_RS17690	COG5002	protein histidine kinase activity
HL650_RS17695	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HL650_RS17700	COG0492	ferredoxin-NADP+ reductase activity
HL650_RS17730	COG1349	DNA-binding transcription factor activity
HL650_RS17735	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HL650_RS17745	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HL650_RS17745	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HL650_RS17745	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HL650_RS17750	COG1105	Belongs to the carbohydrate kinase PfkB family
HL650_RS17770	COG4869	propanediol catabolic process
HL650_RS17780	COG1063	alcohol dehydrogenase
HL650_RS17795	COG1486	melibiose metabolic process
HL650_RS17800	COG0395	ABC-type sugar transport system, permease component
HL650_RS17805	COG1175	transmembrane transport
HL650_RS17830	COG0140	phosphoribosyl-ATP diphosphatase activity
HL650_RS17835	COG0140	phosphoribosyl-ATP diphosphatase activity
HL650_RS17835	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HL650_RS17840	COG0107	imidazoleglycerol-phosphate synthase activity
HL650_RS17850	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HL650_RS17855	COG0131	Imidazoleglycerol-phosphate dehydratase
HL650_RS17860	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HL650_RS17865	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HL650_RS17870	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HL650_RS17875	COG2205	protein histidine kinase activity
HL650_RS17875	COG0784	Response regulator, receiver
HL650_RS17875	COG2198	Histidine kinase
HL650_RS17880	COG0700	Nucleoside recognition
HL650_RS17900	COG2059	Chromate
HL650_RS17920	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HL650_RS17935	COG0523	cobalamin synthesis protein
HL650_RS17945	COG1136	(ABC) transporter
HL650_RS17950	COG2205	protein histidine kinase activity
HL650_RS17955	COG0745	RESPONSE REGULATOR receiver
HL650_RS17970	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HL650_RS17985	COG4977	sequence-specific DNA binding
HL650_RS17995	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HL650_RS18000	COG2104	thiamine diphosphate biosynthetic process
HL650_RS18005	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HL650_RS18010	COG2022	thiamine diphosphate biosynthetic process
HL650_RS18020	COG0352	thiamine-phosphate diphosphorylase activity
HL650_RS18145	COG0631	protein serine/threonine phosphatase activity
HL650_RS18150	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HL650_RS18165	COG1309	transcriptional regulator
HL650_RS18170	COG0084	hydrolase, TatD family'
HL650_RS18175	COG0628	permease
HL650_RS18180	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HL650_RS18200	COG0363	glucosamine-6-phosphate deaminase activity
HL650_RS18205	COG0395	ABC-type sugar transport system, permease component
HL650_RS18210	COG1175	transmembrane transport
HL650_RS18220	COG2971	BadF BadG BcrA BcrD
HL650_RS18225	COG1486	melibiose metabolic process
HL650_RS18245	COG2211	Major facilitator Superfamily
HL650_RS18250	COG1082	Xylose isomerase domain protein TIM barrel
HL650_RS18255	COG1082	Xylose isomerase domain protein TIM barrel
HL650_RS18260	COG0673	inositol 2-dehydrogenase activity
HL650_RS18265	COG1917	Cupin 2, conserved barrel domain protein
HL650_RS18265	COG2207	Transcriptional regulator
HL650_RS18285	COG2972	Histidine kinase
HL650_RS18290	COG2207	Transcriptional regulator
HL650_RS18290	COG4753	response regulator
HL650_RS18295	COG0395	ABC-type sugar transport system, permease component
HL650_RS18320	COG0534	Mate efflux family protein
HL650_RS18325	COG0069	glutamate synthase activity
HL650_RS18330	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HL650_RS18350	COG0149	triose-phosphate isomerase activity
HL650_RS18360	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HL650_RS18365	COG1063	alcohol dehydrogenase
HL650_RS18370	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HL650_RS18375	COG3959	Transketolase, thiamine diphosphate binding domain
HL650_RS18380	COG1028	Short-chain dehydrogenase reductase Sdr
HL650_RS18395	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HL650_RS18400	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HL650_RS18410	COG1609	Transcriptional regulator
HL650_RS18415	COG1609	Transcriptional regulator
HL650_RS18420	COG2715	membrane protein required for spore maturation
HL650_RS18425	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HL650_RS18430	COG2843	Capsule synthesis protein
HL650_RS18435	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HL650_RS18440	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HL650_RS18445	COG1774	PSP1 C-terminal conserved region
HL650_RS18455	COG0194	GDP metabolic process
HL650_RS18460	COG1982	Orn Lys Arg decarboxylase major
HL650_RS18460	COG1982	Orn Lys Arg decarboxylase major
HL650_RS18465	COG0442	prolyl-tRNA aminoacylation
HL650_RS18500	COG0745	RESPONSE REGULATOR receiver
HL650_RS18505	COG5002	protein histidine kinase activity
HL650_RS18520	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HL650_RS18525	COG1028	Short-chain dehydrogenase reductase Sdr
HL650_RS18530	COG0129	dihydroxy-acid dehydratase activity
HL650_RS18535	COG2186	Transcriptional regulator
HL650_RS18540	COG2610	gluconate transmembrane transporter activity
HL650_RS18550	COG1063	alcohol dehydrogenase
HL650_RS18560	COG0395	ABC-type sugar transport system, permease component
HL650_RS18565	COG1175	transmembrane transport
HL650_RS18575	COG3708	Transcriptional regulator
HL650_RS18575	COG2207	Transcriptional regulator
HL650_RS18600	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HL650_RS18605	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HL650_RS18610	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HL650_RS18615	COG1501	Belongs to the glycosyl hydrolase 31 family
HL650_RS18645	COG2357	RelA SpoT domain protein
HL650_RS18650	COG4086	secreted protein
HL650_RS18660	COG2211	Major facilitator Superfamily
HL650_RS18665	COG3250	beta-galactosidase activity
HL650_RS18675	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HL650_RS18675	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HL650_RS18695	COG3842	ATPase activity
HL650_RS18705	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HL650_RS18715	COG0058	SHG alpha-glucan phosphorylase activity
HL650_RS18720	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HL650_RS18735	COG1131	(ABC) transporter
HL650_RS18745	COG1686	Belongs to the peptidase S11 family
HL650_RS18760	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HL650_RS18765	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HL650_RS18780	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HL650_RS18785	COG0017	Asparaginyl-tRNA synthetase
HL650_RS18790	COG0436	Aminotransferase
HL650_RS18805	COG0473	3-isopropylmalate dehydrogenase activity
HL650_RS18835	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HL650_RS18850	COG1459	type II secretion system
HL650_RS18855	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HL650_RS18875	COG0514	ATP-dependent DNA helicase (RecQ)
HL650_RS18885	COG0493	'glutamate synthase
HL650_RS18890	COG0067	glutamate synthase
HL650_RS18890	COG0070	glutamate synthase
HL650_RS18890	COG0069	glutamate synthase activity
HL650_RS18895	COG0504	CTP synthase activity
HL650_RS18910	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HL650_RS18915	COG0004	ammonium transporteR
HL650_RS18960	COG2267	carboxylic ester hydrolase activity
HL650_RS18965	COG5566	PFAM Mor transcription activator
HL650_RS18975	COG0791	NLP P60 protein
HL650_RS18975	COG0741	lytic transglycosylase activity
HL650_RS19010	COG2946	Replication initiation factor
HL650_RS19015	COG1674	ftsk spoiiie
HL650_RS19065	COG0395	ABC-type sugar transport system, permease component
HL650_RS19080	COG2207	Transcriptional regulator
HL650_RS19080	COG4753	response regulator
HL650_RS19085	COG2972	Histidine kinase
HL650_RS19090	COG5001	Diguanylate cyclase
HL650_RS19090	COG5002	protein histidine kinase activity
HL650_RS19100	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HL650_RS19110	COG1475	DNA binding
HL650_RS19115	COG1192	Involved in chromosome partitioning
HL650_RS19140	COG1131	(ABC) transporter
HL650_RS19165	COG0357	Ribosomal RNA small subunit methyltransferase G
HL650_RS19170	COG0445	tRNA wobble uridine modification
HL650_RS19175	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HL650_RS19180	COG1847	R3H domain protein
HL650_RS19185	COG0706	membrane insertase activity
HL650_RS19195	COG0594	ribonuclease P activity
HL650_RS19200	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HL650_RS19210	COG0592	DNA-directed DNA polymerase activity
HL650_RS19220	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HL650_RS19225	COG0187	DNA topoisomerase II activity
HL650_RS19230	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HL650_RS19360	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HL650_RS19360	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HL650_RS19570	COG0534	Mate efflux family protein
HL650_RS19575	COG2873	o-acetylhomoserine
HL650_RS19580	COG0275	rRNA processing
HL650_RS19610	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HL650_RS19615	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
HL650_RS19620	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HL650_RS19625	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HL650_RS19630	COG2731	YhcH YjgK YiaL family protein
HL650_RS19640	COG1737	Transcriptional regulator
HL650_RS19645	COG0735	belongs to the Fur family
HL650_RS19650	COG1773	rubredoxin
HL650_RS19650	COG1592	Rubrerythrin
HL650_RS19655	COG1592	Rubrerythrin
HL650_RS19665	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HL650_RS19670	COG1846	Transcriptional regulator
HL650_RS19670	COG1940	carbohydrate kinase activity
HL650_RS19695	COG0784	Response regulator, receiver
HL650_RS19695	COG2205	protein histidine kinase activity
HL650_RS19705	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HL650_RS19710	COG0110	maltose O-acetyltransferase activity
HL650_RS19725	COG3835	regulator
HL650_RS19735	COG5012	cobalamin binding
HL650_RS19755	COG5012	cobalamin binding
HL650_RS19780	COG0395	ABC-type sugar transport system, permease component
HL650_RS19785	COG0366	Alpha amylase catalytic
HL650_RS19790	COG0673	inositol 2-dehydrogenase activity
HL650_RS19800	COG1940	carbohydrate kinase activity
HL650_RS19815	COG1175	transmembrane transport
HL650_RS19840	COG1175	transmembrane transport
HL650_RS19845	COG0395	ABC-type sugar transport system, permease component
HL650_RS19860	COG2207	Transcriptional regulator
HL650_RS19875	COG3944	biosynthesis protein
HL650_RS19895	COG4509	Sortase family
HL650_RS19905	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HL650_RS19920	COG0438	transferase activity, transferring glycosyl groups
HL650_RS19935	COG3475	LICD family
HL650_RS19945	COG1216	Glycosyl transferase, family 2
HL650_RS19950	COG0463	Glycosyl transferase, family 2
HL650_RS19950	COG1216	Glycosyl transferase, family 2
HL650_RS19960	COG1215	transferase activity, transferring glycosyl groups
HL650_RS19965	COG1216	Glycosyl transferase, family 2
HL650_RS19995	COG2207	Transcriptional regulator
HL650_RS20000	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HL650_RS20010	COG1486	melibiose metabolic process
HL650_RS20030	COG2207	Transcriptional regulator
HL650_RS20035	COG1486	melibiose metabolic process
HL650_RS20045	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HL650_RS20055	COG1213	nucleotidyl transferase
HL650_RS20060	COG4750	Nucleotidyl transferase
HL650_RS20070	COG2002	toxin-antitoxin pair type II binding
HL650_RS20075	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HL650_RS20080	COG1876	peptidase activity
HL650_RS20085	COG1737	Transcriptional regulator
HL650_RS20090	COG1063	alcohol dehydrogenase
HL650_RS20095	COG1830	Aldolase
HL650_RS20105	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HL650_RS20115	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HL650_RS20120	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HL650_RS20170	COG3279	Response regulator of the LytR AlgR family
HL650_RS20190	COG2996	Protein conserved in bacteria
HL650_RS20195	COG0500	methyltransferase
HL650_RS20210	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HL650_RS20215	COG0569	domain protein
HL650_RS20220	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HL650_RS20235	COG2205	protein histidine kinase activity
HL650_RS20240	COG2252	PERMEase
HL650_RS20245	COG1136	(ABC) transporter
HL650_RS20270	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HL650_RS20275	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HL650_RS20275	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HL650_RS20285	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HL650_RS20290	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HL650_RS20295	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HL650_RS20300	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HL650_RS20315	COG1192	Involved in chromosome partitioning
HL650_RS20320	COG1475	DNA binding
HL650_RS20355	COG1396	sequence-specific DNA binding
HL650_RS20360	COG1396	sequence-specific DNA binding
HL650_RS20440	COG0791	NLP P60 protein
HL650_RS20455	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HL650_RS20455	COG0551	DNA topoisomerase type I activity
HL650_RS20505	COG0641	radical SAM
HL650_RS20525	COG0745	RESPONSE REGULATOR receiver
HL650_RS20530	COG5002	protein histidine kinase activity
HL650_RS20530	COG0784	Response regulator, receiver
HL650_RS20540	COG1136	(ABC) transporter
HL650_RS20550	COG0517	IMP dehydrogenase activity
HL650_RS20555	COG4974	Belongs to the 'phage' integrase family
HL650_RS20675	COG3177	Filamentation induced by cAMP protein fic
HL650_RS20695	COG0681	Belongs to the peptidase S26 family
HL650_RS20705	COG4474	Belongs to the UPF0398 family
HL650_RS20750	COG0483	inositol monophosphate 1-phosphatase activity
HL650_RS20850	COG1136	(ABC) transporter
HL650_RS20855	COG5002	protein histidine kinase activity
HL650_RS20860	COG0745	RESPONSE REGULATOR receiver
HL650_RS20905	COG1309	transcriptional regulator
HL650_RS20925	COG0534	Mate efflux family protein
HL650_RS20965	COG1309	transcriptional regulator
HL650_RS20970	COG5504	Zn-dependent protease
HL650_RS20975	COG0789	Transcriptional regulator
HL650_RS20985	COG3969	phosphoadenosine phosphosulfate
HL650_RS20990	COG1475	DNA binding
HL650_RS20995	COG1404	Belongs to the peptidase S8 family
HL650_RS21000	COG1473	amidohydrolase
HL650_RS21005	COG1686	Belongs to the peptidase S11 family
HL650_RS21010	COG1331	Highly conserved protein containing a thioredoxin domain
HL650_RS21020	COG1175	transmembrane transport
HL650_RS21025	COG0395	ABC-type sugar transport system, permease component
HL650_RS21035	COG1609	Transcriptional regulator
HL650_RS21040	COG3940	Belongs to the glycosyl hydrolase 43 family
HL650_RS21080	COG1175	transmembrane transport
HL650_RS21085	COG0395	ABC-type sugar transport system, permease component
HL650_RS21090	COG3842	ATPase activity
HL650_RS21095	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HL650_RS21110	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HL650_RS21135	COG1609	Transcriptional regulator
HL650_RS21150	COG2205	protein histidine kinase activity
HL650_RS21150	COG0784	Response regulator, receiver
HL650_RS21155	COG3437	response regulator, receiver
HL650_RS21165	COG2205	protein histidine kinase activity
HL650_RS21165	COG5002	protein histidine kinase activity
HL650_RS21165	COG0784	Response regulator, receiver
HL650_RS21170	COG0745	RESPONSE REGULATOR receiver
HL650_RS21175	COG2205	protein histidine kinase activity
HL650_RS21180	COG1136	(ABC) transporter
HL650_RS21190	COG1595	DNA-templated transcription, initiation
HL650_RS21195	COG4978	Transcriptional regulator
HL650_RS21195	COG0789	Transcriptional regulator
HL650_RS21200	COG1720	tRNA m6t6A37 methyltransferase activity
HL650_RS21210	COG1917	Cupin 2, conserved barrel domain protein
HL650_RS21210	COG2207	Transcriptional regulator
HL650_RS21215	COG2378	regulation of single-species biofilm formation
HL650_RS21220	COG0745	RESPONSE REGULATOR receiver
HL650_RS21235	COG1686	Belongs to the peptidase S11 family
HL650_RS21240	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HL650_RS21245	COG1181	Belongs to the D-alanine--D-alanine ligase family
HL650_RS21260	COG2239	Acts as a magnesium transporter
HL650_RS21270	COG2205	protein histidine kinase activity
HL650_RS21275	COG0745	RESPONSE REGULATOR receiver
HL650_RS21300	COG1396	sequence-specific DNA binding
HL650_RS21330	COG2814	Major facilitator Superfamily
HL650_RS21335	COG0574	Belongs to the PEP-utilizing enzyme family
HL650_RS21335	COG3848	Pyruvate phosphate dikinase
HL650_RS21340	COG1309	transcriptional regulator
HL650_RS21350	COG4509	Sortase family
HL650_RS21375	COG1733	regulation of RNA biosynthetic process
HL650_RS21400	COG0534	Mate efflux family protein
HL650_RS21405	COG1937	Protein conserved in bacteria
HL650_RS21420	COG2217	Heavy metal translocating P-type atpase
HL650_RS21425	COG0640	Transcriptional regulator
HL650_RS21430	COG0640	Transcriptional regulator
HL650_RS21440	COG1733	regulation of RNA biosynthetic process
HL650_RS21470	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HL650_RS21560	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HL650_RS21615	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HL650_RS21685	COG1401	restriction endodeoxyribonuclease activity
HL650_RS21720	COG0745	RESPONSE REGULATOR receiver
HL650_RS21730	COG1136	(ABC) transporter
HL650_RS21745	COG4978	Transcriptional regulator
HL650_RS21745	COG0789	Transcriptional regulator
HL650_RS21770	COG1228	amidohydrolase
HL650_RS21785	COG0747	negative chemotaxis
HL650_RS21805	COG0444	Belongs to the ABC transporter superfamily
HL650_RS21810	COG4608	Belongs to the ABC transporter superfamily
HL650_RS21815	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HL650_RS21825	COG0346	lactoylglutathione lyase activity
HL650_RS21835	COG0395	ABC-type sugar transport system, permease component
HL650_RS21840	COG1175	transmembrane transport
HL650_RS21845	COG4221	oxidoreductase activity
HL650_RS21850	COG0673	inositol 2-dehydrogenase activity
HL650_RS21865	COG2723	6-phospho-beta-galactosidase activity
HL650_RS21870	COG1073	alpha beta
HL650_RS21895	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HL650_RS21905	COG0250	Participates in transcription elongation, termination and antitermination
HL650_RS21915	COG0081	regulation of translation
HL650_RS21920	COG3344	reverse transcriptase
HL650_RS21930	COG4974	Belongs to the 'phage' integrase family
HL650_RS21940	COG1388	LysM domain
HL650_RS21940	COG3858	chitin binding
HL650_RS21965	COG0222	ribosome binding
HL650_RS21970	COG3620	sequence-specific DNA binding
HL650_RS21980	COG0085	RNA polymerase activity
HL650_RS21985	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HL650_RS21995	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HL650_RS22000	COG0049	tRNA binding
HL650_RS22005	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HL650_RS22010	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HL650_RS22025	COG1193	negative regulation of DNA recombination
HL650_RS22040	COG3279	Response regulator of the LytR AlgR family
HL650_RS22045	COG1136	(ABC) transporter
HL650_RS22055	COG5002	protein histidine kinase activity
HL650_RS22060	COG0745	RESPONSE REGULATOR receiver
HL650_RS22070	COG4209	transmembrane transport
HL650_RS22075	COG0395	ABC-type sugar transport system, permease component
HL650_RS22090	COG0110	maltose O-acetyltransferase activity
HL650_RS22095	COG0534	Mate efflux family protein
HL650_RS22100	COG2207	Transcriptional regulator
HL650_RS22100	COG1917	Cupin 2, conserved barrel domain protein
HL650_RS22110	COG1695	Transcriptional regulator
HL650_RS22120	COG2222	sugar isomerase
HL650_RS22125	COG1609	Transcriptional regulator
HL650_RS22130	COG3250	beta-galactosidase activity
HL650_RS22140	COG0395	ABC-type sugar transport system, permease component
HL650_RS22145	COG1653	transport
HL650_RS22150	COG0534	Mate efflux family protein
HL650_RS22165	COG1609	Transcriptional regulator
HL650_RS22190	COG3655	Transcriptional regulator
HL650_RS22200	COG0745	RESPONSE REGULATOR receiver
HL650_RS22210	COG0577	efflux transmembrane transporter activity
HL650_RS22210	COG1136	(ABC) transporter
HL650_RS22225	COG1595	DNA-templated transcription, initiation
HL650_RS22235	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HL650_RS22240	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HL650_RS22250	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HL650_RS22255	COG3958	Transketolase
HL650_RS22260	COG1028	Short-chain dehydrogenase reductase Sdr
HL650_RS22275	COG5001	Diguanylate cyclase
HL650_RS22295	COG1509	lysine 2,3-aminomutase activity
HL650_RS22310	COG1151	hydroxylamine reductase activity
HL650_RS22325	COG1966	Carbon starvation protein
HL650_RS22330	COG0457	Tetratricopeptide repeat
HL650_RS22375	COG0657	acetylesterase activity
HL650_RS22390	COG3426	butyrate kinase activity
HL650_RS22405	COG2197	response regulator
HL650_RS22410	COG2972	Histidine kinase
HL650_RS22430	COG0395	ABC-type sugar transport system, permease component
HL650_RS22435	COG3250	beta-galactosidase activity
HL650_RS22440	COG2205	protein histidine kinase activity
HL650_RS22455	COG0252	asparaginase activity
HL650_RS22470	COG3850	Histidine kinase
HL650_RS22470	COG5002	protein histidine kinase activity
HL650_RS22480	COG0116	Belongs to the methyltransferase superfamily
HL650_RS22480	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HL650_RS22490	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HL650_RS22510	COG2207	Transcriptional regulator
HL650_RS22520	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HL650_RS22525	COG0582	viral genome integration into host DNA
HL650_RS22540	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HL650_RS22545	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HL650_RS22550	COG0456	acetyltransferase
HL650_RS22560	COG1181	Belongs to the D-alanine--D-alanine ligase family
HL650_RS22575	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HL650_RS22580	COG0110	maltose O-acetyltransferase activity
HL650_RS22655	COG3842	ATPase activity
HL650_RS22685	COG1518	maintenance of DNA repeat elements
HL650_RS22690	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HL650_RS22695	COG0534	Mate efflux family protein
HL650_RS22705	COG0534	Mate efflux family protein
HL650_RS22720	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HL650_RS22725	COG1802	Transcriptional regulator
HL650_RS22730	COG0697	spore germination
HL650_RS22745	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HL650_RS22760	COG0544	peptidyl-prolyl cis-trans isomerase activity
HL650_RS22765	COG0768	penicillin binding
HL650_RS22800	COG2972	Histidine kinase
HL650_RS22805	COG4753	response regulator
HL650_RS22805	COG2207	Transcriptional regulator
HL650_RS22815	COG1175	transmembrane transport
HL650_RS22820	COG0395	ABC-type sugar transport system, permease component
HL650_RS22825	COG0445	tRNA wobble uridine modification
HL650_RS22840	COG0017	Asparaginyl-tRNA synthetase
HL650_RS22865	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HL650_RS22885	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HL650_RS22890	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HL650_RS22895	COG2088	sporulation resulting in formation of a cellular spore
HL650_RS22915	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
HL650_RS22915	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HL650_RS22920	COG1609	Transcriptional regulator
HL650_RS22955	COG0590	tRNA wobble adenosine to inosine editing
HL650_RS22960	COG0646	methionine synthase
HL650_RS22960	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HL650_RS22965	COG0586	Pfam SNARE associated Golgi protein
HL650_RS22980	COG0205	6-phosphofructokinase activity
HL650_RS22985	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HL650_RS22990	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HL650_RS22995	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HL650_RS23000	COG1609	Transcriptional regulator
HL650_RS23010	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HL650_RS23015	COG3958	Transketolase
HL650_RS23055	COG1175	transmembrane transport
HL650_RS23060	COG0395	ABC-type sugar transport system, permease component
HL650_RS23065	COG0366	Alpha amylase catalytic
HL650_RS23125	COG0745	RESPONSE REGULATOR receiver
HL650_RS23130	COG2205	protein histidine kinase activity
HL650_RS23135	COG0039	L-malate dehydrogenase activity
HL650_RS23150	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
HL650_RS23180	COG1053	succinate dehydrogenase
HL650_RS23185	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HL650_RS23215	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HL650_RS23290	COG0582	viral genome integration into host DNA
HL650_RS23325	COG0710	3-dehydroquinate dehydratase activity
HL650_RS23355	COG1472	Belongs to the glycosyl hydrolase 3 family
HL650_RS23360	COG3275	phosphorelay sensor kinase activity
HL650_RS23365	COG4753	response regulator
HL650_RS23365	COG2207	Transcriptional regulator
HL650_RS23380	COG4209	transmembrane transport
HL650_RS23385	COG0395	ABC-type sugar transport system, permease component
HL650_RS23455	COG5492	domain, Protein
HL650_RS23455	COG4932	domain protein
HL650_RS23470	COG2204	response regulator
HL650_RS23475	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HL650_RS23490	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HL650_RS23495	COG1454	alcohol dehydrogenase
HL650_RS23500	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HL650_RS23510	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HL650_RS23555	COG2003	Belongs to the UPF0758 family
HL650_RS23580	COG0741	lytic transglycosylase activity
HL650_RS23580	COG0791	NLP P60 protein
HL650_RS23630	COG1192	Involved in chromosome partitioning
HL650_RS23660	COG3250	beta-galactosidase activity
HL650_RS23665	COG1063	alcohol dehydrogenase
HL650_RS23670	COG0656	L-ascorbic acid biosynthetic process
HL650_RS23700	COG3300	MHYT domain
HL650_RS23700	COG5001	Diguanylate cyclase
HL650_RS23715	COG0246	Mannitol dehydrogenase
HL650_RS23720	COG1312	Catalyzes the dehydration of D-mannonate
HL650_RS23725	COG3708	Transcriptional regulator
HL650_RS23725	COG2207	Transcriptional regulator
HL650_RS23740	COG0583	DNA-binding transcription factor activity
HL650_RS23745	COG2855	membrane
HL650_RS23755	COG1528	Iron-storage protein
HL650_RS23765	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HL650_RS23785	COG1511	domain protein
HL650_RS23810	COG1994	Peptidase M50
HL650_RS23820	COG1522	sequence-specific DNA binding
HL650_RS23825	COG0179	Fumarylacetoacetate (FAA) hydrolase
HL650_RS23850	COG1288	antiporter activity
HL650_RS23855	COG3940	Belongs to the glycosyl hydrolase 43 family
HL650_RS23865	COG3534	alpha-L-arabinofuranosidase
HL650_RS23875	COG1653	transport
HL650_RS23880	COG1175	transmembrane transport
HL650_RS23885	COG0395	ABC-type sugar transport system, permease component
HL650_RS23890	COG3534	alpha-L-arabinofuranosidase
HL650_RS23895	COG0534	Mate efflux family protein
HL650_RS23905	COG1691	(AIR) carboxylase
HL650_RS23915	COG0534	Mate efflux family protein
HL650_RS23930	COG2080	2 iron, 2 sulfur cluster binding
HL650_RS23930	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HL650_RS23935	COG0531	amino acid
HL650_RS23940	COG1362	aminopeptidase activity
HL650_RS23970	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HL650_RS23975	COG0531	amino acid
HL650_RS23985	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
HL650_RS23990	COG0437	4 iron, 4 sulfur cluster binding
HL650_RS23990	COG3064	Membrane
HL650_RS24010	COG0791	NLP P60 protein
HL650_RS24025	COG0426	domain, Protein
HL650_RS24030	COG1501	Belongs to the glycosyl hydrolase 31 family
HL650_RS24045	COG1472	Belongs to the glycosyl hydrolase 3 family
HL650_RS24050	COG4209	transmembrane transport
HL650_RS24055	COG0395	ABC-type sugar transport system, permease component
HL650_RS24065	COG2207	Transcriptional regulator
HL650_RS24065	COG4753	response regulator
HL650_RS24085	COG0657	acetylesterase activity
HL650_RS24085	COG2755	lipolytic protein G-D-S-L family
HL650_RS24095	COG4209	transmembrane transport
HL650_RS24100	COG0395	ABC-type sugar transport system, permease component
HL650_RS24105	COG3275	phosphorelay sensor kinase activity
HL650_RS24125	COG2226	methyltransferase
HL650_RS24130	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HL650_RS24185	COG0561	phosphatase activity
HL650_RS24190	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
HL650_RS24205	COG1115	amino acid carrier protein
HL650_RS24215	COG3290	protein histidine kinase activity
HL650_RS24225	COG1132	(ABC) transporter
HL650_RS24250	COG1983	PspC domain protein
HL650_RS24255	COG2340	Cysteine-rich secretory protein family
HL650_RS24315	COG2378	regulation of single-species biofilm formation
HL650_RS24345	COG2972	Histidine kinase
HL650_RS24350	COG2207	Transcriptional regulator
HL650_RS24350	COG4753	response regulator
HL650_RS24360	COG4753	response regulator
HL650_RS24360	COG2207	Transcriptional regulator
HL650_RS24365	COG2972	Histidine kinase
HL650_RS24380	COG1796	DNA polymerase
HL650_RS24380	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HL650_RS24390	COG4209	transmembrane transport
HL650_RS24400	COG0395	ABC-type sugar transport system, permease component
HL650_RS24405	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HL650_RS24410	COG1486	melibiose metabolic process
HL650_RS24420	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HL650_RS24435	COG4209	transmembrane transport
HL650_RS24440	COG0395	ABC-type sugar transport system, permease component
HL650_RS24455	COG3250	beta-galactosidase activity
HL650_RS24460	COG2357	RelA SpoT domain protein
HL650_RS24480	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HL650_RS24495	COG1481	regulation of sporulation
HL650_RS24500	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HL650_RS24510	COG2160	L-arabinose isomerase activity
HL650_RS24525	COG2972	Histidine kinase
HL650_RS24540	COG1653	transport
HL650_RS24545	COG1175	transmembrane transport
HL650_RS24555	COG0383	alpha-mannosidase activity
HL650_RS24560	COG1362	aminopeptidase activity
HL650_RS24575	COG0051	transcription antitermination factor activity, RNA binding
HL650_RS24580	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HL650_RS24595	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HL650_RS24605	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HL650_RS24615	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HL650_RS24620	COG0255	Belongs to the universal ribosomal protein uL29 family
HL650_RS24625	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HL650_RS24645	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HL650_RS24650	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HL650_RS24655	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HL650_RS24665	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HL650_RS24675	COG0200	Binds to the 23S rRNA
HL650_RS24685	COG0563	adenylate kinase activity
HL650_RS24700	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HL650_RS24705	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HL650_RS24710	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HL650_RS24715	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HL650_RS24720	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HL650_RS24725	COG0202	RNA polymerase activity
HL650_RS24730	COG0203	ribosomal protein L17
HL650_RS24735	COG1597	lipid kinase activity
HL650_RS24760	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HL650_RS24765	COG0840	transmembrane signaling receptor activity
HL650_RS24775	COG0840	transmembrane signaling receptor activity
HL650_RS24785	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HL650_RS24815	COG3835	regulator
HL650_RS24820	COG2884	Cell division ATP-binding protein ftsE
HL650_RS24825	COG2177	Part of the ABC transporter FtsEX involved in
HL650_RS24830	COG0793	Belongs to the peptidase S41A family
HL650_RS24840	COG3437	response regulator, receiver
HL650_RS24850	COG1070	Carbohydrate kinase
HL650_RS24855	COG4806	L-rhamnose isomerase
HL650_RS24860	COG0235	Class ii aldolase
HL650_RS24865	COG2169	Transcriptional regulator
HL650_RS24870	COG1082	Xylose isomerase domain protein TIM barrel
HL650_RS24875	COG0673	inositol 2-dehydrogenase activity
HL650_RS24890	COG5002	protein histidine kinase activity
HL650_RS24890	COG2205	protein histidine kinase activity
HL650_RS24890	COG0784	Response regulator, receiver
HL650_RS25010	COG1757	Na H antiporter
HL650_RS25020	COG1420	regulation of RNA biosynthetic process
HL650_RS25025	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HL650_RS25030	COG0443	Heat shock 70 kDa protein
HL650_RS25035	COG0484	heat shock protein binding
HL650_RS25080	COG2264	protein methyltransferase activity
HL650_RS25085	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HL650_RS25090	COG1104	cysteine desulfurase activity
HL650_RS25095	COG0301	tRNA thio-modification
HL650_RS25105	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HL650_RS25110	COG4472	Bacterial protein of unknown function (DUF965)
HL650_RS25125	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HL650_RS25160	COG2207	Transcriptional regulator
HL650_RS25170	COG0758	DNA mediated transformation
HL650_RS25175	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HL650_RS25185	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HL650_RS25190	COG0459	protein refolding
HL650_RS25200	COG0517	IMP dehydrogenase activity
HL650_RS25200	COG0516	GMP reductase activity
HL650_RS25215	COG4753	response regulator
HL650_RS25215	COG2207	Transcriptional regulator
HL650_RS25230	COG0395	ABC-type sugar transport system, permease component
HL650_RS25250	COG1501	Belongs to the glycosyl hydrolase 31 family
HL650_RS25260	COG1131	(ABC) transporter
HL650_RS25265	COG1725	Transcriptional regulator
HL650_RS25285	COG1396	sequence-specific DNA binding
HL650_RS25305	COG3870	Protein conserved in bacteria
HL650_RS25310	COG1811	Na channel or pump
HL650_RS25330	COG1744	ABC transporter substrate-binding protein PnrA-like
HL650_RS25345	COG1079	Belongs to the binding-protein-dependent transport system permease family
HL650_RS25360	COG0733	neurotransmitter:sodium symporter activity
HL650_RS25380	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HL650_RS25390	COG3853	Toxic anion resistance protein (TelA)
HL650_RS25395	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HL650_RS25405	COG0285	dihydrofolate synthase activity
HL650_RS25410	COG0302	gtp cyclohydrolase
HL650_RS25415	COG1418	mRNA catabolic process
HL650_RS25420	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HL650_RS25425	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HL650_RS25425	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HL650_RS25450	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HL650_RS25455	COG0165	Argininosuccinate lyase
HL650_RS25470	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HL650_RS25485	COG0583	DNA-binding transcription factor activity
HL650_RS25490	COG2986	histidine ammonia-lyase
HL650_RS25495	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HL650_RS25525	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HL650_RS25560	COG2264	protein methyltransferase activity
HL650_RS25570	COG0673	inositol 2-dehydrogenase activity
HL650_RS25575	COG1082	Xylose isomerase domain protein TIM barrel
HL650_RS25580	COG1082	Xylose isomerase domain protein TIM barrel
HL650_RS25595	COG2207	Transcriptional regulator
HL650_RS25595	COG4753	response regulator
HL650_RS25600	COG2972	Histidine kinase
HL650_RS25605	COG1653	transport
HL650_RS25610	COG1175	transmembrane transport
HL650_RS25615	COG0395	ABC-type sugar transport system, permease component
HL650_RS25625	COG3250	beta-galactosidase activity
HL650_RS25630	COG4753	response regulator
HL650_RS25630	COG2207	Transcriptional regulator
HL650_RS25635	COG1609	Transcriptional regulator
HL650_RS25640	COG1653	transport
HL650_RS25645	COG1175	transmembrane transport
HL650_RS25650	COG0395	ABC-type sugar transport system, permease component
HL650_RS25655	COG3507	Belongs to the glycosyl hydrolase 43 family
HL650_RS25680	COG2207	Transcriptional regulator
HL650_RS25680	COG4753	response regulator
HL650_RS25700	COG0653	protein targeting
HL650_RS25715	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HL650_RS25725	COG0733	neurotransmitter:sodium symporter activity
HL650_RS25750	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HL650_RS25760	COG0726	polysaccharide deacetylase
HL650_RS25765	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HL650_RS25775	COG1242	4 iron, 4 sulfur cluster binding
HL650_RS25800	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HL650_RS25805	COG4496	protein, YerC YecD
HL650_RS25835	COG1395	domain, Protein
HL650_RS25905	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HL650_RS25950	COG3561	AntA/AntB antirepressor
HL650_RS25990	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HL650_RS26010	COG1309	transcriptional regulator
HL650_RS26020	COG0519	Catalyzes the synthesis of GMP from XMP
HL650_RS26040	COG4555	ABC transporter
HL650_RS26075	COG0534	Mate efflux family protein
HL650_RS26090	COG0513	Belongs to the DEAD box helicase family
HL650_RS26100	COG1917	Cupin 2, conserved barrel domain protein
HL650_RS26100	COG2207	Transcriptional regulator
HL650_RS26105	COG0110	maltose O-acetyltransferase activity
HL650_RS26110	COG0534	Mate efflux family protein
HL650_RS26125	COG1063	alcohol dehydrogenase