locus-tag	class	description
A4V09_RS00020	COG3250	beta-galactosidase activity
A4V09_RS00030	COG4209	transmembrane transport
A4V09_RS00035	COG0395	ABC-type sugar transport system, permease component
A4V09_RS00060	COG3275	phosphorelay sensor kinase activity
A4V09_RS00065	COG4753	response regulator
A4V09_RS00065	COG2207	Transcriptional regulator
A4V09_RS00080	COG1175	transmembrane transport
A4V09_RS00085	COG0395	ABC-type sugar transport system, permease component
A4V09_RS00130	COG2706	6-phosphogluconolactonase activity
A4V09_RS00135	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
A4V09_RS00140	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A4V09_RS00145	COG3620	sequence-specific DNA binding
A4V09_RS00160	COG1121	(ABC) transporter
A4V09_RS00170	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
A4V09_RS00180	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
A4V09_RS00185	COG1687	branched-chain amino acid
A4V09_RS00205	COG2252	PERMEase
A4V09_RS00210	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
A4V09_RS00215	COG0431	NADPH-dependent FMN reductase
A4V09_RS00225	COG0789	Transcriptional regulator
A4V09_RS00230	COG0582	viral genome integration into host DNA
A4V09_RS00235	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A4V09_RS00240	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A4V09_RS00245	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A4V09_RS00280	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
A4V09_RS00285	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
A4V09_RS00290	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
A4V09_RS00295	COG2205	protein histidine kinase activity
A4V09_RS00370	COG0534	Mate efflux family protein
A4V09_RS00375	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A4V09_RS00385	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
A4V09_RS00395	COG0157	Belongs to the NadC ModD family
A4V09_RS00400	COG1827	regulation of RNA biosynthetic process
A4V09_RS00405	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A4V09_RS00435	COG0456	acetyltransferase
A4V09_RS00440	COG1283	sodium-dependent phosphate transmembrane transporter activity
A4V09_RS00450	COG5002	protein histidine kinase activity
A4V09_RS00475	COG3546	catalase activity
A4V09_RS00485	COG0569	domain protein
A4V09_RS00495	COG2217	Heavy metal translocating P-type atpase
A4V09_RS00510	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
A4V09_RS00520	COG1476	TRANSCRIPTIONal
A4V09_RS00530	COG4152	abc transporter atp-binding protein
A4V09_RS00535	COG1668	transmembrane transport
A4V09_RS00540	COG0363	glucosamine-6-phosphate deaminase activity
A4V09_RS00850	COG3646	Phage regulatory protein
A4V09_RS00890	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A4V09_RS00895	COG4868	Belongs to the UPF0371 family
A4V09_RS00900	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A4V09_RS00905	COG0322	excinuclease ABC activity
A4V09_RS00910	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
A4V09_RS00915	COG1940	carbohydrate kinase activity
A4V09_RS00925	COG1739	Uncharacterized protein family UPF0029
A4V09_RS00930	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A4V09_RS00935	COG0802	atpase or kinase
A4V09_RS00940	COG1214	PFAM Peptidase M22, glycoprotease
A4V09_RS00945	COG0456	acetyltransferase
A4V09_RS00955	COG1234	tRNA 3'-trailer cleavage
A4V09_RS00965	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
A4V09_RS01030	COG0242	peptide deformylase activity
A4V09_RS01045	COG0745	RESPONSE REGULATOR receiver
A4V09_RS01060	COG2205	protein histidine kinase activity
A4V09_RS01100	COG2508	Transcriptional regulator
A4V09_RS01100	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
A4V09_RS01120	COG5002	protein histidine kinase activity
A4V09_RS01155	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A4V09_RS01170	COG1131	(ABC) transporter
A4V09_RS01205	COG1131	(ABC) transporter
A4V09_RS01230	COG1131	(ABC) transporter
A4V09_RS01245	COG2207	Transcriptional regulator
A4V09_RS01250	COG5012	cobalamin binding
A4V09_RS01255	COG5598	trimethylamine methyltransferase
A4V09_RS01280	COG2738	Putative neutral zinc metallopeptidase
A4V09_RS01315	COG1609	Transcriptional regulator
A4V09_RS01325	COG1175	transmembrane transport
A4V09_RS01330	COG0395	ABC-type sugar transport system, permease component
A4V09_RS01350	COG1879	ABC-type sugar transport system periplasmic component
A4V09_RS01355	COG1129	ABC transporter
A4V09_RS01360	COG4211	Belongs to the binding-protein-dependent transport system permease family
A4V09_RS01365	COG4753	response regulator
A4V09_RS01365	COG2207	Transcriptional regulator
A4V09_RS01370	COG2972	Histidine kinase
A4V09_RS01390	COG1136	(ABC) transporter
A4V09_RS01405	COG1609	Transcriptional regulator
A4V09_RS01410	COG0673	inositol 2-dehydrogenase activity
A4V09_RS01425	COG1082	Xylose isomerase domain protein TIM barrel
A4V09_RS01430	COG1082	Xylose isomerase domain protein TIM barrel
A4V09_RS01450	COG1131	(ABC) transporter
A4V09_RS01485	COG1720	tRNA m6t6A37 methyltransferase activity
A4V09_RS01490	COG0367	asparagine synthase
A4V09_RS01495	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A4V09_RS01510	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
A4V09_RS01515	COG2207	Transcriptional regulator
A4V09_RS01515	COG3708	Transcriptional regulator
A4V09_RS01535	COG3250	beta-galactosidase activity
A4V09_RS01540	COG1874	Beta-galactosidase
A4V09_RS01550	COG1380	Effector of murein hydrolase LrgA
A4V09_RS01555	COG1346	cytolysis
A4V09_RS01575	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A4V09_RS01595	COG1175	transmembrane transport
A4V09_RS01600	COG0395	ABC-type sugar transport system, permease component
A4V09_RS01620	COG3959	Transketolase, thiamine diphosphate binding domain
A4V09_RS01625	COG3958	Transketolase
A4V09_RS01630	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A4V09_RS01655	COG1132	(ABC) transporter
A4V09_RS01660	COG1132	(ABC) transporter
A4V09_RS01665	COG4251	negative regulation of phosphorylation
A4V09_RS01665	COG2203	Gaf domain
A4V09_RS01665	COG3706	GGDEF domain
A4V09_RS01665	COG5001	Diguanylate cyclase
A4V09_RS01670	COG0582	viral genome integration into host DNA
A4V09_RS01680	COG0686	Belongs to the AlaDH PNT family
A4V09_RS01685	COG1115	amino acid carrier protein
A4V09_RS01690	COG4974	Belongs to the 'phage' integrase family
A4V09_RS01710	COG4536	flavin adenine dinucleotide binding
A4V09_RS01715	COG1408	metallophosphoesterase
A4V09_RS01725	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
A4V09_RS01735	COG1136	(ABC) transporter
A4V09_RS01745	COG0745	RESPONSE REGULATOR receiver
A4V09_RS01750	COG0642	Histidine kinase
A4V09_RS01755	COG1671	Belongs to the UPF0178 family
A4V09_RS01760	COG2205	protein histidine kinase activity
A4V09_RS01760	COG0784	Response regulator, receiver
A4V09_RS01760	COG5002	protein histidine kinase activity
A4V09_RS01770	COG2188	Transcriptional regulator
A4V09_RS01780	COG0110	maltose O-acetyltransferase activity
A4V09_RS01825	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
A4V09_RS01835	COG1268	BioY protein
A4V09_RS01840	COG4566	intracellular signal transduction
A4V09_RS01840	COG0745	RESPONSE REGULATOR receiver
A4V09_RS01875	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A4V09_RS01880	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A4V09_RS01885	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A4V09_RS01890	COG0151	Belongs to the GarS family
A4V09_RS01900	COG0110	maltose O-acetyltransferase activity
A4V09_RS01915	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
A4V09_RS01940	COG1086	Polysaccharide biosynthesis protein
A4V09_RS01950	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
A4V09_RS01965	COG3314	Sporulation integral membrane protein YlbJ
A4V09_RS01970	COG2986	histidine ammonia-lyase
A4V09_RS01980	COG2972	Histidine kinase
A4V09_RS01985	COG4753	response regulator
A4V09_RS01985	COG2207	Transcriptional regulator
A4V09_RS01990	COG1653	transport
A4V09_RS01995	COG1175	transmembrane transport
A4V09_RS02000	COG0395	ABC-type sugar transport system, permease component
A4V09_RS02030	COG0275	rRNA processing
A4V09_RS02035	COG0322	excinuclease ABC activity
A4V09_RS02040	COG3664	PFAM glycoside hydrolase family 39
A4V09_RS02045	COG2211	Major facilitator Superfamily
A4V09_RS02050	COG0673	inositol 2-dehydrogenase activity
A4V09_RS02075	COG0673	inositol 2-dehydrogenase activity
A4V09_RS02080	COG0110	maltose O-acetyltransferase activity
A4V09_RS02090	COG0366	Alpha amylase catalytic
A4V09_RS02100	COG1472	Belongs to the glycosyl hydrolase 3 family
A4V09_RS02115	COG4509	Sortase family
A4V09_RS02130	COG0360	Binds together with S18 to 16S ribosomal RNA
A4V09_RS02135	COG0629	single-stranded DNA binding
A4V09_RS02140	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A4V09_RS02155	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
A4V09_RS02160	COG0359	binds to the 23S rRNA
A4V09_RS02165	COG0305	Participates in initiation and elongation during chromosome replication
A4V09_RS02205	COG1459	type II secretion system
A4V09_RS02215	COG0322	excinuclease ABC activity
A4V09_RS02220	COG0745	RESPONSE REGULATOR receiver
A4V09_RS02225	COG5002	protein histidine kinase activity
A4V09_RS02245	COG0268	Binds directly to 16S ribosomal RNA
A4V09_RS02250	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
A4V09_RS02260	COG0481	GTPase activity
A4V09_RS02265	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A4V09_RS02285	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A4V09_RS02290	COG1040	competence protein
A4V09_RS02305	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
A4V09_RS02330	COG1376	ErfK ybiS ycfS ynhG family protein
A4V09_RS02335	COG0151	Belongs to the GarS family
A4V09_RS02345	COG0463	Glycosyl transferase, family 2
A4V09_RS02360	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A4V09_RS02375	COG1442	glycosyl transferase family 8
A4V09_RS02380	COG0562	UDP-galactopyranose mutase
A4V09_RS02385	COG3475	LICD family
A4V09_RS02415	COG1686	Belongs to the peptidase S11 family
A4V09_RS02420	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
A4V09_RS02425	COG1682	transport, permease protein
A4V09_RS02450	COG1216	Glycosyl transferase, family 2
A4V09_RS02450	COG0438	transferase activity, transferring glycosyl groups
A4V09_RS02465	COG1216	Glycosyl transferase, family 2
A4V09_RS02465	COG0438	transferase activity, transferring glycosyl groups
A4V09_RS02470	COG1216	Glycosyl transferase, family 2
A4V09_RS02480	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A4V09_RS02480	COG0463	Glycosyl transferase, family 2
A4V09_RS02485	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A4V09_RS02490	COG0463	Glycosyl transferase, family 2
A4V09_RS02495	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A4V09_RS02505	COG1134	teichoic acid transport
A4V09_RS02510	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A4V09_RS02555	COG1968	undecaprenyl-diphosphatase activity
A4V09_RS02560	COG0446	pyridine nucleotide-disulphide oxidoreductase
A4V09_RS02560	COG1902	pentaerythritol trinitrate reductase activity
A4V09_RS02580	COG0549	Belongs to the carbamate kinase family
A4V09_RS02585	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A4V09_RS02590	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A4V09_RS02610	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A4V09_RS02615	COG0631	protein serine/threonine phosphatase activity
A4V09_RS02620	COG0515	serine threonine protein kinase
A4V09_RS02620	COG2815	serine threonine protein kinase
A4V09_RS02630	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A4V09_RS02635	COG1564	THIamine pyrophosphokinase
A4V09_RS02640	COG0012	GTP binding
A4V09_RS02650	COG2001	Belongs to the MraZ family
A4V09_RS02665	COG0768	penicillin binding
A4V09_RS02670	COG0768	penicillin binding
A4V09_RS02680	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A4V09_RS02685	COG0772	Belongs to the SEDS family
A4V09_RS02690	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A4V09_RS02710	COG0521	Mo-molybdopterin cofactor biosynthetic process
A4V09_RS02725	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A4V09_RS02730	COG0710	3-dehydroquinate dehydratase activity
A4V09_RS02740	COG1191	sigma factor activity
A4V09_RS02745	COG1414	Transcriptional regulator
A4V09_RS02750	COG0800	Aldolase
A4V09_RS02760	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A4V09_RS02775	COG3534	alpha-L-arabinofuranosidase
A4V09_RS02780	COG1968	undecaprenyl-diphosphatase activity
A4V09_RS02790	COG1191	sigma factor activity
A4V09_RS02805	COG1363	Peptidase, m42
A4V09_RS02810	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
A4V09_RS02820	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A4V09_RS02835	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A4V09_RS02840	COG0444	Belongs to the ABC transporter superfamily
A4V09_RS02845	COG4608	Belongs to the ABC transporter superfamily
A4V09_RS02850	COG0436	Aminotransferase
A4V09_RS02855	COG0534	Mate efflux family protein
A4V09_RS02870	COG1132	(ABC) transporter
A4V09_RS02880	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
A4V09_RS02890	COG0640	Transcriptional regulator
A4V09_RS02895	COG0372	Belongs to the citrate synthase family
A4V09_RS02900	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
A4V09_RS02945	COG1187	pseudouridine synthase activity
A4V09_RS02950	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A4V09_RS02955	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A4V09_RS02960	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
A4V09_RS02980	COG1396	sequence-specific DNA binding
A4V09_RS02990	COG0464	growth
A4V09_RS03080	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A4V09_RS03085	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A4V09_RS03105	COG1846	Transcriptional regulator
A4V09_RS03120	COG0583	DNA-binding transcription factor activity
A4V09_RS03125	COG0019	diaminopimelate decarboxylase activity
A4V09_RS03130	COG0488	(ABC) transporter
A4V09_RS03135	COG1959	2 iron, 2 sulfur cluster binding
A4V09_RS03150	COG0584	glycerophosphoryl diester phosphodiesterase
A4V09_RS03170	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A4V09_RS03175	COG1381	Involved in DNA repair and RecF pathway recombination
A4V09_RS03180	COG0423	glycine-tRNA ligase activity
A4V09_RS03185	COG1609	Transcriptional regulator
A4V09_RS03190	COG1621	beta-fructofuranosidase activity
A4V09_RS03195	COG1653	transport
A4V09_RS03200	COG1175	transmembrane transport
A4V09_RS03205	COG0395	ABC-type sugar transport system, permease component
A4V09_RS03220	COG2972	Histidine kinase
A4V09_RS03230	COG1653	transport
A4V09_RS03235	COG1175	transmembrane transport
A4V09_RS03240	COG0395	ABC-type sugar transport system, permease component
A4V09_RS03245	COG2207	Transcriptional regulator
A4V09_RS03245	COG4753	response regulator
A4V09_RS03250	COG3681	Belongs to the UPF0597 family
A4V09_RS03265	COG4989	oxidoreductase activity
A4V09_RS03270	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A4V09_RS03270	COG0574	Belongs to the PEP-utilizing enzyme family
A4V09_RS03275	COG1917	Cupin 2, conserved barrel domain protein
A4V09_RS03275	COG4977	sequence-specific DNA binding
A4V09_RS03300	COG0688	phosphatidylethanolamine metabolic process
A4V09_RS03310	COG1285	pathogenesis
A4V09_RS03320	COG2378	regulation of single-species biofilm formation
A4V09_RS03330	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A4V09_RS03340	COG0513	Belongs to the DEAD box helicase family
A4V09_RS03345	COG1501	Belongs to the glycosyl hydrolase 31 family
A4V09_RS03355	COG0656	L-ascorbic acid biosynthetic process
A4V09_RS03360	COG1979	alcohol dehydrogenase
A4V09_RS03370	COG2032	superoxide dismutase activity
A4V09_RS03385	COG1940	carbohydrate kinase activity
A4V09_RS03395	COG0613	PHP domain protein
A4V09_RS03405	COG2207	Transcriptional regulator
A4V09_RS03405	COG1917	Cupin 2, conserved barrel domain protein
A4V09_RS03425	COG2217	Heavy metal translocating P-type atpase
A4V09_RS03430	COG2186	Transcriptional regulator
A4V09_RS03440	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A4V09_RS03450	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
A4V09_RS03450	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
A4V09_RS03455	COG1063	alcohol dehydrogenase
A4V09_RS03460	COG1028	Short-chain dehydrogenase reductase Sdr
A4V09_RS03485	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
A4V09_RS03500	COG0584	glycerophosphoryl diester phosphodiesterase
A4V09_RS03505	COG0772	Belongs to the SEDS family
A4V09_RS03510	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A4V09_RS03515	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A4V09_RS03525	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A4V09_RS03530	COG0511	ligase activity, forming carbon-carbon bonds
A4V09_RS03535	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A4V09_RS03540	COG0439	Biotin carboxylase
A4V09_RS03550	COG2070	2-Nitropropane dioxygenase
A4V09_RS03570	COG4753	response regulator
A4V09_RS03570	COG2207	Transcriptional regulator
A4V09_RS03575	COG2972	Histidine kinase
A4V09_RS03580	COG1175	transmembrane transport
A4V09_RS03585	COG0395	ABC-type sugar transport system, permease component
A4V09_RS03590	COG1501	Belongs to the glycosyl hydrolase 31 family
A4V09_RS03605	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A4V09_RS03610	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
A4V09_RS03615	COG2080	2 iron, 2 sulfur cluster binding
A4V09_RS03625	COG1653	transport
A4V09_RS03635	COG0395	ABC-type sugar transport system, permease component
A4V09_RS03650	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A4V09_RS03655	COG0210	DNA helicase
A4V09_RS03665	COG0667	Aldo Keto reductase
A4V09_RS03670	COG0789	Transcriptional regulator
A4V09_RS03670	COG4978	Transcriptional regulator
A4V09_RS03680	COG1609	Transcriptional regulator
A4V09_RS03680	COG2207	Transcriptional regulator
A4V09_RS03695	COG3854	ATPases associated with a variety of cellular activities
A4V09_RS03735	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
A4V09_RS03745	COG1302	Protein conserved in bacteria
A4V09_RS03750	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A4V09_RS03755	COG1570	exodeoxyribonuclease VII activity
A4V09_RS03760	COG1722	exodeoxyribonuclease VII activity
A4V09_RS03770	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A4V09_RS03775	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
A4V09_RS03780	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A4V09_RS03785	COG1438	arginine binding
A4V09_RS03790	COG0497	DNA recombination
A4V09_RS03795	COG0750	zinc metalloprotease
A4V09_RS03800	COG0745	RESPONSE REGULATOR receiver
A4V09_RS03805	COG0297	glycogen (starch) synthase activity
A4V09_RS03810	COG0745	RESPONSE REGULATOR receiver
A4V09_RS03815	COG5002	protein histidine kinase activity
A4V09_RS03825	COG1136	(ABC) transporter
A4V09_RS03845	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
A4V09_RS03855	COG1418	mRNA catabolic process
A4V09_RS03870	COG4974	Belongs to the 'phage' integrase family
A4V09_RS03875	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A4V09_RS03895	COG2244	polysaccharide biosynthetic process
A4V09_RS03900	COG1959	2 iron, 2 sulfur cluster binding
A4V09_RS03910	COG0822	iron-sulfur transferase activity
A4V09_RS03915	COG0482	sulfurtransferase activity
A4V09_RS03920	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
A4V09_RS03935	COG0149	triose-phosphate isomerase activity
A4V09_RS03950	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4V09_RS03955	COG0765	amino acid transport
A4V09_RS03960	COG1126	abc transporter atp-binding protein
A4V09_RS03965	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
A4V09_RS03970	COG4977	sequence-specific DNA binding
A4V09_RS04005	COG0148	phosphopyruvate hydratase activity
A4V09_RS04010	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A4V09_RS04015	COG0557	exoribonuclease II activity
A4V09_RS04020	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
A4V09_RS04045	COG2205	protein histidine kinase activity
A4V09_RS04070	COG0745	RESPONSE REGULATOR receiver
A4V09_RS04075	COG5002	protein histidine kinase activity
A4V09_RS04095	COG0343	queuine tRNA-ribosyltransferase activity
A4V09_RS04110	COG1760	l-serine dehydratase
A4V09_RS04115	COG3708	Transcriptional regulator
A4V09_RS04115	COG2207	Transcriptional regulator
A4V09_RS04125	COG1476	TRANSCRIPTIONal
A4V09_RS04155	COG0129	dihydroxy-acid dehydratase activity
A4V09_RS04160	COG0028	Belongs to the TPP enzyme family
A4V09_RS04165	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
A4V09_RS04170	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A4V09_RS04180	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A4V09_RS04190	COG1160	GTP binding
A4V09_RS04195	COG0456	acetyltransferase
A4V09_RS04225	COG0516	GMP reductase activity
A4V09_RS04225	COG0517	IMP dehydrogenase activity
A4V09_RS04230	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
A4V09_RS04235	COG0668	transmembrane transport
A4V09_RS04260	COG1793	dna ligase
A4V09_RS04265	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
A4V09_RS04275	COG3842	ATPase activity
A4V09_RS04280	COG1176	ABC-type spermidine putrescine transport system, permease component I
A4V09_RS04285	COG1177	transmembrane transport
A4V09_RS04310	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A4V09_RS04315	COG3279	Response regulator of the LytR AlgR family
A4V09_RS04340	COG1136	(ABC) transporter
A4V09_RS04350	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A4V09_RS04365	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A4V09_RS04370	COG1116	anion transmembrane transporter activity
A4V09_RS04375	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A4V09_RS04380	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A4V09_RS04385	COG0165	Argininosuccinate lyase
A4V09_RS04400	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A4V09_RS04440	COG0438	transferase activity, transferring glycosyl groups
A4V09_RS04445	COG0438	transferase activity, transferring glycosyl groups
A4V09_RS04450	COG0398	Pfam SNARE associated Golgi protein
A4V09_RS04480	COG3383	formate dehydrogenase (NAD+) activity
A4V09_RS04490	COG0746	molybdenum cofactor guanylyltransferase activity
A4V09_RS04520	COG2188	Transcriptional regulator
A4V09_RS04525	COG1131	(ABC) transporter
A4V09_RS04535	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
A4V09_RS04550	COG2378	regulation of single-species biofilm formation
A4V09_RS04555	COG3340	Belongs to the peptidase S51 family
A4V09_RS04580	COG0534	Mate efflux family protein
A4V09_RS04590	COG1230	cation diffusion facilitator family transporter
A4V09_RS04600	COG2205	protein histidine kinase activity
A4V09_RS04600	COG0784	Response regulator, receiver
A4V09_RS04600	COG2198	Histidine kinase
A4V09_RS04615	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A4V09_RS04620	COG3022	response to hydroperoxide
A4V09_RS04625	COG0534	Mate efflux family protein
A4V09_RS04635	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
A4V09_RS04645	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A4V09_RS04655	COG0733	neurotransmitter:sodium symporter activity
A4V09_RS04665	COG0528	UMP kinase activity
A4V09_RS04670	COG0233	cytoplasmic translational termination
A4V09_RS04675	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A4V09_RS04680	COG4589	Belongs to the CDS family
A4V09_RS04690	COG0750	zinc metalloprotease
A4V09_RS04705	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A4V09_RS04705	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A4V09_RS04710	COG3158	transport of potassium into the cell
A4V09_RS04735	COG3279	Response regulator of the LytR AlgR family
A4V09_RS04775	COG1131	(ABC) transporter
A4V09_RS04805	COG4977	sequence-specific DNA binding
A4V09_RS04815	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
A4V09_RS04820	COG0232	Belongs to the dGTPase family. Type 2 subfamily
A4V09_RS04825	COG0358	DNA primase activity
A4V09_RS04830	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A4V09_RS04860	COG1605	Chorismate mutase
A4V09_RS04860	COG0077	Prephenate dehydratase
A4V09_RS04870	COG0540	Belongs to the ATCase OTCase family
A4V09_RS04885	COG0534	Mate efflux family protein
A4V09_RS04915	COG0725	ABC transporter, periplasmic molybdate-binding protein
A4V09_RS04920	COG4149	molybdate abc transporter
A4V09_RS04930	COG1522	sequence-specific DNA binding
A4V09_RS04935	COG0436	Aminotransferase
A4V09_RS04945	COG0527	aspartate kinase activity
A4V09_RS04955	COG0824	Thioesterase
A4V09_RS04960	COG1725	Transcriptional regulator
A4V09_RS04990	COG1607	acyl-coa hydrolase
A4V09_RS05000	COG0237	dephospho-CoA kinase activity
A4V09_RS05005	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A4V09_RS05015	COG2848	UPF0210 protein
A4V09_RS05030	COG1918	ferrous iron import across plasma membrane
A4V09_RS05030	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
A4V09_RS05050	COG0333	Belongs to the bacterial ribosomal protein bL32 family
A4V09_RS05060	COG0416	fatty acid biosynthetic process
A4V09_RS05065	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A4V09_RS05070	COG0571	ribonuclease III activity
A4V09_RS05075	COG1196	nuclear chromosome segregation
A4V09_RS05080	COG0552	protein localization to endoplasmic reticulum
A4V09_RS05085	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A4V09_RS05095	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
A4V09_RS05100	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
A4V09_RS05105	COG1606	tRNA processing
A4V09_RS05145	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A4V09_RS05155	COG1837	Belongs to the UPF0109 family
A4V09_RS05160	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A4V09_RS05165	COG0336	Belongs to the RNA methyltransferase TrmD family
A4V09_RS05180	COG0438	transferase activity, transferring glycosyl groups
A4V09_RS05195	COG0438	transferase activity, transferring glycosyl groups
A4V09_RS05205	COG0535	radical SAM domain protein
A4V09_RS05215	COG0110	maltose O-acetyltransferase activity
A4V09_RS05225	COG1216	Glycosyl transferase, family 2
A4V09_RS05280	COG4464	protein tyrosine phosphatase activity
A4V09_RS05295	COG4509	Sortase family
A4V09_RS05300	COG1316	TRANSCRIPTIONal
A4V09_RS05315	COG0789	Transcriptional regulator
A4V09_RS05315	COG4978	Transcriptional regulator
A4V09_RS05320	COG1091	dTDP-4-dehydrorhamnose reductase activity
A4V09_RS05335	COG0335	large ribosomal subunit rRNA binding
A4V09_RS05340	COG0681	Belongs to the peptidase S26 family
A4V09_RS05350	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A4V09_RS05355	COG0792	nuclease activity
A4V09_RS05360	COG1496	oxidoreductase activity
A4V09_RS05370	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A4V09_RS05380	COG1160	GTP binding
A4V09_RS05390	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A4V09_RS05395	COG1136	(ABC) transporter
A4V09_RS05395	COG0577	efflux transmembrane transporter activity
A4V09_RS05405	COG1136	(ABC) transporter
A4V09_RS05405	COG0577	efflux transmembrane transporter activity
A4V09_RS05410	COG0656	L-ascorbic acid biosynthetic process
A4V09_RS05415	COG0420	3'-5' exonuclease activity
A4V09_RS05420	COG0419	ATPase involved in DNA repair
A4V09_RS05435	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
A4V09_RS05445	COG1151	hydroxylamine reductase activity
A4V09_RS05490	COG3404	Formiminotransferase-cyclodeaminase
A4V09_RS05495	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A4V09_RS05510	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
A4V09_RS05520	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
A4V09_RS05565	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
A4V09_RS05585	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A4V09_RS05620	COG0310	cobalt ion transport
A4V09_RS05625	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
A4V09_RS05640	COG0113	porphobilinogen synthase activity
A4V09_RS05645	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
A4V09_RS05650	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A4V09_RS05655	COG0328	RNA-DNA hybrid ribonuclease activity
A4V09_RS05670	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A4V09_RS05675	COG0828	Belongs to the bacterial ribosomal protein bS21 family
A4V09_RS05680	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A4V09_RS05695	COG1686	Belongs to the peptidase S11 family
A4V09_RS05700	COG0534	Mate efflux family protein
A4V09_RS05705	COG1408	metallophosphoesterase
A4V09_RS05710	COG0714	Associated with various cellular activities
A4V09_RS05725	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
A4V09_RS05730	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
A4V09_RS05740	COG2270	Major facilitator Superfamily
A4V09_RS05745	COG1686	Belongs to the peptidase S11 family
A4V09_RS05760	COG0071	Belongs to the small heat shock protein (HSP20) family
A4V09_RS05775	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A4V09_RS05780	COG2084	Dehydrogenase
A4V09_RS05795	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A4V09_RS05800	COG1115	amino acid carrier protein
A4V09_RS05815	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A4V09_RS05840	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A4V09_RS05845	COG0134	indole-3-glycerol-phosphate synthase activity
A4V09_RS05850	COG0135	phosphoribosylanthranilate isomerase activity
A4V09_RS05860	COG0159	tryptophan synthase activity
A4V09_RS05865	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A4V09_RS05875	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
A4V09_RS05880	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
A4V09_RS05890	COG1737	Transcriptional regulator
A4V09_RS05895	COG2081	HI0933 family
A4V09_RS05905	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
A4V09_RS05910	COG0539	negative regulation of cytoplasmic translation
A4V09_RS05910	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
A4V09_RS05925	COG4656	Part of a membrane complex involved in electron transport
A4V09_RS05930	COG4658	electron transport chain
A4V09_RS05940	COG4660	Part of a membrane complex involved in electron transport
A4V09_RS05945	COG4657	Part of a membrane complex involved in electron transport
A4V09_RS05950	COG1245	4Fe-4S binding domain
A4V09_RS05950	COG2878	Part of a membrane complex involved in electron transport
A4V09_RS05970	COG0632	four-way junction helicase activity
A4V09_RS05975	COG2255	four-way junction helicase activity
A4V09_RS05985	COG0826	peptidase U32
A4V09_RS05995	COG0768	penicillin binding
A4V09_RS06000	COG1051	belongs to the nudix hydrolase family
A4V09_RS06025	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A4V09_RS06035	COG1461	Dihydroxyacetone kinase
A4V09_RS06040	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A4V09_RS06060	COG1803	Methylglyoxal synthase
A4V09_RS06065	COG0742	ribosomal rna small subunit methyltransferase
A4V09_RS06070	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
A4V09_RS06080	COG3314	Sporulation integral membrane protein YlbJ
A4V09_RS06090	COG2195	Cleaves the N-terminal amino acid of tripeptides
A4V09_RS06095	COG0739	heme binding
A4V09_RS06100	COG2357	RelA SpoT domain protein
A4V09_RS06105	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
A4V09_RS06105	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A4V09_RS06110	COG1187	pseudouridine synthase activity
A4V09_RS06115	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A4V09_RS06125	COG4221	oxidoreductase activity
A4V09_RS06135	COG0564	pseudouridine synthase activity
A4V09_RS06140	COG0681	Belongs to the peptidase S26 family
A4V09_RS06145	COG3331	DNA recombination
A4V09_RS06150	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
A4V09_RS06165	COG0745	RESPONSE REGULATOR receiver
A4V09_RS06170	COG2205	protein histidine kinase activity
A4V09_RS06175	COG1136	(ABC) transporter
A4V09_RS06180	COG0577	efflux transmembrane transporter activity
A4V09_RS06210	COG4819	ethanolamine utilization protein
A4V09_RS06215	COG4303	Ethanolamine ammonia lyase large subunit
A4V09_RS06220	COG4302	ethanolamine ammonia-lyase activity
A4V09_RS06225	COG4816	utilization protein
A4V09_RS06230	COG1012	belongs to the aldehyde dehydrogenase family
A4V09_RS06230	COG1454	alcohol dehydrogenase
A4V09_RS06245	COG4869	propanediol catabolic process
A4V09_RS06255	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
A4V09_RS06260	COG3192	ethanolamine utilization protein
A4V09_RS06270	COG0719	Fe-S assembly protein
A4V09_RS06295	COG2207	Transcriptional regulator
A4V09_RS06320	COG0534	Mate efflux family protein
A4V09_RS06325	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A4V09_RS06330	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A4V09_RS06365	COG0789	Transcriptional regulator
A4V09_RS06370	COG1131	(ABC) transporter
A4V09_RS06380	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A4V09_RS06410	COG4656	Part of a membrane complex involved in electron transport
A4V09_RS06420	COG0646	methionine synthase
A4V09_RS06420	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
A4V09_RS06440	COG1530	ribonuclease E activity
A4V09_RS06445	COG1051	belongs to the nudix hydrolase family
A4V09_RS06465	COG0211	Belongs to the bacterial ribosomal protein bL27 family
A4V09_RS06470	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A4V09_RS06475	COG1534	Rna-binding protein
A4V09_RS06480	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
A4V09_RS06485	COG1713	HD superfamily hydrolase involved in NAD metabolism
A4V09_RS06490	COG0799	negative regulation of ribosome biogenesis
A4V09_RS06495	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A4V09_RS06505	COG1609	Transcriptional regulator
A4V09_RS06520	COG0371	Dehydrogenase
A4V09_RS06540	COG1131	(ABC) transporter
A4V09_RS06575	COG1686	Belongs to the peptidase S11 family
A4V09_RS06580	COG0488	(ABC) transporter
A4V09_RS06600	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A4V09_RS06605	COG0583	DNA-binding transcription factor activity
A4V09_RS06615	COG2059	Chromate
A4V09_RS06625	COG0745	RESPONSE REGULATOR receiver
A4V09_RS06630	COG5002	protein histidine kinase activity
A4V09_RS06635	COG1136	(ABC) transporter
A4V09_RS06640	COG0577	efflux transmembrane transporter activity
A4V09_RS06655	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
A4V09_RS06670	COG2207	Transcriptional regulator
A4V09_RS06670	COG1917	Cupin 2, conserved barrel domain protein
A4V09_RS06675	COG0697	spore germination
A4V09_RS06705	COG0596	Alpha beta hydrolase
A4V09_RS06705	COG2945	thiolester hydrolase activity
A4V09_RS06710	COG0583	DNA-binding transcription factor activity
A4V09_RS06715	COG0745	RESPONSE REGULATOR receiver
A4V09_RS06720	COG5002	protein histidine kinase activity
A4V09_RS06730	COG1201	RNA secondary structure unwinding
A4V09_RS06740	COG0534	Mate efflux family protein
A4V09_RS06750	COG1136	(ABC) transporter
A4V09_RS06750	COG0577	efflux transmembrane transporter activity
A4V09_RS06765	COG0745	RESPONSE REGULATOR receiver
A4V09_RS06780	COG2801	Transposase and inactivated derivatives
A4V09_RS06790	COG1490	D-aminoacyl-tRNA deacylase activity
A4V09_RS06795	COG0628	permease
A4V09_RS06800	COG0037	tRNA processing
A4V09_RS06810	COG2801	Transposase and inactivated derivatives
A4V09_RS06820	COG0564	pseudouridine synthase activity
A4V09_RS06830	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A4V09_RS06835	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A4V09_RS06845	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A4V09_RS06855	COG2155	Conserved Protein
A4V09_RS06865	COG1686	Belongs to the peptidase S11 family
A4V09_RS06870	COG1803	Methylglyoxal synthase
A4V09_RS06880	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
A4V09_RS06885	COG2894	cell division
A4V09_RS06890	COG0768	penicillin binding
A4V09_RS06910	COG2003	Belongs to the UPF0758 family
A4V09_RS06915	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
A4V09_RS06920	COG2081	HI0933 family
A4V09_RS06925	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
A4V09_RS06930	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A4V09_RS06940	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A4V09_RS06945	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A4V09_RS06950	COG4224	UPF0291 protein
A4V09_RS06955	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A4V09_RS06980	COG1702	phosphate starvation-inducible protein PhoH
A4V09_RS06985	COG2176	DNA-directed DNA polymerase activity
A4V09_RS07005	COG0596	Alpha beta hydrolase
A4V09_RS07010	COG3453	Protein conserved in bacteria
A4V09_RS07010	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A4V09_RS07020	COG1136	(ABC) transporter
A4V09_RS07045	COG0745	RESPONSE REGULATOR receiver
A4V09_RS07055	COG1136	(ABC) transporter
A4V09_RS07060	COG5293	efflux transmembrane transporter activity
A4V09_RS07070	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
A4V09_RS07095	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A4V09_RS07095	COG1199	ATP-dependent helicase activity
A4V09_RS07115	COG0642	Histidine kinase
A4V09_RS07115	COG5002	protein histidine kinase activity
A4V09_RS07120	COG0745	RESPONSE REGULATOR receiver
A4V09_RS07125	COG0688	phosphatidylethanolamine metabolic process
A4V09_RS07130	COG1183	phosphatidylcholine synthase activity
A4V09_RS07145	COG1696	Membrane protein involved in D-alanine export
A4V09_RS07160	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A4V09_RS07180	COG0454	-acetyltransferase
A4V09_RS07200	COG3344	reverse transcriptase
A4V09_RS07280	COG3344	reverse transcriptase
A4V09_RS07340	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A4V09_RS07345	COG4509	Sortase family
A4V09_RS07365	COG0270	DNA (cytosine-5-)-methyltransferase activity
A4V09_RS07410	COG1136	(ABC) transporter
A4V09_RS07415	COG5002	protein histidine kinase activity
A4V09_RS07420	COG0745	RESPONSE REGULATOR receiver
A4V09_RS07445	COG3250	beta-galactosidase activity
A4V09_RS07450	COG2211	Major facilitator Superfamily
A4V09_RS07475	COG3706	GGDEF domain
A4V09_RS07495	COG2205	protein histidine kinase activity
A4V09_RS07510	COG0583	DNA-binding transcription factor activity
A4V09_RS07520	COG1482	cell wall glycoprotein biosynthetic process
A4V09_RS07525	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A4V09_RS07540	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
A4V09_RS07545	COG2942	2-epimerase
A4V09_RS07550	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
A4V09_RS07555	COG0395	ABC-type sugar transport system, permease component
A4V09_RS07560	COG1175	transmembrane transport
A4V09_RS07565	COG2182	Extracellular solute-binding protein
A4V09_RS07570	COG1609	Transcriptional regulator
A4V09_RS07620	COG2176	DNA-directed DNA polymerase activity
A4V09_RS07670	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A4V09_RS07690	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
A4V09_RS07715	COG1674	ftsk spoiiie
A4V09_RS07720	COG1968	undecaprenyl-diphosphatase activity
A4V09_RS07725	COG0740	serine-type endopeptidase activity
A4V09_RS07730	COG0217	transcriptional regulatory protein
A4V09_RS07735	COG1253	flavin adenine dinucleotide binding
A4V09_RS07740	COG3344	reverse transcriptase
A4V09_RS07750	COG2337	Toxic component of a toxin-antitoxin (TA) module
A4V09_RS07755	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A4V09_RS07760	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
A4V09_RS07760	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A4V09_RS07765	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
A4V09_RS07770	COG0488	(ABC) transporter
A4V09_RS07780	COG1131	(ABC) transporter
A4V09_RS07795	COG1802	Transcriptional regulator
A4V09_RS07800	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A4V09_RS07805	COG1404	Belongs to the peptidase S8 family
A4V09_RS07830	COG1546	Belongs to the CinA family
A4V09_RS07830	COG1058	Belongs to the CinA family
A4V09_RS07835	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A4V09_RS07840	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A4V09_RS07845	COG1758	RNA polymerase activity
A4V09_RS07850	COG0194	GDP metabolic process
A4V09_RS07855	COG2052	Domain of unknown function (DUF370)
A4V09_RS07860	COG1561	YicC-like family, N-terminal region
A4V09_RS07865	COG1293	RNA-binding protein homologous to eukaryotic snRNP
A4V09_RS07880	COG2198	Histidine kinase
A4V09_RS07880	COG0643	Histidine kinase
A4V09_RS07890	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
A4V09_RS07895	COG1776	CheC inhibitor of MCP methylation
A4V09_RS07905	COG2201	protein-glutamate methylesterase activity
A4V09_RS07925	COG0495	leucyl-tRNA aminoacylation
A4V09_RS07935	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A4V09_RS07940	COG0287	Prephenate dehydrogenase
A4V09_RS07955	COG4716	Myosin-crossreactive antigen
A4V09_RS07960	COG2986	histidine ammonia-lyase
A4V09_RS07975	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A4V09_RS07990	COG0784	Response regulator, receiver
A4V09_RS07990	COG2205	protein histidine kinase activity
A4V09_RS08005	COG5001	Diguanylate cyclase
A4V09_RS08005	COG3300	MHYT domain
A4V09_RS08030	COG1773	rubredoxin
A4V09_RS08030	COG0426	domain, Protein
A4V09_RS08105	COG3290	protein histidine kinase activity
A4V09_RS08195	COG1131	(ABC) transporter
A4V09_RS08205	COG0681	Belongs to the peptidase S26 family
A4V09_RS08270	COG0175	sulfate reduction
A4V09_RS08285	COG2801	Transposase and inactivated derivatives
A4V09_RS08310	COG2003	Belongs to the UPF0758 family
A4V09_RS08330	COG0784	Response regulator, receiver
A4V09_RS08330	COG2205	protein histidine kinase activity
A4V09_RS08335	COG2205	protein histidine kinase activity
A4V09_RS08345	COG2188	Transcriptional regulator
A4V09_RS08350	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
A4V09_RS08355	COG0406	alpha-ribazole phosphatase activity
A4V09_RS08360	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A4V09_RS08360	COG0072	phenylalanine-tRNA ligase activity
A4V09_RS08365	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
A4V09_RS08375	COG2247	cell wall binding repeat
A4V09_RS08375	COG2385	sporulation resulting in formation of a cellular spore
A4V09_RS08405	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
A4V09_RS08415	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A4V09_RS08445	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
A4V09_RS08480	COG0066	3-isopropylmalate dehydratase activity
A4V09_RS08485	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A4V09_RS08490	COG0583	DNA-binding transcription factor activity
A4V09_RS08495	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
A4V09_RS08500	COG0440	acetolactate synthase activity
A4V09_RS08530	COG0747	negative chemotaxis
A4V09_RS08535	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A4V09_RS08540	COG0601	transmembrane transport
A4V09_RS08550	COG0583	DNA-binding transcription factor activity
A4V09_RS08560	COG3620	sequence-specific DNA binding
A4V09_RS08570	COG1131	(ABC) transporter
A4V09_RS08625	COG1475	DNA binding
A4V09_RS08630	COG3969	phosphoadenosine phosphosulfate
A4V09_RS08645	COG0546	phosphoglycolate phosphatase activity
A4V09_RS08660	COG3842	ATPase activity
A4V09_RS08665	COG0395	ABC-type sugar transport system, permease component
A4V09_RS08670	COG4209	transmembrane transport
A4V09_RS08720	COG5002	protein histidine kinase activity
A4V09_RS08725	COG0745	RESPONSE REGULATOR receiver
A4V09_RS08740	COG1131	(ABC) transporter
A4V09_RS08750	COG5504	Zn-dependent protease
A4V09_RS08755	COG0789	Transcriptional regulator
A4V09_RS08760	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A4V09_RS08775	COG3250	beta-galactosidase activity
A4V09_RS08780	COG0355	proton-transporting ATP synthase activity, rotational mechanism
A4V09_RS08785	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
A4V09_RS08790	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A4V09_RS08795	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
A4V09_RS08800	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A4V09_RS08815	COG0356	it plays a direct role in the translocation of protons across the membrane
A4V09_RS08830	COG3118	belongs to the thioredoxin family
A4V09_RS08835	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A4V09_RS08840	COG2211	Major facilitator Superfamily
A4V09_RS08845	COG2272	Belongs to the type-B carboxylesterase lipase family
A4V09_RS08855	COG4977	sequence-specific DNA binding
A4V09_RS08855	COG1917	Cupin 2, conserved barrel domain protein
A4V09_RS08860	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A4V09_RS08895	COG0745	RESPONSE REGULATOR receiver
A4V09_RS08910	COG1131	(ABC) transporter
A4V09_RS08915	COG5002	protein histidine kinase activity
A4V09_RS08915	COG3850	Histidine kinase
A4V09_RS08950	COG4555	ABC transporter
A4V09_RS09010	COG0583	DNA-binding transcription factor activity
A4V09_RS09015	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A4V09_RS09020	COG1278	Cold shock
A4V09_RS09035	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A4V09_RS09040	COG1882	Formate acetyltransferase
A4V09_RS09045	COG0351	phosphomethylpyrimidine kinase
A4V09_RS09045	COG0352	thiamine-phosphate diphosphorylase activity
A4V09_RS09050	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A4V09_RS09070	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A4V09_RS09075	COG1393	Belongs to the ArsC family
A4V09_RS09085	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A4V09_RS09090	COG2508	Transcriptional regulator
A4V09_RS09110	COG2162	N-hydroxyarylamine O-acetyltransferase activity
A4V09_RS09125	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A4V09_RS09140	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A4V09_RS09165	COG1132	(ABC) transporter
A4V09_RS09170	COG1132	(ABC) transporter
A4V09_RS09180	COG0583	DNA-binding transcription factor activity
A4V09_RS09190	COG0564	pseudouridine synthase activity
A4V09_RS09200	COG5001	Diguanylate cyclase
A4V09_RS09230	COG2819	hydrolase of the alpha beta superfamily
A4V09_RS09245	COG3588	fructose-bisphosphate aldolase
A4V09_RS09250	COG1027	Aspartate ammonia-lyase
A4V09_RS09255	COG0583	DNA-binding transcription factor activity
A4V09_RS09290	COG2207	Transcriptional regulator
A4V09_RS09305	COG1131	(ABC) transporter
A4V09_RS09350	COG0534	Mate efflux family protein
A4V09_RS09380	COG0789	Transcriptional regulator
A4V09_RS09390	COG1595	DNA-templated transcription, initiation
A4V09_RS09450	COG1278	Cold shock
A4V09_RS09455	COG5290	Psort location Cytoplasmic, score
A4V09_RS09460	COG3507	Belongs to the glycosyl hydrolase 43 family
A4V09_RS09490	COG1032	radical SAM domain protein
A4V09_RS09510	COG2274	protein secretion by the type I secretion system
A4V09_RS09515	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A4V09_RS09535	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A4V09_RS09545	COG1131	(ABC) transporter
A4V09_RS09580	COG4129	membrane
A4V09_RS09610	COG1733	regulation of RNA biosynthetic process
A4V09_RS09625	COG4974	Belongs to the 'phage' integrase family
A4V09_RS09635	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
A4V09_RS09660	COG1733	regulation of RNA biosynthetic process
A4V09_RS09680	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
A4V09_RS09685	COG0052	Belongs to the universal ribosomal protein uS2 family
A4V09_RS09705	COG0515	serine threonine protein kinase
A4V09_RS09715	COG1307	EDD domain protein, DegV family
A4V09_RS09725	COG0577	efflux transmembrane transporter activity
A4V09_RS09740	COG0745	RESPONSE REGULATOR receiver
A4V09_RS09745	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A4V09_RS09750	COG0395	ABC-type sugar transport system, permease component
A4V09_RS09755	COG1175	transmembrane transport
A4V09_RS09780	COG1609	Transcriptional regulator
A4V09_RS09795	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
A4V09_RS09800	COG0124	histidyl-tRNA synthetase
A4V09_RS09810	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A4V09_RS09815	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A4V09_RS09820	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A4V09_RS09835	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
A4V09_RS09835	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A4V09_RS09840	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A4V09_RS09840	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A4V09_RS09865	COG4536	flavin adenine dinucleotide binding
A4V09_RS09880	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
A4V09_RS09885	COG3250	beta-galactosidase activity
A4V09_RS09890	COG2388	GCN5-related N-acetyl-transferase
A4V09_RS09895	COG0534	Mate efflux family protein
A4V09_RS09915	COG2816	NAD+ diphosphatase activity
A4V09_RS09920	COG1136	(ABC) transporter
A4V09_RS09950	COG4106	trans-aconitate 2-methyltransferase activity
A4V09_RS09955	COG1012	belongs to the aldehyde dehydrogenase family
A4V09_RS09965	COG0561	phosphatase activity
A4V09_RS09970	COG0546	phosphoglycolate phosphatase activity
A4V09_RS09980	COG0561	phosphatase activity
A4V09_RS09990	COG1116	anion transmembrane transporter activity
A4V09_RS09995	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A4V09_RS10000	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A4V09_RS10010	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A4V09_RS10015	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A4V09_RS10020	COG0493	'glutamate synthase
A4V09_RS10020	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
A4V09_RS10025	COG0402	S-adenosylhomocysteine deaminase activity
A4V09_RS10035	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A4V09_RS10045	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
A4V09_RS10050	COG0534	Mate efflux family protein
A4V09_RS10060	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A4V09_RS10070	COG0295	cytidine deaminase activity
A4V09_RS10075	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
A4V09_RS10085	COG3250	beta-galactosidase activity
A4V09_RS10090	COG0395	ABC-type sugar transport system, permease component
A4V09_RS10095	COG1175	transmembrane transport
A4V09_RS10100	COG1653	transport
A4V09_RS10110	COG1115	amino acid carrier protein
A4V09_RS10120	COG0205	6-phosphofructokinase activity
A4V09_RS10130	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A4V09_RS10135	COG4608	Belongs to the ABC transporter superfamily
A4V09_RS10140	COG0444	Belongs to the ABC transporter superfamily
A4V09_RS10145	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A4V09_RS10150	COG0601	transmembrane transport
A4V09_RS10155	COG0747	negative chemotaxis
A4V09_RS10180	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A4V09_RS10185	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A4V09_RS10190	COG1733	regulation of RNA biosynthetic process
A4V09_RS10200	COG0488	(ABC) transporter
A4V09_RS10205	COG1735	metal-dependent hydrolase with the TIM-barrel fold
A4V09_RS10210	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A4V09_RS10215	COG0460	homoserine dehydrogenase
A4V09_RS10290	COG3052	prosthetic group binding
A4V09_RS10295	COG3404	Formiminotransferase-cyclodeaminase
A4V09_RS10305	COG1228	amidohydrolase
A4V09_RS10320	COG0492	ferredoxin-NADP+ reductase activity
A4V09_RS10330	COG2378	regulation of single-species biofilm formation
A4V09_RS10335	COG0693	protein deglycase activity
A4V09_RS10355	COG2207	Transcriptional regulator
A4V09_RS10355	COG3708	Transcriptional regulator
A4V09_RS10360	COG2986	histidine ammonia-lyase
A4V09_RS10365	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
A4V09_RS10395	COG2986	histidine ammonia-lyase
A4V09_RS10415	COG5598	trimethylamine methyltransferase
A4V09_RS10420	COG0251	oxidation-reduction process
A4V09_RS10435	COG1115	amino acid carrier protein
A4V09_RS10450	COG0488	(ABC) transporter
A4V09_RS10455	COG1131	(ABC) transporter
A4V09_RS10470	COG0745	RESPONSE REGULATOR receiver
A4V09_RS10475	COG2205	protein histidine kinase activity
A4V09_RS10485	COG1175	transmembrane transport
A4V09_RS10490	COG1653	transport
A4V09_RS10495	COG2207	Transcriptional regulator
A4V09_RS10500	COG0242	peptide deformylase activity
A4V09_RS10530	COG2986	histidine ammonia-lyase
A4V09_RS10555	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
A4V09_RS10555	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
A4V09_RS10570	COG1247	-acetyltransferase
A4V09_RS10590	COG0577	efflux transmembrane transporter activity
A4V09_RS10615	COG1757	Na H antiporter
A4V09_RS10625	COG0251	oxidation-reduction process
A4V09_RS10630	COG2964	Protein conserved in bacteria
A4V09_RS10650	COG4399	Belongs to the UPF0754 family
A4V09_RS10655	COG3681	Belongs to the UPF0597 family
A4V09_RS10665	COG0484	heat shock protein binding
A4V09_RS10675	COG2357	RelA SpoT domain protein
A4V09_RS10685	COG0534	Mate efflux family protein
A4V09_RS10695	COG1803	Methylglyoxal synthase
A4V09_RS10700	COG1597	lipid kinase activity
A4V09_RS10705	COG0584	glycerophosphoryl diester phosphodiesterase
A4V09_RS10720	COG0745	RESPONSE REGULATOR receiver
A4V09_RS10725	COG0534	Mate efflux family protein
A4V09_RS10730	COG1979	alcohol dehydrogenase
A4V09_RS10775	COG0583	DNA-binding transcription factor activity
A4V09_RS10780	COG1216	Glycosyl transferase, family 2
A4V09_RS10785	COG1194	a g-specific adenine glycosylase
A4V09_RS10795	COG0647	UMP catabolic process
A4V09_RS10815	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
A4V09_RS10865	COG1473	amidohydrolase
A4V09_RS10870	COG1288	antiporter activity
A4V09_RS10890	COG0741	lytic transglycosylase activity
A4V09_RS10890	COG1196	nuclear chromosome segregation
A4V09_RS10890	COG0739	heme binding
A4V09_RS10920	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
A4V09_RS10930	COG0542	response to heat
A4V09_RS10940	COG0151	Belongs to the GarS family
A4V09_RS10945	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A4V09_RS10950	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
A4V09_RS10955	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A4V09_RS10980	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
A4V09_RS10985	COG0167	dihydroorotate dehydrogenase activity
A4V09_RS10995	COG0284	orotidine-5'-phosphate decarboxylase activity
A4V09_RS11000	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A4V09_RS11005	COG1278	Cold shock
A4V09_RS11010	COG3706	GGDEF domain
A4V09_RS11040	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
A4V09_RS11050	COG1122	ATPase activity
A4V09_RS11055	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A4V09_RS11060	COG0218	Necessary for normal cell division and for the maintenance of normal septation
A4V09_RS11065	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A4V09_RS11080	COG0544	peptidyl-prolyl cis-trans isomerase activity
A4V09_RS11100	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A4V09_RS11130	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A4V09_RS11150	COG1940	carbohydrate kinase activity
A4V09_RS11155	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
A4V09_RS11165	COG0674	pyruvate-flavodoxin oxidoreductase activity
A4V09_RS11185	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A4V09_RS11190	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A4V09_RS11200	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A4V09_RS11215	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A4V09_RS11230	COG1309	transcriptional regulator
A4V09_RS11250	COG3279	Response regulator of the LytR AlgR family
A4V09_RS11315	COG1309	transcriptional regulator
A4V09_RS11330	COG1136	(ABC) transporter
A4V09_RS11335	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A4V09_RS11340	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A4V09_RS11380	COG5426	von Willebrand factor, type A
A4V09_RS11385	COG1757	Na H antiporter
A4V09_RS11420	COG1959	2 iron, 2 sulfur cluster binding
A4V09_RS11455	COG0745	RESPONSE REGULATOR receiver
A4V09_RS11480	COG2233	PERMEase
A4V09_RS11485	COG1904	glucuronate isomerase
A4V09_RS11505	COG1609	Transcriptional regulator
A4V09_RS11510	COG2721	sulfolactate sulfo-lyase activity
A4V09_RS11525	COG4894	glucomannan catabolic process
A4V09_RS11530	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A4V09_RS11545	COG1523	belongs to the glycosyl hydrolase 13 family
A4V09_RS11585	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A4V09_RS11590	COG1309	transcriptional regulator
A4V09_RS11600	COG0756	dUTP diphosphatase activity
A4V09_RS11605	COG0602	queuosine metabolic process
A4V09_RS11610	COG1185	polyribonucleotide nucleotidyltransferase activity
A4V09_RS11615	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
A4V09_RS11620	COG0791	NLP P60 protein
A4V09_RS11625	COG0704	Plays a role in the regulation of phosphate uptake
A4V09_RS11630	COG0196	riboflavin kinase activity
A4V09_RS11635	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A4V09_RS11640	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
A4V09_RS11645	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
A4V09_RS11650	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A4V09_RS11660	COG2740	Nucleic-acid-binding protein implicated in transcription termination
A4V09_RS11665	COG0195	Participates in both transcription termination and antitermination
A4V09_RS11680	COG0598	Magnesium transport protein CorA
A4V09_RS11685	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A4V09_RS11690	COG0187	DNA topoisomerase II activity
A4V09_RS11695	COG0561	phosphatase activity
A4V09_RS11700	COG0671	phosphoesterase, PA-phosphatase related
A4V09_RS11705	COG0303	'Molybdopterin
A4V09_RS11710	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
A4V09_RS11715	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A4V09_RS11720	COG2414	aldehyde ferredoxin oxidoreductase
A4V09_RS11730	COG0281	malic enzyme
A4V09_RS11735	COG1027	Aspartate ammonia-lyase
A4V09_RS11745	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
A4V09_RS11750	COG1027	Aspartate ammonia-lyase
A4V09_RS11765	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A4V09_RS11770	COG0446	pyridine nucleotide-disulphide oxidoreductase
A4V09_RS11770	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A4V09_RS11805	COG5598	trimethylamine methyltransferase
A4V09_RS11820	COG3273	potassium ion transport
A4V09_RS11820	COG0471	metal ion transport
A4V09_RS11835	COG2508	Transcriptional regulator
A4V09_RS11860	COG0534	Mate efflux family protein
A4V09_RS11865	COG0613	PHP domain protein
A4V09_RS11885	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
A4V09_RS11895	COG2207	Transcriptional regulator
A4V09_RS11895	COG4753	response regulator
A4V09_RS11900	COG0395	ABC-type sugar transport system, permease component
A4V09_RS11905	COG1175	transmembrane transport
A4V09_RS11915	COG2972	Histidine kinase
A4V09_RS11920	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A4V09_RS11930	COG4667	esterase of the alpha-beta hydrolase superfamily
A4V09_RS11980	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A4V09_RS11990	COG0395	ABC-type sugar transport system, permease component
A4V09_RS11995	COG1175	transmembrane transport
A4V09_RS12005	COG3681	Belongs to the UPF0597 family
A4V09_RS12010	COG1979	alcohol dehydrogenase
A4V09_RS12015	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A4V09_RS12030	COG2084	Dehydrogenase
A4V09_RS12060	COG0038	chloride channel
A4V09_RS12065	COG1757	Na H antiporter
A4V09_RS12070	COG1012	belongs to the aldehyde dehydrogenase family
A4V09_RS12075	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
A4V09_RS12080	COG0784	Response regulator, receiver
A4V09_RS12080	COG2205	protein histidine kinase activity
A4V09_RS12080	COG2198	Histidine kinase
A4V09_RS12085	COG0840	transmembrane signaling receptor activity
A4V09_RS12135	COG1881	PFAM PEBP family protein
A4V09_RS12145	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A4V09_RS12150	COG1131	(ABC) transporter
A4V09_RS12165	COG2205	protein histidine kinase activity
A4V09_RS12230	COG3119	arylsulfatase activity
A4V09_RS12235	COG0395	ABC-type sugar transport system, permease component
A4V09_RS12240	COG1175	transmembrane transport
A4V09_RS12250	COG3279	Response regulator of the LytR AlgR family
A4V09_RS12255	COG2972	Histidine kinase
A4V09_RS12260	COG0641	radical SAM
A4V09_RS12290	COG0395	ABC-type sugar transport system, permease component
A4V09_RS12295	COG1175	transmembrane transport
A4V09_RS12305	COG2972	Histidine kinase
A4V09_RS12310	COG4753	response regulator
A4V09_RS12310	COG2207	Transcriptional regulator
A4V09_RS12335	COG3842	ATPase activity
A4V09_RS12340	COG1176	ABC-type spermidine putrescine transport system, permease component I
A4V09_RS12345	COG1177	transmembrane transport
A4V09_RS12350	COG0564	pseudouridine synthase activity
A4V09_RS12385	COG2205	protein histidine kinase activity
A4V09_RS12390	COG2205	protein histidine kinase activity
A4V09_RS12390	COG0745	RESPONSE REGULATOR receiver
A4V09_RS12390	COG4191	Histidine kinase
A4V09_RS12395	COG1854	S-ribosylhomocysteine lyase activity
A4V09_RS12400	COG5002	protein histidine kinase activity
A4V09_RS12400	COG5001	Diguanylate cyclase
A4V09_RS12410	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
A4V09_RS12415	COG3608	succinylglutamate desuccinylase aspartoacylase
A4V09_RS12415	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
A4V09_RS12420	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A4V09_RS12420	COG0425	Belongs to the sulfur carrier protein TusA family
A4V09_RS12450	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A4V09_RS12455	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A4V09_RS12460	COG0549	Belongs to the carbamate kinase family
A4V09_RS12465	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A4V09_RS12470	COG0287	Prephenate dehydrogenase
A4V09_RS12475	COG3958	Transketolase
A4V09_RS12480	COG3959	Transketolase, thiamine diphosphate binding domain
A4V09_RS12485	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
A4V09_RS12485	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
A4V09_RS12490	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
A4V09_RS12495	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A4V09_RS12500	COG2186	Transcriptional regulator
A4V09_RS12515	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A4V09_RS12520	COG1253	flavin adenine dinucleotide binding
A4V09_RS12530	COG0395	ABC-type sugar transport system, permease component
A4V09_RS12535	COG4209	transmembrane transport
A4V09_RS12545	COG2207	Transcriptional regulator
A4V09_RS12545	COG4753	response regulator
A4V09_RS12550	COG2972	Histidine kinase
A4V09_RS12560	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A4V09_RS12570	COG0215	cysteine-tRNA ligase activity
A4V09_RS12575	COG1045	serine acetyltransferase
A4V09_RS12580	COG5001	Diguanylate cyclase
A4V09_RS12595	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A4V09_RS12600	COG0488	(ABC) transporter
A4V09_RS12605	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
A4V09_RS12615	COG1937	Protein conserved in bacteria
A4V09_RS12640	COG3708	Transcriptional regulator
A4V09_RS12640	COG2207	Transcriptional regulator
A4V09_RS12665	COG1069	ribulokinase activity
A4V09_RS12670	COG1609	Transcriptional regulator
A4V09_RS12720	COG1120	ATPase activity
A4V09_RS12725	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4V09_RS12730	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4V09_RS12810	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
A4V09_RS12810	COG0674	pyruvate-flavodoxin oxidoreductase activity
A4V09_RS12815	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A4V09_RS12825	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A4V09_RS12830	COG1414	Transcriptional regulator
A4V09_RS12840	COG1937	Protein conserved in bacteria
A4V09_RS12855	COG0577	efflux transmembrane transporter activity
A4V09_RS12855	COG1136	(ABC) transporter
A4V09_RS12865	COG0601	transmembrane transport
A4V09_RS12900	COG4753	response regulator
A4V09_RS12900	COG2207	Transcriptional regulator
A4V09_RS12905	COG2972	Histidine kinase
A4V09_RS12910	COG1653	transport
A4V09_RS12915	COG1473	amidohydrolase
A4V09_RS12925	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A4V09_RS12935	COG0583	DNA-binding transcription factor activity
A4V09_RS12940	COG4608	Belongs to the ABC transporter superfamily
A4V09_RS12955	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A4V09_RS12960	COG0601	transmembrane transport
A4V09_RS12965	COG2226	methyltransferase
A4V09_RS12970	COG2226	methyltransferase
A4V09_RS12975	COG0251	oxidation-reduction process
A4V09_RS12980	COG1199	ATP-dependent helicase activity
A4V09_RS12980	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A4V09_RS12995	COG1937	Protein conserved in bacteria
A4V09_RS13005	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A4V09_RS13025	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A4V09_RS13030	COG1408	metallophosphoesterase
A4V09_RS13035	COG1104	cysteine desulfurase activity
A4V09_RS13045	COG0708	Exodeoxyribonuclease III
A4V09_RS13055	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
A4V09_RS13075	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A4V09_RS13085	COG0733	neurotransmitter:sodium symporter activity
A4V09_RS13095	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A4V09_RS13105	COG1063	alcohol dehydrogenase
A4V09_RS13110	COG0138	bifunctional purine biosynthesis protein purh
A4V09_RS13120	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A4V09_RS13145	COG0519	Catalyzes the synthesis of GMP from XMP
A4V09_RS13165	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A4V09_RS13165	COG0723	plastoquinol--plastocyanin reductase activity
A4V09_RS13180	COG1592	Rubrerythrin
A4V09_RS13185	COG2315	Protein conserved in bacteria
A4V09_RS13190	COG0028	Belongs to the TPP enzyme family
A4V09_RS13195	COG0440	acetolactate synthase activity
A4V09_RS13235	COG2207	Transcriptional regulator
A4V09_RS13235	COG3708	Transcriptional regulator
A4V09_RS13255	COG3344	reverse transcriptase
A4V09_RS13270	COG0745	RESPONSE REGULATOR receiver
A4V09_RS13285	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A4V09_RS13295	COG0037	tRNA processing
A4V09_RS13320	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
A4V09_RS13330	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A4V09_RS13340	COG0617	tRNA 3'-terminal CCA addition
A4V09_RS13345	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A4V09_RS13360	COG0698	ribose 5-phosphate isomerase
A4V09_RS13365	COG0009	L-threonylcarbamoyladenylate synthase
A4V09_RS13370	COG0860	N-Acetylmuramoyl-L-alanine amidase
A4V09_RS13395	COG4862	establishment of competence for transformation
A4V09_RS13410	COG2221	Nitrite and sulphite reductase 4Fe-4S
A4V09_RS13420	COG1028	Short-chain dehydrogenase reductase Sdr
A4V09_RS13435	COG3344	reverse transcriptase
A4V09_RS13440	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A4V09_RS13445	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A4V09_RS13450	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
A4V09_RS13455	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
A4V09_RS13470	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A4V09_RS13470	COG1328	CTP reductase activity
A4V09_RS13475	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A4V09_RS13505	COG0582	viral genome integration into host DNA
A4V09_RS13515	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A4V09_RS13525	COG0191	fructose-bisphosphate aldolase activity
A4V09_RS13535	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A4V09_RS13540	COG2890	protein-(glutamine-N5) methyltransferase activity
A4V09_RS13545	COG3872	metal-dependent enzyme
A4V09_RS13550	COG0254	rRNA binding
A4V09_RS13565	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A4V09_RS13570	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A4V09_RS13575	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A4V09_RS13585	COG1316	TRANSCRIPTIONal
A4V09_RS13595	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A4V09_RS13600	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A4V09_RS13610	COG3901	Regulator of nitric oxide reductase transcription
A4V09_RS13610	COG0348	domain, Protein
A4V09_RS13625	COG1063	alcohol dehydrogenase
A4V09_RS13630	COG1940	carbohydrate kinase activity
A4V09_RS13635	COG3706	GGDEF domain
A4V09_RS13650	COG0784	Response regulator, receiver
A4V09_RS13650	COG2205	protein histidine kinase activity
A4V09_RS13670	COG1028	Short-chain dehydrogenase reductase Sdr
A4V09_RS13710	COG0789	Transcriptional regulator
A4V09_RS13710	COG4978	Transcriptional regulator
A4V09_RS13715	COG1720	tRNA m6t6A37 methyltransferase activity
A4V09_RS13720	COG4154	Belongs to the RbsD FucU family
A4V09_RS13725	COG0235	Class ii aldolase
A4V09_RS13730	COG1070	Carbohydrate kinase
A4V09_RS13735	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
A4V09_RS13740	COG2207	Transcriptional regulator
A4V09_RS13740	COG1917	Cupin 2, conserved barrel domain protein
A4V09_RS13745	COG1022	Amp-dependent synthetase and ligase
A4V09_RS13750	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A4V09_RS13770	COG1309	transcriptional regulator
A4V09_RS13780	COG0789	Transcriptional regulator
A4V09_RS13785	COG2211	Major facilitator Superfamily
A4V09_RS13790	COG3622	Belongs to the hyi family
A4V09_RS13795	COG0673	inositol 2-dehydrogenase activity
A4V09_RS13810	COG4409	exo-alpha-(2->6)-sialidase activity
A4V09_RS13815	COG0673	inositol 2-dehydrogenase activity
A4V09_RS13830	COG1653	transport
A4V09_RS13835	COG0662	Cupin 2, conserved barrel domain protein
A4V09_RS13835	COG2207	Transcriptional regulator
A4V09_RS13890	COG1757	Na H antiporter
A4V09_RS13895	COG1929	Belongs to the glycerate kinase type-1 family
A4V09_RS13900	COG3835	regulator
A4V09_RS13925	COG2721	sulfolactate sulfo-lyase activity
A4V09_RS13930	COG0246	Mannitol dehydrogenase
A4V09_RS13940	COG1063	alcohol dehydrogenase
A4V09_RS13955	COG0534	Mate efflux family protein
A4V09_RS13960	COG0110	maltose O-acetyltransferase activity
A4V09_RS13965	COG2207	Transcriptional regulator
A4V09_RS13965	COG1917	Cupin 2, conserved barrel domain protein
A4V09_RS13980	COG0513	Belongs to the DEAD box helicase family
A4V09_RS13995	COG0534	Mate efflux family protein
A4V09_RS14055	COG0519	Catalyzes the synthesis of GMP from XMP
A4V09_RS14060	COG1309	transcriptional regulator
A4V09_RS14090	COG4191	Histidine kinase
A4V09_RS14195	COG0740	serine-type endopeptidase activity
A4V09_RS14200	COG4695	Portal protein
A4V09_RS14250	COG4133	protoheme IX ABC transporter activity
A4V09_RS14255	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A4V09_RS14255	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A4V09_RS14335	COG1395	domain, Protein
A4V09_RS14365	COG4496	protein, YerC YecD
A4V09_RS14370	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
A4V09_RS14395	COG1242	4 iron, 4 sulfur cluster binding
A4V09_RS14405	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A4V09_RS14410	COG0726	polysaccharide deacetylase
A4V09_RS14420	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
A4V09_RS14420	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
A4V09_RS14445	COG0733	neurotransmitter:sodium symporter activity
A4V09_RS14455	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A4V09_RS14470	COG0653	protein targeting
A4V09_RS14510	COG3507	Belongs to the glycosyl hydrolase 43 family
A4V09_RS14515	COG0395	ABC-type sugar transport system, permease component
A4V09_RS14520	COG1175	transmembrane transport
A4V09_RS14525	COG1653	transport
A4V09_RS14530	COG1609	Transcriptional regulator
A4V09_RS14535	COG4753	response regulator
A4V09_RS14535	COG2207	Transcriptional regulator
A4V09_RS14540	COG3250	beta-galactosidase activity
A4V09_RS14555	COG0395	ABC-type sugar transport system, permease component
A4V09_RS14560	COG1175	transmembrane transport
A4V09_RS14565	COG1653	transport
A4V09_RS14570	COG2972	Histidine kinase
A4V09_RS14575	COG4753	response regulator
A4V09_RS14575	COG2207	Transcriptional regulator
A4V09_RS14595	COG0191	fructose-bisphosphate aldolase activity
A4V09_RS14620	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A4V09_RS14650	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A4V09_RS14655	COG2986	histidine ammonia-lyase
A4V09_RS14660	COG0583	DNA-binding transcription factor activity
A4V09_RS14675	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
A4V09_RS14685	COG1595	DNA-templated transcription, initiation
A4V09_RS14695	COG0165	Argininosuccinate lyase
A4V09_RS14700	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
A4V09_RS14725	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A4V09_RS14725	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
A4V09_RS14730	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A4V09_RS14735	COG1418	mRNA catabolic process
A4V09_RS14740	COG0302	gtp cyclohydrolase
A4V09_RS14745	COG0285	dihydrofolate synthase activity
A4V09_RS14755	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
A4V09_RS14760	COG3853	Toxic anion resistance protein (TelA)
A4V09_RS14770	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A4V09_RS14785	COG0733	neurotransmitter:sodium symporter activity
A4V09_RS14800	COG1079	Belongs to the binding-protein-dependent transport system permease family
A4V09_RS14805	COG4603	Belongs to the binding-protein-dependent transport system permease family
A4V09_RS14810	COG3845	ABC transporter
A4V09_RS14815	COG1744	ABC transporter substrate-binding protein PnrA-like
A4V09_RS14835	COG1811	Na channel or pump
A4V09_RS14840	COG3870	Protein conserved in bacteria
A4V09_RS14860	COG1396	sequence-specific DNA binding
A4V09_RS14880	COG1725	Transcriptional regulator
A4V09_RS14885	COG1131	(ABC) transporter
A4V09_RS14895	COG1501	Belongs to the glycosyl hydrolase 31 family
A4V09_RS14915	COG0395	ABC-type sugar transport system, permease component
A4V09_RS14930	COG4753	response regulator
A4V09_RS14930	COG2207	Transcriptional regulator
A4V09_RS14945	COG0517	IMP dehydrogenase activity
A4V09_RS14945	COG0516	GMP reductase activity
A4V09_RS14955	COG0459	protein refolding
A4V09_RS14960	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A4V09_RS14970	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A4V09_RS14975	COG0758	DNA mediated transformation
A4V09_RS14985	COG2207	Transcriptional regulator
A4V09_RS15000	COG0826	peptidase U32
A4V09_RS15020	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
A4V09_RS15035	COG4472	Bacterial protein of unknown function (DUF965)
A4V09_RS15040	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A4V09_RS15050	COG0301	tRNA thio-modification
A4V09_RS15055	COG1104	cysteine desulfurase activity
A4V09_RS15060	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A4V09_RS15065	COG2264	protein methyltransferase activity
A4V09_RS15095	COG1132	(ABC) transporter
A4V09_RS15105	COG1132	(ABC) transporter
A4V09_RS15115	COG0484	heat shock protein binding
A4V09_RS15120	COG0443	Heat shock 70 kDa protein
A4V09_RS15125	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A4V09_RS15130	COG1420	regulation of RNA biosynthetic process
A4V09_RS15140	COG1757	Na H antiporter
A4V09_RS15235	COG1013	pyruvate-flavodoxin oxidoreductase activity
A4V09_RS15245	COG2033	superoxide reductase activity
A4V09_RS15275	COG1082	Xylose isomerase domain protein TIM barrel
A4V09_RS15280	COG0673	inositol 2-dehydrogenase activity
A4V09_RS15285	COG1082	Xylose isomerase domain protein TIM barrel
A4V09_RS15290	COG2169	Transcriptional regulator
A4V09_RS15295	COG0235	Class ii aldolase
A4V09_RS15300	COG4806	L-rhamnose isomerase
A4V09_RS15305	COG1070	Carbohydrate kinase
A4V09_RS15315	COG3437	response regulator, receiver
A4V09_RS15325	COG0793	Belongs to the peptidase S41A family
A4V09_RS15330	COG2177	Part of the ABC transporter FtsEX involved in
A4V09_RS15335	COG2884	Cell division ATP-binding protein ftsE
A4V09_RS15340	COG3835	regulator
A4V09_RS15370	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A4V09_RS15380	COG0840	transmembrane signaling receptor activity
A4V09_RS15395	COG0840	transmembrane signaling receptor activity
A4V09_RS15400	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A4V09_RS15425	COG1597	lipid kinase activity
A4V09_RS15430	COG0203	ribosomal protein L17
A4V09_RS15435	COG0202	RNA polymerase activity
A4V09_RS15440	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A4V09_RS15445	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
A4V09_RS15450	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A4V09_RS15455	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A4V09_RS15460	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A4V09_RS15475	COG0563	adenylate kinase activity
A4V09_RS15485	COG0200	Binds to the 23S rRNA
A4V09_RS15495	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A4V09_RS15505	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A4V09_RS15510	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A4V09_RS15515	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A4V09_RS15535	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
A4V09_RS15540	COG0255	Belongs to the universal ribosomal protein uL29 family
A4V09_RS15545	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
A4V09_RS15555	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
A4V09_RS15565	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
A4V09_RS15580	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A4V09_RS15585	COG0051	transcription antitermination factor activity, RNA binding
A4V09_RS15590	COG0281	malic enzyme
A4V09_RS15600	COG1362	aminopeptidase activity
A4V09_RS15605	COG0383	alpha-mannosidase activity
A4V09_RS15615	COG1175	transmembrane transport
A4V09_RS15620	COG1653	transport
A4V09_RS15640	COG2972	Histidine kinase
A4V09_RS15650	COG2160	L-arabinose isomerase activity
A4V09_RS15660	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4V09_RS15665	COG1481	regulation of sporulation
A4V09_RS15680	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
A4V09_RS15700	COG2357	RelA SpoT domain protein
A4V09_RS15705	COG3250	beta-galactosidase activity
A4V09_RS15715	COG1653	transport
A4V09_RS15720	COG0395	ABC-type sugar transport system, permease component
A4V09_RS15725	COG4209	transmembrane transport
A4V09_RS15740	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A4V09_RS15750	COG1486	melibiose metabolic process
A4V09_RS15755	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A4V09_RS15760	COG0395	ABC-type sugar transport system, permease component
A4V09_RS15770	COG4209	transmembrane transport
A4V09_RS15780	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
A4V09_RS15780	COG1796	DNA polymerase
A4V09_RS15795	COG2972	Histidine kinase
A4V09_RS15800	COG2207	Transcriptional regulator
A4V09_RS15800	COG4753	response regulator
A4V09_RS15810	COG4753	response regulator
A4V09_RS15810	COG2207	Transcriptional regulator
A4V09_RS15815	COG3275	phosphorelay sensor kinase activity
A4V09_RS15845	COG2378	regulation of single-species biofilm formation
A4V09_RS15900	COG2340	Cysteine-rich secretory protein family
A4V09_RS15905	COG1983	PspC domain protein
A4V09_RS15930	COG1132	(ABC) transporter
A4V09_RS15940	COG3290	protein histidine kinase activity
A4V09_RS15950	COG1115	amino acid carrier protein
A4V09_RS15955	COG1074	ATP-dependent DNA helicase activity
A4V09_RS15960	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
A4V09_RS15965	COG0561	phosphatase activity
A4V09_RS16020	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
A4V09_RS16045	COG3275	phosphorelay sensor kinase activity
A4V09_RS16050	COG0395	ABC-type sugar transport system, permease component
A4V09_RS16055	COG4209	transmembrane transport
A4V09_RS16065	COG2755	lipolytic protein G-D-S-L family
A4V09_RS16065	COG0657	acetylesterase activity
A4V09_RS16085	COG2207	Transcriptional regulator
A4V09_RS16085	COG4753	response regulator
A4V09_RS16095	COG0395	ABC-type sugar transport system, permease component
A4V09_RS16100	COG4209	transmembrane transport
A4V09_RS16105	COG1472	Belongs to the glycosyl hydrolase 3 family
A4V09_RS16120	COG1501	Belongs to the glycosyl hydrolase 31 family
A4V09_RS16130	COG0426	domain, Protein
A4V09_RS16140	COG0791	NLP P60 protein
A4V09_RS16160	COG0437	4 iron, 4 sulfur cluster binding
A4V09_RS16160	COG3064	Membrane
A4V09_RS16165	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
A4V09_RS16175	COG0531	amino acid
A4V09_RS16180	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A4V09_RS16195	COG0657	acetylesterase activity
A4V09_RS16210	COG1362	aminopeptidase activity
A4V09_RS16215	COG0531	amino acid
A4V09_RS16220	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A4V09_RS16220	COG2080	2 iron, 2 sulfur cluster binding
A4V09_RS16235	COG0534	Mate efflux family protein
A4V09_RS16245	COG1691	(AIR) carboxylase
A4V09_RS16255	COG0534	Mate efflux family protein
A4V09_RS16260	COG3534	alpha-L-arabinofuranosidase
A4V09_RS16265	COG0395	ABC-type sugar transport system, permease component
A4V09_RS16270	COG1175	transmembrane transport
A4V09_RS16275	COG1653	transport
A4V09_RS16285	COG3534	alpha-L-arabinofuranosidase
A4V09_RS16295	COG3940	Belongs to the glycosyl hydrolase 43 family
A4V09_RS16300	COG1288	antiporter activity
A4V09_RS16325	COG0179	Fumarylacetoacetate (FAA) hydrolase
A4V09_RS16330	COG1522	sequence-specific DNA binding
A4V09_RS16340	COG1994	Peptidase M50
A4V09_RS16365	COG1511	domain protein
A4V09_RS16385	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A4V09_RS16395	COG1528	Iron-storage protein
A4V09_RS16405	COG2855	membrane
A4V09_RS16410	COG0583	DNA-binding transcription factor activity
A4V09_RS16425	COG3708	Transcriptional regulator
A4V09_RS16425	COG2207	Transcriptional regulator
A4V09_RS16430	COG1312	Catalyzes the dehydration of D-mannonate
A4V09_RS16435	COG0246	Mannitol dehydrogenase
A4V09_RS16450	COG5001	Diguanylate cyclase
A4V09_RS16450	COG3300	MHYT domain
A4V09_RS16515	COG4974	Belongs to the 'phage' integrase family
A4V09_RS16530	COG0656	L-ascorbic acid biosynthetic process
A4V09_RS16535	COG1063	alcohol dehydrogenase
A4V09_RS16540	COG3250	beta-galactosidase activity
A4V09_RS16550	COG3958	Transketolase
A4V09_RS16555	COG3959	Transketolase, thiamine diphosphate binding domain
A4V09_RS16580	COG3275	phosphorelay sensor kinase activity
A4V09_RS16585	COG1501	Belongs to the glycosyl hydrolase 31 family
A4V09_RS16590	COG1874	Beta-galactosidase
A4V09_RS16610	COG0395	ABC-type sugar transport system, permease component
A4V09_RS16615	COG4209	transmembrane transport
A4V09_RS16670	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
A4V09_RS16675	COG1053	succinate dehydrogenase
A4V09_RS16705	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
A4V09_RS16720	COG0039	L-malate dehydrogenase activity
A4V09_RS16725	COG2205	protein histidine kinase activity
A4V09_RS16730	COG0745	RESPONSE REGULATOR receiver
A4V09_RS16790	COG0366	Alpha amylase catalytic
A4V09_RS16795	COG0395	ABC-type sugar transport system, permease component
A4V09_RS16800	COG1175	transmembrane transport
A4V09_RS16805	COG1653	transport
A4V09_RS16810	COG1609	Transcriptional regulator
A4V09_RS16840	COG3958	Transketolase
A4V09_RS16845	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
A4V09_RS16855	COG1609	Transcriptional regulator
A4V09_RS16860	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A4V09_RS16865	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
A4V09_RS16870	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A4V09_RS16875	COG0205	6-phosphofructokinase activity
A4V09_RS16890	COG0586	Pfam SNARE associated Golgi protein
A4V09_RS16895	COG0646	methionine synthase
A4V09_RS16895	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
A4V09_RS16900	COG0590	tRNA wobble adenosine to inosine editing
A4V09_RS16935	COG1609	Transcriptional regulator
A4V09_RS16940	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A4V09_RS16940	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
A4V09_RS16960	COG2088	sporulation resulting in formation of a cellular spore
A4V09_RS16965	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
A4V09_RS16970	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
A4V09_RS16990	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A4V09_RS17010	COG0017	Asparaginyl-tRNA synthetase
A4V09_RS17025	COG0445	tRNA wobble uridine modification
A4V09_RS17030	COG0395	ABC-type sugar transport system, permease component
A4V09_RS17035	COG1175	transmembrane transport
A4V09_RS17045	COG4753	response regulator
A4V09_RS17045	COG2207	Transcriptional regulator
A4V09_RS17050	COG3275	phosphorelay sensor kinase activity
A4V09_RS17080	COG0768	penicillin binding
A4V09_RS17085	COG0544	peptidyl-prolyl cis-trans isomerase activity
A4V09_RS17100	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A4V09_RS17115	COG0697	spore germination
A4V09_RS17120	COG1802	Transcriptional regulator
A4V09_RS17125	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
A4V09_RS17145	COG0534	Mate efflux family protein
A4V09_RS17155	COG0534	Mate efflux family protein
A4V09_RS17165	COG1518	maintenance of DNA repeat elements
A4V09_RS17195	COG3842	ATPase activity
A4V09_RS17270	COG0110	maltose O-acetyltransferase activity
A4V09_RS17275	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A4V09_RS17285	COG1181	Belongs to the D-alanine--D-alanine ligase family
A4V09_RS17295	COG0456	acetyltransferase
A4V09_RS17300	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A4V09_RS17305	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A4V09_RS17320	COG0582	viral genome integration into host DNA
A4V09_RS17325	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A4V09_RS17340	COG2207	Transcriptional regulator
A4V09_RS17360	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A4V09_RS17370	COG0116	Belongs to the methyltransferase superfamily
A4V09_RS17370	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A4V09_RS17380	COG5002	protein histidine kinase activity
A4V09_RS17380	COG3850	Histidine kinase
A4V09_RS17395	COG0252	asparaginase activity
A4V09_RS17410	COG2205	protein histidine kinase activity
A4V09_RS17420	COG2197	response regulator
A4V09_RS17435	COG3426	butyrate kinase activity
A4V09_RS17450	COG0657	acetylesterase activity
A4V09_RS17485	COG0457	Tetratricopeptide repeat
A4V09_RS17490	COG1966	Carbon starvation protein
A4V09_RS17505	COG1151	hydroxylamine reductase activity
A4V09_RS17520	COG1509	lysine 2,3-aminomutase activity
A4V09_RS17540	COG5001	Diguanylate cyclase
A4V09_RS17550	COG1028	Short-chain dehydrogenase reductase Sdr
A4V09_RS17555	COG3958	Transketolase
A4V09_RS17560	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
A4V09_RS17570	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
A4V09_RS17575	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A4V09_RS17585	COG1595	DNA-templated transcription, initiation
A4V09_RS17595	COG0577	efflux transmembrane transporter activity
A4V09_RS17595	COG1136	(ABC) transporter
A4V09_RS17605	COG0745	RESPONSE REGULATOR receiver
A4V09_RS17615	COG3655	Transcriptional regulator
A4V09_RS17645	COG1609	Transcriptional regulator
A4V09_RS17660	COG0534	Mate efflux family protein
A4V09_RS17665	COG1653	transport
A4V09_RS17670	COG0395	ABC-type sugar transport system, permease component
A4V09_RS17680	COG3250	beta-galactosidase activity
A4V09_RS17685	COG1609	Transcriptional regulator
A4V09_RS17690	COG2222	sugar isomerase
A4V09_RS17695	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A4V09_RS17705	COG2188	Transcriptional regulator
A4V09_RS17715	COG1695	Transcriptional regulator
A4V09_RS17720	COG2207	Transcriptional regulator
A4V09_RS17720	COG1917	Cupin 2, conserved barrel domain protein
A4V09_RS17725	COG0534	Mate efflux family protein
A4V09_RS17730	COG0110	maltose O-acetyltransferase activity
A4V09_RS17745	COG0395	ABC-type sugar transport system, permease component
A4V09_RS17750	COG4209	transmembrane transport
A4V09_RS17760	COG0745	RESPONSE REGULATOR receiver
A4V09_RS17765	COG5002	protein histidine kinase activity
A4V09_RS17775	COG1136	(ABC) transporter
A4V09_RS17780	COG2201	protein-glutamate methylesterase activity
A4V09_RS17795	COG1193	negative regulation of DNA recombination
A4V09_RS17810	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A4V09_RS17815	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A4V09_RS17820	COG0049	tRNA binding
A4V09_RS17825	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
A4V09_RS17835	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A4V09_RS17840	COG0085	RNA polymerase activity
A4V09_RS17855	COG3620	sequence-specific DNA binding
A4V09_RS17860	COG0222	ribosome binding
A4V09_RS17880	COG1388	LysM domain
A4V09_RS17880	COG3858	chitin binding
A4V09_RS17890	COG4974	Belongs to the 'phage' integrase family
A4V09_RS17900	COG0081	regulation of translation
A4V09_RS17910	COG0250	Participates in transcription elongation, termination and antitermination
A4V09_RS17920	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A4V09_RS17945	COG1073	alpha beta
A4V09_RS17950	COG2723	6-phospho-beta-galactosidase activity
A4V09_RS17965	COG0673	inositol 2-dehydrogenase activity
A4V09_RS17970	COG1028	Short-chain dehydrogenase reductase Sdr
A4V09_RS17975	COG1175	transmembrane transport
A4V09_RS17980	COG0395	ABC-type sugar transport system, permease component
A4V09_RS17990	COG0346	lactoylglutathione lyase activity
A4V09_RS18000	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A4V09_RS18005	COG4608	Belongs to the ABC transporter superfamily
A4V09_RS18010	COG0444	Belongs to the ABC transporter superfamily
A4V09_RS18020	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A4V09_RS18025	COG0601	transmembrane transport
A4V09_RS18030	COG0747	negative chemotaxis
A4V09_RS18050	COG1228	amidohydrolase
A4V09_RS18080	COG4978	Transcriptional regulator
A4V09_RS18080	COG0789	Transcriptional regulator
A4V09_RS18090	COG1136	(ABC) transporter
A4V09_RS18100	COG0745	RESPONSE REGULATOR receiver
A4V09_RS18135	COG1401	restriction endodeoxyribonuclease activity
A4V09_RS18145	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A4V09_RS18145	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A4V09_RS18205	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A4V09_RS18290	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A4V09_RS18405	COG1733	regulation of RNA biosynthetic process
A4V09_RS18415	COG0640	Transcriptional regulator
A4V09_RS18420	COG0640	Transcriptional regulator
A4V09_RS18425	COG2217	Heavy metal translocating P-type atpase
A4V09_RS18440	COG1937	Protein conserved in bacteria
A4V09_RS18445	COG0534	Mate efflux family protein
A4V09_RS18465	COG1733	regulation of RNA biosynthetic process
A4V09_RS18485	COG4509	Sortase family
A4V09_RS18495	COG1309	transcriptional regulator
A4V09_RS18505	COG2814	Major facilitator Superfamily
A4V09_RS18525	COG1396	sequence-specific DNA binding
A4V09_RS18560	COG0842	Transport permease protein
A4V09_RS18560	COG1129	ABC transporter
A4V09_RS18575	COG2239	Acts as a magnesium transporter
A4V09_RS18580	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A4V09_RS18590	COG5002	protein histidine kinase activity
A4V09_RS18595	COG0745	RESPONSE REGULATOR receiver
A4V09_RS18625	COG0483	inositol monophosphate 1-phosphatase activity
A4V09_RS18645	COG0745	RESPONSE REGULATOR receiver
A4V09_RS18650	COG2378	regulation of single-species biofilm formation
A4V09_RS18660	COG0534	Mate efflux family protein
A4V09_RS18675	COG1309	transcriptional regulator
A4V09_RS18715	COG0745	RESPONSE REGULATOR receiver
A4V09_RS18720	COG5002	protein histidine kinase activity
A4V09_RS18725	COG1136	(ABC) transporter
A4V09_RS18765	COG0577	efflux transmembrane transporter activity
A4V09_RS18770	COG1136	(ABC) transporter
A4V09_RS18775	COG5002	protein histidine kinase activity
A4V09_RS18855	COG0483	inositol monophosphate 1-phosphatase activity
A4V09_RS18890	COG4474	Belongs to the UPF0398 family
A4V09_RS18900	COG0681	Belongs to the peptidase S26 family
A4V09_RS18920	COG3177	Filamentation induced by cAMP protein fic
A4V09_RS19005	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
A4V09_RS19010	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A4V09_RS19015	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A4V09_RS19020	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
A4V09_RS19030	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
A4V09_RS19030	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
A4V09_RS19035	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A4V09_RS19060	COG1136	(ABC) transporter
A4V09_RS19065	COG2252	PERMEase
A4V09_RS19070	COG2205	protein histidine kinase activity
A4V09_RS19090	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A4V09_RS19095	COG0569	domain protein
A4V09_RS19100	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A4V09_RS19115	COG0500	methyltransferase
A4V09_RS19120	COG2996	Protein conserved in bacteria
A4V09_RS19140	COG3279	Response regulator of the LytR AlgR family
A4V09_RS19195	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A4V09_RS19200	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
A4V09_RS19210	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A4V09_RS19220	COG1830	Aldolase
A4V09_RS19225	COG1063	alcohol dehydrogenase
A4V09_RS19230	COG1737	Transcriptional regulator
A4V09_RS19235	COG1876	peptidase activity
A4V09_RS19240	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
A4V09_RS19245	COG2002	toxin-antitoxin pair type II binding
A4V09_RS19255	COG4750	Nucleotidyl transferase
A4V09_RS19260	COG1213	nucleotidyl transferase
A4V09_RS19270	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
A4V09_RS19280	COG1486	melibiose metabolic process
A4V09_RS19285	COG2207	Transcriptional regulator
A4V09_RS19305	COG1486	melibiose metabolic process
A4V09_RS19315	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
A4V09_RS19320	COG2207	Transcriptional regulator
A4V09_RS19350	COG1216	Glycosyl transferase, family 2
A4V09_RS19355	COG1215	transferase activity, transferring glycosyl groups
A4V09_RS19365	COG0463	Glycosyl transferase, family 2
A4V09_RS19365	COG1216	Glycosyl transferase, family 2
A4V09_RS19370	COG1216	Glycosyl transferase, family 2
A4V09_RS19380	COG3475	LICD family
A4V09_RS19395	COG0438	transferase activity, transferring glycosyl groups
A4V09_RS19410	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A4V09_RS19420	COG4509	Sortase family
A4V09_RS19440	COG3944	biosynthesis protein
A4V09_RS19465	COG2207	Transcriptional regulator
A4V09_RS19475	COG0395	ABC-type sugar transport system, permease component
A4V09_RS19480	COG1175	transmembrane transport
A4V09_RS19505	COG1175	transmembrane transport
A4V09_RS19520	COG1940	carbohydrate kinase activity
A4V09_RS19530	COG0673	inositol 2-dehydrogenase activity
A4V09_RS19535	COG0366	Alpha amylase catalytic
A4V09_RS19540	COG0395	ABC-type sugar transport system, permease component
A4V09_RS19565	COG5012	cobalamin binding
A4V09_RS19585	COG5012	cobalamin binding
A4V09_RS19595	COG3835	regulator
A4V09_RS19610	COG0110	maltose O-acetyltransferase activity
A4V09_RS19615	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A4V09_RS19625	COG2205	protein histidine kinase activity
A4V09_RS19625	COG0784	Response regulator, receiver
A4V09_RS19650	COG1940	carbohydrate kinase activity
A4V09_RS19650	COG1846	Transcriptional regulator
A4V09_RS19655	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A4V09_RS19665	COG1592	Rubrerythrin
A4V09_RS19670	COG1773	rubredoxin
A4V09_RS19670	COG1592	Rubrerythrin
A4V09_RS19675	COG0735	belongs to the Fur family
A4V09_RS19680	COG1737	Transcriptional regulator
A4V09_RS19690	COG2731	YhcH YjgK YiaL family protein
A4V09_RS19695	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A4V09_RS19700	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A4V09_RS19705	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
A4V09_RS19710	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
A4V09_RS19720	COG0791	NLP P60 protein
A4V09_RS19735	COG0275	rRNA processing
A4V09_RS19740	COG2873	o-acetylhomoserine
A4V09_RS19745	COG0534	Mate efflux family protein
A4V09_RS19820	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A4V09_RS19825	COG0187	DNA topoisomerase II activity
A4V09_RS19830	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A4V09_RS19840	COG0592	DNA-directed DNA polymerase activity
A4V09_RS19845	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A4V09_RS19850	COG0230	Belongs to the bacterial ribosomal protein bL34 family
A4V09_RS19855	COG0594	ribonuclease P activity
A4V09_RS19860	COG0706	membrane insertase activity
A4V09_RS19865	COG1847	R3H domain protein
A4V09_RS19870	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A4V09_RS19875	COG0445	tRNA wobble uridine modification
A4V09_RS19880	COG0357	Ribosomal RNA small subunit methyltransferase G
A4V09_RS19905	COG1131	(ABC) transporter
A4V09_RS19935	COG1192	Involved in chromosome partitioning
A4V09_RS19940	COG1475	DNA binding
A4V09_RS19950	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A4V09_RS19960	COG5002	protein histidine kinase activity
A4V09_RS19960	COG5001	Diguanylate cyclase
A4V09_RS19965	COG2972	Histidine kinase
A4V09_RS19970	COG4753	response regulator
A4V09_RS19970	COG2207	Transcriptional regulator
A4V09_RS19985	COG0395	ABC-type sugar transport system, permease component
A4V09_RS20005	COG1396	sequence-specific DNA binding
A4V09_RS20025	COG0004	ammonium transporteR
A4V09_RS20030	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
A4V09_RS20050	COG0504	CTP synthase activity
A4V09_RS20055	COG0070	glutamate synthase
A4V09_RS20055	COG0067	glutamate synthase
A4V09_RS20055	COG0069	glutamate synthase activity
A4V09_RS20060	COG0493	'glutamate synthase
A4V09_RS20070	COG0514	ATP-dependent DNA helicase (RecQ)
A4V09_RS20085	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
A4V09_RS20090	COG1459	type II secretion system
A4V09_RS20105	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A4V09_RS20145	COG0436	Aminotransferase
A4V09_RS20150	COG0017	Asparaginyl-tRNA synthetase
A4V09_RS20155	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A4V09_RS20170	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A4V09_RS20175	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A4V09_RS20190	COG1686	Belongs to the peptidase S11 family
A4V09_RS20200	COG1131	(ABC) transporter
A4V09_RS20220	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A4V09_RS20225	COG0058	SHG alpha-glucan phosphorylase activity
A4V09_RS20235	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A4V09_RS20240	COG3842	ATPase activity
A4V09_RS20260	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A4V09_RS20260	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A4V09_RS20270	COG3250	beta-galactosidase activity
A4V09_RS20275	COG2211	Major facilitator Superfamily
A4V09_RS20285	COG4086	secreted protein
A4V09_RS20290	COG2357	RelA SpoT domain protein
A4V09_RS20315	COG1501	Belongs to the glycosyl hydrolase 31 family
A4V09_RS20320	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A4V09_RS20325	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A4V09_RS20330	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A4V09_RS20355	COG3708	Transcriptional regulator
A4V09_RS20355	COG2207	Transcriptional regulator
A4V09_RS20365	COG1175	transmembrane transport
A4V09_RS20370	COG0395	ABC-type sugar transport system, permease component
A4V09_RS20380	COG1063	alcohol dehydrogenase
A4V09_RS20390	COG2610	gluconate transmembrane transporter activity
A4V09_RS20395	COG2186	Transcriptional regulator
A4V09_RS20400	COG0129	dihydroxy-acid dehydratase activity
A4V09_RS20405	COG1028	Short-chain dehydrogenase reductase Sdr
A4V09_RS20410	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A4V09_RS20425	COG5002	protein histidine kinase activity
A4V09_RS20430	COG0745	RESPONSE REGULATOR receiver
A4V09_RS20465	COG0442	prolyl-tRNA aminoacylation
A4V09_RS20470	COG1982	Orn Lys Arg decarboxylase major
A4V09_RS20470	COG1982	Orn Lys Arg decarboxylase major
A4V09_RS20475	COG0194	GDP metabolic process
A4V09_RS20485	COG1774	PSP1 C-terminal conserved region
A4V09_RS20490	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
A4V09_RS20495	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
A4V09_RS20500	COG2843	Capsule synthesis protein
A4V09_RS20505	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A4V09_RS20510	COG2715	membrane protein required for spore maturation
A4V09_RS20515	COG1609	Transcriptional regulator
A4V09_RS20520	COG1609	Transcriptional regulator
A4V09_RS20530	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A4V09_RS20535	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A4V09_RS20550	COG1028	Short-chain dehydrogenase reductase Sdr
A4V09_RS20555	COG3959	Transketolase, thiamine diphosphate binding domain
A4V09_RS20560	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A4V09_RS20565	COG1063	alcohol dehydrogenase
A4V09_RS20570	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A4V09_RS20580	COG0149	triose-phosphate isomerase activity
A4V09_RS20600	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A4V09_RS20605	COG0069	glutamate synthase activity
A4V09_RS20610	COG0534	Mate efflux family protein
A4V09_RS20635	COG0395	ABC-type sugar transport system, permease component
A4V09_RS20640	COG2207	Transcriptional regulator
A4V09_RS20640	COG4753	response regulator
A4V09_RS20645	COG2972	Histidine kinase
A4V09_RS20665	COG2207	Transcriptional regulator
A4V09_RS20665	COG1917	Cupin 2, conserved barrel domain protein
A4V09_RS20670	COG0673	inositol 2-dehydrogenase activity
A4V09_RS20675	COG1082	Xylose isomerase domain protein TIM barrel
A4V09_RS20680	COG1082	Xylose isomerase domain protein TIM barrel
A4V09_RS20685	COG2211	Major facilitator Superfamily
A4V09_RS20695	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A4V09_RS20695	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A4V09_RS20710	COG1486	melibiose metabolic process
A4V09_RS20715	COG2971	BadF BadG BcrA BcrD
A4V09_RS20725	COG1175	transmembrane transport
A4V09_RS20730	COG0395	ABC-type sugar transport system, permease component
A4V09_RS20735	COG0363	glucosamine-6-phosphate deaminase activity
A4V09_RS20755	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A4V09_RS20760	COG0628	permease
A4V09_RS20765	COG0084	hydrolase, TatD family'
A4V09_RS20770	COG1309	transcriptional regulator
A4V09_RS20785	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A4V09_RS20790	COG0631	protein serine/threonine phosphatase activity
A4V09_RS20910	COG0352	thiamine-phosphate diphosphorylase activity
A4V09_RS20920	COG2022	thiamine diphosphate biosynthetic process
A4V09_RS20925	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A4V09_RS20930	COG2104	thiamine diphosphate biosynthetic process
A4V09_RS20935	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
A4V09_RS20945	COG4977	sequence-specific DNA binding
A4V09_RS20960	COG1757	Na H antiporter
A4V09_RS20965	COG0745	RESPONSE REGULATOR receiver
A4V09_RS20975	COG1136	(ABC) transporter
A4V09_RS20985	COG0523	cobalamin synthesis protein
A4V09_RS21000	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A4V09_RS21020	COG2059	Chromate
A4V09_RS21045	COG0700	Nucleoside recognition
A4V09_RS21050	COG2198	Histidine kinase
A4V09_RS21050	COG2205	protein histidine kinase activity
A4V09_RS21050	COG0784	Response regulator, receiver
A4V09_RS21055	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
A4V09_RS21060	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
A4V09_RS21065	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A4V09_RS21070	COG0131	Imidazoleglycerol-phosphate dehydratase
A4V09_RS21075	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
A4V09_RS21085	COG0107	imidazoleglycerol-phosphate synthase activity
A4V09_RS21090	COG0140	phosphoribosyl-ATP diphosphatase activity
A4V09_RS21090	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
A4V09_RS21095	COG0140	phosphoribosyl-ATP diphosphatase activity
A4V09_RS21110	COG1175	transmembrane transport
A4V09_RS21115	COG0395	ABC-type sugar transport system, permease component
A4V09_RS21120	COG1486	melibiose metabolic process
A4V09_RS21130	COG1063	alcohol dehydrogenase
A4V09_RS21140	COG4869	propanediol catabolic process
A4V09_RS21150	COG1105	Belongs to the carbohydrate kinase PfkB family
A4V09_RS21155	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4V09_RS21155	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A4V09_RS21155	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A4V09_RS21165	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A4V09_RS21170	COG1349	DNA-binding transcription factor activity
A4V09_RS21205	COG0492	ferredoxin-NADP+ reductase activity
A4V09_RS21210	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
A4V09_RS21215	COG5002	protein histidine kinase activity
A4V09_RS21225	COG0704	Plays a role in the regulation of phosphate uptake
A4V09_RS21230	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A4V09_RS21235	COG0581	inorganic phosphate transmembrane transporter activity
A4V09_RS21240	COG0573	inorganic phosphate transmembrane transporter activity
A4V09_RS21250	COG5002	protein histidine kinase activity
A4V09_RS21255	COG1394	ATPase activity, coupled to movement of substances
A4V09_RS21265	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
A4V09_RS21285	COG1269	ATP hydrolysis coupled proton transport
A4V09_RS21300	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A4V09_RS21410	COG0733	neurotransmitter:sodium symporter activity
A4V09_RS21415	COG2201	protein-glutamate methylesterase activity
A4V09_RS21420	COG3275	phosphorelay sensor kinase activity
A4V09_RS21450	COG0281	malic enzyme
A4V09_RS21480	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A4V09_RS21545	COG1716	ATPase activity
A4V09_RS21550	COG0457	Tetratricopeptide repeat
A4V09_RS21550	COG0705	Rhomboid family
A4V09_RS21555	COG5002	protein histidine kinase activity
A4V09_RS21560	COG0537	adenosine 5'-monophosphoramidase activity
A4V09_RS21570	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A4V09_RS21605	COG1695	Transcriptional regulator
A4V09_RS21620	COG2197	response regulator
A4V09_RS21625	COG4585	Histidine kinase
A4V09_RS21630	COG1131	(ABC) transporter
A4V09_RS21665	COG1131	(ABC) transporter
A4V09_RS21690	COG3279	Response regulator of the LytR AlgR family
A4V09_RS21780	COG0129	dihydroxy-acid dehydratase activity
A4V09_RS21795	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A4V09_RS21800	COG1104	cysteine desulfurase activity
A4V09_RS21815	COG2226	methyltransferase
A4V09_RS21825	COG1233	COG1233 Phytoene dehydrogenase and related
A4V09_RS21840	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A4V09_RS21845	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A4V09_RS21855	COG0166	Belongs to the GPI family
A4V09_RS21875	COG5002	protein histidine kinase activity
A4V09_RS21880	COG3842	ATPase activity
A4V09_RS21885	COG3835	regulator
A4V09_RS21890	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
A4V09_RS21895	COG0564	pseudouridine synthase activity
A4V09_RS21905	COG1879	ABC-type sugar transport system periplasmic component
A4V09_RS21915	COG1269	ATP hydrolysis coupled proton transport
A4V09_RS21920	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A4V09_RS21935	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
A4V09_RS21940	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
A4V09_RS21945	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
A4V09_RS21950	COG1394	ATPase activity, coupled to movement of substances
A4V09_RS21955	COG2223	nitrite transmembrane transporter activity
A4V09_RS21975	COG1472	Belongs to the glycosyl hydrolase 3 family
A4V09_RS21985	COG2706	6-phosphogluconolactonase activity
A4V09_RS21990	COG0534	Mate efflux family protein
A4V09_RS21995	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
A4V09_RS22000	COG0658	competence protein
A4V09_RS22000	COG2333	competence protein COMEC
A4V09_RS22010	COG1609	Transcriptional regulator
A4V09_RS22020	COG0519	Catalyzes the synthesis of GMP from XMP
A4V09_RS22070	COG0582	viral genome integration into host DNA
A4V09_RS22080	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
A4V09_RS22135	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A4V09_RS22145	COG1940	carbohydrate kinase activity
A4V09_RS22150	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
A4V09_RS22160	COG0546	phosphoglycolate phosphatase activity
A4V09_RS22165	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A4V09_RS22185	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A4V09_RS22190	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A4V09_RS22195	COG0535	radical SAM domain protein
A4V09_RS22225	COG0463	Glycosyl transferase, family 2
A4V09_RS22225	COG1216	Glycosyl transferase, family 2
A4V09_RS22230	COG0318	PFAM AMP-dependent synthetase and ligase
A4V09_RS22240	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A4V09_RS22245	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
A4V09_RS22245	COG1605	Chorismate mutase
A4V09_RS22250	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A4V09_RS22255	COG1131	(ABC) transporter
A4V09_RS22270	COG1484	DNA-dependent DNA replication
A4V09_RS22320	COG3550	peptidyl-serine autophosphorylation
A4V09_RS22365	COG1609	Transcriptional regulator
A4V09_RS22370	COG4209	transmembrane transport
A4V09_RS22375	COG0395	ABC-type sugar transport system, permease component
A4V09_RS22405	COG4753	response regulator
A4V09_RS22405	COG2207	Transcriptional regulator
A4V09_RS22410	COG2972	Histidine kinase
A4V09_RS22420	COG1175	transmembrane transport
A4V09_RS22450	COG2972	Histidine kinase
A4V09_RS22455	COG4753	response regulator
A4V09_RS22455	COG2207	Transcriptional regulator
A4V09_RS22465	COG1175	transmembrane transport
A4V09_RS22470	COG0395	ABC-type sugar transport system, permease component
A4V09_RS22490	COG0737	Belongs to the 5'-nucleotidase family
A4V09_RS22500	COG1309	transcriptional regulator
A4V09_RS22505	COG1131	(ABC) transporter
A4V09_RS22515	COG2814	Major facilitator Superfamily
A4V09_RS22520	COG2267	carboxylic ester hydrolase activity
A4V09_RS22560	COG1595	DNA-templated transcription, initiation
A4V09_RS22570	COG1131	(ABC) transporter
A4V09_RS22600	COG3275	phosphorelay sensor kinase activity
A4V09_RS22605	COG4753	response regulator
A4V09_RS22605	COG2207	Transcriptional regulator
A4V09_RS22610	COG1472	Belongs to the glycosyl hydrolase 3 family
A4V09_RS22625	COG0745	RESPONSE REGULATOR receiver
A4V09_RS22630	COG5002	protein histidine kinase activity
A4V09_RS22650	COG1971	Probably functions as a manganese efflux pump
A4V09_RS22660	COG1115	amino acid carrier protein
A4V09_RS22665	COG0726	polysaccharide deacetylase
A4V09_RS22675	COG1012	belongs to the aldehyde dehydrogenase family
A4V09_RS22675	COG1454	alcohol dehydrogenase
A4V09_RS22680	COG1217	gtp-binding protein TYPA
A4V09_RS22690	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
A4V09_RS22695	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A4V09_RS22700	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
A4V09_RS22710	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
A4V09_RS22715	COG1924	4 iron, 4 sulfur cluster binding
A4V09_RS22720	COG0653	protein targeting
A4V09_RS22730	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
A4V09_RS22735	COG4492	Belongs to the UPF0735 family
A4V09_RS22740	COG0460	homoserine dehydrogenase
A4V09_RS22745	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
A4V09_RS22770	COG1070	Carbohydrate kinase
A4V09_RS22775	COG2183	response to ionizing radiation
A4V09_RS22780	COG0006	proline dipeptidase activity
A4V09_RS22795	COG4753	response regulator
A4V09_RS22795	COG2207	Transcriptional regulator
A4V09_RS22800	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A4V09_RS22800	COG2207	Transcriptional regulator
A4V09_RS22805	COG1609	Transcriptional regulator
A4V09_RS22810	COG4209	transmembrane transport
A4V09_RS22815	COG0395	ABC-type sugar transport system, permease component
A4V09_RS22830	COG2207	Transcriptional regulator
A4V09_RS22835	COG0534	Mate efflux family protein
A4V09_RS22840	COG3250	beta-galactosidase activity
A4V09_RS22895	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
A4V09_RS22900	COG1028	Short-chain dehydrogenase reductase Sdr
A4V09_RS22920	COG2207	Transcriptional regulator
A4V09_RS22920	COG4753	response regulator
A4V09_RS22925	COG2972	Histidine kinase
A4V09_RS22935	COG1175	transmembrane transport
A4V09_RS22940	COG0395	ABC-type sugar transport system, permease component
A4V09_RS22955	COG2161	toxin-antitoxin pair type II binding
A4V09_RS22965	COG1396	sequence-specific DNA binding
A4V09_RS22970	COG1309	transcriptional regulator
A4V09_RS22980	COG0582	viral genome integration into host DNA
A4V09_RS22985	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
A4V09_RS22995	COG0628	permease
A4V09_RS23000	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A4V09_RS23005	COG0569	domain protein
A4V09_RS23010	COG2205	protein histidine kinase activity
A4V09_RS23015	COG0745	RESPONSE REGULATOR receiver
A4V09_RS23025	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
A4V09_RS23035	COG1696	Membrane protein involved in D-alanine export
A4V09_RS23040	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A4V09_RS23050	COG2759	Belongs to the formate--tetrahydrofolate ligase family
A4V09_RS23055	COG2116	formate transmembrane transporter activity
A4V09_RS23065	COG1132	(ABC) transporter
A4V09_RS23070	COG0436	Aminotransferase
A4V09_RS23085	COG1940	carbohydrate kinase activity
A4V09_RS23090	COG1653	transport
A4V09_RS23095	COG1175	transmembrane transport
A4V09_RS23110	COG1940	carbohydrate kinase activity
A4V09_RS23115	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
A4V09_RS23120	COG3250	beta-galactosidase activity
A4V09_RS23125	COG1609	Transcriptional regulator
A4V09_RS23145	COG1501	Belongs to the glycosyl hydrolase 31 family
A4V09_RS23165	COG0622	Phosphoesterase
A4V09_RS23170	COG0116	Belongs to the methyltransferase superfamily
A4V09_RS23175	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A4V09_RS23180	COG0622	Phosphoesterase
A4V09_RS23220	COG2801	Transposase and inactivated derivatives
A4V09_RS23265	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
A4V09_RS23300	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A4V09_RS23305	COG3962	Belongs to the TPP enzyme family
A4V09_RS23325	COG2211	Major facilitator Superfamily
A4V09_RS23335	COG0673	inositol 2-dehydrogenase activity
A4V09_RS23340	COG3275	phosphorelay sensor kinase activity
A4V09_RS23345	COG2207	Transcriptional regulator
A4V09_RS23345	COG4753	response regulator
A4V09_RS23375	COG0673	inositol 2-dehydrogenase activity
A4V09_RS23380	COG1082	Xylose isomerase domain protein TIM barrel
A4V09_RS23385	COG1349	DNA-binding transcription factor activity
A4V09_RS23390	COG2223	nitrite transmembrane transporter activity
A4V09_RS23405	COG0662	Cupin 2, conserved barrel domain protein
A4V09_RS23405	COG2207	Transcriptional regulator
A4V09_RS23420	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A4V09_RS23430	COG2986	histidine ammonia-lyase
A4V09_RS23435	COG1757	Na H antiporter
A4V09_RS23445	COG1773	rubredoxin
A4V09_RS23450	COG0583	DNA-binding transcription factor activity
A4V09_RS23455	COG0446	pyridine nucleotide-disulphide oxidoreductase
A4V09_RS23465	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
A4V09_RS23470	COG0534	Mate efflux family protein
A4V09_RS23475	COG1328	CTP reductase activity
A4V09_RS23480	COG0475	glutathione-regulated potassium exporter activity
A4V09_RS23500	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A4V09_RS23510	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A4V09_RS23520	COG5002	protein histidine kinase activity
A4V09_RS23525	COG0745	RESPONSE REGULATOR receiver
A4V09_RS23530	COG1193	negative regulation of DNA recombination
A4V09_RS23535	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A4V09_RS23540	COG3481	metal-dependent phosphohydrolase, HD sub domain
A4V09_RS23545	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A4V09_RS23615	COG4166	transmembrane transport
A4V09_RS23620	COG0601	transmembrane transport
A4V09_RS23625	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A4V09_RS23630	COG0444	Belongs to the ABC transporter superfamily
A4V09_RS23635	COG4608	Belongs to the ABC transporter superfamily
A4V09_RS23645	COG1349	DNA-binding transcription factor activity