locus-tag	class	description
A4V09_RS00020	COG3250	beta-galactosidase activity
A4V09_RS00030	COG4209	transmembrane transport
A4V09_RS00035	COG0395	ABC-type sugar transport system, permease component
A4V09_RS00060	COG3275	phosphorelay sensor kinase activity
A4V09_RS00065	COG4753	response regulator
A4V09_RS00065	COG2207	Transcriptional regulator
A4V09_RS00080	COG1175	transmembrane transport
A4V09_RS00085	COG0395	ABC-type sugar transport system, permease component
A4V09_RS00140	COG2706	6-phosphogluconolactonase activity
A4V09_RS00145	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
A4V09_RS00150	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A4V09_RS00155	COG3620	sequence-specific DNA binding
A4V09_RS00170	COG1121	(ABC) transporter
A4V09_RS00180	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
A4V09_RS00190	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
A4V09_RS00195	COG1687	branched-chain amino acid
A4V09_RS00215	COG2252	PERMEase
A4V09_RS00220	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
A4V09_RS00225	COG0431	NADPH-dependent FMN reductase
A4V09_RS00235	COG0582	viral genome integration into host DNA
A4V09_RS00240	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A4V09_RS00245	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A4V09_RS00250	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A4V09_RS00285	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
A4V09_RS00290	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
A4V09_RS00295	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
A4V09_RS00300	COG2205	protein histidine kinase activity
A4V09_RS00370	COG2205	protein histidine kinase activity
A4V09_RS00380	COG0534	Mate efflux family protein
A4V09_RS00385	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A4V09_RS00395	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
A4V09_RS00405	COG0157	Belongs to the NadC ModD family
A4V09_RS00410	COG1827	regulation of RNA biosynthetic process
A4V09_RS00415	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A4V09_RS00445	COG0456	acetyltransferase
A4V09_RS00450	COG1283	sodium-dependent phosphate transmembrane transporter activity
A4V09_RS00460	COG5002	protein histidine kinase activity
A4V09_RS00485	COG3546	catalase activity
A4V09_RS00495	COG0569	domain protein
A4V09_RS00505	COG2217	Heavy metal translocating P-type atpase
A4V09_RS00520	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
A4V09_RS00530	COG1476	TRANSCRIPTIONal
A4V09_RS00540	COG4152	abc transporter atp-binding protein
A4V09_RS00545	COG1668	transmembrane transport
A4V09_RS00550	COG0363	glucosamine-6-phosphate deaminase activity
A4V09_RS00865	COG3646	Phage regulatory protein
A4V09_RS00905	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A4V09_RS00910	COG4868	Belongs to the UPF0371 family
A4V09_RS00915	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A4V09_RS00920	COG0322	excinuclease ABC activity
A4V09_RS00925	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
A4V09_RS00930	COG1940	carbohydrate kinase activity
A4V09_RS00940	COG1739	Uncharacterized protein family UPF0029
A4V09_RS00945	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A4V09_RS00950	COG0802	atpase or kinase
A4V09_RS00955	COG1214	PFAM Peptidase M22, glycoprotease
A4V09_RS00960	COG0456	acetyltransferase
A4V09_RS00970	COG1234	tRNA 3'-trailer cleavage
A4V09_RS00980	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
A4V09_RS01045	COG0242	peptide deformylase activity
A4V09_RS01060	COG0745	RESPONSE REGULATOR receiver
A4V09_RS01075	COG2205	protein histidine kinase activity
A4V09_RS01115	COG2508	Transcriptional regulator
A4V09_RS01115	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
A4V09_RS01135	COG5002	protein histidine kinase activity
A4V09_RS01170	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A4V09_RS01185	COG1131	(ABC) transporter
A4V09_RS01220	COG1131	(ABC) transporter
A4V09_RS01245	COG1131	(ABC) transporter
A4V09_RS01260	COG2207	Transcriptional regulator
A4V09_RS01265	COG5012	cobalamin binding
A4V09_RS01270	COG5598	trimethylamine methyltransferase
A4V09_RS01295	COG2738	Putative neutral zinc metallopeptidase
A4V09_RS01330	COG1609	Transcriptional regulator
A4V09_RS01340	COG1175	transmembrane transport
A4V09_RS01345	COG0395	ABC-type sugar transport system, permease component
A4V09_RS01365	COG1879	ABC-type sugar transport system periplasmic component
A4V09_RS01370	COG1129	ABC transporter
A4V09_RS01375	COG4211	Belongs to the binding-protein-dependent transport system permease family
A4V09_RS01380	COG4753	response regulator
A4V09_RS01380	COG2207	Transcriptional regulator
A4V09_RS01385	COG2972	Histidine kinase
A4V09_RS01405	COG1136	(ABC) transporter
A4V09_RS01420	COG1609	Transcriptional regulator
A4V09_RS01425	COG0673	inositol 2-dehydrogenase activity
A4V09_RS01440	COG1082	Xylose isomerase domain protein TIM barrel
A4V09_RS01445	COG1082	Xylose isomerase domain protein TIM barrel
A4V09_RS01460	COG1131	(ABC) transporter
A4V09_RS01495	COG1720	tRNA m6t6A37 methyltransferase activity
A4V09_RS01500	COG0367	asparagine synthase
A4V09_RS01505	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A4V09_RS01520	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
A4V09_RS01525	COG3708	Transcriptional regulator
A4V09_RS01525	COG2207	Transcriptional regulator
A4V09_RS01545	COG3250	beta-galactosidase activity
A4V09_RS01550	COG1874	Beta-galactosidase
A4V09_RS01560	COG1380	Effector of murein hydrolase LrgA
A4V09_RS01565	COG1346	cytolysis
A4V09_RS01585	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A4V09_RS01600	COG0357	Ribosomal RNA small subunit methyltransferase G
A4V09_RS01610	COG1175	transmembrane transport
A4V09_RS01615	COG0395	ABC-type sugar transport system, permease component
A4V09_RS01635	COG3959	Transketolase, thiamine diphosphate binding domain
A4V09_RS01640	COG3958	Transketolase
A4V09_RS01645	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A4V09_RS01670	COG1132	(ABC) transporter
A4V09_RS01675	COG1132	(ABC) transporter
A4V09_RS01680	COG2203	Gaf domain
A4V09_RS01680	COG3706	GGDEF domain
A4V09_RS01680	COG4251	negative regulation of phosphorylation
A4V09_RS01680	COG5001	Diguanylate cyclase
A4V09_RS01685	COG0582	viral genome integration into host DNA
A4V09_RS01705	COG0686	Belongs to the AlaDH PNT family
A4V09_RS01710	COG1115	amino acid carrier protein
A4V09_RS01715	COG4974	Belongs to the 'phage' integrase family
A4V09_RS01735	COG4536	flavin adenine dinucleotide binding
A4V09_RS01740	COG1408	metallophosphoesterase
A4V09_RS01750	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
A4V09_RS01760	COG1136	(ABC) transporter
A4V09_RS01770	COG0745	RESPONSE REGULATOR receiver
A4V09_RS01775	COG0642	Histidine kinase
A4V09_RS01780	COG1671	Belongs to the UPF0178 family
A4V09_RS01785	COG2205	protein histidine kinase activity
A4V09_RS01785	COG0784	Response regulator, receiver
A4V09_RS01785	COG5002	protein histidine kinase activity
A4V09_RS01795	COG2188	Transcriptional regulator
A4V09_RS01810	COG0110	maltose O-acetyltransferase activity
A4V09_RS01860	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
A4V09_RS01870	COG1268	BioY protein
A4V09_RS01875	COG0745	RESPONSE REGULATOR receiver
A4V09_RS01875	COG4566	intracellular signal transduction
A4V09_RS01910	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A4V09_RS01915	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A4V09_RS01920	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A4V09_RS01925	COG0151	Belongs to the GarS family
A4V09_RS01935	COG0110	maltose O-acetyltransferase activity
A4V09_RS01950	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
A4V09_RS01975	COG1086	Polysaccharide biosynthesis protein
A4V09_RS01985	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
A4V09_RS02000	COG3314	Sporulation integral membrane protein YlbJ
A4V09_RS02005	COG2986	histidine ammonia-lyase
A4V09_RS02015	COG2972	Histidine kinase
A4V09_RS02020	COG2207	Transcriptional regulator
A4V09_RS02020	COG4753	response regulator
A4V09_RS02025	COG1653	transport
A4V09_RS02030	COG1175	transmembrane transport
A4V09_RS02035	COG0395	ABC-type sugar transport system, permease component
A4V09_RS02065	COG0275	rRNA processing
A4V09_RS02070	COG0322	excinuclease ABC activity
A4V09_RS02075	COG3664	PFAM glycoside hydrolase family 39
A4V09_RS02080	COG2211	Major facilitator Superfamily
A4V09_RS02085	COG0673	inositol 2-dehydrogenase activity
A4V09_RS02110	COG0673	inositol 2-dehydrogenase activity
A4V09_RS02115	COG0110	maltose O-acetyltransferase activity
A4V09_RS02125	COG0366	Alpha amylase catalytic
A4V09_RS02135	COG1472	Belongs to the glycosyl hydrolase 3 family
A4V09_RS02150	COG4509	Sortase family
A4V09_RS02165	COG0360	Binds together with S18 to 16S ribosomal RNA
A4V09_RS02170	COG0629	single-stranded DNA binding
A4V09_RS02175	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A4V09_RS02190	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
A4V09_RS02195	COG0359	binds to the 23S rRNA
A4V09_RS02200	COG0305	Participates in initiation and elongation during chromosome replication
A4V09_RS02240	COG1459	type II secretion system
A4V09_RS02250	COG0322	excinuclease ABC activity
A4V09_RS02255	COG0745	RESPONSE REGULATOR receiver
A4V09_RS02260	COG5002	protein histidine kinase activity
A4V09_RS02280	COG0268	Binds directly to 16S ribosomal RNA
A4V09_RS02285	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
A4V09_RS02295	COG0481	GTPase activity
A4V09_RS02300	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A4V09_RS02320	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A4V09_RS02325	COG1040	competence protein
A4V09_RS02340	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
A4V09_RS02365	COG1376	ErfK ybiS ycfS ynhG family protein
A4V09_RS02370	COG0151	Belongs to the GarS family
A4V09_RS02380	COG0463	Glycosyl transferase, family 2
A4V09_RS02395	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A4V09_RS02410	COG1442	glycosyl transferase family 8
A4V09_RS02415	COG0562	UDP-galactopyranose mutase
A4V09_RS02420	COG3475	LICD family
A4V09_RS02450	COG1686	Belongs to the peptidase S11 family
A4V09_RS02455	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
A4V09_RS02460	COG1682	transport, permease protein
A4V09_RS02485	COG0438	transferase activity, transferring glycosyl groups
A4V09_RS02485	COG1216	Glycosyl transferase, family 2
A4V09_RS02500	COG1216	Glycosyl transferase, family 2
A4V09_RS02500	COG0438	transferase activity, transferring glycosyl groups
A4V09_RS02505	COG1216	Glycosyl transferase, family 2
A4V09_RS02515	COG0463	Glycosyl transferase, family 2
A4V09_RS02515	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A4V09_RS02520	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A4V09_RS02525	COG0463	Glycosyl transferase, family 2
A4V09_RS02530	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A4V09_RS02540	COG1134	teichoic acid transport
A4V09_RS02545	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A4V09_RS02590	COG1968	undecaprenyl-diphosphatase activity
A4V09_RS02595	COG0446	pyridine nucleotide-disulphide oxidoreductase
A4V09_RS02595	COG1902	pentaerythritol trinitrate reductase activity
A4V09_RS02615	COG0549	Belongs to the carbamate kinase family
A4V09_RS02620	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A4V09_RS02625	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A4V09_RS02645	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A4V09_RS02650	COG0631	protein serine/threonine phosphatase activity
A4V09_RS02655	COG0515	serine threonine protein kinase
A4V09_RS02655	COG2815	serine threonine protein kinase
A4V09_RS02665	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A4V09_RS02670	COG1564	THIamine pyrophosphokinase
A4V09_RS02675	COG0012	GTP binding
A4V09_RS02685	COG2001	Belongs to the MraZ family
A4V09_RS02700	COG0768	penicillin binding
A4V09_RS02705	COG0768	penicillin binding
A4V09_RS02715	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A4V09_RS02720	COG0772	Belongs to the SEDS family
A4V09_RS02725	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A4V09_RS02745	COG0521	Mo-molybdopterin cofactor biosynthetic process
A4V09_RS02760	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A4V09_RS02765	COG0710	3-dehydroquinate dehydratase activity
A4V09_RS02775	COG1191	sigma factor activity
A4V09_RS02780	COG1414	Transcriptional regulator
A4V09_RS02785	COG0800	Aldolase
A4V09_RS02795	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A4V09_RS02810	COG3534	alpha-L-arabinofuranosidase
A4V09_RS02815	COG1968	undecaprenyl-diphosphatase activity
A4V09_RS02825	COG1191	sigma factor activity
A4V09_RS02845	COG1363	Peptidase, m42
A4V09_RS02850	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
A4V09_RS02860	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A4V09_RS02875	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A4V09_RS02880	COG0444	Belongs to the ABC transporter superfamily
A4V09_RS02885	COG4608	Belongs to the ABC transporter superfamily
A4V09_RS02890	COG0436	Aminotransferase
A4V09_RS02895	COG0534	Mate efflux family protein
A4V09_RS02910	COG1132	(ABC) transporter
A4V09_RS02920	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
A4V09_RS02930	COG0640	Transcriptional regulator
A4V09_RS02935	COG0372	Belongs to the citrate synthase family
A4V09_RS02940	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
A4V09_RS02985	COG1187	pseudouridine synthase activity
A4V09_RS02990	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A4V09_RS02995	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A4V09_RS03000	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
A4V09_RS03015	COG1396	sequence-specific DNA binding
A4V09_RS03025	COG0464	growth
A4V09_RS03120	COG0511	ligase activity, forming carbon-carbon bonds
A4V09_RS03125	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A4V09_RS03130	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A4V09_RS03150	COG1846	Transcriptional regulator
A4V09_RS03165	COG0583	DNA-binding transcription factor activity
A4V09_RS03170	COG0019	diaminopimelate decarboxylase activity
A4V09_RS03175	COG0488	(ABC) transporter
A4V09_RS03180	COG1959	2 iron, 2 sulfur cluster binding
A4V09_RS03195	COG0584	glycerophosphoryl diester phosphodiesterase
A4V09_RS03215	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A4V09_RS03220	COG1381	Involved in DNA repair and RecF pathway recombination
A4V09_RS03225	COG0423	glycine-tRNA ligase activity
A4V09_RS03230	COG1609	Transcriptional regulator
A4V09_RS03235	COG1621	beta-fructofuranosidase activity
A4V09_RS03240	COG1653	transport
A4V09_RS03245	COG1175	transmembrane transport
A4V09_RS03250	COG0395	ABC-type sugar transport system, permease component
A4V09_RS03265	COG2972	Histidine kinase
A4V09_RS03275	COG1653	transport
A4V09_RS03280	COG1175	transmembrane transport
A4V09_RS03285	COG0395	ABC-type sugar transport system, permease component
A4V09_RS03290	COG2207	Transcriptional regulator
A4V09_RS03290	COG4753	response regulator
A4V09_RS03295	COG3681	Belongs to the UPF0597 family
A4V09_RS03305	COG4989	oxidoreductase activity
A4V09_RS03310	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A4V09_RS03310	COG0574	Belongs to the PEP-utilizing enzyme family
A4V09_RS03315	COG4977	sequence-specific DNA binding
A4V09_RS03315	COG1917	Cupin 2, conserved barrel domain protein
A4V09_RS03340	COG0688	phosphatidylethanolamine metabolic process
A4V09_RS03350	COG1285	pathogenesis
A4V09_RS03360	COG2378	regulation of single-species biofilm formation
A4V09_RS03370	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A4V09_RS03380	COG0513	Belongs to the DEAD box helicase family
A4V09_RS03385	COG1501	Belongs to the glycosyl hydrolase 31 family
A4V09_RS03395	COG0656	L-ascorbic acid biosynthetic process
A4V09_RS03400	COG1979	alcohol dehydrogenase
A4V09_RS03410	COG2032	superoxide dismutase activity
A4V09_RS03415	COG3546	catalase activity
A4V09_RS03425	COG1940	carbohydrate kinase activity
A4V09_RS03435	COG0613	PHP domain protein
A4V09_RS03445	COG2207	Transcriptional regulator
A4V09_RS03445	COG1917	Cupin 2, conserved barrel domain protein
A4V09_RS03465	COG2217	Heavy metal translocating P-type atpase
A4V09_RS03470	COG2186	Transcriptional regulator
A4V09_RS03480	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A4V09_RS03490	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
A4V09_RS03490	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
A4V09_RS03495	COG1063	alcohol dehydrogenase
A4V09_RS03500	COG1028	Short-chain dehydrogenase reductase Sdr
A4V09_RS03515	COG3546	catalase activity
A4V09_RS03530	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
A4V09_RS03545	COG0584	glycerophosphoryl diester phosphodiesterase
A4V09_RS03550	COG0772	Belongs to the SEDS family
A4V09_RS03555	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A4V09_RS03560	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A4V09_RS03570	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A4V09_RS03575	COG0511	ligase activity, forming carbon-carbon bonds
A4V09_RS03580	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A4V09_RS03585	COG0439	Biotin carboxylase
A4V09_RS03595	COG2070	2-Nitropropane dioxygenase
A4V09_RS03615	COG4753	response regulator
A4V09_RS03615	COG2207	Transcriptional regulator
A4V09_RS03620	COG2972	Histidine kinase
A4V09_RS03625	COG1175	transmembrane transport
A4V09_RS03630	COG0395	ABC-type sugar transport system, permease component
A4V09_RS03635	COG1501	Belongs to the glycosyl hydrolase 31 family
A4V09_RS03650	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A4V09_RS03655	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
A4V09_RS03660	COG2080	2 iron, 2 sulfur cluster binding
A4V09_RS03675	COG1653	transport
A4V09_RS03685	COG0395	ABC-type sugar transport system, permease component
A4V09_RS03700	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A4V09_RS03705	COG0210	DNA helicase
A4V09_RS03715	COG0667	Aldo Keto reductase
A4V09_RS03720	COG4978	Transcriptional regulator
A4V09_RS03720	COG0789	Transcriptional regulator
A4V09_RS03730	COG1609	Transcriptional regulator
A4V09_RS03730	COG2207	Transcriptional regulator
A4V09_RS03745	COG3854	ATPases associated with a variety of cellular activities
A4V09_RS03785	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
A4V09_RS03795	COG1302	Protein conserved in bacteria
A4V09_RS03805	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A4V09_RS03810	COG1570	exodeoxyribonuclease VII activity
A4V09_RS03815	COG1722	exodeoxyribonuclease VII activity
A4V09_RS03825	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A4V09_RS03830	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
A4V09_RS03835	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A4V09_RS03840	COG1438	arginine binding
A4V09_RS03845	COG0497	DNA recombination
A4V09_RS03850	COG0750	zinc metalloprotease
A4V09_RS03855	COG0745	RESPONSE REGULATOR receiver
A4V09_RS03860	COG0297	glycogen (starch) synthase activity
A4V09_RS03870	COG0745	RESPONSE REGULATOR receiver
A4V09_RS03875	COG5002	protein histidine kinase activity
A4V09_RS03885	COG1136	(ABC) transporter
A4V09_RS03905	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
A4V09_RS03915	COG1418	mRNA catabolic process
A4V09_RS03930	COG4974	Belongs to the 'phage' integrase family
A4V09_RS03935	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A4V09_RS03955	COG2244	polysaccharide biosynthetic process
A4V09_RS03960	COG1959	2 iron, 2 sulfur cluster binding
A4V09_RS03970	COG0822	iron-sulfur transferase activity
A4V09_RS03975	COG0482	sulfurtransferase activity
A4V09_RS03980	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
A4V09_RS03995	COG0149	triose-phosphate isomerase activity
A4V09_RS04010	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4V09_RS04015	COG0765	amino acid transport
A4V09_RS04020	COG1126	abc transporter atp-binding protein
A4V09_RS04025	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
A4V09_RS04030	COG4977	sequence-specific DNA binding
A4V09_RS04065	COG0148	phosphopyruvate hydratase activity
A4V09_RS04070	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A4V09_RS04075	COG0557	exoribonuclease II activity
A4V09_RS04080	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
A4V09_RS04105	COG2205	protein histidine kinase activity
A4V09_RS04130	COG0745	RESPONSE REGULATOR receiver
A4V09_RS04135	COG5002	protein histidine kinase activity
A4V09_RS04155	COG0343	queuine tRNA-ribosyltransferase activity
A4V09_RS04170	COG1760	l-serine dehydratase
A4V09_RS04175	COG2207	Transcriptional regulator
A4V09_RS04175	COG3708	Transcriptional regulator
A4V09_RS04185	COG1476	TRANSCRIPTIONal
A4V09_RS04215	COG0129	dihydroxy-acid dehydratase activity
A4V09_RS04220	COG0028	Belongs to the TPP enzyme family
A4V09_RS04225	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
A4V09_RS04230	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A4V09_RS04240	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A4V09_RS04250	COG1160	GTP binding
A4V09_RS04255	COG0456	acetyltransferase
A4V09_RS04285	COG0517	IMP dehydrogenase activity
A4V09_RS04285	COG0516	GMP reductase activity
A4V09_RS04290	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
A4V09_RS04295	COG0668	transmembrane transport
A4V09_RS04320	COG1793	dna ligase
A4V09_RS04325	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
A4V09_RS04335	COG3842	ATPase activity
A4V09_RS04340	COG1176	ABC-type spermidine putrescine transport system, permease component I
A4V09_RS04345	COG1177	transmembrane transport
A4V09_RS04370	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A4V09_RS04375	COG3279	Response regulator of the LytR AlgR family
A4V09_RS04400	COG1136	(ABC) transporter
A4V09_RS04410	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A4V09_RS04425	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A4V09_RS04430	COG1116	anion transmembrane transporter activity
A4V09_RS04435	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A4V09_RS04440	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A4V09_RS04445	COG0165	Argininosuccinate lyase
A4V09_RS04460	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A4V09_RS04505	COG0438	transferase activity, transferring glycosyl groups
A4V09_RS04510	COG0438	transferase activity, transferring glycosyl groups
A4V09_RS04515	COG0398	Pfam SNARE associated Golgi protein
A4V09_RS04545	COG3383	formate dehydrogenase (NAD+) activity
A4V09_RS04555	COG0746	molybdenum cofactor guanylyltransferase activity
A4V09_RS04595	COG2188	Transcriptional regulator
A4V09_RS04600	COG1131	(ABC) transporter
A4V09_RS04610	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
A4V09_RS04630	COG2378	regulation of single-species biofilm formation
A4V09_RS04635	COG3340	Belongs to the peptidase S51 family
A4V09_RS04660	COG0534	Mate efflux family protein
A4V09_RS04670	COG1230	cation diffusion facilitator family transporter
A4V09_RS04680	COG2198	Histidine kinase
A4V09_RS04680	COG0784	Response regulator, receiver
A4V09_RS04680	COG2205	protein histidine kinase activity
A4V09_RS04695	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A4V09_RS04700	COG3022	response to hydroperoxide
A4V09_RS04705	COG0534	Mate efflux family protein
A4V09_RS04715	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
A4V09_RS04725	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A4V09_RS04735	COG0733	neurotransmitter:sodium symporter activity
A4V09_RS04745	COG0528	UMP kinase activity
A4V09_RS04750	COG0233	cytoplasmic translational termination
A4V09_RS04755	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A4V09_RS04760	COG4589	Belongs to the CDS family
A4V09_RS04770	COG0750	zinc metalloprotease
A4V09_RS04785	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A4V09_RS04785	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A4V09_RS04790	COG3158	transport of potassium into the cell
A4V09_RS04815	COG3279	Response regulator of the LytR AlgR family
A4V09_RS04855	COG1131	(ABC) transporter
A4V09_RS04885	COG4977	sequence-specific DNA binding
A4V09_RS04895	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
A4V09_RS04900	COG0232	Belongs to the dGTPase family. Type 2 subfamily
A4V09_RS04905	COG0358	DNA primase activity
A4V09_RS04910	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A4V09_RS04940	COG1605	Chorismate mutase
A4V09_RS04940	COG0077	Prephenate dehydratase
A4V09_RS04950	COG0540	Belongs to the ATCase OTCase family
A4V09_RS04965	COG0534	Mate efflux family protein
A4V09_RS04985	COG0697	spore germination
A4V09_RS05000	COG0725	ABC transporter, periplasmic molybdate-binding protein
A4V09_RS05005	COG4149	molybdate abc transporter
A4V09_RS05015	COG1522	sequence-specific DNA binding
A4V09_RS05020	COG0436	Aminotransferase
A4V09_RS05030	COG0527	aspartate kinase activity
A4V09_RS05040	COG0824	Thioesterase
A4V09_RS05045	COG1725	Transcriptional regulator
A4V09_RS05075	COG1607	acyl-coa hydrolase
A4V09_RS05085	COG0237	dephospho-CoA kinase activity
A4V09_RS05090	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A4V09_RS05100	COG2848	UPF0210 protein
A4V09_RS05115	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
A4V09_RS05115	COG1918	ferrous iron import across plasma membrane
A4V09_RS05140	COG0333	Belongs to the bacterial ribosomal protein bL32 family
A4V09_RS05150	COG0416	fatty acid biosynthetic process
A4V09_RS05155	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A4V09_RS05160	COG0571	ribonuclease III activity
A4V09_RS05165	COG1196	nuclear chromosome segregation
A4V09_RS05170	COG0552	protein localization to endoplasmic reticulum
A4V09_RS05175	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A4V09_RS05185	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
A4V09_RS05190	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
A4V09_RS05195	COG1606	tRNA processing
A4V09_RS05235	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A4V09_RS05245	COG1837	Belongs to the UPF0109 family
A4V09_RS05250	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A4V09_RS05255	COG0336	Belongs to the RNA methyltransferase TrmD family
A4V09_RS05270	COG0438	transferase activity, transferring glycosyl groups
A4V09_RS05285	COG0438	transferase activity, transferring glycosyl groups
A4V09_RS05295	COG0535	radical SAM domain protein
A4V09_RS05305	COG0110	maltose O-acetyltransferase activity
A4V09_RS05315	COG1216	Glycosyl transferase, family 2
A4V09_RS05375	COG4464	protein tyrosine phosphatase activity
A4V09_RS05390	COG4509	Sortase family
A4V09_RS05395	COG1316	TRANSCRIPTIONal
A4V09_RS05410	COG4978	Transcriptional regulator
A4V09_RS05410	COG0789	Transcriptional regulator
A4V09_RS05415	COG1091	dTDP-4-dehydrorhamnose reductase activity
A4V09_RS05430	COG0335	large ribosomal subunit rRNA binding
A4V09_RS05435	COG0681	Belongs to the peptidase S26 family
A4V09_RS05445	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A4V09_RS05450	COG0792	nuclease activity
A4V09_RS05455	COG1496	oxidoreductase activity
A4V09_RS05465	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A4V09_RS05475	COG1160	GTP binding
A4V09_RS05485	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A4V09_RS05490	COG1136	(ABC) transporter
A4V09_RS05490	COG0577	efflux transmembrane transporter activity
A4V09_RS05500	COG0577	efflux transmembrane transporter activity
A4V09_RS05500	COG1136	(ABC) transporter
A4V09_RS05505	COG0656	L-ascorbic acid biosynthetic process
A4V09_RS05510	COG0420	3'-5' exonuclease activity
A4V09_RS05515	COG0419	ATPase involved in DNA repair
A4V09_RS05530	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
A4V09_RS05540	COG1151	hydroxylamine reductase activity
A4V09_RS05585	COG3404	Formiminotransferase-cyclodeaminase
A4V09_RS05590	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A4V09_RS05605	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
A4V09_RS05615	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
A4V09_RS05660	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
A4V09_RS05680	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A4V09_RS05715	COG0310	cobalt ion transport
A4V09_RS05720	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
A4V09_RS05735	COG0113	porphobilinogen synthase activity
A4V09_RS05740	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
A4V09_RS05745	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A4V09_RS05750	COG0328	RNA-DNA hybrid ribonuclease activity
A4V09_RS05765	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A4V09_RS05770	COG0828	Belongs to the bacterial ribosomal protein bS21 family
A4V09_RS05775	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A4V09_RS05790	COG1686	Belongs to the peptidase S11 family
A4V09_RS05795	COG0534	Mate efflux family protein
A4V09_RS05800	COG1408	metallophosphoesterase
A4V09_RS05805	COG0714	Associated with various cellular activities
A4V09_RS05820	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
A4V09_RS05825	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
A4V09_RS05835	COG2270	Major facilitator Superfamily
A4V09_RS05840	COG1686	Belongs to the peptidase S11 family
A4V09_RS05855	COG0071	Belongs to the small heat shock protein (HSP20) family
A4V09_RS05870	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A4V09_RS05875	COG2084	Dehydrogenase
A4V09_RS05890	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A4V09_RS05895	COG1115	amino acid carrier protein
A4V09_RS05910	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A4V09_RS05935	COG0512	Glutamine amidotransferase of anthranilate synthase
A4V09_RS05935	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A4V09_RS05940	COG0134	indole-3-glycerol-phosphate synthase activity
A4V09_RS05945	COG0135	phosphoribosylanthranilate isomerase activity
A4V09_RS05955	COG0159	tryptophan synthase activity
A4V09_RS05960	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A4V09_RS05970	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
A4V09_RS05975	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
A4V09_RS05985	COG1737	Transcriptional regulator
A4V09_RS05990	COG2081	HI0933 family
A4V09_RS06000	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
A4V09_RS06005	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
A4V09_RS06005	COG0539	negative regulation of cytoplasmic translation
A4V09_RS06020	COG4656	Part of a membrane complex involved in electron transport
A4V09_RS06025	COG4658	electron transport chain
A4V09_RS06035	COG4660	Part of a membrane complex involved in electron transport
A4V09_RS06040	COG4657	Part of a membrane complex involved in electron transport
A4V09_RS06045	COG2878	Part of a membrane complex involved in electron transport
A4V09_RS06045	COG1245	4Fe-4S binding domain
A4V09_RS06065	COG0632	four-way junction helicase activity
A4V09_RS06070	COG2255	four-way junction helicase activity
A4V09_RS06080	COG0826	peptidase U32
A4V09_RS06090	COG0768	penicillin binding
A4V09_RS06095	COG1051	belongs to the nudix hydrolase family
A4V09_RS06120	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A4V09_RS06130	COG1461	Dihydroxyacetone kinase
A4V09_RS06135	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A4V09_RS06155	COG1803	Methylglyoxal synthase
A4V09_RS06160	COG0742	ribosomal rna small subunit methyltransferase
A4V09_RS06165	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
A4V09_RS06175	COG3314	Sporulation integral membrane protein YlbJ
A4V09_RS06185	COG2195	Cleaves the N-terminal amino acid of tripeptides
A4V09_RS06190	COG0739	heme binding
A4V09_RS06195	COG2357	RelA SpoT domain protein
A4V09_RS06200	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
A4V09_RS06200	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A4V09_RS06205	COG1187	pseudouridine synthase activity
A4V09_RS06210	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A4V09_RS06220	COG4221	oxidoreductase activity
A4V09_RS06230	COG0564	pseudouridine synthase activity
A4V09_RS06235	COG0681	Belongs to the peptidase S26 family
A4V09_RS06240	COG3331	DNA recombination
A4V09_RS06245	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
A4V09_RS06260	COG0745	RESPONSE REGULATOR receiver
A4V09_RS06265	COG2205	protein histidine kinase activity
A4V09_RS06270	COG1136	(ABC) transporter
A4V09_RS06275	COG0577	efflux transmembrane transporter activity
A4V09_RS06305	COG4819	ethanolamine utilization protein
A4V09_RS06310	COG4303	Ethanolamine ammonia lyase large subunit
A4V09_RS06315	COG4302	ethanolamine ammonia-lyase activity
A4V09_RS06320	COG4816	utilization protein
A4V09_RS06325	COG1012	belongs to the aldehyde dehydrogenase family
A4V09_RS06325	COG1454	alcohol dehydrogenase
A4V09_RS06340	COG4869	propanediol catabolic process
A4V09_RS06350	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
A4V09_RS06355	COG3192	ethanolamine utilization protein
A4V09_RS06365	COG0719	Fe-S assembly protein
A4V09_RS06390	COG2207	Transcriptional regulator
A4V09_RS06415	COG0534	Mate efflux family protein
A4V09_RS06420	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A4V09_RS06425	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A4V09_RS06460	COG0789	Transcriptional regulator
A4V09_RS06465	COG1131	(ABC) transporter
A4V09_RS06475	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A4V09_RS06505	COG4656	Part of a membrane complex involved in electron transport
A4V09_RS06515	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
A4V09_RS06515	COG0646	methionine synthase
A4V09_RS06540	COG1530	ribonuclease E activity
A4V09_RS06545	COG1051	belongs to the nudix hydrolase family
A4V09_RS06565	COG0211	Belongs to the bacterial ribosomal protein bL27 family
A4V09_RS06570	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A4V09_RS06575	COG1534	Rna-binding protein
A4V09_RS06580	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
A4V09_RS06585	COG1713	HD superfamily hydrolase involved in NAD metabolism
A4V09_RS06590	COG0799	negative regulation of ribosome biogenesis
A4V09_RS06595	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A4V09_RS06605	COG1609	Transcriptional regulator
A4V09_RS06620	COG0371	Dehydrogenase
A4V09_RS06640	COG1131	(ABC) transporter
A4V09_RS06675	COG1686	Belongs to the peptidase S11 family
A4V09_RS06680	COG0488	(ABC) transporter
A4V09_RS06695	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A4V09_RS06700	COG0583	DNA-binding transcription factor activity
A4V09_RS06710	COG2059	Chromate
A4V09_RS06720	COG0745	RESPONSE REGULATOR receiver
A4V09_RS06725	COG5002	protein histidine kinase activity
A4V09_RS06730	COG1136	(ABC) transporter
A4V09_RS06735	COG0577	efflux transmembrane transporter activity
A4V09_RS06750	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
A4V09_RS06765	COG2207	Transcriptional regulator
A4V09_RS06765	COG1917	Cupin 2, conserved barrel domain protein
A4V09_RS06770	COG0697	spore germination
A4V09_RS06800	COG2945	thiolester hydrolase activity
A4V09_RS06800	COG0596	Alpha beta hydrolase
A4V09_RS06805	COG0583	DNA-binding transcription factor activity
A4V09_RS06810	COG0745	RESPONSE REGULATOR receiver
A4V09_RS06815	COG5002	protein histidine kinase activity
A4V09_RS06825	COG1201	RNA secondary structure unwinding
A4V09_RS06835	COG0534	Mate efflux family protein
A4V09_RS06845	COG1136	(ABC) transporter
A4V09_RS06845	COG0577	efflux transmembrane transporter activity
A4V09_RS06860	COG0745	RESPONSE REGULATOR receiver
A4V09_RS06880	COG1490	D-aminoacyl-tRNA deacylase activity
A4V09_RS06885	COG0628	permease
A4V09_RS06890	COG0037	tRNA processing
A4V09_RS06905	COG0564	pseudouridine synthase activity
A4V09_RS06915	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A4V09_RS06920	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A4V09_RS06930	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A4V09_RS06940	COG2155	Conserved Protein
A4V09_RS06950	COG1686	Belongs to the peptidase S11 family
A4V09_RS06955	COG1803	Methylglyoxal synthase
A4V09_RS06965	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
A4V09_RS06970	COG2894	cell division
A4V09_RS06975	COG0768	penicillin binding
A4V09_RS06995	COG2003	Belongs to the UPF0758 family
A4V09_RS07000	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
A4V09_RS07005	COG2081	HI0933 family
A4V09_RS07010	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
A4V09_RS07015	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A4V09_RS07025	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A4V09_RS07030	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A4V09_RS07035	COG4224	UPF0291 protein
A4V09_RS07040	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A4V09_RS07065	COG1702	phosphate starvation-inducible protein PhoH
A4V09_RS07070	COG2176	DNA-directed DNA polymerase activity
A4V09_RS07090	COG0596	Alpha beta hydrolase
A4V09_RS07095	COG3453	Protein conserved in bacteria
A4V09_RS07095	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A4V09_RS07105	COG1136	(ABC) transporter
A4V09_RS07135	COG0745	RESPONSE REGULATOR receiver
A4V09_RS07145	COG1136	(ABC) transporter
A4V09_RS07150	COG5293	efflux transmembrane transporter activity
A4V09_RS07160	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
A4V09_RS07185	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A4V09_RS07185	COG1199	ATP-dependent helicase activity
A4V09_RS07205	COG5002	protein histidine kinase activity
A4V09_RS07205	COG0642	Histidine kinase
A4V09_RS07210	COG0745	RESPONSE REGULATOR receiver
A4V09_RS07215	COG0688	phosphatidylethanolamine metabolic process
A4V09_RS07220	COG1183	phosphatidylcholine synthase activity
A4V09_RS07235	COG1696	Membrane protein involved in D-alanine export
A4V09_RS07250	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A4V09_RS07270	COG0454	-acetyltransferase
A4V09_RS07285	COG3344	reverse transcriptase
A4V09_RS07365	COG3344	reverse transcriptase
A4V09_RS07425	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A4V09_RS07430	COG4509	Sortase family
A4V09_RS07450	COG0270	DNA (cytosine-5-)-methyltransferase activity
A4V09_RS07495	COG1136	(ABC) transporter
A4V09_RS07500	COG5002	protein histidine kinase activity
A4V09_RS07505	COG0745	RESPONSE REGULATOR receiver
A4V09_RS07530	COG3250	beta-galactosidase activity
A4V09_RS07535	COG2211	Major facilitator Superfamily
A4V09_RS07570	COG3706	GGDEF domain
A4V09_RS07595	COG0745	RESPONSE REGULATOR receiver
A4V09_RS07600	COG5002	protein histidine kinase activity
A4V09_RS07615	COG0583	DNA-binding transcription factor activity
A4V09_RS07625	COG1482	cell wall glycoprotein biosynthetic process
A4V09_RS07630	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A4V09_RS07645	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
A4V09_RS07650	COG2942	2-epimerase
A4V09_RS07655	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
A4V09_RS07660	COG0395	ABC-type sugar transport system, permease component
A4V09_RS07665	COG1175	transmembrane transport
A4V09_RS07670	COG2182	Extracellular solute-binding protein
A4V09_RS07675	COG1609	Transcriptional regulator
A4V09_RS07725	COG2176	DNA-directed DNA polymerase activity
A4V09_RS07775	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A4V09_RS07795	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
A4V09_RS07820	COG1674	ftsk spoiiie
A4V09_RS07825	COG1968	undecaprenyl-diphosphatase activity
A4V09_RS07830	COG0740	serine-type endopeptidase activity
A4V09_RS07835	COG0217	transcriptional regulatory protein
A4V09_RS07840	COG1253	flavin adenine dinucleotide binding
A4V09_RS07845	COG3344	reverse transcriptase
A4V09_RS07860	COG2337	Toxic component of a toxin-antitoxin (TA) module
A4V09_RS07865	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A4V09_RS07870	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
A4V09_RS07870	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A4V09_RS07875	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
A4V09_RS07880	COG0488	(ABC) transporter
A4V09_RS07890	COG1131	(ABC) transporter
A4V09_RS07905	COG1802	Transcriptional regulator
A4V09_RS07910	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A4V09_RS07915	COG1404	Belongs to the peptidase S8 family
A4V09_RS07940	COG1546	Belongs to the CinA family
A4V09_RS07940	COG1058	Belongs to the CinA family
A4V09_RS07945	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A4V09_RS07950	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A4V09_RS07955	COG1758	RNA polymerase activity
A4V09_RS07960	COG0194	GDP metabolic process
A4V09_RS07965	COG2052	Domain of unknown function (DUF370)
A4V09_RS07970	COG1561	YicC-like family, N-terminal region
A4V09_RS07975	COG1293	RNA-binding protein homologous to eukaryotic snRNP
A4V09_RS07990	COG2198	Histidine kinase
A4V09_RS07990	COG0643	Histidine kinase
A4V09_RS08000	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
A4V09_RS08005	COG1776	CheC inhibitor of MCP methylation
A4V09_RS08015	COG2201	protein-glutamate methylesterase activity
A4V09_RS08035	COG0495	leucyl-tRNA aminoacylation
A4V09_RS08045	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A4V09_RS08050	COG0287	Prephenate dehydrogenase
A4V09_RS08065	COG4716	Myosin-crossreactive antigen
A4V09_RS08070	COG2986	histidine ammonia-lyase
A4V09_RS08085	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A4V09_RS08100	COG0784	Response regulator, receiver
A4V09_RS08100	COG2205	protein histidine kinase activity
A4V09_RS08120	COG5001	Diguanylate cyclase
A4V09_RS08120	COG3300	MHYT domain
A4V09_RS08145	COG1773	rubredoxin
A4V09_RS08145	COG0426	domain, Protein
A4V09_RS08235	COG3290	protein histidine kinase activity
A4V09_RS08330	COG1131	(ABC) transporter
A4V09_RS08345	COG0577	efflux transmembrane transporter activity
A4V09_RS08345	COG1136	(ABC) transporter
A4V09_RS08350	COG0577	efflux transmembrane transporter activity
A4V09_RS08350	COG1136	(ABC) transporter
A4V09_RS08415	COG0175	sulfate reduction
A4V09_RS08475	COG0745	RESPONSE REGULATOR receiver
A4V09_RS08480	COG2205	protein histidine kinase activity
A4V09_RS08480	COG0784	Response regulator, receiver
A4V09_RS08485	COG2205	protein histidine kinase activity
A4V09_RS08495	COG2188	Transcriptional regulator
A4V09_RS08500	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
A4V09_RS08505	COG0406	alpha-ribazole phosphatase activity
A4V09_RS08510	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A4V09_RS08510	COG0072	phenylalanine-tRNA ligase activity
A4V09_RS08515	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
A4V09_RS08525	COG2385	sporulation resulting in formation of a cellular spore
A4V09_RS08525	COG2247	cell wall binding repeat
A4V09_RS08555	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
A4V09_RS08565	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A4V09_RS08595	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
A4V09_RS08630	COG0066	3-isopropylmalate dehydratase activity
A4V09_RS08635	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A4V09_RS08640	COG0583	DNA-binding transcription factor activity
A4V09_RS08645	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
A4V09_RS08650	COG0440	acetolactate synthase activity
A4V09_RS08680	COG0747	negative chemotaxis
A4V09_RS08685	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A4V09_RS08690	COG0601	transmembrane transport
A4V09_RS08700	COG0583	DNA-binding transcription factor activity
A4V09_RS08710	COG3620	sequence-specific DNA binding
A4V09_RS08720	COG1131	(ABC) transporter
A4V09_RS08775	COG1475	DNA binding
A4V09_RS08780	COG3969	phosphoadenosine phosphosulfate
A4V09_RS08795	COG0546	phosphoglycolate phosphatase activity
A4V09_RS08810	COG3842	ATPase activity
A4V09_RS08815	COG0395	ABC-type sugar transport system, permease component
A4V09_RS08820	COG4209	transmembrane transport
A4V09_RS08870	COG5002	protein histidine kinase activity
A4V09_RS08875	COG0745	RESPONSE REGULATOR receiver
A4V09_RS08890	COG1131	(ABC) transporter
A4V09_RS08900	COG5504	Zn-dependent protease
A4V09_RS08905	COG0789	Transcriptional regulator
A4V09_RS08910	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A4V09_RS08930	COG3250	beta-galactosidase activity
A4V09_RS08935	COG0355	proton-transporting ATP synthase activity, rotational mechanism
A4V09_RS08940	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
A4V09_RS08945	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A4V09_RS08950	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
A4V09_RS08970	COG0356	it plays a direct role in the translocation of protons across the membrane
A4V09_RS08985	COG3118	belongs to the thioredoxin family
A4V09_RS08990	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A4V09_RS08995	COG2211	Major facilitator Superfamily
A4V09_RS09000	COG2272	Belongs to the type-B carboxylesterase lipase family
A4V09_RS09010	COG1917	Cupin 2, conserved barrel domain protein
A4V09_RS09010	COG4977	sequence-specific DNA binding
A4V09_RS09015	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A4V09_RS09055	COG0745	RESPONSE REGULATOR receiver
A4V09_RS09060	COG0745	RESPONSE REGULATOR receiver
A4V09_RS09075	COG1131	(ABC) transporter
A4V09_RS09080	COG3850	Histidine kinase
A4V09_RS09080	COG5002	protein histidine kinase activity
A4V09_RS09115	COG4555	ABC transporter
A4V09_RS09175	COG0583	DNA-binding transcription factor activity
A4V09_RS09180	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A4V09_RS09185	COG1278	Cold shock
A4V09_RS09200	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A4V09_RS09205	COG1882	Formate acetyltransferase
A4V09_RS09210	COG0351	phosphomethylpyrimidine kinase
A4V09_RS09210	COG0352	thiamine-phosphate diphosphorylase activity
A4V09_RS09215	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A4V09_RS09235	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A4V09_RS09240	COG1393	Belongs to the ArsC family
A4V09_RS09250	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A4V09_RS09255	COG2508	Transcriptional regulator
A4V09_RS09275	COG2162	N-hydroxyarylamine O-acetyltransferase activity
A4V09_RS09290	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A4V09_RS09305	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A4V09_RS09335	COG1132	(ABC) transporter
A4V09_RS09340	COG1132	(ABC) transporter
A4V09_RS09350	COG0583	DNA-binding transcription factor activity
A4V09_RS09360	COG0564	pseudouridine synthase activity
A4V09_RS09370	COG5001	Diguanylate cyclase
A4V09_RS09395	COG2819	hydrolase of the alpha beta superfamily
A4V09_RS09410	COG3588	fructose-bisphosphate aldolase
A4V09_RS09415	COG1027	Aspartate ammonia-lyase
A4V09_RS09420	COG0583	DNA-binding transcription factor activity
A4V09_RS09455	COG2207	Transcriptional regulator
A4V09_RS09475	COG1131	(ABC) transporter
A4V09_RS09520	COG0534	Mate efflux family protein
A4V09_RS09565	COG0789	Transcriptional regulator
A4V09_RS09575	COG1595	DNA-templated transcription, initiation
A4V09_RS09635	COG1278	Cold shock
A4V09_RS09645	COG3507	Belongs to the glycosyl hydrolase 43 family
A4V09_RS09675	COG1032	radical SAM domain protein
A4V09_RS09695	COG2274	protein secretion by the type I secretion system
A4V09_RS09700	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A4V09_RS09710	COG1131	(ABC) transporter
A4V09_RS09720	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A4V09_RS09730	COG1131	(ABC) transporter
A4V09_RS09775	COG4129	membrane
A4V09_RS09805	COG1733	regulation of RNA biosynthetic process
A4V09_RS09820	COG4974	Belongs to the 'phage' integrase family
A4V09_RS09830	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
A4V09_RS09850	COG1733	regulation of RNA biosynthetic process
A4V09_RS09870	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
A4V09_RS09875	COG0052	Belongs to the universal ribosomal protein uS2 family
A4V09_RS09895	COG0515	serine threonine protein kinase
A4V09_RS09905	COG1307	EDD domain protein, DegV family
A4V09_RS09915	COG0577	efflux transmembrane transporter activity
A4V09_RS09930	COG0745	RESPONSE REGULATOR receiver
A4V09_RS09935	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A4V09_RS09940	COG0395	ABC-type sugar transport system, permease component
A4V09_RS09945	COG1175	transmembrane transport
A4V09_RS09970	COG1609	Transcriptional regulator
A4V09_RS09985	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
A4V09_RS09990	COG0124	histidyl-tRNA synthetase
A4V09_RS10000	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A4V09_RS10005	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A4V09_RS10010	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A4V09_RS10025	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
A4V09_RS10025	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A4V09_RS10030	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A4V09_RS10030	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A4V09_RS10055	COG4536	flavin adenine dinucleotide binding
A4V09_RS10070	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
A4V09_RS10075	COG3250	beta-galactosidase activity
A4V09_RS10080	COG2388	GCN5-related N-acetyl-transferase
A4V09_RS10085	COG0534	Mate efflux family protein
A4V09_RS10105	COG2816	NAD+ diphosphatase activity
A4V09_RS10110	COG1136	(ABC) transporter
A4V09_RS10140	COG4106	trans-aconitate 2-methyltransferase activity
A4V09_RS10145	COG1012	belongs to the aldehyde dehydrogenase family
A4V09_RS10155	COG0561	phosphatase activity
A4V09_RS10160	COG0546	phosphoglycolate phosphatase activity
A4V09_RS10170	COG0561	phosphatase activity
A4V09_RS10180	COG1116	anion transmembrane transporter activity
A4V09_RS10185	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A4V09_RS10190	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A4V09_RS10200	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A4V09_RS10205	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A4V09_RS10210	COG0493	'glutamate synthase
A4V09_RS10210	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
A4V09_RS10215	COG0402	S-adenosylhomocysteine deaminase activity
A4V09_RS10225	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A4V09_RS10235	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
A4V09_RS10240	COG0534	Mate efflux family protein
A4V09_RS10250	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A4V09_RS10260	COG0295	cytidine deaminase activity
A4V09_RS10265	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
A4V09_RS10275	COG3250	beta-galactosidase activity
A4V09_RS10280	COG0395	ABC-type sugar transport system, permease component
A4V09_RS10285	COG1175	transmembrane transport
A4V09_RS10290	COG1653	transport
A4V09_RS10300	COG1115	amino acid carrier protein
A4V09_RS10315	COG0205	6-phosphofructokinase activity
A4V09_RS10325	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A4V09_RS10330	COG4608	Belongs to the ABC transporter superfamily
A4V09_RS10335	COG0444	Belongs to the ABC transporter superfamily
A4V09_RS10340	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A4V09_RS10345	COG0601	transmembrane transport
A4V09_RS10350	COG0747	negative chemotaxis
A4V09_RS10375	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A4V09_RS10380	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A4V09_RS10385	COG1733	regulation of RNA biosynthetic process
A4V09_RS10395	COG0488	(ABC) transporter
A4V09_RS10400	COG1735	metal-dependent hydrolase with the TIM-barrel fold
A4V09_RS10405	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A4V09_RS10410	COG0460	homoserine dehydrogenase
A4V09_RS10485	COG3052	prosthetic group binding
A4V09_RS10490	COG3404	Formiminotransferase-cyclodeaminase
A4V09_RS10500	COG1228	amidohydrolase
A4V09_RS10515	COG0492	ferredoxin-NADP+ reductase activity
A4V09_RS10525	COG2378	regulation of single-species biofilm formation
A4V09_RS10530	COG0693	protein deglycase activity
A4V09_RS10550	COG2986	histidine ammonia-lyase
A4V09_RS10555	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
A4V09_RS10585	COG2986	histidine ammonia-lyase
A4V09_RS10605	COG5598	trimethylamine methyltransferase
A4V09_RS10610	COG0251	oxidation-reduction process
A4V09_RS10625	COG1115	amino acid carrier protein
A4V09_RS10640	COG0488	(ABC) transporter
A4V09_RS10645	COG1131	(ABC) transporter
A4V09_RS10660	COG0745	RESPONSE REGULATOR receiver
A4V09_RS10665	COG2205	protein histidine kinase activity
A4V09_RS10675	COG1175	transmembrane transport
A4V09_RS10680	COG1653	transport
A4V09_RS10685	COG2207	Transcriptional regulator
A4V09_RS10690	COG0242	peptide deformylase activity
A4V09_RS10720	COG2986	histidine ammonia-lyase
A4V09_RS10745	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
A4V09_RS10745	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
A4V09_RS10760	COG1247	-acetyltransferase
A4V09_RS10780	COG0577	efflux transmembrane transporter activity
A4V09_RS10805	COG1757	Na H antiporter
A4V09_RS10815	COG0251	oxidation-reduction process
A4V09_RS10820	COG2964	Protein conserved in bacteria
A4V09_RS10840	COG4399	Belongs to the UPF0754 family
A4V09_RS10845	COG3681	Belongs to the UPF0597 family
A4V09_RS10855	COG0484	heat shock protein binding
A4V09_RS10865	COG2357	RelA SpoT domain protein
A4V09_RS10875	COG0534	Mate efflux family protein
A4V09_RS10885	COG1803	Methylglyoxal synthase
A4V09_RS10890	COG1597	lipid kinase activity
A4V09_RS10895	COG0584	glycerophosphoryl diester phosphodiesterase
A4V09_RS10910	COG0745	RESPONSE REGULATOR receiver
A4V09_RS10915	COG0534	Mate efflux family protein
A4V09_RS10920	COG1979	alcohol dehydrogenase
A4V09_RS10965	COG0583	DNA-binding transcription factor activity
A4V09_RS10970	COG1216	Glycosyl transferase, family 2
A4V09_RS10975	COG1194	a g-specific adenine glycosylase
A4V09_RS10985	COG0647	UMP catabolic process
A4V09_RS11005	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
A4V09_RS11055	COG1473	amidohydrolase
A4V09_RS11060	COG1288	antiporter activity
A4V09_RS11085	COG0739	heme binding
A4V09_RS11085	COG0741	lytic transglycosylase activity
A4V09_RS11085	COG1196	nuclear chromosome segregation
A4V09_RS11115	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
A4V09_RS11125	COG0542	response to heat
A4V09_RS11135	COG0151	Belongs to the GarS family
A4V09_RS11140	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A4V09_RS11145	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
A4V09_RS11150	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A4V09_RS11175	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
A4V09_RS11180	COG0167	dihydroorotate dehydrogenase activity
A4V09_RS11190	COG0284	orotidine-5'-phosphate decarboxylase activity
A4V09_RS11195	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A4V09_RS11200	COG1278	Cold shock
A4V09_RS11205	COG3706	GGDEF domain
A4V09_RS11235	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
A4V09_RS11245	COG1122	ATPase activity
A4V09_RS11250	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A4V09_RS11255	COG0218	Necessary for normal cell division and for the maintenance of normal septation
A4V09_RS11260	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A4V09_RS11275	COG0544	peptidyl-prolyl cis-trans isomerase activity
A4V09_RS11295	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A4V09_RS11325	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A4V09_RS11345	COG1940	carbohydrate kinase activity
A4V09_RS11350	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
A4V09_RS11360	COG0674	pyruvate-flavodoxin oxidoreductase activity
A4V09_RS11380	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A4V09_RS11385	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A4V09_RS11395	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A4V09_RS11410	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A4V09_RS11425	COG1309	transcriptional regulator
A4V09_RS11445	COG3279	Response regulator of the LytR AlgR family
A4V09_RS11510	COG1309	transcriptional regulator
A4V09_RS11525	COG1136	(ABC) transporter
A4V09_RS11530	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A4V09_RS11535	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A4V09_RS11575	COG5426	von Willebrand factor, type A
A4V09_RS11580	COG1757	Na H antiporter
A4V09_RS11615	COG1959	2 iron, 2 sulfur cluster binding
A4V09_RS11650	COG0745	RESPONSE REGULATOR receiver
A4V09_RS11675	COG2233	PERMEase
A4V09_RS11680	COG1904	glucuronate isomerase
A4V09_RS11700	COG1609	Transcriptional regulator
A4V09_RS11705	COG2721	sulfolactate sulfo-lyase activity
A4V09_RS11720	COG4894	glucomannan catabolic process
A4V09_RS11725	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A4V09_RS11740	COG1523	belongs to the glycosyl hydrolase 13 family
A4V09_RS11780	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A4V09_RS11785	COG1309	transcriptional regulator
A4V09_RS11795	COG0756	dUTP diphosphatase activity
A4V09_RS11800	COG0602	queuosine metabolic process
A4V09_RS11805	COG1185	polyribonucleotide nucleotidyltransferase activity
A4V09_RS11810	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
A4V09_RS11815	COG0791	NLP P60 protein
A4V09_RS11820	COG0704	Plays a role in the regulation of phosphate uptake
A4V09_RS11825	COG0196	riboflavin kinase activity
A4V09_RS11830	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A4V09_RS11835	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
A4V09_RS11840	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
A4V09_RS11845	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A4V09_RS11855	COG2740	Nucleic-acid-binding protein implicated in transcription termination
A4V09_RS11860	COG0195	Participates in both transcription termination and antitermination
A4V09_RS11875	COG0598	Magnesium transport protein CorA
A4V09_RS11880	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A4V09_RS11885	COG0187	DNA topoisomerase II activity
A4V09_RS11890	COG0561	phosphatase activity
A4V09_RS11895	COG0671	phosphoesterase, PA-phosphatase related
A4V09_RS11900	COG0303	'Molybdopterin
A4V09_RS11905	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
A4V09_RS11910	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A4V09_RS11915	COG2414	aldehyde ferredoxin oxidoreductase
A4V09_RS11925	COG0281	malic enzyme
A4V09_RS11930	COG1027	Aspartate ammonia-lyase
A4V09_RS11940	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
A4V09_RS11945	COG1027	Aspartate ammonia-lyase
A4V09_RS11960	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A4V09_RS11965	COG0446	pyridine nucleotide-disulphide oxidoreductase
A4V09_RS11965	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A4V09_RS12000	COG5598	trimethylamine methyltransferase
A4V09_RS12015	COG3273	potassium ion transport
A4V09_RS12015	COG0471	metal ion transport
A4V09_RS12030	COG2508	Transcriptional regulator
A4V09_RS12055	COG0534	Mate efflux family protein
A4V09_RS12060	COG0613	PHP domain protein
A4V09_RS12080	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
A4V09_RS12090	COG4753	response regulator
A4V09_RS12090	COG2207	Transcriptional regulator
A4V09_RS12095	COG0395	ABC-type sugar transport system, permease component
A4V09_RS12100	COG1175	transmembrane transport
A4V09_RS12110	COG2972	Histidine kinase
A4V09_RS12115	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A4V09_RS12125	COG4667	esterase of the alpha-beta hydrolase superfamily
A4V09_RS12175	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A4V09_RS12185	COG0395	ABC-type sugar transport system, permease component
A4V09_RS12190	COG1175	transmembrane transport
A4V09_RS12200	COG3681	Belongs to the UPF0597 family
A4V09_RS12205	COG1979	alcohol dehydrogenase
A4V09_RS12210	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A4V09_RS12225	COG2084	Dehydrogenase
A4V09_RS12255	COG0038	chloride channel
A4V09_RS12260	COG1757	Na H antiporter
A4V09_RS12265	COG1012	belongs to the aldehyde dehydrogenase family
A4V09_RS12270	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
A4V09_RS12275	COG0784	Response regulator, receiver
A4V09_RS12275	COG2198	Histidine kinase
A4V09_RS12275	COG2205	protein histidine kinase activity
A4V09_RS12280	COG0840	transmembrane signaling receptor activity
A4V09_RS12330	COG1881	PFAM PEBP family protein
A4V09_RS12340	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A4V09_RS12345	COG1131	(ABC) transporter
A4V09_RS12360	COG2205	protein histidine kinase activity
A4V09_RS12425	COG3119	arylsulfatase activity
A4V09_RS12430	COG0395	ABC-type sugar transport system, permease component
A4V09_RS12435	COG1175	transmembrane transport
A4V09_RS12445	COG3279	Response regulator of the LytR AlgR family
A4V09_RS12450	COG2972	Histidine kinase
A4V09_RS12455	COG0641	radical SAM
A4V09_RS12485	COG0395	ABC-type sugar transport system, permease component
A4V09_RS12490	COG1175	transmembrane transport
A4V09_RS12500	COG2972	Histidine kinase
A4V09_RS12505	COG4753	response regulator
A4V09_RS12505	COG2207	Transcriptional regulator
A4V09_RS12530	COG3842	ATPase activity
A4V09_RS12535	COG1176	ABC-type spermidine putrescine transport system, permease component I
A4V09_RS12540	COG1177	transmembrane transport
A4V09_RS12545	COG0564	pseudouridine synthase activity
A4V09_RS12580	COG2205	protein histidine kinase activity
A4V09_RS12585	COG0745	RESPONSE REGULATOR receiver
A4V09_RS12585	COG2205	protein histidine kinase activity
A4V09_RS12585	COG4191	Histidine kinase
A4V09_RS12590	COG1854	S-ribosylhomocysteine lyase activity
A4V09_RS12595	COG5002	protein histidine kinase activity
A4V09_RS12595	COG5001	Diguanylate cyclase
A4V09_RS12605	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A4V09_RS12610	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
A4V09_RS12610	COG3608	succinylglutamate desuccinylase aspartoacylase
A4V09_RS12615	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A4V09_RS12615	COG0425	Belongs to the sulfur carrier protein TusA family
A4V09_RS12645	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A4V09_RS12650	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A4V09_RS12655	COG0549	Belongs to the carbamate kinase family
A4V09_RS12660	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A4V09_RS12665	COG0287	Prephenate dehydrogenase
A4V09_RS12670	COG3958	Transketolase
A4V09_RS12675	COG3959	Transketolase, thiamine diphosphate binding domain
A4V09_RS12680	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
A4V09_RS12680	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
A4V09_RS12685	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
A4V09_RS12690	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A4V09_RS12695	COG2186	Transcriptional regulator
A4V09_RS12710	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A4V09_RS12715	COG1253	flavin adenine dinucleotide binding
A4V09_RS12725	COG0395	ABC-type sugar transport system, permease component
A4V09_RS12730	COG4209	transmembrane transport
A4V09_RS12740	COG4753	response regulator
A4V09_RS12740	COG2207	Transcriptional regulator
A4V09_RS12745	COG2972	Histidine kinase
A4V09_RS12755	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A4V09_RS12765	COG0215	cysteine-tRNA ligase activity
A4V09_RS12770	COG1045	serine acetyltransferase
A4V09_RS12775	COG5001	Diguanylate cyclase
A4V09_RS12790	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A4V09_RS12795	COG0488	(ABC) transporter
A4V09_RS12800	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
A4V09_RS12810	COG1937	Protein conserved in bacteria
A4V09_RS12835	COG3708	Transcriptional regulator
A4V09_RS12835	COG2207	Transcriptional regulator
A4V09_RS12860	COG1069	ribulokinase activity
A4V09_RS12865	COG1609	Transcriptional regulator
A4V09_RS12915	COG1120	ATPase activity
A4V09_RS12920	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4V09_RS12925	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4V09_RS12985	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A4V09_RS13005	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
A4V09_RS13005	COG0674	pyruvate-flavodoxin oxidoreductase activity
A4V09_RS13010	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A4V09_RS13020	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A4V09_RS13025	COG1414	Transcriptional regulator
A4V09_RS13035	COG1937	Protein conserved in bacteria
A4V09_RS13050	COG1136	(ABC) transporter
A4V09_RS13050	COG0577	efflux transmembrane transporter activity
A4V09_RS13060	COG0601	transmembrane transport
A4V09_RS13095	COG2207	Transcriptional regulator
A4V09_RS13095	COG4753	response regulator
A4V09_RS13100	COG2972	Histidine kinase
A4V09_RS13105	COG1653	transport
A4V09_RS13110	COG1473	amidohydrolase
A4V09_RS13125	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A4V09_RS13135	COG0583	DNA-binding transcription factor activity
A4V09_RS13140	COG4608	Belongs to the ABC transporter superfamily
A4V09_RS13155	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A4V09_RS13160	COG0601	transmembrane transport
A4V09_RS13165	COG2226	methyltransferase
A4V09_RS13170	COG2226	methyltransferase
A4V09_RS13175	COG0251	oxidation-reduction process
A4V09_RS13180	COG1199	ATP-dependent helicase activity
A4V09_RS13180	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A4V09_RS13195	COG1937	Protein conserved in bacteria
A4V09_RS13205	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A4V09_RS13225	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A4V09_RS13230	COG1408	metallophosphoesterase
A4V09_RS13235	COG1104	cysteine desulfurase activity
A4V09_RS13245	COG0708	Exodeoxyribonuclease III
A4V09_RS13255	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
A4V09_RS13275	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A4V09_RS13285	COG0733	neurotransmitter:sodium symporter activity
A4V09_RS13295	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A4V09_RS13305	COG1063	alcohol dehydrogenase
A4V09_RS13310	COG0138	bifunctional purine biosynthesis protein purh
A4V09_RS13320	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A4V09_RS13345	COG0519	Catalyzes the synthesis of GMP from XMP
A4V09_RS13365	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A4V09_RS13365	COG0723	plastoquinol--plastocyanin reductase activity
A4V09_RS13380	COG1592	Rubrerythrin
A4V09_RS13385	COG2315	Protein conserved in bacteria
A4V09_RS13390	COG0028	Belongs to the TPP enzyme family
A4V09_RS13395	COG0440	acetolactate synthase activity
A4V09_RS13410	COG0242	peptide deformylase activity
A4V09_RS13415	COG0242	peptide deformylase activity
A4V09_RS13440	COG2207	Transcriptional regulator
A4V09_RS13440	COG3708	Transcriptional regulator
A4V09_RS13460	COG3344	reverse transcriptase
A4V09_RS13480	COG0745	RESPONSE REGULATOR receiver
A4V09_RS13495	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A4V09_RS13505	COG0037	tRNA processing
A4V09_RS13530	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
A4V09_RS13540	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A4V09_RS13550	COG0617	tRNA 3'-terminal CCA addition
A4V09_RS13555	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A4V09_RS13570	COG0698	ribose 5-phosphate isomerase
A4V09_RS13575	COG0009	L-threonylcarbamoyladenylate synthase
A4V09_RS13580	COG0860	N-Acetylmuramoyl-L-alanine amidase
A4V09_RS13605	COG4862	establishment of competence for transformation
A4V09_RS13620	COG2221	Nitrite and sulphite reductase 4Fe-4S
A4V09_RS13630	COG1028	Short-chain dehydrogenase reductase Sdr
A4V09_RS13650	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A4V09_RS13655	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A4V09_RS13660	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
A4V09_RS13665	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
A4V09_RS13680	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A4V09_RS13680	COG1328	CTP reductase activity
A4V09_RS13685	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A4V09_RS13715	COG0582	viral genome integration into host DNA
A4V09_RS13725	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A4V09_RS13735	COG0191	fructose-bisphosphate aldolase activity
A4V09_RS13745	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A4V09_RS13750	COG2890	protein-(glutamine-N5) methyltransferase activity
A4V09_RS13755	COG3872	metal-dependent enzyme
A4V09_RS13760	COG0254	rRNA binding
A4V09_RS13775	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A4V09_RS13780	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A4V09_RS13785	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A4V09_RS13795	COG1316	TRANSCRIPTIONal
A4V09_RS13805	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A4V09_RS13810	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A4V09_RS13820	COG0348	domain, Protein
A4V09_RS13820	COG3901	Regulator of nitric oxide reductase transcription
A4V09_RS13835	COG1063	alcohol dehydrogenase
A4V09_RS13840	COG1940	carbohydrate kinase activity
A4V09_RS13845	COG3706	GGDEF domain
A4V09_RS13860	COG0784	Response regulator, receiver
A4V09_RS13860	COG2205	protein histidine kinase activity
A4V09_RS13880	COG1028	Short-chain dehydrogenase reductase Sdr
A4V09_RS13925	COG0789	Transcriptional regulator
A4V09_RS13925	COG4978	Transcriptional regulator
A4V09_RS13930	COG1720	tRNA m6t6A37 methyltransferase activity
A4V09_RS13935	COG4154	Belongs to the RbsD FucU family
A4V09_RS13940	COG0235	Class ii aldolase
A4V09_RS13945	COG1070	Carbohydrate kinase
A4V09_RS13950	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
A4V09_RS13955	COG2207	Transcriptional regulator
A4V09_RS13955	COG1917	Cupin 2, conserved barrel domain protein
A4V09_RS13960	COG1022	Amp-dependent synthetase and ligase
A4V09_RS13965	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A4V09_RS13985	COG1309	transcriptional regulator
A4V09_RS13995	COG0789	Transcriptional regulator
A4V09_RS14000	COG2211	Major facilitator Superfamily
A4V09_RS14005	COG3622	Belongs to the hyi family
A4V09_RS14010	COG0673	inositol 2-dehydrogenase activity
A4V09_RS14025	COG4409	exo-alpha-(2->6)-sialidase activity
A4V09_RS14030	COG0673	inositol 2-dehydrogenase activity
A4V09_RS14045	COG1653	transport
A4V09_RS14050	COG0662	Cupin 2, conserved barrel domain protein
A4V09_RS14050	COG2207	Transcriptional regulator
A4V09_RS14110	COG1929	Belongs to the glycerate kinase type-1 family
A4V09_RS14115	COG3835	regulator
A4V09_RS14140	COG2721	sulfolactate sulfo-lyase activity
A4V09_RS14145	COG0246	Mannitol dehydrogenase
A4V09_RS14155	COG1063	alcohol dehydrogenase
A4V09_RS14170	COG0534	Mate efflux family protein
A4V09_RS14175	COG0110	maltose O-acetyltransferase activity
A4V09_RS14180	COG2207	Transcriptional regulator
A4V09_RS14180	COG1917	Cupin 2, conserved barrel domain protein
A4V09_RS14195	COG0513	Belongs to the DEAD box helicase family
A4V09_RS14210	COG0534	Mate efflux family protein
A4V09_RS14270	COG0519	Catalyzes the synthesis of GMP from XMP
A4V09_RS14275	COG1309	transcriptional regulator
A4V09_RS14310	COG4191	Histidine kinase
A4V09_RS14420	COG0740	serine-type endopeptidase activity
A4V09_RS14425	COG4695	Portal protein
A4V09_RS14480	COG4133	protoheme IX ABC transporter activity
A4V09_RS14485	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A4V09_RS14485	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A4V09_RS14565	COG1395	domain, Protein
A4V09_RS14595	COG4496	protein, YerC YecD
A4V09_RS14600	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
A4V09_RS14625	COG1242	4 iron, 4 sulfur cluster binding
A4V09_RS14635	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A4V09_RS14640	COG0726	polysaccharide deacetylase
A4V09_RS14650	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
A4V09_RS14650	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
A4V09_RS14675	COG0733	neurotransmitter:sodium symporter activity
A4V09_RS14685	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A4V09_RS14700	COG0653	protein targeting
A4V09_RS14745	COG3507	Belongs to the glycosyl hydrolase 43 family
A4V09_RS14750	COG0395	ABC-type sugar transport system, permease component
A4V09_RS14755	COG1175	transmembrane transport
A4V09_RS14760	COG1653	transport
A4V09_RS14765	COG1609	Transcriptional regulator
A4V09_RS14770	COG4753	response regulator
A4V09_RS14770	COG2207	Transcriptional regulator
A4V09_RS14775	COG3250	beta-galactosidase activity
A4V09_RS14790	COG0395	ABC-type sugar transport system, permease component
A4V09_RS14795	COG1175	transmembrane transport
A4V09_RS14800	COG1653	transport
A4V09_RS14805	COG2972	Histidine kinase
A4V09_RS14810	COG4753	response regulator
A4V09_RS14810	COG2207	Transcriptional regulator
A4V09_RS14830	COG0191	fructose-bisphosphate aldolase activity
A4V09_RS14855	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A4V09_RS14885	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A4V09_RS14890	COG2986	histidine ammonia-lyase
A4V09_RS14895	COG0583	DNA-binding transcription factor activity
A4V09_RS14910	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
A4V09_RS14920	COG1595	DNA-templated transcription, initiation
A4V09_RS14930	COG0165	Argininosuccinate lyase
A4V09_RS14935	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
A4V09_RS14960	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A4V09_RS14960	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
A4V09_RS14965	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A4V09_RS14970	COG1418	mRNA catabolic process
A4V09_RS14975	COG0302	gtp cyclohydrolase
A4V09_RS14980	COG0285	dihydrofolate synthase activity
A4V09_RS14990	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
A4V09_RS14995	COG3853	Toxic anion resistance protein (TelA)
A4V09_RS15005	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A4V09_RS15020	COG0733	neurotransmitter:sodium symporter activity
A4V09_RS15035	COG1079	Belongs to the binding-protein-dependent transport system permease family
A4V09_RS15040	COG4603	Belongs to the binding-protein-dependent transport system permease family
A4V09_RS15045	COG3845	ABC transporter
A4V09_RS15050	COG1744	ABC transporter substrate-binding protein PnrA-like
A4V09_RS15070	COG1811	Na channel or pump
A4V09_RS15075	COG3870	Protein conserved in bacteria
A4V09_RS15095	COG1396	sequence-specific DNA binding
A4V09_RS15115	COG1725	Transcriptional regulator
A4V09_RS15120	COG1131	(ABC) transporter
A4V09_RS15130	COG1501	Belongs to the glycosyl hydrolase 31 family
A4V09_RS15150	COG0395	ABC-type sugar transport system, permease component
A4V09_RS15165	COG4753	response regulator
A4V09_RS15165	COG2207	Transcriptional regulator
A4V09_RS15180	COG0517	IMP dehydrogenase activity
A4V09_RS15180	COG0516	GMP reductase activity
A4V09_RS15190	COG0459	protein refolding
A4V09_RS15195	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A4V09_RS15205	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A4V09_RS15210	COG0758	DNA mediated transformation
A4V09_RS15220	COG2207	Transcriptional regulator
A4V09_RS15235	COG0826	peptidase U32
A4V09_RS15255	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
A4V09_RS15270	COG4472	Bacterial protein of unknown function (DUF965)
A4V09_RS15275	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A4V09_RS15285	COG0301	tRNA thio-modification
A4V09_RS15290	COG1104	cysteine desulfurase activity
A4V09_RS15295	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A4V09_RS15300	COG2264	protein methyltransferase activity
A4V09_RS15330	COG1132	(ABC) transporter
A4V09_RS15340	COG1132	(ABC) transporter
A4V09_RS15350	COG0484	heat shock protein binding
A4V09_RS15355	COG0443	Heat shock 70 kDa protein
A4V09_RS15360	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A4V09_RS15365	COG1420	regulation of RNA biosynthetic process
A4V09_RS15375	COG1757	Na H antiporter
A4V09_RS15465	COG1013	pyruvate-flavodoxin oxidoreductase activity
A4V09_RS15475	COG2033	superoxide reductase activity
A4V09_RS15505	COG1082	Xylose isomerase domain protein TIM barrel
A4V09_RS15510	COG0673	inositol 2-dehydrogenase activity
A4V09_RS15515	COG1082	Xylose isomerase domain protein TIM barrel
A4V09_RS15520	COG2169	Transcriptional regulator
A4V09_RS15525	COG0235	Class ii aldolase
A4V09_RS15530	COG4806	L-rhamnose isomerase
A4V09_RS15535	COG1070	Carbohydrate kinase
A4V09_RS15545	COG3437	response regulator, receiver
A4V09_RS15555	COG0793	Belongs to the peptidase S41A family
A4V09_RS15560	COG2177	Part of the ABC transporter FtsEX involved in
A4V09_RS15565	COG2884	Cell division ATP-binding protein ftsE
A4V09_RS15570	COG3835	regulator
A4V09_RS15605	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A4V09_RS15615	COG0840	transmembrane signaling receptor activity
A4V09_RS15630	COG0840	transmembrane signaling receptor activity
A4V09_RS15635	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A4V09_RS15660	COG1597	lipid kinase activity
A4V09_RS15665	COG0203	ribosomal protein L17
A4V09_RS15670	COG0202	RNA polymerase activity
A4V09_RS15675	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A4V09_RS15680	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
A4V09_RS15685	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A4V09_RS15690	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A4V09_RS15700	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A4V09_RS15715	COG0563	adenylate kinase activity
A4V09_RS15725	COG0200	Binds to the 23S rRNA
A4V09_RS15735	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A4V09_RS15745	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A4V09_RS15750	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A4V09_RS15755	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A4V09_RS15775	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
A4V09_RS15780	COG0255	Belongs to the universal ribosomal protein uL29 family
A4V09_RS15785	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
A4V09_RS15795	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
A4V09_RS15805	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
A4V09_RS15820	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A4V09_RS15825	COG0051	transcription antitermination factor activity, RNA binding
A4V09_RS15830	COG0281	malic enzyme
A4V09_RS15840	COG1362	aminopeptidase activity
A4V09_RS15845	COG0383	alpha-mannosidase activity
A4V09_RS15855	COG1175	transmembrane transport
A4V09_RS15860	COG1653	transport
A4V09_RS15880	COG2972	Histidine kinase
A4V09_RS15890	COG2160	L-arabinose isomerase activity
A4V09_RS15900	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4V09_RS15905	COG1481	regulation of sporulation
A4V09_RS15920	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
A4V09_RS15940	COG2357	RelA SpoT domain protein
A4V09_RS15945	COG3250	beta-galactosidase activity
A4V09_RS15955	COG1653	transport
A4V09_RS15960	COG0395	ABC-type sugar transport system, permease component
A4V09_RS15965	COG4209	transmembrane transport
A4V09_RS15980	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A4V09_RS15990	COG1486	melibiose metabolic process
A4V09_RS15995	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A4V09_RS16000	COG0395	ABC-type sugar transport system, permease component
A4V09_RS16010	COG4209	transmembrane transport
A4V09_RS16020	COG1796	DNA polymerase
A4V09_RS16020	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
A4V09_RS16035	COG2972	Histidine kinase
A4V09_RS16040	COG4753	response regulator
A4V09_RS16040	COG2207	Transcriptional regulator
A4V09_RS16050	COG4753	response regulator
A4V09_RS16050	COG2207	Transcriptional regulator
A4V09_RS16055	COG3275	phosphorelay sensor kinase activity
A4V09_RS16085	COG2378	regulation of single-species biofilm formation
A4V09_RS16140	COG2340	Cysteine-rich secretory protein family
A4V09_RS16145	COG1983	PspC domain protein
A4V09_RS16170	COG1132	(ABC) transporter
A4V09_RS16180	COG3290	protein histidine kinase activity
A4V09_RS16190	COG1115	amino acid carrier protein
A4V09_RS16195	COG1074	ATP-dependent DNA helicase activity
A4V09_RS16200	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
A4V09_RS16205	COG0561	phosphatase activity
A4V09_RS16240	COG1609	Transcriptional regulator
A4V09_RS16265	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
A4V09_RS16290	COG3275	phosphorelay sensor kinase activity
A4V09_RS16295	COG0395	ABC-type sugar transport system, permease component
A4V09_RS16300	COG4209	transmembrane transport
A4V09_RS16310	COG0657	acetylesterase activity
A4V09_RS16310	COG2755	lipolytic protein G-D-S-L family
A4V09_RS16330	COG2207	Transcriptional regulator
A4V09_RS16330	COG4753	response regulator
A4V09_RS16340	COG0395	ABC-type sugar transport system, permease component
A4V09_RS16345	COG4209	transmembrane transport
A4V09_RS16350	COG1472	Belongs to the glycosyl hydrolase 3 family
A4V09_RS16365	COG1501	Belongs to the glycosyl hydrolase 31 family
A4V09_RS16375	COG0426	domain, Protein
A4V09_RS16385	COG0791	NLP P60 protein
A4V09_RS16405	COG0437	4 iron, 4 sulfur cluster binding
A4V09_RS16405	COG3064	Membrane
A4V09_RS16410	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
A4V09_RS16420	COG0531	amino acid
A4V09_RS16425	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A4V09_RS16440	COG0657	acetylesterase activity
A4V09_RS16455	COG1362	aminopeptidase activity
A4V09_RS16460	COG0531	amino acid
A4V09_RS16465	COG2080	2 iron, 2 sulfur cluster binding
A4V09_RS16465	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A4V09_RS16480	COG0534	Mate efflux family protein
A4V09_RS16490	COG1691	(AIR) carboxylase
A4V09_RS16500	COG0534	Mate efflux family protein
A4V09_RS16505	COG3534	alpha-L-arabinofuranosidase
A4V09_RS16510	COG0395	ABC-type sugar transport system, permease component
A4V09_RS16515	COG1175	transmembrane transport
A4V09_RS16520	COG1653	transport
A4V09_RS16530	COG3534	alpha-L-arabinofuranosidase
A4V09_RS16540	COG3940	Belongs to the glycosyl hydrolase 43 family
A4V09_RS16545	COG1288	antiporter activity
A4V09_RS16570	COG0179	Fumarylacetoacetate (FAA) hydrolase
A4V09_RS16575	COG1522	sequence-specific DNA binding
A4V09_RS16585	COG1994	Peptidase M50
A4V09_RS16610	COG1511	domain protein
A4V09_RS16630	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A4V09_RS16640	COG1528	Iron-storage protein
A4V09_RS16650	COG2855	membrane
A4V09_RS16655	COG0583	DNA-binding transcription factor activity
A4V09_RS16670	COG2207	Transcriptional regulator
A4V09_RS16670	COG3708	Transcriptional regulator
A4V09_RS16675	COG1312	Catalyzes the dehydration of D-mannonate
A4V09_RS16680	COG0246	Mannitol dehydrogenase
A4V09_RS16695	COG3300	MHYT domain
A4V09_RS16695	COG5001	Diguanylate cyclase
A4V09_RS16765	COG4974	Belongs to the 'phage' integrase family
A4V09_RS16780	COG0656	L-ascorbic acid biosynthetic process
A4V09_RS16785	COG1063	alcohol dehydrogenase
A4V09_RS16790	COG3250	beta-galactosidase activity
A4V09_RS16800	COG3958	Transketolase
A4V09_RS16805	COG3959	Transketolase, thiamine diphosphate binding domain
A4V09_RS16830	COG3275	phosphorelay sensor kinase activity
A4V09_RS16835	COG1501	Belongs to the glycosyl hydrolase 31 family
A4V09_RS16840	COG1874	Beta-galactosidase
A4V09_RS16860	COG0395	ABC-type sugar transport system, permease component
A4V09_RS16865	COG4209	transmembrane transport
A4V09_RS16915	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
A4V09_RS16920	COG1053	succinate dehydrogenase
A4V09_RS16950	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
A4V09_RS16965	COG0039	L-malate dehydrogenase activity
A4V09_RS16970	COG2205	protein histidine kinase activity
A4V09_RS16975	COG0745	RESPONSE REGULATOR receiver
A4V09_RS17035	COG0366	Alpha amylase catalytic
A4V09_RS17040	COG0395	ABC-type sugar transport system, permease component
A4V09_RS17045	COG1175	transmembrane transport
A4V09_RS17050	COG1653	transport
A4V09_RS17055	COG1609	Transcriptional regulator
A4V09_RS17085	COG3958	Transketolase
A4V09_RS17090	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
A4V09_RS17100	COG1609	Transcriptional regulator
A4V09_RS17105	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A4V09_RS17110	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
A4V09_RS17115	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A4V09_RS17120	COG0205	6-phosphofructokinase activity
A4V09_RS17135	COG0586	Pfam SNARE associated Golgi protein
A4V09_RS17140	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
A4V09_RS17140	COG0646	methionine synthase
A4V09_RS17145	COG0590	tRNA wobble adenosine to inosine editing
A4V09_RS17180	COG1609	Transcriptional regulator
A4V09_RS17185	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
A4V09_RS17185	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A4V09_RS17205	COG2088	sporulation resulting in formation of a cellular spore
A4V09_RS17210	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
A4V09_RS17215	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
A4V09_RS17235	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A4V09_RS17240	COG0840	transmembrane signaling receptor activity
A4V09_RS17260	COG0017	Asparaginyl-tRNA synthetase
A4V09_RS17275	COG0445	tRNA wobble uridine modification
A4V09_RS17280	COG0395	ABC-type sugar transport system, permease component
A4V09_RS17285	COG1175	transmembrane transport
A4V09_RS17295	COG4753	response regulator
A4V09_RS17295	COG2207	Transcriptional regulator
A4V09_RS17300	COG3275	phosphorelay sensor kinase activity
A4V09_RS17335	COG0768	penicillin binding
A4V09_RS17340	COG0544	peptidyl-prolyl cis-trans isomerase activity
A4V09_RS17355	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A4V09_RS17370	COG0697	spore germination
A4V09_RS17375	COG1802	Transcriptional regulator
A4V09_RS17380	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
A4V09_RS17400	COG0534	Mate efflux family protein
A4V09_RS17410	COG0534	Mate efflux family protein
A4V09_RS17420	COG1518	maintenance of DNA repeat elements
A4V09_RS17450	COG3842	ATPase activity
A4V09_RS17490	COG2801	Transposase and inactivated derivatives
A4V09_RS17525	COG0110	maltose O-acetyltransferase activity
A4V09_RS17530	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A4V09_RS17540	COG1181	Belongs to the D-alanine--D-alanine ligase family
A4V09_RS17550	COG0456	acetyltransferase
A4V09_RS17555	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A4V09_RS17560	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A4V09_RS17575	COG0582	viral genome integration into host DNA
A4V09_RS17580	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A4V09_RS17595	COG2207	Transcriptional regulator
A4V09_RS17615	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A4V09_RS17625	COG0116	Belongs to the methyltransferase superfamily
A4V09_RS17625	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A4V09_RS17635	COG3850	Histidine kinase
A4V09_RS17635	COG5002	protein histidine kinase activity
A4V09_RS17650	COG0252	asparaginase activity
A4V09_RS17665	COG2205	protein histidine kinase activity
A4V09_RS17680	COG2197	response regulator
A4V09_RS17695	COG3426	butyrate kinase activity
A4V09_RS17710	COG0657	acetylesterase activity
A4V09_RS17745	COG0457	Tetratricopeptide repeat
A4V09_RS17750	COG1966	Carbon starvation protein
A4V09_RS17765	COG1151	hydroxylamine reductase activity
A4V09_RS17780	COG1509	lysine 2,3-aminomutase activity
A4V09_RS17800	COG5001	Diguanylate cyclase
A4V09_RS17810	COG1028	Short-chain dehydrogenase reductase Sdr
A4V09_RS17815	COG3958	Transketolase
A4V09_RS17820	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
A4V09_RS17830	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
A4V09_RS17835	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A4V09_RS17845	COG1595	DNA-templated transcription, initiation
A4V09_RS17855	COG0577	efflux transmembrane transporter activity
A4V09_RS17855	COG1136	(ABC) transporter
A4V09_RS17865	COG0745	RESPONSE REGULATOR receiver
A4V09_RS17875	COG3655	Transcriptional regulator
A4V09_RS17905	COG1609	Transcriptional regulator
A4V09_RS17920	COG0534	Mate efflux family protein
A4V09_RS17925	COG1653	transport
A4V09_RS17930	COG0395	ABC-type sugar transport system, permease component
A4V09_RS17940	COG3250	beta-galactosidase activity
A4V09_RS17945	COG1609	Transcriptional regulator
A4V09_RS17950	COG2222	sugar isomerase
A4V09_RS17955	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A4V09_RS17965	COG2188	Transcriptional regulator
A4V09_RS17975	COG1695	Transcriptional regulator
A4V09_RS17980	COG1917	Cupin 2, conserved barrel domain protein
A4V09_RS17980	COG2207	Transcriptional regulator
A4V09_RS17985	COG0534	Mate efflux family protein
A4V09_RS17990	COG0110	maltose O-acetyltransferase activity
A4V09_RS18005	COG0395	ABC-type sugar transport system, permease component
A4V09_RS18010	COG4209	transmembrane transport
A4V09_RS18020	COG0745	RESPONSE REGULATOR receiver
A4V09_RS18025	COG5002	protein histidine kinase activity
A4V09_RS18035	COG1136	(ABC) transporter
A4V09_RS18040	COG2201	protein-glutamate methylesterase activity
A4V09_RS18055	COG1193	negative regulation of DNA recombination
A4V09_RS18070	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A4V09_RS18075	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A4V09_RS18080	COG0049	tRNA binding
A4V09_RS18085	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
A4V09_RS18095	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A4V09_RS18100	COG0085	RNA polymerase activity
A4V09_RS18115	COG3620	sequence-specific DNA binding
A4V09_RS18120	COG0222	ribosome binding
A4V09_RS18140	COG1388	LysM domain
A4V09_RS18140	COG3858	chitin binding
A4V09_RS18150	COG4974	Belongs to the 'phage' integrase family
A4V09_RS18160	COG0081	regulation of translation
A4V09_RS18170	COG0250	Participates in transcription elongation, termination and antitermination
A4V09_RS18180	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A4V09_RS18205	COG1073	alpha beta
A4V09_RS18210	COG2723	6-phospho-beta-galactosidase activity
A4V09_RS18225	COG0673	inositol 2-dehydrogenase activity
A4V09_RS18230	COG1028	Short-chain dehydrogenase reductase Sdr
A4V09_RS18235	COG1175	transmembrane transport
A4V09_RS18240	COG0395	ABC-type sugar transport system, permease component
A4V09_RS18250	COG0346	lactoylglutathione lyase activity
A4V09_RS18260	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A4V09_RS18265	COG4608	Belongs to the ABC transporter superfamily
A4V09_RS18270	COG0444	Belongs to the ABC transporter superfamily
A4V09_RS18280	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A4V09_RS18285	COG0601	transmembrane transport
A4V09_RS18290	COG0747	negative chemotaxis
A4V09_RS18310	COG1228	amidohydrolase
A4V09_RS18340	COG4978	Transcriptional regulator
A4V09_RS18340	COG0789	Transcriptional regulator
A4V09_RS18350	COG1136	(ABC) transporter
A4V09_RS18360	COG0745	RESPONSE REGULATOR receiver
A4V09_RS18395	COG1401	restriction endodeoxyribonuclease activity
A4V09_RS18405	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A4V09_RS18405	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A4V09_RS18465	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A4V09_RS18550	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A4V09_RS18655	COG1733	regulation of RNA biosynthetic process
A4V09_RS18665	COG0640	Transcriptional regulator
A4V09_RS18670	COG0640	Transcriptional regulator
A4V09_RS18675	COG2217	Heavy metal translocating P-type atpase
A4V09_RS18690	COG1937	Protein conserved in bacteria
A4V09_RS18695	COG0534	Mate efflux family protein
A4V09_RS18720	COG1733	regulation of RNA biosynthetic process
A4V09_RS18745	COG4509	Sortase family
A4V09_RS18755	COG1309	transcriptional regulator
A4V09_RS18765	COG2814	Major facilitator Superfamily
A4V09_RS18795	COG1396	sequence-specific DNA binding
A4V09_RS18830	COG1129	ABC transporter
A4V09_RS18830	COG0842	Transport permease protein
A4V09_RS18845	COG2239	Acts as a magnesium transporter
A4V09_RS18850	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A4V09_RS18860	COG5002	protein histidine kinase activity
A4V09_RS18865	COG0745	RESPONSE REGULATOR receiver
A4V09_RS18895	COG0483	inositol monophosphate 1-phosphatase activity
A4V09_RS18915	COG0745	RESPONSE REGULATOR receiver
A4V09_RS18920	COG2378	regulation of single-species biofilm formation
A4V09_RS18935	COG0534	Mate efflux family protein
A4V09_RS18950	COG1309	transcriptional regulator
A4V09_RS19000	COG0745	RESPONSE REGULATOR receiver
A4V09_RS19005	COG5002	protein histidine kinase activity
A4V09_RS19010	COG1136	(ABC) transporter
A4V09_RS19055	COG0577	efflux transmembrane transporter activity
A4V09_RS19060	COG1136	(ABC) transporter
A4V09_RS19065	COG5002	protein histidine kinase activity
A4V09_RS19150	COG0483	inositol monophosphate 1-phosphatase activity
A4V09_RS19190	COG4474	Belongs to the UPF0398 family
A4V09_RS19200	COG0681	Belongs to the peptidase S26 family
A4V09_RS19220	COG3177	Filamentation induced by cAMP protein fic
A4V09_RS19310	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
A4V09_RS19315	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A4V09_RS19320	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A4V09_RS19325	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
A4V09_RS19335	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
A4V09_RS19335	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
A4V09_RS19360	COG1136	(ABC) transporter
A4V09_RS19365	COG2252	PERMEase
A4V09_RS19370	COG2205	protein histidine kinase activity
A4V09_RS19390	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A4V09_RS19395	COG0569	domain protein
A4V09_RS19400	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A4V09_RS19415	COG0500	methyltransferase
A4V09_RS19420	COG2996	Protein conserved in bacteria
A4V09_RS19440	COG3279	Response regulator of the LytR AlgR family
A4V09_RS19495	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A4V09_RS19500	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
A4V09_RS19510	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A4V09_RS19520	COG1830	Aldolase
A4V09_RS19525	COG1063	alcohol dehydrogenase
A4V09_RS19530	COG1737	Transcriptional regulator
A4V09_RS19535	COG1876	peptidase activity
A4V09_RS19540	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
A4V09_RS19545	COG2002	toxin-antitoxin pair type II binding
A4V09_RS19555	COG4750	Nucleotidyl transferase
A4V09_RS19560	COG1213	nucleotidyl transferase
A4V09_RS19570	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
A4V09_RS19580	COG1486	melibiose metabolic process
A4V09_RS19585	COG2207	Transcriptional regulator
A4V09_RS19605	COG1486	melibiose metabolic process
A4V09_RS19615	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
A4V09_RS19620	COG2207	Transcriptional regulator
A4V09_RS19630	COG0110	maltose O-acetyltransferase activity
A4V09_RS19650	COG1216	Glycosyl transferase, family 2
A4V09_RS19655	COG1215	transferase activity, transferring glycosyl groups
A4V09_RS19665	COG0463	Glycosyl transferase, family 2
A4V09_RS19665	COG1216	Glycosyl transferase, family 2
A4V09_RS19670	COG1216	Glycosyl transferase, family 2
A4V09_RS19680	COG3475	LICD family
A4V09_RS19695	COG0438	transferase activity, transferring glycosyl groups
A4V09_RS19710	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A4V09_RS19720	COG4509	Sortase family
A4V09_RS19740	COG3944	biosynthesis protein
A4V09_RS19765	COG2207	Transcriptional regulator
A4V09_RS19775	COG0395	ABC-type sugar transport system, permease component
A4V09_RS19780	COG1175	transmembrane transport
A4V09_RS19805	COG1175	transmembrane transport
A4V09_RS19820	COG1940	carbohydrate kinase activity
A4V09_RS19830	COG0673	inositol 2-dehydrogenase activity
A4V09_RS19835	COG0366	Alpha amylase catalytic
A4V09_RS19840	COG0395	ABC-type sugar transport system, permease component
A4V09_RS19865	COG5012	cobalamin binding
A4V09_RS19885	COG5012	cobalamin binding
A4V09_RS19895	COG3835	regulator
A4V09_RS19910	COG0110	maltose O-acetyltransferase activity
A4V09_RS19915	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A4V09_RS19925	COG2205	protein histidine kinase activity
A4V09_RS19925	COG0784	Response regulator, receiver
A4V09_RS19950	COG1846	Transcriptional regulator
A4V09_RS19950	COG1940	carbohydrate kinase activity
A4V09_RS19955	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A4V09_RS19965	COG1592	Rubrerythrin
A4V09_RS19970	COG1592	Rubrerythrin
A4V09_RS19970	COG1773	rubredoxin
A4V09_RS19975	COG0735	belongs to the Fur family
A4V09_RS19980	COG1737	Transcriptional regulator
A4V09_RS19990	COG2731	YhcH YjgK YiaL family protein
A4V09_RS19995	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A4V09_RS20000	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A4V09_RS20005	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
A4V09_RS20010	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
A4V09_RS20020	COG0791	NLP P60 protein
A4V09_RS20035	COG0275	rRNA processing
A4V09_RS20040	COG2873	o-acetylhomoserine
A4V09_RS20045	COG0534	Mate efflux family protein
A4V09_RS20125	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A4V09_RS20130	COG0187	DNA topoisomerase II activity
A4V09_RS20135	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A4V09_RS20145	COG0592	DNA-directed DNA polymerase activity
A4V09_RS20150	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A4V09_RS20155	COG0230	Belongs to the bacterial ribosomal protein bL34 family
A4V09_RS20160	COG0594	ribonuclease P activity
A4V09_RS20170	COG0706	membrane insertase activity
A4V09_RS20175	COG1847	R3H domain protein
A4V09_RS20180	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A4V09_RS20185	COG0445	tRNA wobble uridine modification
A4V09_RS20190	COG0357	Ribosomal RNA small subunit methyltransferase G
A4V09_RS20215	COG1131	(ABC) transporter
A4V09_RS20245	COG1192	Involved in chromosome partitioning
A4V09_RS20250	COG1475	DNA binding
A4V09_RS20260	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A4V09_RS20270	COG5001	Diguanylate cyclase
A4V09_RS20270	COG5002	protein histidine kinase activity
A4V09_RS20275	COG2972	Histidine kinase
A4V09_RS20280	COG2207	Transcriptional regulator
A4V09_RS20280	COG4753	response regulator
A4V09_RS20295	COG0395	ABC-type sugar transport system, permease component
A4V09_RS20315	COG1396	sequence-specific DNA binding
A4V09_RS20335	COG0004	ammonium transporteR
A4V09_RS20340	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
A4V09_RS20360	COG0504	CTP synthase activity
A4V09_RS20365	COG0070	glutamate synthase
A4V09_RS20365	COG0067	glutamate synthase
A4V09_RS20365	COG0069	glutamate synthase activity
A4V09_RS20370	COG0493	'glutamate synthase
A4V09_RS20380	COG0514	ATP-dependent DNA helicase (RecQ)
A4V09_RS20395	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
A4V09_RS20400	COG1459	type II secretion system
A4V09_RS20415	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A4V09_RS20455	COG0436	Aminotransferase
A4V09_RS20460	COG0017	Asparaginyl-tRNA synthetase
A4V09_RS20465	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A4V09_RS20480	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A4V09_RS20485	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A4V09_RS20500	COG1686	Belongs to the peptidase S11 family
A4V09_RS20505	COG2188	Transcriptional regulator
A4V09_RS20510	COG1131	(ABC) transporter
A4V09_RS20530	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A4V09_RS20535	COG0058	SHG alpha-glucan phosphorylase activity
A4V09_RS20545	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A4V09_RS20555	COG3842	ATPase activity
A4V09_RS20575	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A4V09_RS20575	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A4V09_RS20585	COG3250	beta-galactosidase activity
A4V09_RS20590	COG2211	Major facilitator Superfamily
A4V09_RS20600	COG4086	secreted protein
A4V09_RS20605	COG2357	RelA SpoT domain protein
A4V09_RS20630	COG1501	Belongs to the glycosyl hydrolase 31 family
A4V09_RS20635	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A4V09_RS20640	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A4V09_RS20645	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A4V09_RS20670	COG3708	Transcriptional regulator
A4V09_RS20670	COG2207	Transcriptional regulator
A4V09_RS20680	COG1175	transmembrane transport
A4V09_RS20685	COG0395	ABC-type sugar transport system, permease component
A4V09_RS20695	COG1063	alcohol dehydrogenase
A4V09_RS20705	COG2610	gluconate transmembrane transporter activity
A4V09_RS20710	COG2186	Transcriptional regulator
A4V09_RS20715	COG0129	dihydroxy-acid dehydratase activity
A4V09_RS20720	COG1028	Short-chain dehydrogenase reductase Sdr
A4V09_RS20725	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A4V09_RS20740	COG5002	protein histidine kinase activity
A4V09_RS20745	COG0745	RESPONSE REGULATOR receiver
A4V09_RS20780	COG0442	prolyl-tRNA aminoacylation
A4V09_RS20785	COG1982	Orn Lys Arg decarboxylase major
A4V09_RS20785	COG1982	Orn Lys Arg decarboxylase major
A4V09_RS20790	COG0194	GDP metabolic process
A4V09_RS20800	COG1774	PSP1 C-terminal conserved region
A4V09_RS20805	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
A4V09_RS20810	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
A4V09_RS20815	COG2843	Capsule synthesis protein
A4V09_RS20820	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A4V09_RS20825	COG2715	membrane protein required for spore maturation
A4V09_RS20830	COG1609	Transcriptional regulator
A4V09_RS20835	COG1609	Transcriptional regulator
A4V09_RS20845	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A4V09_RS20850	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A4V09_RS20865	COG1028	Short-chain dehydrogenase reductase Sdr
A4V09_RS20870	COG3959	Transketolase, thiamine diphosphate binding domain
A4V09_RS20875	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A4V09_RS20880	COG1063	alcohol dehydrogenase
A4V09_RS20885	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A4V09_RS20895	COG0149	triose-phosphate isomerase activity
A4V09_RS20915	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A4V09_RS20920	COG0069	glutamate synthase activity
A4V09_RS20925	COG0534	Mate efflux family protein
A4V09_RS20950	COG0395	ABC-type sugar transport system, permease component
A4V09_RS20955	COG4753	response regulator
A4V09_RS20955	COG2207	Transcriptional regulator
A4V09_RS20960	COG2972	Histidine kinase
A4V09_RS20970	COG3345	alpha-galactosidase
A4V09_RS20980	COG1917	Cupin 2, conserved barrel domain protein
A4V09_RS20980	COG2207	Transcriptional regulator
A4V09_RS20985	COG0673	inositol 2-dehydrogenase activity
A4V09_RS20990	COG1082	Xylose isomerase domain protein TIM barrel
A4V09_RS20995	COG1082	Xylose isomerase domain protein TIM barrel
A4V09_RS21000	COG2211	Major facilitator Superfamily
A4V09_RS21010	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A4V09_RS21010	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A4V09_RS21025	COG1486	melibiose metabolic process
A4V09_RS21030	COG2971	BadF BadG BcrA BcrD
A4V09_RS21040	COG1175	transmembrane transport
A4V09_RS21045	COG0395	ABC-type sugar transport system, permease component
A4V09_RS21050	COG0363	glucosamine-6-phosphate deaminase activity
A4V09_RS21070	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A4V09_RS21075	COG0628	permease
A4V09_RS21080	COG0084	hydrolase, TatD family'
A4V09_RS21085	COG1309	transcriptional regulator
A4V09_RS21100	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A4V09_RS21105	COG0631	protein serine/threonine phosphatase activity
A4V09_RS21225	COG0352	thiamine-phosphate diphosphorylase activity
A4V09_RS21235	COG2022	thiamine diphosphate biosynthetic process
A4V09_RS21240	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A4V09_RS21245	COG2104	thiamine diphosphate biosynthetic process
A4V09_RS21250	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
A4V09_RS21260	COG4977	sequence-specific DNA binding
A4V09_RS21275	COG1757	Na H antiporter
A4V09_RS21280	COG0745	RESPONSE REGULATOR receiver
A4V09_RS21290	COG1136	(ABC) transporter
A4V09_RS21300	COG0523	cobalamin synthesis protein
A4V09_RS21315	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A4V09_RS21335	COG2059	Chromate
A4V09_RS21360	COG0700	Nucleoside recognition
A4V09_RS21365	COG0784	Response regulator, receiver
A4V09_RS21365	COG2198	Histidine kinase
A4V09_RS21365	COG2205	protein histidine kinase activity
A4V09_RS21370	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
A4V09_RS21375	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
A4V09_RS21380	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A4V09_RS21385	COG0131	Imidazoleglycerol-phosphate dehydratase
A4V09_RS21390	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
A4V09_RS21400	COG0107	imidazoleglycerol-phosphate synthase activity
A4V09_RS21405	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
A4V09_RS21405	COG0140	phosphoribosyl-ATP diphosphatase activity
A4V09_RS21410	COG0140	phosphoribosyl-ATP diphosphatase activity
A4V09_RS21430	COG1175	transmembrane transport
A4V09_RS21435	COG0395	ABC-type sugar transport system, permease component
A4V09_RS21440	COG1486	melibiose metabolic process
A4V09_RS21450	COG1063	alcohol dehydrogenase
A4V09_RS21460	COG4869	propanediol catabolic process
A4V09_RS21470	COG1105	Belongs to the carbohydrate kinase PfkB family
A4V09_RS21475	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A4V09_RS21475	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A4V09_RS21475	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4V09_RS21485	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A4V09_RS21490	COG1349	DNA-binding transcription factor activity
A4V09_RS21525	COG0492	ferredoxin-NADP+ reductase activity
A4V09_RS21530	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
A4V09_RS21535	COG5002	protein histidine kinase activity
A4V09_RS21545	COG0704	Plays a role in the regulation of phosphate uptake
A4V09_RS21550	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A4V09_RS21555	COG0581	inorganic phosphate transmembrane transporter activity
A4V09_RS21560	COG0573	inorganic phosphate transmembrane transporter activity
A4V09_RS21575	COG1394	ATPase activity, coupled to movement of substances
A4V09_RS21585	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
A4V09_RS21605	COG1269	ATP hydrolysis coupled proton transport
A4V09_RS21620	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A4V09_RS21730	COG0733	neurotransmitter:sodium symporter activity
A4V09_RS21735	COG2201	protein-glutamate methylesterase activity
A4V09_RS21740	COG3275	phosphorelay sensor kinase activity
A4V09_RS21770	COG0281	malic enzyme
A4V09_RS21800	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A4V09_RS21865	COG1716	ATPase activity
A4V09_RS21870	COG0457	Tetratricopeptide repeat
A4V09_RS21870	COG0705	Rhomboid family
A4V09_RS21875	COG5002	protein histidine kinase activity
A4V09_RS21880	COG0537	adenosine 5'-monophosphoramidase activity
A4V09_RS21890	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A4V09_RS21930	COG1695	Transcriptional regulator
A4V09_RS21945	COG2197	response regulator
A4V09_RS21950	COG4585	Histidine kinase
A4V09_RS21955	COG1131	(ABC) transporter
A4V09_RS21990	COG1131	(ABC) transporter
A4V09_RS22020	COG3279	Response regulator of the LytR AlgR family
A4V09_RS22110	COG0129	dihydroxy-acid dehydratase activity
A4V09_RS22125	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A4V09_RS22135	COG1104	cysteine desulfurase activity
A4V09_RS22150	COG2226	methyltransferase
A4V09_RS22160	COG1233	COG1233 Phytoene dehydrogenase and related
A4V09_RS22175	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A4V09_RS22180	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A4V09_RS22190	COG0166	Belongs to the GPI family
A4V09_RS22210	COG5002	protein histidine kinase activity
A4V09_RS22215	COG3842	ATPase activity
A4V09_RS22220	COG3835	regulator
A4V09_RS22225	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
A4V09_RS22230	COG0564	pseudouridine synthase activity
A4V09_RS22240	COG1879	ABC-type sugar transport system periplasmic component
A4V09_RS22250	COG1269	ATP hydrolysis coupled proton transport
A4V09_RS22255	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A4V09_RS22270	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
A4V09_RS22275	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
A4V09_RS22280	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
A4V09_RS22285	COG1394	ATPase activity, coupled to movement of substances
A4V09_RS22290	COG2223	nitrite transmembrane transporter activity
A4V09_RS22310	COG1472	Belongs to the glycosyl hydrolase 3 family
A4V09_RS22320	COG2706	6-phosphogluconolactonase activity
A4V09_RS22325	COG0534	Mate efflux family protein
A4V09_RS22330	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
A4V09_RS22335	COG2333	competence protein COMEC
A4V09_RS22335	COG0658	competence protein
A4V09_RS22345	COG1609	Transcriptional regulator
A4V09_RS22355	COG0519	Catalyzes the synthesis of GMP from XMP
A4V09_RS22410	COG0582	viral genome integration into host DNA
A4V09_RS22420	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
A4V09_RS22485	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A4V09_RS22495	COG1940	carbohydrate kinase activity
A4V09_RS22500	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
A4V09_RS22510	COG0546	phosphoglycolate phosphatase activity
A4V09_RS22515	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A4V09_RS22535	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A4V09_RS22540	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A4V09_RS22545	COG0535	radical SAM domain protein
A4V09_RS22575	COG1216	Glycosyl transferase, family 2
A4V09_RS22575	COG0463	Glycosyl transferase, family 2
A4V09_RS22580	COG0318	PFAM AMP-dependent synthetase and ligase
A4V09_RS22590	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A4V09_RS22595	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
A4V09_RS22595	COG1605	Chorismate mutase
A4V09_RS22600	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A4V09_RS22605	COG1131	(ABC) transporter
A4V09_RS22620	COG1484	DNA-dependent DNA replication
A4V09_RS22675	COG3550	peptidyl-serine autophosphorylation
A4V09_RS22725	COG1609	Transcriptional regulator
A4V09_RS22730	COG4209	transmembrane transport
A4V09_RS22735	COG0395	ABC-type sugar transport system, permease component
A4V09_RS22765	COG4753	response regulator
A4V09_RS22765	COG2207	Transcriptional regulator
A4V09_RS22770	COG2972	Histidine kinase
A4V09_RS22780	COG1175	transmembrane transport
A4V09_RS22810	COG2972	Histidine kinase
A4V09_RS22815	COG2207	Transcriptional regulator
A4V09_RS22815	COG4753	response regulator
A4V09_RS22825	COG1175	transmembrane transport
A4V09_RS22830	COG0395	ABC-type sugar transport system, permease component
A4V09_RS22850	COG0737	Belongs to the 5'-nucleotidase family
A4V09_RS22860	COG1309	transcriptional regulator
A4V09_RS22865	COG1131	(ABC) transporter
A4V09_RS22875	COG2814	Major facilitator Superfamily
A4V09_RS22880	COG2267	carboxylic ester hydrolase activity
A4V09_RS22920	COG1595	DNA-templated transcription, initiation
A4V09_RS22930	COG1131	(ABC) transporter
A4V09_RS22960	COG3275	phosphorelay sensor kinase activity
A4V09_RS22965	COG4753	response regulator
A4V09_RS22965	COG2207	Transcriptional regulator
A4V09_RS22970	COG1472	Belongs to the glycosyl hydrolase 3 family
A4V09_RS22985	COG0745	RESPONSE REGULATOR receiver
A4V09_RS22990	COG5002	protein histidine kinase activity
A4V09_RS23010	COG1971	Probably functions as a manganese efflux pump
A4V09_RS23020	COG1115	amino acid carrier protein
A4V09_RS23025	COG0726	polysaccharide deacetylase
A4V09_RS23035	COG1454	alcohol dehydrogenase
A4V09_RS23035	COG1012	belongs to the aldehyde dehydrogenase family
A4V09_RS23040	COG1217	gtp-binding protein TYPA
A4V09_RS23050	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
A4V09_RS23055	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A4V09_RS23060	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
A4V09_RS23070	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
A4V09_RS23075	COG1924	4 iron, 4 sulfur cluster binding
A4V09_RS23080	COG0653	protein targeting
A4V09_RS23090	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
A4V09_RS23095	COG4492	Belongs to the UPF0735 family
A4V09_RS23100	COG0460	homoserine dehydrogenase
A4V09_RS23105	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
A4V09_RS23135	COG1070	Carbohydrate kinase
A4V09_RS23140	COG2183	response to ionizing radiation
A4V09_RS23145	COG0006	proline dipeptidase activity
A4V09_RS23160	COG4753	response regulator
A4V09_RS23160	COG2207	Transcriptional regulator
A4V09_RS23165	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A4V09_RS23165	COG2207	Transcriptional regulator
A4V09_RS23170	COG1609	Transcriptional regulator
A4V09_RS23175	COG4209	transmembrane transport
A4V09_RS23180	COG0395	ABC-type sugar transport system, permease component
A4V09_RS23195	COG2207	Transcriptional regulator
A4V09_RS23200	COG0534	Mate efflux family protein
A4V09_RS23205	COG3250	beta-galactosidase activity
A4V09_RS23265	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
A4V09_RS23270	COG1028	Short-chain dehydrogenase reductase Sdr
A4V09_RS23290	COG4753	response regulator
A4V09_RS23290	COG2207	Transcriptional regulator
A4V09_RS23295	COG2972	Histidine kinase
A4V09_RS23305	COG1175	transmembrane transport
A4V09_RS23310	COG0395	ABC-type sugar transport system, permease component
A4V09_RS23325	COG2161	toxin-antitoxin pair type II binding
A4V09_RS23335	COG1396	sequence-specific DNA binding
A4V09_RS23340	COG1309	transcriptional regulator
A4V09_RS23350	COG0582	viral genome integration into host DNA
A4V09_RS23355	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
A4V09_RS23365	COG0628	permease
A4V09_RS23370	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A4V09_RS23375	COG0569	domain protein
A4V09_RS23380	COG2205	protein histidine kinase activity
A4V09_RS23385	COG0745	RESPONSE REGULATOR receiver
A4V09_RS23395	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
A4V09_RS23405	COG1696	Membrane protein involved in D-alanine export
A4V09_RS23410	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A4V09_RS23420	COG2759	Belongs to the formate--tetrahydrofolate ligase family
A4V09_RS23425	COG2116	formate transmembrane transporter activity
A4V09_RS23435	COG1132	(ABC) transporter
A4V09_RS23440	COG0436	Aminotransferase
A4V09_RS23455	COG1940	carbohydrate kinase activity
A4V09_RS23460	COG1653	transport
A4V09_RS23465	COG1175	transmembrane transport
A4V09_RS23480	COG1940	carbohydrate kinase activity
A4V09_RS23485	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
A4V09_RS23495	COG3250	beta-galactosidase activity
A4V09_RS23500	COG1609	Transcriptional regulator
A4V09_RS23520	COG1501	Belongs to the glycosyl hydrolase 31 family
A4V09_RS23545	COG0622	Phosphoesterase
A4V09_RS23550	COG0116	Belongs to the methyltransferase superfamily
A4V09_RS23555	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A4V09_RS23560	COG0622	Phosphoesterase
A4V09_RS23600	COG2801	Transposase and inactivated derivatives
A4V09_RS23645	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
A4V09_RS23680	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A4V09_RS23685	COG3962	Belongs to the TPP enzyme family
A4V09_RS23705	COG2211	Major facilitator Superfamily
A4V09_RS23715	COG0673	inositol 2-dehydrogenase activity
A4V09_RS23720	COG3275	phosphorelay sensor kinase activity
A4V09_RS23725	COG2207	Transcriptional regulator
A4V09_RS23725	COG4753	response regulator
A4V09_RS23755	COG0673	inositol 2-dehydrogenase activity
A4V09_RS23760	COG1082	Xylose isomerase domain protein TIM barrel
A4V09_RS23765	COG1349	DNA-binding transcription factor activity
A4V09_RS23770	COG2223	nitrite transmembrane transporter activity
A4V09_RS23785	COG2207	Transcriptional regulator
A4V09_RS23785	COG0662	Cupin 2, conserved barrel domain protein
A4V09_RS23800	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A4V09_RS23810	COG2986	histidine ammonia-lyase
A4V09_RS23815	COG1757	Na H antiporter
A4V09_RS23825	COG1773	rubredoxin
A4V09_RS23835	COG0583	DNA-binding transcription factor activity
A4V09_RS23840	COG0446	pyridine nucleotide-disulphide oxidoreductase
A4V09_RS23850	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
A4V09_RS23855	COG0534	Mate efflux family protein
A4V09_RS23860	COG1328	CTP reductase activity
A4V09_RS23865	COG0475	glutathione-regulated potassium exporter activity
A4V09_RS23890	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A4V09_RS23900	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A4V09_RS23910	COG5002	protein histidine kinase activity
A4V09_RS23915	COG0745	RESPONSE REGULATOR receiver
A4V09_RS23920	COG1193	negative regulation of DNA recombination
A4V09_RS23925	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A4V09_RS23930	COG3481	metal-dependent phosphohydrolase, HD sub domain
A4V09_RS23935	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A4V09_RS24010	COG4166	transmembrane transport
A4V09_RS24015	COG0601	transmembrane transport
A4V09_RS24020	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A4V09_RS24025	COG0444	Belongs to the ABC transporter superfamily
A4V09_RS24030	COG4608	Belongs to the ABC transporter superfamily
A4V09_RS24040	COG1349	DNA-binding transcription factor activity