locus-tag	class	description
M9396_RS00005	COG1181	Belongs to the D-alanine--D-alanine ligase family
M9396_RS00015	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
M9396_RS00020	COG0302	gtp cyclohydrolase
M9396_RS00035	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
M9396_RS00035	COG0140	phosphoribosyl-ATP diphosphatase activity
M9396_RS00040	COG0107	imidazoleglycerol-phosphate synthase activity
M9396_RS00045	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
M9396_RS00055	COG0131	Imidazoleglycerol-phosphate dehydratase
M9396_RS00055	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
M9396_RS00060	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
M9396_RS00065	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
M9396_RS00070	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
M9396_RS00075	COG2925	Exonuclease
M9396_RS00080	COG2926	Belongs to the UPF0265 family
M9396_RS00105	COG2814	Major facilitator Superfamily
M9396_RS00115	COG0018	arginyl-trna synthetase
M9396_RS00120	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
M9396_RS00125	COG0739	heme binding
M9396_RS00130	COG0469	pyruvate kinase activity
M9396_RS00135	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
M9396_RS00150	COG3716	PTS system mannose fructose sorbose family IID component
M9396_RS00155	COG3715	PTS system
M9396_RS00160	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
M9396_RS00160	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M9396_RS00165	COG1253	flavin adenine dinucleotide binding
M9396_RS00170	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
M9396_RS00180	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
M9396_RS00185	COG2894	cell division
M9396_RS00190	COG0850	regulation of cytokinetic process
M9396_RS00195	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
M9396_RS00205	COG0616	signal peptide processing
M9396_RS00210	COG0708	Exodeoxyribonuclease III
M9396_RS00220	COG1435	thymidine kinase activity
M9396_RS00225	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M9396_RS00240	COG0159	tryptophan synthase activity
M9396_RS00245	COG0133	tryptophan synthase activity
M9396_RS00250	COG0134	indole-3-glycerol-phosphate synthase activity
M9396_RS00250	COG0135	phosphoribosylanthranilate isomerase activity
M9396_RS00255	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
M9396_RS00260	COG0512	Glutamine amidotransferase of anthranilate synthase
M9396_RS00260	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
M9396_RS00265	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
M9396_RS00270	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
M9396_RS00275	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
M9396_RS00280	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M9396_RS00285	COG1448	Aminotransferase
M9396_RS00290	COG0017	Asparaginyl-tRNA synthetase
M9396_RS00295	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
M9396_RS00300	COG3785	DNA binding
M9396_RS00305	COG2920	part of a sulfur-relay system
M9396_RS00320	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
M9396_RS00335	COG1376	ErfK ybiS ycfS ynhG family protein
M9396_RS00340	COG1376	ErfK ybiS ycfS ynhG family protein
M9396_RS00345	COG1560	Kdo2-lipid A biosynthetic process
M9396_RS00350	COG1530	ribonuclease E activity
M9396_RS00355	COG0564	pseudouridine synthase activity
M9396_RS00360	COG0333	Belongs to the bacterial ribosomal protein bL32 family
M9396_RS00365	COG0416	fatty acid biosynthetic process
M9396_RS00370	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M9396_RS00385	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M9396_RS00390	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M9396_RS00395	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
M9396_RS00400	COG0470	DNA polymerase III
M9396_RS00405	COG0084	hydrolase, TatD family'
M9396_RS00410	COG0537	adenosine 5'-monophosphoramidase activity
M9396_RS00415	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
M9396_RS00420	COG4591	ABC-type transport system involved in lipoprotein release permease component
M9396_RS00425	COG1136	(ABC) transporter
M9396_RS00430	COG4591	ABC-type transport system involved in lipoprotein release permease component
M9396_RS00435	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
M9396_RS00440	COG0482	sulfurtransferase activity
M9396_RS00445	COG1321	iron dependent repressor
M9396_RS00465	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
M9396_RS00470	COG0492	ferredoxin-NADP+ reductase activity
M9396_RS00475	COG1674	ftsk spoiiie
M9396_RS00485	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
M9396_RS00490	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
M9396_RS00495	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
M9396_RS00500	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
M9396_RS00505	COG0539	negative regulation of cytoplasmic translation
M9396_RS00510	COG1132	(ABC) transporter
M9396_RS00515	COG1663	tetraacyldisaccharide 4'-kinase activity
M9396_RS00520	COG2835	tetraacyldisaccharide 4'-kinase activity
M9396_RS00525	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
M9396_RS00540	COG0114	fumarate hydratase activity
M9396_RS00545	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
M9396_RS00550	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
M9396_RS00555	COG0259	pyridoxamine-phosphate oxidase activity
M9396_RS00560	COG1846	Transcriptional regulator
M9396_RS00565	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M9396_RS00570	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
M9396_RS00575	COG0307	riboflavin synthase, alpha
M9396_RS00590	COG2166	iron-sulfur cluster assembly
M9396_RS00600	COG0719	Fe-S assembly protein
M9396_RS00605	COG0396	ATPase activity
M9396_RS00610	COG0719	Fe-S assembly protein
M9396_RS00615	COG0316	Belongs to the HesB IscA family
M9396_RS00620	COG0095	Lipoate-protein ligase
M9396_RS00625	COG0072	phenylalanine-tRNA ligase activity
M9396_RS00625	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M9396_RS00630	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
M9396_RS00635	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
M9396_RS00640	COG0291	Belongs to the bacterial ribosomal protein bL35 family
M9396_RS00645	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
M9396_RS00650	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
M9396_RS00665	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
M9396_RS00675	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
M9396_RS00680	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
M9396_RS00685	COG0193	aminoacyl-tRNA hydrolase activity
M9396_RS00690	COG0012	GTP binding
M9396_RS00695	COG0670	Belongs to the BI1 family
M9396_RS00700	COG0588	phosphoglycerate mutase activity
M9396_RS00705	COG2706	6-phosphogluconolactonase activity
M9396_RS00710	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
M9396_RS00715	COG2885	chlorophyll binding
M9396_RS00720	COG0823	Involved in the tonB-independent uptake of proteins
M9396_RS00730	COG0848	biopolymer transport protein
M9396_RS00735	COG0811	peptide transport
M9396_RS00740	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
M9396_RS00745	COG0045	succinate-CoA ligase (ADP-forming) activity
M9396_RS00750	COG0508	dehydrogenase complex catalyzes the overall conversion of
M9396_RS00755	COG0567	Dehydrogenase, E1 component
M9396_RS00760	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
M9396_RS00765	COG1053	succinate dehydrogenase
M9396_RS00780	COG0033	Phosphoglucomutase
M9396_RS00785	COG0596	Alpha beta hydrolase
M9396_RS00790	COG0716	FMN binding
M9396_RS00795	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M9396_RS00800	COG0363	glucosamine-6-phosphate deaminase activity
M9396_RS00805	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
M9396_RS00825	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M9396_RS00835	COG1702	phosphate starvation-inducible protein PhoH
M9396_RS00840	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
M9396_RS00850	COG0815	Transfers the fatty acyl group on membrane lipoproteins
M9396_RS00855	COG0495	leucyl-tRNA aminoacylation
M9396_RS00860	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
M9396_RS00870	COG0799	negative regulation of ribosome biogenesis
M9396_RS00875	COG0768	penicillin binding
M9396_RS00880	COG0772	Belongs to the SEDS family
M9396_RS00885	COG0697	spore germination
M9396_RS00895	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
M9396_RS00900	COG0215	cysteine-tRNA ligase activity
M9396_RS00905	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M9396_RS00910	COG0563	adenylate kinase activity
M9396_RS00920	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
M9396_RS00935	COG0312	modulator of DNA gyrase
M9396_RS00940	COG0312	modulator of DNA gyrase
M9396_RS00950	COG1792	Involved in formation and maintenance of cell shape
M9396_RS00955	COG1077	Cell shape determining protein MreB Mrl
M9396_RS00960	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
M9396_RS00965	COG0511	ligase activity, forming carbon-carbon bonds
M9396_RS00970	COG0439	Biotin carboxylase
M9396_RS00975	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
M9396_RS00980	COG0442	prolyl-tRNA aminoacylation
M9396_RS00985	COG0037	tRNA processing
M9396_RS00990	COG0825	malonyl-CoA metabolic process
M9396_RS00995	COG0587	DNA-directed DNA polymerase activity
M9396_RS01000	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
M9396_RS01005	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M9396_RS01010	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M9396_RS01015	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
M9396_RS01020	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M9396_RS01025	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
M9396_RS01030	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M9396_RS01035	COG0750	zinc metalloprotease
M9396_RS01040	COG0575	Belongs to the CDS family
M9396_RS01045	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
M9396_RS01050	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
M9396_RS01055	COG0233	cytoplasmic translational termination
M9396_RS01060	COG0528	UMP kinase activity
M9396_RS01065	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
M9396_RS01070	COG0052	Belongs to the universal ribosomal protein uS2 family
M9396_RS01075	COG0024	Methionine aminopeptidase
M9396_RS01080	COG2171	N-acyltransferase activity
M9396_RS01085	COG1074	ATP-dependent DNA helicase activity
M9396_RS01090	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M9396_RS01095	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
M9396_RS01100	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
M9396_RS01105	COG0494	nUDIX hydrolase
M9396_RS01115	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
M9396_RS01125	COG0354	folic acid binding
M9396_RS01130	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M9396_RS01135	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M9396_RS01140	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
M9396_RS01145	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
M9396_RS01150	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
M9396_RS01155	COG0191	fructose-bisphosphate aldolase activity
M9396_RS01160	COG0126	phosphoglycerate kinase activity
M9396_RS01165	COG0010	Belongs to the arginase family
M9396_RS01170	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
M9396_RS01175	COG1678	Uncharacterized ACR, COG1678
M9396_RS01180	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
M9396_RS01185	COG1194	a g-specific adenine glycosylase
M9396_RS01190	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
M9396_RS01195	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
M9396_RS01200	COG0740	serine-type endopeptidase activity
M9396_RS01205	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
M9396_RS01210	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
M9396_RS01220	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
M9396_RS01225	COG0109	protoheme IX farnesyltransferase activity
M9396_RS01230	COG2814	Major facilitator Superfamily
M9396_RS01235	COG0301	tRNA thio-modification
M9396_RS01235	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M9396_RS01240	COG0142	geranyltranstransferase activity
M9396_RS01245	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
M9396_RS01250	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
M9396_RS01255	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M9396_RS01260	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
M9396_RS01265	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M9396_RS01265	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M9396_RS01270	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M9396_RS01275	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M9396_RS01280	COG1862	Preprotein translocase
M9396_RS01285	COG0343	queuine tRNA-ribosyltransferase activity
M9396_RS01290	COG0450	alkyl hydroperoxide reductase
M9396_RS01300	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
M9396_RS01310	COG0328	RNA-DNA hybrid ribonuclease activity
M9396_RS01315	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M9396_RS01325	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
M9396_RS01330	COG0009	L-threonylcarbamoyladenylate synthase
M9396_RS01335	COG0242	peptide deformylase activity
M9396_RS01340	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
M9396_RS01345	COG0203	ribosomal protein L17
M9396_RS01350	COG0202	RNA polymerase activity
M9396_RS01355	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
M9396_RS01360	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
M9396_RS01365	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
M9396_RS01370	COG0257	Belongs to the bacterial ribosomal protein bL36 family
M9396_RS01375	COG0201	protein transport
M9396_RS01380	COG0200	Binds to the 23S rRNA
M9396_RS01385	COG1841	ribosomal large subunit assembly
M9396_RS01390	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
M9396_RS01395	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
M9396_RS01400	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
M9396_RS01405	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
M9396_RS01410	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
M9396_RS01415	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
M9396_RS01420	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
M9396_RS01425	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
M9396_RS01430	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
M9396_RS01435	COG0255	Belongs to the universal ribosomal protein uL29 family
M9396_RS01440	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
M9396_RS01445	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
M9396_RS01450	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
M9396_RS01455	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
M9396_RS01460	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
M9396_RS01465	COG0089	rRNA binding
M9396_RS01470	COG0088	Forms part of the polypeptide exit tunnel
M9396_RS01475	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
M9396_RS01480	COG0051	transcription antitermination factor activity, RNA binding
M9396_RS01510	COG1072	(Pantothenic acid kinase))
M9396_RS01515	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
M9396_RS01515	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
M9396_RS01520	COG0812	UDP-N-acetylmuramate dehydrogenase activity
M9396_RS01525	COG0542	response to heat
M9396_RS01530	COG0564	pseudouridine synthase activity
M9396_RS01535	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M9396_RS01540	COG0077	Prephenate dehydratase
M9396_RS01540	COG1605	Chorismate mutase
M9396_RS01545	COG0287	Prephenate dehydrogenase
M9396_RS01545	COG1605	Chorismate mutase
M9396_RS01555	COG0335	large ribosomal subunit rRNA binding
M9396_RS01560	COG0336	Belongs to the RNA methyltransferase TrmD family
M9396_RS01565	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
M9396_RS01570	COG0228	four-way junction DNA binding
M9396_RS01575	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
M9396_RS01590	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
M9396_RS01595	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
M9396_RS01600	COG1388	LysM domain
M9396_RS01600	COG4942	peptidase
M9396_RS01605	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
M9396_RS01610	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
M9396_RS01615	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
M9396_RS01620	COG0529	Catalyzes the synthesis of activated sulfate
M9396_RS01625	COG2895	sulfate adenylyltransferase (ATP) activity
M9396_RS01630	COG0175	sulfate reduction
M9396_RS01635	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
M9396_RS01635	COG1648	precorrin-2 dehydrogenase activity
M9396_RS01640	COG0175	sulfate reduction
M9396_RS01645	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M9396_RS01650	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
M9396_RS01655	COG0148	phosphopyruvate hydratase activity
M9396_RS01660	COG0504	CTP synthase activity
M9396_RS01665	COG0316	Belongs to the HesB IscA family
M9396_RS01670	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M9396_RS01675	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
M9396_RS01680	COG0508	dehydrogenase complex catalyzes the overall conversion of
M9396_RS01685	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M9396_RS01700	COG0237	dephospho-CoA kinase activity
M9396_RS01705	COG0653	protein targeting
M9396_RS01710	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
M9396_RS01720	COG0849	cell division
M9396_RS01725	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
M9396_RS01730	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
M9396_RS01735	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
M9396_RS01740	COG0772	Belongs to the SEDS family
M9396_RS01745	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
M9396_RS01750	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M9396_RS01755	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
M9396_RS01760	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
M9396_RS01765	COG0768	penicillin binding
M9396_RS01770	COG3116	cell division
M9396_RS01775	COG0275	rRNA processing
M9396_RS01780	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M9396_RS01785	COG0473	3-isopropylmalate dehydrogenase activity
M9396_RS01790	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
M9396_RS01795	COG0066	3-isopropylmalate dehydratase activity
M9396_RS01800	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
M9396_RS01805	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M9396_RS01810	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
M9396_RS01815	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
M9396_RS01830	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
M9396_RS01835	COG0505	Belongs to the CarA family
M9396_RS01840	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
M9396_RS01845	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
M9396_RS01850	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
M9396_RS01855	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
M9396_RS01860	COG0196	riboflavin kinase activity
M9396_RS01865	COG0268	Binds directly to 16S ribosomal RNA
M9396_RS01870	COG0484	heat shock protein binding
M9396_RS01875	COG0443	Heat shock 70 kDa protein
M9396_RS01880	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
M9396_RS01885	COG0083	homoserine kinase activity
M9396_RS01900	COG0513	Belongs to the DEAD box helicase family
M9396_RS01905	COG1185	polyribonucleotide nucleotidyltransferase activity
M9396_RS01910	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
M9396_RS01915	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
M9396_RS01920	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
M9396_RS01925	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
M9396_RS01930	COG0195	Participates in both transcription termination and antitermination
M9396_RS01945	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
M9396_RS01950	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M9396_RS01955	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
M9396_RS01965	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
M9396_RS01970	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M9396_RS01975	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
M9396_RS01980	COG0211	Belongs to the bacterial ribosomal protein bL27 family
M9396_RS01985	COG0261	This protein binds to 23S rRNA in the presence of protein L20
M9396_RS01990	COG0142	geranyltranstransferase activity
M9396_RS01995	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
M9396_RS02000	COG2911	Protein conserved in bacteria
M9396_RS02005	COG0729	surface antigen
M9396_RS02015	COG1218	3'(2'),5'-bisphosphate nucleotidase
M9396_RS02020	COG0359	binds to the 23S rRNA
M9396_RS02025	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
M9396_RS02030	COG0360	Binds together with S18 to 16S ribosomal RNA
M9396_RS02035	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M9396_RS02040	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
M9396_RS02045	COG0330	HflC and HflK could
M9396_RS02050	COG0330	HflC and HflK could
M9396_RS02055	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
M9396_RS02065	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
M9396_RS02070	COG0860	N-Acetylmuramoyl-L-alanine amidase
M9396_RS02075	COG0802	atpase or kinase
M9396_RS02085	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
M9396_RS02090	COG0688	phosphatidylethanolamine metabolic process
M9396_RS02095	COG3264	Mechanosensitive ion channel
M9396_RS02095	COG1511	domain protein
M9396_RS02100	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
M9396_RS02105	COG0459	protein refolding
M9396_RS02110	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
M9396_RS02125	COG0626	cystathionine gamma-synthase activity
M9396_RS02130	COG0204	Acyl-transferase
M9396_RS02135	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
M9396_RS02140	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
M9396_RS02140	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
M9396_RS02145	COG0617	tRNA 3'-terminal CCA addition
M9396_RS02150	COG1968	undecaprenyl-diphosphatase activity
M9396_RS02160	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
M9396_RS02165	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
M9396_RS02170	COG0828	Belongs to the bacterial ribosomal protein bS21 family
M9396_RS02175	COG0358	DNA primase activity
M9396_RS02190	COG0586	Pfam SNARE associated Golgi protein
M9396_RS02200	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
M9396_RS02205	COG2823	Periplasmic or secreted lipoprotein
M9396_RS02210	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
M9396_RS02215	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
M9396_RS02225	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M9396_RS02230	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
M9396_RS02235	COG5007	Belongs to the BolA IbaG family
M9396_RS02240	COG3117	lipopolysaccharide transmembrane transporter activity
M9396_RS02250	COG1137	ATPase activity
M9396_RS02255	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M9396_RS02260	COG1121	(ABC) transporter
M9396_RS02275	COG0795	lipopolysaccharide-transporting ATPase activity
M9396_RS02280	COG0795	lipopolysaccharide-transporting ATPase activity
M9396_RS02285	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
M9396_RS02290	COG2927	DNA polymerase III (CHI subunit)
M9396_RS02295	COG0525	valine-tRNA ligase activity
M9396_RS02300	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
M9396_RS02310	COG1301	dicarboxylic acid transport
M9396_RS02315	COG0025	NhaP-type Na H and K H
M9396_RS02320	COG0629	single-stranded DNA binding
M9396_RS02330	COG0735	belongs to the Fur family
M9396_RS02335	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
M9396_RS02340	COG0306	phosphate transporter
M9396_RS02355	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M9396_RS02360	COG0751	glycine-tRNA ligase activity
M9396_RS02365	COG0752	glycyl-tRNA synthetase alpha subunit
M9396_RS02375	COG0071	Belongs to the small heat shock protein (HSP20) family
M9396_RS02380	COG0187	DNA topoisomerase II activity
M9396_RS02390	COG0230	Belongs to the bacterial ribosomal protein bL34 family
M9396_RS02395	COG0594	ribonuclease P activity
M9396_RS02400	COG0706	membrane insertase activity
M9396_RS02405	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
M9396_RS02410	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
M9396_RS02415	COG0355	proton-transporting ATP synthase activity, rotational mechanism
M9396_RS02420	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
M9396_RS02425	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
M9396_RS02430	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
M9396_RS02435	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
M9396_RS02440	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
M9396_RS02450	COG0356	it plays a direct role in the translocation of protons across the membrane
M9396_RS02455	COG0445	tRNA wobble uridine modification
M9396_RS02465	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
M9396_RS02470	COG0166	Belongs to the GPI family
M9396_RS02475	COG0742	ribosomal rna small subunit methyltransferase
M9396_RS02480	COG0552	protein localization to endoplasmic reticulum
M9396_RS02490	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
M9396_RS02495	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
M9396_RS02500	COG1322	Protein conserved in bacteria
M9396_RS02505	COG2226	methyltransferase
M9396_RS02510	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
M9396_RS02515	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
M9396_RS02530	COG0218	Necessary for normal cell division and for the maintenance of normal septation
M9396_RS02545	COG0194	GDP metabolic process
M9396_RS02550	COG1846	Transcriptional regulator
M9396_RS02555	COG1561	YicC-like family, N-terminal region
M9396_RS02560	COG0756	dUTP diphosphatase activity
M9396_RS02565	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
M9396_RS02570	COG0227	Belongs to the bacterial ribosomal protein bL28 family
M9396_RS02575	COG0267	Belongs to the bacterial ribosomal protein bL33 family
M9396_RS02580	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
M9396_RS02585	COG1519	Transferase
M9396_RS02595	COG0859	PFAM glycosyl transferase family 9
M9396_RS02600	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M9396_RS02605	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M9396_RS02610	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
M9396_RS02615	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
M9396_RS02620	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
M9396_RS02625	COG1045	serine acetyltransferase
M9396_RS02630	COG0205	6-phosphofructokinase activity
M9396_RS02635	COG0149	triose-phosphate isomerase activity
M9396_RS02640	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M9396_RS02645	COG0254	rRNA binding
M9396_RS02650	COG0626	cystathionine gamma-synthase activity
M9396_RS02660	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
M9396_RS02685	COG3978	acetolactate synthase activity
M9396_RS02695	COG0129	dihydroxy-acid dehydratase activity
M9396_RS02705	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
M9396_RS02710	COG3118	belongs to the thioredoxin family
M9396_RS02740	COG1587	Uroporphyrinogen-III synthase
M9396_RS02745	COG0181	hydroxymethylbilane synthase activity
M9396_RS02750	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
M9396_RS02755	COG1011	Hydrolase
M9396_RS02775	COG0210	DNA helicase
M9396_RS02780	COG0210	DNA helicase
M9396_RS02785	COG0598	Magnesium transport protein CorA
M9396_RS02790	COG0561	phosphatase activity
M9396_RS02795	COG2095	MarC family integral membrane protein
M9396_RS02805	COG0316	Belongs to the HesB IscA family
M9396_RS02805	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
M9396_RS02810	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
M9396_RS02815	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
M9396_RS02820	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
M9396_RS02825	COG0180	Tryptophanyl-tRNA synthetase
M9396_RS02830	COG0512	Glutamine amidotransferase of anthranilate synthase
M9396_RS02835	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
M9396_RS02840	COG0049	tRNA binding
M9396_RS02845	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
M9396_RS02850	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
M9396_RS02855	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
M9396_RS02860	COG0250	Participates in transcription elongation, termination and antitermination
M9396_RS02865	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
M9396_RS02870	COG0081	regulation of translation
M9396_RS02875	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
M9396_RS02880	COG0222	ribosome binding
M9396_RS02885	COG0085	RNA polymerase activity
M9396_RS02890	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
M9396_RS02915	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M9396_RS02930	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
M9396_RS02935	COG2867	negative regulation of translational initiation
M9396_RS02945	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
M9396_RS02950	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
M9396_RS02955	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
M9396_RS02960	COG0481	GTPase activity
M9396_RS02965	COG0681	Belongs to the peptidase S26 family
M9396_RS02970	COG0571	ribonuclease III activity
M9396_RS02975	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
M9396_RS02980	COG0736	holo-[acyl-carrier-protein] synthase activity
M9396_RS02990	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
M9396_RS02995	COG0483	inositol monophosphate 1-phosphatase activity
M9396_RS03005	COG0105	UTP biosynthetic process
M9396_RS03010	COG0820	rRNA (adenine-C2-)-methyltransferase activity
M9396_RS03015	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
M9396_RS03020	COG0124	histidyl-tRNA synthetase
M9396_RS03025	COG1160	GTP binding
M9396_RS03030	COG0579	oxidoreductase
M9396_RS03035	COG0516	GMP reductase activity
M9396_RS03035	COG0517	IMP dehydrogenase activity
M9396_RS03040	COG0518	GMP synthase (glutamine-hydrolyzing) activity
M9396_RS03040	COG0519	Catalyzes the synthesis of GMP from XMP
M9396_RS03045	COG0829	nickel cation binding
M9396_RS03050	COG0831	urea catabolic process
M9396_RS03055	COG0832	Belongs to the urease beta subunit family
M9396_RS03060	COG0804	urea catabolic process
M9396_RS03065	COG0830	nickel cation binding
M9396_RS03070	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
M9396_RS03075	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
M9396_RS03080	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
M9396_RS03085	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M9396_RS03095	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M9396_RS03100	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
M9396_RS03110	COG4150	thiosulfate binding
M9396_RS03115	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
M9396_RS03120	COG4208	sulfate ABC transporter
M9396_RS03135	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M9396_RS03145	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
M9396_RS03160	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M9396_RS03170	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M9396_RS03175	COG1914	H( )-stimulated, divalent metal cation uptake system
M9396_RS03185	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
M9396_RS03190	COG2890	protein-(glutamine-N5) methyltransferase activity
M9396_RS03195	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M9396_RS03200	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M9396_RS03205	COG0101	tRNA pseudouridine synthase activity
M9396_RS03210	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
M9396_RS03215	COG0285	dihydrofolate synthase activity
M9396_RS03220	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M9396_RS03225	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M9396_RS03230	COG0649	NAD binding
M9396_RS03230	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M9396_RS03235	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
M9396_RS03240	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
M9396_RS03245	COG1034	ATP synthesis coupled electron transport
M9396_RS03250	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
M9396_RS03255	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M9396_RS03260	COG0839	Belongs to the complex I subunit 6 family
M9396_RS03265	COG0713	ATP synthesis coupled electron transport
M9396_RS03270	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M9396_RS03275	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M9396_RS03280	COG1007	ATP synthesis coupled electron transport
M9396_RS03285	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M9396_RS03290	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M9396_RS03295	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides