locus-tag	class	description
GT348_RS00020	COG0463	Glycosyl transferase, family 2
GT348_RS00025	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GT348_RS00030	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GT348_RS00035	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GT348_RS00040	COG0356	it plays a direct role in the translocation of protons across the membrane
GT348_RS00090	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GT348_RS00105	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GT348_RS00115	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GT348_RS00120	COG0193	aminoacyl-tRNA hydrolase activity
GT348_RS00130	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GT348_RS00135	COG0799	negative regulation of ribosome biogenesis
GT348_RS00140	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GT348_RS00155	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GT348_RS00165	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GT348_RS00230	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GT348_RS00235	COG1959	2 iron, 2 sulfur cluster binding
GT348_RS00240	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GT348_RS00240	COG1648	precorrin-2 dehydrogenase activity
GT348_RS00270	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GT348_RS00280	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GT348_RS00295	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GT348_RS00300	COG0196	riboflavin kinase activity
GT348_RS00310	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GT348_RS00325	COG0277	FAD linked oxidase domain protein
GT348_RS00350	COG3180	Ammonia monooxygenase
GT348_RS00365	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
GT348_RS00375	COG0191	fructose-bisphosphate aldolase activity
GT348_RS00385	COG0778	Nitroreductase
GT348_RS00400	COG4957	zinc ion binding
GT348_RS00415	COG0815	Transfers the fatty acyl group on membrane lipoproteins
GT348_RS00420	COG1396	sequence-specific DNA binding
GT348_RS00445	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
GT348_RS00465	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GT348_RS00475	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GT348_RS00480	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
GT348_RS00485	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
GT348_RS00490	COG0552	protein localization to endoplasmic reticulum
GT348_RS00495	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GT348_RS00500	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GT348_RS00505	COG2226	methyltransferase
GT348_RS00510	COG0513	Belongs to the DEAD box helicase family
GT348_RS00515	COG4221	oxidoreductase activity
GT348_RS00520	COG1678	Uncharacterized ACR, COG1678
GT348_RS00575	COG1064	alcohol dehydrogenase
GT348_RS00580	COG1764	response to oxidative stress
GT348_RS00585	COG1064	alcohol dehydrogenase
GT348_RS00590	COG2943	transferase activity, transferring hexosyl groups
GT348_RS00595	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
GT348_RS00605	COG4106	trans-aconitate 2-methyltransferase activity
GT348_RS00605	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GT348_RS00615	COG0156	8-amino-7-oxononanoate synthase activity
GT348_RS00670	COG1216	Glycosyl transferase, family 2
GT348_RS00690	COG0783	Belongs to the Dps family
GT348_RS00695	COG1216	Glycosyl transferase, family 2
GT348_RS00695	COG0438	transferase activity, transferring glycosyl groups
GT348_RS00705	COG0581	inorganic phosphate transmembrane transporter activity
GT348_RS00710	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GT348_RS00725	COG0741	lytic transglycosylase activity
GT348_RS00730	COG1309	transcriptional regulator
GT348_RS00735	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GT348_RS00745	COG1538	Outer membrane efflux protein
GT348_RS00770	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GT348_RS00780	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GT348_RS00785	COG2945	thiolester hydrolase activity
GT348_RS00800	COG0482	sulfurtransferase activity
GT348_RS00810	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
GT348_RS00810	COG0506	proline dehydrogenase activity
GT348_RS00810	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
GT348_RS00815	COG0583	DNA-binding transcription factor activity
GT348_RS00820	COG0450	alkyl hydroperoxide reductase
GT348_RS00840	COG2995	paraquat-inducible protein a
GT348_RS00845	COG3008	intermembrane lipid transfer
GT348_RS00865	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GT348_RS00880	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GT348_RS00885	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GT348_RS00890	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GT348_RS00895	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GT348_RS00900	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GT348_RS00965	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
GT348_RS00970	COG1686	Belongs to the peptidase S11 family
GT348_RS00995	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GT348_RS01000	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GT348_RS01020	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GT348_RS01025	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GT348_RS01030	COG0539	negative regulation of cytoplasmic translation
GT348_RS01040	COG1216	Glycosyl transferase, family 2
GT348_RS01050	COG0612	Peptidase, M16
GT348_RS01060	COG1216	Glycosyl transferase, family 2
GT348_RS01075	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GT348_RS01095	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GT348_RS01100	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GT348_RS01115	COG0745	RESPONSE REGULATOR receiver
GT348_RS01120	COG2205	protein histidine kinase activity
GT348_RS01130	COG2814	Major facilitator Superfamily
GT348_RS01145	COG3264	Mechanosensitive ion channel
GT348_RS01145	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
GT348_RS01175	COG2204	response regulator
GT348_RS01185	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GT348_RS01205	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GT348_RS01210	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GT348_RS01215	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GT348_RS01240	COG2983	Belongs to the UPF0260 family
GT348_RS01265	COG1566	PFAM secretion protein HlyD family protein
GT348_RS01290	COG3104	oligopeptide transport
GT348_RS01295	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GT348_RS01315	COG0802	atpase or kinase
GT348_RS01350	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GT348_RS01355	COG3394	polysaccharide catabolic process
GT348_RS01375	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GT348_RS01380	COG1253	flavin adenine dinucleotide binding
GT348_RS01385	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GT348_RS01395	COG1393	Belongs to the ArsC family
GT348_RS01400	COG1113	amino acid transport
GT348_RS01425	COG0126	phosphoglycerate kinase activity
GT348_RS01430	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GT348_RS01435	COG0564	pseudouridine synthase activity
GT348_RS01445	COG0640	Transcriptional regulator
GT348_RS01450	COG1902	pentaerythritol trinitrate reductase activity
GT348_RS01455	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GT348_RS01480	COG1368	sulfuric ester hydrolase activity
GT348_RS01485	COG1596	polysaccharide export
GT348_RS01540	COG2076	Multidrug Resistance protein
GT348_RS01550	COG0656	L-ascorbic acid biosynthetic process
GT348_RS01575	COG2885	chlorophyll binding
GT348_RS01575	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
GT348_RS01585	COG0793	Belongs to the peptidase S41A family
GT348_RS01595	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GT348_RS01600	COG0758	DNA mediated transformation
GT348_RS01605	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GT348_RS01610	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GT348_RS01615	COG0540	Belongs to the ATCase OTCase family
GT348_RS01620	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GT348_RS01630	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GT348_RS01635	COG1132	(ABC) transporter
GT348_RS01645	COG0019	diaminopimelate decarboxylase activity
GT348_RS01650	COG1295	ribonuclease BN
GT348_RS01655	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GT348_RS01660	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GT348_RS01670	COG0439	Biotin carboxylase
GT348_RS01690	COG0765	amino acid transport
GT348_RS01710	COG0542	response to heat
GT348_RS01720	COG0779	Required for maturation of 30S ribosomal subunits
GT348_RS01735	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GT348_RS01740	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GT348_RS01745	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GT348_RS01750	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GT348_RS01755	COG1185	polyribonucleotide nucleotidyltransferase activity
GT348_RS01770	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GT348_RS01775	COG3158	transport of potassium into the cell
GT348_RS01780	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GT348_RS01810	COG0667	Aldo Keto reductase
GT348_RS01835	COG1203	CRISPR-associated helicase, Cas3
GT348_RS01850	COG1857	crispr-associated protein
GT348_RS01870	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GT348_RS01895	COG1028	Short-chain dehydrogenase reductase Sdr
GT348_RS01905	COG2376	Dihydroxyacetone kinase
GT348_RS01910	COG0698	ribose 5-phosphate isomerase
GT348_RS01930	COG0523	cobalamin synthesis protein
GT348_RS01970	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
GT348_RS01980	COG0156	8-amino-7-oxononanoate synthase activity
GT348_RS02000	COG0140	phosphoribosyl-ATP diphosphatase activity
GT348_RS02010	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GT348_RS02015	COG2814	Major facilitator Superfamily
GT348_RS02020	COG0114	fumarate hydratase activity
GT348_RS02025	COG0281	malic enzyme
GT348_RS02035	COG3088	subunit of a heme lyase
GT348_RS02040	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GT348_RS02050	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
GT348_RS02075	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
GT348_RS02085	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GT348_RS02095	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GT348_RS02120	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GT348_RS02120	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GT348_RS02125	COG2967	ApaG domain
GT348_RS02155	COG1252	NADH dehydrogenase
GT348_RS02165	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GT348_RS02170	COG0653	protein targeting
GT348_RS02175	COG0217	transcriptional regulatory protein
GT348_RS02180	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
GT348_RS02185	COG0632	four-way junction helicase activity
GT348_RS02195	COG0824	Thioesterase
GT348_RS02205	COG0848	biopolymer transport protein
GT348_RS02220	COG2885	chlorophyll binding
GT348_RS02230	COG0037	tRNA processing
GT348_RS02240	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GT348_RS02245	COG0745	RESPONSE REGULATOR receiver
GT348_RS02260	COG2309	aminopeptidase activity
GT348_RS02270	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GT348_RS02285	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GT348_RS02290	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
GT348_RS02295	COG0561	phosphatase activity
GT348_RS02300	COG0363	glucosamine-6-phosphate deaminase activity
GT348_RS02305	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
GT348_RS02310	COG3265	gluconokinase activity
GT348_RS02325	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GT348_RS02330	COG0697	spore germination
GT348_RS02335	COG0371	Dehydrogenase
GT348_RS02340	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GT348_RS02345	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GT348_RS02355	COG1028	Short-chain dehydrogenase reductase Sdr
GT348_RS02360	COG2423	ornithine cyclodeaminase activity
GT348_RS02405	COG1570	exodeoxyribonuclease VII activity
GT348_RS02415	COG1530	ribonuclease E activity
GT348_RS02420	COG0860	N-Acetylmuramoyl-L-alanine amidase
GT348_RS02425	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GT348_RS02430	COG0730	response to heat
GT348_RS02450	COG0768	penicillin binding
GT348_RS02455	COG0772	Belongs to the SEDS family
GT348_RS02465	COG0751	glycine-tRNA ligase activity
GT348_RS02470	COG0752	glycyl-tRNA synthetase alpha subunit
GT348_RS02485	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GT348_RS02495	COG0316	Belongs to the HesB IscA family
GT348_RS02500	COG0232	Belongs to the dGTPase family. Type 2 subfamily
GT348_RS02505	COG0018	arginyl-trna synthetase
GT348_RS02520	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GT348_RS02530	COG0805	protein transport
GT348_RS02535	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GT348_RS02560	COG1289	transmembrane transporter activity
GT348_RS02580	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
GT348_RS02595	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GT348_RS02605	COG0215	cysteine-tRNA ligase activity
GT348_RS02615	COG2814	Major facilitator Superfamily
GT348_RS02620	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GT348_RS02625	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
GT348_RS02640	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GT348_RS02650	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
GT348_RS02650	COG2885	chlorophyll binding
GT348_RS02655	COG2885	chlorophyll binding
GT348_RS02655	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
GT348_RS02660	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GT348_RS02675	COG0825	malonyl-CoA metabolic process
GT348_RS02690	COG0494	nUDIX hydrolase
GT348_RS02705	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GT348_RS02720	COG1758	RNA polymerase activity
GT348_RS02730	COG0736	holo-[acyl-carrier-protein] synthase activity
GT348_RS02735	COG0681	Belongs to the peptidase S26 family
GT348_RS02745	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GT348_RS02750	COG0528	UMP kinase activity
GT348_RS02755	COG0233	cytoplasmic translational termination
GT348_RS02760	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GT348_RS02765	COG0575	Belongs to the CDS family
GT348_RS02780	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GT348_RS02790	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
GT348_RS02795	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GT348_RS02805	COG3494	Protein of unknown function (DUF1009)
GT348_RS02810	COG0346	lactoylglutathione lyase activity
GT348_RS02820	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GT348_RS02825	COG0594	ribonuclease P activity
GT348_RS02830	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GT348_RS02835	COG0706	membrane insertase activity
GT348_RS02840	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GT348_RS02855	COG2171	N-acyltransferase activity
GT348_RS02860	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GT348_RS02865	COG0101	tRNA pseudouridine synthase activity
GT348_RS02870	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GT348_RS02875	COG0242	peptide deformylase activity
GT348_RS02890	COG1137	ATPase activity
GT348_RS02905	COG0517	IMP dehydrogenase activity
GT348_RS02905	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GT348_RS02935	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
GT348_RS02945	COG0556	nucleotide-excision repair
GT348_RS02960	COG0189	ligase activity
GT348_RS02975	COG0109	protoheme IX farnesyltransferase activity
GT348_RS02990	COG0312	modulator of DNA gyrase
GT348_RS02995	COG0612	Peptidase, M16
GT348_RS03010	COG0457	Tetratricopeptide repeat
GT348_RS03010	COG0859	PFAM glycosyl transferase family 9
GT348_RS03035	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
GT348_RS03040	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GT348_RS03050	COG0386	Belongs to the glutathione peroxidase family
GT348_RS03055	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GT348_RS03060	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GT348_RS03065	COG0181	hydroxymethylbilane synthase activity
GT348_RS03075	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
GT348_RS03085	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
GT348_RS03110	COG1120	ATPase activity
GT348_RS03120	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
GT348_RS03125	COG0412	Dienelactone hydrolase
GT348_RS03130	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GT348_RS03135	COG0459	protein refolding
GT348_RS03150	COG0392	lysyltransferase activity
GT348_RS03160	COG0670	Belongs to the BI1 family
GT348_RS03180	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
GT348_RS03200	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GT348_RS03220	COG0628	permease
GT348_RS03225	COG0488	(ABC) transporter
GT348_RS03230	COG0105	UTP biosynthetic process
GT348_RS03235	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GT348_RS03240	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GT348_RS03245	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GT348_RS03250	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
GT348_RS03255	COG0248	Ppx GppA phosphatase
GT348_RS03265	COG0019	diaminopimelate decarboxylase activity
GT348_RS03290	COG0519	Catalyzes the synthesis of GMP from XMP
GT348_RS03290	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GT348_RS03305	COG0469	pyruvate kinase activity
GT348_RS03310	COG0287	Prephenate dehydrogenase
GT348_RS03320	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GT348_RS03325	COG1215	transferase activity, transferring glycosyl groups
GT348_RS03330	COG1562	ergosterol biosynthetic process
GT348_RS03335	COG1562	ergosterol biosynthetic process
GT348_RS03340	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
GT348_RS03345	COG1657	PFAM Prenyltransferase squalene oxidase
GT348_RS03350	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GT348_RS03355	COG0052	Belongs to the universal ribosomal protein uS2 family
GT348_RS03360	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GT348_RS03365	COG1381	Involved in DNA repair and RecF pathway recombination
GT348_RS03375	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GT348_RS03390	COG0626	cystathionine gamma-synthase activity
GT348_RS03395	COG0436	Aminotransferase
GT348_RS03405	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GT348_RS03415	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
GT348_RS03420	COG1605	Chorismate mutase
GT348_RS03420	COG0077	Prephenate dehydratase
GT348_RS03425	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GT348_RS03430	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GT348_RS03440	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GT348_RS03445	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GT348_RS03455	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GT348_RS03455	COG1017	nitric oxide dioxygenase activity
GT348_RS03460	COG1959	2 iron, 2 sulfur cluster binding
GT348_RS03495	COG0745	RESPONSE REGULATOR receiver
GT348_RS03500	COG0708	Exodeoxyribonuclease III
GT348_RS03510	COG0322	excinuclease ABC activity
GT348_RS03525	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GT348_RS03535	COG0148	phosphopyruvate hydratase activity
GT348_RS03555	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GT348_RS03560	COG0149	triose-phosphate isomerase activity
GT348_RS03570	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GT348_RS03575	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GT348_RS03580	COG0134	indole-3-glycerol-phosphate synthase activity
GT348_RS03585	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GT348_RS03590	COG0508	dehydrogenase complex catalyzes the overall conversion of
GT348_RS03590	COG0022	dehydrogenase e1 component
GT348_RS03595	COG0508	dehydrogenase complex catalyzes the overall conversion of
GT348_RS03600	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GT348_RS03605	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GT348_RS03610	COG2867	negative regulation of translational initiation
GT348_RS03645	COG0626	cystathionine gamma-synthase activity
GT348_RS03660	COG0741	lytic transglycosylase activity
GT348_RS03665	COG0861	Integral membrane protein TerC family
GT348_RS03670	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GT348_RS03675	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GT348_RS03680	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GT348_RS03690	COG0047	phosphoribosylformylglycinamidine synthase activity
GT348_RS03695	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GT348_RS03705	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
GT348_RS03715	COG0792	nuclease activity
GT348_RS03720	COG0113	porphobilinogen synthase activity
GT348_RS03725	COG0531	amino acid
GT348_RS03730	COG0531	amino acid
GT348_RS03735	COG0531	amino acid
GT348_RS03740	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GT348_RS03745	COG0513	Belongs to the DEAD box helicase family
GT348_RS03805	COG4774	siderophore transport
GT348_RS03830	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GT348_RS03835	COG2814	Major facilitator Superfamily
GT348_RS03845	COG1271	oxidase subunit
GT348_RS03850	COG1294	oxidase, subunit
GT348_RS03890	COG0284	orotidine-5'-phosphate decarboxylase activity
GT348_RS03910	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
GT348_RS03915	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
GT348_RS03930	COG0006	proline dipeptidase activity
GT348_RS03935	COG2264	protein methyltransferase activity
GT348_RS03945	COG2003	Belongs to the UPF0758 family
GT348_RS03950	COG2003	Belongs to the UPF0758 family
GT348_RS03955	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GT348_RS03975	COG0254	rRNA binding
GT348_RS03980	COG1970	mechanosensitive ion channel activity
GT348_RS03995	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GT348_RS04000	COG0673	inositol 2-dehydrogenase activity
GT348_RS04010	COG4988	ABC transporter
GT348_RS04015	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GT348_RS04035	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GT348_RS04040	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GT348_RS04045	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GT348_RS04060	COG0837	glucose binding
GT348_RS04070	COG1070	Carbohydrate kinase
GT348_RS04080	COG0673	inositol 2-dehydrogenase activity
GT348_RS04085	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GT348_RS04090	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GT348_RS04095	COG0154	amidase activity
GT348_RS04100	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GT348_RS04125	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GT348_RS04140	COG0525	valine-tRNA ligase activity
GT348_RS04145	COG0129	dihydroxy-acid dehydratase activity
GT348_RS04150	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GT348_RS04165	COG0756	dUTP diphosphatase activity
GT348_RS04170	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GT348_RS04175	COG2226	methyltransferase
GT348_RS04180	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GT348_RS04185	COG0268	Binds directly to 16S ribosomal RNA
GT348_RS04190	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GT348_RS04195	COG0592	DNA-directed DNA polymerase activity
GT348_RS04200	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GT348_RS04220	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GT348_RS04240	COG2223	nitrite transmembrane transporter activity
GT348_RS04275	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GT348_RS04280	COG0318	PFAM AMP-dependent synthetase and ligase
GT348_RS04350	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GT348_RS04355	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GT348_RS04360	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GT348_RS04365	COG1028	Short-chain dehydrogenase reductase Sdr
GT348_RS04370	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GT348_RS04380	COG3590	peptidase
GT348_RS04390	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GT348_RS04425	COG0354	folic acid binding
GT348_RS04430	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GT348_RS04435	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
GT348_RS04440	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
GT348_RS04445	COG3781	membrane
GT348_RS04450	COG1329	Transcriptional regulator
GT348_RS04470	COG0729	surface antigen
GT348_RS04480	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GT348_RS04490	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GT348_RS04495	COG1253	flavin adenine dinucleotide binding
GT348_RS04505	COG1196	nuclear chromosome segregation
GT348_RS04545	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GT348_RS04555	COG0142	geranyltranstransferase activity
GT348_RS04570	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GT348_RS04575	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GT348_RS04580	COG0259	pyridoxamine-phosphate oxidase activity
GT348_RS04590	COG1519	Transferase
GT348_RS04620	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GT348_RS04630	COG3572	ergothioneine biosynthetic process
GT348_RS04645	COG2814	Major facilitator Superfamily
GT348_RS04655	COG1160	GTP binding
GT348_RS04685	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GT348_RS04690	COG0237	dephospho-CoA kinase activity
GT348_RS04695	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GT348_RS04705	COG0165	Argininosuccinate lyase
GT348_RS04715	COG1234	tRNA 3'-trailer cleavage
GT348_RS04720	COG0084	hydrolase, TatD family'
GT348_RS04725	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GT348_RS04735	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GT348_RS04740	COG1686	Belongs to the peptidase S11 family
GT348_RS04745	COG2951	lytic endotransglycosylase activity
GT348_RS04760	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
GT348_RS04765	COG1968	undecaprenyl-diphosphatase activity
GT348_RS04770	COG0531	amino acid
GT348_RS04785	COG2890	protein-(glutamine-N5) methyltransferase activity
GT348_RS04795	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GT348_RS04800	COG0124	histidyl-tRNA synthetase
GT348_RS04805	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GT348_RS04815	COG2070	2-Nitropropane dioxygenase
GT348_RS04820	COG0527	aspartate kinase activity
GT348_RS04825	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GT348_RS04830	COG2706	6-phosphogluconolactonase activity
GT348_RS04840	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GT348_RS04845	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GT348_RS04865	COG0321	lipoyl(octanoyl) transferase activity
GT348_RS04880	COG0484	heat shock protein binding
GT348_RS04900	COG0587	DNA-directed DNA polymerase activity
GT348_RS04910	COG1136	(ABC) transporter
GT348_RS04920	COG0442	prolyl-tRNA aminoacylation
GT348_RS04960	COG0740	serine-type endopeptidase activity
GT348_RS04965	COG0544	peptidyl-prolyl cis-trans isomerase activity
GT348_RS04975	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GT348_RS04975	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
GT348_RS04985	COG0513	Belongs to the DEAD box helicase family
GT348_RS04990	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GT348_RS05000	COG2151	metal-sulfur cluster biosynthetic enzyme
GT348_RS05010	COG0719	Fe-S assembly protein
GT348_RS05015	COG0396	ATPase activity
GT348_RS05030	COG2733	membrane
GT348_RS05050	COG0038	chloride channel
GT348_RS05055	COG0038	chloride channel
GT348_RS05060	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GT348_RS05065	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GT348_RS05070	COG5265	(ABC) transporter
GT348_RS05080	COG0628	permease
GT348_RS05095	COG0776	regulation of translation
GT348_RS05100	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GT348_RS05110	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GT348_RS05125	COG1846	Transcriptional regulator
GT348_RS05130	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GT348_RS05150	COG0583	DNA-binding transcription factor activity
GT348_RS05155	COG0776	regulation of translation
GT348_RS05160	COG4957	zinc ion binding
GT348_RS05165	COG1573	uracil-dna glycosylase
GT348_RS05170	COG1289	transmembrane transporter activity
GT348_RS05185	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GT348_RS05190	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GT348_RS05195	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GT348_RS05205	COG1139	Iron-sulfur cluster binding protein
GT348_RS05235	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GT348_RS05250	COG2001	Belongs to the MraZ family
GT348_RS05255	COG0275	rRNA processing
GT348_RS05280	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GT348_RS05285	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GT348_RS05300	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GT348_RS05305	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GT348_RS05310	COG1181	Belongs to the D-alanine--D-alanine ligase family
GT348_RS05315	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GT348_RS05325	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GT348_RS05335	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GT348_RS05340	COG0497	DNA recombination
GT348_RS05345	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GT348_RS05350	COG1253	flavin adenine dinucleotide binding
GT348_RS05355	COG1335	isochorismatase
GT348_RS05405	COG0328	RNA-DNA hybrid ribonuclease activity
GT348_RS05410	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GT348_RS05415	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GT348_RS05470	COG0473	3-isopropylmalate dehydrogenase activity
GT348_RS05475	COG0066	3-isopropylmalate dehydratase activity
GT348_RS05480	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GT348_RS05485	COG0335	large ribosomal subunit rRNA binding
GT348_RS05490	COG0336	Belongs to the RNA methyltransferase TrmD family
GT348_RS05500	COG0228	four-way junction DNA binding
GT348_RS05520	COG0513	Belongs to the DEAD box helicase family
GT348_RS05525	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GT348_RS05525	COG2813	Specifically methylates the guanine in position
GT348_RS05530	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
GT348_RS05540	COG0778	Nitroreductase
GT348_RS05575	COG1692	metallophosphoesterase
GT348_RS05580	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GT348_RS05620	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
GT348_RS05625	COG1509	lysine 2,3-aminomutase activity
GT348_RS05630	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GT348_RS05635	COG0483	inositol monophosphate 1-phosphatase activity
GT348_RS05655	COG0481	GTPase activity
GT348_RS05665	COG2252	PERMEase
GT348_RS05670	COG1722	exodeoxyribonuclease VII activity
GT348_RS05675	COG0142	geranyltranstransferase activity
GT348_RS05680	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GT348_RS05685	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
GT348_RS05690	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GT348_RS05695	COG0137	argininosuccinate synthase activity
GT348_RS05700	COG0545	Peptidyl-prolyl cis-trans isomerase
GT348_RS05705	COG0180	Tryptophanyl-tRNA synthetase
GT348_RS05715	COG0072	phenylalanine-tRNA ligase activity
GT348_RS05715	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GT348_RS05720	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GT348_RS05725	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GT348_RS05730	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GT348_RS05735	COG4993	Dehydrogenase
GT348_RS05750	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GT348_RS05755	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GT348_RS05765	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GT348_RS05765	COG4191	Histidine kinase
GT348_RS05775	COG1136	(ABC) transporter
GT348_RS05775	COG0577	efflux transmembrane transporter activity
GT348_RS05815	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GT348_RS05830	COG0688	phosphatidylethanolamine metabolic process
GT348_RS05835	COG1183	phosphatidylcholine synthase activity
GT348_RS05840	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
GT348_RS05875	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GT348_RS05880	COG1218	3'(2'),5'-bisphosphate nucleotidase
GT348_RS05885	COG0009	L-threonylcarbamoyladenylate synthase
GT348_RS05915	COG2942	2-epimerase
GT348_RS05920	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GT348_RS05920	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
GT348_RS05935	COG0795	lipopolysaccharide-transporting ATPase activity
GT348_RS05955	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GT348_RS05960	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GT348_RS05965	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
GT348_RS05970	COG0359	binds to the 23S rRNA
GT348_RS05975	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GT348_RS05980	COG0360	Binds together with S18 to 16S ribosomal RNA
GT348_RS05995	COG0697	spore germination
GT348_RS06005	COG0505	Belongs to the CarA family
GT348_RS06010	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GT348_RS06015	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GT348_RS06020	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GT348_RS06025	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
GT348_RS06030	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
GT348_RS06040	COG1012	belongs to the aldehyde dehydrogenase family
GT348_RS06045	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GT348_RS06070	COG0793	Belongs to the peptidase S41A family
GT348_RS06075	COG0494	nUDIX hydrolase
GT348_RS06080	COG1132	(ABC) transporter
GT348_RS06085	COG0617	tRNA 3'-terminal CCA addition
GT348_RS06125	COG2189	Belongs to the N(4) N(6)-methyltransferase family
GT348_RS06130	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GT348_RS06155	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GT348_RS06160	COG1538	Outer membrane efflux protein
GT348_RS06170	COG0203	ribosomal protein L17
GT348_RS06175	COG0202	RNA polymerase activity
GT348_RS06180	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GT348_RS06185	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GT348_RS06190	COG0563	adenylate kinase activity
GT348_RS06200	COG0200	Binds to the 23S rRNA
GT348_RS06205	COG1841	ribosomal large subunit assembly
GT348_RS06210	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GT348_RS06215	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GT348_RS06220	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GT348_RS06225	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GT348_RS06230	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GT348_RS06235	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GT348_RS06240	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
GT348_RS06245	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GT348_RS06250	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GT348_RS06255	COG0255	Belongs to the universal ribosomal protein uL29 family
GT348_RS06260	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GT348_RS06265	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GT348_RS06270	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GT348_RS06275	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GT348_RS06280	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GT348_RS06285	COG0089	rRNA binding
GT348_RS06290	COG0088	Forms part of the polypeptide exit tunnel
GT348_RS06295	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GT348_RS06300	COG0051	transcription antitermination factor activity, RNA binding
GT348_RS06305	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GT348_RS06310	COG0049	tRNA binding
GT348_RS06315	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GT348_RS06320	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GT348_RS06330	COG0222	ribosome binding
GT348_RS06335	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GT348_RS06340	COG0081	regulation of translation
GT348_RS06345	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GT348_RS06350	COG1538	Outer membrane efflux protein
GT348_RS06375	COG1322	Protein conserved in bacteria
GT348_RS06390	COG0850	regulation of cytokinetic process
GT348_RS06400	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
GT348_RS06405	COG3128	pkhd-type hydroxylase
GT348_RS06420	COG0495	leucyl-tRNA aminoacylation
GT348_RS06430	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GT348_RS06435	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GT348_RS06450	COG0138	bifunctional purine biosynthesis protein purh
GT348_RS06470	COG0800	Aldolase
GT348_RS06475	COG0129	dihydroxy-acid dehydratase activity
GT348_RS06480	COG0741	lytic transglycosylase activity
GT348_RS06500	COG1742	UPF0060 membrane protein
GT348_RS06505	COG0004	ammonium transporteR
GT348_RS06520	COG1045	serine acetyltransferase
GT348_RS06525	COG2017	converts alpha-aldose to the beta-anomer
GT348_RS06540	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GT348_RS06545	COG0343	queuine tRNA-ribosyltransferase activity
GT348_RS06555	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GT348_RS06565	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
GT348_RS06590	COG0693	protein deglycase activity
GT348_RS06610	COG1309	transcriptional regulator
GT348_RS06615	COG2814	Major facilitator Superfamily
GT348_RS06625	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GT348_RS06645	COG1309	transcriptional regulator
GT348_RS06660	COG4774	siderophore transport
GT348_RS06665	COG3128	pkhd-type hydroxylase
GT348_RS06675	COG0848	biopolymer transport protein
GT348_RS06685	COG0590	tRNA wobble adenosine to inosine editing
GT348_RS06690	COG1187	pseudouridine synthase activity
GT348_RS06695	COG0742	ribosomal rna small subunit methyltransferase
GT348_RS06715	COG0778	Nitroreductase
GT348_RS06720	COG0131	Imidazoleglycerol-phosphate dehydratase
GT348_RS06725	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GT348_RS06730	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GT348_RS06735	COG0107	imidazoleglycerol-phosphate synthase activity
GT348_RS06740	COG0140	phosphoribosyl-ATP diphosphatase activity
GT348_RS06765	COG0753	catalase activity
GT348_RS06780	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GT348_RS06820	COG0723	plastoquinol--plastocyanin reductase activity
GT348_RS06825	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GT348_RS06835	COG0667	Aldo Keto reductase
GT348_RS06840	COG0745	RESPONSE REGULATOR receiver
GT348_RS06865	COG1643	Atp-dependent helicase
GT348_RS06875	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GT348_RS06900	COG2814	Major facilitator Superfamily
GT348_RS06910	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GT348_RS06915	COG0717	Belongs to the dCTP deaminase family
GT348_RS06925	COG0438	transferase activity, transferring glycosyl groups
GT348_RS06935	COG0443	Heat shock 70 kDa protein
GT348_RS06940	COG0484	heat shock protein binding
GT348_RS06945	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GT348_RS06950	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GT348_RS06955	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GT348_RS06965	COG2086	electron transfer activity
GT348_RS06985	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GT348_RS06990	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GT348_RS07010	COG0159	tryptophan synthase activity
GT348_RS07020	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GT348_RS07030	COG0305	Participates in initiation and elongation during chromosome replication
GT348_RS07035	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GT348_RS07040	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GT348_RS07065	COG2801	Transposase and inactivated derivatives
GT348_RS07070	COG2842	Transposition protein
GT348_RS07120	COG4373	Mu-like prophage FluMu protein gp28
GT348_RS07215	COG4397	Mu-like prophage major head subunit gpT
GT348_RS07240	COG4386	tail sheath protein
GT348_RS07330	COG1902	pentaerythritol trinitrate reductase activity
GT348_RS07335	COG1733	regulation of RNA biosynthetic process
GT348_RS07365	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GT348_RS07365	COG2010	Cytochrome c
GT348_RS07370	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
GT348_RS07410	COG0668	transmembrane transport
GT348_RS07425	COG1464	Belongs to the NlpA lipoprotein family
GT348_RS07460	COG0363	glucosamine-6-phosphate deaminase activity
GT348_RS07475	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GT348_RS07480	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GT348_RS07485	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GT348_RS07495	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GT348_RS07510	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GT348_RS07530	COG2329	Antibiotic biosynthesis monooxygenase
GT348_RS07570	COG0753	catalase activity
GT348_RS07590	COG0602	queuosine metabolic process
GT348_RS07595	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GT348_RS07610	COG0602	queuosine metabolic process
GT348_RS07615	COG0302	gtp cyclohydrolase
GT348_RS07620	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GT348_RS07620	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GT348_RS07625	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GT348_RS07630	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
GT348_RS07630	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GT348_RS07635	COG0405	Gamma-glutamyltransferase
GT348_RS07640	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GT348_RS07650	COG0740	serine-type endopeptidase activity
GT348_RS07670	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GT348_RS07750	COG0252	asparaginase activity
GT348_RS07760	COG2985	domain, Protein
GT348_RS07805	COG0463	Glycosyl transferase, family 2
GT348_RS07810	COG2814	Major facilitator Superfamily
GT348_RS07815	COG0246	Mannitol dehydrogenase
GT348_RS07820	COG2323	membrane
GT348_RS07835	COG0629	single-stranded DNA binding
GT348_RS07865	COG3300	MHYT domain
GT348_RS07865	COG5001	Diguanylate cyclase
GT348_RS07885	COG0604	alcohol dehydrogenase
GT348_RS07885	COG1028	Short-chain dehydrogenase reductase Sdr
GT348_RS07885	COG3321	synthase
GT348_RS07890	COG0318	PFAM AMP-dependent synthetase and ligase
GT348_RS07915	COG4232	protein-disulfide reductase activity
GT348_RS07965	COG0175	sulfate reduction
GT348_RS07970	COG0175	sulfate reduction
GT348_RS07980	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
GT348_RS07985	COG1127	ABC transporter
GT348_RS08005	COG1914	H( )-stimulated, divalent metal cation uptake system
GT348_RS08050	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GT348_RS08060	COG2207	Transcriptional regulator
GT348_RS08065	COG2217	Heavy metal translocating P-type atpase
GT348_RS08075	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GT348_RS08080	COG0194	GDP metabolic process
GT348_RS08090	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
GT348_RS08095	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
GT348_RS08105	COG0535	radical SAM domain protein
GT348_RS08110	COG1442	glycosyl transferase family 8
GT348_RS08120	COG1442	glycosyl transferase family 8
GT348_RS08125	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GT348_RS08130	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GT348_RS08130	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GT348_RS08135	COG0307	riboflavin synthase, alpha
GT348_RS08140	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GT348_RS08140	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GT348_RS08150	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GT348_RS08155	COG3047	cAMP biosynthetic process
GT348_RS08170	COG1538	Outer membrane efflux protein
GT348_RS08180	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GT348_RS08200	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GT348_RS08205	COG0424	maF-like protein
GT348_RS08215	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
GT348_RS08225	COG0656	L-ascorbic acid biosynthetic process
GT348_RS08260	COG0420	3'-5' exonuclease activity
GT348_RS08265	COG4717	serine-type aminopeptidase activity
GT348_RS08275	COG0326	Molecular chaperone. Has ATPase activity
GT348_RS08285	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GT348_RS08300	COG1028	Short-chain dehydrogenase reductase Sdr
GT348_RS08335	COG3210	domain, Protein
GT348_RS08405	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GT348_RS08410	COG0424	maF-like protein
GT348_RS08425	COG3842	ATPase activity
GT348_RS08435	COG1091	dTDP-4-dehydrorhamnose reductase activity
GT348_RS08440	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
GT348_RS08460	COG2244	polysaccharide biosynthetic process
GT348_RS08470	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GT348_RS08475	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GT348_RS08485	COG1475	DNA binding
GT348_RS08490	COG1192	Involved in chromosome partitioning
GT348_RS08495	COG0357	Ribosomal RNA small subunit methyltransferase G
GT348_RS08500	COG0445	tRNA wobble uridine modification
GT348_RS08505	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GT348_RS08510	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GT348_RS08515	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GT348_RS08520	COG0508	dehydrogenase complex catalyzes the overall conversion of
GT348_RS08530	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
GT348_RS08550	COG1194	a g-specific adenine glycosylase
GT348_RS08560	COG0560	Phosphoserine phosphatase
GT348_RS08565	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GT348_RS08575	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GT348_RS08580	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
GT348_RS08585	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
GT348_RS08590	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GT348_RS08600	COG0509	glycine decarboxylation via glycine cleavage system
GT348_RS08605	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GT348_RS08605	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GT348_RS08615	COG1940	carbohydrate kinase activity
GT348_RS08625	COG0312	modulator of DNA gyrase
GT348_RS08655	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GT348_RS08660	COG0463	Glycosyl transferase, family 2
GT348_RS08665	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GT348_RS08670	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GT348_RS08675	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GT348_RS08680	COG0356	it plays a direct role in the translocation of protons across the membrane
GT348_RS08780	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GT348_RS08870	COG2943	transferase activity, transferring hexosyl groups
GT348_RS08885	COG4786	Flagellar basal body rod
GT348_RS08890	COG4786	Flagellar basal body rod
GT348_RS08900	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
GT348_RS08920	COG1766	The M ring may be actively involved in energy transduction
GT348_RS08925	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GT348_RS08935	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GT348_RS08945	COG1338	Plays a role in the flagellum-specific transport system
GT348_RS08955	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GT348_RS08965	COG1442	glycosyl transferase family 8
GT348_RS08965	COG1216	Glycosyl transferase, family 2
GT348_RS08970	COG1216	Glycosyl transferase, family 2
GT348_RS08980	COG1706	bacterial-type flagellum-dependent cell motility
GT348_RS09010	COG1157	protein secretion by the type III secretion system
GT348_RS09025	COG1360	Flagellar Motor Protein
GT348_RS09030	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GT348_RS09055	COG1749	Flagellar hook protein flgE
GT348_RS09060	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GT348_RS09075	COG1677	Flagellar hook-basal body complex protein FliE
GT348_RS09090	COG1815	bacterial-type flagellum-dependent cell motility
GT348_RS09095	COG1558	bacterial-type flagellum-dependent cell motility
GT348_RS09115	COG1475	DNA binding
GT348_RS09120	COG1192	Involved in chromosome partitioning
GT348_RS09145	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella