locus-tag	class	description
B2B01_RS00005	COG0445	tRNA wobble uridine modification
B2B01_RS00010	COG0357	Ribosomal RNA small subunit methyltransferase G
B2B01_RS00015	COG1192	Involved in chromosome partitioning
B2B01_RS00020	COG1475	DNA binding
B2B01_RS00025	COG0252	asparaginase activity
B2B01_RS00045	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B2B01_RS00055	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
B2B01_RS00065	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
B2B01_RS00070	COG0081	regulation of translation
B2B01_RS00075	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
B2B01_RS00080	COG0222	ribosome binding
B2B01_RS00085	COG0085	RNA polymerase activity
B2B01_RS00090	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
B2B01_RS00120	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
B2B01_RS00125	COG0049	tRNA binding
B2B01_RS00130	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
B2B01_RS00135	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B2B01_RS00140	COG0051	transcription antitermination factor activity, RNA binding
B2B01_RS00145	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
B2B01_RS00150	COG0088	Forms part of the polypeptide exit tunnel
B2B01_RS00155	COG0089	rRNA binding
B2B01_RS00160	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
B2B01_RS00165	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
B2B01_RS00170	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
B2B01_RS00175	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
B2B01_RS00180	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
B2B01_RS00185	COG0255	Belongs to the universal ribosomal protein uL29 family
B2B01_RS00190	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
B2B01_RS00200	COG0179	Fumarylacetoacetate (FAA) hydrolase
B2B01_RS00205	COG3181	Tripartite tricarboxylate transporter family receptor
B2B01_RS00240	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
B2B01_RS00245	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
B2B01_RS00250	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
B2B01_RS00255	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
B2B01_RS00260	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
B2B01_RS00265	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
B2B01_RS00270	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
B2B01_RS00275	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
B2B01_RS00280	COG1841	ribosomal large subunit assembly
B2B01_RS00285	COG0200	Binds to the 23S rRNA
B2B01_RS00290	COG0201	protein transport
B2B01_RS00295	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
B2B01_RS00300	COG0257	Belongs to the bacterial ribosomal protein bL36 family
B2B01_RS00305	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
B2B01_RS00310	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
B2B01_RS00315	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
B2B01_RS00320	COG0202	RNA polymerase activity
B2B01_RS00325	COG0203	ribosomal protein L17
B2B01_RS00335	COG1324	tolerance protein
B2B01_RS00340	COG4232	protein-disulfide reductase activity
B2B01_RS00350	COG0218	Necessary for normal cell division and for the maintenance of normal septation
B2B01_RS00360	COG1333	cytochrome c biogenesis protein
B2B01_RS00365	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B2B01_RS00380	COG1965	Belongs to the frataxin family
B2B01_RS00390	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
B2B01_RS00395	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
B2B01_RS00400	COG0232	Belongs to the dGTPase family. Type 2 subfamily
B2B01_RS00420	COG2814	Major facilitator Superfamily
B2B01_RS00425	COG0629	single-stranded DNA binding
B2B01_RS00475	COG1086	Polysaccharide biosynthesis protein
B2B01_RS00485	COG0438	transferase activity, transferring glycosyl groups
B2B01_RS00490	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
B2B01_RS00495	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
B2B01_RS00525	COG0642	Histidine kinase
B2B01_RS00530	COG1840	ABC-type Fe3 transport system, periplasmic component
B2B01_RS00535	COG1175	transmembrane transport
B2B01_RS00540	COG3842	ATPase activity
B2B01_RS00550	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
B2B01_RS00560	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
B2B01_RS00565	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B2B01_RS00570	COG1956	GAF domain-containing protein
B2B01_RS00575	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B2B01_RS00600	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
B2B01_RS00605	COG3568	Endonuclease Exonuclease Phosphatase
B2B01_RS00620	COG2814	Major facilitator Superfamily
B2B01_RS00630	COG3210	domain, Protein
B2B01_RS00630	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
B2B01_RS00630	COG3064	Membrane
B2B01_RS00650	COG0859	PFAM glycosyl transferase family 9
B2B01_RS00665	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
B2B01_RS00675	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
B2B01_RS00680	COG1127	ABC transporter
B2B01_RS00700	COG1686	Belongs to the peptidase S11 family
B2B01_RS00710	COG2921	Belongs to the UPF0250 family
B2B01_RS00715	COG0321	lipoyl(octanoyl) transferase activity
B2B01_RS00720	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
B2B01_RS00725	COG2096	Adenosyltransferase
B2B01_RS00735	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
B2B01_RS00740	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
B2B01_RS00750	COG0523	cobalamin synthesis protein
B2B01_RS00755	COG0735	belongs to the Fur family
B2B01_RS00765	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B2B01_RS00770	COG0803	Belongs to the bacterial solute-binding protein 9 family
B2B01_RS00790	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
B2B01_RS00800	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
B2B01_RS00805	COG1560	Kdo2-lipid A biosynthetic process
B2B01_RS00815	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
B2B01_RS00835	COG1950	PFAM Membrane protein of
B2B01_RS00840	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
B2B01_RS00865	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
B2B01_RS00875	COG0617	tRNA 3'-terminal CCA addition
B2B01_RS00885	COG0513	Belongs to the DEAD box helicase family
B2B01_RS00890	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
B2B01_RS00895	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
B2B01_RS00990	COG3181	Tripartite tricarboxylate transporter family receptor
B2B01_RS00995	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
B2B01_RS01000	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B2B01_RS01005	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B2B01_RS01020	COG0758	DNA mediated transformation
B2B01_RS01025	COG2197	response regulator
B2B01_RS01030	COG1522	sequence-specific DNA binding
B2B01_RS01040	COG0242	peptide deformylase activity
B2B01_RS01045	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
B2B01_RS01055	COG0546	phosphoglycolate phosphatase activity
B2B01_RS01065	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B2B01_RS01070	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B2B01_RS01105	COG2072	flavoprotein involved in K transport
B2B01_RS01110	COG1250	3-hydroxyacyl-CoA dehydrogenase
B2B01_RS01115	COG3181	Tripartite tricarboxylate transporter family receptor
B2B01_RS01120	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
B2B01_RS01130	COG0583	DNA-binding transcription factor activity
B2B01_RS01135	COG2188	Transcriptional regulator
B2B01_RS01160	COG1960	acyl-CoA dehydrogenase activity
B2B01_RS01165	COG1280	lysine exporter protein (LysE YggA)
B2B01_RS01170	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
B2B01_RS01170	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B2B01_RS01185	COG2204	response regulator
B2B01_RS01190	COG0569	domain protein
B2B01_RS01200	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
B2B01_RS01205	COG2226	methyltransferase
B2B01_RS01210	COG1040	competence protein
B2B01_RS01220	COG3181	Tripartite tricarboxylate transporter family receptor
B2B01_RS01225	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
B2B01_RS01230	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
B2B01_RS01235	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
B2B01_RS01245	COG0588	phosphoglycerate mutase activity
B2B01_RS01250	COG4942	peptidase
B2B01_RS01255	COG0793	Belongs to the peptidase S41A family
B2B01_RS01260	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
B2B01_RS01265	COG2186	Transcriptional regulator
B2B01_RS01275	COG0861	Integral membrane protein TerC family
B2B01_RS01280	COG0583	DNA-binding transcription factor activity
B2B01_RS01285	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
B2B01_RS01290	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B2B01_RS01290	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B2B01_RS01310	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
B2B01_RS01315	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
B2B01_RS01320	COG0211	Belongs to the bacterial ribosomal protein bL27 family
B2B01_RS01325	COG0261	This protein binds to 23S rRNA in the presence of protein L20
B2B01_RS01330	COG0142	geranyltranstransferase activity
B2B01_RS01345	COG1028	Short-chain dehydrogenase reductase Sdr
B2B01_RS01350	COG4689	acetoacetate decarboxylase
B2B01_RS01390	COG3501	Rhs element vgr protein
B2B01_RS01415	COG1301	dicarboxylic acid transport
B2B01_RS01455	COG0154	amidase activity
B2B01_RS01460	COG0683	leucine binding
B2B01_RS01465	COG0583	DNA-binding transcription factor activity
B2B01_RS01515	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
B2B01_RS01520	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
B2B01_RS01525	COG2890	protein-(glutamine-N5) methyltransferase activity
B2B01_RS01530	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
B2B01_RS01550	COG0288	reversible hydration of carbon dioxide
B2B01_RS01560	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
B2B01_RS01570	COG4829	muconolactone delta-isomerase
B2B01_RS01575	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
B2B01_RS01590	COG2031	fatty acid transporter
B2B01_RS01595	COG1250	3-hydroxyacyl-CoA dehydrogenase
B2B01_RS01600	COG3539	Fimbrial protein
B2B01_RS01605	COG3539	Fimbrial protein
B2B01_RS01610	COG3539	Fimbrial protein
B2B01_RS01615	COG3539	Fimbrial protein
B2B01_RS01620	COG0129	dihydroxy-acid dehydratase activity
B2B01_RS01630	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
B2B01_RS01635	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
B2B01_RS01645	COG0673	inositol 2-dehydrogenase activity
B2B01_RS01650	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
B2B01_RS01665	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B2B01_RS01670	COG0583	DNA-binding transcription factor activity
B2B01_RS01675	COG0628	permease
B2B01_RS01680	COG5285	phytanoyl-CoA dioxygenase
B2B01_RS01685	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
B2B01_RS01770	COG0531	amino acid
B2B01_RS01775	COG1113	amino acid transport
B2B01_RS01780	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
B2B01_RS01785	COG4943	cyclic-guanylate-specific phosphodiesterase activity
B2B01_RS01795	COG3040	lipid binding
B2B01_RS01805	COG1529	Aldehyde oxidase and xanthine dehydrogenase
B2B01_RS01810	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
B2B01_RS01815	COG3171	Protein conserved in bacteria
B2B01_RS01865	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
B2B01_RS01900	COG2233	PERMEase
B2B01_RS01905	COG0326	Molecular chaperone. Has ATPase activity
B2B01_RS01910	COG0625	glutathione transferase activity
B2B01_RS01925	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B2B01_RS01930	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
B2B01_RS01945	COG0220	tRNA (guanine-N7-)-methyltransferase activity
B2B01_RS01965	COG2423	ornithine cyclodeaminase activity
B2B01_RS01975	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B2B01_RS01985	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
B2B01_RS01995	COG0010	Belongs to the arginase family
B2B01_RS02025	COG2194	sulfuric ester hydrolase activity
B2B01_RS02050	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B2B01_RS02050	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B2B01_RS02060	COG0489	protein tyrosine kinase activity
B2B01_RS02075	COG0717	Belongs to the dCTP deaminase family
B2B01_RS02090	COG1982	Orn Lys Arg decarboxylase major
B2B01_RS02095	COG2081	HI0933 family
B2B01_RS02100	COG1609	Transcriptional regulator
B2B01_RS02105	COG0683	leucine binding
B2B01_RS02110	COG0559	Belongs to the binding-protein-dependent transport system permease family
B2B01_RS02135	COG0371	Dehydrogenase
B2B01_RS02145	COG0404	The glycine cleavage system catalyzes the degradation of glycine
B2B01_RS02150	COG0509	glycine decarboxylation via glycine cleavage system
B2B01_RS02155	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B2B01_RS02155	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B2B01_RS02185	COG4172	Belongs to the ABC transporter superfamily
B2B01_RS02190	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B2B01_RS02195	COG0601	transmembrane transport
B2B01_RS02200	COG0747	negative chemotaxis
B2B01_RS02220	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B2B01_RS02230	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
B2B01_RS02240	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
B2B01_RS02245	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B2B01_RS02250	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
B2B01_RS02265	COG0438	transferase activity, transferring glycosyl groups
B2B01_RS02280	COG0438	transferase activity, transferring glycosyl groups
B2B01_RS02290	COG0166	Belongs to the GPI family
B2B01_RS02305	COG0277	FAD linked oxidase domain protein
B2B01_RS02310	COG0745	RESPONSE REGULATOR receiver
B2B01_RS02315	COG5002	protein histidine kinase activity
B2B01_RS02315	COG5000	phosphorelay sensor kinase activity
B2B01_RS02320	COG2186	Transcriptional regulator
B2B01_RS02325	COG1368	sulfuric ester hydrolase activity
B2B01_RS02335	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
B2B01_RS02350	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B2B01_RS02360	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
B2B01_RS02370	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
B2B01_RS02375	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
B2B01_RS02385	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
B2B01_RS02390	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
B2B01_RS02395	COG0193	aminoacyl-tRNA hydrolase activity
B2B01_RS02405	COG0012	GTP binding
B2B01_RS02420	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
B2B01_RS02430	COG0732	type I restriction modification DNA specificity domain
B2B01_RS02435	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
B2B01_RS02475	COG0387	Pfam Sodium calcium exchanger
B2B01_RS02505	COG3135	benzoate transporter
B2B01_RS02510	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
B2B01_RS02515	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
B2B01_RS02520	COG0742	ribosomal rna small subunit methyltransferase
B2B01_RS02555	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
B2B01_RS02560	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B2B01_RS02565	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
B2B01_RS02570	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
B2B01_RS02580	COG0284	orotidine-5'-phosphate decarboxylase activity
B2B01_RS02585	COG1252	NADH dehydrogenase
B2B01_RS02590	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
B2B01_RS02595	COG1295	ribonuclease BN
B2B01_RS02600	COG0459	protein refolding
B2B01_RS02605	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
B2B01_RS02640	COG2814	Major facilitator Superfamily
B2B01_RS02655	COG1393	Belongs to the ArsC family
B2B01_RS02660	COG0431	NADPH-dependent FMN reductase
B2B01_RS02670	COG3181	Tripartite tricarboxylate transporter family receptor
B2B01_RS02675	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B2B01_RS02715	COG4569	acetaldehyde dehydrogenase (acetylating) activity
B2B01_RS02720	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B2B01_RS02730	COG0477	Major facilitator Superfamily
B2B01_RS02760	COG1028	Short-chain dehydrogenase reductase Sdr
B2B01_RS02775	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B2B01_RS02790	COG0179	Fumarylacetoacetate (FAA) hydrolase
B2B01_RS02825	COG1028	Short-chain dehydrogenase reductase Sdr
B2B01_RS02835	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
B2B01_RS02840	COG1802	Transcriptional regulator
B2B01_RS02845	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
B2B01_RS02850	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B2B01_RS02855	COG1335	isochorismatase
B2B01_RS02860	COG0523	cobalamin synthesis protein
B2B01_RS02940	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B2B01_RS02945	COG1116	anion transmembrane transporter activity
B2B01_RS02970	COG3395	kinase activity
B2B01_RS02975	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
B2B01_RS02990	COG0179	Fumarylacetoacetate (FAA) hydrolase
B2B01_RS03015	COG2146	nitrite reductase [NAD(P)H] activity
B2B01_RS03030	COG3971	2-oxopent-4-enoate hydratase activity
B2B01_RS03065	COG0513	Belongs to the DEAD box helicase family
B2B01_RS03075	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B2B01_RS03080	COG0583	DNA-binding transcription factor activity
B2B01_RS03100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B2B01_RS03105	COG1126	abc transporter atp-binding protein
B2B01_RS03110	COG0765	amino acid transport
B2B01_RS03115	COG0765	amino acid transport
B2B01_RS03120	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B2B01_RS03145	COG1522	sequence-specific DNA binding
B2B01_RS03150	COG4106	trans-aconitate 2-methyltransferase activity
B2B01_RS03155	COG0667	Aldo Keto reductase
B2B01_RS03165	COG2154	pterin-4-alpha-carbinolamine dehydratase
B2B01_RS03175	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
B2B01_RS03185	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
B2B01_RS03190	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B2B01_RS03195	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
B2B01_RS03200	COG1929	Belongs to the glycerate kinase type-1 family
B2B01_RS03210	COG0700	Nucleoside recognition
B2B01_RS03215	COG0242	peptide deformylase activity
B2B01_RS03235	COG0583	DNA-binding transcription factor activity
B2B01_RS03245	COG0204	Acyl-transferase
B2B01_RS03250	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
B2B01_RS03255	COG0751	glycine-tRNA ligase activity
B2B01_RS03260	COG0752	glycyl-tRNA synthetase alpha subunit
B2B01_RS03265	COG1024	Enoyl-CoA hydratase
B2B01_RS03275	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
B2B01_RS03275	COG3210	domain, Protein
B2B01_RS03275	COG3210	domain, Protein
B2B01_RS03275	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
B2B01_RS03275	COG3064	Membrane
B2B01_RS03275	COG3064	Membrane
B2B01_RS03280	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
B2B01_RS03305	COG1335	isochorismatase
B2B01_RS03315	COG0617	tRNA 3'-terminal CCA addition
B2B01_RS03325	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
B2B01_RS03330	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
B2B01_RS03335	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
B2B01_RS03340	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
B2B01_RS03345	COG0586	Pfam SNARE associated Golgi protein
B2B01_RS03355	COG0028	Belongs to the TPP enzyme family
B2B01_RS03360	COG0579	oxidoreductase
B2B01_RS03375	COG0860	N-Acetylmuramoyl-L-alanine amidase
B2B01_RS03380	COG0802	atpase or kinase
B2B01_RS03385	COG0114	fumarate hydratase activity
B2B01_RS03395	COG3181	Tripartite tricarboxylate transporter family receptor
B2B01_RS03415	COG1116	anion transmembrane transporter activity
B2B01_RS03420	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B2B01_RS03445	COG0625	glutathione transferase activity
B2B01_RS03450	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B2B01_RS03460	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
B2B01_RS03470	COG2885	chlorophyll binding
B2B01_RS03485	COG0840	transmembrane signaling receptor activity
B2B01_RS03495	COG5265	(ABC) transporter
B2B01_RS03505	COG0833	amino acid
B2B01_RS03535	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
B2B01_RS03545	COG1408	metallophosphoesterase
B2B01_RS03560	COG2814	Major facilitator Superfamily
B2B01_RS03565	COG2610	gluconate transmembrane transporter activity
B2B01_RS03570	COG0625	glutathione transferase activity
B2B01_RS03575	COG2070	2-Nitropropane dioxygenase
B2B01_RS03585	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
B2B01_RS03610	COG0783	Belongs to the Dps family
B2B01_RS03630	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
B2B01_RS03635	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
B2B01_RS03640	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
B2B01_RS03645	COG1845	cytochrome c oxidase, subunit III
B2B01_RS03650	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
B2B01_RS03670	COG1666	GTP binding
B2B01_RS03690	COG1262	PFAM Formylglycine-generating sulfatase enzyme
B2B01_RS03700	COG1136	(ABC) transporter
B2B01_RS03750	COG1028	Short-chain dehydrogenase reductase Sdr
B2B01_RS03755	COG5006	permease, DMT superfamily
B2B01_RS03770	COG2264	protein methyltransferase activity
B2B01_RS03780	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
B2B01_RS03785	COG3383	formate dehydrogenase (NAD+) activity
B2B01_RS03805	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
B2B01_RS03815	COG0303	'Molybdopterin
B2B01_RS03820	COG0521	Mo-molybdopterin cofactor biosynthetic process
B2B01_RS03825	COG0314	molybdopterin synthase activity
B2B01_RS03830	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
B2B01_RS03835	COG0315	cyclic pyranopterin monophosphate synthase activity
B2B01_RS03845	COG0678	peroxiredoxin activity
B2B01_RS03855	COG0697	spore germination
B2B01_RS03860	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
B2B01_RS03910	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B2B01_RS03915	COG1702	phosphate starvation-inducible protein PhoH
B2B01_RS03920	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
B2B01_RS03925	COG4535	Mg2 and Co2 transporter CorC
B2B01_RS03930	COG0815	Transfers the fatty acyl group on membrane lipoproteins
B2B01_RS03935	COG0667	Aldo Keto reductase
B2B01_RS03955	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B2B01_RS03960	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B2B01_RS03965	COG1862	Preprotein translocase
B2B01_RS03970	COG0343	queuine tRNA-ribosyltransferase activity
B2B01_RS03975	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
B2B01_RS03980	COG2027	D-alanyl-D-alanine carboxypeptidase
B2B01_RS03985	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
B2B01_RS03990	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
B2B01_RS03990	COG1648	precorrin-2 dehydrogenase activity
B2B01_RS04020	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
B2B01_RS04035	COG0436	Aminotransferase
B2B01_RS04045	COG0280	phosphate acetyltransferase
B2B01_RS04045	COG0281	malic enzyme
B2B01_RS04060	COG1385	rRNA (uridine-N3-)-methyltransferase activity
B2B01_RS04065	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
B2B01_RS04070	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
B2B01_RS04075	COG0126	phosphoglycerate kinase activity
B2B01_RS04085	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
B2B01_RS04090	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
B2B01_RS04105	COG0625	glutathione transferase activity
B2B01_RS04135	COG0306	phosphate transporter
B2B01_RS04140	COG0521	Mo-molybdopterin cofactor biosynthetic process
B2B01_RS04150	COG0739	heme binding
B2B01_RS04160	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
B2B01_RS04170	COG0697	spore germination
B2B01_RS04185	COG0456	acetyltransferase
B2B01_RS04190	COG1301	dicarboxylic acid transport
B2B01_RS04200	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
B2B01_RS04205	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
B2B01_RS04210	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
B2B01_RS04215	COG0009	L-threonylcarbamoyladenylate synthase
B2B01_RS04220	COG1414	Transcriptional regulator
B2B01_RS04235	COG0765	amino acid transport
B2B01_RS04240	COG1126	abc transporter atp-binding protein
B2B01_RS04245	COG0028	Belongs to the TPP enzyme family
B2B01_RS04255	COG1960	acyl-CoA dehydrogenase activity
B2B01_RS04260	COG0028	Belongs to the TPP enzyme family
B2B01_RS04265	COG0583	DNA-binding transcription factor activity
B2B01_RS04270	COG4974	Belongs to the 'phage' integrase family
B2B01_RS04275	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
B2B01_RS04290	COG1686	Belongs to the peptidase S11 family
B2B01_RS04310	COG1074	ATP-dependent DNA helicase activity
B2B01_RS04320	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
B2B01_RS04325	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
B2B01_RS04330	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
B2B01_RS04340	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B2B01_RS04345	COG0505	Belongs to the CarA family
B2B01_RS04350	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
B2B01_RS04355	COG0406	alpha-ribazole phosphatase activity
B2B01_RS04365	COG3842	ATPase activity
B2B01_RS04385	COG2233	PERMEase
B2B01_RS04390	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B2B01_RS04400	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
B2B01_RS04405	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B2B01_RS04415	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B2B01_RS04435	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
B2B01_RS04435	COG3210	domain, Protein
B2B01_RS04435	COG3064	Membrane
B2B01_RS04440	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
B2B01_RS04440	COG3210	domain, Protein
B2B01_RS04440	COG3064	Membrane
B2B01_RS04460	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
B2B01_RS04485	COG2188	Transcriptional regulator
B2B01_RS04515	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
B2B01_RS04520	COG0066	3-isopropylmalate dehydratase activity
B2B01_RS04540	COG1053	succinate dehydrogenase
B2B01_RS04540	COG3976	FMN-binding domain protein
B2B01_RS04555	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
B2B01_RS04560	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B2B01_RS04580	COG1473	amidohydrolase
B2B01_RS04590	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B2B01_RS04605	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
B2B01_RS04630	COG1024	Enoyl-CoA hydratase
B2B01_RS04640	COG2267	carboxylic ester hydrolase activity
B2B01_RS04650	COG0318	PFAM AMP-dependent synthetase and ligase
B2B01_RS04705	COG1271	oxidase subunit
B2B01_RS04710	COG1294	oxidase, subunit
B2B01_RS04730	COG0154	amidase activity
B2B01_RS04735	COG4608	Belongs to the ABC transporter superfamily
B2B01_RS04740	COG0444	Belongs to the ABC transporter superfamily
B2B01_RS04745	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B2B01_RS04750	COG0601	transmembrane transport
B2B01_RS04755	COG4166	transmembrane transport
B2B01_RS04765	COG3706	GGDEF domain
B2B01_RS04785	COG0025	NhaP-type Na H and K H
B2B01_RS04815	COG1228	amidohydrolase
B2B01_RS04830	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
B2B01_RS04835	COG0500	methyltransferase
B2B01_RS04845	COG0840	transmembrane signaling receptor activity
B2B01_RS04870	COG2201	protein-glutamate methylesterase activity
B2B01_RS04875	COG3706	GGDEF domain
B2B01_RS04875	COG2203	Gaf domain
B2B01_RS04875	COG4251	negative regulation of phosphorylation
B2B01_RS04875	COG5001	Diguanylate cyclase
B2B01_RS04880	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
B2B01_RS04885	COG4166	transmembrane transport
B2B01_RS04905	COG0583	DNA-binding transcription factor activity
B2B01_RS04915	COG3181	Tripartite tricarboxylate transporter family receptor
B2B01_RS04930	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
B2B01_RS04955	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
B2B01_RS04960	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B2B01_RS04965	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B2B01_RS04970	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B2B01_RS04975	COG0649	NAD binding
B2B01_RS04980	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
B2B01_RS04990	COG1034	ATP synthesis coupled electron transport
B2B01_RS04995	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
B2B01_RS05000	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B2B01_RS05010	COG0713	ATP synthesis coupled electron transport
B2B01_RS05025	COG1007	ATP synthesis coupled electron transport
B2B01_RS05045	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
B2B01_RS05050	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
B2B01_RS05055	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
B2B01_RS05060	COG0560	Phosphoserine phosphatase
B2B01_RS05065	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B2B01_RS05070	COG0450	alkyl hydroperoxide reductase
B2B01_RS05075	COG2205	protein histidine kinase activity
B2B01_RS05080	COG0745	RESPONSE REGULATOR receiver
B2B01_RS05085	COG1214	PFAM Peptidase M22, glycoprotease
B2B01_RS05090	COG1573	uracil-dna glycosylase
B2B01_RS05095	COG0477	Major facilitator Superfamily
B2B01_RS05100	COG1196	nuclear chromosome segregation
B2B01_RS05110	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
B2B01_RS05115	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B2B01_RS05125	COG2917	probably involved in intracellular septation
B2B01_RS05130	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B2B01_RS05135	COG1122	ATPase activity
B2B01_RS05140	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
B2B01_RS05145	COG1268	BioY protein
B2B01_RS05205	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
B2B01_RS05210	COG2878	Part of a membrane complex involved in electron transport
B2B01_RS05230	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
B2B01_RS05235	COG0251	oxidation-reduction process
B2B01_RS05245	COG3228	Belongs to the MtfA family
B2B01_RS05250	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B2B01_RS05265	COG0159	tryptophan synthase activity
B2B01_RS05270	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
B2B01_RS05275	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
B2B01_RS05290	COG1530	ribonuclease E activity
B2B01_RS05295	COG0564	pseudouridine synthase activity
B2B01_RS05300	COG0546	phosphoglycolate phosphatase activity
B2B01_RS05305	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
B2B01_RS05310	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
B2B01_RS05315	COG3023	N-Acetylmuramoyl-L-alanine amidase
B2B01_RS05325	COG0424	maF-like protein
B2B01_RS05330	COG1399	metal-binding, possibly nucleic acid-binding protein
B2B01_RS05335	COG0333	Belongs to the bacterial ribosomal protein bL32 family
B2B01_RS05345	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B2B01_RS05355	COG1028	Short-chain dehydrogenase reductase Sdr
B2B01_RS05360	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B2B01_RS05365	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B2B01_RS05385	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B2B01_RS05390	COG0481	GTPase activity
B2B01_RS05395	COG0681	Belongs to the peptidase S26 family
B2B01_RS05400	COG0571	ribonuclease III activity
B2B01_RS05405	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
B2B01_RS05410	COG1381	Involved in DNA repair and RecF pathway recombination
B2B01_RS05430	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
B2B01_RS05440	COG0583	DNA-binding transcription factor activity
B2B01_RS05455	COG0583	DNA-binding transcription factor activity
B2B01_RS05465	COG0791	NLP P60 protein
B2B01_RS05470	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B2B01_RS05475	COG3193	protein, possibly involved in utilization of glycolate and propanediol
B2B01_RS05485	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B2B01_RS05490	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
B2B01_RS05525	COG1446	asparaginase
B2B01_RS05530	COG4172	Belongs to the ABC transporter superfamily
B2B01_RS05535	COG0747	negative chemotaxis
B2B01_RS05540	COG0601	transmembrane transport
B2B01_RS05545	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B2B01_RS05565	COG0504	CTP synthase activity
B2B01_RS05570	COG0148	phosphopyruvate hydratase activity
B2B01_RS05585	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
B2B01_RS05595	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B2B01_RS05610	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B2B01_RS05640	COG0039	L-malate dehydrogenase activity
B2B01_RS05645	COG2188	Transcriptional regulator
B2B01_RS05650	COG2009	succinate dehydrogenase
B2B01_RS05655	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
B2B01_RS05660	COG1053	succinate dehydrogenase
B2B01_RS05665	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
B2B01_RS05670	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
B2B01_RS05675	COG0372	Belongs to the citrate synthase family
B2B01_RS05680	COG3706	GGDEF domain
B2B01_RS05685	COG0583	DNA-binding transcription factor activity
B2B01_RS05690	COG3842	ATPase activity
B2B01_RS05700	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B2B01_RS05705	COG1840	ABC-type Fe3 transport system, periplasmic component
B2B01_RS05710	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B2B01_RS05710	COG2022	thiamine diphosphate biosynthetic process
B2B01_RS05720	COG3128	pkhd-type hydroxylase
B2B01_RS05725	COG4774	siderophore transport
B2B01_RS05740	COG0280	phosphate acetyltransferase
B2B01_RS05740	COG0281	malic enzyme
B2B01_RS05750	COG1297	OPT oligopeptide transporter protein
B2B01_RS05755	COG0567	Dehydrogenase, E1 component
B2B01_RS05760	COG0508	dehydrogenase complex catalyzes the overall conversion of
B2B01_RS05765	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B2B01_RS05770	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
B2B01_RS05775	COG1595	DNA-templated transcription, initiation
B2B01_RS05780	COG3712	iron ion homeostasis
B2B01_RS05785	COG4774	siderophore transport
B2B01_RS05810	COG1199	ATP-dependent helicase activity
B2B01_RS05815	COG2183	response to ionizing radiation
B2B01_RS05830	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
B2B01_RS05830	COG3210	domain, Protein
B2B01_RS05830	COG3064	Membrane
B2B01_RS05840	COG0564	pseudouridine synthase activity
B2B01_RS05850	COG3243	poly(R)-hydroxyalkanoic acid synthase
B2B01_RS05855	COG1028	Short-chain dehydrogenase reductase Sdr
B2B01_RS05860	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
B2B01_RS05875	COG0672	)-iron permease
B2B01_RS05900	COG3237	CsbD-like
B2B01_RS05905	COG0189	ligase activity
B2B01_RS05905	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
B2B01_RS05910	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
B2B01_RS05910	COG0189	ligase activity
B2B01_RS05915	COG1132	(ABC) transporter
B2B01_RS05925	COG0297	glycogen (starch) synthase activity
B2B01_RS05930	COG2833	Protein of unknown function (DUF455)
B2B01_RS05935	COG2951	lytic endotransglycosylase activity
B2B01_RS05950	COG0586	Pfam SNARE associated Golgi protein
B2B01_RS05965	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
B2B01_RS05970	COG0463	Glycosyl transferase, family 2
B2B01_RS05980	COG3958	Transketolase
B2B01_RS05985	COG3959	Transketolase, thiamine diphosphate binding domain
B2B01_RS06010	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
B2B01_RS06030	COG3971	2-oxopent-4-enoate hydratase activity
B2B01_RS06045	COG0179	Fumarylacetoacetate (FAA) hydrolase
B2B01_RS06050	COG1012	belongs to the aldehyde dehydrogenase family
B2B01_RS06070	COG0154	amidase activity
B2B01_RS06125	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
B2B01_RS06140	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
B2B01_RS06150	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B2B01_RS06160	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
B2B01_RS06165	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
B2B01_RS06185	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
B2B01_RS06190	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
B2B01_RS06195	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B2B01_RS06210	COG2951	lytic endotransglycosylase activity
B2B01_RS06230	COG2985	domain, Protein
B2B01_RS06235	COG1960	acyl-CoA dehydrogenase activity
B2B01_RS06240	COG0450	alkyl hydroperoxide reductase
B2B01_RS06265	COG0335	large ribosomal subunit rRNA binding
B2B01_RS06275	COG3622	Belongs to the hyi family
B2B01_RS06280	COG1162	GTPase activity
B2B01_RS06285	COG0501	Belongs to the peptidase M48B family
B2B01_RS06290	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
B2B01_RS06295	COG3327	negative regulation of DNA-templated transcription, initiation
B2B01_RS06300	COG3396	Phenylacetate-CoA oxygenase
B2B01_RS06305	COG3460	Phenylacetate-CoA oxygenase
B2B01_RS06310	COG3396	Phenylacetate-CoA oxygenase
B2B01_RS06315	COG2151	metal-sulfur cluster biosynthetic enzyme
B2B01_RS06320	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
B2B01_RS06330	COG1024	Enoyl-CoA hydratase
B2B01_RS06335	COG2050	protein possibly involved in aromatic compounds catabolism
B2B01_RS06355	COG0635	Involved in the biosynthesis of porphyrin-containing compound
B2B01_RS06360	COG2197	response regulator
B2B01_RS06365	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
B2B01_RS06370	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
B2B01_RS06385	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
B2B01_RS06390	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B2B01_RS06395	COG1914	H( )-stimulated, divalent metal cation uptake system
B2B01_RS06400	COG2423	ornithine cyclodeaminase activity
B2B01_RS06410	COG0756	dUTP diphosphatase activity
B2B01_RS06435	COG1522	sequence-specific DNA binding
B2B01_RS06445	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
B2B01_RS06450	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
B2B01_RS06455	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
B2B01_RS06460	COG0196	riboflavin kinase activity
B2B01_RS06465	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
B2B01_RS06470	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B2B01_RS06470	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
B2B01_RS06485	COG0210	DNA helicase
B2B01_RS06490	COG0488	(ABC) transporter
B2B01_RS06495	COG2890	protein-(glutamine-N5) methyltransferase activity
B2B01_RS06500	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B2B01_RS06505	COG2171	N-acyltransferase activity
B2B01_RS06520	COG0582	viral genome integration into host DNA
B2B01_RS06545	COG3723	Recombinational DNA repair protein, rece pathway
B2B01_RS06550	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
B2B01_RS06655	COG4626	Terminase
B2B01_RS06655	COG1802	Transcriptional regulator
B2B01_RS06785	COG2944	sequence-specific DNA binding
B2B01_RS06815	COG1278	Cold shock
B2B01_RS06825	COG1278	Cold shock
B2B01_RS06835	COG0544	peptidyl-prolyl cis-trans isomerase activity
B2B01_RS06840	COG0740	serine-type endopeptidase activity
B2B01_RS06845	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
B2B01_RS06850	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
B2B01_RS06860	COG3135	benzoate transporter
B2B01_RS06865	COG2814	Major facilitator Superfamily
B2B01_RS06870	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
B2B01_RS06880	COG0556	nucleotide-excision repair
B2B01_RS06885	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B2B01_RS06895	COG1104	cysteine desulfurase activity
B2B01_RS06900	COG0822	iron-sulfur transferase activity
B2B01_RS06910	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
B2B01_RS06915	COG0443	Heat shock 70 kDa protein
B2B01_RS06920	COG0633	Ferredoxin
B2B01_RS06925	COG2975	iron-sulfur cluster assembly
B2B01_RS06930	COG1803	Methylglyoxal synthase
B2B01_RS06940	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
B2B01_RS06945	COG1028	Short-chain dehydrogenase reductase Sdr
B2B01_RS06955	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
B2B01_RS06970	COG1136	(ABC) transporter
B2B01_RS06975	COG0084	hydrolase, TatD family'
B2B01_RS06990	COG1529	Aldehyde oxidase and xanthine dehydrogenase
B2B01_RS06990	COG2010	Cytochrome c
B2B01_RS06995	COG1335	isochorismatase
B2B01_RS07000	COG2309	aminopeptidase activity
B2B01_RS07005	COG0596	Alpha beta hydrolase
B2B01_RS07010	COG3473	Maleate cis-trans isomerase
B2B01_RS07020	COG2080	2 iron, 2 sulfur cluster binding
B2B01_RS07025	COG2010	Cytochrome c
B2B01_RS07025	COG1529	Aldehyde oxidase and xanthine dehydrogenase
B2B01_RS07030	COG0477	Major facilitator Superfamily
B2B01_RS07035	COG1846	Transcriptional regulator
B2B01_RS07045	COG2271	Major facilitator Superfamily
B2B01_RS07055	COG0820	rRNA (adenine-C2-)-methyltransferase activity
B2B01_RS07065	COG2200	EAL domain
B2B01_RS07075	COG0613	PHP domain protein
B2B01_RS07085	COG0047	phosphoribosylformylglycinamidine synthase activity
B2B01_RS07085	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B2B01_RS07095	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
B2B01_RS07095	COG3064	Membrane
B2B01_RS07095	COG3210	domain, Protein
B2B01_RS07095	COG3064	Membrane
B2B01_RS07095	COG3210	domain, Protein
B2B01_RS07095	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
B2B01_RS07130	COG0747	negative chemotaxis
B2B01_RS07135	COG4608	Belongs to the ABC transporter superfamily
B2B01_RS07145	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B2B01_RS07150	COG0601	transmembrane transport
B2B01_RS07155	COG2072	flavoprotein involved in K transport
B2B01_RS07175	COG0518	GMP synthase (glutamine-hydrolyzing) activity
B2B01_RS07175	COG0519	Catalyzes the synthesis of GMP from XMP
B2B01_RS07215	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
B2B01_RS07225	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
B2B01_RS07230	COG2146	nitrite reductase [NAD(P)H] activity
B2B01_RS07235	COG0446	pyridine nucleotide-disulphide oxidoreductase
B2B01_RS07245	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
B2B01_RS07250	COG1846	Transcriptional regulator
B2B01_RS07255	COG0477	Major facilitator Superfamily
B2B01_RS07260	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
B2B01_RS07260	COG3608	succinylglutamate desuccinylase aspartoacylase
B2B01_RS07280	COG3046	protein related to deoxyribodipyrimidine photolyase
B2B01_RS07285	COG0415	Belongs to the DNA photolyase family
B2B01_RS07290	COG0322	excinuclease ABC activity
B2B01_RS07320	COG0302	gtp cyclohydrolase
B2B01_RS07325	COG0789	Transcriptional regulator
B2B01_RS07330	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
B2B01_RS07335	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
B2B01_RS07345	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
B2B01_RS07355	COG0596	Alpha beta hydrolase
B2B01_RS07365	COG2814	Major facilitator Superfamily
B2B01_RS07370	COG0640	Transcriptional regulator
B2B01_RS07375	COG0833	amino acid
B2B01_RS07380	COG2814	Major facilitator Superfamily
B2B01_RS07425	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
B2B01_RS07450	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
B2B01_RS07455	COG1136	(ABC) transporter
B2B01_RS07455	COG0577	efflux transmembrane transporter activity
B2B01_RS07460	COG0390	transport system, permease component
B2B01_RS07505	COG0165	Argininosuccinate lyase
B2B01_RS07510	COG0668	transmembrane transport
B2B01_RS07545	COG0583	DNA-binding transcription factor activity
B2B01_RS07555	COG0747	negative chemotaxis
B2B01_RS07560	COG0601	transmembrane transport
B2B01_RS07570	COG4172	Belongs to the ABC transporter superfamily
B2B01_RS07575	COG1280	lysine exporter protein (LysE YggA)
B2B01_RS07585	COG3161	chorismate lyase activity
B2B01_RS07590	COG1187	pseudouridine synthase activity
B2B01_RS07630	COG1999	signal sequence binding
B2B01_RS07635	COG0339	signal peptide processing
B2B01_RS07640	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
B2B01_RS07645	COG4566	intracellular signal transduction
B2B01_RS07655	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
B2B01_RS07660	COG0508	dehydrogenase complex catalyzes the overall conversion of
B2B01_RS07665	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B2B01_RS07670	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
B2B01_RS07670	COG4797	methyltransferase
B2B01_RS07710	COG0745	RESPONSE REGULATOR receiver
B2B01_RS07715	COG0643	Histidine kinase
B2B01_RS07715	COG2198	Histidine kinase
B2B01_RS07725	COG0840	transmembrane signaling receptor activity
B2B01_RS07730	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
B2B01_RS07735	COG2201	protein-glutamate methylesterase activity
B2B01_RS07740	COG0745	RESPONSE REGULATOR receiver
B2B01_RS07745	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
B2B01_RS07770	COG2747	anti-sigma28 factor FlgM
B2B01_RS07780	COG1815	bacterial-type flagellum-dependent cell motility
B2B01_RS07795	COG1749	Flagellar hook protein flgE
B2B01_RS07800	COG4787	bacterial-type flagellum-dependent cell motility
B2B01_RS07815	COG1706	bacterial-type flagellum-dependent cell motility
B2B01_RS07835	COG0840	transmembrane signaling receptor activity
B2B01_RS07840	COG0840	transmembrane signaling receptor activity
B2B01_RS07850	COG0840	transmembrane signaling receptor activity
B2B01_RS07855	COG0840	transmembrane signaling receptor activity
B2B01_RS07890	COG1580	Controls the rotational direction of flagella during chemotaxis
B2B01_RS07910	COG1317	bacterial-type flagellum organization
B2B01_RS07915	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
B2B01_RS07920	COG1766	The M ring may be actively involved in energy transduction
B2B01_RS07925	COG1677	Flagellar hook-basal body complex protein FliE
B2B01_RS07935	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
B2B01_RS07955	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
B2B01_RS07965	COG0285	dihydrofolate synthase activity
B2B01_RS07975	COG1286	toxin biosynthetic process
B2B01_RS07985	COG5383	Protein conserved in bacteria
B2B01_RS07995	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
B2B01_RS08000	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
B2B01_RS08005	COG0024	Methionine aminopeptidase
B2B01_RS08010	COG0052	Belongs to the universal ribosomal protein uS2 family
B2B01_RS08015	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
B2B01_RS08020	COG0528	UMP kinase activity
B2B01_RS08025	COG0233	cytoplasmic translational termination
B2B01_RS08030	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
B2B01_RS08035	COG0575	Belongs to the CDS family
B2B01_RS08040	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
B2B01_RS08045	COG0750	zinc metalloprotease
B2B01_RS08050	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B2B01_RS08055	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
B2B01_RS08060	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B2B01_RS08065	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
B2B01_RS08075	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B2B01_RS08080	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
B2B01_RS08085	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B2B01_RS08095	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
B2B01_RS08115	COG3706	GGDEF domain
B2B01_RS08120	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
B2B01_RS08125	COG2867	negative regulation of translational initiation
B2B01_RS08130	COG2914	Belongs to the UPF0125 (RnfH) family
B2B01_RS08135	COG1960	acyl-CoA dehydrogenase activity
B2B01_RS08140	COG1250	3-hydroxyacyl-CoA dehydrogenase
B2B01_RS08140	COG1024	Enoyl-CoA hydratase
B2B01_RS08160	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
B2B01_RS08165	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
B2B01_RS08175	COG0084	hydrolase, TatD family'
B2B01_RS08215	COG3121	Chaperone
B2B01_RS08225	COG3539	Fimbrial protein
B2B01_RS08235	COG0833	amino acid
B2B01_RS08270	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B2B01_RS08295	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B2B01_RS08300	COG0456	acetyltransferase
B2B01_RS08310	COG2900	Belongs to the SlyX family
B2B01_RS08315	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B2B01_RS08330	COG0519	Catalyzes the synthesis of GMP from XMP
B2B01_RS08330	COG0518	GMP synthase (glutamine-hydrolyzing) activity
B2B01_RS08335	COG0583	DNA-binding transcription factor activity
B2B01_RS08340	COG0477	Major facilitator Superfamily
B2B01_RS08365	COG3258	Cytochrome c
B2B01_RS08395	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B2B01_RS08400	COG1129	ABC transporter
B2B01_RS08400	COG0842	Transport permease protein
B2B01_RS08405	COG0842	Transport permease protein
B2B01_RS08415	COG2259	Doxx family
B2B01_RS08435	COG0154	amidase activity
B2B01_RS08440	COG0477	Major facilitator Superfamily
B2B01_RS08450	COG0218	Necessary for normal cell division and for the maintenance of normal septation
B2B01_RS08470	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B2B01_RS08485	COG0386	Belongs to the glutathione peroxidase family
B2B01_RS08495	COG0095	Lipoate-protein ligase
B2B01_RS08505	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
B2B01_RS08510	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B2B01_RS08515	COG0477	Major facilitator Superfamily
B2B01_RS08520	COG2391	methyltransferase activity
B2B01_RS08525	COG2897	thiosulfate sulfurtransferase activity
B2B01_RS08540	COG0431	NADPH-dependent FMN reductase
B2B01_RS08545	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B2B01_RS08550	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B2B01_RS08555	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B2B01_RS08565	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B2B01_RS08580	COG1695	Transcriptional regulator
B2B01_RS08590	COG2819	hydrolase of the alpha beta superfamily
B2B01_RS08640	COG1126	abc transporter atp-binding protein
B2B01_RS08645	COG0765	amino acid transport
B2B01_RS08660	COG2200	EAL domain
B2B01_RS08675	COG1253	flavin adenine dinucleotide binding
B2B01_RS08680	COG4251	negative regulation of phosphorylation
B2B01_RS08680	COG5001	Diguanylate cyclase
B2B01_RS08680	COG2203	Gaf domain
B2B01_RS08680	COG3706	GGDEF domain
B2B01_RS08685	COG2197	response regulator
B2B01_RS08690	COG2205	protein histidine kinase activity
B2B01_RS08690	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B2B01_RS08700	COG2186	Transcriptional regulator
B2B01_RS08705	COG0028	Belongs to the TPP enzyme family
B2B01_RS08715	COG0688	phosphatidylethanolamine metabolic process
B2B01_RS08725	COG1464	Belongs to the NlpA lipoprotein family
B2B01_RS08740	COG2363	Small membrane protein
B2B01_RS08745	COG0697	spore germination
B2B01_RS08750	COG0625	glutathione transferase activity
B2B01_RS08755	COG1794	racemase activity, acting on amino acids and derivatives
B2B01_RS08775	COG0559	Belongs to the binding-protein-dependent transport system permease family
B2B01_RS08790	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
B2B01_RS08800	COG1653	transport
B2B01_RS08805	COG1175	transmembrane transport
B2B01_RS08810	COG0395	ABC-type sugar transport system, permease component
B2B01_RS08815	COG3842	ATPase activity
B2B01_RS08830	COG0783	Belongs to the Dps family
B2B01_RS08865	COG0625	glutathione transferase activity
B2B01_RS08885	COG2186	Transcriptional regulator
B2B01_RS08900	COG0583	DNA-binding transcription factor activity
B2B01_RS08905	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
B2B01_RS08920	COG1840	ABC-type Fe3 transport system, periplasmic component
B2B01_RS08930	COG3842	ATPase activity
B2B01_RS08935	COG1741	Belongs to the pirin family
B2B01_RS08940	COG1741	Belongs to the pirin family
B2B01_RS08945	COG0583	DNA-binding transcription factor activity
B2B01_RS08955	COG3852	Histidine kinase
B2B01_RS08960	COG0174	glutamine synthetase
B2B01_RS08965	COG0635	Involved in the biosynthesis of porphyrin-containing compound
B2B01_RS08970	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
B2B01_RS08975	COG3300	MHYT domain
B2B01_RS08975	COG5001	Diguanylate cyclase
B2B01_RS08980	COG0840	transmembrane signaling receptor activity
B2B01_RS08990	COG1561	YicC-like family, N-terminal region
B2B01_RS08995	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B2B01_RS09010	COG0653	protein targeting
B2B01_RS09045	COG4585	Histidine kinase
B2B01_RS09060	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
B2B01_RS09065	COG0791	NLP P60 protein
B2B01_RS09070	COG1028	Short-chain dehydrogenase reductase Sdr
B2B01_RS09075	COG0194	GDP metabolic process
B2B01_RS09080	COG1758	RNA polymerase activity
B2B01_RS09085	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B2B01_RS09090	COG1126	abc transporter atp-binding protein
B2B01_RS09095	COG0765	amino acid transport
B2B01_RS09100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B2B01_RS09105	COG2831	hemolysin activation secretion protein
B2B01_RS09115	COG3188	usher protein
B2B01_RS09120	COG3121	Chaperone
B2B01_RS09125	COG3539	Fimbrial protein
B2B01_RS09130	COG3064	Membrane
B2B01_RS09130	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
B2B01_RS09130	COG3210	domain, Protein
B2B01_RS09130	COG3064	Membrane
B2B01_RS09130	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
B2B01_RS09130	COG3210	domain, Protein
B2B01_RS09135	COG4181	ATPase activity
B2B01_RS09145	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B2B01_RS09150	COG0584	glycerophosphoryl diester phosphodiesterase
B2B01_RS09155	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
B2B01_RS09165	COG0678	peroxiredoxin activity
B2B01_RS09165	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
B2B01_RS09180	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B2B01_RS09200	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
B2B01_RS09205	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
B2B01_RS09210	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
B2B01_RS09215	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
B2B01_RS09220	COG2252	PERMEase
B2B01_RS09225	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B2B01_RS09230	COG3118	belongs to the thioredoxin family
B2B01_RS09260	COG0488	(ABC) transporter
B2B01_RS09265	COG1619	proteins homologs of microcin C7 resistance protein MccF
B2B01_RS09285	COG1320	monovalent cation:proton antiporter activity
B2B01_RS09290	COG2212	antiporter activity
B2B01_RS09295	COG1863	multisubunit Na H antiporter MnhE subunit
B2B01_RS09300	COG0651	ATP synthesis coupled electron transport
B2B01_RS09305	COG1006	Multisubunit Na H antiporter MnhC subunit
B2B01_RS09310	COG2111	Na H antiporter
B2B01_RS09310	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
B2B01_RS09325	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B2B01_RS09345	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
B2B01_RS09355	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
B2B01_RS09360	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
B2B01_RS09395	COG0602	queuosine metabolic process
B2B01_RS09400	COG0720	synthase
B2B01_RS09410	COG1289	transmembrane transporter activity
B2B01_RS09420	COG1566	PFAM secretion protein HlyD family protein
B2B01_RS09430	COG0400	carboxylic ester hydrolase activity
B2B01_RS09445	COG0587	DNA-directed DNA polymerase activity
B2B01_RS09450	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B2B01_RS09465	COG1610	YqeY-like protein
B2B01_RS09545	COG3193	protein, possibly involved in utilization of glycolate and propanediol
B2B01_RS09570	COG1522	sequence-specific DNA binding
B2B01_RS09585	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
B2B01_RS09610	COG0776	regulation of translation
B2B01_RS09615	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B2B01_RS09615	COG0072	phenylalanine-tRNA ligase activity
B2B01_RS09620	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
B2B01_RS09625	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
B2B01_RS09630	COG0291	Belongs to the bacterial ribosomal protein bL35 family
B2B01_RS09640	COG2960	long-chain fatty acid transporting porin activity
B2B01_RS09660	COG0004	ammonium transporteR
B2B01_RS09690	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
B2B01_RS09705	COG1090	epimerase
B2B01_RS09710	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
B2B01_RS09710	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
B2B01_RS09710	COG0506	proline dehydrogenase activity
B2B01_RS09720	COG3008	intermembrane lipid transfer
B2B01_RS09725	COG2995	paraquat-inducible protein a
B2B01_RS09730	COG0542	response to heat
B2B01_RS09735	COG4953	penicillin-binding protein 1C
B2B01_RS09745	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
B2B01_RS09750	COG1278	Cold shock
B2B01_RS09760	COG0183	Belongs to the thiolase family
B2B01_RS09765	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
B2B01_RS09770	COG1570	exodeoxyribonuclease VII activity
B2B01_RS09775	COG0811	peptide transport
B2B01_RS09785	COG1663	tetraacyldisaccharide 4'-kinase activity
B2B01_RS09790	COG2835	tetraacyldisaccharide 4'-kinase activity
B2B01_RS09795	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
B2B01_RS09800	COG0563	adenylate kinase activity
B2B01_RS09810	COG0728	peptidoglycan biosynthetic process
B2B01_RS09820	COG0268	Binds directly to 16S ribosomal RNA
B2B01_RS09825	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B2B01_RS09835	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B2B01_RS09840	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
B2B01_RS09855	COG3158	transport of potassium into the cell
B2B01_RS09860	COG0642	Histidine kinase
B2B01_RS09865	COG0745	RESPONSE REGULATOR receiver
B2B01_RS09890	COG0776	regulation of translation
B2B01_RS09895	COG0626	cystathionine gamma-synthase activity
B2B01_RS09900	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B2B01_RS09905	COG0557	exoribonuclease II activity
B2B01_RS09935	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
B2B01_RS09940	COG2391	methyltransferase activity
B2B01_RS09950	COG0583	DNA-binding transcription factor activity
B2B01_RS09955	COG0069	glutamate synthase activity
B2B01_RS09965	COG0582	viral genome integration into host DNA
B2B01_RS10210	COG3706	GGDEF domain
B2B01_RS10215	COG3706	GGDEF domain
B2B01_RS10225	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B2B01_RS10250	COG3909	cytochrome
B2B01_RS10260	COG0625	glutathione transferase activity
B2B01_RS10265	COG0730	response to heat
B2B01_RS10270	COG0482	sulfurtransferase activity
B2B01_RS10290	COG0247	lactate metabolic process
B2B01_RS10295	COG0277	FAD linked oxidase domain protein
B2B01_RS10300	COG0277	FAD linked oxidase domain protein
B2B01_RS10305	COG0277	FAD linked oxidase domain protein
B2B01_RS10310	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
B2B01_RS10315	COG0312	modulator of DNA gyrase
B2B01_RS10330	COG0308	aminopeptidase N
B2B01_RS10335	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
B2B01_RS10375	COG0436	Aminotransferase
B2B01_RS10380	COG3737	Protein of unknown function (DUF498/DUF598)
B2B01_RS10385	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
B2B01_RS10390	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
B2B01_RS10395	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
B2B01_RS10405	COG0305	Participates in initiation and elongation during chromosome replication
B2B01_RS10415	COG0359	binds to the 23S rRNA
B2B01_RS10420	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
B2B01_RS10425	COG2965	DNA replication, synthesis of RNA primer
B2B01_RS10430	COG0360	Binds together with S18 to 16S ribosomal RNA
B2B01_RS10435	COG1469	GTP cyclohydrolase I activity
B2B01_RS10440	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
B2B01_RS10445	COG0142	geranyltranstransferase activity
B2B01_RS10450	COG1722	exodeoxyribonuclease VII activity
B2B01_RS10475	COG0501	Belongs to the peptidase M48B family
B2B01_RS10490	COG0697	spore germination
B2B01_RS10500	COG1846	Transcriptional regulator
B2B01_RS10505	COG1538	Outer membrane efflux protein
B2B01_RS10510	COG1566	PFAM secretion protein HlyD family protein
B2B01_RS10515	COG2814	Major facilitator Superfamily
B2B01_RS10520	COG0473	3-isopropylmalate dehydrogenase activity
B2B01_RS10530	COG0747	negative chemotaxis
B2B01_RS10540	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B2B01_RS10550	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
B2B01_RS10575	COG1012	belongs to the aldehyde dehydrogenase family
B2B01_RS10585	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B2B01_RS10595	COG0217	transcriptional regulatory protein
B2B01_RS10600	COG0151	Belongs to the GarS family
B2B01_RS10610	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
B2B01_RS10615	COG0799	negative regulation of ribosome biogenesis
B2B01_RS10620	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
B2B01_RS10625	COG0424	maF-like protein
B2B01_RS10645	COG2169	Transcriptional regulator
B2B01_RS10645	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
B2B01_RS10650	COG1301	dicarboxylic acid transport
B2B01_RS10655	COG4191	Histidine kinase
B2B01_RS10660	COG2204	response regulator
B2B01_RS10675	COG1418	mRNA catabolic process
B2B01_RS10680	COG0500	methyltransferase
B2B01_RS10685	COG0477	Major facilitator Superfamily
B2B01_RS10695	COG0583	DNA-binding transcription factor activity
B2B01_RS10730	COG1530	ribonuclease E activity
B2B01_RS10735	COG1132	(ABC) transporter
B2B01_RS10750	COG0297	glycogen (starch) synthase activity
B2B01_RS10755	COG0726	polysaccharide deacetylase
B2B01_RS10760	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B2B01_RS10765	COG0463	Glycosyl transferase, family 2
B2B01_RS10770	COG0726	polysaccharide deacetylase
B2B01_RS10775	COG0438	transferase activity, transferring glycosyl groups
B2B01_RS10790	COG1643	Atp-dependent helicase
B2B01_RS10795	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
B2B01_RS10795	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
B2B01_RS10800	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
B2B01_RS10810	COG0704	Plays a role in the regulation of phosphate uptake
B2B01_RS10815	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
B2B01_RS10820	COG1322	Protein conserved in bacteria
B2B01_RS10830	COG2094	Belongs to the DNA glycosylase MPG family
B2B01_RS10840	COG1177	transmembrane transport
B2B01_RS10845	COG1176	ABC-type spermidine putrescine transport system, permease component I
B2B01_RS10850	COG3842	ATPase activity
B2B01_RS10860	COG3642	lipopolysaccharide core region biosynthetic process
B2B01_RS10865	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
B2B01_RS10870	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
B2B01_RS10905	COG0135	phosphoribosylanthranilate isomerase activity
B2B01_RS10910	COG0101	tRNA pseudouridine synthase activity
B2B01_RS10920	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
B2B01_RS10925	COG0473	3-isopropylmalate dehydrogenase activity
B2B01_RS10930	COG0066	3-isopropylmalate dehydratase activity
B2B01_RS10940	COG0501	Belongs to the peptidase M48B family
B2B01_RS10945	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
B2B01_RS10955	COG2205	protein histidine kinase activity
B2B01_RS10965	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
B2B01_RS10970	COG1295	ribonuclease BN
B2B01_RS10980	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B2B01_RS10985	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
B2B01_RS11050	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
B2B01_RS11065	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
B2B01_RS11085	COG0181	hydroxymethylbilane synthase activity
B2B01_RS11090	COG0861	Integral membrane protein TerC family
B2B01_RS11095	COG0861	Integral membrane protein TerC family
B2B01_RS11100	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
B2B01_RS11105	COG0045	succinate-CoA ligase (ADP-forming) activity
B2B01_RS11115	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
B2B01_RS11125	COG2137	regulation of response to DNA damage stimulus
B2B01_RS11130	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
B2B01_RS11140	COG0642	Histidine kinase
B2B01_RS11145	COG0477	Major facilitator Superfamily
B2B01_RS11150	COG2974	May be involved in recombination
B2B01_RS11155	COG0540	Belongs to the ATCase OTCase family
B2B01_RS11185	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B2B01_RS11200	COG2770	Histidine kinase
B2B01_RS11200	COG3437	response regulator, receiver
B2B01_RS11215	COG1278	Cold shock
B2B01_RS11435	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
B2B01_RS11440	COG3723	Recombinational DNA repair protein, rece pathway
B2B01_RS11480	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
B2B01_RS11500	COG0828	Belongs to the bacterial ribosomal protein bS21 family
B2B01_RS11510	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
B2B01_RS11515	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
B2B01_RS11520	COG0330	HflC and HflK could
B2B01_RS11525	COG0330	HflC and HflK could
B2B01_RS11530	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
B2B01_RS11535	COG1923	regulation of RNA biosynthetic process
B2B01_RS11540	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B2B01_RS11545	COG1160	GTP binding
B2B01_RS11550	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B2B01_RS11555	COG2976	Protein conserved in bacteria
B2B01_RS11560	COG0124	histidyl-tRNA synthetase
B2B01_RS11575	COG0820	rRNA (adenine-C2-)-methyltransferase activity
B2B01_RS11580	COG0105	UTP biosynthetic process
B2B01_RS11585	COG0525	valine-tRNA ligase activity
B2B01_RS11590	COG0336	Belongs to the RNA methyltransferase TrmD family
B2B01_RS11595	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
B2B01_RS11600	COG0228	four-way junction DNA binding
B2B01_RS11610	COG0425	Belongs to the sulfur carrier protein TusA family
B2B01_RS11615	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
B2B01_RS11665	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B2B01_RS11670	COG0543	2 iron, 2 sulfur cluster binding
B2B01_RS11670	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
B2B01_RS11675	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
B2B01_RS11680	COG2076	Multidrug Resistance protein
B2B01_RS11685	COG0633	Ferredoxin
B2B01_RS11685	COG3217	Mosc domain protein beta barrel domain protein
B2B01_RS11690	COG5285	phytanoyl-CoA dioxygenase
B2B01_RS11695	COG0662	Cupin 2, conserved barrel domain protein
B2B01_RS11705	COG0456	acetyltransferase
B2B01_RS11735	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
B2B01_RS11745	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
B2B01_RS11750	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
B2B01_RS11755	COG1760	l-serine dehydratase
B2B01_RS11760	COG1283	sodium-dependent phosphate transmembrane transporter activity
B2B01_RS11765	COG0412	Dienelactone hydrolase
B2B01_RS11775	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B2B01_RS11775	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B2B01_RS11780	COG1611	Belongs to the LOG family
B2B01_RS11795	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
B2B01_RS11800	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
B2B01_RS11805	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
B2B01_RS11810	COG0195	Participates in both transcription termination and antitermination
B2B01_RS11810	COG2251	uridine kinase activity
B2B01_RS11815	COG0779	Required for maturation of 30S ribosomal subunits
B2B01_RS11825	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
B2B01_RS11835	COG0523	cobalamin synthesis protein
B2B01_RS11850	COG0625	glutathione transferase activity
B2B01_RS11855	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
B2B01_RS11865	COG2003	Belongs to the UPF0758 family
B2B01_RS11870	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
B2B01_RS11875	COG3483	tryptophan 2,3-dioxygenase activity
B2B01_RS11915	COG1028	Short-chain dehydrogenase reductase Sdr
B2B01_RS11920	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
B2B01_RS11925	COG1562	ergosterol biosynthetic process
B2B01_RS11930	COG1562	ergosterol biosynthetic process
B2B01_RS11935	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
B2B01_RS11940	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
B2B01_RS11950	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
B2B01_RS11955	COG0583	DNA-binding transcription factor activity
B2B01_RS11960	COG0542	response to heat
B2B01_RS11965	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B2B01_RS11980	COG0494	nUDIX hydrolase
B2B01_RS11990	COG0583	DNA-binding transcription factor activity
B2B01_RS11995	COG3530	Putative quorum-sensing-regulated virulence factor
B2B01_RS12035	COG2814	Major facilitator Superfamily
B2B01_RS12045	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
B2B01_RS12055	COG0628	permease
B2B01_RS12060	COG0842	Transport permease protein
B2B01_RS12065	COG1131	(ABC) transporter
B2B01_RS12070	COG1764	response to oxidative stress
B2B01_RS12075	COG1846	Transcriptional regulator
B2B01_RS12080	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B2B01_RS12085	COG0156	8-amino-7-oxononanoate synthase activity
B2B01_RS12095	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
B2B01_RS12095	COG4106	trans-aconitate 2-methyltransferase activity
B2B01_RS12110	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
B2B01_RS12110	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
B2B01_RS12120	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
B2B01_RS12125	COG0322	excinuclease ABC activity
B2B01_RS12130	COG1472	Belongs to the glycosyl hydrolase 3 family
B2B01_RS12135	COG0736	holo-[acyl-carrier-protein] synthase activity
B2B01_RS12140	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
B2B01_RS12150	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B2B01_RS12155	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B2B01_RS12160	COG0745	RESPONSE REGULATOR receiver
B2B01_RS12175	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
B2B01_RS12180	COG4149	molybdate abc transporter
B2B01_RS12185	COG0725	ABC transporter, periplasmic molybdate-binding protein
B2B01_RS12190	COG1122	ATPase activity
B2B01_RS12195	COG4120	Belongs to the binding-protein-dependent transport system permease family
B2B01_RS12200	COG2984	ABC transporter substrate binding protein
B2B01_RS12210	COG2032	superoxide dismutase activity
B2B01_RS12225	COG0183	Belongs to the thiolase family
B2B01_RS12235	COG3448	diguanylate cyclase activity
B2B01_RS12235	COG4175	Glycine betaine
B2B01_RS12240	COG4176	ABC-type proline glycine betaine transport system permease component
B2B01_RS12250	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
B2B01_RS12255	COG2814	Major facilitator Superfamily
B2B01_RS12260	COG0227	Belongs to the bacterial ribosomal protein bL28 family
B2B01_RS12265	COG0267	Belongs to the bacterial ribosomal protein bL33 family
B2B01_RS12290	COG2814	Major facilitator Superfamily
B2B01_RS12295	COG0495	leucyl-tRNA aminoacylation
B2B01_RS12310	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
B2B01_RS12325	COG0154	amidase activity
B2B01_RS12370	COG0427	acetyl-CoA hydrolase
B2B01_RS12375	COG0583	DNA-binding transcription factor activity
B2B01_RS12380	COG1511	domain protein
B2B01_RS12380	COG3264	Mechanosensitive ion channel
B2B01_RS12390	COG0697	spore germination
B2B01_RS12415	COG0243	molybdopterin cofactor binding
B2B01_RS12440	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
B2B01_RS12445	COG3384	dioxygenase
B2B01_RS12460	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
B2B01_RS12465	COG4221	oxidoreductase activity
B2B01_RS12475	COG2814	Major facilitator Superfamily
B2B01_RS12480	COG0583	DNA-binding transcription factor activity
B2B01_RS12545	COG5001	Diguanylate cyclase
B2B01_RS12545	COG3300	MHYT domain
B2B01_RS12565	COG4172	Belongs to the ABC transporter superfamily
B2B01_RS12570	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B2B01_RS12575	COG0601	transmembrane transport
B2B01_RS12580	COG0747	negative chemotaxis
B2B01_RS12590	COG0598	Magnesium transport protein CorA
B2B01_RS12600	COG1801	Protein of unknown function DUF72
B2B01_RS12610	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
B2B01_RS12615	COG1012	belongs to the aldehyde dehydrogenase family
B2B01_RS12625	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
B2B01_RS12630	COG1045	serine acetyltransferase
B2B01_RS12635	COG1250	3-hydroxyacyl-CoA dehydrogenase
B2B01_RS12635	COG1024	Enoyl-CoA hydratase
B2B01_RS12640	COG0183	Belongs to the thiolase family
B2B01_RS12655	COG1902	pentaerythritol trinitrate reductase activity
B2B01_RS12685	COG4695	Portal protein
B2B01_RS12855	COG0582	viral genome integration into host DNA
B2B01_RS12865	COG0527	aspartate kinase activity
B2B01_RS12875	COG0825	malonyl-CoA metabolic process
B2B01_RS12885	COG0215	cysteine-tRNA ligase activity
B2B01_RS12895	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
B2B01_RS12900	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B2B01_RS12905	COG1968	undecaprenyl-diphosphatase activity
B2B01_RS12910	COG1253	flavin adenine dinucleotide binding
B2B01_RS12945	COG0668	transmembrane transport
B2B01_RS12995	COG1802	Transcriptional regulator
B2B01_RS13015	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
B2B01_RS13020	COG2850	peptidyl-arginine hydroxylation
B2B01_RS13030	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
B2B01_RS13035	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B2B01_RS13040	COG1994	Peptidase M50
B2B01_RS13045	COG0009	L-threonylcarbamoyladenylate synthase
B2B01_RS13050	COG2321	neutral zinc metallopeptidase
B2B01_RS13075	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B2B01_RS13090	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B2B01_RS13095	COG1404	Belongs to the peptidase S8 family
B2B01_RS13155	COG0531	amino acid
B2B01_RS13165	COG0076	glutamate decarboxylase activity
B2B01_RS13190	COG0457	Tetratricopeptide repeat
B2B01_RS13195	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
B2B01_RS13200	COG1215	transferase activity, transferring glycosyl groups
B2B01_RS13205	COG1215	transferase activity, transferring glycosyl groups
B2B01_RS13210	COG1215	transferase activity, transferring glycosyl groups
B2B01_RS13215	COG1192	Involved in chromosome partitioning
B2B01_RS13245	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
B2B01_RS13250	COG1596	polysaccharide export
B2B01_RS13275	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
B2B01_RS13315	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
B2B01_RS13325	COG4604	ABC transporter, ATP-binding protein
B2B01_RS13330	COG4605	iron ion homeostasis
B2B01_RS13335	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B2B01_RS13340	COG4607	ABC-type enterochelin transport system periplasmic component
B2B01_RS13345	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
B2B01_RS13350	COG0149	triose-phosphate isomerase activity
B2B01_RS13355	COG0604	alcohol dehydrogenase
B2B01_RS13355	COG3321	synthase
B2B01_RS13355	COG1028	Short-chain dehydrogenase reductase Sdr
B2B01_RS13380	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
B2B01_RS13390	COG0154	amidase activity
B2B01_RS13395	COG1185	polyribonucleotide nucleotidyltransferase activity
B2B01_RS13400	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
B2B01_RS13410	COG1183	phosphatidylcholine synthase activity
B2B01_RS13415	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
B2B01_RS13420	COG0440	acetolactate synthase activity
B2B01_RS13425	COG0028	Belongs to the TPP enzyme family
B2B01_RS13430	COG1289	transmembrane transporter activity
B2B01_RS13435	COG3022	response to hydroperoxide
B2B01_RS13440	COG1028	Short-chain dehydrogenase reductase Sdr
B2B01_RS13450	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B2B01_RS13455	COG0640	Transcriptional regulator
B2B01_RS13465	COG5001	Diguanylate cyclase
B2B01_RS13465	COG5002	protein histidine kinase activity
B2B01_RS13485	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
B2B01_RS13490	COG0531	amino acid
B2B01_RS13495	COG1982	Orn Lys Arg decarboxylase major
B2B01_RS13510	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
B2B01_RS13520	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
B2B01_RS13525	COG1674	ftsk spoiiie
B2B01_RS13530	COG0492	ferredoxin-NADP+ reductase activity
B2B01_RS13535	COG1193	negative regulation of DNA recombination
B2B01_RS13545	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B2B01_RS13560	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
B2B01_RS13565	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
B2B01_RS13570	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
B2B01_RS13575	COG2205	protein histidine kinase activity
B2B01_RS13580	COG0745	RESPONSE REGULATOR receiver
B2B01_RS13595	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B2B01_RS13610	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B2B01_RS13625	COG0612	Peptidase, M16
B2B01_RS13630	COG0484	heat shock protein binding
B2B01_RS13635	COG0443	Heat shock 70 kDa protein
B2B01_RS13645	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
B2B01_RS13655	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
B2B01_RS13660	COG1420	regulation of RNA biosynthetic process
B2B01_RS13665	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
B2B01_RS13670	COG0497	DNA recombination
B2B01_RS13675	COG0735	belongs to the Fur family
B2B01_RS13680	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B2B01_RS13705	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B2B01_RS13710	COG1683	Conserved Protein
B2B01_RS13725	COG2828	Protein conserved in bacteria
B2B01_RS13730	COG1280	lysine exporter protein (LysE YggA)
B2B01_RS13740	COG0582	viral genome integration into host DNA
B2B01_RS13750	COG1396	sequence-specific DNA binding
B2B01_RS13755	COG0583	DNA-binding transcription factor activity
B2B01_RS13760	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
B2B01_RS13765	COG0159	tryptophan synthase activity
B2B01_RS13770	COG0133	tryptophan synthase activity
B2B01_RS13775	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B2B01_RS13780	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
B2B01_RS13785	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
B2B01_RS13800	COG3135	benzoate transporter
B2B01_RS13810	COG1794	racemase activity, acting on amino acids and derivatives
B2B01_RS13815	COG0583	DNA-binding transcription factor activity
B2B01_RS13895	COG2003	Belongs to the UPF0758 family
B2B01_RS13955	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
B2B01_RS13960	COG1196	nuclear chromosome segregation
B2B01_RS13970	COG2189	Belongs to the N(4) N(6)-methyltransferase family
B2B01_RS14090	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B2B01_RS14095	COG0629	single-stranded DNA binding
B2B01_RS14175	COG1335	isochorismatase
B2B01_RS14180	COG2309	aminopeptidase activity
B2B01_RS14185	COG0596	Alpha beta hydrolase
B2B01_RS14190	COG3473	Maleate cis-trans isomerase
B2B01_RS14220	COG0583	DNA-binding transcription factor activity
B2B01_RS14230	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
B2B01_RS14235	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
B2B01_RS14240	COG0167	dihydroorotate dehydrogenase activity
B2B01_RS14255	COG1414	Transcriptional regulator
B2B01_RS14260	COG1058	Belongs to the CinA family
B2B01_RS14260	COG1546	Belongs to the CinA family
B2B01_RS14275	COG0513	Belongs to the DEAD box helicase family
B2B01_RS14300	COG0429	hydrolase of the alpha beta-hydrolase fold
B2B01_RS14305	COG4783	chaperone-mediated protein folding
B2B01_RS14315	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
B2B01_RS14335	COG0006	proline dipeptidase activity
B2B01_RS14340	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B2B01_RS14360	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
B2B01_RS14365	COG0632	four-way junction helicase activity
B2B01_RS14375	COG2255	four-way junction helicase activity
B2B01_RS14380	COG0514	ATP-dependent DNA helicase (RecQ)
B2B01_RS14390	COG0745	RESPONSE REGULATOR receiver
B2B01_RS14410	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B2B01_RS14415	COG0850	regulation of cytokinetic process
B2B01_RS14420	COG2894	cell division
B2B01_RS14425	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
B2B01_RS14440	COG0488	(ABC) transporter
B2B01_RS14445	COG2066	Belongs to the glutaminase family
B2B01_RS14450	COG0531	amino acid
B2B01_RS14460	COG0076	glutamate decarboxylase activity
B2B01_RS14475	COG4608	Belongs to the ABC transporter superfamily
B2B01_RS14480	COG0444	Belongs to the ABC transporter superfamily
B2B01_RS14485	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B2B01_RS14490	COG0601	transmembrane transport
B2B01_RS14495	COG0747	negative chemotaxis
B2B01_RS14500	COG1215	transferase activity, transferring glycosyl groups
B2B01_RS14510	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
B2B01_RS14515	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
B2B01_RS14525	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
B2B01_RS14530	COG1538	Outer membrane efflux protein
B2B01_RS14535	COG0577	efflux transmembrane transporter activity
B2B01_RS14535	COG1136	(ABC) transporter
B2B01_RS14550	COG0405	Gamma-glutamyltransferase
B2B01_RS14570	COG0579	oxidoreductase
B2B01_RS14575	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
B2B01_RS14580	COG0259	pyridoxamine-phosphate oxidase activity
B2B01_RS14650	COG1368	sulfuric ester hydrolase activity
B2B01_RS14705	COG2982	Protein involved in outer membrane biogenesis
B2B01_RS14710	COG2818	Glycosylase
B2B01_RS14715	COG0727	PFAM Uncharacterised protein family (UPF0153)
B2B01_RS14725	COG2877	3-deoxy-8-phosphooctulonate synthase activity
B2B01_RS14735	COG1464	Belongs to the NlpA lipoprotein family
B2B01_RS14740	COG2011	ABC-type metal ion transport system permease component
B2B01_RS14745	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
B2B01_RS14750	COG1501	Belongs to the glycosyl hydrolase 31 family
B2B01_RS14755	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B2B01_RS14755	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
B2B01_RS14765	COG0318	PFAM AMP-dependent synthetase and ligase
B2B01_RS14770	COG1473	amidohydrolase
B2B01_RS14775	COG0583	DNA-binding transcription factor activity
B2B01_RS14780	COG2855	membrane
B2B01_RS14790	COG2239	Acts as a magnesium transporter
B2B01_RS14805	COG1522	sequence-specific DNA binding
B2B01_RS14820	COG0653	protein targeting
B2B01_RS14825	COG0739	heme binding
B2B01_RS14840	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
B2B01_RS14855	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
B2B01_RS14860	COG1181	Belongs to the D-alanine--D-alanine ligase family
B2B01_RS14865	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
B2B01_RS14870	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B2B01_RS14880	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
B2B01_RS14885	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B2B01_RS14890	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
B2B01_RS14900	COG3116	cell division
B2B01_RS14905	COG0275	rRNA processing
B2B01_RS14910	COG2001	Belongs to the MraZ family
B2B01_RS14925	COG0418	dihydroorotase activity
B2B01_RS14930	COG1473	amidohydrolase
B2B01_RS14985	COG4654	Cytochrome c, class I
B2B01_RS14990	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
B2B01_RS15025	COG2084	Dehydrogenase
B2B01_RS15030	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
B2B01_RS15060	COG0442	prolyl-tRNA aminoacylation
B2B01_RS15065	COG0824	Thioesterase
B2B01_RS15070	COG0811	peptide transport
B2B01_RS15075	COG0848	biopolymer transport protein
B2B01_RS15085	COG0823	Involved in the tonB-independent uptake of proteins
B2B01_RS15105	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
B2B01_RS15120	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B2B01_RS15125	COG0697	spore germination
B2B01_RS15150	COG0463	Glycosyl transferase, family 2
B2B01_RS15170	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
B2B01_RS15175	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B2B01_RS15180	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B2B01_RS15185	COG0328	RNA-DNA hybrid ribonuclease activity
B2B01_RS15190	COG2226	methyltransferase
B2B01_RS15195	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B2B01_RS15200	COG1388	LysM domain
B2B01_RS15200	COG0741	lytic transglycosylase activity
B2B01_RS15280	COG2719	SpoVR family
B2B01_RS15285	COG2718	Belongs to the UPF0229 family
B2B01_RS15290	COG2766	serine protein kinase
B2B01_RS15300	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B2B01_RS15300	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B2B01_RS15315	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
B2B01_RS15320	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
B2B01_RS15330	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
B2B01_RS15340	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
B2B01_RS15345	COG0316	Belongs to the HesB IscA family
B2B01_RS15355	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
B2B01_RS15360	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
B2B01_RS15365	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
B2B01_RS15370	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
B2B01_RS15380	COG0312	modulator of DNA gyrase
B2B01_RS15385	COG3028	Belongs to the UPF0307 family
B2B01_RS15395	COG0045	succinate-CoA ligase (ADP-forming) activity
B2B01_RS15395	COG1042	CoA-binding domain protein
B2B01_RS15395	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B2B01_RS15395	COG0045	succinate-CoA ligase (ADP-forming) activity
B2B01_RS15395	COG1042	CoA-binding domain protein
B2B01_RS15395	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B2B01_RS15400	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B2B01_RS15445	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B2B01_RS15450	COG1696	Membrane protein involved in D-alanine export
B2B01_RS15480	COG2264	protein methyltransferase activity
B2B01_RS15485	COG0439	Biotin carboxylase
B2B01_RS15490	COG0511	ligase activity, forming carbon-carbon bonds
B2B01_RS15495	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
B2B01_RS15500	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B2B01_RS15505	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
B2B01_RS15510	COG3150	esterase
B2B01_RS15515	COG0557	exoribonuclease II activity
B2B01_RS15525	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
B2B01_RS15530	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B2B01_RS15540	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
B2B01_RS15560	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
B2B01_RS15565	COG1678	Uncharacterized ACR, COG1678
B2B01_RS15575	COG0351	phosphomethylpyrimidine kinase
B2B01_RS15580	COG0352	thiamine-phosphate diphosphorylase activity
B2B01_RS15585	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
B2B01_RS15610	COG1960	acyl-CoA dehydrogenase activity
B2B01_RS15615	COG1024	Enoyl-CoA hydratase
B2B01_RS15620	COG1028	Short-chain dehydrogenase reductase Sdr
B2B01_RS15630	COG3706	GGDEF domain
B2B01_RS15650	COG0410	ABC transporter
B2B01_RS15700	COG3539	Fimbrial protein
B2B01_RS15725	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
B2B01_RS15730	COG0237	dephospho-CoA kinase activity
B2B01_RS15735	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
B2B01_RS15750	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
B2B01_RS15755	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
B2B01_RS15765	COG0477	Major facilitator Superfamily
B2B01_RS15785	COG1126	abc transporter atp-binding protein
B2B01_RS15790	COG0765	amino acid transport
B2B01_RS15795	COG4597	amino acid ABC transporter
B2B01_RS15800	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B2B01_RS15805	COG2884	Cell division ATP-binding protein ftsE
B2B01_RS15810	COG2177	Part of the ABC transporter FtsEX involved in
B2B01_RS15815	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
B2B01_RS15835	COG2226	methyltransferase
B2B01_RS15845	COG4206	TonB-dependent receptor
B2B01_RS15850	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B2B01_RS15855	COG2022	thiamine diphosphate biosynthetic process
B2B01_RS15860	COG0351	phosphomethylpyrimidine kinase
B2B01_RS15870	COG1538	Outer membrane efflux protein
B2B01_RS15875	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
B2B01_RS15885	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
B2B01_RS15895	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
B2B01_RS15900	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
B2B01_RS15930	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B2B01_RS15955	COG2226	methyltransferase
B2B01_RS15960	COG0745	RESPONSE REGULATOR receiver
B2B01_RS15965	COG5002	protein histidine kinase activity
B2B01_RS15975	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B2B01_RS15980	COG0583	DNA-binding transcription factor activity
B2B01_RS15990	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
B2B01_RS15995	COG1984	allophanate hydrolase subunit 2
B2B01_RS16005	COG1802	Transcriptional regulator
B2B01_RS16015	COG1238	metal cluster binding
B2B01_RS16020	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
B2B01_RS16025	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
B2B01_RS16035	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B2B01_RS16040	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
B2B01_RS16045	COG4988	ABC transporter
B2B01_RS16050	COG4890	Cyd operon protein YbgT
B2B01_RS16055	COG1294	oxidase, subunit
B2B01_RS16070	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
B2B01_RS16080	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
B2B01_RS16095	COG1137	ATPase activity
B2B01_RS16100	COG0443	Heat shock 70 kDa protein
B2B01_RS16105	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
B2B01_RS16105	COG2169	Transcriptional regulator
B2B01_RS16110	COG3145	DNA-N1-methyladenine dioxygenase activity
B2B01_RS16115	COG0583	DNA-binding transcription factor activity
B2B01_RS16125	COG1473	amidohydrolase
B2B01_RS16130	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B2B01_RS16135	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B2B01_RS16155	COG1120	ATPase activity
B2B01_RS16160	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B2B01_RS16165	COG4558	Periplasmic binding protein
B2B01_RS16170	COG3720	iron ion transport
B2B01_RS16185	COG1595	DNA-templated transcription, initiation
B2B01_RS16205	COG1607	acyl-coa hydrolase
B2B01_RS16220	COG0437	4 iron, 4 sulfur cluster binding
B2B01_RS16225	COG2864	formate dehydrogenase
B2B01_RS16240	COG3276	selenocysteine insertion sequence binding
B2B01_RS16255	COG0583	DNA-binding transcription factor activity
B2B01_RS16265	COG0134	indole-3-glycerol-phosphate synthase activity
B2B01_RS16270	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
B2B01_RS16280	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
B2B01_RS16290	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
B2B01_RS16295	COG1660	Displays ATPase and GTPase activities
B2B01_RS16300	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
B2B01_RS16305	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
B2B01_RS16310	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
B2B01_RS16315	COG0792	nuclease activity
B2B01_RS16320	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
B2B01_RS16325	COG2823	Periplasmic or secreted lipoprotein
B2B01_RS16340	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
B2B01_RS16350	COG1309	transcriptional regulator
B2B01_RS16355	COG0471	metal ion transport
B2B01_RS16360	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
B2B01_RS16365	COG0772	Belongs to the SEDS family
B2B01_RS16370	COG0768	penicillin binding
B2B01_RS16380	COG1792	Involved in formation and maintenance of cell shape
B2B01_RS16385	COG1077	Cell shape determining protein MreB Mrl
B2B01_RS16390	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B2B01_RS16395	COG0154	amidase activity
B2B01_RS16400	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B2B01_RS16405	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
B2B01_RS16415	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
B2B01_RS16420	COG2860	membrane
B2B01_RS16430	COG2223	nitrite transmembrane transporter activity
B2B01_RS16440	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
B2B01_RS16475	COG1250	3-hydroxyacyl-CoA dehydrogenase
B2B01_RS16485	COG1960	acyl-CoA dehydrogenase activity
B2B01_RS16495	COG2070	2-Nitropropane dioxygenase
B2B01_RS16500	COG1024	Enoyl-CoA hydratase
B2B01_RS16505	COG1024	Enoyl-CoA hydratase
B2B01_RS16510	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
B2B01_RS16520	COG0747	negative chemotaxis
B2B01_RS16525	COG0601	transmembrane transport
B2B01_RS16530	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B2B01_RS16535	COG0444	Belongs to the ABC transporter superfamily
B2B01_RS16540	COG4608	Belongs to the ABC transporter superfamily
B2B01_RS16555	COG0210	DNA helicase
B2B01_RS16560	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
B2B01_RS16565	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
B2B01_RS16575	COG0355	proton-transporting ATP synthase activity, rotational mechanism
B2B01_RS16580	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
B2B01_RS16585	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
B2B01_RS16590	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
B2B01_RS16595	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B2B01_RS16600	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
B2B01_RS16610	COG0356	it plays a direct role in the translocation of protons across the membrane
B2B01_RS16620	COG1024	Enoyl-CoA hydratase
B2B01_RS16630	COG0492	ferredoxin-NADP+ reductase activity
B2B01_RS16640	COG0037	tRNA processing
B2B01_RS16650	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B2B01_RS16655	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
B2B01_RS16660	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B2B01_RS16665	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
B2B01_RS16670	COG2967	ApaG domain
B2B01_RS16675	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
B2B01_RS16680	COG0546	phosphoglycolate phosphatase activity
B2B01_RS16690	COG1671	Belongs to the UPF0178 family
B2B01_RS16705	COG0583	DNA-binding transcription factor activity
B2B01_RS16715	COG0129	dihydroxy-acid dehydratase activity
B2B01_RS16725	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
B2B01_RS16730	COG2326	polyphosphate kinase activity
B2B01_RS16735	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
B2B01_RS16770	COG3181	Tripartite tricarboxylate transporter family receptor
B2B01_RS16775	COG0583	DNA-binding transcription factor activity
B2B01_RS16780	COG1053	succinate dehydrogenase
B2B01_RS16780	COG3976	FMN-binding domain protein
B2B01_RS16800	COG3976	FMN-binding domain protein
B2B01_RS16800	COG0431	NADPH-dependent FMN reductase
B2B01_RS16800	COG1053	succinate dehydrogenase
B2B01_RS16830	COG1053	succinate dehydrogenase
B2B01_RS16865	COG1522	sequence-specific DNA binding
B2B01_RS16880	COG2814	Major facilitator Superfamily
B2B01_RS16885	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
B2B01_RS16900	COG1999	signal sequence binding
B2B01_RS16905	COG0109	protoheme IX farnesyltransferase activity
B2B01_RS16910	COG1612	heme a metabolic process
B2B01_RS16925	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
B2B01_RS16930	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
B2B01_RS16945	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
B2B01_RS16960	COG0067	glutamate synthase
B2B01_RS16960	COG0069	glutamate synthase activity
B2B01_RS16960	COG0070	glutamate synthase
B2B01_RS16990	COG1984	allophanate hydrolase subunit 2
B2B01_RS17005	COG0511	ligase activity, forming carbon-carbon bonds
B2B01_RS17010	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
B2B01_RS17020	COG3047	cAMP biosynthetic process
B2B01_RS17025	COG1127	ABC transporter
B2B01_RS17030	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
B2B01_RS17035	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
B2B01_RS17040	COG2853	Lipoprotein
B2B01_RS17050	COG1131	(ABC) transporter
B2B01_RS17055	COG0842	Transport permease protein
B2B01_RS17065	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
B2B01_RS17070	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
B2B01_RS17075	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
B2B01_RS17080	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B2B01_RS17085	COG0131	Imidazoleglycerol-phosphate dehydratase
B2B01_RS17095	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
B2B01_RS17100	COG0107	imidazoleglycerol-phosphate synthase activity
B2B01_RS17105	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
B2B01_RS17110	COG0140	phosphoribosyl-ATP diphosphatase activity
B2B01_RS17115	COG0537	adenosine 5'-monophosphoramidase activity
B2B01_RS17120	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B2B01_RS17125	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B2B01_RS17135	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B2B01_RS17140	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
B2B01_RS17145	COG1970	mechanosensitive ion channel activity
B2B01_RS17150	COG0723	plastoquinol--plastocyanin reductase activity
B2B01_RS17155	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
B2B01_RS17160	COG2857	Cytochrome c1
B2B01_RS17165	COG0625	glutathione transferase activity
B2B01_RS17170	COG2969	positive regulation of protein catabolic process
B2B01_RS17195	COG1160	GTP binding
B2B01_RS17210	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B2B01_RS17220	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
B2B01_RS17230	COG0513	Belongs to the DEAD box helicase family
B2B01_RS17235	COG1280	lysine exporter protein (LysE YggA)
B2B01_RS17240	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
B2B01_RS17260	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
B2B01_RS17270	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B2B01_RS17275	COG0154	amidase activity
B2B01_RS17280	COG1609	Transcriptional regulator
B2B01_RS17300	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
B2B01_RS17305	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
B2B01_RS17320	COG0018	arginyl-trna synthetase
B2B01_RS17330	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
B2B01_RS17335	COG2200	EAL domain
B2B01_RS17345	COG1280	lysine exporter protein (LysE YggA)
B2B01_RS17360	COG1960	acyl-CoA dehydrogenase activity
B2B01_RS17365	COG0183	Belongs to the thiolase family
B2B01_RS17370	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B2B01_RS17385	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B2B01_RS17395	COG1629	transport
B2B01_RS17400	COG2922	Belongs to the Smg family
B2B01_RS17405	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B2B01_RS17420	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
B2B01_RS17425	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
B2B01_RS17430	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B2B01_RS17435	COG1028	Short-chain dehydrogenase reductase Sdr
B2B01_RS17440	COG1012	belongs to the aldehyde dehydrogenase family
B2B01_RS17450	COG0028	Belongs to the TPP enzyme family
B2B01_RS17455	COG1522	sequence-specific DNA binding
B2B01_RS17460	COG3781	membrane
B2B01_RS17485	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
B2B01_RS17490	COG1744	ABC transporter substrate-binding protein PnrA-like
B2B01_RS17510	COG0402	S-adenosylhomocysteine deaminase activity
B2B01_RS17525	COG1254	Belongs to the acylphosphatase family
B2B01_RS17530	COG2010	Cytochrome c
B2B01_RS17530	COG1529	Aldehyde oxidase and xanthine dehydrogenase
B2B01_RS17540	COG1529	Aldehyde oxidase and xanthine dehydrogenase
B2B01_RS17555	COG1690	Belongs to the RtcB family
B2B01_RS17560	COG4650	regulator
B2B01_RS17575	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
B2B01_RS17585	COG0230	Belongs to the bacterial ribosomal protein bL34 family
B2B01_RS17590	COG0594	ribonuclease P activity
B2B01_RS17595	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
B2B01_RS17600	COG0706	membrane insertase activity
B2B01_RS17605	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
B2B01_RS17610	COG1473	amidohydrolase
B2B01_RS17615	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
B2B01_RS17620	COG1505	serine-type exopeptidase activity
B2B01_RS17630	COG0281	malic enzyme
B2B01_RS17630	COG0280	phosphate acetyltransferase
B2B01_RS17645	COG0436	Aminotransferase
B2B01_RS17650	COG1278	Cold shock