locus-tag	class	description
G6545_RS00030	COG2186	Transcriptional regulator
G6545_RS00050	COG1175	transmembrane transport
G6545_RS00055	COG0395	ABC-type sugar transport system, permease component
G6545_RS00060	COG3842	ATPase activity
G6545_RS00065	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
G6545_RS00070	COG1653	transport
G6545_RS00090	COG2818	Glycosylase
G6545_RS00095	COG2982	Protein involved in outer membrane biogenesis
G6545_RS00100	COG1309	transcriptional regulator
G6545_RS00105	COG1028	Short-chain dehydrogenase reductase Sdr
G6545_RS00215	COG3384	dioxygenase
G6545_RS00235	COG0583	DNA-binding transcription factor activity
G6545_RS00250	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
G6545_RS00255	COG2353	YceI-like domain
G6545_RS00260	COG4774	siderophore transport
G6545_RS00265	COG3712	iron ion homeostasis
G6545_RS00280	COG0019	diaminopimelate decarboxylase activity
G6545_RS00295	COG0747	negative chemotaxis
G6545_RS00300	COG0601	transmembrane transport
G6545_RS00305	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G6545_RS00315	COG0154	amidase activity
G6545_RS00320	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
G6545_RS00340	COG2154	pterin-4-alpha-carbinolamine dehydratase
G6545_RS00350	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
G6545_RS00365	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
G6545_RS00370	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
G6545_RS00375	COG1929	Belongs to the glycerate kinase type-1 family
G6545_RS00380	COG0469	pyruvate kinase activity
G6545_RS00385	COG0700	Nucleoside recognition
G6545_RS00390	COG1960	acyl-CoA dehydrogenase activity
G6545_RS00395	COG0242	peptide deformylase activity
G6545_RS00410	COG0204	Acyl-transferase
G6545_RS00415	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
G6545_RS00420	COG0751	glycine-tRNA ligase activity
G6545_RS00425	COG0752	glycyl-tRNA synthetase alpha subunit
G6545_RS00440	COG0066	3-isopropylmalate dehydratase activity
G6545_RS00445	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
G6545_RS00450	COG2188	Transcriptional regulator
G6545_RS00460	COG1024	Enoyl-CoA hydratase
G6545_RS00470	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
G6545_RS00480	COG2301	Belongs to the HpcH HpaI aldolase family
G6545_RS00485	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G6545_RS00490	COG3181	Tripartite tricarboxylate transporter family receptor
G6545_RS00495	COG1028	Short-chain dehydrogenase reductase Sdr
G6545_RS00505	COG1028	Short-chain dehydrogenase reductase Sdr
G6545_RS00510	COG1234	tRNA 3'-trailer cleavage
G6545_RS00515	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
G6545_RS00525	COG2188	Transcriptional regulator
G6545_RS00530	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
G6545_RS00555	COG0617	tRNA 3'-terminal CCA addition
G6545_RS00570	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
G6545_RS00575	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
G6545_RS00585	COG0586	Pfam SNARE associated Golgi protein
G6545_RS00590	COG0860	N-Acetylmuramoyl-L-alanine amidase
G6545_RS00595	COG0802	atpase or kinase
G6545_RS00610	COG3181	Tripartite tricarboxylate transporter family receptor
G6545_RS00620	COG0405	Gamma-glutamyltransferase
G6545_RS00625	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G6545_RS00630	COG3181	Tripartite tricarboxylate transporter family receptor
G6545_RS00635	COG1960	acyl-CoA dehydrogenase activity
G6545_RS00640	COG0583	DNA-binding transcription factor activity
G6545_RS00655	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
G6545_RS00660	COG0259	pyridoxamine-phosphate oxidase activity
G6545_RS00670	COG2814	Major facilitator Superfamily
G6545_RS00675	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
G6545_RS00680	COG2188	Transcriptional regulator
G6545_RS00685	COG0318	PFAM AMP-dependent synthetase and ligase
G6545_RS00700	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
G6545_RS00710	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
G6545_RS00720	COG1215	transferase activity, transferring glycosyl groups
G6545_RS00730	COG0601	transmembrane transport
G6545_RS00735	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G6545_RS00740	COG0444	Belongs to the ABC transporter superfamily
G6545_RS00745	COG4608	Belongs to the ABC transporter superfamily
G6545_RS00770	COG0488	(ABC) transporter
G6545_RS00785	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
G6545_RS00790	COG2894	cell division
G6545_RS00795	COG0850	regulation of cytokinetic process
G6545_RS00800	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
G6545_RS00805	COG1271	oxidase subunit
G6545_RS00820	COG0745	RESPONSE REGULATOR receiver
G6545_RS00830	COG0514	ATP-dependent DNA helicase (RecQ)
G6545_RS00835	COG2255	four-way junction helicase activity
G6545_RS00850	COG0632	four-way junction helicase activity
G6545_RS00855	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
G6545_RS00875	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
G6545_RS00885	COG0006	proline dipeptidase activity
G6545_RS00900	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
G6545_RS00915	COG4783	chaperone-mediated protein folding
G6545_RS00920	COG0429	hydrolase of the alpha beta-hydrolase fold
G6545_RS00950	COG0513	Belongs to the DEAD box helicase family
G6545_RS00965	COG1058	Belongs to the CinA family
G6545_RS00965	COG1546	Belongs to the CinA family
G6545_RS00970	COG1414	Transcriptional regulator
G6545_RS00985	COG0167	dihydroorotate dehydrogenase activity
G6545_RS00990	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
G6545_RS00995	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
G6545_RS01005	COG0583	DNA-binding transcription factor activity
G6545_RS01035	COG1280	lysine exporter protein (LysE YggA)
G6545_RS01050	COG0405	Gamma-glutamyltransferase
G6545_RS01060	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G6545_RS01070	COG0730	response to heat
G6545_RS01075	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
G6545_RS01100	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
G6545_RS01125	COG1024	Enoyl-CoA hydratase
G6545_RS01135	COG2030	dehydratase
G6545_RS01140	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G6545_RS01150	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
G6545_RS01160	COG0583	DNA-binding transcription factor activity
G6545_RS01170	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G6545_RS01175	COG4311	Sarcosine oxidase, delta subunit
G6545_RS01180	COG0404	The glycine cleavage system catalyzes the degradation of glycine
G6545_RS01180	COG0446	pyridine nucleotide-disulphide oxidoreductase
G6545_RS01195	COG3181	Tripartite tricarboxylate transporter family receptor
G6545_RS01215	COG0812	UDP-N-acetylmuramate dehydrogenase activity
G6545_RS01225	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
G6545_RS01230	COG0735	belongs to the Fur family
G6545_RS01235	COG0497	DNA recombination
G6545_RS01245	COG1420	regulation of RNA biosynthetic process
G6545_RS01250	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
G6545_RS01260	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
G6545_RS01270	COG0443	Heat shock 70 kDa protein
G6545_RS01275	COG0484	heat shock protein binding
G6545_RS01280	COG0612	Peptidase, M16
G6545_RS01300	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
G6545_RS01335	COG0745	RESPONSE REGULATOR receiver
G6545_RS01340	COG2205	protein histidine kinase activity
G6545_RS01345	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
G6545_RS01350	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
G6545_RS01355	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
G6545_RS01370	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
G6545_RS01380	COG1193	negative regulation of DNA recombination
G6545_RS01385	COG0492	ferredoxin-NADP+ reductase activity
G6545_RS01390	COG1674	ftsk spoiiie
G6545_RS01395	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
G6545_RS01400	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
G6545_RS01430	COG3706	GGDEF domain
G6545_RS01480	COG3486	L-lysine 6-monooxygenase (NADPH) activity
G6545_RS01495	COG1028	Short-chain dehydrogenase reductase Sdr
G6545_RS01500	COG3022	response to hydroperoxide
G6545_RS01510	COG1289	transmembrane transporter activity
G6545_RS01515	COG0028	Belongs to the TPP enzyme family
G6545_RS01520	COG0440	acetolactate synthase activity
G6545_RS01530	COG1183	phosphatidylcholine synthase activity
G6545_RS01545	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
G6545_RS01550	COG1185	polyribonucleotide nucleotidyltransferase activity
G6545_RS01560	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
G6545_RS01580	COG0149	triose-phosphate isomerase activity
G6545_RS01585	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
G6545_RS01595	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
G6545_RS01605	COG3799	methylaspartate ammonia-lyase activity
G6545_RS01620	COG0165	Argininosuccinate lyase
G6545_RS01625	COG3181	Tripartite tricarboxylate transporter family receptor
G6545_RS01635	COG0583	DNA-binding transcription factor activity
G6545_RS01640	COG0626	cystathionine gamma-synthase activity
G6545_RS01645	COG3608	succinylglutamate desuccinylase aspartoacylase
G6545_RS01665	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G6545_RS01685	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
G6545_RS01700	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G6545_RS01705	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G6545_RS01710	COG1733	regulation of RNA biosynthetic process
G6545_RS01715	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
G6545_RS01720	COG0583	DNA-binding transcription factor activity
G6545_RS01725	COG1597	lipid kinase activity
G6545_RS01735	COG0671	phosphoesterase, PA-phosphatase related
G6545_RS01755	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
G6545_RS01760	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G6545_RS01765	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G6545_RS01770	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G6545_RS01780	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
G6545_RS01790	COG1034	ATP synthesis coupled electron transport
G6545_RS01795	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
G6545_RS01800	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G6545_RS01810	COG0713	ATP synthesis coupled electron transport
G6545_RS01825	COG1007	ATP synthesis coupled electron transport
G6545_RS01835	COG4774	siderophore transport
G6545_RS01840	COG4774	siderophore transport
G6545_RS01855	COG0028	Belongs to the TPP enzyme family
G6545_RS01860	COG3181	Tripartite tricarboxylate transporter family receptor
G6545_RS01865	COG0583	DNA-binding transcription factor activity
G6545_RS01870	COG0560	Phosphoserine phosphatase
G6545_RS01875	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
G6545_RS01880	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
G6545_RS01885	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
G6545_RS01890	COG2223	nitrite transmembrane transporter activity
G6545_RS01900	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
G6545_RS01905	COG0450	alkyl hydroperoxide reductase
G6545_RS01910	COG2205	protein histidine kinase activity
G6545_RS01915	COG0745	RESPONSE REGULATOR receiver
G6545_RS01920	COG1214	PFAM Peptidase M22, glycoprotease
G6545_RS01925	COG1573	uracil-dna glycosylase
G6545_RS01930	COG0477	Major facilitator Superfamily
G6545_RS01935	COG1196	nuclear chromosome segregation
G6545_RS01945	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
G6545_RS01950	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
G6545_RS01955	COG0271	Belongs to the BolA IbaG family
G6545_RS01965	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
G6545_RS01970	COG1122	ATPase activity
G6545_RS01975	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
G6545_RS01980	COG1268	BioY protein
G6545_RS02005	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
G6545_RS02040	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
G6545_RS02045	COG2878	Part of a membrane complex involved in electron transport
G6545_RS02060	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
G6545_RS02065	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
G6545_RS02070	COG0251	oxidation-reduction process
G6545_RS02080	COG3228	Belongs to the MtfA family
G6545_RS02085	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
G6545_RS02100	COG0159	tryptophan synthase activity
G6545_RS02105	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
G6545_RS02110	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
G6545_RS02120	COG1530	ribonuclease E activity
G6545_RS02130	COG0546	phosphoglycolate phosphatase activity
G6545_RS02135	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
G6545_RS02145	COG3023	N-Acetylmuramoyl-L-alanine amidase
G6545_RS02160	COG1399	metal-binding, possibly nucleic acid-binding protein
G6545_RS02165	COG0333	Belongs to the bacterial ribosomal protein bL32 family
G6545_RS02175	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
G6545_RS02190	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
G6545_RS02195	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
G6545_RS02220	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
G6545_RS02235	COG0571	ribonuclease III activity
G6545_RS02240	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
G6545_RS02245	COG1381	Involved in DNA repair and RecF pathway recombination
G6545_RS02255	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
G6545_RS02270	COG0670	Belongs to the BI1 family
G6545_RS02295	COG0583	DNA-binding transcription factor activity
G6545_RS02310	COG0583	DNA-binding transcription factor activity
G6545_RS02320	COG0791	NLP P60 protein
G6545_RS02325	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
G6545_RS02330	COG3193	protein, possibly involved in utilization of glycolate and propanediol
G6545_RS02340	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
G6545_RS02345	COG0697	spore germination
G6545_RS02350	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
G6545_RS02365	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
G6545_RS02395	COG1446	asparaginase
G6545_RS02400	COG4172	Belongs to the ABC transporter superfamily
G6545_RS02405	COG0747	negative chemotaxis
G6545_RS02415	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G6545_RS02435	COG0504	CTP synthase activity
G6545_RS02440	COG2877	3-deoxy-8-phosphooctulonate synthase activity
G6545_RS02450	COG0148	phosphopyruvate hydratase activity
G6545_RS02455	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
G6545_RS02485	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
G6545_RS02495	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
G6545_RS02530	COG2828	Protein conserved in bacteria
G6545_RS02550	COG0039	L-malate dehydrogenase activity
G6545_RS02555	COG2188	Transcriptional regulator
G6545_RS02560	COG2009	succinate dehydrogenase
G6545_RS02565	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
G6545_RS02570	COG1053	succinate dehydrogenase
G6545_RS02575	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
G6545_RS02580	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
G6545_RS02585	COG0372	Belongs to the citrate synthase family
G6545_RS02600	COG3539	Fimbrial protein
G6545_RS02605	COG0281	malic enzyme
G6545_RS02605	COG0280	phosphate acetyltransferase
G6545_RS02615	COG1522	sequence-specific DNA binding
G6545_RS02620	COG1297	OPT oligopeptide transporter protein
G6545_RS02625	COG0567	Dehydrogenase, E1 component
G6545_RS02630	COG0508	dehydrogenase complex catalyzes the overall conversion of
G6545_RS02635	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
G6545_RS02640	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
G6545_RS02645	COG1028	Short-chain dehydrogenase reductase Sdr
G6545_RS02650	COG0583	DNA-binding transcription factor activity
G6545_RS02655	COG3181	Tripartite tricarboxylate transporter family receptor
G6545_RS02665	COG2175	clavaminate synthase activity
G6545_RS02670	COG1595	DNA-templated transcription, initiation
G6545_RS02675	COG3712	iron ion homeostasis
G6545_RS02680	COG4774	siderophore transport
G6545_RS02705	COG2183	response to ionizing radiation
G6545_RS02710	COG1199	ATP-dependent helicase activity
G6545_RS02720	COG0564	pseudouridine synthase activity
G6545_RS02730	COG3243	poly(R)-hydroxyalkanoic acid synthase
G6545_RS02735	COG1028	Short-chain dehydrogenase reductase Sdr
G6545_RS02740	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
G6545_RS02755	COG0672	)-iron permease
G6545_RS02770	COG2823	Periplasmic or secreted lipoprotein
G6545_RS02780	COG3237	CsbD-like
G6545_RS02785	COG1181	Belongs to the D-alanine--D-alanine ligase family
G6545_RS02785	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
G6545_RS02790	COG0189	ligase activity
G6545_RS02790	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
G6545_RS02795	COG1132	(ABC) transporter
G6545_RS02810	COG2833	Protein of unknown function (DUF455)
G6545_RS02815	COG2951	lytic endotransglycosylase activity
G6545_RS02825	COG0589	response to stress
G6545_RS02830	COG3706	GGDEF domain
G6545_RS02835	COG2814	Major facilitator Superfamily
G6545_RS02840	COG0778	Nitroreductase
G6545_RS02860	COG0436	Aminotransferase
G6545_RS02865	COG0028	Belongs to the TPP enzyme family
G6545_RS02865	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
G6545_RS02875	COG0583	DNA-binding transcription factor activity
G6545_RS02890	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G6545_RS02900	COG2079	MmgE PrpD family protein
G6545_RS02905	COG1012	belongs to the aldehyde dehydrogenase family
G6545_RS02910	COG1053	succinate dehydrogenase
G6545_RS02935	COG0179	Fumarylacetoacetate (FAA) hydrolase
G6545_RS02950	COG0583	DNA-binding transcription factor activity
G6545_RS02990	COG0583	DNA-binding transcription factor activity
G6545_RS03000	COG2814	Major facilitator Superfamily
G6545_RS03010	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
G6545_RS03035	COG0287	Prephenate dehydrogenase
G6545_RS03040	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
G6545_RS03045	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
G6545_RS03065	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
G6545_RS03070	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
G6545_RS03080	COG1596	polysaccharide export
G6545_RS03080	COG1555	photosystem II stabilization
G6545_RS03090	COG2951	lytic endotransglycosylase activity
G6545_RS03095	COG0123	including yeast histone deacetylase and acetoin utilization protein
G6545_RS03110	COG1960	acyl-CoA dehydrogenase activity
G6545_RS03115	COG0450	alkyl hydroperoxide reductase
G6545_RS03130	COG4208	sulfate ABC transporter
G6545_RS03140	COG0175	sulfate reduction
G6545_RS03170	COG0335	large ribosomal subunit rRNA binding
G6545_RS03180	COG0667	Aldo Keto reductase
G6545_RS03185	COG1162	GTPase activity
G6545_RS03190	COG0501	Belongs to the peptidase M48B family
G6545_RS03195	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
G6545_RS03205	COG3327	negative regulation of DNA-templated transcription, initiation
G6545_RS03210	COG3396	Phenylacetate-CoA oxygenase
G6545_RS03215	COG3460	Phenylacetate-CoA oxygenase
G6545_RS03220	COG3396	Phenylacetate-CoA oxygenase
G6545_RS03225	COG2151	metal-sulfur cluster biosynthetic enzyme
G6545_RS03230	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
G6545_RS03235	COG1012	belongs to the aldehyde dehydrogenase family
G6545_RS03240	COG1024	Enoyl-CoA hydratase
G6545_RS03245	COG2050	protein possibly involved in aromatic compounds catabolism
G6545_RS03255	COG3539	Fimbrial protein
G6545_RS03260	COG3539	Fimbrial protein
G6545_RS03265	COG3539	Fimbrial protein
G6545_RS03270	COG3539	Fimbrial protein
G6545_RS03275	COG3539	Fimbrial protein
G6545_RS03290	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
G6545_RS03295	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
G6545_RS03310	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
G6545_RS03315	COG3842	ATPase activity
G6545_RS03320	COG1176	ABC-type spermidine putrescine transport system, permease component I
G6545_RS03325	COG1177	transmembrane transport
G6545_RS03350	COG1960	acyl-CoA dehydrogenase activity
G6545_RS03360	COG0704	Plays a role in the regulation of phosphate uptake
G6545_RS03370	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
G6545_RS03375	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
G6545_RS03375	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
G6545_RS03380	COG1643	Atp-dependent helicase
G6545_RS03395	COG0438	transferase activity, transferring glycosyl groups
G6545_RS03400	COG0726	polysaccharide deacetylase
G6545_RS03405	COG0463	Glycosyl transferase, family 2
G6545_RS03410	COG0438	transferase activity, transferring glycosyl groups
G6545_RS03415	COG2194	sulfuric ester hydrolase activity
G6545_RS03440	COG0859	PFAM glycosyl transferase family 9
G6545_RS03445	COG1132	(ABC) transporter
G6545_RS03460	COG0077	Prephenate dehydratase
G6545_RS03465	COG1530	ribonuclease E activity
G6545_RS03505	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
G6545_RS03510	COG0799	negative regulation of ribosome biogenesis
G6545_RS03515	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
G6545_RS03525	COG0151	Belongs to the GarS family
G6545_RS03535	COG0433	COG0433 Predicted ATPase
G6545_RS03540	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
G6545_RS03550	COG1012	belongs to the aldehyde dehydrogenase family
G6545_RS03575	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
G6545_RS03585	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G6545_RS03595	COG0747	negative chemotaxis
G6545_RS03605	COG0473	3-isopropylmalate dehydrogenase activity
G6545_RS03610	COG2814	Major facilitator Superfamily
G6545_RS03615	COG1566	PFAM secretion protein HlyD family protein
G6545_RS03625	COG1846	Transcriptional regulator
G6545_RS03635	COG0697	spore germination
G6545_RS03645	COG0501	Belongs to the peptidase M48B family
G6545_RS03665	COG0583	DNA-binding transcription factor activity
G6545_RS03670	COG3842	ATPase activity
G6545_RS03675	COG1178	ABC-type Fe3 transport system permease component
G6545_RS03680	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
G6545_RS03685	COG1840	ABC-type Fe3 transport system, periplasmic component
G6545_RS03720	COG3181	Tripartite tricarboxylate transporter family receptor
G6545_RS03730	COG1722	exodeoxyribonuclease VII activity
G6545_RS03735	COG0142	geranyltranstransferase activity
G6545_RS03745	COG1469	GTP cyclohydrolase I activity
G6545_RS03750	COG0360	Binds together with S18 to 16S ribosomal RNA
G6545_RS03755	COG2965	DNA replication, synthesis of RNA primer
G6545_RS03760	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
G6545_RS03775	COG0305	Participates in initiation and elongation during chromosome replication
G6545_RS03785	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
G6545_RS03790	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
G6545_RS03795	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
G6545_RS03800	COG3737	Protein of unknown function (DUF498/DUF598)
G6545_RS03805	COG0436	Aminotransferase
G6545_RS03825	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
G6545_RS03830	COG0308	aminopeptidase N
G6545_RS03850	COG0312	modulator of DNA gyrase
G6545_RS03855	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
G6545_RS03865	COG0277	FAD linked oxidase domain protein
G6545_RS03870	COG0277	FAD linked oxidase domain protein
G6545_RS03880	COG0247	lactate metabolic process
G6545_RS03925	COG0583	DNA-binding transcription factor activity
G6545_RS03930	COG0482	sulfurtransferase activity
G6545_RS03935	COG0730	response to heat
G6545_RS03940	COG0625	glutathione transferase activity
G6545_RS03945	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
G6545_RS03950	COG3909	cytochrome
G6545_RS03980	COG3706	GGDEF domain
G6545_RS04015	COG1262	PFAM Formylglycine-generating sulfatase enzyme
G6545_RS04020	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
G6545_RS04030	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
G6545_RS04035	COG0069	glutamate synthase activity
G6545_RS04040	COG2391	methyltransferase activity
G6545_RS04045	COG0679	Auxin Efflux Carrier
G6545_RS04070	COG0557	exoribonuclease II activity
G6545_RS04075	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
G6545_RS04085	COG3128	pkhd-type hydroxylase
G6545_RS04090	COG0776	regulation of translation
G6545_RS04120	COG0642	Histidine kinase
G6545_RS04125	COG3158	transport of potassium into the cell
G6545_RS04135	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
G6545_RS04140	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
G6545_RS04150	COG0583	DNA-binding transcription factor activity
G6545_RS04160	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
G6545_RS04180	COG2186	Transcriptional regulator
G6545_RS04185	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
G6545_RS04205	COG0268	Binds directly to 16S ribosomal RNA
G6545_RS04215	COG0728	peptidoglycan biosynthetic process
G6545_RS04225	COG0563	adenylate kinase activity
G6545_RS04235	COG2835	tetraacyldisaccharide 4'-kinase activity
G6545_RS04245	COG0848	biopolymer transport protein
G6545_RS04250	COG0811	peptide transport
G6545_RS04260	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
G6545_RS04265	COG0038	chloride channel
G6545_RS04270	COG0183	Belongs to the thiolase family
G6545_RS04280	COG1278	Cold shock
G6545_RS04295	COG4953	penicillin-binding protein 1C
G6545_RS04300	COG0542	response to heat
G6545_RS04305	COG2995	paraquat-inducible protein a
G6545_RS04310	COG3008	intermembrane lipid transfer
G6545_RS04310	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
G6545_RS04320	COG0506	proline dehydrogenase activity
G6545_RS04320	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
G6545_RS04320	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
G6545_RS04350	COG2271	Major facilitator Superfamily
G6545_RS04355	COG1309	transcriptional regulator
G6545_RS04365	COG0004	ammonium transporteR
G6545_RS04385	COG0291	Belongs to the bacterial ribosomal protein bL35 family
G6545_RS04390	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
G6545_RS04395	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
G6545_RS04400	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G6545_RS04400	COG0072	phenylalanine-tRNA ligase activity
G6545_RS04435	COG0500	methyltransferase
G6545_RS04450	COG2367	Beta-lactamase
G6545_RS04460	COG1522	sequence-specific DNA binding
G6545_RS04475	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G6545_RS04510	COG0540	Belongs to the ATCase OTCase family
G6545_RS04515	COG2974	May be involved in recombination
G6545_RS04525	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G6545_RS04530	COG0583	DNA-binding transcription factor activity
G6545_RS04535	COG0183	Belongs to the thiolase family
G6545_RS04550	COG1028	Short-chain dehydrogenase reductase Sdr
G6545_RS04565	COG3842	ATPase activity
G6545_RS04570	COG1250	3-hydroxyacyl-CoA dehydrogenase
G6545_RS04570	COG1024	Enoyl-CoA hydratase
G6545_RS04580	COG0642	Histidine kinase
G6545_RS04590	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
G6545_RS04595	COG2137	regulation of response to DNA damage stimulus
G6545_RS04615	COG0045	succinate-CoA ligase (ADP-forming) activity
G6545_RS04620	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
G6545_RS04625	COG0861	Integral membrane protein TerC family
G6545_RS04630	COG0861	Integral membrane protein TerC family
G6545_RS04695	COG4964	Belongs to the GSP D family
G6545_RS04725	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
G6545_RS04735	COG1295	ribonuclease BN
G6545_RS04750	COG0745	RESPONSE REGULATOR receiver
G6545_RS04755	COG2205	protein histidine kinase activity
G6545_RS04760	COG3300	MHYT domain
G6545_RS04760	COG5001	Diguanylate cyclase
G6545_RS04765	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
G6545_RS04775	COG1763	Mo-molybdopterin cofactor biosynthetic process
G6545_RS04780	COG0303	'Molybdopterin
G6545_RS04785	COG0746	molybdenum cofactor guanylyltransferase activity
G6545_RS04790	COG0489	protein tyrosine kinase activity
G6545_RS04820	COG3383	formate dehydrogenase (NAD+) activity
G6545_RS04820	COG0243	molybdopterin cofactor binding
G6545_RS04825	COG0437	4 iron, 4 sulfur cluster binding
G6545_RS04855	COG1122	ATPase activity
G6545_RS04880	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
G6545_RS04895	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
G6545_RS04910	COG0135	phosphoribosylanthranilate isomerase activity
G6545_RS04955	COG0635	Involved in the biosynthesis of porphyrin-containing compound
G6545_RS04965	COG2197	response regulator
G6545_RS04970	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
G6545_RS04975	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
G6545_RS04990	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
G6545_RS04995	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
G6545_RS05005	COG1764	response to oxidative stress
G6545_RS05010	COG2423	ornithine cyclodeaminase activity
G6545_RS05020	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G6545_RS05025	COG0765	amino acid transport
G6545_RS05030	COG0765	amino acid transport
G6545_RS05035	COG1126	abc transporter atp-binding protein
G6545_RS05050	COG0586	Pfam SNARE associated Golgi protein
G6545_RS05060	COG1522	sequence-specific DNA binding
G6545_RS05070	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
G6545_RS05075	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
G6545_RS05080	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
G6545_RS05085	COG0196	riboflavin kinase activity
G6545_RS05090	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
G6545_RS05095	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
G6545_RS05095	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
G6545_RS05110	COG0210	DNA helicase
G6545_RS05115	COG4771	TonB-dependent receptor
G6545_RS05120	COG0488	(ABC) transporter
G6545_RS05125	COG2890	protein-(glutamine-N5) methyltransferase activity
G6545_RS05130	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
G6545_RS05135	COG2171	N-acyltransferase activity
G6545_RS05140	COG0436	Aminotransferase
G6545_RS05170	COG1278	Cold shock
G6545_RS05180	COG1278	Cold shock
G6545_RS05190	COG0544	peptidyl-prolyl cis-trans isomerase activity
G6545_RS05195	COG0740	serine-type endopeptidase activity
G6545_RS05210	COG0583	DNA-binding transcription factor activity
G6545_RS05215	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G6545_RS05230	COG1024	Enoyl-CoA hydratase
G6545_RS05240	COG0183	Belongs to the thiolase family
G6545_RS05245	COG1028	Short-chain dehydrogenase reductase Sdr
G6545_RS05250	COG1960	acyl-CoA dehydrogenase activity
G6545_RS05265	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
G6545_RS05275	COG3468	outer membrane autotransporter barrel domain protein
G6545_RS05280	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
G6545_RS05295	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
G6545_RS05305	COG1104	cysteine desulfurase activity
G6545_RS05310	COG0822	iron-sulfur transferase activity
G6545_RS05315	COG0316	Belongs to the HesB IscA family
G6545_RS05320	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
G6545_RS05325	COG0443	Heat shock 70 kDa protein
G6545_RS05330	COG0633	Ferredoxin
G6545_RS05345	COG1024	Enoyl-CoA hydratase
G6545_RS05375	COG1022	Amp-dependent synthetase and ligase
G6545_RS05390	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
G6545_RS05395	COG1028	Short-chain dehydrogenase reductase Sdr
G6545_RS05405	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
G6545_RS05420	COG1136	(ABC) transporter
G6545_RS05425	COG0084	hydrolase, TatD family'
G6545_RS05440	COG2333	competence protein COMEC
G6545_RS05440	COG0658	competence protein
G6545_RS05450	COG0613	PHP domain protein
G6545_RS05460	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
G6545_RS05470	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
G6545_RS05475	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
G6545_RS05475	COG0047	phosphoribosylformylglycinamidine synthase activity
G6545_RS05480	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
G6545_RS05480	COG3210	domain, Protein
G6545_RS05480	COG3064	Membrane
G6545_RS05500	COG3181	Tripartite tricarboxylate transporter family receptor
G6545_RS05515	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G6545_RS05530	COG2197	response regulator
G6545_RS05550	COG0519	Catalyzes the synthesis of GMP from XMP
G6545_RS05550	COG0518	GMP synthase (glutamine-hydrolyzing) activity
G6545_RS05565	COG0477	Major facilitator Superfamily
G6545_RS05570	COG2814	Major facilitator Superfamily
G6545_RS05585	COG1414	Transcriptional regulator
G6545_RS05590	COG1228	amidohydrolase
G6545_RS05600	COG1116	anion transmembrane transporter activity
G6545_RS05605	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G6545_RS05630	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
G6545_RS05645	COG3618	amidohydrolase
G6545_RS05655	COG3181	Tripartite tricarboxylate transporter family receptor
G6545_RS05680	COG2079	MmgE PrpD family protein
G6545_RS05685	COG1012	belongs to the aldehyde dehydrogenase family
G6545_RS05710	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
G6545_RS05750	COG0747	negative chemotaxis
G6545_RS05755	COG0601	transmembrane transport
G6545_RS05765	COG4172	Belongs to the ABC transporter superfamily
G6545_RS05770	COG1609	Transcriptional regulator
G6545_RS05785	COG0789	Transcriptional regulator
G6545_RS05810	COG2188	Transcriptional regulator
G6545_RS05815	COG3181	Tripartite tricarboxylate transporter family receptor
G6545_RS05835	COG1802	Transcriptional regulator
G6545_RS05850	COG0842	Transport permease protein
G6545_RS05855	COG0842	Transport permease protein
G6545_RS05860	COG1131	(ABC) transporter
G6545_RS05880	COG0656	L-ascorbic acid biosynthetic process
G6545_RS05885	COG3284	Transcriptional regulator
G6545_RS05890	COG1012	belongs to the aldehyde dehydrogenase family
G6545_RS05905	COG2733	membrane
G6545_RS05910	COG0583	DNA-binding transcription factor activity
G6545_RS05915	COG0384	phenazine biosynthesis protein PhzF
G6545_RS05920	COG5507	3-demethylubiquinone-9 3-methyltransferase
G6545_RS05925	COG2169	Transcriptional regulator
G6545_RS05955	COG0659	secondary active sulfate transmembrane transporter activity
G6545_RS05980	COG1132	(ABC) transporter
G6545_RS06020	COG2207	Transcriptional regulator
G6545_RS06055	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
G6545_RS06060	COG1280	lysine exporter protein (LysE YggA)
G6545_RS06080	COG0625	glutathione transferase activity
G6545_RS06095	COG0697	spore germination
G6545_RS06110	COG0534	Mate efflux family protein
G6545_RS06115	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
G6545_RS06130	COG3246	L-lysine catabolic process to acetate
G6545_RS06135	COG1250	3-hydroxyacyl-CoA dehydrogenase
G6545_RS06140	COG0583	DNA-binding transcription factor activity
G6545_RS06155	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
G6545_RS06160	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
G6545_RS06165	COG3622	Belongs to the hyi family
G6545_RS06175	COG0129	dihydroxy-acid dehydratase activity
G6545_RS06190	COG0129	dihydroxy-acid dehydratase activity
G6545_RS06195	COG3181	Tripartite tricarboxylate transporter family receptor
G6545_RS06205	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
G6545_RS06220	COG2188	Transcriptional regulator
G6545_RS06230	COG0583	DNA-binding transcription factor activity
G6545_RS06240	COG0501	Belongs to the peptidase M48B family
G6545_RS06250	COG2814	Major facilitator Superfamily
G6545_RS06255	COG0583	DNA-binding transcription factor activity
G6545_RS06290	COG4691	Plasmid stability protein
G6545_RS06320	COG2837	iron assimilation
G6545_RS06345	COG1335	isochorismatase
G6545_RS06405	COG2346	COG2346, Truncated hemoglobins
G6545_RS06415	COG1126	abc transporter atp-binding protein
G6545_RS06425	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G6545_RS06435	COG0789	Transcriptional regulator
G6545_RS06445	COG0165	Argininosuccinate lyase
G6545_RS06450	COG0668	transmembrane transport
G6545_RS06495	COG0747	negative chemotaxis
G6545_RS06500	COG0601	transmembrane transport
G6545_RS06510	COG4172	Belongs to the ABC transporter superfamily
G6545_RS06515	COG1280	lysine exporter protein (LysE YggA)
G6545_RS06525	COG2814	Major facilitator Superfamily
G6545_RS06530	COG3161	chorismate lyase activity
G6545_RS06535	COG1187	pseudouridine synthase activity
G6545_RS06545	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G6545_RS06565	COG1999	signal sequence binding
G6545_RS06570	COG0339	signal peptide processing
G6545_RS06575	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
G6545_RS06580	COG4566	intracellular signal transduction
G6545_RS06590	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
G6545_RS06595	COG0508	dehydrogenase complex catalyzes the overall conversion of
G6545_RS06600	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
G6545_RS06605	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
G6545_RS06635	COG0745	RESPONSE REGULATOR receiver
G6545_RS06640	COG2198	Histidine kinase
G6545_RS06640	COG0643	Histidine kinase
G6545_RS06650	COG0840	transmembrane signaling receptor activity
G6545_RS06655	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
G6545_RS06660	COG2201	protein-glutamate methylesterase activity
G6545_RS06665	COG0745	RESPONSE REGULATOR receiver
G6545_RS06670	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
G6545_RS06705	COG1815	bacterial-type flagellum-dependent cell motility
G6545_RS06710	COG1558	bacterial-type flagellum-dependent cell motility
G6545_RS06720	COG1749	Flagellar hook protein flgE
G6545_RS06735	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
G6545_RS06750	COG1256	bacterial-type flagellum assembly
G6545_RS06760	COG0840	transmembrane signaling receptor activity
G6545_RS06765	COG0840	transmembrane signaling receptor activity
G6545_RS06775	COG0840	transmembrane signaling receptor activity
G6545_RS06780	COG0840	transmembrane signaling receptor activity
G6545_RS06795	COG1338	Plays a role in the flagellum-specific transport system
G6545_RS06805	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
G6545_RS06815	COG1580	Controls the rotational direction of flagella during chemotaxis
G6545_RS06830	COG1157	protein secretion by the type III secretion system
G6545_RS06840	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
G6545_RS06850	COG1677	Flagellar hook-basal body complex protein FliE
G6545_RS06860	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
G6545_RS06890	COG0285	dihydrofolate synthase activity
G6545_RS06920	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
G6545_RS06925	COG0024	Methionine aminopeptidase
G6545_RS06930	COG0052	Belongs to the universal ribosomal protein uS2 family
G6545_RS06935	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
G6545_RS06940	COG0528	UMP kinase activity
G6545_RS06945	COG0233	cytoplasmic translational termination
G6545_RS06950	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
G6545_RS06960	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
G6545_RS06965	COG0750	zinc metalloprotease
G6545_RS06970	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
G6545_RS06975	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
G6545_RS06980	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
G6545_RS06985	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
G6545_RS07000	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
G6545_RS07005	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
G6545_RS07020	COG0519	Catalyzes the synthesis of GMP from XMP
G6545_RS07020	COG0518	GMP synthase (glutamine-hydrolyzing) activity
G6545_RS07030	COG0330	HflC and HflK could
G6545_RS07035	COG3706	GGDEF domain
G6545_RS07040	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
G6545_RS07045	COG2867	negative regulation of translational initiation
G6545_RS07055	COG1960	acyl-CoA dehydrogenase activity
G6545_RS07060	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
G6545_RS07085	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
G6545_RS07090	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
G6545_RS07095	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
G6545_RS07100	COG0084	hydrolase, TatD family'
G6545_RS07115	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G6545_RS07125	COG1126	abc transporter atp-binding protein
G6545_RS07130	COG0010	Belongs to the arginase family
G6545_RS07135	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
G6545_RS07150	COG0028	Belongs to the TPP enzyme family
G6545_RS07170	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
G6545_RS07180	COG3189	MarR family transcriptional regulator
G6545_RS07190	COG2985	domain, Protein
G6545_RS07195	COG0076	glutamate decarboxylase activity
G6545_RS07210	COG1595	DNA-templated transcription, initiation
G6545_RS07220	COG0861	Integral membrane protein TerC family
G6545_RS07245	COG2988	succinylglutamate desuccinylase activity
G6545_RS07260	COG1253	flavin adenine dinucleotide binding
G6545_RS07270	COG3181	Tripartite tricarboxylate transporter family receptor
G6545_RS07275	COG2084	Dehydrogenase
G6545_RS07290	COG1619	proteins homologs of microcin C7 resistance protein MccF
G6545_RS07300	COG2814	Major facilitator Superfamily
G6545_RS07310	COG0583	DNA-binding transcription factor activity
G6545_RS07320	COG3181	Tripartite tricarboxylate transporter family receptor
G6545_RS07335	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G6545_RS07340	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
G6545_RS07345	COG0439	Biotin carboxylase
G6545_RS07365	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G6545_RS07380	COG0395	ABC-type sugar transport system, permease component
G6545_RS07385	COG1176	ABC-type spermidine putrescine transport system, permease component I
G6545_RS07395	COG3842	ATPase activity
G6545_RS07400	COG1414	Transcriptional regulator
G6545_RS07405	COG1028	Short-chain dehydrogenase reductase Sdr
G6545_RS07415	COG2188	Transcriptional regulator
G6545_RS07440	COG3181	Tripartite tricarboxylate transporter family receptor
G6545_RS07445	COG0583	DNA-binding transcription factor activity
G6545_RS07465	COG1172	Belongs to the binding-protein-dependent transport system permease family
G6545_RS07475	COG0179	Fumarylacetoacetate (FAA) hydrolase
G6545_RS07485	COG1228	amidohydrolase
G6545_RS07515	COG0861	Integral membrane protein TerC family
G6545_RS07520	COG1028	Short-chain dehydrogenase reductase Sdr
G6545_RS07535	COG1262	PFAM Formylglycine-generating sulfatase enzyme
G6545_RS07540	COG0714	Associated with various cellular activities
G6545_RS07575	COG3119	arylsulfatase activity
G6545_RS07595	COG2197	response regulator
G6545_RS07605	COG2944	sequence-specific DNA binding
G6545_RS07610	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
G6545_RS07615	COG0625	glutathione transferase activity
G6545_RS07640	COG1304	FMN binding
G6545_RS07645	COG0179	Fumarylacetoacetate (FAA) hydrolase
G6545_RS07650	COG1028	Short-chain dehydrogenase reductase Sdr
G6545_RS07675	COG3119	arylsulfatase activity
G6545_RS07685	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G6545_RS07690	COG1902	pentaerythritol trinitrate reductase activity
G6545_RS07700	COG0583	DNA-binding transcription factor activity
G6545_RS07740	COG1309	transcriptional regulator
G6545_RS07745	COG1414	Transcriptional regulator
G6545_RS07750	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G6545_RS07755	COG0183	Belongs to the thiolase family
G6545_RS07770	COG1028	Short-chain dehydrogenase reductase Sdr
G6545_RS07775	COG0583	DNA-binding transcription factor activity
G6545_RS07780	COG3181	Tripartite tricarboxylate transporter family receptor
G6545_RS07785	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G6545_RS07790	COG1024	Enoyl-CoA hydratase
G6545_RS07800	COG3181	Tripartite tricarboxylate transporter family receptor
G6545_RS07805	COG1250	3-hydroxyacyl-CoA dehydrogenase
G6545_RS07805	COG1024	Enoyl-CoA hydratase
G6545_RS07810	COG0183	Belongs to the thiolase family
G6545_RS07815	COG1454	alcohol dehydrogenase
G6545_RS07820	COG0824	Thioesterase
G6545_RS07840	COG0583	DNA-binding transcription factor activity
G6545_RS07845	COG0431	NADPH-dependent FMN reductase
G6545_RS07875	COG1028	Short-chain dehydrogenase reductase Sdr
G6545_RS07880	COG0583	DNA-binding transcription factor activity
G6545_RS07890	COG5001	Diguanylate cyclase
G6545_RS07890	COG3706	GGDEF domain
G6545_RS07890	COG4251	negative regulation of phosphorylation
G6545_RS07890	COG2203	Gaf domain
G6545_RS07895	COG1454	alcohol dehydrogenase
G6545_RS07895	COG1012	belongs to the aldehyde dehydrogenase family
G6545_RS07905	COG0330	HflC and HflK could
G6545_RS07920	COG0765	amino acid transport
G6545_RS07945	COG3043	anaerobic respiration
G6545_RS07950	COG3005	denitrification pathway
G6545_RS07955	COG4133	protoheme IX ABC transporter activity
G6545_RS07975	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
G6545_RS07985	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G6545_RS08015	COG4948	Mandelate Racemase Muconate Lactonizing
G6545_RS08020	COG3181	Tripartite tricarboxylate transporter family receptor
G6545_RS08025	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
G6545_RS08030	COG0066	3-isopropylmalate dehydratase activity
G6545_RS08045	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G6545_RS08055	COG3181	Tripartite tricarboxylate transporter family receptor
G6545_RS08065	COG1802	Transcriptional regulator
G6545_RS08080	COG0583	DNA-binding transcription factor activity
G6545_RS08090	COG3468	outer membrane autotransporter barrel domain protein
G6545_RS08100	COG1695	Transcriptional regulator
G6545_RS08110	COG3568	Endonuclease Exonuclease Phosphatase
G6545_RS08115	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
G6545_RS08120	COG0392	lysyltransferase activity
G6545_RS08155	COG4575	ribosome binding
G6545_RS08160	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
G6545_RS08170	COG1028	Short-chain dehydrogenase reductase Sdr
G6545_RS08220	COG0028	Belongs to the TPP enzyme family
G6545_RS08230	COG2204	response regulator
G6545_RS08235	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
G6545_RS08245	COG0297	glycogen (starch) synthase activity
G6545_RS08250	COG0366	Alpha amylase catalytic
G6545_RS08260	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
G6545_RS08270	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
G6545_RS08275	COG1640	4-alpha-glucanotransferase
G6545_RS08320	COG0667	Aldo Keto reductase
G6545_RS08335	COG2259	Doxx family
G6545_RS08355	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G6545_RS08375	COG0386	Belongs to the glutathione peroxidase family
G6545_RS08380	COG0625	glutathione transferase activity
G6545_RS08405	COG0688	phosphatidylethanolamine metabolic process
G6545_RS08415	COG1464	Belongs to the NlpA lipoprotein family
G6545_RS08430	COG2363	Small membrane protein
G6545_RS08435	COG0697	spore germination
G6545_RS08445	COG2133	pyrroloquinoline quinone binding
G6545_RS08450	COG0625	glutathione transferase activity
G6545_RS08455	COG1794	racemase activity, acting on amino acids and derivatives
G6545_RS08475	COG0559	Belongs to the binding-protein-dependent transport system permease family
G6545_RS08485	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
G6545_RS08495	COG1653	transport
G6545_RS08500	COG1175	transmembrane transport
G6545_RS08505	COG0395	ABC-type sugar transport system, permease component
G6545_RS08510	COG3842	ATPase activity
G6545_RS08525	COG1028	Short-chain dehydrogenase reductase Sdr
G6545_RS08525	COG3321	synthase
G6545_RS08525	COG0604	alcohol dehydrogenase
G6545_RS08530	COG0156	8-amino-7-oxononanoate synthase activity
G6545_RS08540	COG0300	oxidoreductase activity
G6545_RS08560	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
G6545_RS08575	COG0438	transferase activity, transferring glycosyl groups
G6545_RS08595	COG0463	Glycosyl transferase, family 2
G6545_RS08610	COG0783	Belongs to the Dps family
G6545_RS08625	COG0583	DNA-binding transcription factor activity
G6545_RS08630	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
G6545_RS08645	COG0656	L-ascorbic acid biosynthetic process
G6545_RS08650	COG2814	Major facilitator Superfamily
G6545_RS08655	COG0583	DNA-binding transcription factor activity
G6545_RS08665	COG1840	ABC-type Fe3 transport system, periplasmic component
G6545_RS08670	COG1178	ABC-type Fe3 transport system permease component
G6545_RS08675	COG3842	ATPase activity
G6545_RS08680	COG1741	Belongs to the pirin family
G6545_RS08685	COG1741	Belongs to the pirin family
G6545_RS08690	COG0583	DNA-binding transcription factor activity
G6545_RS08695	COG2204	response regulator
G6545_RS08705	COG0174	glutamine synthetase
G6545_RS08710	COG0635	Involved in the biosynthesis of porphyrin-containing compound
G6545_RS08715	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
G6545_RS08720	COG5001	Diguanylate cyclase
G6545_RS08720	COG5002	protein histidine kinase activity
G6545_RS08740	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
G6545_RS08745	COG1561	YicC-like family, N-terminal region
G6545_RS08760	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
G6545_RS08765	COG0791	NLP P60 protein
G6545_RS08770	COG1028	Short-chain dehydrogenase reductase Sdr
G6545_RS08775	COG2863	cytochrome
G6545_RS08780	COG3258	Cytochrome c
G6545_RS08785	COG0194	GDP metabolic process
G6545_RS08790	COG1758	RNA polymerase activity
G6545_RS08795	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
G6545_RS08800	COG1126	abc transporter atp-binding protein
G6545_RS08805	COG0765	amino acid transport
G6545_RS08810	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G6545_RS08830	COG0583	DNA-binding transcription factor activity
G6545_RS08855	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
G6545_RS08870	COG2831	hemolysin activation secretion protein
G6545_RS08875	COG3539	Fimbrial protein
G6545_RS08880	COG3188	usher protein
G6545_RS08885	COG3121	Chaperone
G6545_RS08895	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
G6545_RS08895	COG3210	domain, Protein
G6545_RS08895	COG3064	Membrane
G6545_RS08900	COG2197	response regulator
G6545_RS08905	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G6545_RS08905	COG2205	protein histidine kinase activity
G6545_RS08915	COG4336	lyase activity
G6545_RS08930	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
G6545_RS08955	COG4181	ATPase activity
G6545_RS08965	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
G6545_RS08970	COG0584	glycerophosphoryl diester phosphodiesterase
G6545_RS08975	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
G6545_RS08985	COG0678	peroxiredoxin activity
G6545_RS08985	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
G6545_RS08995	COG0789	Transcriptional regulator
G6545_RS09000	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
G6545_RS09035	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
G6545_RS09040	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
G6545_RS09045	COG2252	PERMEase
G6545_RS09050	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G6545_RS09055	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G6545_RS09085	COG0488	(ABC) transporter
G6545_RS09090	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
G6545_RS09100	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
G6545_RS09105	COG1024	Enoyl-CoA hydratase
G6545_RS09110	COG1619	proteins homologs of microcin C7 resistance protein MccF
G6545_RS09115	COG0590	tRNA wobble adenosine to inosine editing
G6545_RS09135	COG2212	antiporter activity
G6545_RS09140	COG1863	multisubunit Na H antiporter MnhE subunit
G6545_RS09145	COG0651	ATP synthesis coupled electron transport
G6545_RS09150	COG1006	Multisubunit Na H antiporter MnhC subunit
G6545_RS09155	COG2111	Na H antiporter
G6545_RS09155	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
G6545_RS09160	COG3181	Tripartite tricarboxylate transporter family receptor
G6545_RS09170	COG0420	3'-5' exonuclease activity
G6545_RS09175	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G6545_RS09205	COG0395	ABC-type sugar transport system, permease component
G6545_RS09215	COG3842	ATPase activity
G6545_RS09245	COG3181	Tripartite tricarboxylate transporter family receptor
G6545_RS09280	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
G6545_RS09305	COG0602	queuosine metabolic process
G6545_RS09310	COG0720	synthase
G6545_RS09315	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
G6545_RS09320	COG0235	Class ii aldolase
G6545_RS09345	COG1566	PFAM secretion protein HlyD family protein
G6545_RS09355	COG0400	carboxylic ester hydrolase activity
G6545_RS09370	COG0587	DNA-directed DNA polymerase activity
G6545_RS09375	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G6545_RS09380	COG1959	2 iron, 2 sulfur cluster binding
G6545_RS09420	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
G6545_RS09435	COG0667	Aldo Keto reductase
G6545_RS09445	COG5265	(ABC) transporter
G6545_RS09485	COG3468	outer membrane autotransporter barrel domain protein
G6545_RS09510	COG5001	Diguanylate cyclase
G6545_RS09510	COG5002	protein histidine kinase activity
G6545_RS09510	COG3447	MASE1 domain protein
G6545_RS09515	COG0840	transmembrane signaling receptor activity
G6545_RS09520	COG4943	cyclic-guanylate-specific phosphodiesterase activity
G6545_RS09525	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G6545_RS09540	COG0833	amino acid
G6545_RS09570	COG3829	transcription factor binding
G6545_RS09580	COG4943	cyclic-guanylate-specific phosphodiesterase activity
G6545_RS09595	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G6545_RS09600	COG1012	belongs to the aldehyde dehydrogenase family
G6545_RS09605	COG0028	Belongs to the TPP enzyme family
G6545_RS09620	COG0583	DNA-binding transcription factor activity
G6545_RS09625	COG4692	amylo-alpha-1,6-glucosidase activity
G6545_RS09635	COG0183	Belongs to the thiolase family
G6545_RS09650	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G6545_RS09655	COG0633	Ferredoxin
G6545_RS09665	COG1024	Enoyl-CoA hydratase
G6545_RS09675	COG4638	Rieske (2fe-2S)
G6545_RS09685	COG0559	Belongs to the binding-protein-dependent transport system permease family
G6545_RS09735	COG4680	protein conserved in bacteria
G6545_RS09745	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
G6545_RS09755	COG0828	Belongs to the bacterial ribosomal protein bS21 family
G6545_RS09765	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
G6545_RS09775	COG0330	HflC and HflK could
G6545_RS09780	COG0330	HflC and HflK could
G6545_RS09785	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
G6545_RS09790	COG1923	regulation of RNA biosynthetic process
G6545_RS09800	COG1160	GTP binding
G6545_RS09805	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
G6545_RS09810	COG2976	Protein conserved in bacteria
G6545_RS09830	COG0820	rRNA (adenine-C2-)-methyltransferase activity
G6545_RS09835	COG0105	UTP biosynthetic process
G6545_RS09840	COG0525	valine-tRNA ligase activity
G6545_RS09850	COG0745	RESPONSE REGULATOR receiver
G6545_RS09855	COG0642	Histidine kinase
G6545_RS09865	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
G6545_RS09880	COG0228	four-way junction DNA binding
G6545_RS09890	COG0425	Belongs to the sulfur carrier protein TusA family
G6545_RS09895	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
G6545_RS09945	COG4172	Belongs to the ABC transporter superfamily
G6545_RS09950	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G6545_RS09955	COG0601	transmembrane transport
G6545_RS09960	COG0747	negative chemotaxis
G6545_RS09985	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G6545_RS10010	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
G6545_RS10015	COG3395	kinase activity
G6545_RS10025	COG5285	phytanoyl-CoA dioxygenase
G6545_RS10040	COG0456	acetyltransferase
G6545_RS10055	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
G6545_RS10060	COG2358	TRAP transporter, solute receptor (TAXI family
G6545_RS10070	COG2311	Membrane
G6545_RS10095	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
G6545_RS10105	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
G6545_RS10110	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
G6545_RS10115	COG1760	l-serine dehydratase
G6545_RS10120	COG1283	sodium-dependent phosphate transmembrane transporter activity
G6545_RS10125	COG0412	Dienelactone hydrolase
G6545_RS10140	COG1611	Belongs to the LOG family
G6545_RS10160	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
G6545_RS10165	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
G6545_RS10170	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
G6545_RS10175	COG2251	uridine kinase activity
G6545_RS10175	COG0195	Participates in both transcription termination and antitermination
G6545_RS10180	COG0779	Required for maturation of 30S ribosomal subunits
G6545_RS10185	COG1187	pseudouridine synthase activity
G6545_RS10190	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
G6545_RS10200	COG0583	DNA-binding transcription factor activity
G6545_RS10210	COG0523	cobalamin synthesis protein
G6545_RS10230	COG0625	glutathione transferase activity
G6545_RS10235	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
G6545_RS10240	COG1047	Peptidyl-prolyl cis-trans
G6545_RS10245	COG2003	Belongs to the UPF0758 family
G6545_RS10250	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
G6545_RS10255	COG3483	tryptophan 2,3-dioxygenase activity
G6545_RS10290	COG2304	oxidoreductase activity
G6545_RS10305	COG1028	Short-chain dehydrogenase reductase Sdr
G6545_RS10310	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
G6545_RS10315	COG1562	ergosterol biosynthetic process
G6545_RS10320	COG1562	ergosterol biosynthetic process
G6545_RS10325	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
G6545_RS10325	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
G6545_RS10330	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
G6545_RS10340	COG0842	Transport permease protein
G6545_RS10345	COG1131	(ABC) transporter
G6545_RS10365	COG1477	protein flavinylation
G6545_RS10380	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
G6545_RS10395	COG5564	TIM-barrel signal transduction protein
G6545_RS10400	COG5441	Belongs to the UPF0261 family
G6545_RS10410	COG3468	outer membrane autotransporter barrel domain protein
G6545_RS10420	COG3468	outer membrane autotransporter barrel domain protein
G6545_RS10425	COG0542	response to heat
G6545_RS10430	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
G6545_RS10445	COG0494	nUDIX hydrolase
G6545_RS10450	COG3530	Putative quorum-sensing-regulated virulence factor
G6545_RS10460	COG1595	DNA-templated transcription, initiation
G6545_RS10465	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
G6545_RS10500	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G6545_RS10505	COG0765	amino acid transport
G6545_RS10510	COG0765	amino acid transport
G6545_RS10540	COG2841	Protein conserved in bacteria
G6545_RS10545	COG2814	Major facilitator Superfamily
G6545_RS10560	COG0628	permease
G6545_RS10565	COG0842	Transport permease protein
G6545_RS10570	COG1131	(ABC) transporter
G6545_RS10615	COG3278	Belongs to the heme-copper respiratory oxidase family
G6545_RS10635	COG0156	8-amino-7-oxononanoate synthase activity
G6545_RS10645	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
G6545_RS10645	COG4106	trans-aconitate 2-methyltransferase activity
G6545_RS10650	COG1380	Effector of murein hydrolase LrgA
G6545_RS10655	COG1346	cytolysis
G6545_RS10665	COG2224	Isocitrate lyase
G6545_RS10670	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
G6545_RS10670	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
G6545_RS10680	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
G6545_RS10695	COG0736	holo-[acyl-carrier-protein] synthase activity
G6545_RS10700	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
G6545_RS10710	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G6545_RS10715	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G6545_RS10740	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
G6545_RS10755	COG2032	superoxide dismutase activity
G6545_RS10765	COG0318	PFAM AMP-dependent synthetase and ligase
G6545_RS10770	COG1024	Enoyl-CoA hydratase
G6545_RS10780	COG1802	Transcriptional regulator
G6545_RS10790	COG0183	Belongs to the thiolase family
G6545_RS10795	COG1942	4-Oxalocrotonate Tautomerase
G6545_RS10805	COG4176	ABC-type proline glycine betaine transport system permease component
G6545_RS10815	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
G6545_RS10820	COG2814	Major facilitator Superfamily
G6545_RS10825	COG0227	Belongs to the bacterial ribosomal protein bL28 family
G6545_RS10830	COG0267	Belongs to the bacterial ribosomal protein bL33 family
G6545_RS10850	COG2814	Major facilitator Superfamily
G6545_RS10855	COG0495	leucyl-tRNA aminoacylation
G6545_RS10870	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
G6545_RS10880	COG0154	amidase activity
G6545_RS10885	COG1250	3-hydroxyacyl-CoA dehydrogenase
G6545_RS10895	COG3012	SEC-C Motif Domain Protein
G6545_RS10935	COG0385	Bile acid
G6545_RS10940	COG0427	acetyl-CoA hydrolase
G6545_RS10945	COG0583	DNA-binding transcription factor activity
G6545_RS10950	COG3264	Mechanosensitive ion channel
G6545_RS10950	COG1511	domain protein
G6545_RS10965	COG0730	response to heat
G6545_RS10970	COG0697	spore germination
G6545_RS11005	COG2885	chlorophyll binding
G6545_RS11025	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
G6545_RS11030	COG3384	dioxygenase
G6545_RS11045	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
G6545_RS11050	COG3474	cytochrome
G6545_RS11115	COG4964	Belongs to the GSP D family
G6545_RS11160	COG1846	Transcriptional regulator
G6545_RS11165	COG4172	Belongs to the ABC transporter superfamily
G6545_RS11170	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G6545_RS11175	COG0601	transmembrane transport
G6545_RS11180	COG0747	negative chemotaxis
G6545_RS11190	COG0598	Magnesium transport protein CorA
G6545_RS11195	COG0210	DNA helicase
G6545_RS11210	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
G6545_RS11220	COG0483	inositol monophosphate 1-phosphatase activity
G6545_RS11225	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
G6545_RS11235	COG1045	serine acetyltransferase
G6545_RS11240	COG0166	Belongs to the GPI family
G6545_RS11255	COG2197	response regulator
G6545_RS11270	COG0183	Belongs to the thiolase family
G6545_RS11285	COG1250	3-hydroxyacyl-CoA dehydrogenase
G6545_RS11285	COG1024	Enoyl-CoA hydratase
G6545_RS11290	COG0183	Belongs to the thiolase family
G6545_RS11300	COG0318	PFAM AMP-dependent synthetase and ligase
G6545_RS11310	COG3181	Tripartite tricarboxylate transporter family receptor
G6545_RS11325	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
G6545_RS11325	COG1017	nitric oxide dioxygenase activity
G6545_RS11330	COG2010	Cytochrome c
G6545_RS11330	COG1529	Aldehyde oxidase and xanthine dehydrogenase
G6545_RS11335	COG1335	isochorismatase
G6545_RS11340	COG2309	aminopeptidase activity
G6545_RS11345	COG0596	Alpha beta hydrolase
G6545_RS11350	COG3473	Maleate cis-trans isomerase
G6545_RS11355	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
G6545_RS11360	COG2080	2 iron, 2 sulfur cluster binding
G6545_RS11365	COG2010	Cytochrome c
G6545_RS11365	COG1529	Aldehyde oxidase and xanthine dehydrogenase
G6545_RS11390	COG1846	Transcriptional regulator
G6545_RS11410	COG1649	PFAM Uncharacterised BCR, COG1649
G6545_RS11410	COG0726	polysaccharide deacetylase
G6545_RS11415	COG1215	transferase activity, transferring glycosyl groups
G6545_RS11425	COG1902	pentaerythritol trinitrate reductase activity
G6545_RS11450	COG0251	oxidation-reduction process
G6545_RS11460	COG1832	CoA-binding protein
G6545_RS11465	COG1414	Transcriptional regulator
G6545_RS11470	COG0446	pyridine nucleotide-disulphide oxidoreductase
G6545_RS11470	COG1902	pentaerythritol trinitrate reductase activity
G6545_RS11480	COG3842	ATPase activity
G6545_RS11505	COG0583	DNA-binding transcription factor activity
G6545_RS11515	COG1028	Short-chain dehydrogenase reductase Sdr
G6545_RS11525	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
G6545_RS11540	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
G6545_RS11545	COG1250	3-hydroxyacyl-CoA dehydrogenase
G6545_RS11565	COG0527	aspartate kinase activity
G6545_RS11570	COG0037	tRNA processing
G6545_RS11575	COG0825	malonyl-CoA metabolic process
G6545_RS11590	COG3063	Type IV pilus biogenesis stability protein PilW
G6545_RS11610	COG1253	flavin adenine dinucleotide binding
G6545_RS11635	COG0668	transmembrane transport
G6545_RS11670	COG3360	Dodecin
G6545_RS11680	COG2850	peptidyl-arginine hydroxylation
G6545_RS11690	COG3539	Fimbrial protein
G6545_RS11695	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
G6545_RS11700	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
G6545_RS11705	COG1994	Peptidase M50
G6545_RS11710	COG0009	L-threonylcarbamoyladenylate synthase
G6545_RS11715	COG2321	neutral zinc metallopeptidase
G6545_RS11760	COG1366	Belongs to the anti-sigma-factor antagonist family
G6545_RS11765	COG2172	sigma factor antagonist activity
G6545_RS11770	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
G6545_RS11780	COG2208	phosphoserine phosphatase activity
G6545_RS11780	COG2770	Histidine kinase
G6545_RS11800	COG1595	DNA-templated transcription, initiation
G6545_RS11815	COG4792	protein secretion
G6545_RS11820	COG4791	protein targeting
G6545_RS11825	COG4794	Type iii secretion
G6545_RS11830	COG4790	Type iii secretion
G6545_RS11865	COG4669	(LipO)protein
G6545_RS11930	COG4789	Type iii secretion
G6545_RS11960	COG1902	pentaerythritol trinitrate reductase activity
G6545_RS11965	COG0251	oxidation-reduction process
G6545_RS12005	COG1028	Short-chain dehydrogenase reductase Sdr
G6545_RS12015	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
G6545_RS12055	COG0179	Fumarylacetoacetate (FAA) hydrolase
G6545_RS12070	COG0583	DNA-binding transcription factor activity
G6545_RS12075	COG3971	2-oxopent-4-enoate hydratase activity
G6545_RS12105	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
G6545_RS12120	COG0511	ligase activity, forming carbon-carbon bonds
G6545_RS12130	COG0439	Biotin carboxylase
G6545_RS12135	COG2188	Transcriptional regulator
G6545_RS12160	COG0511	ligase activity, forming carbon-carbon bonds
G6545_RS12170	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
G6545_RS12180	COG1012	belongs to the aldehyde dehydrogenase family
G6545_RS12190	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
G6545_RS12215	COG1132	(ABC) transporter
G6545_RS12225	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
G6545_RS12265	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
G6545_RS12300	COG0583	DNA-binding transcription factor activity
G6545_RS12305	COG2985	domain, Protein
G6545_RS12320	COG3181	Tripartite tricarboxylate transporter family receptor
G6545_RS12350	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
G6545_RS12365	COG1126	abc transporter atp-binding protein
G6545_RS12370	COG0765	amino acid transport
G6545_RS12375	COG4597	amino acid ABC transporter
G6545_RS12380	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G6545_RS12385	COG1473	amidohydrolase
G6545_RS12390	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
G6545_RS12395	COG1522	sequence-specific DNA binding
G6545_RS12415	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
G6545_RS12420	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
G6545_RS12425	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
G6545_RS12430	COG1028	Short-chain dehydrogenase reductase Sdr
G6545_RS12435	COG1028	Short-chain dehydrogenase reductase Sdr
G6545_RS12450	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G6545_RS12455	COG0154	amidase activity
G6545_RS12465	COG1137	ATPase activity
G6545_RS12495	COG1250	3-hydroxyacyl-CoA dehydrogenase
G6545_RS12500	COG2072	flavoprotein involved in K transport
G6545_RS12535	COG0559	Belongs to the binding-protein-dependent transport system permease family
G6545_RS12565	COG0559	Belongs to the binding-protein-dependent transport system permease family
G6545_RS12625	COG3620	sequence-specific DNA binding
G6545_RS12630	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G6545_RS12640	COG3181	Tripartite tricarboxylate transporter family receptor
G6545_RS12680	COG0248	Ppx GppA phosphatase
G6545_RS12700	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
G6545_RS12710	COG1534	Rna-binding protein
G6545_RS12715	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
G6545_RS12720	COG0840	transmembrane signaling receptor activity
G6545_RS12725	COG2233	PERMEase
G6545_RS12745	COG3842	ATPase activity
G6545_RS12755	COG0406	alpha-ribazole phosphatase activity
G6545_RS12760	COG4221	oxidoreductase activity
G6545_RS12765	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
G6545_RS12770	COG0505	Belongs to the CarA family
G6545_RS12780	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G6545_RS12790	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
G6545_RS12795	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G6545_RS12810	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
G6545_RS12820	COG1074	ATP-dependent DNA helicase activity
G6545_RS12835	COG2814	Major facilitator Superfamily
G6545_RS12845	COG1686	Belongs to the peptidase S11 family
G6545_RS12855	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
G6545_RS12860	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
G6545_RS12865	COG4974	Belongs to the 'phage' integrase family
G6545_RS12870	COG0583	DNA-binding transcription factor activity
G6545_RS12875	COG0028	Belongs to the TPP enzyme family
G6545_RS12890	COG0028	Belongs to the TPP enzyme family
G6545_RS12895	COG1126	abc transporter atp-binding protein
G6545_RS12900	COG0765	amino acid transport
G6545_RS12915	COG1414	Transcriptional regulator
G6545_RS12920	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G6545_RS12925	COG0009	L-threonylcarbamoyladenylate synthase
G6545_RS12930	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
G6545_RS12935	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
G6545_RS12940	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
G6545_RS12950	COG2944	sequence-specific DNA binding
G6545_RS12960	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
G6545_RS13010	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
G6545_RS13020	COG0739	heme binding
G6545_RS13030	COG0521	Mo-molybdopterin cofactor biosynthetic process
G6545_RS13035	COG0306	phosphate transporter
G6545_RS13045	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
G6545_RS13075	COG0625	glutathione transferase activity
G6545_RS13090	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
G6545_RS13095	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
G6545_RS13105	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
G6545_RS13110	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
G6545_RS13115	COG1385	rRNA (uridine-N3-)-methyltransferase activity
G6545_RS13120	COG2732	(Barnase) inhibitor
G6545_RS13130	COG0281	malic enzyme
G6545_RS13130	COG0280	phosphate acetyltransferase
G6545_RS13140	COG0436	Aminotransferase
G6545_RS13145	COG0741	lytic transglycosylase activity
G6545_RS13150	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
G6545_RS13190	COG2027	D-alanyl-D-alanine carboxypeptidase
G6545_RS13200	COG0343	queuine tRNA-ribosyltransferase activity
G6545_RS13205	COG1862	Preprotein translocase
G6545_RS13210	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
G6545_RS13215	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
G6545_RS13225	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
G6545_RS13230	COG1702	phosphate starvation-inducible protein PhoH
G6545_RS13235	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
G6545_RS13240	COG4535	Mg2 and Co2 transporter CorC
G6545_RS13245	COG0815	Transfers the fatty acyl group on membrane lipoproteins
G6545_RS13250	COG0667	Aldo Keto reductase
G6545_RS13270	COG1802	Transcriptional regulator
G6545_RS13280	COG3181	Tripartite tricarboxylate transporter family receptor
G6545_RS13300	COG0523	cobalamin synthesis protein
G6545_RS13305	COG1335	isochorismatase
G6545_RS13310	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
G6545_RS13315	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
G6545_RS13360	COG0697	spore germination
G6545_RS13370	COG0678	peroxiredoxin activity
G6545_RS13380	COG0412	Dienelactone hydrolase
G6545_RS13395	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
G6545_RS13405	COG0521	Mo-molybdopterin cofactor biosynthetic process
G6545_RS13410	COG0303	'Molybdopterin
G6545_RS13415	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
G6545_RS13435	COG3383	formate dehydrogenase (NAD+) activity
G6545_RS13440	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
G6545_RS13450	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
G6545_RS13470	COG5006	permease, DMT superfamily
G6545_RS13485	COG0477	Major facilitator Superfamily
G6545_RS13490	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
G6545_RS13495	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
G6545_RS13500	COG1845	cytochrome c oxidase, subunit III
G6545_RS13505	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
G6545_RS13515	COG1028	Short-chain dehydrogenase reductase Sdr
G6545_RS13540	COG1666	GTP binding
G6545_RS13555	COG4942	peptidase
G6545_RS13605	COG0640	Transcriptional regulator
G6545_RS13610	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
G6545_RS13615	COG1845	cytochrome c oxidase, subunit III
G6545_RS13620	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
G6545_RS13630	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
G6545_RS13655	COG0583	DNA-binding transcription factor activity
G6545_RS13670	COG0583	DNA-binding transcription factor activity
G6545_RS13700	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
G6545_RS13710	COG2900	Belongs to the SlyX family
G6545_RS13730	COG1917	Cupin 2, conserved barrel domain protein
G6545_RS13730	COG2207	Transcriptional regulator
G6545_RS13745	COG2070	2-Nitropropane dioxygenase
G6545_RS13755	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
G6545_RS13760	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
G6545_RS13800	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
G6545_RS13805	COG0596	Alpha beta hydrolase
G6545_RS13835	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G6545_RS13845	COG1294	oxidase, subunit
G6545_RS13850	COG1271	oxidase subunit
G6545_RS13870	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
G6545_RS13870	COG2169	Transcriptional regulator
G6545_RS13885	COG3945	hemerythrin HHE cation binding domain
G6545_RS13900	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
G6545_RS13915	COG0154	amidase activity
G6545_RS13925	COG0456	acetyltransferase
G6545_RS13940	COG2203	Gaf domain
G6545_RS13940	COG2199	diguanylate cyclase activity
G6545_RS13950	COG1024	Enoyl-CoA hydratase
G6545_RS13960	COG1012	belongs to the aldehyde dehydrogenase family
G6545_RS13985	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
G6545_RS14000	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
G6545_RS14035	COG0583	DNA-binding transcription factor activity
G6545_RS14045	COG1309	transcriptional regulator
G6545_RS14050	COG2076	Multidrug Resistance protein
G6545_RS14055	COG1028	Short-chain dehydrogenase reductase Sdr
G6545_RS14065	COG1960	acyl-CoA dehydrogenase activity
G6545_RS14070	COG1309	transcriptional regulator
G6545_RS14080	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G6545_RS14090	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
G6545_RS14105	COG1538	Outer membrane efflux protein
G6545_RS14115	COG2274	protein secretion by the type I secretion system
G6545_RS14120	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G6545_RS14145	COG1335	isochorismatase
G6545_RS14150	COG1448	Aminotransferase
G6545_RS14155	COG1418	mRNA catabolic process
G6545_RS14175	COG1063	alcohol dehydrogenase
G6545_RS14185	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
G6545_RS14195	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G6545_RS14205	COG0318	PFAM AMP-dependent synthetase and ligase
G6545_RS14215	COG1522	sequence-specific DNA binding
G6545_RS14220	COG3181	Tripartite tricarboxylate transporter family receptor
G6545_RS14225	COG0307	riboflavin synthase, alpha
G6545_RS14230	COG2807	transmembrane transport
G6545_RS14235	COG0590	tRNA wobble adenosine to inosine editing
G6545_RS14245	COG0583	DNA-binding transcription factor activity
G6545_RS14250	COG1902	pentaerythritol trinitrate reductase activity
G6545_RS14270	COG0559	Belongs to the binding-protein-dependent transport system permease family
G6545_RS14275	COG0251	oxidation-reduction process
G6545_RS14280	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
G6545_RS14295	COG1414	Transcriptional regulator
G6545_RS14300	COG1028	Short-chain dehydrogenase reductase Sdr
G6545_RS14315	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G6545_RS14325	COG1024	Enoyl-CoA hydratase
G6545_RS14330	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G6545_RS14335	COG0154	amidase activity
G6545_RS14360	COG2188	Transcriptional regulator
G6545_RS14365	COG3795	YCII-related domain
G6545_RS14400	COG1960	acyl-CoA dehydrogenase activity
G6545_RS14405	COG0318	PFAM AMP-dependent synthetase and ligase
G6545_RS14410	COG1024	Enoyl-CoA hydratase
G6545_RS14415	COG1024	Enoyl-CoA hydratase
G6545_RS14435	COG0583	DNA-binding transcription factor activity
G6545_RS14450	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
G6545_RS14480	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
G6545_RS14490	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
G6545_RS14520	COG4566	intracellular signal transduction
G6545_RS14525	COG4191	Histidine kinase
G6545_RS14530	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
G6545_RS14535	COG3181	Tripartite tricarboxylate transporter family receptor
G6545_RS14540	COG1960	acyl-CoA dehydrogenase activity
G6545_RS14545	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G6545_RS14550	COG0583	DNA-binding transcription factor activity
G6545_RS14570	COG3181	Tripartite tricarboxylate transporter family receptor
G6545_RS14575	COG0583	DNA-binding transcription factor activity
G6545_RS14580	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G6545_RS14585	COG1024	Enoyl-CoA hydratase
G6545_RS14595	COG1024	Enoyl-CoA hydratase
G6545_RS14600	COG0183	Belongs to the thiolase family
G6545_RS14615	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G6545_RS14650	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
G6545_RS14655	COG1802	Transcriptional regulator
G6545_RS14670	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G6545_RS14690	COG3181	Tripartite tricarboxylate transporter family receptor
G6545_RS14725	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
G6545_RS14730	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G6545_RS14745	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
G6545_RS14755	COG0583	DNA-binding transcription factor activity
G6545_RS14775	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
G6545_RS14785	COG3386	PFAM SMP-30 Gluconolaconase
G6545_RS14790	COG3181	Tripartite tricarboxylate transporter family receptor
G6545_RS14805	COG1177	transmembrane transport
G6545_RS14835	COG1024	Enoyl-CoA hydratase
G6545_RS14840	COG0583	DNA-binding transcription factor activity
G6545_RS14850	COG1850	ribulose-bisphosphate carboxylase activity
G6545_RS14870	COG2084	Dehydrogenase
G6545_RS14880	COG1024	Enoyl-CoA hydratase
G6545_RS14890	COG0583	DNA-binding transcription factor activity
G6545_RS14900	COG3119	arylsulfatase activity
G6545_RS14905	COG0583	DNA-binding transcription factor activity
G6545_RS14925	COG0583	DNA-binding transcription factor activity
G6545_RS14935	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G6545_RS14945	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
G6545_RS14950	COG0066	3-isopropylmalate dehydratase activity
G6545_RS14955	COG0473	3-isopropylmalate dehydrogenase activity
G6545_RS14965	COG2423	ornithine cyclodeaminase activity
G6545_RS15000	COG4172	Belongs to the ABC transporter superfamily
G6545_RS15015	COG0318	PFAM AMP-dependent synthetase and ligase
G6545_RS15020	COG1250	3-hydroxyacyl-CoA dehydrogenase
G6545_RS15020	COG1024	Enoyl-CoA hydratase
G6545_RS15045	COG3842	ATPase activity
G6545_RS15070	COG5001	Diguanylate cyclase
G6545_RS15075	COG0583	DNA-binding transcription factor activity
G6545_RS15080	COG3181	Tripartite tricarboxylate transporter family receptor
G6545_RS15105	COG0583	DNA-binding transcription factor activity
G6545_RS15110	COG3181	Tripartite tricarboxylate transporter family receptor
G6545_RS15115	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G6545_RS15120	COG1960	acyl-CoA dehydrogenase activity
G6545_RS15135	COG0405	Gamma-glutamyltransferase
G6545_RS15150	COG1335	isochorismatase
G6545_RS15165	COG1414	Transcriptional regulator
G6545_RS15170	COG3181	Tripartite tricarboxylate transporter family receptor
G6545_RS15180	COG0583	DNA-binding transcription factor activity
G6545_RS15190	COG1053	succinate dehydrogenase
G6545_RS15210	COG2015	COG2015, Alkyl sulfatase and related hydrolases
G6545_RS15220	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
G6545_RS15230	COG3468	outer membrane autotransporter barrel domain protein
G6545_RS15245	COG1252	NADH dehydrogenase
G6545_RS15250	COG0284	orotidine-5'-phosphate decarboxylase activity
G6545_RS15255	COG1546	Belongs to the CinA family
G6545_RS15255	COG1058	Belongs to the CinA family
G6545_RS15260	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
G6545_RS15270	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
G6545_RS15275	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
G6545_RS15300	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
G6545_RS15305	COG3639	organic phosphonate transmembrane transporter activity
G6545_RS15310	COG3639	organic phosphonate transmembrane transporter activity
G6545_RS15325	COG0742	ribosomal rna small subunit methyltransferase
G6545_RS15330	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
G6545_RS15335	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
G6545_RS15340	COG3135	benzoate transporter
G6545_RS15355	COG0640	Transcriptional regulator
G6545_RS15370	COG0583	DNA-binding transcription factor activity
G6545_RS15380	COG0747	negative chemotaxis
G6545_RS15385	COG4172	Belongs to the ABC transporter superfamily
G6545_RS15390	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G6545_RS15395	COG0601	transmembrane transport
G6545_RS15405	COG0281	malic enzyme
G6545_RS15405	COG0280	phosphate acetyltransferase
G6545_RS15430	COG2814	Major facilitator Superfamily
G6545_RS15440	COG1309	transcriptional regulator
G6545_RS15445	COG3181	Tripartite tricarboxylate transporter family receptor
G6545_RS15480	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
G6545_RS15485	COG1111	helicase
G6545_RS15485	COG1205	dead DEAH box helicase
G6545_RS15495	COG0582	viral genome integration into host DNA
G6545_RS15500	COG0012	GTP binding
G6545_RS15530	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
G6545_RS15545	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
G6545_RS15580	COG1368	sulfuric ester hydrolase activity
G6545_RS15585	COG0642	Histidine kinase
G6545_RS15590	COG0745	RESPONSE REGULATOR receiver
G6545_RS15595	COG0277	FAD linked oxidase domain protein
G6545_RS15610	COG0166	Belongs to the GPI family
G6545_RS15615	COG0438	transferase activity, transferring glycosyl groups
G6545_RS15620	COG0438	transferase activity, transferring glycosyl groups
G6545_RS15635	COG0438	transferase activity, transferring glycosyl groups
G6545_RS15650	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
G6545_RS15655	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
G6545_RS15680	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G6545_RS15695	COG0747	negative chemotaxis
G6545_RS15700	COG0601	transmembrane transport
G6545_RS15705	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G6545_RS15710	COG4172	Belongs to the ABC transporter superfamily
G6545_RS15730	COG1024	Enoyl-CoA hydratase
G6545_RS15750	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
G6545_RS15750	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
G6545_RS15755	COG0509	glycine decarboxylation via glycine cleavage system
G6545_RS15760	COG0404	The glycine cleavage system catalyzes the degradation of glycine
G6545_RS15770	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
G6545_RS15775	COG2081	HI0933 family
G6545_RS15780	COG1982	Orn Lys Arg decarboxylase major
G6545_RS15820	COG0489	protein tyrosine kinase activity
G6545_RS15860	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
G6545_RS15870	COG4772	TonB-dependent receptor
G6545_RS15915	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
G6545_RS15920	COG3468	outer membrane autotransporter barrel domain protein
G6545_RS15930	COG0387	Pfam Sodium calcium exchanger
G6545_RS16040	COG5444	nuclease activity
G6545_RS16060	COG3501	Rhs element vgr protein
G6545_RS16115	COG3409	Peptidoglycan-binding domain 1 protein
G6545_RS16115	COG3267	Type II secretory pathway component ExeA
G6545_RS16120	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
G6545_RS16125	COG1459	type II secretion system
G6545_RS16170	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G6545_RS16185	COG3181	Tripartite tricarboxylate transporter family receptor
G6545_RS16195	COG2030	dehydratase
G6545_RS16200	COG0183	Belongs to the thiolase family
G6545_RS16245	COG1960	acyl-CoA dehydrogenase activity
G6545_RS16260	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G6545_RS16265	COG1028	Short-chain dehydrogenase reductase Sdr
G6545_RS16270	COG1024	Enoyl-CoA hydratase
G6545_RS16325	COG3971	2-oxopent-4-enoate hydratase activity
G6545_RS16335	COG3384	dioxygenase
G6545_RS16340	COG1012	belongs to the aldehyde dehydrogenase family
G6545_RS16360	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
G6545_RS16375	COG1028	Short-chain dehydrogenase reductase Sdr
G6545_RS16380	COG4638	Rieske (2fe-2S)
G6545_RS16385	COG0633	Ferredoxin
G6545_RS16385	COG0543	2 iron, 2 sulfur cluster binding
G6545_RS16390	COG3181	Tripartite tricarboxylate transporter family receptor
G6545_RS16425	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
G6545_RS16440	COG1335	isochorismatase
G6545_RS16445	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G6545_RS16450	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
G6545_RS16475	COG3135	benzoate transporter
G6545_RS16490	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
G6545_RS16550	COG0154	amidase activity
G6545_RS16560	COG1414	Transcriptional regulator
G6545_RS16565	COG1473	amidohydrolase
G6545_RS16585	COG0436	Aminotransferase
G6545_RS16590	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
G6545_RS16630	COG0626	cystathionine gamma-synthase activity
G6545_RS16635	COG1012	belongs to the aldehyde dehydrogenase family
G6545_RS16640	COG2186	Transcriptional regulator
G6545_RS16650	COG3181	Tripartite tricarboxylate transporter family receptor
G6545_RS16655	COG0625	glutathione transferase activity
G6545_RS16670	COG2267	carboxylic ester hydrolase activity
G6545_RS16675	COG0583	DNA-binding transcription factor activity
G6545_RS16690	COG3181	Tripartite tricarboxylate transporter family receptor
G6545_RS16695	COG0183	Belongs to the thiolase family
G6545_RS16700	COG1024	Enoyl-CoA hydratase
G6545_RS16705	COG1960	acyl-CoA dehydrogenase activity
G6545_RS16715	COG1024	Enoyl-CoA hydratase
G6545_RS16740	COG1960	acyl-CoA dehydrogenase activity
G6545_RS16765	COG3181	Tripartite tricarboxylate transporter family receptor
G6545_RS16775	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
G6545_RS16785	COG1012	belongs to the aldehyde dehydrogenase family
G6545_RS16790	COG3181	Tripartite tricarboxylate transporter family receptor
G6545_RS16795	COG1028	Short-chain dehydrogenase reductase Sdr
G6545_RS16800	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
G6545_RS16805	COG1414	Transcriptional regulator
G6545_RS16820	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
G6545_RS16825	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G6545_RS16830	COG0431	NADPH-dependent FMN reductase
G6545_RS16855	COG1024	Enoyl-CoA hydratase
G6545_RS16860	COG1454	alcohol dehydrogenase
G6545_RS16865	COG3181	Tripartite tricarboxylate transporter family receptor
G6545_RS16870	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G6545_RS16875	COG1024	Enoyl-CoA hydratase
G6545_RS16895	COG1024	Enoyl-CoA hydratase
G6545_RS16905	COG1309	transcriptional regulator
G6545_RS16930	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
G6545_RS16945	COG1960	acyl-CoA dehydrogenase activity
G6545_RS16950	COG0583	DNA-binding transcription factor activity
G6545_RS16955	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G6545_RS16965	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
G6545_RS16970	COG0183	Belongs to the thiolase family
G6545_RS16985	COG1960	acyl-CoA dehydrogenase activity
G6545_RS16990	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
G6545_RS17005	COG0318	PFAM AMP-dependent synthetase and ligase
G6545_RS17010	COG0427	acetyl-CoA hydrolase
G6545_RS17025	COG1902	pentaerythritol trinitrate reductase activity
G6545_RS17025	COG0446	pyridine nucleotide-disulphide oxidoreductase
G6545_RS17045	COG0559	Belongs to the binding-protein-dependent transport system permease family
G6545_RS17070	COG3181	Tripartite tricarboxylate transporter family receptor
G6545_RS17075	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G6545_RS17080	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G6545_RS17090	COG2030	dehydratase
G6545_RS17105	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
G6545_RS17115	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
G6545_RS17125	COG0318	PFAM AMP-dependent synthetase and ligase
G6545_RS17130	COG1028	Short-chain dehydrogenase reductase Sdr
G6545_RS17135	COG1960	acyl-CoA dehydrogenase activity
G6545_RS17140	COG1028	Short-chain dehydrogenase reductase Sdr
G6545_RS17160	COG1309	transcriptional regulator
G6545_RS17170	COG0683	leucine binding
G6545_RS17205	COG3976	FMN-binding domain protein
G6545_RS17205	COG1053	succinate dehydrogenase
G6545_RS17215	COG1609	Transcriptional regulator
G6545_RS17220	COG0318	PFAM AMP-dependent synthetase and ligase
G6545_RS17240	COG1414	Transcriptional regulator
G6545_RS17245	COG3181	Tripartite tricarboxylate transporter family receptor
G6545_RS17250	COG1024	Enoyl-CoA hydratase
G6545_RS17250	COG1250	3-hydroxyacyl-CoA dehydrogenase
G6545_RS17255	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G6545_RS17260	COG0028	Belongs to the TPP enzyme family
G6545_RS17285	COG3181	Tripartite tricarboxylate transporter family receptor
G6545_RS17290	COG1024	Enoyl-CoA hydratase
G6545_RS17300	COG3181	Tripartite tricarboxylate transporter family receptor
G6545_RS17305	COG0583	DNA-binding transcription factor activity
G6545_RS17360	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
G6545_RS17395	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
G6545_RS17400	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G6545_RS17425	COG1652	LysM domain
G6545_RS17430	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
G6545_RS17435	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
G6545_RS17450	COG0625	glutathione transferase activity
G6545_RS17455	COG0326	Molecular chaperone. Has ATPase activity
G6545_RS17515	COG1819	glycosyl
G6545_RS17520	COG0523	cobalamin synthesis protein
G6545_RS17525	COG1228	amidohydrolase
G6545_RS17540	COG3119	arylsulfatase activity
G6545_RS17550	COG0583	DNA-binding transcription factor activity
G6545_RS17555	COG1278	Cold shock
G6545_RS17585	COG2031	fatty acid transporter
G6545_RS17590	COG1017	nitric oxide dioxygenase activity
G6545_RS17590	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
G6545_RS17595	COG0251	oxidation-reduction process
G6545_RS17620	COG0583	DNA-binding transcription factor activity
G6545_RS17625	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G6545_RS17630	COG0604	alcohol dehydrogenase
G6545_RS17640	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
G6545_RS17645	COG1024	Enoyl-CoA hydratase
G6545_RS17650	COG1414	Transcriptional regulator
G6545_RS17655	COG0318	PFAM AMP-dependent synthetase and ligase
G6545_RS17660	COG3181	Tripartite tricarboxylate transporter family receptor
G6545_RS17690	COG0583	DNA-binding transcription factor activity
G6545_RS17705	COG3422	double-strand break repair
G6545_RS17710	COG0330	HflC and HflK could
G6545_RS17720	COG0251	oxidation-reduction process
G6545_RS17725	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
G6545_RS17735	COG0628	permease
G6545_RS17740	COG0583	DNA-binding transcription factor activity
G6545_RS17755	COG1538	Outer membrane efflux protein
G6545_RS17765	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
G6545_RS17770	COG4569	acetaldehyde dehydrogenase (acetylating) activity
G6545_RS17780	COG2207	Transcriptional regulator
G6545_RS17785	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
G6545_RS17795	COG0657	acetylesterase activity
G6545_RS17800	COG0747	negative chemotaxis
G6545_RS17805	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
G6545_RS17810	COG2808	Putative FMN-binding domain
G6545_RS17815	COG4257	antibiotic catabolic process
G6545_RS17825	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
G6545_RS17830	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
G6545_RS17840	COG1250	3-hydroxyacyl-CoA dehydrogenase
G6545_RS17845	COG2031	fatty acid transporter
G6545_RS17850	COG1028	Short-chain dehydrogenase reductase Sdr
G6545_RS17855	COG1414	Transcriptional regulator
G6545_RS17865	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
G6545_RS17880	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
G6545_RS17900	COG0288	reversible hydration of carbon dioxide
G6545_RS17905	COG0154	amidase activity
G6545_RS17910	COG0683	leucine binding
G6545_RS17915	COG0583	DNA-binding transcription factor activity
G6545_RS17920	COG4211	Belongs to the binding-protein-dependent transport system permease family
G6545_RS17955	COG1464	Belongs to the NlpA lipoprotein family
G6545_RS17990	COG3181	Tripartite tricarboxylate transporter family receptor
G6545_RS18000	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
G6545_RS18005	COG2890	protein-(glutamine-N5) methyltransferase activity
G6545_RS18010	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
G6545_RS18045	COG0745	RESPONSE REGULATOR receiver
G6545_RS18070	COG1902	pentaerythritol trinitrate reductase activity
G6545_RS18085	COG1028	Short-chain dehydrogenase reductase Sdr
G6545_RS18120	COG1024	Enoyl-CoA hydratase
G6545_RS18125	COG0583	DNA-binding transcription factor activity
G6545_RS18150	COG0583	DNA-binding transcription factor activity
G6545_RS18185	COG2188	Transcriptional regulator
G6545_RS18190	COG2301	Belongs to the HpcH HpaI aldolase family
G6545_RS18195	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G6545_RS18200	COG0583	DNA-binding transcription factor activity
G6545_RS18210	COG0028	Belongs to the TPP enzyme family
G6545_RS18230	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G6545_RS18240	COG0318	PFAM AMP-dependent synthetase and ligase
G6545_RS18250	COG1802	Transcriptional regulator
G6545_RS18265	COG1802	Transcriptional regulator
G6545_RS18275	COG1028	Short-chain dehydrogenase reductase Sdr
G6545_RS18295	COG1126	abc transporter atp-binding protein
G6545_RS18300	COG0765	amino acid transport
G6545_RS18305	COG0765	amino acid transport
G6545_RS18320	COG1538	Outer membrane efflux protein
G6545_RS18325	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G6545_RS18330	COG2274	protein secretion by the type I secretion system
G6545_RS18335	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
G6545_RS18345	COG2994	toxin metabolic process
G6545_RS18360	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G6545_RS18365	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
G6545_RS18375	COG0583	DNA-binding transcription factor activity
G6545_RS18385	COG0142	geranyltranstransferase activity
G6545_RS18395	COG0261	This protein binds to 23S rRNA in the presence of protein L20
G6545_RS18400	COG0211	Belongs to the bacterial ribosomal protein bL27 family
G6545_RS18405	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
G6545_RS18410	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
G6545_RS18440	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
G6545_RS18460	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
G6545_RS18465	COG0793	Belongs to the peptidase S41A family
G6545_RS18470	COG4942	peptidase
G6545_RS18475	COG0588	phosphoglycerate mutase activity
G6545_RS18485	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
G6545_RS18490	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
G6545_RS18495	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
G6545_RS18500	COG3181	Tripartite tricarboxylate transporter family receptor
G6545_RS18515	COG2226	methyltransferase
G6545_RS18535	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G6545_RS18540	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
G6545_RS18565	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
G6545_RS18590	COG1335	isochorismatase
G6545_RS18595	COG2309	aminopeptidase activity
G6545_RS18600	COG0596	Alpha beta hydrolase
G6545_RS18605	COG3473	Maleate cis-trans isomerase
G6545_RS18615	COG2068	MobA-Related Protein
G6545_RS18640	COG2204	response regulator
G6545_RS18645	COG5000	phosphorelay sensor kinase activity
G6545_RS18655	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
G6545_RS18655	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
G6545_RS18665	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
G6545_RS18685	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G6545_RS18690	COG1942	4-Oxalocrotonate Tautomerase
G6545_RS18695	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
G6545_RS18715	COG0546	phosphoglycolate phosphatase activity
G6545_RS18725	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
G6545_RS18730	COG0242	peptide deformylase activity
G6545_RS18740	COG1522	sequence-specific DNA binding
G6545_RS18745	COG0758	DNA mediated transformation
G6545_RS18760	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G6545_RS18765	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G6545_RS18770	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
G6545_RS18785	COG0583	DNA-binding transcription factor activity
G6545_RS18845	COG0640	Transcriptional regulator
G6545_RS18870	COG0438	transferase activity, transferring glycosyl groups
G6545_RS18890	COG0735	belongs to the Fur family
G6545_RS18905	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
G6545_RS18910	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
G6545_RS18920	COG0513	Belongs to the DEAD box helicase family
G6545_RS18930	COG0617	tRNA 3'-terminal CCA addition
G6545_RS18945	COG0477	Major facilitator Superfamily
G6545_RS18955	COG0583	DNA-binding transcription factor activity
G6545_RS18965	COG1950	PFAM Membrane protein of
G6545_RS18985	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
G6545_RS18995	COG1560	Kdo2-lipid A biosynthetic process
G6545_RS19000	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
G6545_RS19010	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
G6545_RS19020	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
G6545_RS19030	COG0803	Belongs to the bacterial solute-binding protein 9 family
G6545_RS19040	COG1121	(ABC) transporter
G6545_RS19050	COG0735	belongs to the Fur family
G6545_RS19055	COG0523	cobalamin synthesis protein
G6545_RS19070	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
G6545_RS19080	COG2096	Adenosyltransferase
G6545_RS19100	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
G6545_RS19105	COG0321	lipoyl(octanoyl) transferase activity
G6545_RS19120	COG1686	Belongs to the peptidase S11 family
G6545_RS19140	COG1127	ABC transporter
G6545_RS19145	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
G6545_RS19155	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
G6545_RS19170	COG0859	PFAM glycosyl transferase family 9
G6545_RS19200	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
G6545_RS19205	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
G6545_RS19210	COG0438	transferase activity, transferring glycosyl groups
G6545_RS19230	COG0438	transferase activity, transferring glycosyl groups
G6545_RS19240	COG0367	asparagine synthase
G6545_RS19265	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
G6545_RS19270	COG0367	asparagine synthase
G6545_RS19305	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
G6545_RS19315	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
G6545_RS19335	COG0367	asparagine synthase
G6545_RS19345	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
G6545_RS19355	COG0477	Major facilitator Superfamily
G6545_RS19365	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
G6545_RS19370	COG3568	Endonuclease Exonuclease Phosphatase
G6545_RS19375	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
G6545_RS19410	COG0531	amino acid
G6545_RS19440	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
G6545_RS19445	COG1956	GAF domain-containing protein
G6545_RS19450	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G6545_RS19470	COG2186	Transcriptional regulator
G6545_RS19495	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G6545_RS19515	COG0438	transferase activity, transferring glycosyl groups
G6545_RS19525	COG0402	S-adenosylhomocysteine deaminase activity
G6545_RS19560	COG0629	single-stranded DNA binding
G6545_RS19565	COG2814	Major facilitator Superfamily
G6545_RS19580	COG0232	Belongs to the dGTPase family. Type 2 subfamily
G6545_RS19585	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
G6545_RS19590	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
G6545_RS19615	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
G6545_RS19620	COG1333	cytochrome c biogenesis protein
G6545_RS19630	COG0218	Necessary for normal cell division and for the maintenance of normal septation
G6545_RS19645	COG4232	protein-disulfide reductase activity
G6545_RS19650	COG1324	tolerance protein
G6545_RS19655	COG0537	adenosine 5'-monophosphoramidase activity
G6545_RS19660	COG0203	ribosomal protein L17
G6545_RS19665	COG0202	RNA polymerase activity
G6545_RS19670	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
G6545_RS19675	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
G6545_RS19680	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
G6545_RS19685	COG0257	Belongs to the bacterial ribosomal protein bL36 family
G6545_RS19690	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
G6545_RS19695	COG0201	protein transport
G6545_RS19700	COG0200	Binds to the 23S rRNA
G6545_RS19705	COG1841	ribosomal large subunit assembly
G6545_RS19710	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
G6545_RS19715	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
G6545_RS19725	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
G6545_RS19730	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
G6545_RS19735	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
G6545_RS19740	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
G6545_RS19745	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
G6545_RS19765	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
G6545_RS19770	COG0255	Belongs to the universal ribosomal protein uL29 family
G6545_RS19775	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
G6545_RS19780	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
G6545_RS19785	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
G6545_RS19795	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
G6545_RS19800	COG0089	rRNA binding
G6545_RS19810	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
G6545_RS19815	COG0051	transcription antitermination factor activity, RNA binding
G6545_RS19820	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
G6545_RS19825	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
G6545_RS19830	COG0049	tRNA binding
G6545_RS19835	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
G6545_RS19845	COG1230	cation diffusion facilitator family transporter
G6545_RS19880	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
G6545_RS19885	COG0085	RNA polymerase activity
G6545_RS19890	COG0222	ribosome binding
G6545_RS19895	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
G6545_RS19900	COG0081	regulation of translation
G6545_RS19915	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
G6545_RS19925	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
G6545_RS19945	COG0252	asparaginase activity
G6545_RS19950	COG1475	DNA binding
G6545_RS19960	COG1192	Involved in chromosome partitioning
G6545_RS19965	COG0357	Ribosomal RNA small subunit methyltransferase G
G6545_RS19975	COG1278	Cold shock
G6545_RS19980	COG0436	Aminotransferase
G6545_RS20000	COG3850	Histidine kinase
G6545_RS20000	COG5002	protein histidine kinase activity
G6545_RS20020	COG0747	negative chemotaxis
G6545_RS20025	COG0601	transmembrane transport
G6545_RS20035	COG0444	Belongs to the ABC transporter superfamily
G6545_RS20040	COG4608	Belongs to the ABC transporter superfamily
G6545_RS20045	COG1473	amidohydrolase
G6545_RS20050	COG2175	clavaminate synthase activity
G6545_RS20060	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
G6545_RS20065	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G6545_RS20070	COG0753	catalase activity
G6545_RS20075	COG0706	membrane insertase activity
G6545_RS20080	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
G6545_RS20085	COG0594	ribonuclease P activity
G6545_RS20090	COG0230	Belongs to the bacterial ribosomal protein bL34 family
G6545_RS20120	COG1414	Transcriptional regulator
G6545_RS20125	COG0154	amidase activity
G6545_RS20140	COG1304	FMN binding
G6545_RS20165	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
G6545_RS20195	COG3781	membrane
G6545_RS20200	COG1522	sequence-specific DNA binding
G6545_RS20205	COG0028	Belongs to the TPP enzyme family
G6545_RS20215	COG1012	belongs to the aldehyde dehydrogenase family
G6545_RS20220	COG1028	Short-chain dehydrogenase reductase Sdr
G6545_RS20225	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G6545_RS20230	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
G6545_RS20250	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
G6545_RS20255	COG2922	Belongs to the Smg family
G6545_RS20260	COG1629	transport
G6545_RS20270	COG2358	TRAP transporter, solute receptor (TAXI family
G6545_RS20280	COG3181	Tripartite tricarboxylate transporter family receptor
G6545_RS20285	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
G6545_RS20300	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
G6545_RS20305	COG0183	Belongs to the thiolase family
G6545_RS20310	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
G6545_RS20315	COG1960	acyl-CoA dehydrogenase activity
G6545_RS20330	COG1280	lysine exporter protein (LysE YggA)
G6545_RS20350	COG0018	arginyl-trna synthetase
G6545_RS20365	COG0395	ABC-type sugar transport system, permease component
G6545_RS20370	COG1175	transmembrane transport
G6545_RS20375	COG1653	transport
G6545_RS20380	COG3842	ATPase activity
G6545_RS20385	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
G6545_RS20390	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
G6545_RS20410	COG1609	Transcriptional regulator
G6545_RS20415	COG0154	amidase activity
G6545_RS20420	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
G6545_RS20430	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
G6545_RS20440	COG0583	DNA-binding transcription factor activity
G6545_RS20460	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
G6545_RS20465	COG1280	lysine exporter protein (LysE YggA)
G6545_RS20470	COG0513	Belongs to the DEAD box helicase family
G6545_RS20480	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
G6545_RS20490	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G6545_RS20500	COG0747	negative chemotaxis
G6545_RS20505	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
G6545_RS20525	COG0697	spore germination
G6545_RS20535	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
G6545_RS20540	COG2948	multi-organism process
G6545_RS20550	COG3736	Type IV secretory pathway, component VirB8
G6545_RS20565	COG3451	type IV secretory pathway VirB4
G6545_RS20570	COG3702	type iv secretory pathway
G6545_RS20605	COG3181	Tripartite tricarboxylate transporter family receptor
G6545_RS20625	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G6545_RS20635	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G6545_RS20655	COG0492	ferredoxin-NADP+ reductase activity
G6545_RS20660	COG0583	DNA-binding transcription factor activity
G6545_RS20690	COG2969	positive regulation of protein catabolic process
G6545_RS20695	COG0625	glutathione transferase activity
G6545_RS20700	COG2857	Cytochrome c1
G6545_RS20705	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
G6545_RS20710	COG0723	plastoquinol--plastocyanin reductase activity
G6545_RS20715	COG1970	mechanosensitive ion channel activity
G6545_RS20720	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
G6545_RS20740	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
G6545_RS20745	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
G6545_RS20750	COG0537	adenosine 5'-monophosphoramidase activity
G6545_RS20755	COG0140	phosphoribosyl-ATP diphosphatase activity
G6545_RS20765	COG0107	imidazoleglycerol-phosphate synthase activity
G6545_RS20770	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
G6545_RS20775	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
G6545_RS20780	COG0131	Imidazoleglycerol-phosphate dehydratase
G6545_RS20785	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
G6545_RS20790	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
G6545_RS20800	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
G6545_RS20810	COG0842	Transport permease protein
G6545_RS20815	COG1131	(ABC) transporter
G6545_RS20825	COG2853	Lipoprotein
G6545_RS20830	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
G6545_RS20835	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
G6545_RS20840	COG1127	ABC transporter
G6545_RS20850	COG3047	cAMP biosynthetic process
G6545_RS20860	COG0070	glutamate synthase
G6545_RS20860	COG0069	glutamate synthase activity
G6545_RS20860	COG0067	glutamate synthase
G6545_RS20870	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
G6545_RS20875	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
G6545_RS20885	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
G6545_RS20890	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
G6545_RS20910	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
G6545_RS20950	COG1999	signal sequence binding
G6545_RS20975	COG2814	Major facilitator Superfamily
G6545_RS20990	COG2207	Transcriptional regulator
G6545_RS20990	COG3708	Transcriptional regulator
G6545_RS21000	COG1522	sequence-specific DNA binding
G6545_RS21015	COG3181	Tripartite tricarboxylate transporter family receptor
G6545_RS21025	COG1024	Enoyl-CoA hydratase
G6545_RS21040	COG0604	alcohol dehydrogenase
G6545_RS21045	COG2072	flavoprotein involved in K transport
G6545_RS21060	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
G6545_RS21070	COG1960	acyl-CoA dehydrogenase activity
G6545_RS21075	COG1960	acyl-CoA dehydrogenase activity
G6545_RS21080	COG0277	FAD linked oxidase domain protein
G6545_RS21090	COG3181	Tripartite tricarboxylate transporter family receptor
G6545_RS21105	COG0583	DNA-binding transcription factor activity
G6545_RS21110	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
G6545_RS21120	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
G6545_RS21130	COG3842	ATPase activity
G6545_RS21170	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G6545_RS21175	COG2030	dehydratase
G6545_RS21180	COG0183	Belongs to the thiolase family
G6545_RS21185	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G6545_RS21190	COG1028	Short-chain dehydrogenase reductase Sdr
G6545_RS21205	COG4771	TonB-dependent receptor
G6545_RS21220	COG1846	Transcriptional regulator
G6545_RS21225	COG1024	Enoyl-CoA hydratase
G6545_RS21230	COG1902	pentaerythritol trinitrate reductase activity
G6545_RS21230	COG0446	pyridine nucleotide-disulphide oxidoreductase
G6545_RS21235	COG1024	Enoyl-CoA hydratase
G6545_RS21240	COG3181	Tripartite tricarboxylate transporter family receptor
G6545_RS21245	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G6545_RS21250	COG1960	acyl-CoA dehydrogenase activity
G6545_RS21260	COG1028	Short-chain dehydrogenase reductase Sdr
G6545_RS21270	COG0604	alcohol dehydrogenase
G6545_RS21280	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G6545_RS21315	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
G6545_RS21320	COG0709	Synthesizes selenophosphate from selenide and ATP
G6545_RS21335	COG0439	Biotin carboxylase
G6545_RS21340	COG0511	ligase activity, forming carbon-carbon bonds
G6545_RS21370	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G6545_RS21375	COG0601	transmembrane transport
G6545_RS21380	COG0747	negative chemotaxis
G6545_RS21385	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
G6545_RS21390	COG1984	allophanate hydrolase subunit 2
G6545_RS21395	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
G6545_RS21410	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
G6545_RS21420	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G6545_RS21425	COG3181	Tripartite tricarboxylate transporter family receptor
G6545_RS21430	COG1960	acyl-CoA dehydrogenase activity
G6545_RS21450	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
G6545_RS21455	COG1024	Enoyl-CoA hydratase
G6545_RS21460	COG1960	acyl-CoA dehydrogenase activity
G6545_RS21485	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
G6545_RS21490	COG0022	dehydrogenase e1 component
G6545_RS21495	COG1024	Enoyl-CoA hydratase
G6545_RS21500	COG0508	dehydrogenase complex catalyzes the overall conversion of
G6545_RS21525	COG0559	Belongs to the binding-protein-dependent transport system permease family
G6545_RS21530	COG0411	ABC transporter
G6545_RS21540	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
G6545_RS21555	COG3181	Tripartite tricarboxylate transporter family receptor
G6545_RS21580	COG4948	Mandelate Racemase Muconate Lactonizing
G6545_RS21590	COG2186	Transcriptional regulator
G6545_RS21605	COG3181	Tripartite tricarboxylate transporter family receptor
G6545_RS21625	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G6545_RS21640	COG3181	Tripartite tricarboxylate transporter family receptor
G6545_RS21645	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
G6545_RS21655	COG1802	Transcriptional regulator
G6545_RS21660	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
G6545_RS21670	COG1234	tRNA 3'-trailer cleavage
G6545_RS21680	COG0583	DNA-binding transcription factor activity
G6545_RS21685	COG3064	Membrane
G6545_RS21715	COG1683	Conserved Protein
G6545_RS21720	COG1120	ATPase activity
G6545_RS21725	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G6545_RS21730	COG4558	Periplasmic binding protein
G6545_RS21735	COG3720	iron ion transport
G6545_RS21745	COG3712	iron ion homeostasis
G6545_RS21750	COG1595	DNA-templated transcription, initiation
G6545_RS21780	COG1802	Transcriptional regulator
G6545_RS21790	COG3069	C4-dicarboxylate transmembrane transporter activity
G6545_RS21835	COG1607	acyl-coa hydrolase
G6545_RS21845	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G6545_RS21865	COG1028	Short-chain dehydrogenase reductase Sdr
G6545_RS21885	COG0512	Glutamine amidotransferase of anthranilate synthase
G6545_RS21895	COG0546	phosphoglycolate phosphatase activity
G6545_RS21900	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
G6545_RS21905	COG2967	ApaG domain
G6545_RS21910	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
G6545_RS21915	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
G6545_RS21925	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
G6545_RS21930	COG0037	tRNA processing
G6545_RS21950	COG1024	Enoyl-CoA hydratase
G6545_RS21965	COG0356	it plays a direct role in the translocation of protons across the membrane
G6545_RS21980	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
G6545_RS21990	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
G6545_RS22000	COG0355	proton-transporting ATP synthase activity, rotational mechanism
G6545_RS22010	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
G6545_RS22015	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
G6545_RS22020	COG0210	DNA helicase
G6545_RS22025	COG2195	Cleaves the N-terminal amino acid of tripeptides
G6545_RS22035	COG4608	Belongs to the ABC transporter superfamily
G6545_RS22040	COG0444	Belongs to the ABC transporter superfamily
G6545_RS22045	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G6545_RS22050	COG0601	transmembrane transport
G6545_RS22060	COG0747	negative chemotaxis
G6545_RS22070	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
G6545_RS22080	COG1024	Enoyl-CoA hydratase
G6545_RS22100	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G6545_RS22105	COG1250	3-hydroxyacyl-CoA dehydrogenase
G6545_RS22125	COG2132	Multicopper oxidase
G6545_RS22145	COG1414	Transcriptional regulator
G6545_RS22155	COG0154	amidase activity
G6545_RS22190	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
G6545_RS22195	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
G6545_RS22200	COG0583	DNA-binding transcription factor activity
G6545_RS22220	COG2918	glutathione biosynthetic process
G6545_RS22245	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
G6545_RS22250	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
G6545_RS22255	COG2813	Specifically methylates the guanine in position
G6545_RS22255	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
G6545_RS22260	COG2223	nitrite transmembrane transporter activity
G6545_RS22265	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
G6545_RS22270	COG1794	racemase activity, acting on amino acids and derivatives
G6545_RS22275	COG1126	abc transporter atp-binding protein
G6545_RS22280	COG0765	amino acid transport
G6545_RS22285	COG0765	amino acid transport
G6545_RS22290	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G6545_RS22295	COG2515	1-aminocyclopropane-1-carboxylate deaminase
G6545_RS22300	COG0583	DNA-binding transcription factor activity
G6545_RS22320	COG3391	amine dehydrogenase activity
G6545_RS22325	COG0473	3-isopropylmalate dehydrogenase activity
G6545_RS22330	COG0583	DNA-binding transcription factor activity
G6545_RS22340	COG2860	membrane
G6545_RS22345	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
G6545_RS22350	COG0708	Exodeoxyribonuclease III
G6545_RS22355	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
G6545_RS22360	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
G6545_RS22370	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
G6545_RS22375	COG1077	Cell shape determining protein MreB Mrl
G6545_RS22380	COG1792	Involved in formation and maintenance of cell shape
G6545_RS22390	COG0768	penicillin binding
G6545_RS22395	COG0772	Belongs to the SEDS family
G6545_RS22400	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
G6545_RS22405	COG0471	metal ion transport
G6545_RS22410	COG1309	transcriptional regulator
G6545_RS22420	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
G6545_RS22435	COG2823	Periplasmic or secreted lipoprotein
G6545_RS22440	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
G6545_RS22455	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
G6545_RS22465	COG1660	Displays ATPase and GTPase activities
G6545_RS22475	COG2010	Cytochrome c
G6545_RS22475	COG1529	Aldehyde oxidase and xanthine dehydrogenase
G6545_RS22490	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
G6545_RS22495	COG1137	ATPase activity
G6545_RS22510	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
G6545_RS22520	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
G6545_RS22535	COG1294	oxidase, subunit
G6545_RS22545	COG4988	ABC transporter
G6545_RS22550	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
G6545_RS22570	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
G6545_RS22575	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
G6545_RS22580	COG1238	metal cluster binding
G6545_RS22590	COG1802	Transcriptional regulator
G6545_RS22600	COG0657	acetylesterase activity
G6545_RS22605	COG1024	Enoyl-CoA hydratase
G6545_RS22615	COG3181	Tripartite tricarboxylate transporter family receptor
G6545_RS22630	COG1984	allophanate hydrolase subunit 2
G6545_RS22635	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
G6545_RS22645	COG0583	DNA-binding transcription factor activity
G6545_RS22650	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
G6545_RS22660	COG5002	protein histidine kinase activity
G6545_RS22670	COG5002	protein histidine kinase activity
G6545_RS22675	COG0745	RESPONSE REGULATOR receiver
G6545_RS22680	COG2226	methyltransferase
G6545_RS22695	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
G6545_RS22705	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
G6545_RS22715	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
G6545_RS22720	COG0351	phosphomethylpyrimidine kinase
G6545_RS22725	COG2022	thiamine diphosphate biosynthetic process
G6545_RS22730	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
G6545_RS22735	COG4206	TonB-dependent receptor
G6545_RS22745	COG2226	methyltransferase
G6545_RS22755	COG1194	a g-specific adenine glycosylase
G6545_RS22765	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
G6545_RS22770	COG2177	Part of the ABC transporter FtsEX involved in
G6545_RS22775	COG2884	Cell division ATP-binding protein ftsE
G6545_RS22780	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G6545_RS22785	COG4597	amino acid ABC transporter
G6545_RS22790	COG0765	amino acid transport
G6545_RS22795	COG1126	abc transporter atp-binding protein
G6545_RS22815	COG0477	Major facilitator Superfamily
G6545_RS22825	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
G6545_RS22830	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
G6545_RS22845	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
G6545_RS22855	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
G6545_RS22880	COG0494	nUDIX hydrolase
G6545_RS22940	COG1028	Short-chain dehydrogenase reductase Sdr
G6545_RS22945	COG1024	Enoyl-CoA hydratase
G6545_RS22950	COG1960	acyl-CoA dehydrogenase activity
G6545_RS22975	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
G6545_RS22980	COG0352	thiamine-phosphate diphosphorylase activity
G6545_RS22995	COG1678	Uncharacterized ACR, COG1678
G6545_RS23005	COG0540	Belongs to the ATCase OTCase family
G6545_RS23030	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
G6545_RS23035	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
G6545_RS23045	COG0557	exoribonuclease II activity
G6545_RS23050	COG3150	esterase
G6545_RS23055	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
G6545_RS23060	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G6545_RS23065	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
G6545_RS23070	COG0511	ligase activity, forming carbon-carbon bonds
G6545_RS23075	COG0439	Biotin carboxylase
G6545_RS23080	COG2264	protein methyltransferase activity
G6545_RS23090	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G6545_RS23110	COG1696	Membrane protein involved in D-alanine export
G6545_RS23115	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
G6545_RS23145	COG1522	sequence-specific DNA binding
G6545_RS23160	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
G6545_RS23165	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
G6545_RS23165	COG1042	CoA-binding domain protein
G6545_RS23165	COG0045	succinate-CoA ligase (ADP-forming) activity
G6545_RS23170	COG1802	Transcriptional regulator
G6545_RS23175	COG3069	C4-dicarboxylate transmembrane transporter activity
G6545_RS23180	COG0513	Belongs to the DEAD box helicase family
G6545_RS23185	COG0346	lactoylglutathione lyase activity
G6545_RS23190	COG1335	isochorismatase
G6545_RS23195	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G6545_RS23200	COG1116	anion transmembrane transporter activity
G6545_RS23220	COG0312	modulator of DNA gyrase
G6545_RS23225	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
G6545_RS23230	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
G6545_RS23235	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
G6545_RS23250	COG0316	Belongs to the HesB IscA family
G6545_RS23265	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
G6545_RS23275	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
G6545_RS23280	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
G6545_RS23285	COG4977	sequence-specific DNA binding
G6545_RS23295	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
G6545_RS23295	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
G6545_RS23300	COG2766	serine protein kinase
G6545_RS23305	COG2718	Belongs to the UPF0229 family
G6545_RS23310	COG2719	SpoVR family
G6545_RS23335	COG2188	Transcriptional regulator
G6545_RS23350	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G6545_RS23375	COG3181	Tripartite tricarboxylate transporter family receptor
G6545_RS23380	COG0583	DNA-binding transcription factor activity
G6545_RS23385	COG0829	nickel cation binding
G6545_RS23390	COG0831	urea catabolic process
G6545_RS23400	COG0832	Belongs to the urease beta subunit family
G6545_RS23405	COG0804	urea catabolic process
G6545_RS23420	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
G6545_RS23445	COG3119	arylsulfatase activity
G6545_RS23460	COG3181	Tripartite tricarboxylate transporter family receptor
G6545_RS23475	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G6545_RS23490	COG1024	Enoyl-CoA hydratase
G6545_RS23505	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G6545_RS23510	COG1309	transcriptional regulator
G6545_RS23515	COG2816	NAD+ diphosphatase activity
G6545_RS23595	COG2979	Protein of unknown function (DUF533)
G6545_RS23610	COG0741	lytic transglycosylase activity
G6545_RS23610	COG1388	LysM domain
G6545_RS23615	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G6545_RS23620	COG2226	methyltransferase
G6545_RS23625	COG0328	RNA-DNA hybrid ribonuclease activity
G6545_RS23630	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G6545_RS23640	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
G6545_RS23655	COG2031	fatty acid transporter
G6545_RS23665	COG0786	glutamate:sodium symporter activity
G6545_RS23675	COG0463	Glycosyl transferase, family 2
G6545_RS23680	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
G6545_RS23710	COG0697	spore germination
G6545_RS23715	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G6545_RS23730	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
G6545_RS23735	COG1285	pathogenesis
G6545_RS23740	COG1253	flavin adenine dinucleotide binding
G6545_RS23745	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G6545_RS23750	COG1024	Enoyl-CoA hydratase
G6545_RS23755	COG3181	Tripartite tricarboxylate transporter family receptor
G6545_RS23760	COG0583	DNA-binding transcription factor activity
G6545_RS23765	COG1960	acyl-CoA dehydrogenase activity
G6545_RS23775	COG0183	Belongs to the thiolase family
G6545_RS23800	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G6545_RS23815	COG3181	Tripartite tricarboxylate transporter family receptor
G6545_RS23820	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
G6545_RS23825	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G6545_RS23840	COG0823	Involved in the tonB-independent uptake of proteins
G6545_RS23850	COG0848	biopolymer transport protein
G6545_RS23855	COG0811	peptide transport
G6545_RS23860	COG0824	Thioesterase
G6545_RS23865	COG0442	prolyl-tRNA aminoacylation
G6545_RS23870	COG0494	nUDIX hydrolase
G6545_RS23900	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
G6545_RS23905	COG2084	Dehydrogenase
G6545_RS23945	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
G6545_RS23950	COG0129	dihydroxy-acid dehydratase activity
G6545_RS23955	COG4654	Cytochrome c, class I
G6545_RS23960	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
G6545_RS24010	COG1473	amidohydrolase
G6545_RS24015	COG0418	dihydroorotase activity
G6545_RS24030	COG2001	Belongs to the MraZ family
G6545_RS24035	COG0275	rRNA processing
G6545_RS24040	COG3116	cell division
G6545_RS24050	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
G6545_RS24055	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
G6545_RS24060	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
G6545_RS24070	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
G6545_RS24080	COG1181	Belongs to the D-alanine--D-alanine ligase family
G6545_RS24085	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
G6545_RS24095	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
G6545_RS24100	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
G6545_RS24110	COG0739	heme binding
G6545_RS24115	COG0653	protein targeting
G6545_RS24135	COG1028	Short-chain dehydrogenase reductase Sdr
G6545_RS24140	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G6545_RS24145	COG1522	sequence-specific DNA binding
G6545_RS24160	COG2239	Acts as a magnesium transporter
G6545_RS24170	COG2855	membrane
G6545_RS24180	COG1473	amidohydrolase
G6545_RS24185	COG0318	PFAM AMP-dependent synthetase and ligase
G6545_RS24195	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
G6545_RS24195	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G6545_RS24200	COG1501	Belongs to the glycosyl hydrolase 31 family
G6545_RS24205	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
G6545_RS24210	COG2011	ABC-type metal ion transport system permease component
G6545_RS24225	COG1454	alcohol dehydrogenase
G6545_RS24245	COG2186	Transcriptional regulator
G6545_RS24250	COG3181	Tripartite tricarboxylate transporter family receptor
G6545_RS24265	COG1175	transmembrane transport
G6545_RS24270	COG0395	ABC-type sugar transport system, permease component
G6545_RS24275	COG3842	ATPase activity
G6545_RS24280	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
G6545_RS24285	COG1653	transport
G6545_RS24305	COG2818	Glycosylase
G6545_RS24310	COG2982	Protein involved in outer membrane biogenesis
G6545_RS24315	COG1309	transcriptional regulator
G6545_RS24320	COG1028	Short-chain dehydrogenase reductase Sdr