locus-tag	class	description
CAL12_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CAL12_RS00025	COG0583	DNA-binding transcription factor activity
CAL12_RS00050	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
CAL12_RS00055	COG1960	acyl-CoA dehydrogenase activity
CAL12_RS00065	COG0583	DNA-binding transcription factor activity
CAL12_RS00070	COG0583	DNA-binding transcription factor activity
CAL12_RS00080	COG2175	clavaminate synthase activity
CAL12_RS00110	COG4566	intracellular signal transduction
CAL12_RS00120	COG4948	Mandelate Racemase Muconate Lactonizing
CAL12_RS00130	COG3181	Tripartite tricarboxylate transporter family receptor
CAL12_RS00150	COG0318	PFAM AMP-dependent synthetase and ligase
CAL12_RS00205	COG1573	uracil-dna glycosylase
CAL12_RS00235	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
CAL12_RS00240	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CAL12_RS00275	COG0457	Tetratricopeptide repeat
CAL12_RS00280	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
CAL12_RS00285	COG1215	transferase activity, transferring glycosyl groups
CAL12_RS00290	COG1215	transferase activity, transferring glycosyl groups
CAL12_RS00295	COG2894	cell division
CAL12_RS00320	COG0411	ABC transporter
CAL12_RS00335	COG0683	leucine binding
CAL12_RS00340	COG0154	amidase activity
CAL12_RS00345	COG0583	DNA-binding transcription factor activity
CAL12_RS00350	COG0252	asparaginase activity
CAL12_RS00365	COG0411	ABC transporter
CAL12_RS00375	COG0683	leucine binding
CAL12_RS00385	COG4948	Mandelate Racemase Muconate Lactonizing
CAL12_RS00395	COG1254	Belongs to the acylphosphatase family
CAL12_RS00400	COG0657	acetylesterase activity
CAL12_RS00415	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CAL12_RS00430	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CAL12_RS00440	COG1522	sequence-specific DNA binding
CAL12_RS00445	COG0028	Belongs to the TPP enzyme family
CAL12_RS00450	COG1012	belongs to the aldehyde dehydrogenase family
CAL12_RS00465	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CAL12_RS00470	COG2922	Belongs to the Smg family
CAL12_RS00480	COG1126	abc transporter atp-binding protein
CAL12_RS00485	COG0765	amino acid transport
CAL12_RS00490	COG0765	amino acid transport
CAL12_RS00495	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CAL12_RS00505	COG2186	Transcriptional regulator
CAL12_RS00510	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CAL12_RS00520	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CAL12_RS00530	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CAL12_RS00535	COG0183	Belongs to the thiolase family
CAL12_RS00540	COG1960	acyl-CoA dehydrogenase activity
CAL12_RS00550	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CAL12_RS00560	COG1280	lysine exporter protein (LysE YggA)
CAL12_RS00565	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CAL12_RS00575	COG0018	arginyl-trna synthetase
CAL12_RS00595	COG0154	amidase activity
CAL12_RS00605	COG1840	ABC-type Fe3 transport system, periplasmic component
CAL12_RS00620	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CAL12_RS00625	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CAL12_RS00630	COG3842	ATPase activity
CAL12_RS00635	COG1653	transport
CAL12_RS00650	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CAL12_RS00660	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CAL12_RS00670	COG0583	DNA-binding transcription factor activity
CAL12_RS00690	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CAL12_RS00695	COG1280	lysine exporter protein (LysE YggA)
CAL12_RS00700	COG0513	Belongs to the DEAD box helicase family
CAL12_RS00710	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CAL12_RS00745	COG0625	glutathione transferase activity
CAL12_RS00750	COG2857	Cytochrome c1
CAL12_RS00755	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CAL12_RS00760	COG0723	plastoquinol--plastocyanin reductase activity
CAL12_RS00765	COG1970	mechanosensitive ion channel activity
CAL12_RS00770	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CAL12_RS00775	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CAL12_RS00790	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CAL12_RS00795	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CAL12_RS00800	COG0537	adenosine 5'-monophosphoramidase activity
CAL12_RS00805	COG0140	phosphoribosyl-ATP diphosphatase activity
CAL12_RS00815	COG0107	imidazoleglycerol-phosphate synthase activity
CAL12_RS00820	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CAL12_RS00830	COG0131	Imidazoleglycerol-phosphate dehydratase
CAL12_RS00835	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CAL12_RS00840	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CAL12_RS00850	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CAL12_RS00860	COG0842	Transport permease protein
CAL12_RS00865	COG1131	(ABC) transporter
CAL12_RS00875	COG2853	Lipoprotein
CAL12_RS00880	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CAL12_RS00885	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CAL12_RS00890	COG1127	ABC transporter
CAL12_RS00900	COG2059	Chromate
CAL12_RS00905	COG3047	cAMP biosynthetic process
CAL12_RS00910	COG2814	Major facilitator Superfamily
CAL12_RS00920	COG0070	glutamate synthase
CAL12_RS00920	COG0069	glutamate synthase activity
CAL12_RS00920	COG0067	glutamate synthase
CAL12_RS00935	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
CAL12_RS00950	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CAL12_RS00960	COG1609	Transcriptional regulator
CAL12_RS00965	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CAL12_RS00970	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CAL12_RS00975	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CAL12_RS00980	COG0129	dihydroxy-acid dehydratase activity
CAL12_RS00985	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
CAL12_RS00995	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CAL12_RS01025	COG1612	heme a metabolic process
CAL12_RS01035	COG1999	signal sequence binding
CAL12_RS01055	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CAL12_RS01060	COG2814	Major facilitator Superfamily
CAL12_RS01075	COG1522	sequence-specific DNA binding
CAL12_RS01110	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CAL12_RS01110	COG2010	Cytochrome c
CAL12_RS01115	COG1335	isochorismatase
CAL12_RS01120	COG2309	aminopeptidase activity
CAL12_RS01125	COG0596	Alpha beta hydrolase
CAL12_RS01130	COG3473	Maleate cis-trans isomerase
CAL12_RS01140	COG2080	2 iron, 2 sulfur cluster binding
CAL12_RS01145	COG2010	Cytochrome c
CAL12_RS01145	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CAL12_RS01150	COG0477	Major facilitator Superfamily
CAL12_RS01155	COG1846	Transcriptional regulator
CAL12_RS01160	COG1802	Transcriptional regulator
CAL12_RS01175	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CAL12_RS01230	COG0765	amino acid transport
CAL12_RS01235	COG1126	abc transporter atp-binding protein
CAL12_RS01240	COG5001	Diguanylate cyclase
CAL12_RS01240	COG5002	protein histidine kinase activity
CAL12_RS01250	COG0477	Major facilitator Superfamily
CAL12_RS01265	COG0066	3-isopropylmalate dehydratase activity
CAL12_RS01270	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CAL12_RS01275	COG2188	Transcriptional regulator
CAL12_RS01290	COG0300	oxidoreductase activity
CAL12_RS01295	COG2814	Major facilitator Superfamily
CAL12_RS01300	COG4977	sequence-specific DNA binding
CAL12_RS01315	COG2188	Transcriptional regulator
CAL12_RS01330	COG1396	sequence-specific DNA binding
CAL12_RS01335	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CAL12_RS01340	COG0765	amino acid transport
CAL12_RS01345	COG1126	abc transporter atp-binding protein
CAL12_RS01350	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CAL12_RS01355	COG1178	ABC-type Fe3 transport system permease component
CAL12_RS01360	COG3842	ATPase activity
CAL12_RS01365	COG1176	ABC-type spermidine putrescine transport system, permease component I
CAL12_RS01370	COG0402	S-adenosylhomocysteine deaminase activity
CAL12_RS01390	COG0318	PFAM AMP-dependent synthetase and ligase
CAL12_RS01400	COG1960	acyl-CoA dehydrogenase activity
CAL12_RS01405	COG1960	acyl-CoA dehydrogenase activity
CAL12_RS01410	COG1028	Short-chain dehydrogenase reductase Sdr
CAL12_RS01415	COG2030	dehydratase
CAL12_RS01445	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CAL12_RS01465	COG1414	Transcriptional regulator
CAL12_RS01485	COG2124	cytochrome p450
CAL12_RS01550	COG2132	Multicopper oxidase
CAL12_RS01555	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
CAL12_RS01560	COG1074	ATP-dependent DNA helicase activity
CAL12_RS01565	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CAL12_RS01580	COG3181	Tripartite tricarboxylate transporter family receptor
CAL12_RS01595	COG1028	Short-chain dehydrogenase reductase Sdr
CAL12_RS01625	COG1666	GTP binding
CAL12_RS01635	COG4208	sulfate ABC transporter
CAL12_RS01640	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
CAL12_RS01650	COG2816	NAD+ diphosphatase activity
CAL12_RS01660	COG2823	Periplasmic or secreted lipoprotein
CAL12_RS01665	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CAL12_RS01675	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CAL12_RS01685	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CAL12_RS01690	COG1660	Displays ATPase and GTPase activities
CAL12_RS01705	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CAL12_RS01715	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CAL12_RS01720	COG1137	ATPase activity
CAL12_RS01745	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
CAL12_RS01750	COG0747	negative chemotaxis
CAL12_RS01765	COG1250	3-hydroxyacyl-CoA dehydrogenase
CAL12_RS01770	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CAL12_RS01775	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CAL12_RS01780	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CAL12_RS01785	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CAL12_RS01790	COG0142	geranyltranstransferase activity
CAL12_RS01800	COG0861	Integral membrane protein TerC family
CAL12_RS01805	COG4106	trans-aconitate 2-methyltransferase activity
CAL12_RS01815	COG3403	YqcI/YcgG family
CAL12_RS01830	COG4977	sequence-specific DNA binding
CAL12_RS01850	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CAL12_RS01875	COG1053	succinate dehydrogenase
CAL12_RS01880	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CAL12_RS01895	COG2814	Major facilitator Superfamily
CAL12_RS01905	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
CAL12_RS01925	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CAL12_RS01935	COG0583	DNA-binding transcription factor activity
CAL12_RS01940	COG0583	DNA-binding transcription factor activity
CAL12_RS01965	COG0058	SHG alpha-glucan phosphorylase activity
CAL12_RS02020	COG3712	iron ion homeostasis
CAL12_RS02025	COG1595	DNA-templated transcription, initiation
CAL12_RS02035	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CAL12_RS02040	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CAL12_RS02045	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CAL12_RS02050	COG2175	clavaminate synthase activity
CAL12_RS02075	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CAL12_RS02080	COG1028	Short-chain dehydrogenase reductase Sdr
CAL12_RS02095	COG3181	Tripartite tricarboxylate transporter family receptor
CAL12_RS02105	COG1414	Transcriptional regulator
CAL12_RS02130	COG0471	metal ion transport
CAL12_RS02145	COG0583	DNA-binding transcription factor activity
CAL12_RS02150	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CAL12_RS02180	COG1028	Short-chain dehydrogenase reductase Sdr
CAL12_RS02210	COG0326	Molecular chaperone. Has ATPase activity
CAL12_RS02215	COG2271	Major facilitator Superfamily
CAL12_RS02220	COG4948	Mandelate Racemase Muconate Lactonizing
CAL12_RS02225	COG0800	Aldolase
CAL12_RS02230	COG3734	2-keto-3-deoxy-galactonokinase
CAL12_RS02235	COG1414	Transcriptional regulator
CAL12_RS02250	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CAL12_RS02255	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CAL12_RS02270	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CAL12_RS02285	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CAL12_RS02290	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
CAL12_RS02300	COG2175	clavaminate synthase activity
CAL12_RS02340	COG3550	peptidyl-serine autophosphorylation
CAL12_RS02360	COG0318	PFAM AMP-dependent synthetase and ligase
CAL12_RS02365	COG3842	ATPase activity
CAL12_RS02380	COG1176	ABC-type spermidine putrescine transport system, permease component I
CAL12_RS02390	COG1012	belongs to the aldehyde dehydrogenase family
CAL12_RS02395	COG0583	DNA-binding transcription factor activity
CAL12_RS02410	COG0747	negative chemotaxis
CAL12_RS02420	COG4608	Belongs to the ABC transporter superfamily
CAL12_RS02425	COG0444	Belongs to the ABC transporter superfamily
CAL12_RS02435	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CAL12_RS02450	COG0501	Belongs to the peptidase M48B family
CAL12_RS02455	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CAL12_RS02465	COG1116	anion transmembrane transporter activity
CAL12_RS02470	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CAL12_RS02490	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CAL12_RS02500	COG2175	clavaminate synthase activity
CAL12_RS02510	COG2226	methyltransferase
CAL12_RS02520	COG0583	DNA-binding transcription factor activity
CAL12_RS02525	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CAL12_RS02540	COG2264	protein methyltransferase activity
CAL12_RS02545	COG0531	amino acid
CAL12_RS02560	COG1012	belongs to the aldehyde dehydrogenase family
CAL12_RS02570	COG0583	DNA-binding transcription factor activity
CAL12_RS02585	COG1054	Belongs to the UPF0176 family
CAL12_RS02590	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CAL12_RS02620	COG0717	Belongs to the dCTP deaminase family
CAL12_RS02640	COG2081	HI0933 family
CAL12_RS02650	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CAL12_RS02655	COG0509	glycine decarboxylation via glycine cleavage system
CAL12_RS02660	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CAL12_RS02660	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CAL12_RS02670	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CAL12_RS02675	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CAL12_RS02685	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CAL12_RS02700	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CAL12_RS02715	COG0277	FAD linked oxidase domain protein
CAL12_RS02725	COG2205	protein histidine kinase activity
CAL12_RS02735	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CAL12_RS02735	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CAL12_RS02745	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CAL12_RS02750	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CAL12_RS02755	COG2186	Transcriptional regulator
CAL12_RS02760	COG0179	Fumarylacetoacetate (FAA) hydrolase
CAL12_RS02765	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
CAL12_RS02775	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CAL12_RS02785	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
CAL12_RS02790	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CAL12_RS02800	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CAL12_RS02810	COG0193	aminoacyl-tRNA hydrolase activity
CAL12_RS02825	COG0493	'glutamate synthase
CAL12_RS02825	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CAL12_RS02830	COG0012	GTP binding
CAL12_RS02840	COG2272	Belongs to the type-B carboxylesterase lipase family
CAL12_RS02860	COG0583	DNA-binding transcription factor activity
CAL12_RS02875	COG3119	arylsulfatase activity
CAL12_RS02880	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CAL12_RS02885	COG2814	Major facilitator Superfamily
CAL12_RS02890	COG1538	Outer membrane efflux protein
CAL12_RS02895	COG0842	Transport permease protein
CAL12_RS02900	COG0842	Transport permease protein
CAL12_RS02905	COG1131	(ABC) transporter
CAL12_RS02915	COG1309	transcriptional regulator
CAL12_RS02930	COG3135	benzoate transporter
CAL12_RS02935	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CAL12_RS02940	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CAL12_RS02945	COG0742	ribosomal rna small subunit methyltransferase
CAL12_RS02955	COG3025	triphosphatase activity
CAL12_RS02965	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CAL12_RS02970	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CAL12_RS02980	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CAL12_RS02990	COG0284	orotidine-5'-phosphate decarboxylase activity
CAL12_RS03010	COG1063	alcohol dehydrogenase
CAL12_RS03015	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CAL12_RS03025	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CAL12_RS03030	COG1028	Short-chain dehydrogenase reductase Sdr
CAL12_RS03035	COG0179	Fumarylacetoacetate (FAA) hydrolase
CAL12_RS03040	COG2721	sulfolactate sulfo-lyase activity
CAL12_RS03050	COG4166	transmembrane transport
CAL12_RS03090	COG0747	negative chemotaxis
CAL12_RS03100	COG0459	protein refolding
CAL12_RS03105	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CAL12_RS03120	COG0402	S-adenosylhomocysteine deaminase activity
CAL12_RS03145	COG1802	Transcriptional regulator
CAL12_RS03155	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CAL12_RS03160	COG4172	Belongs to the ABC transporter superfamily
CAL12_RS03165	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CAL12_RS03170	COG0601	transmembrane transport
CAL12_RS03175	COG0747	negative chemotaxis
CAL12_RS03190	COG1176	ABC-type spermidine putrescine transport system, permease component I
CAL12_RS03200	COG3842	ATPase activity
CAL12_RS03205	COG2351	hydroxyisourate hydrolase activity
CAL12_RS03210	COG0583	DNA-binding transcription factor activity
CAL12_RS03225	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CAL12_RS03230	COG4670	ketone body catabolic process
CAL12_RS03235	COG1309	transcriptional regulator
CAL12_RS03245	COG3842	ATPase activity
CAL12_RS03255	COG1175	transmembrane transport
CAL12_RS03260	COG0395	ABC-type sugar transport system, permease component
CAL12_RS03265	COG1671	Belongs to the UPF0178 family
CAL12_RS03295	COG3181	Tripartite tricarboxylate transporter family receptor
CAL12_RS03325	COG1250	3-hydroxyacyl-CoA dehydrogenase
CAL12_RS03325	COG1024	Enoyl-CoA hydratase
CAL12_RS03355	COG0477	Major facilitator Superfamily
CAL12_RS03370	COG0583	DNA-binding transcription factor activity
CAL12_RS03420	COG3181	Tripartite tricarboxylate transporter family receptor
CAL12_RS03425	COG0154	amidase activity
CAL12_RS03465	COG0251	oxidation-reduction process
CAL12_RS03470	COG2814	Major facilitator Superfamily
CAL12_RS03480	COG1028	Short-chain dehydrogenase reductase Sdr
CAL12_RS03485	COG1028	Short-chain dehydrogenase reductase Sdr
CAL12_RS03505	COG1609	Transcriptional regulator
CAL12_RS03550	COG3321	synthase
CAL12_RS03550	COG1028	Short-chain dehydrogenase reductase Sdr
CAL12_RS03550	COG0604	alcohol dehydrogenase
CAL12_RS03570	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CAL12_RS03575	COG0513	Belongs to the DEAD box helicase family
CAL12_RS03585	COG0861	Integral membrane protein TerC family
CAL12_RS03600	COG0443	Heat shock 70 kDa protein
CAL12_RS03620	COG2204	response regulator
CAL12_RS03625	COG2205	protein histidine kinase activity
CAL12_RS03630	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CAL12_RS03650	COG0784	Response regulator, receiver
CAL12_RS03650	COG4191	Histidine kinase
CAL12_RS03655	COG2986	histidine ammonia-lyase
CAL12_RS03675	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CAL12_RS03680	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CAL12_RS03695	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CAL12_RS03700	COG1414	Transcriptional regulator
CAL12_RS03710	COG1028	Short-chain dehydrogenase reductase Sdr
CAL12_RS03715	COG2814	Major facilitator Superfamily
CAL12_RS03725	COG0747	negative chemotaxis
CAL12_RS03730	COG2936	dipeptidyl-peptidase activity
CAL12_RS03740	COG0583	DNA-binding transcription factor activity
CAL12_RS03760	COG0583	DNA-binding transcription factor activity
CAL12_RS03765	COG1028	Short-chain dehydrogenase reductase Sdr
CAL12_RS03775	COG0583	DNA-binding transcription factor activity
CAL12_RS03780	COG3437	response regulator, receiver
CAL12_RS03785	COG0784	Response regulator, receiver
CAL12_RS03785	COG2198	Histidine kinase
CAL12_RS03785	COG5002	protein histidine kinase activity
CAL12_RS03805	COG0411	ABC transporter
CAL12_RS03825	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CAL12_RS03840	COG0154	amidase activity
CAL12_RS03850	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CAL12_RS03855	COG2271	Major facilitator Superfamily
CAL12_RS03865	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CAL12_RS03885	COG0179	Fumarylacetoacetate (FAA) hydrolase
CAL12_RS03890	COG3971	2-oxopent-4-enoate hydratase activity
CAL12_RS03900	COG0514	ATP-dependent DNA helicase (RecQ)
CAL12_RS03905	COG0840	transmembrane signaling receptor activity
CAL12_RS03930	COG1335	isochorismatase
CAL12_RS03980	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CAL12_RS03995	COG4608	Belongs to the ABC transporter superfamily
CAL12_RS04000	COG0444	Belongs to the ABC transporter superfamily
CAL12_RS04005	COG0747	negative chemotaxis
CAL12_RS04035	COG0477	Major facilitator Superfamily
CAL12_RS04050	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
CAL12_RS04055	COG3842	ATPase activity
CAL12_RS04075	COG4948	Mandelate Racemase Muconate Lactonizing
CAL12_RS04085	COG0179	Fumarylacetoacetate (FAA) hydrolase
CAL12_RS04090	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CAL12_RS04095	COG4948	Mandelate Racemase Muconate Lactonizing
CAL12_RS04125	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CAL12_RS04130	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CAL12_RS04145	COG0583	DNA-binding transcription factor activity
CAL12_RS04160	COG0165	Argininosuccinate lyase
CAL12_RS04195	COG1573	uracil-dna glycosylase
CAL12_RS04230	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CAL12_RS04240	COG0583	DNA-binding transcription factor activity
CAL12_RS04245	COG1595	DNA-templated transcription, initiation
CAL12_RS04250	COG1566	PFAM secretion protein HlyD family protein
CAL12_RS04255	COG2814	Major facilitator Superfamily
CAL12_RS04285	COG2175	clavaminate synthase activity
CAL12_RS04290	COG0477	Major facilitator Superfamily
CAL12_RS04300	COG0583	DNA-binding transcription factor activity
CAL12_RS04315	COG0625	glutathione transferase activity
CAL12_RS04320	COG1595	DNA-templated transcription, initiation
CAL12_RS04325	COG3712	iron ion homeostasis
CAL12_RS04330	COG4774	siderophore transport
CAL12_RS04345	COG1280	lysine exporter protein (LysE YggA)
CAL12_RS04355	COG4297	protein containing double-stranded beta helix domain
CAL12_RS04365	COG0583	DNA-binding transcription factor activity
CAL12_RS04370	COG2223	nitrite transmembrane transporter activity
CAL12_RS04380	COG1595	DNA-templated transcription, initiation
CAL12_RS04405	COG1028	Short-chain dehydrogenase reductase Sdr
CAL12_RS04410	COG0183	Belongs to the thiolase family
CAL12_RS04425	COG0583	DNA-binding transcription factor activity
CAL12_RS04435	COG1028	Short-chain dehydrogenase reductase Sdr
CAL12_RS04440	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CAL12_RS04450	COG4774	siderophore transport
CAL12_RS04455	COG3128	pkhd-type hydroxylase
CAL12_RS04470	COG2084	Dehydrogenase
CAL12_RS04480	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CAL12_RS04490	COG1028	Short-chain dehydrogenase reductase Sdr
CAL12_RS04515	COG1028	Short-chain dehydrogenase reductase Sdr
CAL12_RS04520	COG0372	Belongs to the citrate synthase family
CAL12_RS04525	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CAL12_RS04530	COG3181	Tripartite tricarboxylate transporter family receptor
CAL12_RS04540	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CAL12_RS04555	COG2197	response regulator
CAL12_RS04560	COG2205	protein histidine kinase activity
CAL12_RS04560	COG0784	Response regulator, receiver
CAL12_RS04575	COG3121	Chaperone
CAL12_RS04595	COG0583	DNA-binding transcription factor activity
CAL12_RS04605	COG3321	synthase
CAL12_RS04605	COG1028	Short-chain dehydrogenase reductase Sdr
CAL12_RS04605	COG0604	alcohol dehydrogenase
CAL12_RS04610	COG0583	DNA-binding transcription factor activity
CAL12_RS04615	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CAL12_RS04620	COG3550	peptidyl-serine autophosphorylation
CAL12_RS04635	COG2271	Major facilitator Superfamily
CAL12_RS04640	COG1028	Short-chain dehydrogenase reductase Sdr
CAL12_RS04655	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CAL12_RS04670	COG0456	acetyltransferase
CAL12_RS04675	COG0583	DNA-binding transcription factor activity
CAL12_RS04680	COG1012	belongs to the aldehyde dehydrogenase family
CAL12_RS04695	COG0840	transmembrane signaling receptor activity
CAL12_RS04715	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CAL12_RS04720	COG0583	DNA-binding transcription factor activity
CAL12_RS04755	COG3706	GGDEF domain
CAL12_RS04760	COG1881	PFAM PEBP family protein
CAL12_RS04795	COG0156	8-amino-7-oxononanoate synthase activity
CAL12_RS04805	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CAL12_RS04850	COG0667	Aldo Keto reductase
CAL12_RS04855	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CAL12_RS04860	COG4535	Mg2 and Co2 transporter CorC
CAL12_RS04865	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CAL12_RS04870	COG1702	phosphate starvation-inducible protein PhoH
CAL12_RS04885	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CAL12_RS04920	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CAL12_RS04925	COG1862	Preprotein translocase
CAL12_RS04930	COG0343	queuine tRNA-ribosyltransferase activity
CAL12_RS04935	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CAL12_RS04940	COG2027	D-alanyl-D-alanine carboxypeptidase
CAL12_RS04945	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CAL12_RS04950	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CAL12_RS04950	COG1648	precorrin-2 dehydrogenase activity
CAL12_RS04960	COG4575	ribosome binding
CAL12_RS04975	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CAL12_RS04980	COG0741	lytic transglycosylase activity
CAL12_RS04985	COG0436	Aminotransferase
CAL12_RS04995	COG0281	malic enzyme
CAL12_RS04995	COG0280	phosphate acetyltransferase
CAL12_RS05005	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CAL12_RS05010	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CAL12_RS05015	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CAL12_RS05020	COG0126	phosphoglycerate kinase activity
CAL12_RS05025	COG0625	glutathione transferase activity
CAL12_RS05035	COG0484	heat shock protein binding
CAL12_RS05040	COG0521	Mo-molybdopterin cofactor biosynthetic process
CAL12_RS05055	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CAL12_RS05070	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CAL12_RS05075	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
CAL12_RS05080	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
CAL12_RS05085	COG3639	organic phosphonate transmembrane transporter activity
CAL12_RS05100	COG4948	Mandelate Racemase Muconate Lactonizing
CAL12_RS05120	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
CAL12_RS05125	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
CAL12_RS05130	COG3454	Phosphonate metabolism
CAL12_RS05135	COG2188	Transcriptional regulator
CAL12_RS05140	COG3624	Phosphonate C-P lyase system protein PhnG
CAL12_RS05145	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
CAL12_RS05150	COG3626	phosphonate metabolism
CAL12_RS05155	COG3627	carbon phosphorus lyase activity
CAL12_RS05160	COG4107	phosphonate C-P lyase system protein PhnK
CAL12_RS05165	COG4778	phosphonate C-P lyase system protein PhnL
CAL12_RS05170	COG3454	Phosphonate metabolism
CAL12_RS05180	COG2885	chlorophyll binding
CAL12_RS05215	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CAL12_RS05220	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CAL12_RS05225	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CAL12_RS05230	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CAL12_RS05235	COG0009	L-threonylcarbamoyladenylate synthase
CAL12_RS05240	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CAL12_RS05255	COG1172	Belongs to the binding-protein-dependent transport system permease family
CAL12_RS05280	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CAL12_RS05300	COG2030	dehydratase
CAL12_RS05340	COG1960	acyl-CoA dehydrogenase activity
CAL12_RS05345	COG0028	Belongs to the TPP enzyme family
CAL12_RS05365	COG0765	amino acid transport
CAL12_RS05370	COG0765	amino acid transport
CAL12_RS05375	COG1126	abc transporter atp-binding protein
CAL12_RS05385	COG0579	oxidoreductase
CAL12_RS05395	COG0259	pyridoxamine-phosphate oxidase activity
CAL12_RS05410	COG2205	protein histidine kinase activity
CAL12_RS05415	COG0745	RESPONSE REGULATOR receiver
CAL12_RS05420	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CAL12_RS05435	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CAL12_RS05440	COG1414	Transcriptional regulator
CAL12_RS05450	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CAL12_RS05460	COG0583	DNA-binding transcription factor activity
CAL12_RS05490	COG0488	(ABC) transporter
CAL12_RS05505	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CAL12_RS05510	COG2894	cell division
CAL12_RS05515	COG0850	regulation of cytokinetic process
CAL12_RS05525	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CAL12_RS05555	COG0514	ATP-dependent DNA helicase (RecQ)
CAL12_RS05565	COG2255	four-way junction helicase activity
CAL12_RS05575	COG1090	epimerase
CAL12_RS05580	COG0632	four-way junction helicase activity
CAL12_RS05605	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CAL12_RS05620	COG1079	Belongs to the binding-protein-dependent transport system permease family
CAL12_RS05625	COG4603	Belongs to the binding-protein-dependent transport system permease family
CAL12_RS05630	COG3845	ABC transporter
CAL12_RS05645	COG0583	DNA-binding transcription factor activity
CAL12_RS05650	COG0006	proline dipeptidase activity
CAL12_RS05665	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CAL12_RS05715	COG0513	Belongs to the DEAD box helicase family
CAL12_RS05735	COG1414	Transcriptional regulator
CAL12_RS05740	COG0154	amidase activity
CAL12_RS05745	COG3181	Tripartite tricarboxylate transporter family receptor
CAL12_RS05750	COG0583	DNA-binding transcription factor activity
CAL12_RS05765	COG0167	dihydroorotate dehydrogenase activity
CAL12_RS05770	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
CAL12_RS05775	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
CAL12_RS05800	COG0583	DNA-binding transcription factor activity
CAL12_RS05805	COG1028	Short-chain dehydrogenase reductase Sdr
CAL12_RS05810	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CAL12_RS05825	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CAL12_RS05830	COG3181	Tripartite tricarboxylate transporter family receptor
CAL12_RS05835	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CAL12_RS05845	COG0477	Major facilitator Superfamily
CAL12_RS05850	COG1434	Gram-negative-bacterium-type cell wall biogenesis
CAL12_RS05875	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CAL12_RS05880	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CAL12_RS05885	COG1414	Transcriptional regulator
CAL12_RS05930	COG1028	Short-chain dehydrogenase reductase Sdr
CAL12_RS05935	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CAL12_RS05940	COG1028	Short-chain dehydrogenase reductase Sdr
CAL12_RS05945	COG0179	Fumarylacetoacetate (FAA) hydrolase
CAL12_RS05950	COG4948	Mandelate Racemase Muconate Lactonizing
CAL12_RS05960	COG0583	DNA-binding transcription factor activity
CAL12_RS05965	COG2423	ornithine cyclodeaminase activity
CAL12_RS05975	COG0583	DNA-binding transcription factor activity
CAL12_RS06035	COG1028	Short-chain dehydrogenase reductase Sdr
CAL12_RS06055	COG3622	Belongs to the hyi family
CAL12_RS06070	COG0477	Major facilitator Superfamily
CAL12_RS06090	COG0583	DNA-binding transcription factor activity
CAL12_RS06115	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CAL12_RS06130	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CAL12_RS06130	COG0446	pyridine nucleotide-disulphide oxidoreductase
CAL12_RS06140	COG0405	Gamma-glutamyltransferase
CAL12_RS06145	COG3938	Belongs to the proline racemase family
CAL12_RS06155	COG3181	Tripartite tricarboxylate transporter family receptor
CAL12_RS06160	COG2084	Dehydrogenase
CAL12_RS06165	COG3622	Belongs to the hyi family
CAL12_RS06170	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CAL12_RS06190	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CAL12_RS06200	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CAL12_RS06205	COG0735	belongs to the Fur family
CAL12_RS06210	COG0497	DNA recombination
CAL12_RS06220	COG1420	regulation of RNA biosynthetic process
CAL12_RS06225	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CAL12_RS06230	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CAL12_RS06240	COG0443	Heat shock 70 kDa protein
CAL12_RS06245	COG0484	heat shock protein binding
CAL12_RS06250	COG3181	Tripartite tricarboxylate transporter family receptor
CAL12_RS06265	COG0154	amidase activity
CAL12_RS06270	COG3038	cytochrome b561
CAL12_RS06280	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CAL12_RS06295	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CAL12_RS06300	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CAL12_RS06305	COG1929	Belongs to the glycerate kinase type-1 family
CAL12_RS06310	COG0469	pyruvate kinase activity
CAL12_RS06315	COG0700	Nucleoside recognition
CAL12_RS06320	COG0242	peptide deformylase activity
CAL12_RS06340	COG0204	Acyl-transferase
CAL12_RS06345	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CAL12_RS06350	COG0751	glycine-tRNA ligase activity
CAL12_RS06355	COG0752	glycyl-tRNA synthetase alpha subunit
CAL12_RS06375	COG0617	tRNA 3'-terminal CCA addition
CAL12_RS06390	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CAL12_RS06395	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CAL12_RS06400	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CAL12_RS06405	COG0586	Pfam SNARE associated Golgi protein
CAL12_RS06410	COG0860	N-Acetylmuramoyl-L-alanine amidase
CAL12_RS06420	COG0114	fumarate hydratase activity
CAL12_RS06430	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CAL12_RS06445	COG1686	Belongs to the peptidase S11 family
CAL12_RS06465	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CAL12_RS06470	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CAL12_RS06475	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CAL12_RS06480	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CAL12_RS06485	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CAL12_RS06495	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CAL12_RS06500	COG0505	Belongs to the CarA family
CAL12_RS06505	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CAL12_RS06515	COG0300	oxidoreductase activity
CAL12_RS06520	COG0406	alpha-ribazole phosphatase activity
CAL12_RS06530	COG2233	PERMEase
CAL12_RS06535	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CAL12_RS06545	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
CAL12_RS06550	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CAL12_RS06560	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CAL12_RS06570	COG0248	Ppx GppA phosphatase
CAL12_RS06575	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CAL12_RS06595	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CAL12_RS06605	COG0235	Class ii aldolase
CAL12_RS06645	COG4773	Receptor
CAL12_RS06650	COG0735	belongs to the Fur family
CAL12_RS06655	COG2207	Transcriptional regulator
CAL12_RS06665	COG1942	4-Oxalocrotonate Tautomerase
CAL12_RS06670	COG0583	DNA-binding transcription factor activity
CAL12_RS06675	COG0583	DNA-binding transcription factor activity
CAL12_RS06710	COG1028	Short-chain dehydrogenase reductase Sdr
CAL12_RS06715	COG0753	catalase activity
CAL12_RS06720	COG3038	cytochrome b561
CAL12_RS06730	COG1760	l-serine dehydratase
CAL12_RS06740	COG1028	Short-chain dehydrogenase reductase Sdr
CAL12_RS06760	COG2146	nitrite reductase [NAD(P)H] activity
CAL12_RS06760	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CAL12_RS06765	COG2146	nitrite reductase [NAD(P)H] activity
CAL12_RS06765	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CAL12_RS06795	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
CAL12_RS06800	COG3181	Tripartite tricarboxylate transporter family receptor
CAL12_RS06810	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
CAL12_RS06815	COG0583	DNA-binding transcription factor activity
CAL12_RS06825	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CAL12_RS06850	COG1802	Transcriptional regulator
CAL12_RS06870	COG1137	ATPase activity
CAL12_RS06880	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CAL12_RS06885	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CAL12_RS06890	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CAL12_RS06900	COG0477	Major facilitator Superfamily
CAL12_RS06920	COG1201	RNA secondary structure unwinding
CAL12_RS06965	COG0523	cobalamin synthesis protein
CAL12_RS06970	COG2084	Dehydrogenase
CAL12_RS06975	COG3386	PFAM SMP-30 Gluconolaconase
CAL12_RS06980	COG3618	amidohydrolase
CAL12_RS06985	COG1028	Short-chain dehydrogenase reductase Sdr
CAL12_RS07010	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CAL12_RS07025	COG0243	molybdopterin cofactor binding
CAL12_RS07030	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CAL12_RS07035	COG1116	anion transmembrane transporter activity
CAL12_RS07040	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CAL12_RS07045	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CAL12_RS07060	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CAL12_RS07075	COG1609	Transcriptional regulator
CAL12_RS07085	COG3842	ATPase activity
CAL12_RS07090	COG1176	ABC-type spermidine putrescine transport system, permease component I
CAL12_RS07095	COG1177	transmembrane transport
CAL12_RS07125	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CAL12_RS07130	COG3181	Tripartite tricarboxylate transporter family receptor
CAL12_RS07135	COG1024	Enoyl-CoA hydratase
CAL12_RS07140	COG0583	DNA-binding transcription factor activity
CAL12_RS07185	COG0436	Aminotransferase
CAL12_RS07195	COG3842	ATPase activity
CAL12_RS07225	COG3685	Protein conserved in bacteria
CAL12_RS07240	COG3246	L-lysine catabolic process to acetate
CAL12_RS07270	COG1028	Short-chain dehydrogenase reductase Sdr
CAL12_RS07280	COG0784	Response regulator, receiver
CAL12_RS07280	COG4191	Histidine kinase
CAL12_RS07285	COG0431	NADPH-dependent FMN reductase
CAL12_RS07300	COG1116	anion transmembrane transporter activity
CAL12_RS07305	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CAL12_RS07310	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CAL12_RS07325	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CAL12_RS07380	COG2321	neutral zinc metallopeptidase
CAL12_RS07385	COG0009	L-threonylcarbamoyladenylate synthase
CAL12_RS07390	COG1994	Peptidase M50
CAL12_RS07395	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CAL12_RS07400	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
CAL12_RS07410	COG2850	peptidyl-arginine hydroxylation
CAL12_RS07415	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CAL12_RS07420	COG0583	DNA-binding transcription factor activity
CAL12_RS07445	COG0477	Major facilitator Superfamily
CAL12_RS07455	COG4221	oxidoreductase activity
CAL12_RS07465	COG0583	DNA-binding transcription factor activity
CAL12_RS07485	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CAL12_RS07490	COG0765	amino acid transport
CAL12_RS07495	COG0765	amino acid transport
CAL12_RS07500	COG1126	abc transporter atp-binding protein
CAL12_RS07530	COG2814	Major facilitator Superfamily
CAL12_RS07545	COG3360	Dodecin
CAL12_RS07550	COG0431	NADPH-dependent FMN reductase
CAL12_RS07560	COG0668	transmembrane transport
CAL12_RS07580	COG0483	inositol monophosphate 1-phosphatase activity
CAL12_RS07585	COG1253	flavin adenine dinucleotide binding
CAL12_RS07590	COG1968	undecaprenyl-diphosphatase activity
CAL12_RS07595	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CAL12_RS07600	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CAL12_RS07610	COG0215	cysteine-tRNA ligase activity
CAL12_RS07620	COG0825	malonyl-CoA metabolic process
CAL12_RS07665	COG0583	DNA-binding transcription factor activity
CAL12_RS07670	COG3181	Tripartite tricarboxylate transporter family receptor
CAL12_RS07705	COG2877	3-deoxy-8-phosphooctulonate synthase activity
CAL12_RS07710	COG0583	DNA-binding transcription factor activity
CAL12_RS07720	COG1028	Short-chain dehydrogenase reductase Sdr
CAL12_RS07725	COG0583	DNA-binding transcription factor activity
CAL12_RS07730	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CAL12_RS07735	COG0066	3-isopropylmalate dehydratase activity
CAL12_RS07745	COG2358	TRAP transporter, solute receptor (TAXI family
CAL12_RS07770	COG4772	TonB-dependent receptor
CAL12_RS07830	COG3181	Tripartite tricarboxylate transporter family receptor
CAL12_RS07845	COG1053	succinate dehydrogenase
CAL12_RS07855	COG0028	Belongs to the TPP enzyme family
CAL12_RS07860	COG3181	Tripartite tricarboxylate transporter family receptor
CAL12_RS07865	COG0583	DNA-binding transcription factor activity
CAL12_RS07875	COG3181	Tripartite tricarboxylate transporter family receptor
CAL12_RS07880	COG0583	DNA-binding transcription factor activity
CAL12_RS07890	COG2084	Dehydrogenase
CAL12_RS07895	COG0477	Major facilitator Superfamily
CAL12_RS07925	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CAL12_RS07930	COG0745	RESPONSE REGULATOR receiver
CAL12_RS07935	COG5002	protein histidine kinase activity
CAL12_RS07950	COG2197	response regulator
CAL12_RS07955	COG0297	glycogen (starch) synthase activity
CAL12_RS07960	COG0110	maltose O-acetyltransferase activity
CAL12_RS07965	COG0463	Glycosyl transferase, family 2
CAL12_RS07970	COG0438	transferase activity, transferring glycosyl groups
CAL12_RS07990	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CAL12_RS07995	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
CAL12_RS08005	COG1051	belongs to the nudix hydrolase family
CAL12_RS08010	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CAL12_RS08020	COG0489	protein tyrosine kinase activity
CAL12_RS08020	COG3206	protein involved in exopolysaccharide biosynthesis
CAL12_RS08030	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CAL12_RS08040	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CAL12_RS08045	COG1045	serine acetyltransferase
CAL12_RS08050	COG0483	inositol monophosphate 1-phosphatase activity
CAL12_RS08055	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CAL12_RS08090	COG0598	Magnesium transport protein CorA
CAL12_RS08105	COG0601	transmembrane transport
CAL12_RS08110	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CAL12_RS08115	COG4172	Belongs to the ABC transporter superfamily
CAL12_RS08145	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CAL12_RS08160	COG3181	Tripartite tricarboxylate transporter family receptor
CAL12_RS08165	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CAL12_RS08210	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CAL12_RS08215	COG2878	Part of a membrane complex involved in electron transport
CAL12_RS08240	COG0251	oxidation-reduction process
CAL12_RS08245	COG3228	Belongs to the MtfA family
CAL12_RS08250	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CAL12_RS08265	COG0159	tryptophan synthase activity
CAL12_RS08270	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CAL12_RS08275	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CAL12_RS08290	COG1028	Short-chain dehydrogenase reductase Sdr
CAL12_RS08295	COG0583	DNA-binding transcription factor activity
CAL12_RS08300	COG1530	ribonuclease E activity
CAL12_RS08310	COG0546	phosphoglycolate phosphatase activity
CAL12_RS08315	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CAL12_RS08320	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
CAL12_RS08325	COG3023	N-Acetylmuramoyl-L-alanine amidase
CAL12_RS08335	COG0424	maF-like protein
CAL12_RS08345	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CAL12_RS08355	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CAL12_RS08360	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CAL12_RS08365	COG1028	Short-chain dehydrogenase reductase Sdr
CAL12_RS08370	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CAL12_RS08375	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CAL12_RS08400	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CAL12_RS08405	COG0481	GTPase activity
CAL12_RS08410	COG0681	Belongs to the peptidase S26 family
CAL12_RS08415	COG0571	ribonuclease III activity
CAL12_RS08420	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CAL12_RS08425	COG1381	Involved in DNA repair and RecF pathway recombination
CAL12_RS08455	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CAL12_RS08480	COG0583	DNA-binding transcription factor activity
CAL12_RS08495	COG0791	NLP P60 protein
CAL12_RS08505	COG3193	protein, possibly involved in utilization of glycolate and propanediol
CAL12_RS08515	COG3938	Belongs to the proline racemase family
CAL12_RS08520	COG1704	LemA family
CAL12_RS08540	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CAL12_RS08545	COG0697	spore germination
CAL12_RS08550	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
CAL12_RS08585	COG3568	Endonuclease Exonuclease Phosphatase
CAL12_RS08590	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CAL12_RS08595	COG0392	lysyltransferase activity
CAL12_RS08605	COG1446	asparaginase
CAL12_RS08610	COG4172	Belongs to the ABC transporter superfamily
CAL12_RS08615	COG0747	negative chemotaxis
CAL12_RS08645	COG0504	CTP synthase activity
CAL12_RS08650	COG0148	phosphopyruvate hydratase activity
CAL12_RS08655	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
CAL12_RS08665	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CAL12_RS08695	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CAL12_RS08700	COG1984	allophanate hydrolase subunit 2
CAL12_RS08710	COG1981	membrane
CAL12_RS08715	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CAL12_RS08730	COG0495	leucyl-tRNA aminoacylation
CAL12_RS08745	COG1764	response to oxidative stress
CAL12_RS08750	COG1846	Transcriptional regulator
CAL12_RS08755	COG1802	Transcriptional regulator
CAL12_RS08765	COG3181	Tripartite tricarboxylate transporter family receptor
CAL12_RS08780	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CAL12_RS08785	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CAL12_RS08790	COG2814	Major facilitator Superfamily
CAL12_RS08795	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CAL12_RS08805	COG0183	Belongs to the thiolase family
CAL12_RS08815	COG1802	Transcriptional regulator
CAL12_RS08830	COG0318	PFAM AMP-dependent synthetase and ligase
CAL12_RS08850	COG4120	Belongs to the binding-protein-dependent transport system permease family
CAL12_RS08865	COG0745	RESPONSE REGULATOR receiver
CAL12_RS08870	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CAL12_RS08875	COG0736	holo-[acyl-carrier-protein] synthase activity
CAL12_RS08885	COG0322	excinuclease ABC activity
CAL12_RS08895	COG4948	Mandelate Racemase Muconate Lactonizing
CAL12_RS08900	COG3181	Tripartite tricarboxylate transporter family receptor
CAL12_RS08905	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CAL12_RS08905	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CAL12_RS08910	COG1131	(ABC) transporter
CAL12_RS08915	COG0842	Transport permease protein
CAL12_RS08920	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CAL12_RS08945	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CAL12_RS08950	COG0642	Histidine kinase
CAL12_RS08965	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
CAL12_RS08990	COG1174	glycine betaine transport
CAL12_RS08995	COG3181	Tripartite tricarboxylate transporter family receptor
CAL12_RS09030	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CAL12_RS09040	COG0542	response to heat
CAL12_RS09045	COG0028	Belongs to the TPP enzyme family
CAL12_RS09050	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CAL12_RS09055	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CAL12_RS09065	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CAL12_RS09090	COG0456	acetyltransferase
CAL12_RS09105	COG5285	phytanoyl-CoA dioxygenase
CAL12_RS09110	COG0633	Ferredoxin
CAL12_RS09110	COG3217	Mosc domain protein beta barrel domain protein
CAL12_RS09120	COG0543	2 iron, 2 sulfur cluster binding
CAL12_RS09120	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CAL12_RS09125	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CAL12_RS09130	COG1653	transport
CAL12_RS09155	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
CAL12_RS09175	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CAL12_RS09180	COG0425	Belongs to the sulfur carrier protein TusA family
CAL12_RS09185	COG0228	four-way junction DNA binding
CAL12_RS09190	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CAL12_RS09195	COG0336	Belongs to the RNA methyltransferase TrmD family
CAL12_RS09200	COG0525	valine-tRNA ligase activity
CAL12_RS09205	COG0105	UTP biosynthetic process
CAL12_RS09210	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CAL12_RS09230	COG2976	Protein conserved in bacteria
CAL12_RS09235	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CAL12_RS09240	COG1160	GTP binding
CAL12_RS09250	COG1923	regulation of RNA biosynthetic process
CAL12_RS09255	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CAL12_RS09260	COG0330	HflC and HflK could
CAL12_RS09265	COG0330	HflC and HflK could
CAL12_RS09270	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
CAL12_RS09275	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CAL12_RS09285	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CAL12_RS09295	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CAL12_RS09315	COG1574	metal-dependent hydrolase with the TIM-barrel fold
CAL12_RS09335	COG1297	OPT oligopeptide transporter protein
CAL12_RS09345	COG1686	Belongs to the peptidase S11 family
CAL12_RS09350	COG2423	ornithine cyclodeaminase activity
CAL12_RS09360	COG2814	Major facilitator Superfamily
CAL12_RS09380	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CAL12_RS09390	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
CAL12_RS09435	COG2814	Major facilitator Superfamily
CAL12_RS09440	COG0540	Belongs to the ATCase OTCase family
CAL12_RS09460	COG0477	Major facilitator Superfamily
CAL12_RS09475	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CAL12_RS09480	COG2137	regulation of response to DNA damage stimulus
CAL12_RS09485	COG0583	DNA-binding transcription factor activity
CAL12_RS09500	COG0045	succinate-CoA ligase (ADP-forming) activity
CAL12_RS09505	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CAL12_RS09510	COG0861	Integral membrane protein TerC family
CAL12_RS09515	COG0861	Integral membrane protein TerC family
CAL12_RS09520	COG0181	hydroxymethylbilane synthase activity
CAL12_RS09540	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CAL12_RS09610	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CAL12_RS09615	COG0517	IMP dehydrogenase activity
CAL12_RS09615	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CAL12_RS09620	COG1295	ribonuclease BN
CAL12_RS09630	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CAL12_RS09635	COG0745	RESPONSE REGULATOR receiver
CAL12_RS09640	COG5002	protein histidine kinase activity
CAL12_RS09655	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CAL12_RS09670	COG0066	3-isopropylmalate dehydratase activity
CAL12_RS09680	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CAL12_RS09695	COG0135	phosphoribosylanthranilate isomerase activity
CAL12_RS09730	COG2200	EAL domain
CAL12_RS09740	COG0784	Response regulator, receiver
CAL12_RS09740	COG2205	protein histidine kinase activity
CAL12_RS09745	COG2197	response regulator
CAL12_RS09750	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CAL12_RS09755	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CAL12_RS09770	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CAL12_RS09775	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CAL12_RS09780	COG0405	Gamma-glutamyltransferase
CAL12_RS09790	COG3181	Tripartite tricarboxylate transporter family receptor
CAL12_RS09795	COG0583	DNA-binding transcription factor activity
CAL12_RS09800	COG4608	Belongs to the ABC transporter superfamily
CAL12_RS09810	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CAL12_RS09815	COG0601	transmembrane transport
CAL12_RS09820	COG0747	negative chemotaxis
CAL12_RS09835	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CAL12_RS09840	COG4988	ABC transporter
CAL12_RS09845	COG1271	oxidase subunit
CAL12_RS09850	COG1294	oxidase, subunit
CAL12_RS09865	COG1028	Short-chain dehydrogenase reductase Sdr
CAL12_RS09870	COG0004	ammonium transporteR
CAL12_RS09925	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CAL12_RS09930	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CAL12_RS09935	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CAL12_RS09940	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CAL12_RS09940	COG0072	phenylalanine-tRNA ligase activity
CAL12_RS09965	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CAL12_RS10020	COG3181	Tripartite tricarboxylate transporter family receptor
CAL12_RS10040	COG0583	DNA-binding transcription factor activity
CAL12_RS10055	COG5265	(ABC) transporter
CAL12_RS10060	COG0583	DNA-binding transcription factor activity
CAL12_RS10070	COG0154	amidase activity
CAL12_RS10090	COG4977	sequence-specific DNA binding
CAL12_RS10090	COG1917	Cupin 2, conserved barrel domain protein
CAL12_RS10095	COG2223	nitrite transmembrane transporter activity
CAL12_RS10130	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CAL12_RS10135	COG1028	Short-chain dehydrogenase reductase Sdr
CAL12_RS10145	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CAL12_RS10185	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CAL12_RS10195	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CAL12_RS10200	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CAL12_RS10205	COG0204	Acyl-transferase
CAL12_RS10225	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CAL12_RS10235	COG0587	DNA-directed DNA polymerase activity
CAL12_RS10255	COG1695	Transcriptional regulator
CAL12_RS10260	COG2375	cellular response to nickel ion
CAL12_RS10270	COG3618	amidohydrolase
CAL12_RS10280	COG1802	Transcriptional regulator
CAL12_RS10285	COG0583	DNA-binding transcription factor activity
CAL12_RS10290	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CAL12_RS10295	COG2814	Major facilitator Superfamily
CAL12_RS10300	COG3608	succinylglutamate desuccinylase aspartoacylase
CAL12_RS10330	COG2814	Major facilitator Superfamily
CAL12_RS10335	COG1335	isochorismatase
CAL12_RS10340	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CAL12_RS10375	COG2309	aminopeptidase activity
CAL12_RS10380	COG0596	Alpha beta hydrolase
CAL12_RS10400	COG0653	protein targeting
CAL12_RS10430	COG4149	molybdate abc transporter
CAL12_RS10435	COG1176	ABC-type spermidine putrescine transport system, permease component I
CAL12_RS10440	COG3842	ATPase activity
CAL12_RS10445	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CAL12_RS10470	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CAL12_RS10480	COG3842	ATPase activity
CAL12_RS10510	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CAL12_RS10520	COG2372	response to copper ion
CAL12_RS10535	COG0583	DNA-binding transcription factor activity
CAL12_RS10540	COG1028	Short-chain dehydrogenase reductase Sdr
CAL12_RS10545	COG0656	L-ascorbic acid biosynthetic process
CAL12_RS10550	COG1012	belongs to the aldehyde dehydrogenase family
CAL12_RS10565	COG1414	Transcriptional regulator
CAL12_RS10570	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CAL12_RS10575	COG4221	oxidoreductase activity
CAL12_RS10580	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
CAL12_RS10585	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CAL12_RS10615	COG0583	DNA-binding transcription factor activity
CAL12_RS10635	COG0583	DNA-binding transcription factor activity
CAL12_RS10645	COG3181	Tripartite tricarboxylate transporter family receptor
CAL12_RS10650	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CAL12_RS10655	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CAL12_RS10670	COG1028	Short-chain dehydrogenase reductase Sdr
CAL12_RS10675	COG0693	protein deglycase activity
CAL12_RS10680	COG0583	DNA-binding transcription factor activity
CAL12_RS10700	COG2814	Major facilitator Superfamily
CAL12_RS10725	COG1129	ABC transporter
CAL12_RS10740	COG1201	RNA secondary structure unwinding
CAL12_RS10745	COG0583	DNA-binding transcription factor activity
CAL12_RS10760	COG0765	amino acid transport
CAL12_RS10765	COG0765	amino acid transport
CAL12_RS10770	COG1126	abc transporter atp-binding protein
CAL12_RS10775	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CAL12_RS10785	COG0656	L-ascorbic acid biosynthetic process
CAL12_RS10795	COG0477	Major facilitator Superfamily
CAL12_RS10800	COG0583	DNA-binding transcription factor activity
CAL12_RS10805	COG4598	ABC transporter
CAL12_RS10810	COG0765	amino acid transport
CAL12_RS10815	COG0765	amino acid transport
CAL12_RS10825	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
CAL12_RS10835	COG0010	Belongs to the arginase family
CAL12_RS10880	COG2951	lytic endotransglycosylase activity
CAL12_RS10915	COG0590	tRNA wobble adenosine to inosine editing
CAL12_RS10920	COG1619	proteins homologs of microcin C7 resistance protein MccF
CAL12_RS10925	COG4651	solute:proton antiporter activity
CAL12_RS10925	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CAL12_RS10930	COG1024	Enoyl-CoA hydratase
CAL12_RS10935	COG0488	(ABC) transporter
CAL12_RS10950	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CAL12_RS10955	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CAL12_RS10975	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CAL12_RS10980	COG0667	Aldo Keto reductase
CAL12_RS10995	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
CAL12_RS11005	COG1595	DNA-templated transcription, initiation
CAL12_RS11010	COG4774	siderophore transport
CAL12_RS11020	COG1595	DNA-templated transcription, initiation
CAL12_RS11040	COG0318	PFAM AMP-dependent synthetase and ligase
CAL12_RS11045	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CAL12_RS11070	COG4774	siderophore transport
CAL12_RS11100	COG2091	lysine biosynthetic process via aminoadipic acid
CAL12_RS11105	COG2271	Major facilitator Superfamily
CAL12_RS11145	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CAL12_RS11150	COG1414	Transcriptional regulator
CAL12_RS11155	COG3181	Tripartite tricarboxylate transporter family receptor
CAL12_RS11170	COG0840	transmembrane signaling receptor activity
CAL12_RS11185	COG1349	DNA-binding transcription factor activity
CAL12_RS11200	COG2072	flavoprotein involved in K transport
CAL12_RS11205	COG1028	Short-chain dehydrogenase reductase Sdr
CAL12_RS11225	COG0402	S-adenosylhomocysteine deaminase activity
CAL12_RS11240	COG0765	amino acid transport
CAL12_RS11245	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CAL12_RS11270	COG0583	DNA-binding transcription factor activity
CAL12_RS11275	COG0436	Aminotransferase
CAL12_RS11455	COG1538	Outer membrane efflux protein
CAL12_RS11465	COG2274	protein secretion by the type I secretion system
CAL12_RS11470	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CAL12_RS11475	COG2197	response regulator
CAL12_RS11565	COG3706	GGDEF domain
CAL12_RS11580	COG0235	Class ii aldolase
CAL12_RS11600	COG1609	Transcriptional regulator
CAL12_RS11605	COG0583	DNA-binding transcription factor activity
CAL12_RS11610	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CAL12_RS11620	COG3181	Tripartite tricarboxylate transporter family receptor
CAL12_RS11630	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CAL12_RS11635	COG3181	Tripartite tricarboxylate transporter family receptor
CAL12_RS11650	COG3181	Tripartite tricarboxylate transporter family receptor
CAL12_RS11665	COG0789	Transcriptional regulator
CAL12_RS11675	COG0789	Transcriptional regulator
CAL12_RS11690	COG0678	peroxiredoxin activity
CAL12_RS11690	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CAL12_RS11720	COG0339	signal peptide processing
CAL12_RS11725	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CAL12_RS11730	COG4566	intracellular signal transduction
CAL12_RS11745	COG0508	dehydrogenase complex catalyzes the overall conversion of
CAL12_RS11750	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CAL12_RS11770	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
CAL12_RS11780	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CAL12_RS11815	COG1360	Flagellar Motor Protein
CAL12_RS11820	COG0745	RESPONSE REGULATOR receiver
CAL12_RS11830	COG0835	chemotaxis
CAL12_RS11835	COG0840	transmembrane signaling receptor activity
CAL12_RS11840	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CAL12_RS11845	COG2201	protein-glutamate methylesterase activity
CAL12_RS11850	COG0745	RESPONSE REGULATOR receiver
CAL12_RS11855	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
CAL12_RS11860	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CAL12_RS11890	COG1815	bacterial-type flagellum-dependent cell motility
CAL12_RS11895	COG1558	bacterial-type flagellum-dependent cell motility
CAL12_RS11910	COG4787	bacterial-type flagellum-dependent cell motility
CAL12_RS11935	COG1256	bacterial-type flagellum assembly
CAL12_RS11945	COG0840	transmembrane signaling receptor activity
CAL12_RS11990	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CAL12_RS11995	COG1580	Controls the rotational direction of flagella during chemotaxis
CAL12_RS12020	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CAL12_RS12030	COG1677	Flagellar hook-basal body complex protein FliE
CAL12_RS12035	COG5001	Diguanylate cyclase
CAL12_RS12035	COG3300	MHYT domain
CAL12_RS12045	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CAL12_RS12065	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CAL12_RS12070	COG1334	flagellar protein FlaG
CAL12_RS12075	COG0285	dihydrofolate synthase activity
CAL12_RS12095	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CAL12_RS12105	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CAL12_RS12110	COG0024	Methionine aminopeptidase
CAL12_RS12115	COG0052	Belongs to the universal ribosomal protein uS2 family
CAL12_RS12120	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CAL12_RS12125	COG0528	UMP kinase activity
CAL12_RS12130	COG0233	cytoplasmic translational termination
CAL12_RS12135	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CAL12_RS12140	COG0575	Belongs to the CDS family
CAL12_RS12145	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CAL12_RS12150	COG0750	zinc metalloprotease
CAL12_RS12155	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CAL12_RS12160	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
CAL12_RS12165	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CAL12_RS12170	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CAL12_RS12180	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CAL12_RS12185	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CAL12_RS12190	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CAL12_RS12205	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CAL12_RS12205	COG2169	Transcriptional regulator
CAL12_RS12210	COG0519	Catalyzes the synthesis of GMP from XMP
CAL12_RS12210	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CAL12_RS12225	COG3706	GGDEF domain
CAL12_RS12230	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CAL12_RS12235	COG2867	negative regulation of translational initiation
CAL12_RS12250	COG1024	Enoyl-CoA hydratase
CAL12_RS12250	COG1250	3-hydroxyacyl-CoA dehydrogenase
CAL12_RS12280	COG0411	ABC transporter
CAL12_RS12305	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
CAL12_RS12325	COG2814	Major facilitator Superfamily
CAL12_RS12335	COG2814	Major facilitator Superfamily
CAL12_RS12340	COG0697	spore germination
CAL12_RS12345	COG2363	Small membrane protein
CAL12_RS12355	COG0395	ABC-type sugar transport system, permease component
CAL12_RS12360	COG1116	anion transmembrane transporter activity
CAL12_RS12375	COG4974	Belongs to the 'phage' integrase family
CAL12_RS12385	COG0288	reversible hydration of carbon dioxide
CAL12_RS12390	COG1464	Belongs to the NlpA lipoprotein family
CAL12_RS12395	COG0628	permease
CAL12_RS12400	COG0735	belongs to the Fur family
CAL12_RS12405	COG0583	DNA-binding transcription factor activity
CAL12_RS12415	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CAL12_RS12440	COG2205	protein histidine kinase activity
CAL12_RS12440	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CAL12_RS12465	COG2268	Band 7 protein
CAL12_RS12470	COG5564	TIM-barrel signal transduction protein
CAL12_RS12475	COG5441	Belongs to the UPF0261 family
CAL12_RS12500	COG0402	S-adenosylhomocysteine deaminase activity
CAL12_RS12505	COG0596	Alpha beta hydrolase
CAL12_RS12515	COG1028	Short-chain dehydrogenase reductase Sdr
CAL12_RS12545	COG3181	Tripartite tricarboxylate transporter family receptor
CAL12_RS12550	COG0473	3-isopropylmalate dehydrogenase activity
CAL12_RS12560	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CAL12_RS12580	COG1304	FMN binding
CAL12_RS12585	COG0583	DNA-binding transcription factor activity
CAL12_RS12595	COG3181	Tripartite tricarboxylate transporter family receptor
CAL12_RS12620	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CAL12_RS12620	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CAL12_RS12655	COG1216	Glycosyl transferase, family 2
CAL12_RS12670	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CAL12_RS12675	COG0066	3-isopropylmalate dehydratase activity
CAL12_RS12695	COG0583	DNA-binding transcription factor activity
CAL12_RS12720	COG0432	Pfam Uncharacterised protein family UPF0047
CAL12_RS12730	COG3976	FMN-binding domain protein
CAL12_RS12730	COG1053	succinate dehydrogenase
CAL12_RS12770	COG0583	DNA-binding transcription factor activity
CAL12_RS12780	COG0318	PFAM AMP-dependent synthetase and ligase
CAL12_RS12785	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CAL12_RS12790	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CAL12_RS12795	COG1024	Enoyl-CoA hydratase
CAL12_RS12820	COG3473	Maleate cis-trans isomerase
CAL12_RS12825	COG0596	Alpha beta hydrolase
CAL12_RS12830	COG2309	aminopeptidase activity
CAL12_RS12835	COG1335	isochorismatase
CAL12_RS12860	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CAL12_RS12890	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CAL12_RS12905	COG0243	molybdopterin cofactor binding
CAL12_RS12910	COG0437	4 iron, 4 sulfur cluster binding
CAL12_RS12915	COG3302	dmso reductase anchor subunit
CAL12_RS12925	COG2909	trisaccharide binding
CAL12_RS12935	COG0165	Argininosuccinate lyase
CAL12_RS12950	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CAL12_RS12955	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
CAL12_RS12970	COG0318	PFAM AMP-dependent synthetase and ligase
CAL12_RS12985	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CAL12_RS12990	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CAL12_RS13035	COG1309	transcriptional regulator
CAL12_RS13045	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CAL12_RS13060	COG0784	Response regulator, receiver
CAL12_RS13065	COG4251	negative regulation of phosphorylation
CAL12_RS13100	COG2188	Transcriptional regulator
CAL12_RS13115	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CAL12_RS13120	COG2159	amidohydrolase
CAL12_RS13125	COG3181	Tripartite tricarboxylate transporter family receptor
CAL12_RS13130	COG3181	Tripartite tricarboxylate transporter family receptor
CAL12_RS13150	COG1360	Flagellar Motor Protein
CAL12_RS13195	COG0306	phosphate transporter
CAL12_RS13220	COG0583	DNA-binding transcription factor activity
CAL12_RS13235	COG1595	DNA-templated transcription, initiation
CAL12_RS13255	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CAL12_RS13260	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CAL12_RS13280	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CAL12_RS13285	COG0583	DNA-binding transcription factor activity
CAL12_RS13295	COG1902	pentaerythritol trinitrate reductase activity
CAL12_RS13300	COG1012	belongs to the aldehyde dehydrogenase family
CAL12_RS13305	COG0583	DNA-binding transcription factor activity
CAL12_RS13315	COG3976	FMN-binding domain protein
CAL12_RS13315	COG1053	succinate dehydrogenase
CAL12_RS13315	COG0431	NADPH-dependent FMN reductase
CAL12_RS13325	COG2079	MmgE PrpD family protein
CAL12_RS13360	COG1132	(ABC) transporter
CAL12_RS13375	COG2200	EAL domain
CAL12_RS13385	COG3386	PFAM SMP-30 Gluconolaconase
CAL12_RS13400	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CAL12_RS13405	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CAL12_RS13415	COG3181	Tripartite tricarboxylate transporter family receptor
CAL12_RS13435	COG0747	negative chemotaxis
CAL12_RS13445	COG0601	transmembrane transport
CAL12_RS13455	COG0444	Belongs to the ABC transporter superfamily
CAL12_RS13460	COG4608	Belongs to the ABC transporter superfamily
CAL12_RS13475	COG3008	intermembrane lipid transfer
CAL12_RS13475	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CAL12_RS13480	COG0628	permease
CAL12_RS13485	COG4191	Histidine kinase
CAL12_RS13485	COG0784	Response regulator, receiver
CAL12_RS13490	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
CAL12_RS13505	COG0640	Transcriptional regulator
CAL12_RS13510	COG1902	pentaerythritol trinitrate reductase activity
CAL12_RS13515	COG2814	Major facilitator Superfamily
CAL12_RS13525	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
CAL12_RS13535	COG4106	trans-aconitate 2-methyltransferase activity
CAL12_RS13555	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CAL12_RS13570	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CAL12_RS13610	COG0066	3-isopropylmalate dehydratase activity
CAL12_RS13615	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CAL12_RS13620	COG1053	succinate dehydrogenase
CAL12_RS13630	COG0583	DNA-binding transcription factor activity
CAL12_RS13650	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CAL12_RS13655	COG3181	Tripartite tricarboxylate transporter family receptor
CAL12_RS13660	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CAL12_RS13670	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CAL12_RS13690	COG3119	arylsulfatase activity
CAL12_RS13710	COG0840	transmembrane signaling receptor activity
CAL12_RS13720	COG1301	dicarboxylic acid transport
CAL12_RS13725	COG3181	Tripartite tricarboxylate transporter family receptor
CAL12_RS13730	COG0583	DNA-binding transcription factor activity
CAL12_RS13740	COG2188	Transcriptional regulator
CAL12_RS13750	COG4521	taurine ABC transporter
CAL12_RS13755	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CAL12_RS13760	COG1116	anion transmembrane transporter activity
CAL12_RS13765	COG3119	arylsulfatase activity
CAL12_RS13770	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CAL12_RS13775	COG0659	secondary active sulfate transmembrane transporter activity
CAL12_RS13780	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CAL12_RS13785	COG1492	cobalamin metabolic process
CAL12_RS13790	COG3842	ATPase activity
CAL12_RS13795	COG1176	ABC-type spermidine putrescine transport system, permease component I
CAL12_RS13800	COG1177	transmembrane transport
CAL12_RS13820	COG2207	Transcriptional regulator
CAL12_RS13835	COG1063	alcohol dehydrogenase
CAL12_RS13845	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CAL12_RS13850	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
CAL12_RS13875	COG0488	(ABC) transporter
CAL12_RS13880	COG0542	response to heat
CAL12_RS13885	COG3300	MHYT domain
CAL12_RS13885	COG5001	Diguanylate cyclase
CAL12_RS13900	COG3048	D-serine ammonia-lyase activity
CAL12_RS13910	COG0154	amidase activity
CAL12_RS13920	COG2814	Major facilitator Superfamily
CAL12_RS13935	COG1028	Short-chain dehydrogenase reductase Sdr
CAL12_RS13945	COG0318	PFAM AMP-dependent synthetase and ligase
CAL12_RS13950	COG3181	Tripartite tricarboxylate transporter family receptor
CAL12_RS13965	COG2175	clavaminate synthase activity
CAL12_RS13980	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CAL12_RS14035	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CAL12_RS14040	COG0318	PFAM AMP-dependent synthetase and ligase
CAL12_RS14045	COG1024	Enoyl-CoA hydratase
CAL12_RS14070	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CAL12_RS14100	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
CAL12_RS14105	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CAL12_RS14120	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CAL12_RS14140	COG0589	response to stress
CAL12_RS14145	COG0583	DNA-binding transcription factor activity
CAL12_RS14150	COG2515	1-aminocyclopropane-1-carboxylate deaminase
CAL12_RS14155	COG0589	response to stress
CAL12_RS14165	COG0625	glutathione transferase activity
CAL12_RS14170	COG1017	nitric oxide dioxygenase activity
CAL12_RS14170	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CAL12_RS14180	COG0583	DNA-binding transcription factor activity
CAL12_RS14185	COG1960	acyl-CoA dehydrogenase activity
CAL12_RS14190	COG0583	DNA-binding transcription factor activity
CAL12_RS14195	COG0778	Nitroreductase
CAL12_RS14210	COG4772	TonB-dependent receptor
CAL12_RS14215	COG3712	iron ion homeostasis
CAL12_RS14230	COG4221	oxidoreductase activity
CAL12_RS14240	COG1022	Amp-dependent synthetase and ligase
CAL12_RS14255	COG0642	Histidine kinase
CAL12_RS14275	COG3181	Tripartite tricarboxylate transporter family receptor
CAL12_RS14280	COG0583	DNA-binding transcription factor activity
CAL12_RS14300	COG0300	oxidoreductase activity
CAL12_RS14310	COG0583	DNA-binding transcription factor activity
CAL12_RS14330	COG3278	Belongs to the heme-copper respiratory oxidase family
CAL12_RS14345	COG2010	Cytochrome c
CAL12_RS14350	COG0348	domain, Protein
CAL12_RS14370	COG0784	Response regulator, receiver
CAL12_RS14375	COG4191	Histidine kinase
CAL12_RS14385	COG0589	response to stress
CAL12_RS14400	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CAL12_RS14410	COG0693	protein deglycase activity
CAL12_RS14420	COG2072	flavoprotein involved in K transport
CAL12_RS14425	COG3842	ATPase activity
CAL12_RS14445	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CAL12_RS14450	COG1177	transmembrane transport
CAL12_RS14455	COG1176	ABC-type spermidine putrescine transport system, permease component I
CAL12_RS14465	COG1126	abc transporter atp-binding protein
CAL12_RS14480	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CAL12_RS14505	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CAL12_RS14520	COG0583	DNA-binding transcription factor activity
CAL12_RS14545	COG3181	Tripartite tricarboxylate transporter family receptor
CAL12_RS14585	COG0583	DNA-binding transcription factor activity
CAL12_RS14600	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
CAL12_RS14605	COG2721	sulfolactate sulfo-lyase activity
CAL12_RS14615	COG0583	DNA-binding transcription factor activity
CAL12_RS14620	COG3181	Tripartite tricarboxylate transporter family receptor
CAL12_RS14650	COG0154	amidase activity
CAL12_RS14685	COG0583	DNA-binding transcription factor activity
CAL12_RS14695	COG0784	Response regulator, receiver
CAL12_RS14695	COG4191	Histidine kinase
CAL12_RS14705	COG0179	Fumarylacetoacetate (FAA) hydrolase
CAL12_RS14710	COG1802	Transcriptional regulator
CAL12_RS14735	COG3384	dioxygenase
CAL12_RS14790	COG1802	Transcriptional regulator
CAL12_RS14800	COG4948	Mandelate Racemase Muconate Lactonizing
CAL12_RS14815	COG4948	Mandelate Racemase Muconate Lactonizing
CAL12_RS14830	COG0277	FAD linked oxidase domain protein
CAL12_RS14860	COG1024	Enoyl-CoA hydratase
CAL12_RS14865	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CAL12_RS14890	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CAL12_RS14930	COG0437	4 iron, 4 sulfur cluster binding
CAL12_RS14970	COG1366	Belongs to the anti-sigma-factor antagonist family
CAL12_RS14975	COG2172	sigma factor antagonist activity
CAL12_RS14980	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CAL12_RS14990	COG2208	phosphoserine phosphatase activity
CAL12_RS14990	COG2770	Histidine kinase
CAL12_RS15020	COG4948	Mandelate Racemase Muconate Lactonizing
CAL12_RS15050	COG0747	negative chemotaxis
CAL12_RS15075	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CAL12_RS15090	COG0444	Belongs to the ABC transporter superfamily
CAL12_RS15115	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CAL12_RS15120	COG3181	Tripartite tricarboxylate transporter family receptor
CAL12_RS15135	COG3842	ATPase activity
CAL12_RS15145	COG1177	transmembrane transport
CAL12_RS15150	COG3938	Belongs to the proline racemase family
CAL12_RS15160	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CAL12_RS15180	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CAL12_RS15190	COG2070	2-Nitropropane dioxygenase
CAL12_RS15210	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CAL12_RS15235	COG0583	DNA-binding transcription factor activity
CAL12_RS15240	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CAL12_RS15260	COG3181	Tripartite tricarboxylate transporter family receptor
CAL12_RS15265	COG4948	Mandelate Racemase Muconate Lactonizing
CAL12_RS15275	COG1840	ABC-type Fe3 transport system, periplasmic component
CAL12_RS15280	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
CAL12_RS15285	COG3842	ATPase activity
CAL12_RS15290	COG1741	Belongs to the pirin family
CAL12_RS15295	COG1741	Belongs to the pirin family
CAL12_RS15300	COG0583	DNA-binding transcription factor activity
CAL12_RS15320	COG0174	glutamine synthetase
CAL12_RS15325	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CAL12_RS15330	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CAL12_RS15335	COG2199	diguanylate cyclase activity
CAL12_RS15335	COG2200	EAL domain
CAL12_RS15340	COG0840	transmembrane signaling receptor activity
CAL12_RS15345	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CAL12_RS15350	COG1561	YicC-like family, N-terminal region
CAL12_RS15355	COG2860	membrane
CAL12_RS15380	COG2304	oxidoreductase activity
CAL12_RS15390	COG0714	Associated with various cellular activities
CAL12_RS15395	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CAL12_RS15400	COG2304	oxidoreductase activity
CAL12_RS15405	COG3781	membrane
CAL12_RS15415	COG4771	TonB-dependent receptor
CAL12_RS15420	COG0791	NLP P60 protein
CAL12_RS15425	COG1028	Short-chain dehydrogenase reductase Sdr
CAL12_RS15430	COG0194	GDP metabolic process
CAL12_RS15435	COG1758	RNA polymerase activity
CAL12_RS15440	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CAL12_RS15450	COG0583	DNA-binding transcription factor activity
CAL12_RS15465	COG1126	abc transporter atp-binding protein
CAL12_RS15470	COG0765	amino acid transport
CAL12_RS15475	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CAL12_RS15495	COG0084	hydrolase, TatD family'
CAL12_RS15505	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CAL12_RS15510	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CAL12_RS15525	COG1653	transport
CAL12_RS15530	COG1175	transmembrane transport
CAL12_RS15535	COG0395	ABC-type sugar transport system, permease component
CAL12_RS15540	COG3842	ATPase activity
CAL12_RS15580	COG1393	Belongs to the ArsC family
CAL12_RS15585	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CAL12_RS15595	COG0386	Belongs to the glutathione peroxidase family
CAL12_RS15600	COG0154	amidase activity
CAL12_RS15625	COG1012	belongs to the aldehyde dehydrogenase family
CAL12_RS15630	COG0657	acetylesterase activity
CAL12_RS15665	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
CAL12_RS15670	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CAL12_RS15680	COG1309	transcriptional regulator
CAL12_RS15690	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CAL12_RS15720	COG4336	lyase activity
CAL12_RS15740	COG0277	FAD linked oxidase domain protein
CAL12_RS15745	COG4181	ATPase activity
CAL12_RS15755	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CAL12_RS15760	COG0584	glycerophosphoryl diester phosphodiesterase
CAL12_RS15765	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
CAL12_RS15780	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CAL12_RS15795	COG1522	sequence-specific DNA binding
CAL12_RS15800	COG0028	Belongs to the TPP enzyme family
CAL12_RS15815	COG0163	prenyltransferase activity
CAL12_RS15850	COG1012	belongs to the aldehyde dehydrogenase family
CAL12_RS15860	COG4948	Mandelate Racemase Muconate Lactonizing
CAL12_RS15865	COG0583	DNA-binding transcription factor activity
CAL12_RS15870	COG1187	pseudouridine synthase activity
CAL12_RS15875	COG3161	chorismate lyase activity
CAL12_RS15890	COG1733	regulation of RNA biosynthetic process
CAL12_RS15905	COG4172	Belongs to the ABC transporter superfamily
CAL12_RS15910	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CAL12_RS15915	COG0601	transmembrane transport
CAL12_RS15920	COG0747	negative chemotaxis
CAL12_RS15935	COG2154	pterin-4-alpha-carbinolamine dehydratase
CAL12_RS15950	COG0165	Argininosuccinate lyase
CAL12_RS15955	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CAL12_RS15980	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CAL12_RS15985	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CAL12_RS15990	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CAL12_RS15995	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CAL12_RS16000	COG2252	PERMEase
CAL12_RS16005	COG0602	queuosine metabolic process
CAL12_RS16010	COG0720	synthase
CAL12_RS16015	COG3655	Transcriptional regulator
CAL12_RS16030	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CAL12_RS16045	COG3181	Tripartite tricarboxylate transporter family receptor
CAL12_RS16050	COG2814	Major facilitator Superfamily
CAL12_RS16055	COG3181	Tripartite tricarboxylate transporter family receptor
CAL12_RS16060	COG1228	amidohydrolase
CAL12_RS16070	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CAL12_RS16090	COG0300	oxidoreductase activity
CAL12_RS16120	COG0583	DNA-binding transcription factor activity
CAL12_RS16130	COG1793	dna ligase
CAL12_RS16140	COG0297	glycogen (starch) synthase activity
CAL12_RS16145	COG0366	Alpha amylase catalytic
CAL12_RS16155	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CAL12_RS16165	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CAL12_RS16170	COG1640	4-alpha-glucanotransferase
CAL12_RS16185	COG1289	transmembrane transporter activity
CAL12_RS16195	COG1566	PFAM secretion protein HlyD family protein
CAL12_RS16200	COG1538	Outer membrane efflux protein
CAL12_RS16205	COG0400	carboxylic ester hydrolase activity
CAL12_RS16230	COG3181	Tripartite tricarboxylate transporter family receptor
CAL12_RS16240	COG3181	Tripartite tricarboxylate transporter family receptor
CAL12_RS16255	COG1136	(ABC) transporter
CAL12_RS16265	COG1960	acyl-CoA dehydrogenase activity
CAL12_RS16270	COG1960	acyl-CoA dehydrogenase activity
CAL12_RS16275	COG0318	PFAM AMP-dependent synthetase and ligase
CAL12_RS16290	COG1024	Enoyl-CoA hydratase
CAL12_RS16295	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CAL12_RS16315	COG1250	3-hydroxyacyl-CoA dehydrogenase
CAL12_RS16320	COG4948	Mandelate Racemase Muconate Lactonizing
CAL12_RS16340	COG0395	ABC-type sugar transport system, permease component
CAL12_RS16350	COG3842	ATPase activity
CAL12_RS16355	COG3842	ATPase activity
CAL12_RS16365	COG0477	Major facilitator Superfamily
CAL12_RS16370	COG0519	Catalyzes the synthesis of GMP from XMP
CAL12_RS16385	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CAL12_RS16390	COG2807	transmembrane transport
CAL12_RS16395	COG2207	Transcriptional regulator
CAL12_RS16415	COG0583	DNA-binding transcription factor activity
CAL12_RS16420	COG0583	DNA-binding transcription factor activity
CAL12_RS16425	COG0667	Aldo Keto reductase
CAL12_RS16430	COG0583	DNA-binding transcription factor activity
CAL12_RS16440	COG1028	Short-chain dehydrogenase reductase Sdr
CAL12_RS16450	COG0251	oxidation-reduction process
CAL12_RS16455	COG1028	Short-chain dehydrogenase reductase Sdr
CAL12_RS16465	COG0300	oxidoreductase activity
CAL12_RS16480	COG2084	Dehydrogenase
CAL12_RS16485	COG1309	transcriptional regulator
CAL12_RS16495	COG1309	transcriptional regulator
CAL12_RS16515	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CAL12_RS16520	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
CAL12_RS16550	COG0583	DNA-binding transcription factor activity
CAL12_RS16560	COG0436	Aminotransferase
CAL12_RS16570	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
CAL12_RS16595	COG1024	Enoyl-CoA hydratase
CAL12_RS16605	COG3181	Tripartite tricarboxylate transporter family receptor
CAL12_RS16630	COG0583	DNA-binding transcription factor activity
CAL12_RS16635	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
CAL12_RS16655	COG1228	amidohydrolase
CAL12_RS16665	COG0028	Belongs to the TPP enzyme family
CAL12_RS16675	COG1309	transcriptional regulator
CAL12_RS16680	COG0477	Major facilitator Superfamily
CAL12_RS16695	COG0583	DNA-binding transcription factor activity
CAL12_RS16710	COG0667	Aldo Keto reductase
CAL12_RS16735	COG2755	lipolytic protein G-D-S-L family
CAL12_RS16735	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CAL12_RS16740	COG2814	Major facilitator Superfamily
CAL12_RS16745	COG0583	DNA-binding transcription factor activity
CAL12_RS16755	COG1309	transcriptional regulator
CAL12_RS16765	COG0840	transmembrane signaling receptor activity
CAL12_RS16785	COG1846	Transcriptional regulator
CAL12_RS16790	COG2814	Major facilitator Superfamily
CAL12_RS16800	COG1309	transcriptional regulator
CAL12_RS16810	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CAL12_RS16820	COG1309	transcriptional regulator
CAL12_RS16840	COG1733	regulation of RNA biosynthetic process
CAL12_RS16900	COG0583	DNA-binding transcription factor activity
CAL12_RS16915	COG1028	Short-chain dehydrogenase reductase Sdr
CAL12_RS16920	COG0583	DNA-binding transcription factor activity
CAL12_RS16935	COG1733	regulation of RNA biosynthetic process
CAL12_RS16940	COG1028	Short-chain dehydrogenase reductase Sdr
CAL12_RS16945	COG1309	transcriptional regulator
CAL12_RS16970	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CAL12_RS16990	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CAL12_RS17005	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CAL12_RS17015	COG0583	DNA-binding transcription factor activity
CAL12_RS17035	COG0519	Catalyzes the synthesis of GMP from XMP
CAL12_RS17035	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CAL12_RS17045	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CAL12_RS17065	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CAL12_RS17065	COG0047	phosphoribosylformylglycinamidine synthase activity
CAL12_RS17075	COG0613	PHP domain protein
CAL12_RS17095	COG0084	hydrolase, TatD family'
CAL12_RS17100	COG1136	(ABC) transporter
CAL12_RS17115	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CAL12_RS17120	COG2271	Major facilitator Superfamily
CAL12_RS17130	COG1028	Short-chain dehydrogenase reductase Sdr
CAL12_RS17135	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CAL12_RS17140	COG1803	Methylglyoxal synthase
CAL12_RS17150	COG0633	Ferredoxin
CAL12_RS17155	COG0443	Heat shock 70 kDa protein
CAL12_RS17160	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CAL12_RS17170	COG0822	iron-sulfur transferase activity
CAL12_RS17175	COG1104	cysteine desulfurase activity
CAL12_RS17185	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CAL12_RS17190	COG0556	nucleotide-excision repair
CAL12_RS17200	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CAL12_RS17205	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CAL12_RS17215	COG0740	serine-type endopeptidase activity
CAL12_RS17220	COG0544	peptidyl-prolyl cis-trans isomerase activity
CAL12_RS17230	COG1278	Cold shock
CAL12_RS17245	COG2171	N-acyltransferase activity
CAL12_RS17255	COG2890	protein-(glutamine-N5) methyltransferase activity
CAL12_RS17260	COG0488	(ABC) transporter
CAL12_RS17265	COG0210	DNA helicase
CAL12_RS17280	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CAL12_RS17280	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CAL12_RS17285	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CAL12_RS17290	COG0196	riboflavin kinase activity
CAL12_RS17295	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CAL12_RS17305	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CAL12_RS17310	COG1988	membrane-bound metal-dependent
CAL12_RS17325	COG0756	dUTP diphosphatase activity
CAL12_RS17330	COG1902	pentaerythritol trinitrate reductase activity
CAL12_RS17335	COG1914	H( )-stimulated, divalent metal cation uptake system
CAL12_RS17365	COG0506	proline dehydrogenase activity
CAL12_RS17365	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CAL12_RS17365	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CAL12_RS17375	COG3008	intermembrane lipid transfer
CAL12_RS17380	COG2995	paraquat-inducible protein a
CAL12_RS17385	COG0542	response to heat
CAL12_RS17390	COG4953	penicillin-binding protein 1C
CAL12_RS17400	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CAL12_RS17405	COG1278	Cold shock
CAL12_RS17415	COG0183	Belongs to the thiolase family
CAL12_RS17425	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CAL12_RS17430	COG1570	exodeoxyribonuclease VII activity
CAL12_RS17435	COG0811	peptide transport
CAL12_RS17450	COG2835	tetraacyldisaccharide 4'-kinase activity
CAL12_RS17460	COG0563	adenylate kinase activity
CAL12_RS17470	COG0728	peptidoglycan biosynthetic process
CAL12_RS17480	COG0268	Binds directly to 16S ribosomal RNA
CAL12_RS17485	COG3836	Belongs to the HpcH HpaI aldolase family
CAL12_RS17495	COG2186	Transcriptional regulator
CAL12_RS17510	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CAL12_RS17520	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CAL12_RS17535	COG3158	transport of potassium into the cell
CAL12_RS17540	COG0642	Histidine kinase
CAL12_RS17565	COG1454	alcohol dehydrogenase
CAL12_RS17575	COG0776	regulation of translation
CAL12_RS17580	COG3128	pkhd-type hydroxylase
CAL12_RS17585	COG0626	cystathionine gamma-synthase activity
CAL12_RS17590	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CAL12_RS17595	COG0557	exoribonuclease II activity
CAL12_RS17615	COG0679	Auxin Efflux Carrier
CAL12_RS17620	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CAL12_RS17625	COG0069	glutamate synthase activity
CAL12_RS17635	COG2204	response regulator
CAL12_RS17640	COG2204	response regulator
CAL12_RS17650	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CAL12_RS17665	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CAL12_RS17685	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
CAL12_RS17690	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CAL12_RS17705	COG1278	Cold shock
CAL12_RS17730	COG0625	glutathione transferase activity
CAL12_RS17735	COG0730	response to heat
CAL12_RS17760	COG0247	lactate metabolic process
CAL12_RS17765	COG0277	FAD linked oxidase domain protein
CAL12_RS17770	COG0277	FAD linked oxidase domain protein
CAL12_RS17775	COG0277	FAD linked oxidase domain protein
CAL12_RS17780	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CAL12_RS17785	COG0312	modulator of DNA gyrase
CAL12_RS17805	COG0308	aminopeptidase N
CAL12_RS17810	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
CAL12_RS17830	COG1846	Transcriptional regulator
CAL12_RS17840	COG1566	PFAM secretion protein HlyD family protein
CAL12_RS17845	COG2814	Major facilitator Superfamily
CAL12_RS17855	COG0473	3-isopropylmalate dehydrogenase activity
CAL12_RS17860	COG0433	COG0433 Predicted ATPase
CAL12_RS17865	COG0217	transcriptional regulatory protein
CAL12_RS17870	COG0151	Belongs to the GarS family
CAL12_RS17880	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CAL12_RS17885	COG0799	negative regulation of ribosome biogenesis
CAL12_RS17890	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CAL12_RS17900	COG1301	dicarboxylic acid transport
CAL12_RS17945	COG1132	(ABC) transporter
CAL12_RS17965	COG0726	polysaccharide deacetylase
CAL12_RS17980	COG0726	polysaccharide deacetylase
CAL12_RS17985	COG0438	transferase activity, transferring glycosyl groups
CAL12_RS18010	COG1028	Short-chain dehydrogenase reductase Sdr
CAL12_RS18015	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CAL12_RS18015	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CAL12_RS18020	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
CAL12_RS18025	COG0704	Plays a role in the regulation of phosphate uptake
CAL12_RS18030	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CAL12_RS18050	COG1393	Belongs to the ArsC family
CAL12_RS18055	COG1177	transmembrane transport
CAL12_RS18060	COG1176	ABC-type spermidine putrescine transport system, permease component I
CAL12_RS18065	COG3842	ATPase activity
CAL12_RS18070	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CAL12_RS18075	COG3642	lipopolysaccharide core region biosynthetic process
CAL12_RS18085	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
CAL12_RS18115	COG0583	DNA-binding transcription factor activity
CAL12_RS18120	COG3181	Tripartite tricarboxylate transporter family receptor
CAL12_RS18125	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CAL12_RS18145	COG0583	DNA-binding transcription factor activity
CAL12_RS18155	COG1960	acyl-CoA dehydrogenase activity
CAL12_RS18160	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CAL12_RS18165	COG1024	Enoyl-CoA hydratase
CAL12_RS18180	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CAL12_RS18185	COG1562	ergosterol biosynthetic process
CAL12_RS18200	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CAL12_RS18205	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CAL12_RS18230	COG0436	Aminotransferase
CAL12_RS18235	COG3737	Protein of unknown function (DUF498/DUF598)
CAL12_RS18240	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CAL12_RS18245	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CAL12_RS18250	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CAL12_RS18265	COG0305	Participates in initiation and elongation during chromosome replication
CAL12_RS18280	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CAL12_RS18285	COG2965	DNA replication, synthesis of RNA primer
CAL12_RS18290	COG0360	Binds together with S18 to 16S ribosomal RNA
CAL12_RS18295	COG1469	GTP cyclohydrolase I activity
CAL12_RS18305	COG0142	geranyltranstransferase activity
CAL12_RS18310	COG1722	exodeoxyribonuclease VII activity
CAL12_RS18320	COG0640	Transcriptional regulator
CAL12_RS18340	COG0501	Belongs to the peptidase M48B family
CAL12_RS18345	COG1283	sodium-dependent phosphate transmembrane transporter activity
CAL12_RS18355	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CAL12_RS18355	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CAL12_RS18370	COG0831	urea catabolic process
CAL12_RS18380	COG0832	Belongs to the urease beta subunit family
CAL12_RS18390	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
CAL12_RS18395	COG0830	nickel cation binding
CAL12_RS18400	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CAL12_RS18410	COG3181	Tripartite tricarboxylate transporter family receptor
CAL12_RS18415	COG1217	gtp-binding protein TYPA
CAL12_RS18420	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CAL12_RS18425	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CAL12_RS18430	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CAL12_RS18435	COG0195	Participates in both transcription termination and antitermination
CAL12_RS18435	COG2251	uridine kinase activity
CAL12_RS18440	COG0779	Required for maturation of 30S ribosomal subunits
CAL12_RS18445	COG1187	pseudouridine synthase activity
CAL12_RS18450	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CAL12_RS18460	COG0523	cobalamin synthesis protein
CAL12_RS18465	COG0251	oxidation-reduction process
CAL12_RS18475	COG1116	anion transmembrane transporter activity
CAL12_RS18480	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CAL12_RS18485	COG1028	Short-chain dehydrogenase reductase Sdr
CAL12_RS18490	COG0179	Fumarylacetoacetate (FAA) hydrolase
CAL12_RS18500	COG3386	PFAM SMP-30 Gluconolaconase
CAL12_RS18505	COG0583	DNA-binding transcription factor activity
CAL12_RS18515	COG2814	Major facilitator Superfamily
CAL12_RS18550	COG2323	membrane
CAL12_RS18555	COG1546	Belongs to the CinA family
CAL12_RS18555	COG1058	Belongs to the CinA family
CAL12_RS18590	COG2188	Transcriptional regulator
CAL12_RS18595	COG2084	Dehydrogenase
CAL12_RS18605	COG2721	sulfolactate sulfo-lyase activity
CAL12_RS18610	COG0625	glutathione transferase activity
CAL12_RS18615	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CAL12_RS18625	COG2003	Belongs to the UPF0758 family
CAL12_RS18630	COG0254	rRNA binding
CAL12_RS18640	COG0534	Mate efflux family protein
CAL12_RS18650	COG2050	protein possibly involved in aromatic compounds catabolism
CAL12_RS18655	COG1024	Enoyl-CoA hydratase
CAL12_RS18660	COG1012	belongs to the aldehyde dehydrogenase family
CAL12_RS18665	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CAL12_RS18670	COG2151	metal-sulfur cluster biosynthetic enzyme
CAL12_RS18675	COG3396	Phenylacetate-CoA oxygenase
CAL12_RS18680	COG3460	Phenylacetate-CoA oxygenase
CAL12_RS18685	COG3396	Phenylacetate-CoA oxygenase
CAL12_RS18695	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
CAL12_RS18700	COG0501	Belongs to the peptidase M48B family
CAL12_RS18705	COG1162	GTPase activity
CAL12_RS18715	COG0335	large ribosomal subunit rRNA binding
CAL12_RS18740	COG0175	sulfate reduction
CAL12_RS18745	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CAL12_RS18750	COG4208	sulfate ABC transporter
CAL12_RS18760	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
CAL12_RS18765	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CAL12_RS18790	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
CAL12_RS18810	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CAL12_RS18815	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CAL12_RS18820	COG3618	amidohydrolase
CAL12_RS18830	COG0583	DNA-binding transcription factor activity
CAL12_RS18855	COG0450	alkyl hydroperoxide reductase
CAL12_RS18860	COG1960	acyl-CoA dehydrogenase activity
CAL12_RS18875	COG0123	including yeast histone deacetylase and acetoin utilization protein
CAL12_RS18880	COG2951	lytic endotransglycosylase activity
CAL12_RS18890	COG1596	polysaccharide export
CAL12_RS18890	COG1555	photosystem II stabilization
CAL12_RS18895	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CAL12_RS18900	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CAL12_RS18905	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
CAL12_RS18925	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CAL12_RS18930	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CAL12_RS18940	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CAL12_RS18950	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CAL12_RS18965	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CAL12_RS18970	COG0546	phosphoglycolate phosphatase activity
CAL12_RS18990	COG2207	Transcriptional regulator
CAL12_RS18995	COG0300	oxidoreductase activity
CAL12_RS19000	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CAL12_RS19005	COG2318	DinB family
CAL12_RS19010	COG2721	sulfolactate sulfo-lyase activity
CAL12_RS19015	COG2721	sulfolactate sulfo-lyase activity
CAL12_RS19025	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CAL12_RS19030	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
CAL12_RS19040	COG2833	Protein of unknown function (DUF455)
CAL12_RS19050	COG0840	transmembrane signaling receptor activity
CAL12_RS19075	COG2201	protein-glutamate methylesterase activity
CAL12_RS19080	COG2203	Gaf domain
CAL12_RS19080	COG3706	GGDEF domain
CAL12_RS19080	COG4251	negative regulation of phosphorylation
CAL12_RS19080	COG5001	Diguanylate cyclase
CAL12_RS19085	COG1802	Transcriptional regulator
CAL12_RS19090	COG0477	Major facilitator Superfamily
CAL12_RS19095	COG4948	Mandelate Racemase Muconate Lactonizing
CAL12_RS19100	COG0246	Mannitol dehydrogenase
CAL12_RS19110	COG1132	(ABC) transporter
CAL12_RS19115	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CAL12_RS19115	COG1181	Belongs to the D-alanine--D-alanine ligase family
CAL12_RS19120	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CAL12_RS19120	COG0189	ligase activity
CAL12_RS19130	COG2823	Periplasmic or secreted lipoprotein
CAL12_RS19145	COG0672	)-iron permease
CAL12_RS19160	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
CAL12_RS19165	COG1028	Short-chain dehydrogenase reductase Sdr
CAL12_RS19170	COG3243	poly(R)-hydroxyalkanoic acid synthase
CAL12_RS19180	COG0564	pseudouridine synthase activity
CAL12_RS19190	COG1199	ATP-dependent helicase activity
CAL12_RS19195	COG2183	response to ionizing radiation
CAL12_RS19210	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
CAL12_RS19215	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CAL12_RS19220	COG0508	dehydrogenase complex catalyzes the overall conversion of
CAL12_RS19225	COG0567	Dehydrogenase, E1 component
CAL12_RS19230	COG0281	malic enzyme
CAL12_RS19230	COG0280	phosphate acetyltransferase
CAL12_RS19245	COG0372	Belongs to the citrate synthase family
CAL12_RS19250	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
CAL12_RS19255	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CAL12_RS19260	COG1053	succinate dehydrogenase
CAL12_RS19265	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
CAL12_RS19270	COG2009	succinate dehydrogenase
CAL12_RS19275	COG2188	Transcriptional regulator
CAL12_RS19290	COG0039	L-malate dehydrogenase activity
CAL12_RS19300	COG2079	MmgE PrpD family protein
CAL12_RS19310	COG0625	glutathione transferase activity
CAL12_RS19315	COG0625	glutathione transferase activity
CAL12_RS19325	COG0477	Major facilitator Superfamily
CAL12_RS19335	COG3012	SEC-C Motif Domain Protein
CAL12_RS19375	COG0583	DNA-binding transcription factor activity
CAL12_RS19390	COG1196	nuclear chromosome segregation
CAL12_RS19390	COG3264	Mechanosensitive ion channel
CAL12_RS19405	COG2130	NADP-dependent
CAL12_RS19425	COG3383	formate dehydrogenase (NAD+) activity
CAL12_RS19425	COG0243	molybdopterin cofactor binding
CAL12_RS19430	COG0243	molybdopterin cofactor binding
CAL12_RS19430	COG3383	formate dehydrogenase (NAD+) activity
CAL12_RS19435	COG0437	4 iron, 4 sulfur cluster binding
CAL12_RS19440	COG2864	formate dehydrogenase
CAL12_RS19455	COG3276	selenocysteine insertion sequence binding
CAL12_RS19495	COG4126	flavin adenine dinucleotide binding
CAL12_RS19525	COG1268	BioY protein
CAL12_RS19530	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CAL12_RS19535	COG1122	ATPase activity
CAL12_RS19540	COG2917	probably involved in intracellular septation
CAL12_RS19545	COG0271	Belongs to the BolA IbaG family
CAL12_RS19550	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CAL12_RS19555	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CAL12_RS19565	COG1196	nuclear chromosome segregation
CAL12_RS19570	COG0477	Major facilitator Superfamily
CAL12_RS19575	COG1573	uracil-dna glycosylase
CAL12_RS19580	COG1214	PFAM Peptidase M22, glycoprotease
CAL12_RS19595	COG0450	alkyl hydroperoxide reductase
CAL12_RS19600	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CAL12_RS19605	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CAL12_RS19610	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CAL12_RS19615	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CAL12_RS19620	COG0560	Phosphoserine phosphatase
CAL12_RS19630	COG4774	siderophore transport
CAL12_RS19645	COG1007	ATP synthesis coupled electron transport
CAL12_RS19660	COG0713	ATP synthesis coupled electron transport
CAL12_RS19670	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CAL12_RS19675	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CAL12_RS19680	COG1034	ATP synthesis coupled electron transport
CAL12_RS19690	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
CAL12_RS19695	COG0649	NAD binding
CAL12_RS19700	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CAL12_RS19705	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CAL12_RS19710	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CAL12_RS19715	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CAL12_RS19720	COG0405	Gamma-glutamyltransferase
CAL12_RS19730	COG0583	DNA-binding transcription factor activity
CAL12_RS19740	COG2133	pyrroloquinoline quinone binding
CAL12_RS19745	COG1733	regulation of RNA biosynthetic process
CAL12_RS19750	COG0668	transmembrane transport
CAL12_RS19760	COG1012	belongs to the aldehyde dehydrogenase family
CAL12_RS19765	COG2204	response regulator
CAL12_RS19780	COG0583	DNA-binding transcription factor activity
CAL12_RS19785	COG1064	alcohol dehydrogenase
CAL12_RS19795	COG3265	gluconokinase activity
CAL12_RS19815	COG0477	Major facilitator Superfamily
CAL12_RS19820	COG0583	DNA-binding transcription factor activity
CAL12_RS19825	COG3181	Tripartite tricarboxylate transporter family receptor
CAL12_RS19840	COG2814	Major facilitator Superfamily
CAL12_RS19845	COG2972	Histidine kinase
CAL12_RS19850	COG3279	Response regulator of the LytR AlgR family
CAL12_RS19855	COG2203	Gaf domain
CAL12_RS19855	COG5001	Diguanylate cyclase
CAL12_RS19855	COG4251	negative regulation of phosphorylation
CAL12_RS19855	COG3706	GGDEF domain
CAL12_RS19865	COG3220	belongs to the UPF0276 family
CAL12_RS19885	COG1595	DNA-templated transcription, initiation
CAL12_RS19890	COG4944	Protein of unknown function (DUF1109)
CAL12_RS19895	COG3685	Protein conserved in bacteria
CAL12_RS19900	COG3546	catalase activity
CAL12_RS19910	COG1028	Short-chain dehydrogenase reductase Sdr
CAL12_RS19915	COG2116	formate transmembrane transporter activity
CAL12_RS19935	COG0390	transport system, permease component
CAL12_RS19940	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CAL12_RS19945	COG0728	peptidoglycan biosynthetic process
CAL12_RS19950	COG3181	Tripartite tricarboxylate transporter family receptor
CAL12_RS19960	COG1522	sequence-specific DNA binding
CAL12_RS19970	COG1595	DNA-templated transcription, initiation
CAL12_RS19990	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CAL12_RS20020	COG1802	Transcriptional regulator
CAL12_RS20030	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CAL12_RS20040	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CAL12_RS20045	COG0149	triose-phosphate isomerase activity
CAL12_RS20060	COG0028	Belongs to the TPP enzyme family
CAL12_RS20080	COG4608	Belongs to the ABC transporter superfamily
CAL12_RS20085	COG0444	Belongs to the ABC transporter superfamily
CAL12_RS20090	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CAL12_RS20095	COG0601	transmembrane transport
CAL12_RS20110	COG1027	Aspartate ammonia-lyase
CAL12_RS20115	COG1012	belongs to the aldehyde dehydrogenase family
CAL12_RS20145	COG0582	viral genome integration into host DNA
CAL12_RS20250	COG2948	multi-organism process
CAL12_RS20290	COG1674	ftsk spoiiie
CAL12_RS20310	COG0326	Molecular chaperone. Has ATPase activity
CAL12_RS20360	COG2003	Belongs to the UPF0758 family
CAL12_RS20405	COG1278	Cold shock
CAL12_RS20410	COG0745	RESPONSE REGULATOR receiver
CAL12_RS20415	COG0628	permease
CAL12_RS20420	COG3459	Glycosyltransferase 36 associated
CAL12_RS20430	COG2801	Transposase and inactivated derivatives
CAL12_RS20440	COG1278	Cold shock
CAL12_RS20445	COG1309	transcriptional regulator
CAL12_RS20480	COG0251	oxidation-reduction process
CAL12_RS20485	COG1028	Short-chain dehydrogenase reductase Sdr
CAL12_RS20490	COG0477	Major facilitator Superfamily
CAL12_RS20500	COG3813	Protein conserved in bacteria
CAL12_RS20505	COG1902	pentaerythritol trinitrate reductase activity
CAL12_RS20595	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
CAL12_RS20600	COG0583	DNA-binding transcription factor activity
CAL12_RS20620	COG0840	transmembrane signaling receptor activity
CAL12_RS20625	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CAL12_RS20630	COG0583	DNA-binding transcription factor activity
CAL12_RS20650	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
CAL12_RS20655	COG4221	oxidoreductase activity
CAL12_RS20660	COG2207	Transcriptional regulator
CAL12_RS20665	COG2080	2 iron, 2 sulfur cluster binding
CAL12_RS20670	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
CAL12_RS20675	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CAL12_RS20680	COG3181	Tripartite tricarboxylate transporter family receptor
CAL12_RS20685	COG3473	Maleate cis-trans isomerase
CAL12_RS20720	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
CAL12_RS20725	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CAL12_RS20745	COG3181	Tripartite tricarboxylate transporter family receptor
CAL12_RS20750	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CAL12_RS20760	COG0583	DNA-binding transcription factor activity
CAL12_RS20765	COG0667	Aldo Keto reductase
CAL12_RS20770	COG3181	Tripartite tricarboxylate transporter family receptor
CAL12_RS20790	COG0300	oxidoreductase activity
CAL12_RS20815	COG1053	succinate dehydrogenase
CAL12_RS20830	COG3181	Tripartite tricarboxylate transporter family receptor
CAL12_RS20835	COG0583	DNA-binding transcription factor activity
CAL12_RS20855	COG1028	Short-chain dehydrogenase reductase Sdr
CAL12_RS20860	COG0583	DNA-binding transcription factor activity
CAL12_RS20870	COG2423	ornithine cyclodeaminase activity
CAL12_RS20880	COG2814	Major facilitator Superfamily
CAL12_RS20885	COG0583	DNA-binding transcription factor activity
CAL12_RS20890	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
CAL12_RS20900	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CAL12_RS20910	COG1185	polyribonucleotide nucleotidyltransferase activity
CAL12_RS20915	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CAL12_RS20925	COG1183	phosphatidylcholine synthase activity
CAL12_RS20930	COG0688	phosphatidylethanolamine metabolic process
CAL12_RS20935	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CAL12_RS20940	COG0440	acetolactate synthase activity
CAL12_RS20945	COG0028	Belongs to the TPP enzyme family
CAL12_RS20950	COG1289	transmembrane transporter activity
CAL12_RS20955	COG3022	response to hydroperoxide
CAL12_RS20960	COG1028	Short-chain dehydrogenase reductase Sdr
CAL12_RS20990	COG0583	DNA-binding transcription factor activity
CAL12_RS21040	COG0477	Major facilitator Superfamily
CAL12_RS21090	COG1742	UPF0060 membrane protein
CAL12_RS21110	COG3181	Tripartite tricarboxylate transporter family receptor
CAL12_RS21115	COG0583	DNA-binding transcription factor activity
CAL12_RS21130	COG3938	Belongs to the proline racemase family
CAL12_RS21135	COG0154	amidase activity
CAL12_RS21140	COG1126	abc transporter atp-binding protein
CAL12_RS21145	COG0765	amino acid transport
CAL12_RS21150	COG0765	amino acid transport
CAL12_RS21160	COG0747	negative chemotaxis
CAL12_RS21180	COG0431	NADPH-dependent FMN reductase
CAL12_RS21220	COG1012	belongs to the aldehyde dehydrogenase family
CAL12_RS21250	COG1252	NADH dehydrogenase
CAL12_RS21260	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CAL12_RS21265	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CAL12_RS21270	COG0477	Major facilitator Superfamily
CAL12_RS21275	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CAL12_RS21280	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CAL12_RS21285	COG1845	cytochrome c oxidase, subunit III
CAL12_RS21290	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
CAL12_RS21305	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
CAL12_RS21310	COG2207	Transcriptional regulator
CAL12_RS21315	COG0667	Aldo Keto reductase
CAL12_RS21325	COG2197	response regulator
CAL12_RS21330	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CAL12_RS21330	COG2205	protein histidine kinase activity
CAL12_RS21340	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
CAL12_RS21345	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CAL12_RS21350	COG1271	oxidase subunit
CAL12_RS21355	COG1294	oxidase, subunit
CAL12_RS21370	COG3181	Tripartite tricarboxylate transporter family receptor
CAL12_RS21375	COG2188	Transcriptional regulator
CAL12_RS21385	COG1309	transcriptional regulator
CAL12_RS21390	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CAL12_RS21395	COG0179	Fumarylacetoacetate (FAA) hydrolase
CAL12_RS21405	COG2080	2 iron, 2 sulfur cluster binding
CAL12_RS21410	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CAL12_RS21410	COG2010	Cytochrome c
CAL12_RS21435	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CAL12_RS21440	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CAL12_RS21475	COG0747	negative chemotaxis
CAL12_RS21480	COG0601	transmembrane transport
CAL12_RS21500	COG1737	Transcriptional regulator
CAL12_RS21505	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
CAL12_RS21510	COG0251	oxidation-reduction process
CAL12_RS21515	COG0583	DNA-binding transcription factor activity
CAL12_RS21520	COG1960	acyl-CoA dehydrogenase activity
CAL12_RS21530	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CAL12_RS21540	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CAL12_RS21545	COG1674	ftsk spoiiie
CAL12_RS21550	COG0492	ferredoxin-NADP+ reductase activity
CAL12_RS21555	COG1193	negative regulation of DNA recombination
CAL12_RS21565	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CAL12_RS21580	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
CAL12_RS21585	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
CAL12_RS21590	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
CAL12_RS21595	COG2205	protein histidine kinase activity
CAL12_RS21600	COG0745	RESPONSE REGULATOR receiver
CAL12_RS21645	COG0154	amidase activity
CAL12_RS21650	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CAL12_RS21660	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CAL12_RS21695	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CAL12_RS21715	COG0612	Peptidase, M16
CAL12_RS21720	COG2010	Cytochrome c
CAL12_RS21720	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CAL12_RS21725	COG2080	2 iron, 2 sulfur cluster binding
CAL12_RS21730	COG2010	Cytochrome c
CAL12_RS21730	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CAL12_RS21735	COG0667	Aldo Keto reductase
CAL12_RS21775	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CAL12_RS21790	COG0583	DNA-binding transcription factor activity
CAL12_RS21795	COG2814	Major facilitator Superfamily
CAL12_RS21800	COG2721	sulfolactate sulfo-lyase activity
CAL12_RS21805	COG2186	Transcriptional regulator
CAL12_RS21815	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CAL12_RS21820	COG0765	amino acid transport
CAL12_RS21825	COG1126	abc transporter atp-binding protein
CAL12_RS21840	COG0625	glutathione transferase activity
CAL12_RS21845	COG1309	transcriptional regulator
CAL12_RS21850	COG1917	Cupin 2, conserved barrel domain protein
CAL12_RS21850	COG4977	sequence-specific DNA binding
CAL12_RS21860	COG3829	transcription factor binding
CAL12_RS21870	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CAL12_RS21875	COG0066	3-isopropylmalate dehydratase activity
CAL12_RS21885	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CAL12_RS21910	COG1278	Cold shock
CAL12_RS21915	COG3866	Pectate lyase
CAL12_RS21925	COG4783	chaperone-mediated protein folding
CAL12_RS21925	COG1560	Kdo2-lipid A biosynthetic process
CAL12_RS21950	COG0438	transferase activity, transferring glycosyl groups
CAL12_RS21955	COG0457	Tetratricopeptide repeat
CAL12_RS21995	COG2982	Protein involved in outer membrane biogenesis
CAL12_RS22000	COG1368	sulfuric ester hydrolase activity
CAL12_RS22015	COG5001	Diguanylate cyclase
CAL12_RS22015	COG3300	MHYT domain
CAL12_RS22020	COG0840	transmembrane signaling receptor activity
CAL12_RS22030	COG1595	DNA-templated transcription, initiation
CAL12_RS22040	COG4792	protein secretion
CAL12_RS22045	COG4791	protein targeting
CAL12_RS22050	COG4794	Type iii secretion
CAL12_RS22055	COG4790	Type iii secretion
CAL12_RS22090	COG4669	(LipO)protein
CAL12_RS22135	COG4789	Type iii secretion
CAL12_RS22165	COG2197	response regulator
CAL12_RS22190	COG2011	ABC-type metal ion transport system permease component
CAL12_RS22195	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CAL12_RS22215	COG0318	PFAM AMP-dependent synthetase and ligase
CAL12_RS22220	COG1473	amidohydrolase
CAL12_RS22230	COG2855	membrane
CAL12_RS22240	COG2239	Acts as a magnesium transporter
CAL12_RS22260	COG2985	domain, Protein
CAL12_RS22270	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CAL12_RS22270	COG3008	intermembrane lipid transfer
CAL12_RS22275	COG2995	paraquat-inducible protein a
CAL12_RS22285	COG4566	intracellular signal transduction
CAL12_RS22290	COG4191	Histidine kinase
CAL12_RS22305	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CAL12_RS22310	COG3064	Membrane
CAL12_RS22330	COG1522	sequence-specific DNA binding
CAL12_RS22345	COG0028	Belongs to the TPP enzyme family
CAL12_RS22350	COG3181	Tripartite tricarboxylate transporter family receptor
CAL12_RS22365	COG0653	protein targeting
CAL12_RS22370	COG0739	heme binding
CAL12_RS22380	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
CAL12_RS22395	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CAL12_RS22400	COG1181	Belongs to the D-alanine--D-alanine ligase family
CAL12_RS22405	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CAL12_RS22420	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CAL12_RS22425	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CAL12_RS22430	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CAL12_RS22440	COG3116	cell division
CAL12_RS22445	COG0275	rRNA processing
CAL12_RS22450	COG2001	Belongs to the MraZ family
CAL12_RS22460	COG3511	phospholipase C
CAL12_RS22470	COG0488	(ABC) transporter
CAL12_RS22475	COG0418	dihydroorotase activity
CAL12_RS22480	COG1473	amidohydrolase
CAL12_RS22535	COG0129	dihydroxy-acid dehydratase activity
CAL12_RS22540	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CAL12_RS22580	COG2084	Dehydrogenase
CAL12_RS22585	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CAL12_RS22600	COG0642	Histidine kinase
CAL12_RS22615	COG0442	prolyl-tRNA aminoacylation
CAL12_RS22620	COG0824	Thioesterase
CAL12_RS22625	COG0811	peptide transport
CAL12_RS22630	COG0848	biopolymer transport protein
CAL12_RS22640	COG0823	Involved in the tonB-independent uptake of proteins
CAL12_RS22655	COG4139	cobalamin transport
CAL12_RS22660	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CAL12_RS22740	COG2267	carboxylic ester hydrolase activity
CAL12_RS22750	COG1285	pathogenesis
CAL12_RS22755	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CAL12_RS22760	COG0784	Response regulator, receiver
CAL12_RS22760	COG2205	protein histidine kinase activity
CAL12_RS22760	COG2198	Histidine kinase
CAL12_RS22765	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CAL12_RS22795	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CAL12_RS22830	COG1940	carbohydrate kinase activity
CAL12_RS22840	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CAL12_RS22845	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
CAL12_RS22850	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CAL12_RS22855	COG0561	phosphatase activity
CAL12_RS22860	COG0363	glucosamine-6-phosphate deaminase activity
CAL12_RS22865	COG4948	Mandelate Racemase Muconate Lactonizing
CAL12_RS22870	COG0583	DNA-binding transcription factor activity
CAL12_RS22880	COG0583	DNA-binding transcription factor activity
CAL12_RS22910	COG4948	Mandelate Racemase Muconate Lactonizing
CAL12_RS22925	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CAL12_RS22935	COG0477	Major facilitator Superfamily
CAL12_RS22945	COG1196	nuclear chromosome segregation
CAL12_RS22945	COG0741	lytic transglycosylase activity
CAL12_RS22945	COG0739	heme binding
CAL12_RS22960	COG5265	(ABC) transporter
CAL12_RS22965	COG0438	transferase activity, transferring glycosyl groups
CAL12_RS22970	COG1028	Short-chain dehydrogenase reductase Sdr
CAL12_RS22975	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CAL12_RS22985	COG2192	nodulation
CAL12_RS23005	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CAL12_RS23045	COG0583	DNA-binding transcription factor activity
CAL12_RS23080	COG0783	Belongs to the Dps family
CAL12_RS23085	COG4941	Belongs to the sigma-70 factor family
CAL12_RS23090	COG3795	YCII-related domain
CAL12_RS23100	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CAL12_RS23105	COG2733	membrane
CAL12_RS23120	COG0154	amidase activity
CAL12_RS23130	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CAL12_RS23135	COG1116	anion transmembrane transporter activity
CAL12_RS23150	COG2200	EAL domain
CAL12_RS23155	COG2814	Major facilitator Superfamily
CAL12_RS23160	COG0679	Auxin Efflux Carrier
CAL12_RS23165	COG0583	DNA-binding transcription factor activity
CAL12_RS23170	COG1132	(ABC) transporter
CAL12_RS23215	COG2186	Transcriptional regulator
CAL12_RS23220	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CAL12_RS23225	COG1981	membrane
CAL12_RS23235	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CAL12_RS23240	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CAL12_RS23250	COG5002	protein histidine kinase activity
CAL12_RS23255	COG3468	outer membrane autotransporter barrel domain protein
CAL12_RS23260	COG3468	outer membrane autotransporter barrel domain protein
CAL12_RS23275	COG0583	DNA-binding transcription factor activity
CAL12_RS23295	COG0583	DNA-binding transcription factor activity
CAL12_RS23310	COG4172	Belongs to the ABC transporter superfamily
CAL12_RS23315	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CAL12_RS23320	COG0601	transmembrane transport
CAL12_RS23325	COG0154	amidase activity
CAL12_RS23340	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CAL12_RS23360	COG0402	S-adenosylhomocysteine deaminase activity
CAL12_RS23365	COG0583	DNA-binding transcription factor activity
CAL12_RS23380	COG3181	Tripartite tricarboxylate transporter family receptor
CAL12_RS23390	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CAL12_RS23400	COG0129	dihydroxy-acid dehydratase activity
CAL12_RS23405	COG3181	Tripartite tricarboxylate transporter family receptor
CAL12_RS23420	COG5265	(ABC) transporter
CAL12_RS23470	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CAL12_RS23480	COG0251	oxidation-reduction process
CAL12_RS23505	COG2267	carboxylic ester hydrolase activity
CAL12_RS23510	COG0302	gtp cyclohydrolase
CAL12_RS23525	COG1228	amidohydrolase
CAL12_RS23535	COG1175	transmembrane transport
CAL12_RS23540	COG1176	ABC-type spermidine putrescine transport system, permease component I
CAL12_RS23545	COG3842	ATPase activity
CAL12_RS23550	COG1902	pentaerythritol trinitrate reductase activity
CAL12_RS23585	COG1113	amino acid transport
CAL12_RS23610	COG0701	Predicted permease
CAL12_RS23725	COG2203	Gaf domain
CAL12_RS23725	COG3706	GGDEF domain
CAL12_RS23725	COG5001	Diguanylate cyclase
CAL12_RS23725	COG4251	negative regulation of phosphorylation
CAL12_RS23730	COG0835	chemotaxis
CAL12_RS23735	COG0840	transmembrane signaling receptor activity
CAL12_RS23740	COG0643	Histidine kinase
CAL12_RS23740	COG2198	Histidine kinase
CAL12_RS23750	COG2201	protein-glutamate methylesterase activity
CAL12_RS23765	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CAL12_RS23785	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CAL12_RS23805	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CAL12_RS23820	COG3181	Tripartite tricarboxylate transporter family receptor
CAL12_RS23830	COG1418	mRNA catabolic process
CAL12_RS23840	COG0668	transmembrane transport
CAL12_RS23860	COG0583	DNA-binding transcription factor activity
CAL12_RS23875	COG1028	Short-chain dehydrogenase reductase Sdr
CAL12_RS23895	COG0678	peroxiredoxin activity
CAL12_RS23900	COG0412	Dienelactone hydrolase
CAL12_RS23910	COG0315	cyclic pyranopterin monophosphate synthase activity
CAL12_RS23925	COG0521	Mo-molybdopterin cofactor biosynthetic process
CAL12_RS23930	COG0303	'Molybdopterin
CAL12_RS23935	COG0746	molybdenum cofactor guanylyltransferase activity
CAL12_RS23940	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CAL12_RS23960	COG3383	formate dehydrogenase (NAD+) activity
CAL12_RS23965	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CAL12_RS23975	COG2223	nitrite transmembrane transporter activity
CAL12_RS23990	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CAL12_RS23995	COG0697	spore germination
CAL12_RS24015	COG1802	Transcriptional regulator
CAL12_RS24030	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CAL12_RS24035	COG0463	Glycosyl transferase, family 2
CAL12_RS24040	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CAL12_RS24045	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CAL12_RS24045	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CAL12_RS24050	COG1609	Transcriptional regulator
CAL12_RS24065	COG3530	Putative quorum-sensing-regulated virulence factor
CAL12_RS24070	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
CAL12_RS24080	COG4166	transmembrane transport
CAL12_RS24085	COG0601	transmembrane transport
CAL12_RS24090	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CAL12_RS24095	COG0444	Belongs to the ABC transporter superfamily
CAL12_RS24100	COG4608	Belongs to the ABC transporter superfamily
CAL12_RS24105	COG0154	amidase activity
CAL12_RS24110	COG0277	FAD linked oxidase domain protein
CAL12_RS24120	COG0583	DNA-binding transcription factor activity
CAL12_RS24125	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CAL12_RS24135	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CAL12_RS24145	COG0765	amino acid transport
CAL12_RS24150	COG0765	amino acid transport
CAL12_RS24175	COG3181	Tripartite tricarboxylate transporter family receptor
CAL12_RS24185	COG1024	Enoyl-CoA hydratase
CAL12_RS24190	COG1414	Transcriptional regulator
CAL12_RS24195	COG1295	ribonuclease BN
CAL12_RS24205	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CAL12_RS24230	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CAL12_RS24235	COG0328	RNA-DNA hybrid ribonuclease activity
CAL12_RS24240	COG2226	methyltransferase
CAL12_RS24245	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CAL12_RS24250	COG0741	lytic transglycosylase activity
CAL12_RS24250	COG1388	LysM domain
CAL12_RS24275	COG0667	Aldo Keto reductase
CAL12_RS24290	COG0154	amidase activity
CAL12_RS24295	COG4166	transmembrane transport
CAL12_RS24300	COG0601	transmembrane transport
CAL12_RS24305	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CAL12_RS24310	COG4608	Belongs to the ABC transporter superfamily
CAL12_RS24320	COG0154	amidase activity
CAL12_RS24330	COG0154	amidase activity
CAL12_RS24335	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CAL12_RS24340	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
CAL12_RS24345	COG2080	2 iron, 2 sulfur cluster binding
CAL12_RS24350	COG2205	protein histidine kinase activity
CAL12_RS24350	COG2198	Histidine kinase
CAL12_RS24350	COG0784	Response regulator, receiver
CAL12_RS24360	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CAL12_RS24365	COG2814	Major facilitator Superfamily
CAL12_RS24375	COG0165	Argininosuccinate lyase
CAL12_RS24380	COG3214	Protein conserved in bacteria
CAL12_RS24395	COG1881	PFAM PEBP family protein
CAL12_RS24400	COG4566	intracellular signal transduction
CAL12_RS24410	COG1028	Short-chain dehydrogenase reductase Sdr
CAL12_RS24430	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CAL12_RS24435	COG3181	Tripartite tricarboxylate transporter family receptor
CAL12_RS24460	COG5592	hemerythrin HHE cation binding domain
CAL12_RS24490	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CAL12_RS24525	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CAL12_RS24530	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
CAL12_RS24540	COG4166	transmembrane transport
CAL12_RS24545	COG0583	DNA-binding transcription factor activity
CAL12_RS24585	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CAL12_RS24645	COG1335	isochorismatase
CAL12_RS24655	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CAL12_RS24660	COG0601	transmembrane transport
CAL12_RS24670	COG4172	Belongs to the ABC transporter superfamily
CAL12_RS24675	COG2719	SpoVR family
CAL12_RS24680	COG2718	Belongs to the UPF0229 family
CAL12_RS24685	COG2766	serine protein kinase
CAL12_RS24695	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CAL12_RS24695	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CAL12_RS24700	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CAL12_RS24705	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CAL12_RS24710	COG1881	PFAM PEBP family protein
CAL12_RS24715	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CAL12_RS24720	COG0739	heme binding
CAL12_RS24725	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
CAL12_RS24730	COG0316	Belongs to the HesB IscA family
CAL12_RS24740	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CAL12_RS24745	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CAL12_RS24750	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CAL12_RS24765	COG4177	L-phenylalanine transmembrane transporter activity
CAL12_RS24780	COG0312	modulator of DNA gyrase
CAL12_RS24785	COG3028	Belongs to the UPF0307 family
CAL12_RS24800	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CAL12_RS24810	COG0583	DNA-binding transcription factor activity
CAL12_RS24825	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CAL12_RS24825	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CAL12_RS24830	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CAL12_RS24850	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CAL12_RS24860	COG2264	protein methyltransferase activity
CAL12_RS24865	COG0439	Biotin carboxylase
CAL12_RS24870	COG0511	ligase activity, forming carbon-carbon bonds
CAL12_RS24875	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CAL12_RS24880	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CAL12_RS24885	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CAL12_RS24895	COG0557	exoribonuclease II activity
CAL12_RS24920	COG3842	ATPase activity
CAL12_RS24930	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CAL12_RS24935	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CAL12_RS24945	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CAL12_RS24955	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CAL12_RS24960	COG1678	Uncharacterized ACR, COG1678
CAL12_RS24975	COG0352	thiamine-phosphate diphosphorylase activity
CAL12_RS24980	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CAL12_RS25000	COG1024	Enoyl-CoA hydratase
CAL12_RS25005	COG1028	Short-chain dehydrogenase reductase Sdr
CAL12_RS25040	COG0411	ABC transporter
CAL12_RS25075	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CAL12_RS25105	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CAL12_RS25110	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
CAL12_RS25115	COG0237	dephospho-CoA kinase activity
CAL12_RS25135	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CAL12_RS25140	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CAL12_RS25150	COG0477	Major facilitator Superfamily
CAL12_RS25170	COG0625	glutathione transferase activity
CAL12_RS25175	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CAL12_RS25180	COG3181	Tripartite tricarboxylate transporter family receptor
CAL12_RS25210	COG0625	glutathione transferase activity
CAL12_RS25225	COG4221	oxidoreductase activity
CAL12_RS25225	COG3321	synthase
CAL12_RS25225	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CAL12_RS25225	COG0604	alcohol dehydrogenase
CAL12_RS25240	COG1126	abc transporter atp-binding protein
CAL12_RS25245	COG0765	amino acid transport
CAL12_RS25250	COG4597	amino acid ABC transporter
CAL12_RS25255	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CAL12_RS25260	COG2884	Cell division ATP-binding protein ftsE
CAL12_RS25265	COG2177	Part of the ABC transporter FtsEX involved in
CAL12_RS25270	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
CAL12_RS25280	COG1194	a g-specific adenine glycosylase
CAL12_RS25285	COG0772	Belongs to the SEDS family
CAL12_RS25290	COG0768	penicillin binding
CAL12_RS25300	COG1792	Involved in formation and maintenance of cell shape
CAL12_RS25305	COG1077	Cell shape determining protein MreB Mrl
CAL12_RS25310	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CAL12_RS25315	COG0154	amidase activity
CAL12_RS25320	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CAL12_RS25325	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CAL12_RS25330	COG0708	Exodeoxyribonuclease III
CAL12_RS25340	COG0589	response to stress
CAL12_RS25350	COG2223	nitrite transmembrane transporter activity
CAL12_RS25355	COG2813	Specifically methylates the guanine in position
CAL12_RS25355	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CAL12_RS25360	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CAL12_RS25365	COG2197	response regulator
CAL12_RS25375	COG2918	glutathione biosynthetic process
CAL12_RS25395	COG0473	3-isopropylmalate dehydrogenase activity
CAL12_RS25405	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CAL12_RS25415	COG0583	DNA-binding transcription factor activity
CAL12_RS25420	COG1028	Short-chain dehydrogenase reductase Sdr
CAL12_RS25440	COG3245	cytochrome
CAL12_RS25455	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CAL12_RS25455	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CAL12_RS25460	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CAL12_RS25475	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CAL12_RS25490	COG0697	spore germination
CAL12_RS25495	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CAL12_RS25500	COG0765	amino acid transport
CAL12_RS25505	COG0765	amino acid transport
CAL12_RS25510	COG1126	abc transporter atp-binding protein
CAL12_RS25520	COG3665	Urea carboxylase-associated protein
CAL12_RS25540	COG4206	TonB-dependent receptor
CAL12_RS25545	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CAL12_RS25555	COG2022	thiamine diphosphate biosynthetic process
CAL12_RS25560	COG0351	phosphomethylpyrimidine kinase
CAL12_RS25565	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CAL12_RS25570	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CAL12_RS25580	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CAL12_RS25595	COG2226	methyltransferase
CAL12_RS25600	COG0745	RESPONSE REGULATOR receiver
CAL12_RS25605	COG5002	protein histidine kinase activity
CAL12_RS25610	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CAL12_RS25625	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CAL12_RS25630	COG1984	allophanate hydrolase subunit 2
CAL12_RS25640	COG1802	Transcriptional regulator
CAL12_RS25650	COG1238	metal cluster binding
CAL12_RS25655	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CAL12_RS25675	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CAL12_RS25690	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CAL12_RS25695	COG0583	DNA-binding transcription factor activity
CAL12_RS25705	COG0601	transmembrane transport
CAL12_RS25710	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CAL12_RS25715	COG0444	Belongs to the ABC transporter superfamily
CAL12_RS25720	COG4608	Belongs to the ABC transporter superfamily
CAL12_RS25765	COG0210	DNA helicase
CAL12_RS25770	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CAL12_RS25775	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CAL12_RS25790	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CAL12_RS25795	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CAL12_RS25800	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CAL12_RS25805	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CAL12_RS25810	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CAL12_RS25825	COG0356	it plays a direct role in the translocation of protons across the membrane
CAL12_RS25840	COG1024	Enoyl-CoA hydratase
CAL12_RS25845	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CAL12_RS25850	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
CAL12_RS25855	COG3634	alkyl hydroperoxide reductase activity
CAL12_RS25865	COG0037	tRNA processing
CAL12_RS25870	COG0163	prenyltransferase activity
CAL12_RS25875	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CAL12_RS25880	COG2890	protein-(glutamine-N5) methyltransferase activity
CAL12_RS25885	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CAL12_RS25930	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CAL12_RS25935	COG1126	abc transporter atp-binding protein
CAL12_RS25940	COG0765	amino acid transport
CAL12_RS25945	COG0765	amino acid transport
CAL12_RS25950	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CAL12_RS25955	COG4948	Mandelate Racemase Muconate Lactonizing
CAL12_RS25975	COG0384	phenazine biosynthesis protein PhzF
CAL12_RS25985	COG1686	Belongs to the peptidase S11 family
CAL12_RS25990	COG2818	Glycosylase
CAL12_RS26020	COG3069	C4-dicarboxylate transmembrane transporter activity
CAL12_RS26025	COG1802	Transcriptional regulator
CAL12_RS26065	COG2943	transferase activity, transferring hexosyl groups
CAL12_RS26070	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CAL12_RS26075	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CAL12_RS26080	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CAL12_RS26085	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
CAL12_RS26090	COG2967	ApaG domain
CAL12_RS26095	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CAL12_RS26100	COG0546	phosphoglycolate phosphatase activity
CAL12_RS26110	COG0512	Glutamine amidotransferase of anthranilate synthase
CAL12_RS26115	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CAL12_RS26125	COG1607	acyl-coa hydrolase
CAL12_RS26135	COG3387	PFAM Glycoside hydrolase 15-related
CAL12_RS26140	COG2814	Major facilitator Superfamily
CAL12_RS26150	COG0235	Class ii aldolase
CAL12_RS26160	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CAL12_RS26170	COG1309	transcriptional regulator
CAL12_RS26175	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CAL12_RS26180	COG0793	Belongs to the peptidase S41A family
CAL12_RS26185	COG4942	peptidase
CAL12_RS26190	COG0588	phosphoglycerate mutase activity
CAL12_RS26205	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
CAL12_RS26210	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CAL12_RS26230	COG1040	competence protein
CAL12_RS26235	COG2226	methyltransferase
CAL12_RS26240	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
CAL12_RS26245	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CAL12_RS26250	COG0569	domain protein
CAL12_RS26255	COG2204	response regulator
CAL12_RS26260	COG5000	phosphorelay sensor kinase activity
CAL12_RS26285	COG0642	Histidine kinase
CAL12_RS26290	COG0583	DNA-binding transcription factor activity
CAL12_RS26295	COG0626	cystathionine gamma-synthase activity
CAL12_RS26300	COG0765	amino acid transport
CAL12_RS26305	COG1126	abc transporter atp-binding protein
CAL12_RS26310	COG3608	succinylglutamate desuccinylase aspartoacylase
CAL12_RS26315	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CAL12_RS26320	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CAL12_RS26345	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CAL12_RS26375	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CAL12_RS26380	COG0242	peptide deformylase activity
CAL12_RS26385	COG0758	DNA mediated transformation
CAL12_RS26400	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CAL12_RS26460	COG1172	Belongs to the binding-protein-dependent transport system permease family
CAL12_RS26500	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CAL12_RS26510	COG1850	ribulose-bisphosphate carboxylase activity
CAL12_RS26520	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CAL12_RS26525	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CAL12_RS26530	COG0583	DNA-binding transcription factor activity
CAL12_RS26555	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CAL12_RS26560	COG0513	Belongs to the DEAD box helicase family
CAL12_RS26570	COG0617	tRNA 3'-terminal CCA addition
CAL12_RS26580	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CAL12_RS26585	COG2308	Evidence 4 Homologs of previously reported genes of
CAL12_RS26595	COG1305	Transglutaminase-like
CAL12_RS26605	COG2134	cdp-diacylglycerol pyrophosphatase
CAL12_RS26615	COG1950	PFAM Membrane protein of
CAL12_RS26625	COG0438	transferase activity, transferring glycosyl groups
CAL12_RS26640	COG0066	3-isopropylmalate dehydratase activity
CAL12_RS26645	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CAL12_RS26650	COG0583	DNA-binding transcription factor activity
CAL12_RS26655	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CAL12_RS26655	COG0784	Response regulator, receiver
CAL12_RS26655	COG2198	Histidine kinase
CAL12_RS26655	COG2205	protein histidine kinase activity
CAL12_RS26670	COG1366	Belongs to the anti-sigma-factor antagonist family
CAL12_RS26675	COG1366	Belongs to the anti-sigma-factor antagonist family
CAL12_RS26680	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CAL12_RS26695	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CAL12_RS26705	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
CAL12_RS26715	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CAL12_RS26725	COG0735	belongs to the Fur family
CAL12_RS26730	COG0523	cobalamin synthesis protein
CAL12_RS26740	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CAL12_RS26745	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CAL12_RS26755	COG2096	Adenosyltransferase
CAL12_RS26770	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CAL12_RS26785	COG2921	Belongs to the UPF0250 family
CAL12_RS26795	COG1686	Belongs to the peptidase S11 family
CAL12_RS26805	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CAL12_RS26825	COG1127	ABC transporter
CAL12_RS26830	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CAL12_RS26840	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CAL12_RS26865	COG0463	Glycosyl transferase, family 2
CAL12_RS26870	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CAL12_RS26875	COG3959	Transketolase, thiamine diphosphate binding domain
CAL12_RS26890	COG0859	PFAM glycosyl transferase family 9
CAL12_RS26910	COG0438	transferase activity, transferring glycosyl groups
CAL12_RS26950	COG0463	Glycosyl transferase, family 2
CAL12_RS26965	COG0493	'glutamate synthase
CAL12_RS26970	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CAL12_RS26985	COG0277	FAD linked oxidase domain protein
CAL12_RS26990	COG0546	phosphoglycolate phosphatase activity
CAL12_RS26990	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CAL12_RS26995	COG1216	Glycosyl transferase, family 2
CAL12_RS26995	COG0438	transferase activity, transferring glycosyl groups
CAL12_RS27010	COG1091	dTDP-4-dehydrorhamnose reductase activity
CAL12_RS27025	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CAL12_RS27040	COG0183	Belongs to the thiolase family
CAL12_RS27045	COG1024	Enoyl-CoA hydratase
CAL12_RS27045	COG1250	3-hydroxyacyl-CoA dehydrogenase
CAL12_RS27060	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CAL12_RS27085	COG3468	outer membrane autotransporter barrel domain protein
CAL12_RS27095	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CAL12_RS27100	COG1956	GAF domain-containing protein
CAL12_RS27105	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CAL12_RS27120	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CAL12_RS27125	COG1028	Short-chain dehydrogenase reductase Sdr
CAL12_RS27130	COG1840	ABC-type Fe3 transport system, periplasmic component
CAL12_RS27135	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CAL12_RS27150	COG1177	transmembrane transport
CAL12_RS27155	COG1176	ABC-type spermidine putrescine transport system, permease component I
CAL12_RS27160	COG3842	ATPase activity
CAL12_RS27165	COG1414	Transcriptional regulator
CAL12_RS27175	COG3550	peptidyl-serine autophosphorylation
CAL12_RS27180	COG0583	DNA-binding transcription factor activity
CAL12_RS27185	COG0583	DNA-binding transcription factor activity
CAL12_RS27190	COG3181	Tripartite tricarboxylate transporter family receptor
CAL12_RS27200	COG3181	Tripartite tricarboxylate transporter family receptor
CAL12_RS27215	COG0477	Major facilitator Superfamily
CAL12_RS27225	COG0154	amidase activity
CAL12_RS27235	COG0583	DNA-binding transcription factor activity
CAL12_RS27255	COG1012	belongs to the aldehyde dehydrogenase family
CAL12_RS27260	COG2188	Transcriptional regulator
CAL12_RS27295	COG1028	Short-chain dehydrogenase reductase Sdr
CAL12_RS27400	COG2814	Major facilitator Superfamily
CAL12_RS27420	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CAL12_RS27425	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CAL12_RS27430	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CAL12_RS27440	COG1965	Belongs to the frataxin family
CAL12_RS27455	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CAL12_RS27460	COG1333	cytochrome c biogenesis protein
CAL12_RS27470	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CAL12_RS27480	COG4232	protein-disulfide reductase activity
CAL12_RS27485	COG1324	tolerance protein
CAL12_RS27490	COG0203	ribosomal protein L17
CAL12_RS27495	COG0202	RNA polymerase activity
CAL12_RS27500	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CAL12_RS27505	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CAL12_RS27510	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CAL12_RS27515	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CAL12_RS27525	COG0201	protein transport
CAL12_RS27530	COG0200	Binds to the 23S rRNA
CAL12_RS27535	COG1841	ribosomal large subunit assembly
CAL12_RS27540	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CAL12_RS27545	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CAL12_RS27550	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CAL12_RS27555	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CAL12_RS27560	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CAL12_RS27565	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CAL12_RS27570	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CAL12_RS27575	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CAL12_RS27585	COG0583	DNA-binding transcription factor activity
CAL12_RS27595	COG0251	oxidation-reduction process
CAL12_RS27610	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CAL12_RS27615	COG0255	Belongs to the universal ribosomal protein uL29 family
CAL12_RS27620	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CAL12_RS27630	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CAL12_RS27635	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CAL12_RS27640	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CAL12_RS27645	COG0089	rRNA binding
CAL12_RS27655	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CAL12_RS27660	COG0051	transcription antitermination factor activity, RNA binding
CAL12_RS27665	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CAL12_RS27670	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CAL12_RS27675	COG0049	tRNA binding
CAL12_RS27680	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CAL12_RS27695	COG0765	amino acid transport
CAL12_RS27700	COG0765	amino acid transport
CAL12_RS27705	COG1126	abc transporter atp-binding protein
CAL12_RS27715	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
CAL12_RS27720	COG3181	Tripartite tricarboxylate transporter family receptor
CAL12_RS27735	COG0583	DNA-binding transcription factor activity
CAL12_RS27745	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CAL12_RS27750	COG0085	RNA polymerase activity
CAL12_RS27755	COG0222	ribosome binding
CAL12_RS27760	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CAL12_RS27765	COG0081	regulation of translation
CAL12_RS27770	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CAL12_RS27780	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CAL12_RS27790	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CAL12_RS27815	COG1012	belongs to the aldehyde dehydrogenase family
CAL12_RS27830	COG0252	asparaginase activity
CAL12_RS27835	COG1475	DNA binding
CAL12_RS27845	COG1192	Involved in chromosome partitioning
CAL12_RS27850	COG0357	Ribosomal RNA small subunit methyltransferase G
CAL12_RS27855	COG0445	tRNA wobble uridine modification
CAL12_RS27860	COG1278	Cold shock
CAL12_RS27865	COG0436	Aminotransferase
CAL12_RS27895	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CAL12_RS27900	COG0747	negative chemotaxis
CAL12_RS27910	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CAL12_RS27915	COG0444	Belongs to the ABC transporter superfamily
CAL12_RS27920	COG4608	Belongs to the ABC transporter superfamily
CAL12_RS27930	COG1473	amidohydrolase
CAL12_RS27940	COG1733	regulation of RNA biosynthetic process
CAL12_RS27945	COG0702	epimerase
CAL12_RS27950	COG1960	acyl-CoA dehydrogenase activity
CAL12_RS27965	COG0583	DNA-binding transcription factor activity
CAL12_RS27970	COG0706	membrane insertase activity
CAL12_RS27975	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CAL12_RS27980	COG0594	ribonuclease P activity
CAL12_RS27985	COG0230	Belongs to the bacterial ribosomal protein bL34 family