locus-tag	class	description
HHA22_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HHA22_RS00010	COG0592	DNA-directed DNA polymerase activity
HHA22_RS00025	COG1309	transcriptional regulator
HHA22_RS00030	COG1254	Belongs to the acylphosphatase family
HHA22_RS00035	COG1304	FMN binding
HHA22_RS00040	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HHA22_RS00055	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HHA22_RS00060	COG1960	acyl-CoA dehydrogenase activity
HHA22_RS00085	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HHA22_RS00095	COG0625	glutathione transferase activity
HHA22_RS00100	COG0402	S-adenosylhomocysteine deaminase activity
HHA22_RS00105	COG1079	Belongs to the binding-protein-dependent transport system permease family
HHA22_RS00110	COG4603	Belongs to the binding-protein-dependent transport system permease family
HHA22_RS00115	COG3845	ABC transporter
HHA22_RS00130	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HHA22_RS00135	COG2910	NAD(P)H-binding
HHA22_RS00155	COG0702	epimerase
HHA22_RS00165	COG3781	membrane
HHA22_RS00170	COG1522	sequence-specific DNA binding
HHA22_RS00175	COG0028	Belongs to the TPP enzyme family
HHA22_RS00185	COG1012	belongs to the aldehyde dehydrogenase family
HHA22_RS00190	COG1028	Short-chain dehydrogenase reductase Sdr
HHA22_RS00195	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HHA22_RS00200	COG3842	ATPase activity
HHA22_RS00220	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HHA22_RS00225	COG2922	Belongs to the Smg family
HHA22_RS00230	COG1629	transport
HHA22_RS00240	COG2358	TRAP transporter, solute receptor (TAXI family
HHA22_RS00250	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HHA22_RS00265	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HHA22_RS00270	COG0183	Belongs to the thiolase family
HHA22_RS00275	COG1960	acyl-CoA dehydrogenase activity
HHA22_RS00280	COG1473	amidohydrolase
HHA22_RS00310	COG2200	EAL domain
HHA22_RS00320	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HHA22_RS00330	COG0018	arginyl-trna synthetase
HHA22_RS00345	COG0395	ABC-type sugar transport system, permease component
HHA22_RS00350	COG1175	transmembrane transport
HHA22_RS00355	COG1653	transport
HHA22_RS00360	COG3842	ATPase activity
HHA22_RS00365	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HHA22_RS00370	COG3842	ATPase activity
HHA22_RS00385	COG1840	ABC-type Fe3 transport system, periplasmic component
HHA22_RS00395	COG0154	amidase activity
HHA22_RS00400	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HHA22_RS00410	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HHA22_RS00420	COG0583	DNA-binding transcription factor activity
HHA22_RS00440	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HHA22_RS00445	COG1280	lysine exporter protein (LysE YggA)
HHA22_RS00450	COG0513	Belongs to the DEAD box helicase family
HHA22_RS00460	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HHA22_RS00475	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HHA22_RS00480	COG0601	transmembrane transport
HHA22_RS00490	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HHA22_RS00510	COG0697	spore germination
HHA22_RS00525	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HHA22_RS00535	COG2969	positive regulation of protein catabolic process
HHA22_RS00540	COG0625	glutathione transferase activity
HHA22_RS00545	COG2857	Cytochrome c1
HHA22_RS00550	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HHA22_RS00555	COG0723	plastoquinol--plastocyanin reductase activity
HHA22_RS00560	COG1970	mechanosensitive ion channel activity
HHA22_RS00565	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HHA22_RS00570	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HHA22_RS00580	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HHA22_RS00585	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HHA22_RS00590	COG0537	adenosine 5'-monophosphoramidase activity
HHA22_RS00595	COG0140	phosphoribosyl-ATP diphosphatase activity
HHA22_RS00600	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HHA22_RS00605	COG0107	imidazoleglycerol-phosphate synthase activity
HHA22_RS00610	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HHA22_RS00620	COG0131	Imidazoleglycerol-phosphate dehydratase
HHA22_RS00625	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HHA22_RS00630	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HHA22_RS00635	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HHA22_RS00640	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HHA22_RS00650	COG0842	Transport permease protein
HHA22_RS00655	COG1131	(ABC) transporter
HHA22_RS00670	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HHA22_RS00675	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HHA22_RS00680	COG1127	ABC transporter
HHA22_RS00685	COG3047	cAMP biosynthetic process
HHA22_RS00695	COG0069	glutamate synthase activity
HHA22_RS00695	COG0070	glutamate synthase
HHA22_RS00695	COG0067	glutamate synthase
HHA22_RS00710	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
HHA22_RS00725	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HHA22_RS00730	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HHA22_RS00740	COG1609	Transcriptional regulator
HHA22_RS00745	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HHA22_RS00755	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HHA22_RS00795	COG0109	protoheme IX farnesyltransferase activity
HHA22_RS00800	COG1999	signal sequence binding
HHA22_RS00820	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HHA22_RS00825	COG2814	Major facilitator Superfamily
HHA22_RS00840	COG1522	sequence-specific DNA binding
HHA22_RS00950	COG2124	cytochrome p450
HHA22_RS00985	COG0559	Belongs to the binding-protein-dependent transport system permease family
HHA22_RS00995	COG1902	pentaerythritol trinitrate reductase activity
HHA22_RS01080	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HHA22_RS01090	COG1671	Belongs to the UPF0178 family
HHA22_RS01095	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HHA22_RS01120	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HHA22_RS01125	COG0443	Heat shock 70 kDa protein
HHA22_RS01135	COG3181	Tripartite tricarboxylate transporter family receptor
HHA22_RS01155	COG2169	Transcriptional regulator
HHA22_RS01155	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HHA22_RS01160	COG3145	DNA-N1-methyladenine dioxygenase activity
HHA22_RS01170	COG0583	DNA-binding transcription factor activity
HHA22_RS01180	COG1473	amidohydrolase
HHA22_RS01185	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HHA22_RS01190	COG1335	isochorismatase
HHA22_RS01200	COG1683	Conserved Protein
HHA22_RS01205	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HHA22_RS01225	COG1120	ATPase activity
HHA22_RS01230	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HHA22_RS01235	COG4558	Periplasmic binding protein
HHA22_RS01240	COG3720	iron ion transport
HHA22_RS01250	COG3712	iron ion homeostasis
HHA22_RS01255	COG1595	DNA-templated transcription, initiation
HHA22_RS01285	COG1607	acyl-coa hydrolase
HHA22_RS01300	COG0437	4 iron, 4 sulfur cluster binding
HHA22_RS01305	COG2864	formate dehydrogenase
HHA22_RS01320	COG3276	selenocysteine insertion sequence binding
HHA22_RS01340	COG0583	DNA-binding transcription factor activity
HHA22_RS01350	COG1028	Short-chain dehydrogenase reductase Sdr
HHA22_RS01365	COG0134	indole-3-glycerol-phosphate synthase activity
HHA22_RS01370	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HHA22_RS01375	COG0512	Glutamine amidotransferase of anthranilate synthase
HHA22_RS01385	COG0546	phosphoglycolate phosphatase activity
HHA22_RS01390	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HHA22_RS01395	COG2967	ApaG domain
HHA22_RS01400	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HHA22_RS01405	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HHA22_RS01410	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HHA22_RS01420	COG0037	tRNA processing
HHA22_RS01440	COG1024	Enoyl-CoA hydratase
HHA22_RS01455	COG0356	it plays a direct role in the translocation of protons across the membrane
HHA22_RS01465	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HHA22_RS01470	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HHA22_RS01475	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HHA22_RS01480	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HHA22_RS01485	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HHA22_RS01490	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HHA22_RS01500	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HHA22_RS01505	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HHA22_RS01510	COG0210	DNA helicase
HHA22_RS01525	COG4608	Belongs to the ABC transporter superfamily
HHA22_RS01530	COG0444	Belongs to the ABC transporter superfamily
HHA22_RS01535	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HHA22_RS01540	COG0601	transmembrane transport
HHA22_RS01550	COG0747	negative chemotaxis
HHA22_RS01560	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HHA22_RS01565	COG1024	Enoyl-CoA hydratase
HHA22_RS01570	COG1024	Enoyl-CoA hydratase
HHA22_RS01575	COG2070	2-Nitropropane dioxygenase
HHA22_RS01580	COG1309	transcriptional regulator
HHA22_RS01585	COG1960	acyl-CoA dehydrogenase activity
HHA22_RS01595	COG1250	3-hydroxyacyl-CoA dehydrogenase
HHA22_RS01600	COG3245	cytochrome
HHA22_RS01625	COG2918	glutathione biosynthetic process
HHA22_RS01645	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HHA22_RS01650	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HHA22_RS01655	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HHA22_RS01655	COG2813	Specifically methylates the guanine in position
HHA22_RS01660	COG2223	nitrite transmembrane transporter activity
HHA22_RS01665	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HHA22_RS01675	COG2860	membrane
HHA22_RS01680	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HHA22_RS01685	COG0708	Exodeoxyribonuclease III
HHA22_RS01690	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HHA22_RS01695	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HHA22_RS01700	COG0154	amidase activity
HHA22_RS01705	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HHA22_RS01710	COG1077	Cell shape determining protein MreB Mrl
HHA22_RS01715	COG1792	Involved in formation and maintenance of cell shape
HHA22_RS01725	COG0768	penicillin binding
HHA22_RS01730	COG0772	Belongs to the SEDS family
HHA22_RS01735	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HHA22_RS01740	COG0471	metal ion transport
HHA22_RS01745	COG1309	transcriptional regulator
HHA22_RS01755	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HHA22_RS01770	COG2823	Periplasmic or secreted lipoprotein
HHA22_RS01775	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HHA22_RS01780	COG0792	nuclease activity
HHA22_RS01800	COG1660	Displays ATPase and GTPase activities
HHA22_RS01815	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HHA22_RS01825	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HHA22_RS01830	COG1137	ATPase activity
HHA22_RS01845	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HHA22_RS01855	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HHA22_RS01870	COG1294	oxidase, subunit
HHA22_RS01880	COG4988	ABC transporter
HHA22_RS01885	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HHA22_RS01890	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HHA22_RS01905	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HHA22_RS01910	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HHA22_RS01915	COG1238	metal cluster binding
HHA22_RS01925	COG1802	Transcriptional regulator
HHA22_RS01935	COG1984	allophanate hydrolase subunit 2
HHA22_RS01940	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HHA22_RS01955	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HHA22_RS01970	COG2132	Multicopper oxidase
HHA22_RS01980	COG5002	protein histidine kinase activity
HHA22_RS01990	COG5002	protein histidine kinase activity
HHA22_RS01995	COG0745	RESPONSE REGULATOR receiver
HHA22_RS02000	COG2226	methyltransferase
HHA22_RS02015	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HHA22_RS02020	COG1028	Short-chain dehydrogenase reductase Sdr
HHA22_RS02055	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HHA22_RS02090	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HHA22_RS02105	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HHA22_RS02115	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HHA22_RS02120	COG1538	Outer membrane efflux protein
HHA22_RS02125	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HHA22_RS02130	COG0351	phosphomethylpyrimidine kinase
HHA22_RS02135	COG2022	thiamine diphosphate biosynthetic process
HHA22_RS02140	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HHA22_RS02145	COG4206	TonB-dependent receptor
HHA22_RS02155	COG2226	methyltransferase
HHA22_RS02170	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HHA22_RS02185	COG1194	a g-specific adenine glycosylase
HHA22_RS02195	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
HHA22_RS02200	COG2177	Part of the ABC transporter FtsEX involved in
HHA22_RS02205	COG2884	Cell division ATP-binding protein ftsE
HHA22_RS02210	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HHA22_RS02215	COG4597	amino acid ABC transporter
HHA22_RS02220	COG0765	amino acid transport
HHA22_RS02225	COG1126	abc transporter atp-binding protein
HHA22_RS02245	COG0477	Major facilitator Superfamily
HHA22_RS02255	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HHA22_RS02260	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HHA22_RS02275	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HHA22_RS02280	COG0237	dephospho-CoA kinase activity
HHA22_RS02285	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
HHA22_RS02310	COG3539	Fimbrial protein
HHA22_RS02315	COG2816	NAD+ diphosphatase activity
HHA22_RS02325	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HHA22_RS02360	COG0411	ABC transporter
HHA22_RS02395	COG1028	Short-chain dehydrogenase reductase Sdr
HHA22_RS02400	COG1024	Enoyl-CoA hydratase
HHA22_RS02430	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HHA22_RS02435	COG0352	thiamine-phosphate diphosphorylase activity
HHA22_RS02450	COG1678	Uncharacterized ACR, COG1678
HHA22_RS02455	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HHA22_RS02475	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HHA22_RS02485	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HHA22_RS02490	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HHA22_RS02500	COG0557	exoribonuclease II activity
HHA22_RS02505	COG3150	esterase
HHA22_RS02510	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HHA22_RS02515	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HHA22_RS02520	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HHA22_RS02525	COG0511	ligase activity, forming carbon-carbon bonds
HHA22_RS02530	COG0439	Biotin carboxylase
HHA22_RS02535	COG2264	protein methyltransferase activity
HHA22_RS02545	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HHA22_RS02565	COG1696	Membrane protein involved in D-alanine export
HHA22_RS02570	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HHA22_RS02600	COG1522	sequence-specific DNA binding
HHA22_RS02610	COG2814	Major facilitator Superfamily
HHA22_RS02615	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HHA22_RS02620	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HHA22_RS02620	COG1042	CoA-binding domain protein
HHA22_RS02620	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HHA22_RS02620	COG0045	succinate-CoA ligase (ADP-forming) activity
HHA22_RS02620	COG1042	CoA-binding domain protein
HHA22_RS02620	COG0045	succinate-CoA ligase (ADP-forming) activity
HHA22_RS02670	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HHA22_RS02695	COG3028	Belongs to the UPF0307 family
HHA22_RS02700	COG0312	modulator of DNA gyrase
HHA22_RS02710	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HHA22_RS02715	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HHA22_RS02720	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HHA22_RS02725	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HHA22_RS02735	COG0316	Belongs to the HesB IscA family
HHA22_RS02740	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HHA22_RS02750	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HHA22_RS02760	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HHA22_RS02765	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HHA22_RS02775	COG1335	isochorismatase
HHA22_RS02780	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HHA22_RS02780	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HHA22_RS02790	COG2766	serine protein kinase
HHA22_RS02795	COG2718	Belongs to the UPF0229 family
HHA22_RS02800	COG2719	SpoVR family
HHA22_RS02820	COG4948	Mandelate Racemase Muconate Lactonizing
HHA22_RS02845	COG3181	Tripartite tricarboxylate transporter family receptor
HHA22_RS02855	COG1063	alcohol dehydrogenase
HHA22_RS02880	COG2267	carboxylic ester hydrolase activity
HHA22_RS02885	COG1414	Transcriptional regulator
HHA22_RS02895	COG0477	Major facilitator Superfamily
HHA22_RS02905	COG0583	DNA-binding transcription factor activity
HHA22_RS02920	COG0179	Fumarylacetoacetate (FAA) hydrolase
HHA22_RS02925	COG0251	oxidation-reduction process
HHA22_RS02930	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HHA22_RS02935	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HHA22_RS02950	COG0165	Argininosuccinate lyase
HHA22_RS02960	COG3707	response regulator
HHA22_RS02970	COG0515	serine threonine protein kinase
HHA22_RS02975	COG2116	formate transmembrane transporter activity
HHA22_RS02985	COG2146	nitrite reductase [NAD(P)H] activity
HHA22_RS02985	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HHA22_RS02990	COG0589	response to stress
HHA22_RS03005	COG2816	NAD+ diphosphatase activity
HHA22_RS03010	COG1280	lysine exporter protein (LysE YggA)
HHA22_RS03050	COG2979	Protein of unknown function (DUF533)
HHA22_RS03060	COG0741	lytic transglycosylase activity
HHA22_RS03060	COG1388	LysM domain
HHA22_RS03065	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HHA22_RS03070	COG2226	methyltransferase
HHA22_RS03075	COG0328	RNA-DNA hybrid ribonuclease activity
HHA22_RS03085	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HHA22_RS03090	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HHA22_RS03100	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HHA22_RS03105	COG0842	Transport permease protein
HHA22_RS03105	COG1129	ABC transporter
HHA22_RS03110	COG0842	Transport permease protein
HHA22_RS03130	COG0463	Glycosyl transferase, family 2
HHA22_RS03135	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HHA22_RS03150	COG1073	alpha beta
HHA22_RS03160	COG0697	spore germination
HHA22_RS03165	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HHA22_RS03180	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HHA22_RS03190	COG1522	sequence-specific DNA binding
HHA22_RS03215	COG0823	Involved in the tonB-independent uptake of proteins
HHA22_RS03225	COG0848	biopolymer transport protein
HHA22_RS03230	COG0811	peptide transport
HHA22_RS03235	COG0824	Thioesterase
HHA22_RS03240	COG0442	prolyl-tRNA aminoacylation
HHA22_RS03270	COG1414	Transcriptional regulator
HHA22_RS03275	COG1024	Enoyl-CoA hydratase
HHA22_RS03290	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HHA22_RS03295	COG2084	Dehydrogenase
HHA22_RS03300	COG1028	Short-chain dehydrogenase reductase Sdr
HHA22_RS03305	COG1309	transcriptional regulator
HHA22_RS03340	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HHA22_RS03345	COG4654	Cytochrome c, class I
HHA22_RS03350	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HHA22_RS03400	COG1473	amidohydrolase
HHA22_RS03405	COG0418	dihydroorotase activity
HHA22_RS03410	COG0488	(ABC) transporter
HHA22_RS03420	COG2001	Belongs to the MraZ family
HHA22_RS03425	COG0275	rRNA processing
HHA22_RS03430	COG3116	cell division
HHA22_RS03440	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HHA22_RS03445	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HHA22_RS03450	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HHA22_RS03460	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HHA22_RS03465	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HHA22_RS03470	COG1181	Belongs to the D-alanine--D-alanine ligase family
HHA22_RS03475	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HHA22_RS03490	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HHA22_RS03505	COG0739	heme binding
HHA22_RS03510	COG0653	protein targeting
HHA22_RS03535	COG1522	sequence-specific DNA binding
HHA22_RS03550	COG2239	Acts as a magnesium transporter
HHA22_RS03560	COG2855	membrane
HHA22_RS03565	COG0583	DNA-binding transcription factor activity
HHA22_RS03570	COG1473	amidohydrolase
HHA22_RS03575	COG0318	PFAM AMP-dependent synthetase and ligase
HHA22_RS03585	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HHA22_RS03585	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HHA22_RS03590	COG1501	Belongs to the glycosyl hydrolase 31 family
HHA22_RS03595	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HHA22_RS03600	COG2011	ABC-type metal ion transport system permease component
HHA22_RS03645	COG0463	Glycosyl transferase, family 2
HHA22_RS03650	COG0463	Glycosyl transferase, family 2
HHA22_RS03670	COG1051	belongs to the nudix hydrolase family
HHA22_RS03715	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HHA22_RS03720	COG0156	8-amino-7-oxononanoate synthase activity
HHA22_RS03725	COG3321	synthase
HHA22_RS03725	COG0604	alcohol dehydrogenase
HHA22_RS03725	COG1028	Short-chain dehydrogenase reductase Sdr
HHA22_RS03730	COG0402	S-adenosylhomocysteine deaminase activity
HHA22_RS03755	COG0727	PFAM Uncharacterised protein family (UPF0153)
HHA22_RS03760	COG2818	Glycosylase
HHA22_RS03765	COG2982	Protein involved in outer membrane biogenesis
HHA22_RS03795	COG0559	Belongs to the binding-protein-dependent transport system permease family
HHA22_RS03810	COG0410	ABC transporter
HHA22_RS03830	COG0583	DNA-binding transcription factor activity
HHA22_RS03835	COG0737	Belongs to the 5'-nucleotidase family
HHA22_RS03845	COG4106	trans-aconitate 2-methyltransferase activity
HHA22_RS03850	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HHA22_RS03860	COG0667	Aldo Keto reductase
HHA22_RS03875	COG2154	pterin-4-alpha-carbinolamine dehydratase
HHA22_RS03885	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HHA22_RS03895	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HHA22_RS03900	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HHA22_RS03905	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HHA22_RS03915	COG1929	Belongs to the glycerate kinase type-1 family
HHA22_RS03920	COG0469	pyruvate kinase activity
HHA22_RS03925	COG0700	Nucleoside recognition
HHA22_RS03930	COG1960	acyl-CoA dehydrogenase activity
HHA22_RS03935	COG0242	peptide deformylase activity
HHA22_RS03955	COG1053	succinate dehydrogenase
HHA22_RS03955	COG3976	FMN-binding domain protein
HHA22_RS03960	COG0583	DNA-binding transcription factor activity
HHA22_RS03970	COG0204	Acyl-transferase
HHA22_RS03975	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HHA22_RS03980	COG0751	glycine-tRNA ligase activity
HHA22_RS03985	COG0752	glycyl-tRNA synthetase alpha subunit
HHA22_RS03990	COG1024	Enoyl-CoA hydratase
HHA22_RS04000	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
HHA22_RS04030	COG0617	tRNA 3'-terminal CCA addition
HHA22_RS04045	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HHA22_RS04050	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HHA22_RS04055	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HHA22_RS04060	COG0586	Pfam SNARE associated Golgi protein
HHA22_RS04065	COG3064	Membrane
HHA22_RS04065	COG3210	domain, Protein
HHA22_RS04065	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
HHA22_RS04065	COG3064	Membrane
HHA22_RS04065	COG3210	domain, Protein
HHA22_RS04065	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
HHA22_RS04070	COG0860	N-Acetylmuramoyl-L-alanine amidase
HHA22_RS04080	COG0114	fumarate hydratase activity
HHA22_RS04090	COG3181	Tripartite tricarboxylate transporter family receptor
HHA22_RS04110	COG3210	domain, Protein
HHA22_RS04120	COG0579	oxidoreductase
HHA22_RS04125	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HHA22_RS04130	COG0259	pyridoxamine-phosphate oxidase activity
HHA22_RS04145	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HHA22_RS04150	COG0577	efflux transmembrane transporter activity
HHA22_RS04150	COG1136	(ABC) transporter
HHA22_RS04155	COG1538	Outer membrane efflux protein
HHA22_RS04160	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HHA22_RS04170	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HHA22_RS04195	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HHA22_RS04220	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HHA22_RS04240	COG1028	Short-chain dehydrogenase reductase Sdr
HHA22_RS04285	COG0583	DNA-binding transcription factor activity
HHA22_RS04310	COG0427	acetyl-CoA hydrolase
HHA22_RS04315	COG1960	acyl-CoA dehydrogenase activity
HHA22_RS04320	COG2301	Belongs to the HpcH HpaI aldolase family
HHA22_RS04350	COG0559	Belongs to the binding-protein-dependent transport system permease family
HHA22_RS04355	COG0683	leucine binding
HHA22_RS04365	COG2205	protein histidine kinase activity
HHA22_RS04370	COG3210	domain, Protein
HHA22_RS04380	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HHA22_RS04385	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HHA22_RS04390	COG1538	Outer membrane efflux protein
HHA22_RS04410	COG3258	Cytochrome c
HHA22_RS04415	COG2863	cytochrome
HHA22_RS04435	COG2205	protein histidine kinase activity
HHA22_RS04450	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HHA22_RS04455	COG2301	Belongs to the HpcH HpaI aldolase family
HHA22_RS04470	COG3181	Tripartite tricarboxylate transporter family receptor
HHA22_RS04480	COG2814	Major facilitator Superfamily
HHA22_RS04495	COG3181	Tripartite tricarboxylate transporter family receptor
HHA22_RS04500	COG4948	Mandelate Racemase Muconate Lactonizing
HHA22_RS04505	COG0583	DNA-binding transcription factor activity
HHA22_RS04550	COG3585	molybdate ion transport
HHA22_RS04555	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HHA22_RS04565	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HHA22_RS04570	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HHA22_RS04585	COG2188	Transcriptional regulator
HHA22_RS04590	COG0179	Fumarylacetoacetate (FAA) hydrolase
HHA22_RS04600	COG0402	S-adenosylhomocysteine deaminase activity
HHA22_RS04605	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HHA22_RS04610	COG0022	dehydrogenase e1 component
HHA22_RS04610	COG0508	dehydrogenase complex catalyzes the overall conversion of
HHA22_RS04615	COG1024	Enoyl-CoA hydratase
HHA22_RS04620	COG0508	dehydrogenase complex catalyzes the overall conversion of
HHA22_RS04630	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HHA22_RS04660	COG1028	Short-chain dehydrogenase reductase Sdr
HHA22_RS04665	COG0411	ABC transporter
HHA22_RS04690	COG1309	transcriptional regulator
HHA22_RS04705	COG1024	Enoyl-CoA hydratase
HHA22_RS04730	COG0154	amidase activity
HHA22_RS04740	COG0583	DNA-binding transcription factor activity
HHA22_RS04755	COG2197	response regulator
HHA22_RS04760	COG2814	Major facilitator Superfamily
HHA22_RS04770	COG4774	siderophore transport
HHA22_RS04775	COG3712	iron ion homeostasis
HHA22_RS04780	COG1595	DNA-templated transcription, initiation
HHA22_RS04815	COG0625	glutathione transferase activity
HHA22_RS04825	COG0747	negative chemotaxis
HHA22_RS04830	COG0583	DNA-binding transcription factor activity
HHA22_RS04865	COG0444	Belongs to the ABC transporter superfamily
HHA22_RS04870	COG4608	Belongs to the ABC transporter superfamily
HHA22_RS04875	COG2207	Transcriptional regulator
HHA22_RS04880	COG1028	Short-chain dehydrogenase reductase Sdr
HHA22_RS04895	COG1012	belongs to the aldehyde dehydrogenase family
HHA22_RS04900	COG3284	Transcriptional regulator
HHA22_RS04910	COG2814	Major facilitator Superfamily
HHA22_RS04915	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HHA22_RS04925	COG1959	2 iron, 2 sulfur cluster binding
HHA22_RS04935	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HHA22_RS04945	COG1971	Probably functions as a manganese efflux pump
HHA22_RS04960	COG1360	Flagellar Motor Protein
HHA22_RS04995	COG5265	(ABC) transporter
HHA22_RS05010	COG0833	amino acid
HHA22_RS05040	COG0235	Class ii aldolase
HHA22_RS05050	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HHA22_RS05055	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HHA22_RS05060	COG2186	Transcriptional regulator
HHA22_RS05065	COG1024	Enoyl-CoA hydratase
HHA22_RS05080	COG0583	DNA-binding transcription factor activity
HHA22_RS05090	COG2159	amidohydrolase
HHA22_RS05105	COG1301	dicarboxylic acid transport
HHA22_RS05115	COG0148	phosphopyruvate hydratase activity
HHA22_RS05125	COG2814	Major facilitator Superfamily
HHA22_RS05130	COG0583	DNA-binding transcription factor activity
HHA22_RS05175	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HHA22_RS05185	COG4774	siderophore transport
HHA22_RS05195	COG3128	pkhd-type hydroxylase
HHA22_RS05210	COG3064	Membrane
HHA22_RS05215	COG1408	metallophosphoesterase
HHA22_RS05225	COG0456	acetyltransferase
HHA22_RS05235	COG2610	gluconate transmembrane transporter activity
HHA22_RS05245	COG2070	2-Nitropropane dioxygenase
HHA22_RS05255	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HHA22_RS05300	COG1846	Transcriptional regulator
HHA22_RS05315	COG3300	MHYT domain
HHA22_RS05315	COG5001	Diguanylate cyclase
HHA22_RS05340	COG4964	Belongs to the GSP D family
HHA22_RS05395	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HHA22_RS05400	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HHA22_RS05415	COG3384	dioxygenase
HHA22_RS05420	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HHA22_RS05440	COG2176	DNA-directed DNA polymerase activity
HHA22_RS05465	COG4221	oxidoreductase activity
HHA22_RS05475	COG1511	domain protein
HHA22_RS05475	COG3264	Mechanosensitive ion channel
HHA22_RS05480	COG0583	DNA-binding transcription factor activity
HHA22_RS05485	COG0427	acetyl-CoA hydrolase
HHA22_RS05490	COG0583	DNA-binding transcription factor activity
HHA22_RS05550	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HHA22_RS05565	COG0154	amidase activity
HHA22_RS05580	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HHA22_RS05595	COG0495	leucyl-tRNA aminoacylation
HHA22_RS05600	COG2814	Major facilitator Superfamily
HHA22_RS05605	COG1846	Transcriptional regulator
HHA22_RS05625	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HHA22_RS05630	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HHA22_RS05635	COG2814	Major facilitator Superfamily
HHA22_RS05640	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HHA22_RS05650	COG4176	ABC-type proline glycine betaine transport system permease component
HHA22_RS05665	COG0183	Belongs to the thiolase family
HHA22_RS05685	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HHA22_RS05685	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HHA22_RS05695	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HHA22_RS05700	COG1845	cytochrome c oxidase, subunit III
HHA22_RS05705	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HHA22_RS05710	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HHA22_RS05715	COG0477	Major facilitator Superfamily
HHA22_RS05720	COG0428	transporter
HHA22_RS05725	COG0412	Dienelactone hydrolase
HHA22_RS05730	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HHA22_RS05735	COG1283	sodium-dependent phosphate transmembrane transporter activity
HHA22_RS05740	COG1760	l-serine dehydratase
HHA22_RS05745	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HHA22_RS05760	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HHA22_RS05785	COG2311	Membrane
HHA22_RS05795	COG2358	TRAP transporter, solute receptor (TAXI family
HHA22_RS05800	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HHA22_RS05815	COG0456	acetyltransferase
HHA22_RS05825	COG0662	Cupin 2, conserved barrel domain protein
HHA22_RS05830	COG5285	phytanoyl-CoA dioxygenase
HHA22_RS05835	COG3217	Mosc domain protein beta barrel domain protein
HHA22_RS05835	COG0633	Ferredoxin
HHA22_RS05840	COG2076	Multidrug Resistance protein
HHA22_RS05845	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HHA22_RS05850	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HHA22_RS05850	COG0543	2 iron, 2 sulfur cluster binding
HHA22_RS05855	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HHA22_RS05905	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HHA22_RS05910	COG0425	Belongs to the sulfur carrier protein TusA family
HHA22_RS05920	COG0228	four-way junction DNA binding
HHA22_RS05925	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HHA22_RS05930	COG0336	Belongs to the RNA methyltransferase TrmD family
HHA22_RS05935	COG0525	valine-tRNA ligase activity
HHA22_RS05940	COG0105	UTP biosynthetic process
HHA22_RS05945	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HHA22_RS05960	COG0124	histidyl-tRNA synthetase
HHA22_RS05965	COG2976	Protein conserved in bacteria
HHA22_RS05970	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HHA22_RS05975	COG1160	GTP binding
HHA22_RS05985	COG1923	regulation of RNA biosynthetic process
HHA22_RS05990	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HHA22_RS05995	COG0330	HflC and HflK could
HHA22_RS06000	COG0330	HflC and HflK could
HHA22_RS06005	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HHA22_RS06010	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HHA22_RS06020	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HHA22_RS06070	COG2207	Transcriptional regulator
HHA22_RS06100	COG0330	HflC and HflK could
HHA22_RS06165	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
HHA22_RS06200	COG0583	DNA-binding transcription factor activity
HHA22_RS06215	COG2084	Dehydrogenase
HHA22_RS06225	COG1597	lipid kinase activity
HHA22_RS06225	COG1803	Methylglyoxal synthase
HHA22_RS06235	COG0671	phosphoesterase, PA-phosphatase related
HHA22_RS06255	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HHA22_RS06260	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HHA22_RS06265	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HHA22_RS06270	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HHA22_RS06275	COG0649	NAD binding
HHA22_RS06280	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
HHA22_RS06290	COG1034	ATP synthesis coupled electron transport
HHA22_RS06295	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HHA22_RS06300	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HHA22_RS06310	COG0713	ATP synthesis coupled electron transport
HHA22_RS06325	COG1007	ATP synthesis coupled electron transport
HHA22_RS06335	COG0560	Phosphoserine phosphatase
HHA22_RS06340	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HHA22_RS06345	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HHA22_RS06350	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HHA22_RS06355	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HHA22_RS06360	COG0450	alkyl hydroperoxide reductase
HHA22_RS06375	COG1214	PFAM Peptidase M22, glycoprotease
HHA22_RS06380	COG1573	uracil-dna glycosylase
HHA22_RS06385	COG0477	Major facilitator Superfamily
HHA22_RS06390	COG1196	nuclear chromosome segregation
HHA22_RS06400	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HHA22_RS06410	COG0765	amino acid transport
HHA22_RS06415	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HHA22_RS06425	COG0625	glutathione transferase activity
HHA22_RS06430	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HHA22_RS06435	COG0271	Belongs to the BolA IbaG family
HHA22_RS06440	COG2917	probably involved in intracellular septation
HHA22_RS06445	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HHA22_RS06450	COG1122	ATPase activity
HHA22_RS06455	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HHA22_RS06460	COG1268	BioY protein
HHA22_RS06490	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HHA22_RS06520	COG0411	ABC transporter
HHA22_RS06525	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HHA22_RS06530	COG2878	Part of a membrane complex involved in electron transport
HHA22_RS06555	COG0251	oxidation-reduction process
HHA22_RS06565	COG3228	Belongs to the MtfA family
HHA22_RS06570	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HHA22_RS06590	COG0159	tryptophan synthase activity
HHA22_RS06595	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HHA22_RS06600	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HHA22_RS06605	COG1530	ribonuclease E activity
HHA22_RS06610	COG0564	pseudouridine synthase activity
HHA22_RS06615	COG0546	phosphoglycolate phosphatase activity
HHA22_RS06620	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HHA22_RS06625	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
HHA22_RS06630	COG3023	N-Acetylmuramoyl-L-alanine amidase
HHA22_RS06640	COG0424	maF-like protein
HHA22_RS06645	COG1399	metal-binding, possibly nucleic acid-binding protein
HHA22_RS06650	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HHA22_RS06660	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HHA22_RS06670	COG1028	Short-chain dehydrogenase reductase Sdr
HHA22_RS06675	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HHA22_RS06680	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HHA22_RS06700	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HHA22_RS06705	COG0481	GTPase activity
HHA22_RS06710	COG0681	Belongs to the peptidase S26 family
HHA22_RS06715	COG0571	ribonuclease III activity
HHA22_RS06720	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HHA22_RS06725	COG1381	Involved in DNA repair and RecF pathway recombination
HHA22_RS06745	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HHA22_RS06755	COG0583	DNA-binding transcription factor activity
HHA22_RS06770	COG0583	DNA-binding transcription factor activity
HHA22_RS06780	COG0791	NLP P60 protein
HHA22_RS06785	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HHA22_RS06790	COG3193	protein, possibly involved in utilization of glycolate and propanediol
HHA22_RS06800	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HHA22_RS06805	COG0697	spore germination
HHA22_RS06810	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HHA22_RS06850	COG1446	asparaginase
HHA22_RS06855	COG4172	Belongs to the ABC transporter superfamily
HHA22_RS06860	COG0747	negative chemotaxis
HHA22_RS06865	COG0601	transmembrane transport
HHA22_RS06870	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HHA22_RS06890	COG0504	CTP synthase activity
HHA22_RS06900	COG0148	phosphopyruvate hydratase activity
HHA22_RS06915	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HHA22_RS06925	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HHA22_RS06930	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HHA22_RS06950	COG1981	membrane
HHA22_RS06970	COG0039	L-malate dehydrogenase activity
HHA22_RS06975	COG2188	Transcriptional regulator
HHA22_RS06980	COG2009	succinate dehydrogenase
HHA22_RS06985	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HHA22_RS06990	COG1053	succinate dehydrogenase
HHA22_RS06995	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HHA22_RS07000	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HHA22_RS07005	COG0372	Belongs to the citrate synthase family
HHA22_RS07010	COG0583	DNA-binding transcription factor activity
HHA22_RS07015	COG3842	ATPase activity
HHA22_RS07025	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HHA22_RS07030	COG1840	ABC-type Fe3 transport system, periplasmic component
HHA22_RS07055	COG3128	pkhd-type hydroxylase
HHA22_RS07060	COG4774	siderophore transport
HHA22_RS07065	COG0280	phosphate acetyltransferase
HHA22_RS07065	COG0281	malic enzyme
HHA22_RS07075	COG1297	OPT oligopeptide transporter protein
HHA22_RS07080	COG0567	Dehydrogenase, E1 component
HHA22_RS07085	COG0508	dehydrogenase complex catalyzes the overall conversion of
HHA22_RS07090	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HHA22_RS07095	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HHA22_RS07120	COG2183	response to ionizing radiation
HHA22_RS07125	COG1199	ATP-dependent helicase activity
HHA22_RS07165	COG0564	pseudouridine synthase activity
HHA22_RS07175	COG3243	poly(R)-hydroxyalkanoic acid synthase
HHA22_RS07180	COG1028	Short-chain dehydrogenase reductase Sdr
HHA22_RS07185	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
HHA22_RS07200	COG0672	)-iron permease
HHA22_RS07215	COG2823	Periplasmic or secreted lipoprotein
HHA22_RS07225	COG3237	CsbD-like
HHA22_RS07230	COG3038	cytochrome b561
HHA22_RS07235	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HHA22_RS07235	COG0189	ligase activity
HHA22_RS07240	COG0189	ligase activity
HHA22_RS07240	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HHA22_RS07245	COG1132	(ABC) transporter
HHA22_RS07255	COG0297	glycogen (starch) synthase activity
HHA22_RS07260	COG2833	Protein of unknown function (DUF455)
HHA22_RS07265	COG2951	lytic endotransglycosylase activity
HHA22_RS07275	COG0589	response to stress
HHA22_RS07285	COG3706	GGDEF domain
HHA22_RS07320	COG3181	Tripartite tricarboxylate transporter family receptor
HHA22_RS07350	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HHA22_RS07365	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HHA22_RS07370	COG1605	Chorismate mutase
HHA22_RS07370	COG0077	Prephenate dehydratase
HHA22_RS07375	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HHA22_RS07380	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HHA22_RS07385	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HHA22_RS07390	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HHA22_RS07410	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HHA22_RS07415	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HHA22_RS07420	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HHA22_RS07425	COG0587	DNA-directed DNA polymerase activity
HHA22_RS07435	COG2951	lytic endotransglycosylase activity
HHA22_RS07440	COG0123	including yeast histone deacetylase and acetoin utilization protein
HHA22_RS07455	COG2985	domain, Protein
HHA22_RS07460	COG1960	acyl-CoA dehydrogenase activity
HHA22_RS07465	COG0450	alkyl hydroperoxide reductase
HHA22_RS07470	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HHA22_RS07475	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HHA22_RS07480	COG4208	sulfate ABC transporter
HHA22_RS07485	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HHA22_RS07490	COG0175	sulfate reduction
HHA22_RS07500	COG2895	sulfate adenylyltransferase (ATP) activity
HHA22_RS07520	COG0335	large ribosomal subunit rRNA binding
HHA22_RS07525	COG0494	nUDIX hydrolase
HHA22_RS07530	COG3622	Belongs to the hyi family
HHA22_RS07535	COG1162	GTPase activity
HHA22_RS07540	COG0501	Belongs to the peptidase M48B family
HHA22_RS07545	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HHA22_RS07550	COG1335	isochorismatase
HHA22_RS07560	COG0583	DNA-binding transcription factor activity
HHA22_RS07575	COG3396	Phenylacetate-CoA oxygenase
HHA22_RS07580	COG3460	Phenylacetate-CoA oxygenase
HHA22_RS07585	COG3396	Phenylacetate-CoA oxygenase
HHA22_RS07590	COG2151	metal-sulfur cluster biosynthetic enzyme
HHA22_RS07595	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HHA22_RS07600	COG1012	belongs to the aldehyde dehydrogenase family
HHA22_RS07605	COG1024	Enoyl-CoA hydratase
HHA22_RS07610	COG2050	protein possibly involved in aromatic compounds catabolism
HHA22_RS07630	COG1126	abc transporter atp-binding protein
HHA22_RS07655	COG2198	Histidine kinase
HHA22_RS07655	COG5002	protein histidine kinase activity
HHA22_RS07655	COG0784	Response regulator, receiver
HHA22_RS07660	COG3437	response regulator, receiver
HHA22_RS07675	COG1802	Transcriptional regulator
HHA22_RS07680	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HHA22_RS07680	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HHA22_RS07690	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HHA22_RS07695	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HHA22_RS07705	COG3642	lipopolysaccharide core region biosynthetic process
HHA22_RS07715	COG3842	ATPase activity
HHA22_RS07720	COG1176	ABC-type spermidine putrescine transport system, permease component I
HHA22_RS07725	COG1177	transmembrane transport
HHA22_RS07730	COG1393	Belongs to the ArsC family
HHA22_RS07735	COG2094	Belongs to the DNA glycosylase MPG family
HHA22_RS07745	COG1322	Protein conserved in bacteria
HHA22_RS07750	COG1960	acyl-CoA dehydrogenase activity
HHA22_RS07755	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HHA22_RS07760	COG0704	Plays a role in the regulation of phosphate uptake
HHA22_RS07765	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
HHA22_RS07770	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HHA22_RS07770	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HHA22_RS07775	COG1643	Atp-dependent helicase
HHA22_RS07790	COG0438	transferase activity, transferring glycosyl groups
HHA22_RS07795	COG0726	polysaccharide deacetylase
HHA22_RS07835	COG1132	(ABC) transporter
HHA22_RS07850	COG1530	ribonuclease E activity
HHA22_RS07880	COG0583	DNA-binding transcription factor activity
HHA22_RS07890	COG0477	Major facilitator Superfamily
HHA22_RS07895	COG0500	methyltransferase
HHA22_RS07900	COG1418	mRNA catabolic process
HHA22_RS07925	COG2204	response regulator
HHA22_RS07930	COG4191	Histidine kinase
HHA22_RS07935	COG1301	dicarboxylic acid transport
HHA22_RS07940	COG0424	maF-like protein
HHA22_RS07945	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HHA22_RS07950	COG0799	negative regulation of ribosome biogenesis
HHA22_RS07955	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HHA22_RS07965	COG0151	Belongs to the GarS family
HHA22_RS07970	COG0217	transcriptional regulatory protein
HHA22_RS07975	COG0433	COG0433 Predicted ATPase
HHA22_RS07985	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HHA22_RS07990	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HHA22_RS07995	COG1012	belongs to the aldehyde dehydrogenase family
HHA22_RS08020	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HHA22_RS08025	COG4172	Belongs to the ABC transporter superfamily
HHA22_RS08030	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HHA22_RS08035	COG0601	transmembrane transport
HHA22_RS08040	COG0747	negative chemotaxis
HHA22_RS08050	COG0473	3-isopropylmalate dehydrogenase activity
HHA22_RS08055	COG2814	Major facilitator Superfamily
HHA22_RS08060	COG1566	PFAM secretion protein HlyD family protein
HHA22_RS08070	COG1846	Transcriptional regulator
HHA22_RS08090	COG0501	Belongs to the peptidase M48B family
HHA22_RS08130	COG1722	exodeoxyribonuclease VII activity
HHA22_RS08135	COG0142	geranyltranstransferase activity
HHA22_RS08140	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HHA22_RS08145	COG1469	GTP cyclohydrolase I activity
HHA22_RS08150	COG0360	Binds together with S18 to 16S ribosomal RNA
HHA22_RS08155	COG2965	DNA replication, synthesis of RNA primer
HHA22_RS08160	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HHA22_RS08165	COG0359	binds to the 23S rRNA
HHA22_RS08175	COG0305	Participates in initiation and elongation during chromosome replication
HHA22_RS08185	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HHA22_RS08190	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HHA22_RS08195	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HHA22_RS08200	COG3737	Protein of unknown function (DUF498/DUF598)
HHA22_RS08205	COG0436	Aminotransferase
HHA22_RS08225	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HHA22_RS08230	COG0308	aminopeptidase N
HHA22_RS08245	COG0312	modulator of DNA gyrase
HHA22_RS08250	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HHA22_RS08255	COG0277	FAD linked oxidase domain protein
HHA22_RS08260	COG0277	FAD linked oxidase domain protein
HHA22_RS08265	COG0277	FAD linked oxidase domain protein
HHA22_RS08270	COG0247	lactate metabolic process
HHA22_RS08295	COG3181	Tripartite tricarboxylate transporter family receptor
HHA22_RS08300	COG0583	DNA-binding transcription factor activity
HHA22_RS08305	COG0482	sulfurtransferase activity
HHA22_RS08310	COG0730	response to heat
HHA22_RS08315	COG0625	glutathione transferase activity
HHA22_RS08325	COG3909	cytochrome
HHA22_RS08355	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HHA22_RS08375	COG3706	GGDEF domain
HHA22_RS08380	COG3706	GGDEF domain
HHA22_RS08400	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HHA22_RS08405	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
HHA22_RS08415	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HHA22_RS08420	COG0069	glutamate synthase activity
HHA22_RS08425	COG2391	methyltransferase activity
HHA22_RS08430	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HHA22_RS08435	COG0679	Auxin Efflux Carrier
HHA22_RS08465	COG0557	exoribonuclease II activity
HHA22_RS08470	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HHA22_RS08480	COG0776	regulation of translation
HHA22_RS08510	COG0642	Histidine kinase
HHA22_RS08515	COG3158	transport of potassium into the cell
HHA22_RS08525	COG0137	argininosuccinate synthase activity
HHA22_RS08530	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HHA22_RS08535	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HHA22_RS08545	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HHA22_RS08550	COG3181	Tripartite tricarboxylate transporter family receptor
HHA22_RS08560	COG2186	Transcriptional regulator
HHA22_RS08580	COG3836	Belongs to the HpcH HpaI aldolase family
HHA22_RS08585	COG0268	Binds directly to 16S ribosomal RNA
HHA22_RS08610	COG0728	peptidoglycan biosynthetic process
HHA22_RS08620	COG0563	adenylate kinase activity
HHA22_RS08625	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HHA22_RS08630	COG2835	tetraacyldisaccharide 4'-kinase activity
HHA22_RS08635	COG1663	tetraacyldisaccharide 4'-kinase activity
HHA22_RS08645	COG0811	peptide transport
HHA22_RS08650	COG1570	exodeoxyribonuclease VII activity
HHA22_RS08655	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HHA22_RS08660	COG0038	chloride channel
HHA22_RS08665	COG0183	Belongs to the thiolase family
HHA22_RS08675	COG1278	Cold shock
HHA22_RS08680	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HHA22_RS08690	COG4953	penicillin-binding protein 1C
HHA22_RS08695	COG0542	response to heat
HHA22_RS08700	COG2995	paraquat-inducible protein a
HHA22_RS08705	COG3008	intermembrane lipid transfer
HHA22_RS08715	COG0506	proline dehydrogenase activity
HHA22_RS08715	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HHA22_RS08715	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HHA22_RS08745	COG2271	Major facilitator Superfamily
HHA22_RS08755	COG0004	ammonium transporteR
HHA22_RS08760	COG0347	Belongs to the P(II) protein family
HHA22_RS08775	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HHA22_RS08780	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HHA22_RS08785	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HHA22_RS08790	COG0072	phenylalanine-tRNA ligase activity
HHA22_RS08790	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HHA22_RS08795	COG0776	regulation of translation
HHA22_RS08830	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HHA22_RS08855	COG1522	sequence-specific DNA binding
HHA22_RS08900	COG5265	(ABC) transporter
HHA22_RS08905	COG0656	L-ascorbic acid biosynthetic process
HHA22_RS08910	COG0667	Aldo Keto reductase
HHA22_RS08925	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HHA22_RS08950	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HHA22_RS08970	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HHA22_RS08975	COG3246	L-lysine catabolic process to acetate
HHA22_RS08980	COG1250	3-hydroxyacyl-CoA dehydrogenase
HHA22_RS08985	COG0583	DNA-binding transcription factor activity
HHA22_RS08995	COG0129	dihydroxy-acid dehydratase activity
HHA22_RS09000	COG3181	Tripartite tricarboxylate transporter family receptor
HHA22_RS09045	COG0154	amidase activity
HHA22_RS09050	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HHA22_RS09080	COG2267	carboxylic ester hydrolase activity
HHA22_RS09085	COG0501	Belongs to the peptidase M48B family
HHA22_RS09095	COG0789	Transcriptional regulator
HHA22_RS09100	COG0778	Nitroreductase
HHA22_RS09105	COG0165	Argininosuccinate lyase
HHA22_RS09110	COG0668	transmembrane transport
HHA22_RS09115	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HHA22_RS09115	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HHA22_RS09130	COG0583	DNA-binding transcription factor activity
HHA22_RS09140	COG0747	negative chemotaxis
HHA22_RS09145	COG0601	transmembrane transport
HHA22_RS09150	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HHA22_RS09155	COG4172	Belongs to the ABC transporter superfamily
HHA22_RS09165	COG1280	lysine exporter protein (LysE YggA)
HHA22_RS09175	COG3161	chorismate lyase activity
HHA22_RS09180	COG1187	pseudouridine synthase activity
HHA22_RS09190	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HHA22_RS09215	COG1999	signal sequence binding
HHA22_RS09225	COG0339	signal peptide processing
HHA22_RS09230	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HHA22_RS09235	COG4566	intracellular signal transduction
HHA22_RS09245	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HHA22_RS09250	COG0508	dehydrogenase complex catalyzes the overall conversion of
HHA22_RS09255	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HHA22_RS09265	COG4797	methyltransferase
HHA22_RS09265	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HHA22_RS09300	COG0745	RESPONSE REGULATOR receiver
HHA22_RS09315	COG0840	transmembrane signaling receptor activity
HHA22_RS09320	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HHA22_RS09325	COG2201	protein-glutamate methylesterase activity
HHA22_RS09330	COG0745	RESPONSE REGULATOR receiver
HHA22_RS09335	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
HHA22_RS09340	COG0840	transmembrane signaling receptor activity
HHA22_RS09345	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HHA22_RS09365	COG2747	anti-sigma28 factor FlgM
HHA22_RS09390	COG1749	Flagellar hook protein flgE
HHA22_RS09410	COG1706	bacterial-type flagellum-dependent cell motility
HHA22_RS09420	COG1256	bacterial-type flagellum assembly
HHA22_RS09430	COG0840	transmembrane signaling receptor activity
HHA22_RS09435	COG0840	transmembrane signaling receptor activity
HHA22_RS09445	COG0840	transmembrane signaling receptor activity
HHA22_RS09450	COG0840	transmembrane signaling receptor activity
HHA22_RS09475	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HHA22_RS09485	COG1580	Controls the rotational direction of flagella during chemotaxis
HHA22_RS09495	COG2882	bacterial-type flagellum organization
HHA22_RS09505	COG1317	bacterial-type flagellum organization
HHA22_RS09510	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HHA22_RS09515	COG1766	The M ring may be actively involved in energy transduction
HHA22_RS09520	COG1677	Flagellar hook-basal body complex protein FliE
HHA22_RS09530	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HHA22_RS09550	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HHA22_RS09570	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HHA22_RS09575	COG3181	Tripartite tricarboxylate transporter family receptor
HHA22_RS09585	COG0285	dihydrofolate synthase activity
HHA22_RS09595	COG1286	toxin biosynthetic process
HHA22_RS09615	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HHA22_RS09620	COG0024	Methionine aminopeptidase
HHA22_RS09625	COG0052	Belongs to the universal ribosomal protein uS2 family
HHA22_RS09630	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HHA22_RS09635	COG0528	UMP kinase activity
HHA22_RS09640	COG0233	cytoplasmic translational termination
HHA22_RS09645	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HHA22_RS09650	COG0575	Belongs to the CDS family
HHA22_RS09655	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HHA22_RS09660	COG0750	zinc metalloprotease
HHA22_RS09665	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HHA22_RS09675	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HHA22_RS09680	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HHA22_RS09690	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HHA22_RS09695	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HHA22_RS09700	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HHA22_RS09710	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HHA22_RS09735	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HHA22_RS09745	COG2914	Belongs to the UPF0125 (RnfH) family
HHA22_RS09750	COG1960	acyl-CoA dehydrogenase activity
HHA22_RS09755	COG1024	Enoyl-CoA hydratase
HHA22_RS09755	COG1250	3-hydroxyacyl-CoA dehydrogenase
HHA22_RS09775	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HHA22_RS09780	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HHA22_RS09790	COG0084	hydrolase, TatD family'
HHA22_RS09805	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HHA22_RS09810	COG0765	amino acid transport
HHA22_RS09815	COG1126	abc transporter atp-binding protein
HHA22_RS09820	COG0010	Belongs to the arginase family
HHA22_RS09840	COG4221	oxidoreductase activity
HHA22_RS09845	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HHA22_RS09855	COG2059	Chromate
HHA22_RS09860	COG0640	Transcriptional regulator
HHA22_RS09870	COG0740	serine-type endopeptidase activity
HHA22_RS09880	COG0095	Lipoate-protein ligase
HHA22_RS09905	COG0386	Belongs to the glutathione peroxidase family
HHA22_RS09930	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HHA22_RS09975	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HHA22_RS09980	COG2259	Doxx family
HHA22_RS10000	COG1028	Short-chain dehydrogenase reductase Sdr
HHA22_RS10010	COG0842	Transport permease protein
HHA22_RS10015	COG1129	ABC transporter
HHA22_RS10015	COG0842	Transport permease protein
HHA22_RS10020	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HHA22_RS10030	COG3243	poly(R)-hydroxyalkanoic acid synthase
HHA22_RS10050	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HHA22_RS10080	COG2733	membrane
HHA22_RS10090	COG3042	response to heat
HHA22_RS10095	COG3258	Cytochrome c
HHA22_RS10125	COG3958	Transketolase
HHA22_RS10130	COG3959	Transketolase, thiamine diphosphate binding domain
HHA22_RS10140	COG1802	Transcriptional regulator
HHA22_RS10190	COG0583	DNA-binding transcription factor activity
HHA22_RS10195	COG0028	Belongs to the TPP enzyme family
HHA22_RS10200	COG0477	Major facilitator Superfamily
HHA22_RS10205	COG0583	DNA-binding transcription factor activity
HHA22_RS10210	COG3181	Tripartite tricarboxylate transporter family receptor
HHA22_RS10215	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HHA22_RS10225	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HHA22_RS10245	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HHA22_RS10245	COG0519	Catalyzes the synthesis of GMP from XMP
HHA22_RS10260	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HHA22_RS10275	COG1024	Enoyl-CoA hydratase
HHA22_RS10290	COG1960	acyl-CoA dehydrogenase activity
HHA22_RS10295	COG1960	acyl-CoA dehydrogenase activity
HHA22_RS10340	COG1122	ATPase activity
HHA22_RS10355	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HHA22_RS10360	COG2900	Belongs to the SlyX family
HHA22_RS10375	COG0456	acetyltransferase
HHA22_RS10380	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HHA22_RS10415	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HHA22_RS10435	COG1335	isochorismatase
HHA22_RS10450	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HHA22_RS10500	COG0066	3-isopropylmalate dehydratase activity
HHA22_RS10505	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HHA22_RS10510	COG3181	Tripartite tricarboxylate transporter family receptor
HHA22_RS10515	COG4948	Mandelate Racemase Muconate Lactonizing
HHA22_RS10520	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HHA22_RS10525	COG3842	ATPase activity
HHA22_RS10530	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HHA22_RS10540	COG3833	ABC-type maltose transport systems, permease component
HHA22_RS10545	COG1175	transmembrane transport
HHA22_RS10550	COG2182	Extracellular solute-binding protein
HHA22_RS10560	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HHA22_RS10565	COG0765	amino acid transport
HHA22_RS10570	COG0765	amino acid transport
HHA22_RS10585	COG3665	Urea carboxylase-associated protein
HHA22_RS10605	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HHA22_RS10630	COG0583	DNA-binding transcription factor activity
HHA22_RS10645	COG1126	abc transporter atp-binding protein
HHA22_RS10665	COG1012	belongs to the aldehyde dehydrogenase family
HHA22_RS10675	COG1937	Protein conserved in bacteria
HHA22_RS10695	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HHA22_RS10705	COG3842	ATPase activity
HHA22_RS10710	COG1177	transmembrane transport
HHA22_RS10720	COG1028	Short-chain dehydrogenase reductase Sdr
HHA22_RS10740	COG0583	DNA-binding transcription factor activity
HHA22_RS10745	COG2186	Transcriptional regulator
HHA22_RS10750	COG0129	dihydroxy-acid dehydratase activity
HHA22_RS10755	COG0477	Major facilitator Superfamily
HHA22_RS10770	COG1028	Short-chain dehydrogenase reductase Sdr
HHA22_RS10795	COG2863	cytochrome
HHA22_RS10800	COG3568	Endonuclease Exonuclease Phosphatase
HHA22_RS10805	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HHA22_RS10810	COG0392	lysyltransferase activity
HHA22_RS10815	COG0166	Belongs to the GPI family
HHA22_RS10820	COG0166	Belongs to the GPI family
HHA22_RS10835	COG1058	Belongs to the CinA family
HHA22_RS10835	COG1546	Belongs to the CinA family
HHA22_RS10845	COG0668	transmembrane transport
HHA22_RS10850	COG0297	glycogen (starch) synthase activity
HHA22_RS10860	COG0366	Alpha amylase catalytic
HHA22_RS10865	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HHA22_RS10875	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HHA22_RS10880	COG1640	4-alpha-glucanotransferase
HHA22_RS10910	COG3685	Protein conserved in bacteria
HHA22_RS10915	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HHA22_RS10920	COG1028	Short-chain dehydrogenase reductase Sdr
HHA22_RS10930	COG1216	Glycosyl transferase, family 2
HHA22_RS10965	COG2192	nodulation
HHA22_RS10975	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HHA22_RS10980	COG1028	Short-chain dehydrogenase reductase Sdr
HHA22_RS10985	COG0438	transferase activity, transferring glycosyl groups
HHA22_RS11000	COG5265	(ABC) transporter
HHA22_RS11020	COG0028	Belongs to the TPP enzyme family
HHA22_RS11025	COG2204	response regulator
HHA22_RS11030	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HHA22_RS11035	COG0583	DNA-binding transcription factor activity
HHA22_RS11040	COG0477	Major facilitator Superfamily
HHA22_RS11045	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HHA22_RS11065	COG1137	ATPase activity
HHA22_RS11090	COG1172	Belongs to the binding-protein-dependent transport system permease family
HHA22_RS11095	COG1129	ABC transporter
HHA22_RS11135	COG0402	S-adenosylhomocysteine deaminase activity
HHA22_RS11140	COG0747	negative chemotaxis
HHA22_RS11145	COG0601	transmembrane transport
HHA22_RS11150	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HHA22_RS11155	COG4172	Belongs to the ABC transporter superfamily
HHA22_RS11160	COG1063	alcohol dehydrogenase
HHA22_RS11185	COG2175	clavaminate synthase activity
HHA22_RS11190	COG1454	alcohol dehydrogenase
HHA22_RS11200	COG1024	Enoyl-CoA hydratase
HHA22_RS11205	COG3181	Tripartite tricarboxylate transporter family receptor
HHA22_RS11210	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HHA22_RS11220	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HHA22_RS11230	COG1250	3-hydroxyacyl-CoA dehydrogenase
HHA22_RS11230	COG1024	Enoyl-CoA hydratase
HHA22_RS11235	COG0183	Belongs to the thiolase family
HHA22_RS11240	COG1960	acyl-CoA dehydrogenase activity
HHA22_RS11245	COG0318	PFAM AMP-dependent synthetase and ligase
HHA22_RS11250	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HHA22_RS11265	COG0154	amidase activity
HHA22_RS11270	COG2271	Major facilitator Superfamily
HHA22_RS11280	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HHA22_RS11310	COG0318	PFAM AMP-dependent synthetase and ligase
HHA22_RS11320	COG2267	carboxylic ester hydrolase activity
HHA22_RS11330	COG1024	Enoyl-CoA hydratase
HHA22_RS11340	COG0431	NADPH-dependent FMN reductase
HHA22_RS11355	COG0683	leucine binding
HHA22_RS11380	COG2819	hydrolase of the alpha beta superfamily
HHA22_RS11395	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HHA22_RS11405	COG1619	proteins homologs of microcin C7 resistance protein MccF
HHA22_RS11435	COG1126	abc transporter atp-binding protein
HHA22_RS11440	COG0765	amino acid transport
HHA22_RS11445	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HHA22_RS11475	COG0410	ABC transporter
HHA22_RS11495	COG2200	EAL domain
HHA22_RS11505	COG1595	DNA-templated transcription, initiation
HHA22_RS11525	COG1253	flavin adenine dinucleotide binding
HHA22_RS11535	COG2203	Gaf domain
HHA22_RS11535	COG5001	Diguanylate cyclase
HHA22_RS11535	COG4251	negative regulation of phosphorylation
HHA22_RS11535	COG3706	GGDEF domain
HHA22_RS11540	COG2197	response regulator
HHA22_RS11545	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HHA22_RS11545	COG2205	protein histidine kinase activity
HHA22_RS11550	COG2814	Major facilitator Superfamily
HHA22_RS11555	COG0076	glutamate decarboxylase activity
HHA22_RS11560	COG2985	domain, Protein
HHA22_RS11565	COG3189	MarR family transcriptional regulator
HHA22_RS11570	COG2186	Transcriptional regulator
HHA22_RS11575	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HHA22_RS11585	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HHA22_RS11585	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HHA22_RS11595	COG0028	Belongs to the TPP enzyme family
HHA22_RS11605	COG1012	belongs to the aldehyde dehydrogenase family
HHA22_RS11615	COG0688	phosphatidylethanolamine metabolic process
HHA22_RS11625	COG1464	Belongs to the NlpA lipoprotein family
HHA22_RS11645	COG2363	Small membrane protein
HHA22_RS11650	COG2133	pyrroloquinoline quinone binding
HHA22_RS11655	COG0625	glutathione transferase activity
HHA22_RS11665	COG1794	racemase activity, acting on amino acids and derivatives
HHA22_RS11685	COG0559	Belongs to the binding-protein-dependent transport system permease family
HHA22_RS11695	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HHA22_RS11710	COG1175	transmembrane transport
HHA22_RS11715	COG0395	ABC-type sugar transport system, permease component
HHA22_RS11720	COG3842	ATPase activity
HHA22_RS11735	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HHA22_RS11750	COG0438	transferase activity, transferring glycosyl groups
HHA22_RS11770	COG1216	Glycosyl transferase, family 2
HHA22_RS11785	COG0783	Belongs to the Dps family
HHA22_RS11795	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
HHA22_RS11810	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HHA22_RS11855	COG0583	DNA-binding transcription factor activity
HHA22_RS11880	COG1840	ABC-type Fe3 transport system, periplasmic component
HHA22_RS11890	COG3842	ATPase activity
HHA22_RS11895	COG1741	Belongs to the pirin family
HHA22_RS11900	COG1741	Belongs to the pirin family
HHA22_RS11905	COG0583	DNA-binding transcription factor activity
HHA22_RS11935	COG3852	Histidine kinase
HHA22_RS11940	COG0174	glutamine synthetase
HHA22_RS11945	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HHA22_RS11950	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HHA22_RS11955	COG3300	MHYT domain
HHA22_RS11955	COG5001	Diguanylate cyclase
HHA22_RS11960	COG0840	transmembrane signaling receptor activity
HHA22_RS11970	COG1960	acyl-CoA dehydrogenase activity
HHA22_RS11975	COG2079	MmgE PrpD family protein
HHA22_RS11985	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HHA22_RS11990	COG1561	YicC-like family, N-terminal region
HHA22_RS12005	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HHA22_RS12010	COG0791	NLP P60 protein
HHA22_RS12015	COG1028	Short-chain dehydrogenase reductase Sdr
HHA22_RS12020	COG0194	GDP metabolic process
HHA22_RS12025	COG1758	RNA polymerase activity
HHA22_RS12030	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HHA22_RS12035	COG1126	abc transporter atp-binding protein
HHA22_RS12040	COG0765	amino acid transport
HHA22_RS12045	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HHA22_RS12070	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HHA22_RS12085	COG2831	hemolysin activation secretion protein
HHA22_RS12095	COG3188	usher protein
HHA22_RS12100	COG3121	Chaperone
HHA22_RS12110	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
HHA22_RS12110	COG3210	domain, Protein
HHA22_RS12110	COG3064	Membrane
HHA22_RS12120	COG4181	ATPase activity
HHA22_RS12130	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HHA22_RS12135	COG0584	glycerophosphoryl diester phosphodiesterase
HHA22_RS12140	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HHA22_RS12150	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HHA22_RS12150	COG0678	peroxiredoxin activity
HHA22_RS12165	COG0789	Transcriptional regulator
HHA22_RS12170	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HHA22_RS12195	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HHA22_RS12205	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HHA22_RS12225	COG3618	amidohydrolase
HHA22_RS12230	COG0583	DNA-binding transcription factor activity
HHA22_RS12235	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HHA22_RS12240	COG2252	PERMEase
HHA22_RS12245	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HHA22_RS12250	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HHA22_RS12280	COG0583	DNA-binding transcription factor activity
HHA22_RS12285	COG0655	NAD(P)H dehydrogenase (quinone) activity
HHA22_RS12290	COG0488	(ABC) transporter
HHA22_RS12295	COG1619	proteins homologs of microcin C7 resistance protein MccF
HHA22_RS12315	COG1320	monovalent cation:proton antiporter activity
HHA22_RS12320	COG2212	antiporter activity
HHA22_RS12330	COG0651	ATP synthesis coupled electron transport
HHA22_RS12335	COG1006	Multisubunit Na H antiporter MnhC subunit
HHA22_RS12340	COG2111	Na H antiporter
HHA22_RS12340	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HHA22_RS12355	COG0420	3'-5' exonuclease activity
HHA22_RS12360	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HHA22_RS12365	COG1522	sequence-specific DNA binding
HHA22_RS12380	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HHA22_RS12405	COG2130	NADP-dependent
HHA22_RS12420	COG1131	(ABC) transporter
HHA22_RS12425	COG0842	Transport permease protein
HHA22_RS12435	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HHA22_RS12470	COG0235	Class ii aldolase
HHA22_RS12475	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HHA22_RS12480	COG1012	belongs to the aldehyde dehydrogenase family
HHA22_RS12490	COG1414	Transcriptional regulator
HHA22_RS12495	COG0602	queuosine metabolic process
HHA22_RS12500	COG0720	synthase
HHA22_RS12510	COG1289	transmembrane transporter activity
HHA22_RS12520	COG1566	PFAM secretion protein HlyD family protein
HHA22_RS12530	COG0400	carboxylic ester hydrolase activity
HHA22_RS12550	COG0587	DNA-directed DNA polymerase activity
HHA22_RS12560	COG0390	transport system, permease component
HHA22_RS12565	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HHA22_RS12570	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
HHA22_RS12610	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HHA22_RS12615	COG1280	lysine exporter protein (LysE YggA)
HHA22_RS12620	COG1280	lysine exporter protein (LysE YggA)
HHA22_RS12625	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HHA22_RS12645	COG2764	glyoxalase bleomycin resistance protein dioxygenase
HHA22_RS12670	COG3181	Tripartite tricarboxylate transporter family receptor
HHA22_RS12695	COG0583	DNA-binding transcription factor activity
HHA22_RS12715	COG1522	sequence-specific DNA binding
HHA22_RS12725	COG2814	Major facilitator Superfamily
HHA22_RS12740	COG1396	sequence-specific DNA binding
HHA22_RS12760	COG0183	Belongs to the thiolase family
HHA22_RS12770	COG0583	DNA-binding transcription factor activity
HHA22_RS12775	COG2814	Major facilitator Superfamily
HHA22_RS12780	COG0656	L-ascorbic acid biosynthetic process
HHA22_RS12785	COG2807	transmembrane transport
HHA22_RS12795	COG1595	DNA-templated transcription, initiation
HHA22_RS12800	COG3712	iron ion homeostasis
HHA22_RS12805	COG4774	siderophore transport
HHA22_RS12810	COG2814	Major facilitator Superfamily
HHA22_RS12815	COG0583	DNA-binding transcription factor activity
HHA22_RS12820	COG1028	Short-chain dehydrogenase reductase Sdr
HHA22_RS12835	COG1349	DNA-binding transcription factor activity
HHA22_RS12845	COG1012	belongs to the aldehyde dehydrogenase family
HHA22_RS12855	COG0411	ABC transporter
HHA22_RS12895	COG0384	phenazine biosynthesis protein PhzF
HHA22_RS12900	COG3181	Tripartite tricarboxylate transporter family receptor
HHA22_RS12990	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HHA22_RS12990	COG0519	Catalyzes the synthesis of GMP from XMP
HHA22_RS13005	COG1695	Transcriptional regulator
HHA22_RS13020	COG2072	flavoprotein involved in K transport
HHA22_RS13025	COG0601	transmembrane transport
HHA22_RS13035	COG0444	Belongs to the ABC transporter superfamily
HHA22_RS13040	COG4608	Belongs to the ABC transporter superfamily
HHA22_RS13045	COG0747	negative chemotaxis
HHA22_RS13085	COG0047	phosphoribosylformylglycinamidine synthase activity
HHA22_RS13085	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HHA22_RS13090	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HHA22_RS13095	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HHA22_RS13095	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HHA22_RS13100	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HHA22_RS13110	COG0613	PHP domain protein
HHA22_RS13135	COG2501	S4 domain
HHA22_RS13140	COG0084	hydrolase, TatD family'
HHA22_RS13145	COG1136	(ABC) transporter
HHA22_RS13160	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HHA22_RS13170	COG1028	Short-chain dehydrogenase reductase Sdr
HHA22_RS13175	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HHA22_RS13185	COG1309	transcriptional regulator
HHA22_RS13190	COG1022	Amp-dependent synthetase and ligase
HHA22_RS13220	COG1024	Enoyl-CoA hydratase
HHA22_RS13225	COG1803	Methylglyoxal synthase
HHA22_RS13235	COG2975	iron-sulfur cluster assembly
HHA22_RS13240	COG0633	Ferredoxin
HHA22_RS13245	COG0443	Heat shock 70 kDa protein
HHA22_RS13250	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HHA22_RS13255	COG0316	Belongs to the HesB IscA family
HHA22_RS13260	COG0822	iron-sulfur transferase activity
HHA22_RS13265	COG1104	cysteine desulfurase activity
HHA22_RS13275	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HHA22_RS13280	COG0556	nucleotide-excision repair
HHA22_RS13290	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HHA22_RS13295	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HHA22_RS13300	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HHA22_RS13305	COG0740	serine-type endopeptidase activity
HHA22_RS13310	COG0544	peptidyl-prolyl cis-trans isomerase activity
HHA22_RS13320	COG1278	Cold shock
HHA22_RS13330	COG1278	Cold shock
HHA22_RS13360	COG3468	outer membrane autotransporter barrel domain protein
HHA22_RS13385	COG2171	N-acyltransferase activity
HHA22_RS13390	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HHA22_RS13395	COG2890	protein-(glutamine-N5) methyltransferase activity
HHA22_RS13400	COG0488	(ABC) transporter
HHA22_RS13405	COG0210	DNA helicase
HHA22_RS13420	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HHA22_RS13420	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HHA22_RS13425	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HHA22_RS13430	COG0196	riboflavin kinase activity
HHA22_RS13435	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HHA22_RS13440	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HHA22_RS13445	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HHA22_RS13455	COG1522	sequence-specific DNA binding
HHA22_RS13470	COG0586	Pfam SNARE associated Golgi protein
HHA22_RS13480	COG0756	dUTP diphosphatase activity
HHA22_RS13485	COG1902	pentaerythritol trinitrate reductase activity
HHA22_RS13490	COG1126	abc transporter atp-binding protein
HHA22_RS13495	COG0765	amino acid transport
HHA22_RS13500	COG0765	amino acid transport
HHA22_RS13505	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HHA22_RS13515	COG2423	ornithine cyclodeaminase activity
HHA22_RS13520	COG1764	response to oxidative stress
HHA22_RS13525	COG1914	H( )-stimulated, divalent metal cation uptake system
HHA22_RS13530	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HHA22_RS13535	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HHA22_RS13550	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HHA22_RS13555	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HHA22_RS13560	COG2197	response regulator
HHA22_RS13565	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HHA22_RS13585	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HHA22_RS13590	COG0840	transmembrane signaling receptor activity
HHA22_RS13760	COG5410	chromosome segregation
HHA22_RS13845	COG1396	sequence-specific DNA binding
HHA22_RS13925	COG0582	viral genome integration into host DNA
HHA22_RS13935	COG0135	phosphoribosylanthranilate isomerase activity
HHA22_RS13940	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HHA22_RS13945	COG0101	tRNA pseudouridine synthase activity
HHA22_RS13955	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HHA22_RS13960	COG0473	3-isopropylmalate dehydrogenase activity
HHA22_RS13965	COG0066	3-isopropylmalate dehydratase activity
HHA22_RS13975	COG2197	response regulator
HHA22_RS13990	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HHA22_RS14000	COG2205	protein histidine kinase activity
HHA22_RS14010	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HHA22_RS14020	COG1295	ribonuclease BN
HHA22_RS14030	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HHA22_RS14060	COG1450	Type ii and iii secretion system protein
HHA22_RS14095	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HHA22_RS14135	COG1028	Short-chain dehydrogenase reductase Sdr
HHA22_RS14150	COG1028	Short-chain dehydrogenase reductase Sdr
HHA22_RS14180	COG0181	hydroxymethylbilane synthase activity
HHA22_RS14185	COG0861	Integral membrane protein TerC family
HHA22_RS14190	COG0861	Integral membrane protein TerC family
HHA22_RS14195	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HHA22_RS14200	COG0045	succinate-CoA ligase (ADP-forming) activity
HHA22_RS14210	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HHA22_RS14220	COG2137	regulation of response to DNA damage stimulus
HHA22_RS14225	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HHA22_RS14250	COG2974	May be involved in recombination
HHA22_RS14255	COG0540	Belongs to the ATCase OTCase family
HHA22_RS14285	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HHA22_RS14315	COG0500	methyltransferase
HHA22_RS14320	COG1028	Short-chain dehydrogenase reductase Sdr
HHA22_RS14335	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HHA22_RS14340	COG0747	negative chemotaxis
HHA22_RS14365	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HHA22_RS14390	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HHA22_RS14420	COG0811	peptide transport
HHA22_RS14455	COG2188	Transcriptional regulator
HHA22_RS14460	COG3181	Tripartite tricarboxylate transporter family receptor
HHA22_RS14475	COG0583	DNA-binding transcription factor activity
HHA22_RS14485	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HHA22_RS14495	COG4172	Belongs to the ABC transporter superfamily
HHA22_RS14505	COG0601	transmembrane transport
HHA22_RS14510	COG4166	transmembrane transport
HHA22_RS14515	COG2267	carboxylic ester hydrolase activity
HHA22_RS14520	COG4638	Rieske (2fe-2S)
HHA22_RS14530	COG0583	DNA-binding transcription factor activity
HHA22_RS14535	COG2146	nitrite reductase [NAD(P)H] activity
HHA22_RS14540	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HHA22_RS14545	COG1595	DNA-templated transcription, initiation
HHA22_RS14550	COG3712	iron ion homeostasis
HHA22_RS14555	COG4774	siderophore transport
HHA22_RS14580	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HHA22_RS14590	COG3246	L-lysine catabolic process to acetate
HHA22_RS14595	COG3181	Tripartite tricarboxylate transporter family receptor
HHA22_RS14610	COG1028	Short-chain dehydrogenase reductase Sdr
HHA22_RS14615	COG0583	DNA-binding transcription factor activity
HHA22_RS14645	COG0457	Tetratricopeptide repeat
HHA22_RS14650	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HHA22_RS14655	COG1215	transferase activity, transferring glycosyl groups
HHA22_RS14660	COG1215	transferase activity, transferring glycosyl groups
HHA22_RS14665	COG1215	transferase activity, transferring glycosyl groups
HHA22_RS14670	COG0003	Pfam Anion-transporting ATPase
HHA22_RS14690	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HHA22_RS14730	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HHA22_RS14745	COG1215	transferase activity, transferring glycosyl groups
HHA22_RS14755	COG3307	-O-antigen
HHA22_RS14780	COG3181	Tripartite tricarboxylate transporter family receptor
HHA22_RS14790	COG2030	dehydratase
HHA22_RS14805	COG1024	Enoyl-CoA hydratase
HHA22_RS14855	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HHA22_RS14860	COG1028	Short-chain dehydrogenase reductase Sdr
HHA22_RS14875	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HHA22_RS14885	COG1960	acyl-CoA dehydrogenase activity
HHA22_RS14890	COG1960	acyl-CoA dehydrogenase activity
HHA22_RS14895	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HHA22_RS14905	COG0583	DNA-binding transcription factor activity
HHA22_RS14910	COG0372	Belongs to the citrate synthase family
HHA22_RS14955	COG0701	Predicted permease
HHA22_RS14965	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HHA22_RS15000	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HHA22_RS15010	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HHA22_RS15015	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HHA22_RS15025	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HHA22_RS15030	COG3620	sequence-specific DNA binding
HHA22_RS15035	COG2233	PERMEase
HHA22_RS15065	COG0406	alpha-ribazole phosphatase activity
HHA22_RS15070	COG4221	oxidoreductase activity
HHA22_RS15080	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HHA22_RS15085	COG0505	Belongs to the CarA family
HHA22_RS15090	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HHA22_RS15095	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HHA22_RS15105	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HHA22_RS15110	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HHA22_RS15115	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HHA22_RS15120	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HHA22_RS15125	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HHA22_RS15135	COG1074	ATP-dependent DNA helicase activity
HHA22_RS15155	COG1686	Belongs to the peptidase S11 family
HHA22_RS15165	COG0693	protein deglycase activity
HHA22_RS15175	COG4974	Belongs to the 'phage' integrase family
HHA22_RS15180	COG0583	DNA-binding transcription factor activity
HHA22_RS15185	COG0028	Belongs to the TPP enzyme family
HHA22_RS15190	COG1960	acyl-CoA dehydrogenase activity
HHA22_RS15200	COG0028	Belongs to the TPP enzyme family
HHA22_RS15205	COG1126	abc transporter atp-binding protein
HHA22_RS15210	COG0765	amino acid transport
HHA22_RS15215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HHA22_RS15230	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HHA22_RS15235	COG0009	L-threonylcarbamoyladenylate synthase
HHA22_RS15240	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HHA22_RS15245	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HHA22_RS15260	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HHA22_RS15270	COG1301	dicarboxylic acid transport
HHA22_RS15275	COG0456	acetyltransferase
HHA22_RS15305	COG3454	Phosphonate metabolism
HHA22_RS15310	COG4778	phosphonate C-P lyase system protein PhnL
HHA22_RS15315	COG4107	phosphonate C-P lyase system protein PhnK
HHA22_RS15320	COG3627	carbon phosphorus lyase activity
HHA22_RS15325	COG3626	phosphonate metabolism
HHA22_RS15335	COG3624	Phosphonate C-P lyase system protein PhnG
HHA22_RS15340	COG2188	Transcriptional regulator
HHA22_RS15345	COG3454	Phosphonate metabolism
HHA22_RS15355	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
HHA22_RS15360	COG3639	organic phosphonate transmembrane transporter activity
HHA22_RS15365	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
HHA22_RS15370	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HHA22_RS15375	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HHA22_RS15385	COG0739	heme binding
HHA22_RS15395	COG0521	Mo-molybdopterin cofactor biosynthetic process
HHA22_RS15400	COG0306	phosphate transporter
HHA22_RS15445	COG0625	glutathione transferase activity
HHA22_RS15465	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HHA22_RS15470	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HHA22_RS15480	COG0126	phosphoglycerate kinase activity
HHA22_RS15485	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HHA22_RS15490	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HHA22_RS15495	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HHA22_RS15510	COG0280	phosphate acetyltransferase
HHA22_RS15510	COG0281	malic enzyme
HHA22_RS15520	COG0436	Aminotransferase
HHA22_RS15525	COG0741	lytic transglycosylase activity
HHA22_RS15530	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HHA22_RS15545	COG4575	ribosome binding
HHA22_RS15555	COG1648	precorrin-2 dehydrogenase activity
HHA22_RS15555	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HHA22_RS15560	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HHA22_RS15565	COG2027	D-alanyl-D-alanine carboxypeptidase
HHA22_RS15570	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HHA22_RS15575	COG0343	queuine tRNA-ribosyltransferase activity
HHA22_RS15580	COG1862	Preprotein translocase
HHA22_RS15585	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HHA22_RS15590	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HHA22_RS15620	COG0667	Aldo Keto reductase
HHA22_RS15625	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HHA22_RS15630	COG4535	Mg2 and Co2 transporter CorC
HHA22_RS15635	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HHA22_RS15640	COG1702	phosphate starvation-inducible protein PhoH
HHA22_RS15645	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HHA22_RS15695	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HHA22_RS15700	COG0697	spore germination
HHA22_RS15710	COG0494	nUDIX hydrolase
HHA22_RS15720	COG0583	DNA-binding transcription factor activity
HHA22_RS15725	COG3530	Putative quorum-sensing-regulated virulence factor
HHA22_RS15735	COG2814	Major facilitator Superfamily
HHA22_RS15755	COG4608	Belongs to the ABC transporter superfamily
HHA22_RS15760	COG0444	Belongs to the ABC transporter superfamily
HHA22_RS15765	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HHA22_RS15775	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HHA22_RS15780	COG0583	DNA-binding transcription factor activity
HHA22_RS15820	COG2814	Major facilitator Superfamily
HHA22_RS15830	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
HHA22_RS15840	COG0628	permease
HHA22_RS15845	COG0842	Transport permease protein
HHA22_RS15850	COG1131	(ABC) transporter
HHA22_RS15855	COG1764	response to oxidative stress
HHA22_RS15860	COG1846	Transcriptional regulator
HHA22_RS15875	COG0348	domain, Protein
HHA22_RS15895	COG3278	Belongs to the heme-copper respiratory oxidase family
HHA22_RS15905	COG2217	Heavy metal translocating P-type atpase
HHA22_RS15910	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HHA22_RS15915	COG0156	8-amino-7-oxononanoate synthase activity
HHA22_RS15925	COG4106	trans-aconitate 2-methyltransferase activity
HHA22_RS15925	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HHA22_RS15930	COG2224	Isocitrate lyase
HHA22_RS15935	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HHA22_RS15935	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HHA22_RS15945	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HHA22_RS15955	COG1472	Belongs to the glycosyl hydrolase 3 family
HHA22_RS15960	COG0736	holo-[acyl-carrier-protein] synthase activity
HHA22_RS15965	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HHA22_RS15975	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HHA22_RS15980	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HHA22_RS15985	COG0745	RESPONSE REGULATOR receiver
HHA22_RS16005	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HHA22_RS16010	COG4149	molybdate abc transporter
HHA22_RS16015	COG0725	ABC transporter, periplasmic molybdate-binding protein
HHA22_RS16025	COG4120	Belongs to the binding-protein-dependent transport system permease family
HHA22_RS16035	COG0667	Aldo Keto reductase
HHA22_RS16040	COG2032	superoxide dismutase activity
HHA22_RS16050	COG0318	PFAM AMP-dependent synthetase and ligase
HHA22_RS16055	COG1024	Enoyl-CoA hydratase
HHA22_RS16065	COG1802	Transcriptional regulator
HHA22_RS16085	COG1217	gtp-binding protein TYPA
HHA22_RS16090	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HHA22_RS16095	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HHA22_RS16100	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HHA22_RS16105	COG0195	Participates in both transcription termination and antitermination
HHA22_RS16105	COG2251	uridine kinase activity
HHA22_RS16110	COG0779	Required for maturation of 30S ribosomal subunits
HHA22_RS16115	COG1187	pseudouridine synthase activity
HHA22_RS16120	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HHA22_RS16130	COG0583	DNA-binding transcription factor activity
HHA22_RS16135	COG0523	cobalamin synthesis protein
HHA22_RS16165	COG0625	glutathione transferase activity
HHA22_RS16170	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HHA22_RS16180	COG2003	Belongs to the UPF0758 family
HHA22_RS16185	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
HHA22_RS16190	COG3483	tryptophan 2,3-dioxygenase activity
HHA22_RS16195	COG0254	rRNA binding
HHA22_RS16230	COG1028	Short-chain dehydrogenase reductase Sdr
HHA22_RS16235	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HHA22_RS16245	COG1562	ergosterol biosynthetic process
HHA22_RS16250	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
HHA22_RS16250	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
HHA22_RS16255	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HHA22_RS16280	COG1477	protein flavinylation
HHA22_RS16285	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HHA22_RS16295	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HHA22_RS16305	COG0542	response to heat
HHA22_RS16315	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HHA22_RS16330	COG0678	peroxiredoxin activity
HHA22_RS16340	COG0412	Dienelactone hydrolase
HHA22_RS16350	COG0315	cyclic pyranopterin monophosphate synthase activity
HHA22_RS16360	COG0314	molybdopterin synthase activity
HHA22_RS16365	COG0521	Mo-molybdopterin cofactor biosynthetic process
HHA22_RS16370	COG0303	'Molybdopterin
HHA22_RS16375	COG0746	molybdenum cofactor guanylyltransferase activity
HHA22_RS16380	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HHA22_RS16400	COG3383	formate dehydrogenase (NAD+) activity
HHA22_RS16415	COG2264	protein methyltransferase activity
HHA22_RS16435	COG5006	permease, DMT superfamily
HHA22_RS16440	COG1028	Short-chain dehydrogenase reductase Sdr
HHA22_RS16490	COG1129	ABC transporter
HHA22_RS16500	COG1666	GTP binding
HHA22_RS16530	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HHA22_RS16535	COG1845	cytochrome c oxidase, subunit III
HHA22_RS16540	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HHA22_RS16550	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
HHA22_RS16575	COG0783	Belongs to the Dps family
HHA22_RS16580	COG1028	Short-chain dehydrogenase reductase Sdr
HHA22_RS16590	COG1346	cytolysis
HHA22_RS16595	COG1380	Effector of murein hydrolase LrgA
HHA22_RS16600	COG0583	DNA-binding transcription factor activity
HHA22_RS16610	COG4172	Belongs to the ABC transporter superfamily
HHA22_RS16615	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HHA22_RS16620	COG0601	transmembrane transport
HHA22_RS16625	COG0747	negative chemotaxis
HHA22_RS16635	COG0598	Magnesium transport protein CorA
HHA22_RS16640	COG0210	DNA helicase
HHA22_RS16655	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HHA22_RS16660	COG1012	belongs to the aldehyde dehydrogenase family
HHA22_RS16670	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HHA22_RS16680	COG1045	serine acetyltransferase
HHA22_RS16685	COG1309	transcriptional regulator
HHA22_RS16690	COG1960	acyl-CoA dehydrogenase activity
HHA22_RS16700	COG1024	Enoyl-CoA hydratase
HHA22_RS16700	COG1250	3-hydroxyacyl-CoA dehydrogenase
HHA22_RS16705	COG2067	long-chain fatty acid transport protein
HHA22_RS16710	COG1024	Enoyl-CoA hydratase
HHA22_RS16710	COG1250	3-hydroxyacyl-CoA dehydrogenase
HHA22_RS16715	COG0183	Belongs to the thiolase family
HHA22_RS16730	COG0318	PFAM AMP-dependent synthetase and ligase
HHA22_RS16740	COG1902	pentaerythritol trinitrate reductase activity
HHA22_RS16765	COG0251	oxidation-reduction process
HHA22_RS16775	COG1832	CoA-binding protein
HHA22_RS16780	COG1414	Transcriptional regulator
HHA22_RS16800	COG4993	Dehydrogenase
HHA22_RS16810	COG4772	TonB-dependent receptor
HHA22_RS16815	COG2814	Major facilitator Superfamily
HHA22_RS16830	COG1132	(ABC) transporter
HHA22_RS16845	COG0037	tRNA processing
HHA22_RS16850	COG0825	malonyl-CoA metabolic process
HHA22_RS16860	COG0215	cysteine-tRNA ligase activity
HHA22_RS16870	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HHA22_RS16875	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HHA22_RS16880	COG1968	undecaprenyl-diphosphatase activity
HHA22_RS16885	COG1253	flavin adenine dinucleotide binding
HHA22_RS16890	COG0483	inositol monophosphate 1-phosphatase activity
HHA22_RS16895	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HHA22_RS16910	COG0668	transmembrane transport
HHA22_RS16935	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HHA22_RS16945	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HHA22_RS16980	COG3360	Dodecin
HHA22_RS17000	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HHA22_RS17005	COG2850	peptidyl-arginine hydroxylation
HHA22_RS17015	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HHA22_RS17020	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HHA22_RS17025	COG1994	Peptidase M50
HHA22_RS17030	COG0009	L-threonylcarbamoyladenylate synthase
HHA22_RS17035	COG2321	neutral zinc metallopeptidase
HHA22_RS17060	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HHA22_RS17065	COG0583	DNA-binding transcription factor activity
HHA22_RS17095	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HHA22_RS17105	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HHA22_RS17115	COG2072	flavoprotein involved in K transport
HHA22_RS17120	COG3842	ATPase activity
HHA22_RS17125	COG0604	alcohol dehydrogenase
HHA22_RS17125	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HHA22_RS17125	COG3321	synthase
HHA22_RS17125	COG4221	oxidoreductase activity
HHA22_RS17135	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HHA22_RS17140	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HHA22_RS17145	COG1177	transmembrane transport
HHA22_RS17150	COG1176	ABC-type spermidine putrescine transport system, permease component I
HHA22_RS17160	COG1126	abc transporter atp-binding protein
HHA22_RS17165	COG0765	amino acid transport
HHA22_RS17175	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HHA22_RS17185	COG0251	oxidation-reduction process
HHA22_RS17200	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HHA22_RS17215	COG2020	methyltransferase activity
HHA22_RS17235	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HHA22_RS17240	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HHA22_RS17240	COG3608	succinylglutamate desuccinylase aspartoacylase
HHA22_RS17250	COG1012	belongs to the aldehyde dehydrogenase family
HHA22_RS17280	COG4172	Belongs to the ABC transporter superfamily
HHA22_RS17320	COG2202	Pas domain
HHA22_RS17320	COG2200	EAL domain
HHA22_RS17320	COG2199	diguanylate cyclase activity
HHA22_RS17325	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
HHA22_RS17330	COG1414	Transcriptional regulator
HHA22_RS17350	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HHA22_RS17380	COG1960	acyl-CoA dehydrogenase activity
HHA22_RS17385	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HHA22_RS17390	COG2186	Transcriptional regulator
HHA22_RS17405	COG1028	Short-chain dehydrogenase reductase Sdr
HHA22_RS17415	COG0179	Fumarylacetoacetate (FAA) hydrolase
HHA22_RS17435	COG4604	ABC transporter, ATP-binding protein
HHA22_RS17440	COG4605	iron ion homeostasis
HHA22_RS17445	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HHA22_RS17450	COG4607	ABC-type enterochelin transport system periplasmic component
HHA22_RS17455	COG0438	transferase activity, transferring glycosyl groups
HHA22_RS17460	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HHA22_RS17465	COG0149	triose-phosphate isomerase activity
HHA22_RS17470	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HHA22_RS17470	COG4221	oxidoreductase activity
HHA22_RS17470	COG3321	synthase
HHA22_RS17470	COG0604	alcohol dehydrogenase
HHA22_RS17495	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HHA22_RS17500	COG0583	DNA-binding transcription factor activity
HHA22_RS17530	COG1185	polyribonucleotide nucleotidyltransferase activity
HHA22_RS17535	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HHA22_RS17545	COG1183	phosphatidylcholine synthase activity
HHA22_RS17550	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HHA22_RS17555	COG0440	acetolactate synthase activity
HHA22_RS17560	COG0028	Belongs to the TPP enzyme family
HHA22_RS17565	COG1289	transmembrane transporter activity
HHA22_RS17570	COG3022	response to hydroperoxide
HHA22_RS17575	COG1028	Short-chain dehydrogenase reductase Sdr
HHA22_RS17600	COG1309	transcriptional regulator
HHA22_RS17615	COG2186	Transcriptional regulator
HHA22_RS17620	COG4638	Rieske (2fe-2S)
HHA22_RS17625	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
HHA22_RS17630	COG3181	Tripartite tricarboxylate transporter family receptor
HHA22_RS17685	COG2095	MarC family integral membrane protein
HHA22_RS17695	COG3447	MASE1 domain protein
HHA22_RS17695	COG5001	Diguanylate cyclase
HHA22_RS17695	COG5002	protein histidine kinase activity
HHA22_RS17720	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HHA22_RS17735	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HHA22_RS17750	COG0601	transmembrane transport
HHA22_RS17770	COG0517	IMP dehydrogenase activity
HHA22_RS17770	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HHA22_RS17775	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HHA22_RS17785	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HHA22_RS17790	COG1674	ftsk spoiiie
HHA22_RS17795	COG0492	ferredoxin-NADP+ reductase activity
HHA22_RS17810	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HHA22_RS17825	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HHA22_RS17830	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HHA22_RS17835	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HHA22_RS17840	COG2205	protein histidine kinase activity
HHA22_RS17845	COG0745	RESPONSE REGULATOR receiver
HHA22_RS17860	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HHA22_RS17885	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HHA22_RS17900	COG0612	Peptidase, M16
HHA22_RS17905	COG0484	heat shock protein binding
HHA22_RS17910	COG0443	Heat shock 70 kDa protein
HHA22_RS17920	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HHA22_RS17930	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HHA22_RS17935	COG1420	regulation of RNA biosynthetic process
HHA22_RS17940	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HHA22_RS17945	COG0497	DNA recombination
HHA22_RS17950	COG0735	belongs to the Fur family
HHA22_RS17955	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HHA22_RS17980	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HHA22_RS18010	COG2828	Protein conserved in bacteria
HHA22_RS18015	COG1280	lysine exporter protein (LysE YggA)
HHA22_RS18035	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HHA22_RS18040	COG1802	Transcriptional regulator
HHA22_RS18045	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HHA22_RS18050	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HHA22_RS18055	COG1335	isochorismatase
HHA22_RS18060	COG0523	cobalamin synthesis protein
HHA22_RS18095	COG0741	lytic transglycosylase activity
HHA22_RS18290	COG3723	Recombinational DNA repair protein, rece pathway
HHA22_RS18360	COG0583	DNA-binding transcription factor activity
HHA22_RS18370	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HHA22_RS18375	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
HHA22_RS18380	COG0167	dihydroorotate dehydrogenase activity
HHA22_RS18395	COG1414	Transcriptional regulator
HHA22_RS18400	COG1546	Belongs to the CinA family
HHA22_RS18400	COG1058	Belongs to the CinA family
HHA22_RS18415	COG0513	Belongs to the DEAD box helicase family
HHA22_RS18440	COG0429	hydrolase of the alpha beta-hydrolase fold
HHA22_RS18445	COG4783	chaperone-mediated protein folding
HHA22_RS18465	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HHA22_RS18480	COG0006	proline dipeptidase activity
HHA22_RS18490	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HHA22_RS18510	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HHA22_RS18515	COG0632	four-way junction helicase activity
HHA22_RS18525	COG0702	epimerase
HHA22_RS18530	COG2255	four-way junction helicase activity
HHA22_RS18535	COG0514	ATP-dependent DNA helicase (RecQ)
HHA22_RS18555	COG1294	oxidase, subunit
HHA22_RS18565	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HHA22_RS18570	COG0850	regulation of cytokinetic process
HHA22_RS18575	COG2894	cell division
HHA22_RS18580	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HHA22_RS18595	COG0488	(ABC) transporter
HHA22_RS18600	COG2066	Belongs to the glutaminase family
HHA22_RS18605	COG0531	amino acid
HHA22_RS18615	COG0531	amino acid
HHA22_RS18625	COG0076	glutamate decarboxylase activity
HHA22_RS18640	COG4608	Belongs to the ABC transporter superfamily
HHA22_RS18645	COG0444	Belongs to the ABC transporter superfamily
HHA22_RS18650	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HHA22_RS18655	COG0601	transmembrane transport
HHA22_RS18665	COG1215	transferase activity, transferring glycosyl groups
HHA22_RS18670	COG0583	DNA-binding transcription factor activity
HHA22_RS18675	COG1802	Transcriptional regulator
HHA22_RS18680	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HHA22_RS18690	COG1024	Enoyl-CoA hydratase
HHA22_RS18715	COG1137	ATPase activity
HHA22_RS18725	COG0154	amidase activity
HHA22_RS18730	COG1368	sulfuric ester hydrolase activity
HHA22_RS18740	COG3685	Protein conserved in bacteria
HHA22_RS18750	COG1686	Belongs to the peptidase S11 family
HHA22_RS18770	COG2832	Protein of unknown function (DUF454)
HHA22_RS18785	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HHA22_RS18815	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HHA22_RS18820	COG1802	Transcriptional regulator
HHA22_RS18825	COG0747	negative chemotaxis
HHA22_RS18830	COG0601	transmembrane transport
HHA22_RS18835	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HHA22_RS18840	COG0444	Belongs to the ABC transporter superfamily
HHA22_RS18845	COG4608	Belongs to the ABC transporter superfamily
HHA22_RS18855	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HHA22_RS18880	COG1012	belongs to the aldehyde dehydrogenase family
HHA22_RS18885	COG1396	sequence-specific DNA binding
HHA22_RS18895	COG1176	ABC-type spermidine putrescine transport system, permease component I
HHA22_RS18900	COG3842	ATPase activity
HHA22_RS18910	COG4191	Histidine kinase
HHA22_RS18910	COG0745	RESPONSE REGULATOR receiver
HHA22_RS18910	COG2205	protein histidine kinase activity
HHA22_RS18915	COG4566	intracellular signal transduction
HHA22_RS18940	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HHA22_RS18945	COG0477	Major facilitator Superfamily
HHA22_RS18950	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HHA22_RS18960	COG0583	DNA-binding transcription factor activity
HHA22_RS18965	COG1414	Transcriptional regulator
HHA22_RS18970	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HHA22_RS18975	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HHA22_RS18980	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HHA22_RS18985	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HHA22_RS18990	COG0583	DNA-binding transcription factor activity
HHA22_RS18995	COG3485	protocatechuate 3,4-dioxygenase
HHA22_RS19000	COG3485	protocatechuate 3,4-dioxygenase
HHA22_RS19010	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HHA22_RS19030	COG1960	acyl-CoA dehydrogenase activity
HHA22_RS19035	COG1028	Short-chain dehydrogenase reductase Sdr
HHA22_RS19045	COG1028	Short-chain dehydrogenase reductase Sdr
HHA22_RS19060	COG0683	leucine binding
HHA22_RS19085	COG0028	Belongs to the TPP enzyme family
HHA22_RS19090	COG1802	Transcriptional regulator
HHA22_RS19095	COG1802	Transcriptional regulator
HHA22_RS19100	COG0513	Belongs to the DEAD box helicase family
HHA22_RS19110	COG1595	DNA-templated transcription, initiation
HHA22_RS19120	COG0583	DNA-binding transcription factor activity
HHA22_RS19135	COG4774	siderophore transport
HHA22_RS19145	COG1595	DNA-templated transcription, initiation
HHA22_RS19160	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HHA22_RS19185	COG0657	acetylesterase activity
HHA22_RS19195	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HHA22_RS19200	COG4569	acetaldehyde dehydrogenase (acetylating) activity
HHA22_RS19210	COG3971	2-oxopent-4-enoate hydratase activity
HHA22_RS19245	COG0459	protein refolding
HHA22_RS19285	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HHA22_RS19290	COG0459	protein refolding
HHA22_RS19300	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HHA22_RS19305	COG1252	NADH dehydrogenase
HHA22_RS19310	COG0284	orotidine-5'-phosphate decarboxylase activity
HHA22_RS19320	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HHA22_RS19330	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HHA22_RS19335	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HHA22_RS19410	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HHA22_RS19415	COG3639	organic phosphonate transmembrane transporter activity
HHA22_RS19420	COG3639	organic phosphonate transmembrane transporter activity
HHA22_RS19435	COG0742	ribosomal rna small subunit methyltransferase
HHA22_RS19440	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HHA22_RS19445	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HHA22_RS19450	COG3135	benzoate transporter
HHA22_RS19490	COG2188	Transcriptional regulator
HHA22_RS19495	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HHA22_RS19500	COG1024	Enoyl-CoA hydratase
HHA22_RS19505	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HHA22_RS19520	COG0318	PFAM AMP-dependent synthetase and ligase
HHA22_RS19525	COG3181	Tripartite tricarboxylate transporter family receptor
HHA22_RS19530	COG2814	Major facilitator Superfamily
HHA22_RS19570	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HHA22_RS19585	COG0582	viral genome integration into host DNA
HHA22_RS19590	COG0012	GTP binding
HHA22_RS19600	COG0193	aminoacyl-tRNA hydrolase activity
HHA22_RS19605	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HHA22_RS19610	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HHA22_RS19620	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HHA22_RS19625	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HHA22_RS19635	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HHA22_RS19645	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HHA22_RS19660	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HHA22_RS19670	COG1368	sulfuric ester hydrolase activity
HHA22_RS19675	COG2186	Transcriptional regulator
HHA22_RS19680	COG5000	phosphorelay sensor kinase activity
HHA22_RS19680	COG5002	protein histidine kinase activity
HHA22_RS19685	COG0745	RESPONSE REGULATOR receiver
HHA22_RS19690	COG0277	FAD linked oxidase domain protein
HHA22_RS19705	COG0166	Belongs to the GPI family
HHA22_RS19710	COG0438	transferase activity, transferring glycosyl groups
HHA22_RS19715	COG0438	transferase activity, transferring glycosyl groups
HHA22_RS19730	COG0438	transferase activity, transferring glycosyl groups
HHA22_RS19745	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HHA22_RS19750	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HHA22_RS19755	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
HHA22_RS19775	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HHA22_RS19780	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HHA22_RS19795	COG0747	negative chemotaxis
HHA22_RS19800	COG0601	transmembrane transport
HHA22_RS19805	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HHA22_RS19810	COG4172	Belongs to the ABC transporter superfamily
HHA22_RS19825	COG5339	Protein conserved in bacteria
HHA22_RS19830	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HHA22_RS19830	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HHA22_RS19835	COG0509	glycine decarboxylation via glycine cleavage system
HHA22_RS19840	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HHA22_RS19850	COG0371	Dehydrogenase
HHA22_RS19875	COG0559	Belongs to the binding-protein-dependent transport system permease family
HHA22_RS19890	COG2081	HI0933 family
HHA22_RS19905	COG1214	PFAM Peptidase M22, glycoprotease
HHA22_RS19905	COG0456	acetyltransferase
HHA22_RS19910	COG0717	Belongs to the dCTP deaminase family
HHA22_RS19925	COG0489	protein tyrosine kinase activity
HHA22_RS19935	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HHA22_RS19935	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HHA22_RS19940	COG1054	Belongs to the UPF0176 family
HHA22_RS19955	COG2194	sulfuric ester hydrolase activity
HHA22_RS19975	COG3539	Fimbrial protein
HHA22_RS19980	COG0010	Belongs to the arginase family
HHA22_RS19995	COG3842	ATPase activity
HHA22_RS20000	COG1176	ABC-type spermidine putrescine transport system, permease component I
HHA22_RS20005	COG1177	transmembrane transport
HHA22_RS20030	COG1028	Short-chain dehydrogenase reductase Sdr
HHA22_RS20045	COG2084	Dehydrogenase
HHA22_RS20050	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HHA22_RS20085	COG2226	methyltransferase
HHA22_RS20085	COG1073	alpha beta
HHA22_RS20105	COG2423	ornithine cyclodeaminase activity
HHA22_RS20120	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HHA22_RS20150	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HHA22_RS20155	COG0765	amino acid transport
HHA22_RS20160	COG0765	amino acid transport
HHA22_RS20170	COG0583	DNA-binding transcription factor activity
HHA22_RS20175	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HHA22_RS20180	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HHA22_RS20180	COG2755	lipolytic protein G-D-S-L family
HHA22_RS20185	COG0625	glutathione transferase activity
HHA22_RS20205	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HHA22_RS20210	COG1960	acyl-CoA dehydrogenase activity
HHA22_RS20215	COG1309	transcriptional regulator
HHA22_RS20250	COG1309	transcriptional regulator
HHA22_RS20255	COG1028	Short-chain dehydrogenase reductase Sdr
HHA22_RS20260	COG0583	DNA-binding transcription factor activity
HHA22_RS20265	COG2072	flavoprotein involved in K transport
HHA22_RS20310	COG0426	domain, Protein
HHA22_RS20310	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HHA22_RS20315	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HHA22_RS20320	COG0583	DNA-binding transcription factor activity
HHA22_RS20325	COG3386	PFAM SMP-30 Gluconolaconase
HHA22_RS20330	COG1024	Enoyl-CoA hydratase
HHA22_RS20340	COG1960	acyl-CoA dehydrogenase activity
HHA22_RS20355	COG1028	Short-chain dehydrogenase reductase Sdr
HHA22_RS20370	COG3181	Tripartite tricarboxylate transporter family receptor
HHA22_RS20375	COG1028	Short-chain dehydrogenase reductase Sdr
HHA22_RS20380	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HHA22_RS20385	COG3181	Tripartite tricarboxylate transporter family receptor
HHA22_RS20390	COG0583	DNA-binding transcription factor activity
HHA22_RS20430	COG4942	peptidase
HHA22_RS20495	COG3077	Addiction module antitoxin, RelB DinJ family
HHA22_RS20535	COG0798	PFAM Bile acid sodium symporter
HHA22_RS20550	COG0640	Transcriptional regulator
HHA22_RS20615	COG2267	carboxylic ester hydrolase activity
HHA22_RS20620	COG0596	Alpha beta hydrolase
HHA22_RS20650	COG0024	Methionine aminopeptidase
HHA22_RS20660	COG2267	carboxylic ester hydrolase activity
HHA22_RS20665	COG0583	DNA-binding transcription factor activity
HHA22_RS20680	COG0583	DNA-binding transcription factor activity
HHA22_RS20685	COG0596	Alpha beta hydrolase
HHA22_RS20695	COG0066	3-isopropylmalate dehydratase activity
HHA22_RS20700	COG2207	Transcriptional regulator
HHA22_RS20760	COG2226	methyltransferase
HHA22_RS20785	COG0582	viral genome integration into host DNA
HHA22_RS20800	COG0277	FAD linked oxidase domain protein
HHA22_RS20805	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HHA22_RS20810	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HHA22_RS20835	COG1012	belongs to the aldehyde dehydrogenase family
HHA22_RS20840	COG0583	DNA-binding transcription factor activity
HHA22_RS20850	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HHA22_RS20865	COG1652	LysM domain
HHA22_RS20870	COG0560	Phosphoserine phosphatase
HHA22_RS20875	COG0583	DNA-binding transcription factor activity
HHA22_RS20880	COG3842	ATPase activity
HHA22_RS20885	COG1178	ABC-type Fe3 transport system permease component
HHA22_RS20895	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HHA22_RS20900	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HHA22_RS20915	COG0625	glutathione transferase activity
HHA22_RS20945	COG4336	lyase activity
HHA22_RS20955	COG1414	Transcriptional regulator
HHA22_RS20960	COG3734	2-keto-3-deoxy-galactonokinase
HHA22_RS20965	COG0800	Aldolase
HHA22_RS20970	COG4948	Mandelate Racemase Muconate Lactonizing
HHA22_RS20975	COG2271	Major facilitator Superfamily
HHA22_RS20980	COG0326	Molecular chaperone. Has ATPase activity
HHA22_RS20985	COG2233	PERMEase
HHA22_RS21065	COG1819	glycosyl
HHA22_RS21075	COG3284	Transcriptional regulator
HHA22_RS21100	COG0509	glycine decarboxylation via glycine cleavage system
HHA22_RS21105	COG0022	dehydrogenase e1 component
HHA22_RS21110	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HHA22_RS21125	COG0235	Class ii aldolase
HHA22_RS21135	COG0436	Aminotransferase
HHA22_RS21225	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HHA22_RS21230	COG4774	siderophore transport
HHA22_RS21235	COG3712	iron ion homeostasis
HHA22_RS21240	COG1595	DNA-templated transcription, initiation
HHA22_RS21245	COG5285	phytanoyl-CoA dioxygenase
HHA22_RS21250	COG0628	permease
HHA22_RS21255	COG0583	DNA-binding transcription factor activity
HHA22_RS21260	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HHA22_RS21280	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
HHA22_RS21290	COG3539	Fimbrial protein
HHA22_RS21295	COG0129	dihydroxy-acid dehydratase activity
HHA22_RS21315	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HHA22_RS21320	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HHA22_RS21325	COG1250	3-hydroxyacyl-CoA dehydrogenase
HHA22_RS21330	COG2031	fatty acid transporter
HHA22_RS21335	COG1028	Short-chain dehydrogenase reductase Sdr
HHA22_RS21340	COG1414	Transcriptional regulator
HHA22_RS21350	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HHA22_RS21355	COG4829	muconolactone delta-isomerase
HHA22_RS21365	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HHA22_RS21385	COG0288	reversible hydration of carbon dioxide
HHA22_RS21390	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HHA22_RS21410	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HHA22_RS21415	COG2890	protein-(glutamine-N5) methyltransferase activity
HHA22_RS21420	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HHA22_RS21425	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HHA22_RS21450	COG0659	secondary active sulfate transmembrane transporter activity
HHA22_RS21480	COG0683	leucine binding
HHA22_RS21485	COG0154	amidase activity
HHA22_RS21610	COG0142	geranyltranstransferase activity
HHA22_RS21615	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HHA22_RS21620	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HHA22_RS21625	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HHA22_RS21630	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HHA22_RS21650	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HHA22_RS21650	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HHA22_RS21655	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HHA22_RS21670	COG0861	Integral membrane protein TerC family
HHA22_RS21675	COG1012	belongs to the aldehyde dehydrogenase family
HHA22_RS21690	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HHA22_RS21695	COG0793	Belongs to the peptidase S41A family
HHA22_RS21700	COG4942	peptidase
HHA22_RS21705	COG0588	phosphoglycerate mutase activity
HHA22_RS21715	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HHA22_RS21720	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HHA22_RS21725	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HHA22_RS21745	COG2226	methyltransferase
HHA22_RS21750	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HHA22_RS21755	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HHA22_RS21760	COG0569	domain protein
HHA22_RS21765	COG2204	response regulator
HHA22_RS21770	COG5000	phosphorelay sensor kinase activity
HHA22_RS21780	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HHA22_RS21780	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HHA22_RS21790	COG0583	DNA-binding transcription factor activity
HHA22_RS21795	COG2814	Major facilitator Superfamily
HHA22_RS21800	COG0583	DNA-binding transcription factor activity
HHA22_RS21810	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HHA22_RS21815	COG3181	Tripartite tricarboxylate transporter family receptor
HHA22_RS21820	COG1250	3-hydroxyacyl-CoA dehydrogenase
HHA22_RS21825	COG2072	flavoprotein involved in K transport
HHA22_RS21830	COG2267	carboxylic ester hydrolase activity
HHA22_RS21860	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HHA22_RS21865	COG0583	DNA-binding transcription factor activity
HHA22_RS21870	COG1012	belongs to the aldehyde dehydrogenase family
HHA22_RS21900	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HHA22_RS21905	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HHA22_RS21920	COG0546	phosphoglycolate phosphatase activity
HHA22_RS21930	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HHA22_RS21935	COG0242	peptide deformylase activity
HHA22_RS21945	COG1522	sequence-specific DNA binding
HHA22_RS21950	COG2879	small protein
HHA22_RS21955	COG1966	Carbon starvation protein
HHA22_RS21970	COG0758	DNA mediated transformation
HHA22_RS21985	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HHA22_RS21990	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HHA22_RS21995	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HHA22_RS22065	COG1172	Belongs to the binding-protein-dependent transport system permease family
HHA22_RS22100	COG0640	Transcriptional regulator
HHA22_RS22135	COG0735	belongs to the Fur family
HHA22_RS22140	COG2207	Transcriptional regulator
HHA22_RS22155	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HHA22_RS22160	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HHA22_RS22165	COG0513	Belongs to the DEAD box helicase family
HHA22_RS22185	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HHA22_RS22190	COG2308	Evidence 4 Homologs of previously reported genes of
HHA22_RS22200	COG1305	Transglutaminase-like
HHA22_RS22220	COG3220	belongs to the UPF0276 family
HHA22_RS22235	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HHA22_RS22240	COG1950	PFAM Membrane protein of
HHA22_RS22250	COG0438	transferase activity, transferring glycosyl groups
HHA22_RS22265	COG0066	3-isopropylmalate dehydratase activity
HHA22_RS22280	COG0583	DNA-binding transcription factor activity
HHA22_RS22285	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HHA22_RS22295	COG1560	Kdo2-lipid A biosynthetic process
HHA22_RS22300	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HHA22_RS22310	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HHA22_RS22335	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HHA22_RS22340	COG1121	(ABC) transporter
HHA22_RS22345	COG0735	belongs to the Fur family
HHA22_RS22350	COG0523	cobalamin synthesis protein
HHA22_RS22360	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HHA22_RS22365	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HHA22_RS22375	COG2096	Adenosyltransferase
HHA22_RS22380	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HHA22_RS22385	COG0321	lipoyl(octanoyl) transferase activity
HHA22_RS22390	COG2921	Belongs to the UPF0250 family
HHA22_RS22400	COG1686	Belongs to the peptidase S11 family
HHA22_RS22420	COG1127	ABC transporter
HHA22_RS22425	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HHA22_RS22435	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HHA22_RS22450	COG0859	PFAM glycosyl transferase family 9
HHA22_RS22485	COG0477	Major facilitator Superfamily
HHA22_RS22495	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HHA22_RS22500	COG3568	Endonuclease Exonuclease Phosphatase
HHA22_RS22505	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HHA22_RS22535	COG0531	amino acid
HHA22_RS22540	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HHA22_RS22545	COG1956	GAF domain-containing protein
HHA22_RS22550	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HHA22_RS22555	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HHA22_RS22565	COG1129	ABC transporter
HHA22_RS22575	COG1172	Belongs to the binding-protein-dependent transport system permease family
HHA22_RS22585	COG1172	Belongs to the binding-protein-dependent transport system permease family
HHA22_RS22595	COG2186	Transcriptional regulator
HHA22_RS22600	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HHA22_RS22605	COG3842	ATPase activity
HHA22_RS22610	COG1175	transmembrane transport
HHA22_RS22660	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HHA22_RS22665	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HHA22_RS22685	COG0367	asparagine synthase
HHA22_RS22690	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HHA22_RS22695	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HHA22_RS22705	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HHA22_RS22720	COG2226	methyltransferase
HHA22_RS22725	COG0438	transferase activity, transferring glycosyl groups
HHA22_RS22730	COG0367	asparagine synthase
HHA22_RS22735	COG0367	asparagine synthase
HHA22_RS22750	COG2814	Major facilitator Superfamily
HHA22_RS22770	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HHA22_RS22775	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HHA22_RS22780	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HHA22_RS22790	COG1965	Belongs to the frataxin family
HHA22_RS22805	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HHA22_RS22810	COG1333	cytochrome c biogenesis protein
HHA22_RS22820	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HHA22_RS22835	COG4232	protein-disulfide reductase activity
HHA22_RS22840	COG1324	tolerance protein
HHA22_RS22850	COG0203	ribosomal protein L17
HHA22_RS22855	COG0202	RNA polymerase activity
HHA22_RS22860	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HHA22_RS22865	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HHA22_RS22870	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HHA22_RS22875	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HHA22_RS22880	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HHA22_RS22885	COG0201	protein transport
HHA22_RS22890	COG0200	Binds to the 23S rRNA
HHA22_RS22895	COG1841	ribosomal large subunit assembly
HHA22_RS22900	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HHA22_RS22905	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HHA22_RS22910	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HHA22_RS22915	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HHA22_RS22920	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HHA22_RS22925	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HHA22_RS22930	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HHA22_RS22935	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HHA22_RS22960	COG2267	carboxylic ester hydrolase activity
HHA22_RS22975	COG1131	(ABC) transporter
HHA22_RS22990	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HHA22_RS22995	COG0255	Belongs to the universal ribosomal protein uL29 family
HHA22_RS23000	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HHA22_RS23005	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HHA22_RS23010	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HHA22_RS23015	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HHA22_RS23020	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HHA22_RS23025	COG0089	rRNA binding
HHA22_RS23030	COG0088	Forms part of the polypeptide exit tunnel
HHA22_RS23035	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HHA22_RS23040	COG0051	transcription antitermination factor activity, RNA binding
HHA22_RS23045	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HHA22_RS23050	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HHA22_RS23055	COG0049	tRNA binding
HHA22_RS23060	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HHA22_RS23095	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HHA22_RS23100	COG0085	RNA polymerase activity
HHA22_RS23105	COG0222	ribosome binding
HHA22_RS23110	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HHA22_RS23115	COG0081	regulation of translation
HHA22_RS23120	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HHA22_RS23130	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HHA22_RS23140	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HHA22_RS23160	COG0252	asparaginase activity
HHA22_RS23165	COG1475	DNA binding
HHA22_RS23170	COG1192	Involved in chromosome partitioning
HHA22_RS23175	COG0357	Ribosomal RNA small subunit methyltransferase G
HHA22_RS23180	COG0445	tRNA wobble uridine modification
HHA22_RS23185	COG1278	Cold shock
HHA22_RS23190	COG0436	Aminotransferase
HHA22_RS23200	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HHA22_RS23205	COG0583	DNA-binding transcription factor activity
HHA22_RS23250	COG3181	Tripartite tricarboxylate transporter family receptor
HHA22_RS23255	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HHA22_RS23265	COG0179	Fumarylacetoacetate (FAA) hydrolase
HHA22_RS23275	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HHA22_RS23285	COG1505	serine-type exopeptidase activity
HHA22_RS23290	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HHA22_RS23300	COG0601	transmembrane transport
HHA22_RS23305	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HHA22_RS23310	COG0444	Belongs to the ABC transporter superfamily
HHA22_RS23315	COG4608	Belongs to the ABC transporter superfamily
HHA22_RS23320	COG1473	amidohydrolase
HHA22_RS23325	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HHA22_RS23330	COG0706	membrane insertase activity
HHA22_RS23335	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HHA22_RS23340	COG0594	ribonuclease P activity
HHA22_RS23345	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HHA22_RS23355	COG0477	Major facilitator Superfamily
HHA22_RS23365	COG0179	Fumarylacetoacetate (FAA) hydrolase
HHA22_RS23375	COG4133	protoheme IX ABC transporter activity
HHA22_RS23430	COG0583	DNA-binding transcription factor activity
HHA22_RS23535	COG4774	siderophore transport
HHA22_RS23560	COG3468	outer membrane autotransporter barrel domain protein
HHA22_RS23580	COG0840	transmembrane signaling receptor activity