locus-tag	class	description
ACR54_RS00005	COG0445	tRNA wobble uridine modification
ACR54_RS00010	COG0357	Ribosomal RNA small subunit methyltransferase G
ACR54_RS00015	COG1192	Involved in chromosome partitioning
ACR54_RS00020	COG1475	DNA binding
ACR54_RS00025	COG0252	asparaginase activity
ACR54_RS00045	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ACR54_RS00055	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ACR54_RS00065	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ACR54_RS00070	COG0081	regulation of translation
ACR54_RS00075	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ACR54_RS00080	COG0222	ribosome binding
ACR54_RS00085	COG0085	RNA polymerase activity
ACR54_RS00090	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ACR54_RS00125	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ACR54_RS00130	COG0049	tRNA binding
ACR54_RS00135	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ACR54_RS00140	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ACR54_RS00145	COG0051	transcription antitermination factor activity, RNA binding
ACR54_RS00150	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ACR54_RS00155	COG0088	Forms part of the polypeptide exit tunnel
ACR54_RS00160	COG0089	rRNA binding
ACR54_RS00165	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ACR54_RS00170	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ACR54_RS00175	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ACR54_RS00180	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ACR54_RS00185	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ACR54_RS00190	COG0255	Belongs to the universal ribosomal protein uL29 family
ACR54_RS00195	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ACR54_RS00210	COG1131	(ABC) transporter
ACR54_RS00225	COG2267	carboxylic ester hydrolase activity
ACR54_RS00250	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ACR54_RS00255	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ACR54_RS00260	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ACR54_RS00265	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ACR54_RS00270	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ACR54_RS00275	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ACR54_RS00280	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ACR54_RS00285	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ACR54_RS00290	COG1841	ribosomal large subunit assembly
ACR54_RS00295	COG0200	Binds to the 23S rRNA
ACR54_RS00300	COG0201	protein transport
ACR54_RS00305	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ACR54_RS00310	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ACR54_RS00315	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ACR54_RS00320	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ACR54_RS00325	COG0202	RNA polymerase activity
ACR54_RS00330	COG0203	ribosomal protein L17
ACR54_RS00340	COG1324	tolerance protein
ACR54_RS00345	COG4232	protein-disulfide reductase activity
ACR54_RS00360	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ACR54_RS00370	COG1333	cytochrome c biogenesis protein
ACR54_RS00375	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ACR54_RS00385	COG1965	Belongs to the frataxin family
ACR54_RS00395	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ACR54_RS00400	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ACR54_RS00405	COG0232	Belongs to the dGTPase family. Type 2 subfamily
ACR54_RS00425	COG2814	Major facilitator Superfamily
ACR54_RS00440	COG0367	asparagine synthase
ACR54_RS00445	COG0367	asparagine synthase
ACR54_RS00450	COG0438	transferase activity, transferring glycosyl groups
ACR54_RS00455	COG2226	methyltransferase
ACR54_RS00470	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ACR54_RS00480	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ACR54_RS00485	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ACR54_RS00490	COG0367	asparagine synthase
ACR54_RS00510	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ACR54_RS00515	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ACR54_RS00565	COG1175	transmembrane transport
ACR54_RS00570	COG3842	ATPase activity
ACR54_RS00575	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
ACR54_RS00580	COG2186	Transcriptional regulator
ACR54_RS00590	COG1172	Belongs to the binding-protein-dependent transport system permease family
ACR54_RS00600	COG1172	Belongs to the binding-protein-dependent transport system permease family
ACR54_RS00610	COG1129	ABC transporter
ACR54_RS00620	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
ACR54_RS00625	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ACR54_RS00630	COG1956	GAF domain-containing protein
ACR54_RS00635	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ACR54_RS00640	COG0531	amino acid
ACR54_RS00670	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ACR54_RS00675	COG3568	Endonuclease Exonuclease Phosphatase
ACR54_RS00680	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ACR54_RS00690	COG0477	Major facilitator Superfamily
ACR54_RS00725	COG0859	PFAM glycosyl transferase family 9
ACR54_RS00735	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
ACR54_RS00745	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ACR54_RS00750	COG1127	ABC transporter
ACR54_RS00770	COG1686	Belongs to the peptidase S11 family
ACR54_RS00780	COG2921	Belongs to the UPF0250 family
ACR54_RS00785	COG0321	lipoyl(octanoyl) transferase activity
ACR54_RS00790	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ACR54_RS00795	COG2096	Adenosyltransferase
ACR54_RS00805	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
ACR54_RS00810	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
ACR54_RS00820	COG0523	cobalamin synthesis protein
ACR54_RS00825	COG0735	belongs to the Fur family
ACR54_RS00835	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ACR54_RS00860	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
ACR54_RS00870	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ACR54_RS00875	COG1560	Kdo2-lipid A biosynthetic process
ACR54_RS00885	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ACR54_RS00890	COG0583	DNA-binding transcription factor activity
ACR54_RS00905	COG0066	3-isopropylmalate dehydratase activity
ACR54_RS00920	COG0438	transferase activity, transferring glycosyl groups
ACR54_RS00930	COG1950	PFAM Membrane protein of
ACR54_RS00935	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
ACR54_RS00950	COG3220	belongs to the UPF0276 family
ACR54_RS00970	COG1305	Transglutaminase-like
ACR54_RS00980	COG2308	Evidence 4 Homologs of previously reported genes of
ACR54_RS00985	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ACR54_RS01005	COG0513	Belongs to the DEAD box helicase family
ACR54_RS01010	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
ACR54_RS01015	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ACR54_RS01030	COG2207	Transcriptional regulator
ACR54_RS01035	COG0735	belongs to the Fur family
ACR54_RS01070	COG0640	Transcriptional regulator
ACR54_RS01175	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ACR54_RS01180	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ACR54_RS01185	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ACR54_RS01200	COG0758	DNA mediated transformation
ACR54_RS01215	COG1966	Carbon starvation protein
ACR54_RS01220	COG2879	small protein
ACR54_RS01225	COG1522	sequence-specific DNA binding
ACR54_RS01235	COG0242	peptide deformylase activity
ACR54_RS01240	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ACR54_RS01250	COG0546	phosphoglycolate phosphatase activity
ACR54_RS01265	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ACR54_RS01270	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ACR54_RS01300	COG1012	belongs to the aldehyde dehydrogenase family
ACR54_RS01305	COG0583	DNA-binding transcription factor activity
ACR54_RS01310	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ACR54_RS01340	COG2267	carboxylic ester hydrolase activity
ACR54_RS01345	COG2072	flavoprotein involved in K transport
ACR54_RS01350	COG1250	3-hydroxyacyl-CoA dehydrogenase
ACR54_RS01355	COG3181	Tripartite tricarboxylate transporter family receptor
ACR54_RS01360	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ACR54_RS01370	COG0583	DNA-binding transcription factor activity
ACR54_RS01375	COG2814	Major facilitator Superfamily
ACR54_RS01380	COG0583	DNA-binding transcription factor activity
ACR54_RS01390	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ACR54_RS01390	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ACR54_RS01400	COG5000	phosphorelay sensor kinase activity
ACR54_RS01405	COG2204	response regulator
ACR54_RS01410	COG0569	domain protein
ACR54_RS01415	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ACR54_RS01420	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
ACR54_RS01425	COG2226	methyltransferase
ACR54_RS01445	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ACR54_RS01450	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
ACR54_RS01455	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ACR54_RS01465	COG0588	phosphoglycerate mutase activity
ACR54_RS01470	COG4942	peptidase
ACR54_RS01475	COG0793	Belongs to the peptidase S41A family
ACR54_RS01480	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ACR54_RS01495	COG1012	belongs to the aldehyde dehydrogenase family
ACR54_RS01500	COG0861	Integral membrane protein TerC family
ACR54_RS01515	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
ACR54_RS01520	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ACR54_RS01520	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ACR54_RS01540	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ACR54_RS01545	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ACR54_RS01550	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ACR54_RS01555	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ACR54_RS01560	COG0142	geranyltranstransferase activity
ACR54_RS01670	COG0154	amidase activity
ACR54_RS01675	COG0683	leucine binding
ACR54_RS01705	COG0659	secondary active sulfate transmembrane transporter activity
ACR54_RS01725	COG1228	amidohydrolase
ACR54_RS01740	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ACR54_RS01745	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ACR54_RS01750	COG2890	protein-(glutamine-N5) methyltransferase activity
ACR54_RS01755	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
ACR54_RS01775	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ACR54_RS01780	COG0288	reversible hydration of carbon dioxide
ACR54_RS01800	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ACR54_RS01810	COG4829	muconolactone delta-isomerase
ACR54_RS01815	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
ACR54_RS01825	COG1414	Transcriptional regulator
ACR54_RS01830	COG1028	Short-chain dehydrogenase reductase Sdr
ACR54_RS01835	COG2031	fatty acid transporter
ACR54_RS01840	COG1250	3-hydroxyacyl-CoA dehydrogenase
ACR54_RS01845	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
ACR54_RS01850	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ACR54_RS01870	COG0129	dihydroxy-acid dehydratase activity
ACR54_RS01875	COG3539	Fimbrial protein
ACR54_RS01885	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
ACR54_RS01905	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ACR54_RS01910	COG0583	DNA-binding transcription factor activity
ACR54_RS01915	COG0628	permease
ACR54_RS01920	COG5285	phytanoyl-CoA dioxygenase
ACR54_RS01925	COG1595	DNA-templated transcription, initiation
ACR54_RS01930	COG3712	iron ion homeostasis
ACR54_RS01935	COG4774	siderophore transport
ACR54_RS01940	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ACR54_RS02020	COG0436	Aminotransferase
ACR54_RS02030	COG0235	Class ii aldolase
ACR54_RS02045	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ACR54_RS02050	COG0022	dehydrogenase e1 component
ACR54_RS02055	COG0509	glycine decarboxylation via glycine cleavage system
ACR54_RS02080	COG3284	Transcriptional regulator
ACR54_RS02090	COG1819	glycosyl
ACR54_RS02125	COG2233	PERMEase
ACR54_RS02130	COG0326	Molecular chaperone. Has ATPase activity
ACR54_RS02135	COG2271	Major facilitator Superfamily
ACR54_RS02140	COG4948	Mandelate Racemase Muconate Lactonizing
ACR54_RS02145	COG0800	Aldolase
ACR54_RS02150	COG3734	2-keto-3-deoxy-galactonokinase
ACR54_RS02155	COG1414	Transcriptional regulator
ACR54_RS02165	COG4336	lyase activity
ACR54_RS02195	COG0625	glutathione transferase activity
ACR54_RS02210	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ACR54_RS02215	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ACR54_RS02225	COG1178	ABC-type Fe3 transport system permease component
ACR54_RS02230	COG3842	ATPase activity
ACR54_RS02235	COG0583	DNA-binding transcription factor activity
ACR54_RS02240	COG0560	Phosphoserine phosphatase
ACR54_RS02245	COG1652	LysM domain
ACR54_RS02260	COG0220	tRNA (guanine-N7-)-methyltransferase activity
ACR54_RS02270	COG0583	DNA-binding transcription factor activity
ACR54_RS02275	COG1012	belongs to the aldehyde dehydrogenase family
ACR54_RS02300	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ACR54_RS02305	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ACR54_RS02310	COG0277	FAD linked oxidase domain protein
ACR54_RS02325	COG0582	viral genome integration into host DNA
ACR54_RS02340	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ACR54_RS02345	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ACR54_RS02350	COG3135	benzoate transporter
ACR54_RS02405	COG0024	Methionine aminopeptidase
ACR54_RS02420	COG2814	Major facilitator Superfamily
ACR54_RS02425	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ACR54_RS02435	COG1280	lysine exporter protein (LysE YggA)
ACR54_RS02450	COG1280	lysine exporter protein (LysE YggA)
ACR54_RS02460	COG0583	DNA-binding transcription factor activity
ACR54_RS02475	COG0519	Catalyzes the synthesis of GMP from XMP
ACR54_RS02475	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ACR54_RS02480	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ACR54_RS02490	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ACR54_RS02495	COG0583	DNA-binding transcription factor activity
ACR54_RS02525	COG1917	Cupin 2, conserved barrel domain protein
ACR54_RS02540	COG1024	Enoyl-CoA hydratase
ACR54_RS02630	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ACR54_RS02780	COG0798	PFAM Bile acid sodium symporter
ACR54_RS02790	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ACR54_RS02895	COG0583	DNA-binding transcription factor activity
ACR54_RS02900	COG3181	Tripartite tricarboxylate transporter family receptor
ACR54_RS02905	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
ACR54_RS02910	COG1028	Short-chain dehydrogenase reductase Sdr
ACR54_RS02915	COG3181	Tripartite tricarboxylate transporter family receptor
ACR54_RS02930	COG1028	Short-chain dehydrogenase reductase Sdr
ACR54_RS02945	COG1960	acyl-CoA dehydrogenase activity
ACR54_RS02955	COG1024	Enoyl-CoA hydratase
ACR54_RS02960	COG3386	PFAM SMP-30 Gluconolaconase
ACR54_RS02965	COG0583	DNA-binding transcription factor activity
ACR54_RS02970	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACR54_RS02975	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ACR54_RS02975	COG0426	domain, Protein
ACR54_RS03020	COG2072	flavoprotein involved in K transport
ACR54_RS03025	COG0583	DNA-binding transcription factor activity
ACR54_RS03030	COG1028	Short-chain dehydrogenase reductase Sdr
ACR54_RS03035	COG1309	transcriptional regulator
ACR54_RS03070	COG1309	transcriptional regulator
ACR54_RS03075	COG1960	acyl-CoA dehydrogenase activity
ACR54_RS03080	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ACR54_RS03100	COG0625	glutathione transferase activity
ACR54_RS03105	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
ACR54_RS03110	COG0583	DNA-binding transcription factor activity
ACR54_RS03120	COG0765	amino acid transport
ACR54_RS03125	COG0765	amino acid transport
ACR54_RS03130	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ACR54_RS03160	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ACR54_RS03175	COG2423	ornithine cyclodeaminase activity
ACR54_RS03195	COG1073	alpha beta
ACR54_RS03195	COG2226	methyltransferase
ACR54_RS03210	COG0411	ABC transporter
ACR54_RS03230	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ACR54_RS03235	COG2084	Dehydrogenase
ACR54_RS03250	COG1028	Short-chain dehydrogenase reductase Sdr
ACR54_RS03275	COG1177	transmembrane transport
ACR54_RS03280	COG1176	ABC-type spermidine putrescine transport system, permease component I
ACR54_RS03285	COG3842	ATPase activity
ACR54_RS03300	COG0010	Belongs to the arginase family
ACR54_RS03330	COG1054	Belongs to the UPF0176 family
ACR54_RS03335	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ACR54_RS03335	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ACR54_RS03345	COG0489	protein tyrosine kinase activity
ACR54_RS03360	COG0717	Belongs to the dCTP deaminase family
ACR54_RS03365	COG0456	acetyltransferase
ACR54_RS03365	COG1214	PFAM Peptidase M22, glycoprotease
ACR54_RS03380	COG2081	HI0933 family
ACR54_RS03395	COG0559	Belongs to the binding-protein-dependent transport system permease family
ACR54_RS03420	COG0371	Dehydrogenase
ACR54_RS03430	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ACR54_RS03435	COG0509	glycine decarboxylation via glycine cleavage system
ACR54_RS03440	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ACR54_RS03440	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ACR54_RS03445	COG5339	Protein conserved in bacteria
ACR54_RS03460	COG4172	Belongs to the ABC transporter superfamily
ACR54_RS03465	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ACR54_RS03470	COG0601	transmembrane transport
ACR54_RS03475	COG0747	negative chemotaxis
ACR54_RS03490	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ACR54_RS03495	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ACR54_RS03515	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
ACR54_RS03520	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ACR54_RS03525	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
ACR54_RS03540	COG0438	transferase activity, transferring glycosyl groups
ACR54_RS03555	COG0438	transferase activity, transferring glycosyl groups
ACR54_RS03560	COG0438	transferase activity, transferring glycosyl groups
ACR54_RS03565	COG0166	Belongs to the GPI family
ACR54_RS03580	COG0277	FAD linked oxidase domain protein
ACR54_RS03585	COG0745	RESPONSE REGULATOR receiver
ACR54_RS03590	COG5002	protein histidine kinase activity
ACR54_RS03590	COG5000	phosphorelay sensor kinase activity
ACR54_RS03595	COG2186	Transcriptional regulator
ACR54_RS03600	COG1368	sulfuric ester hydrolase activity
ACR54_RS03610	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
ACR54_RS03625	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ACR54_RS03635	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ACR54_RS03645	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
ACR54_RS03650	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ACR54_RS03660	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ACR54_RS03665	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
ACR54_RS03670	COG0193	aminoacyl-tRNA hydrolase activity
ACR54_RS03680	COG0012	GTP binding
ACR54_RS03700	COG2814	Major facilitator Superfamily
ACR54_RS03705	COG3181	Tripartite tricarboxylate transporter family receptor
ACR54_RS03725	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ACR54_RS03730	COG1024	Enoyl-CoA hydratase
ACR54_RS03735	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ACR54_RS03780	COG3135	benzoate transporter
ACR54_RS03785	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ACR54_RS03790	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ACR54_RS03795	COG0742	ribosomal rna small subunit methyltransferase
ACR54_RS03810	COG3639	organic phosphonate transmembrane transporter activity
ACR54_RS03815	COG3639	organic phosphonate transmembrane transporter activity
ACR54_RS03820	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
ACR54_RS03895	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ACR54_RS03900	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ACR54_RS03910	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ACR54_RS03920	COG0284	orotidine-5'-phosphate decarboxylase activity
ACR54_RS03925	COG1252	NADH dehydrogenase
ACR54_RS03930	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
ACR54_RS03940	COG0459	protein refolding
ACR54_RS03945	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ACR54_RS03965	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ACR54_RS03970	COG1028	Short-chain dehydrogenase reductase Sdr
ACR54_RS03995	COG1175	transmembrane transport
ACR54_RS04020	COG2226	methyltransferase
ACR54_RS04020	COG1073	alpha beta
ACR54_RS04030	COG0583	DNA-binding transcription factor activity
ACR54_RS04045	COG0459	protein refolding
ACR54_RS04080	COG3971	2-oxopent-4-enoate hydratase activity
ACR54_RS04090	COG4569	acetaldehyde dehydrogenase (acetylating) activity
ACR54_RS04095	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ACR54_RS04105	COG0657	acetylesterase activity
ACR54_RS04130	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ACR54_RS04145	COG1595	DNA-templated transcription, initiation
ACR54_RS04155	COG4774	siderophore transport
ACR54_RS04170	COG0583	DNA-binding transcription factor activity
ACR54_RS04180	COG1595	DNA-templated transcription, initiation
ACR54_RS04190	COG0513	Belongs to the DEAD box helicase family
ACR54_RS04195	COG1802	Transcriptional regulator
ACR54_RS04200	COG1802	Transcriptional regulator
ACR54_RS04205	COG0028	Belongs to the TPP enzyme family
ACR54_RS04230	COG0683	leucine binding
ACR54_RS04245	COG1028	Short-chain dehydrogenase reductase Sdr
ACR54_RS04255	COG1028	Short-chain dehydrogenase reductase Sdr
ACR54_RS04260	COG1960	acyl-CoA dehydrogenase activity
ACR54_RS04280	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ACR54_RS04290	COG3485	protocatechuate 3,4-dioxygenase
ACR54_RS04295	COG3485	protocatechuate 3,4-dioxygenase
ACR54_RS04300	COG0583	DNA-binding transcription factor activity
ACR54_RS04305	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
ACR54_RS04310	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
ACR54_RS04315	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ACR54_RS04320	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ACR54_RS04325	COG1414	Transcriptional regulator
ACR54_RS04330	COG0583	DNA-binding transcription factor activity
ACR54_RS04340	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ACR54_RS04345	COG0477	Major facilitator Superfamily
ACR54_RS04350	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ACR54_RS04375	COG4566	intracellular signal transduction
ACR54_RS04380	COG2205	protein histidine kinase activity
ACR54_RS04380	COG4191	Histidine kinase
ACR54_RS04380	COG0745	RESPONSE REGULATOR receiver
ACR54_RS04390	COG4608	Belongs to the ABC transporter superfamily
ACR54_RS04395	COG0444	Belongs to the ABC transporter superfamily
ACR54_RS04400	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ACR54_RS04405	COG0601	transmembrane transport
ACR54_RS04410	COG0747	negative chemotaxis
ACR54_RS04415	COG1802	Transcriptional regulator
ACR54_RS04420	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ACR54_RS04450	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ACR54_RS04465	COG2832	Protein of unknown function (DUF454)
ACR54_RS04485	COG1686	Belongs to the peptidase S11 family
ACR54_RS04495	COG3685	Protein conserved in bacteria
ACR54_RS04505	COG1368	sulfuric ester hydrolase activity
ACR54_RS04510	COG0154	amidase activity
ACR54_RS04520	COG1137	ATPase activity
ACR54_RS04545	COG1024	Enoyl-CoA hydratase
ACR54_RS04555	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ACR54_RS04560	COG1802	Transcriptional regulator
ACR54_RS04565	COG0583	DNA-binding transcription factor activity
ACR54_RS04570	COG1215	transferase activity, transferring glycosyl groups
ACR54_RS04580	COG0601	transmembrane transport
ACR54_RS04585	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ACR54_RS04590	COG0444	Belongs to the ABC transporter superfamily
ACR54_RS04595	COG4608	Belongs to the ABC transporter superfamily
ACR54_RS04610	COG0488	(ABC) transporter
ACR54_RS04625	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
ACR54_RS04630	COG2894	cell division
ACR54_RS04635	COG0850	regulation of cytokinetic process
ACR54_RS04640	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ACR54_RS04650	COG1294	oxidase, subunit
ACR54_RS04670	COG0514	ATP-dependent DNA helicase (RecQ)
ACR54_RS04675	COG2255	four-way junction helicase activity
ACR54_RS04680	COG0702	epimerase
ACR54_RS04690	COG0632	four-way junction helicase activity
ACR54_RS04695	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
ACR54_RS04715	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ACR54_RS04725	COG0006	proline dipeptidase activity
ACR54_RS04740	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ACR54_RS04760	COG4783	chaperone-mediated protein folding
ACR54_RS04765	COG0429	hydrolase of the alpha beta-hydrolase fold
ACR54_RS04790	COG0513	Belongs to the DEAD box helicase family
ACR54_RS04805	COG1546	Belongs to the CinA family
ACR54_RS04805	COG1058	Belongs to the CinA family
ACR54_RS04810	COG1414	Transcriptional regulator
ACR54_RS04825	COG0167	dihydroorotate dehydrogenase activity
ACR54_RS04830	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
ACR54_RS04835	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
ACR54_RS04845	COG0583	DNA-binding transcription factor activity
ACR54_RS04880	COG0523	cobalamin synthesis protein
ACR54_RS04885	COG1335	isochorismatase
ACR54_RS04890	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ACR54_RS04895	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ACR54_RS04900	COG1802	Transcriptional regulator
ACR54_RS04905	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
ACR54_RS04925	COG1280	lysine exporter protein (LysE YggA)
ACR54_RS04930	COG2828	Protein conserved in bacteria
ACR54_RS04960	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ACR54_RS04985	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ACR54_RS04990	COG0735	belongs to the Fur family
ACR54_RS04995	COG0497	DNA recombination
ACR54_RS05000	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ACR54_RS05005	COG1420	regulation of RNA biosynthetic process
ACR54_RS05010	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ACR54_RS05020	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ACR54_RS05030	COG0443	Heat shock 70 kDa protein
ACR54_RS05035	COG0484	heat shock protein binding
ACR54_RS05040	COG0612	Peptidase, M16
ACR54_RS05055	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ACR54_RS05080	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ACR54_RS05095	COG0745	RESPONSE REGULATOR receiver
ACR54_RS05100	COG2205	protein histidine kinase activity
ACR54_RS05105	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
ACR54_RS05110	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
ACR54_RS05115	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
ACR54_RS05130	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ACR54_RS05140	COG1193	negative regulation of DNA recombination
ACR54_RS05145	COG0492	ferredoxin-NADP+ reductase activity
ACR54_RS05150	COG1674	ftsk spoiiie
ACR54_RS05155	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
ACR54_RS05165	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
ACR54_RS05170	COG0517	IMP dehydrogenase activity
ACR54_RS05170	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ACR54_RS05190	COG0601	transmembrane transport
ACR54_RS05205	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ACR54_RS05215	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ACR54_RS05225	COG3447	MASE1 domain protein
ACR54_RS05225	COG5001	Diguanylate cyclase
ACR54_RS05225	COG5002	protein histidine kinase activity
ACR54_RS05235	COG2095	MarC family integral membrane protein
ACR54_RS05290	COG3181	Tripartite tricarboxylate transporter family receptor
ACR54_RS05295	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
ACR54_RS05300	COG4638	Rieske (2fe-2S)
ACR54_RS05305	COG2186	Transcriptional regulator
ACR54_RS05320	COG1309	transcriptional regulator
ACR54_RS05345	COG1028	Short-chain dehydrogenase reductase Sdr
ACR54_RS05350	COG3022	response to hydroperoxide
ACR54_RS05355	COG1289	transmembrane transporter activity
ACR54_RS05360	COG0028	Belongs to the TPP enzyme family
ACR54_RS05365	COG0440	acetolactate synthase activity
ACR54_RS05370	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ACR54_RS05375	COG1183	phosphatidylcholine synthase activity
ACR54_RS05385	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ACR54_RS05390	COG1185	polyribonucleotide nucleotidyltransferase activity
ACR54_RS05420	COG0583	DNA-binding transcription factor activity
ACR54_RS05425	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ACR54_RS05450	COG4221	oxidoreductase activity
ACR54_RS05450	COG3321	synthase
ACR54_RS05450	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ACR54_RS05450	COG0604	alcohol dehydrogenase
ACR54_RS05455	COG0149	triose-phosphate isomerase activity
ACR54_RS05460	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ACR54_RS05465	COG0438	transferase activity, transferring glycosyl groups
ACR54_RS05470	COG4607	ABC-type enterochelin transport system periplasmic component
ACR54_RS05475	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ACR54_RS05480	COG4605	iron ion homeostasis
ACR54_RS05485	COG4604	ABC transporter, ATP-binding protein
ACR54_RS05505	COG0179	Fumarylacetoacetate (FAA) hydrolase
ACR54_RS05515	COG1028	Short-chain dehydrogenase reductase Sdr
ACR54_RS05530	COG2186	Transcriptional regulator
ACR54_RS05535	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ACR54_RS05540	COG1960	acyl-CoA dehydrogenase activity
ACR54_RS05570	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ACR54_RS05590	COG1414	Transcriptional regulator
ACR54_RS05595	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
ACR54_RS05600	COG2202	Pas domain
ACR54_RS05600	COG2199	diguanylate cyclase activity
ACR54_RS05600	COG2200	EAL domain
ACR54_RS05640	COG4172	Belongs to the ABC transporter superfamily
ACR54_RS05670	COG1012	belongs to the aldehyde dehydrogenase family
ACR54_RS05680	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
ACR54_RS05680	COG3608	succinylglutamate desuccinylase aspartoacylase
ACR54_RS05685	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ACR54_RS05705	COG2020	methyltransferase activity
ACR54_RS05720	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ACR54_RS05735	COG0251	oxidation-reduction process
ACR54_RS05745	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ACR54_RS05755	COG0765	amino acid transport
ACR54_RS05760	COG1126	abc transporter atp-binding protein
ACR54_RS05770	COG1176	ABC-type spermidine putrescine transport system, permease component I
ACR54_RS05775	COG1177	transmembrane transport
ACR54_RS05780	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ACR54_RS05785	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ACR54_RS05795	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ACR54_RS05795	COG0604	alcohol dehydrogenase
ACR54_RS05795	COG4221	oxidoreductase activity
ACR54_RS05795	COG3321	synthase
ACR54_RS05800	COG3842	ATPase activity
ACR54_RS05805	COG2072	flavoprotein involved in K transport
ACR54_RS05815	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ACR54_RS05825	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ACR54_RS05855	COG0583	DNA-binding transcription factor activity
ACR54_RS05860	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ACR54_RS05885	COG2321	neutral zinc metallopeptidase
ACR54_RS05890	COG0009	L-threonylcarbamoyladenylate synthase
ACR54_RS05895	COG1994	Peptidase M50
ACR54_RS05900	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ACR54_RS05905	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
ACR54_RS05915	COG2850	peptidyl-arginine hydroxylation
ACR54_RS05920	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ACR54_RS05940	COG3360	Dodecin
ACR54_RS05975	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
ACR54_RS05985	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ACR54_RS06010	COG0668	transmembrane transport
ACR54_RS06025	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
ACR54_RS06030	COG0483	inositol monophosphate 1-phosphatase activity
ACR54_RS06035	COG1253	flavin adenine dinucleotide binding
ACR54_RS06040	COG1968	undecaprenyl-diphosphatase activity
ACR54_RS06045	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ACR54_RS06050	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ACR54_RS06060	COG0215	cysteine-tRNA ligase activity
ACR54_RS06070	COG0825	malonyl-CoA metabolic process
ACR54_RS06075	COG0037	tRNA processing
ACR54_RS06090	COG1132	(ABC) transporter
ACR54_RS06105	COG2814	Major facilitator Superfamily
ACR54_RS06110	COG4772	TonB-dependent receptor
ACR54_RS06120	COG4993	Dehydrogenase
ACR54_RS06140	COG1414	Transcriptional regulator
ACR54_RS06145	COG1832	CoA-binding protein
ACR54_RS06155	COG0251	oxidation-reduction process
ACR54_RS06180	COG1902	pentaerythritol trinitrate reductase activity
ACR54_RS06190	COG0318	PFAM AMP-dependent synthetase and ligase
ACR54_RS06205	COG0183	Belongs to the thiolase family
ACR54_RS06210	COG1250	3-hydroxyacyl-CoA dehydrogenase
ACR54_RS06210	COG1024	Enoyl-CoA hydratase
ACR54_RS06215	COG2067	long-chain fatty acid transport protein
ACR54_RS06220	COG1250	3-hydroxyacyl-CoA dehydrogenase
ACR54_RS06220	COG1024	Enoyl-CoA hydratase
ACR54_RS06230	COG1960	acyl-CoA dehydrogenase activity
ACR54_RS06235	COG1309	transcriptional regulator
ACR54_RS06240	COG1045	serine acetyltransferase
ACR54_RS06250	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
ACR54_RS06260	COG1012	belongs to the aldehyde dehydrogenase family
ACR54_RS06265	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ACR54_RS06280	COG0210	DNA helicase
ACR54_RS06285	COG0598	Magnesium transport protein CorA
ACR54_RS06295	COG0747	negative chemotaxis
ACR54_RS06300	COG0601	transmembrane transport
ACR54_RS06305	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ACR54_RS06310	COG4172	Belongs to the ABC transporter superfamily
ACR54_RS06320	COG0583	DNA-binding transcription factor activity
ACR54_RS06325	COG1380	Effector of murein hydrolase LrgA
ACR54_RS06330	COG1346	cytolysis
ACR54_RS06345	COG0783	Belongs to the Dps family
ACR54_RS06370	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
ACR54_RS06380	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ACR54_RS06385	COG1845	cytochrome c oxidase, subunit III
ACR54_RS06390	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
ACR54_RS06420	COG1666	GTP binding
ACR54_RS06430	COG1129	ABC transporter
ACR54_RS06480	COG1028	Short-chain dehydrogenase reductase Sdr
ACR54_RS06485	COG5006	permease, DMT superfamily
ACR54_RS06505	COG2264	protein methyltransferase activity
ACR54_RS06520	COG3383	formate dehydrogenase (NAD+) activity
ACR54_RS06540	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ACR54_RS06545	COG0746	molybdenum cofactor guanylyltransferase activity
ACR54_RS06550	COG0303	'Molybdopterin
ACR54_RS06555	COG0521	Mo-molybdopterin cofactor biosynthetic process
ACR54_RS06560	COG0314	molybdopterin synthase activity
ACR54_RS06570	COG0315	cyclic pyranopterin monophosphate synthase activity
ACR54_RS06580	COG0412	Dienelactone hydrolase
ACR54_RS06590	COG0678	peroxiredoxin activity
ACR54_RS06605	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ACR54_RS06615	COG0542	response to heat
ACR54_RS06625	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
ACR54_RS06635	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ACR54_RS06640	COG1477	protein flavinylation
ACR54_RS06665	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ACR54_RS06670	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
ACR54_RS06670	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
ACR54_RS06675	COG1562	ergosterol biosynthetic process
ACR54_RS06685	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ACR54_RS06690	COG1028	Short-chain dehydrogenase reductase Sdr
ACR54_RS06725	COG0254	rRNA binding
ACR54_RS06730	COG3483	tryptophan 2,3-dioxygenase activity
ACR54_RS06735	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
ACR54_RS06740	COG2003	Belongs to the UPF0758 family
ACR54_RS06750	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ACR54_RS06755	COG0625	glutathione transferase activity
ACR54_RS06785	COG0523	cobalamin synthesis protein
ACR54_RS06790	COG0583	DNA-binding transcription factor activity
ACR54_RS06800	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
ACR54_RS06805	COG1187	pseudouridine synthase activity
ACR54_RS06810	COG0779	Required for maturation of 30S ribosomal subunits
ACR54_RS06815	COG0195	Participates in both transcription termination and antitermination
ACR54_RS06815	COG2251	uridine kinase activity
ACR54_RS06820	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ACR54_RS06825	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ACR54_RS06830	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ACR54_RS06835	COG1217	gtp-binding protein TYPA
ACR54_RS06855	COG1802	Transcriptional regulator
ACR54_RS06865	COG1024	Enoyl-CoA hydratase
ACR54_RS06870	COG0318	PFAM AMP-dependent synthetase and ligase
ACR54_RS06880	COG2032	superoxide dismutase activity
ACR54_RS06885	COG0667	Aldo Keto reductase
ACR54_RS06895	COG4120	Belongs to the binding-protein-dependent transport system permease family
ACR54_RS06905	COG0725	ABC transporter, periplasmic molybdate-binding protein
ACR54_RS06910	COG4149	molybdate abc transporter
ACR54_RS06915	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
ACR54_RS06935	COG0745	RESPONSE REGULATOR receiver
ACR54_RS06940	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ACR54_RS06945	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ACR54_RS06955	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
ACR54_RS06960	COG0736	holo-[acyl-carrier-protein] synthase activity
ACR54_RS06965	COG1472	Belongs to the glycosyl hydrolase 3 family
ACR54_RS06975	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ACR54_RS06985	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
ACR54_RS06985	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
ACR54_RS06990	COG2224	Isocitrate lyase
ACR54_RS06995	COG4106	trans-aconitate 2-methyltransferase activity
ACR54_RS06995	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
ACR54_RS07005	COG0156	8-amino-7-oxononanoate synthase activity
ACR54_RS07010	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ACR54_RS07015	COG2217	Heavy metal translocating P-type atpase
ACR54_RS07025	COG3278	Belongs to the heme-copper respiratory oxidase family
ACR54_RS07045	COG0348	domain, Protein
ACR54_RS07060	COG1846	Transcriptional regulator
ACR54_RS07065	COG1764	response to oxidative stress
ACR54_RS07070	COG1131	(ABC) transporter
ACR54_RS07075	COG0842	Transport permease protein
ACR54_RS07080	COG0628	permease
ACR54_RS07090	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
ACR54_RS07100	COG2814	Major facilitator Superfamily
ACR54_RS07140	COG0583	DNA-binding transcription factor activity
ACR54_RS07145	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACR54_RS07155	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ACR54_RS07160	COG0444	Belongs to the ABC transporter superfamily
ACR54_RS07165	COG4608	Belongs to the ABC transporter superfamily
ACR54_RS07185	COG2814	Major facilitator Superfamily
ACR54_RS07195	COG3530	Putative quorum-sensing-regulated virulence factor
ACR54_RS07200	COG0583	DNA-binding transcription factor activity
ACR54_RS07210	COG0494	nUDIX hydrolase
ACR54_RS07220	COG0697	spore germination
ACR54_RS07225	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ACR54_RS07275	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ACR54_RS07280	COG1702	phosphate starvation-inducible protein PhoH
ACR54_RS07285	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ACR54_RS07290	COG4535	Mg2 and Co2 transporter CorC
ACR54_RS07295	COG0815	Transfers the fatty acyl group on membrane lipoproteins
ACR54_RS07300	COG0667	Aldo Keto reductase
ACR54_RS07330	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ACR54_RS07335	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ACR54_RS07340	COG1862	Preprotein translocase
ACR54_RS07345	COG0343	queuine tRNA-ribosyltransferase activity
ACR54_RS07350	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
ACR54_RS07355	COG2027	D-alanyl-D-alanine carboxypeptidase
ACR54_RS07360	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ACR54_RS07365	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ACR54_RS07365	COG1648	precorrin-2 dehydrogenase activity
ACR54_RS07375	COG4575	ribosome binding
ACR54_RS07390	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
ACR54_RS07395	COG0741	lytic transglycosylase activity
ACR54_RS07400	COG0436	Aminotransferase
ACR54_RS07410	COG0281	malic enzyme
ACR54_RS07410	COG0280	phosphate acetyltransferase
ACR54_RS07425	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ACR54_RS07430	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ACR54_RS07435	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ACR54_RS07440	COG0126	phosphoglycerate kinase activity
ACR54_RS07450	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
ACR54_RS07455	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ACR54_RS07475	COG0625	glutathione transferase activity
ACR54_RS07520	COG0306	phosphate transporter
ACR54_RS07525	COG0521	Mo-molybdopterin cofactor biosynthetic process
ACR54_RS07535	COG0739	heme binding
ACR54_RS07545	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ACR54_RS07550	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
ACR54_RS07555	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
ACR54_RS07560	COG3639	organic phosphonate transmembrane transporter activity
ACR54_RS07565	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
ACR54_RS07575	COG3454	Phosphonate metabolism
ACR54_RS07580	COG2188	Transcriptional regulator
ACR54_RS07585	COG3624	Phosphonate C-P lyase system protein PhnG
ACR54_RS07595	COG3626	phosphonate metabolism
ACR54_RS07600	COG3627	carbon phosphorus lyase activity
ACR54_RS07605	COG4107	phosphonate C-P lyase system protein PhnK
ACR54_RS07610	COG4778	phosphonate C-P lyase system protein PhnL
ACR54_RS07615	COG3454	Phosphonate metabolism
ACR54_RS07645	COG0456	acetyltransferase
ACR54_RS07650	COG1301	dicarboxylic acid transport
ACR54_RS07660	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ACR54_RS07675	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ACR54_RS07680	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ACR54_RS07685	COG0009	L-threonylcarbamoyladenylate synthase
ACR54_RS07690	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ACR54_RS07705	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ACR54_RS07710	COG0765	amino acid transport
ACR54_RS07715	COG1126	abc transporter atp-binding protein
ACR54_RS07720	COG0028	Belongs to the TPP enzyme family
ACR54_RS07730	COG1960	acyl-CoA dehydrogenase activity
ACR54_RS07735	COG0028	Belongs to the TPP enzyme family
ACR54_RS07740	COG0583	DNA-binding transcription factor activity
ACR54_RS07745	COG4974	Belongs to the 'phage' integrase family
ACR54_RS07755	COG0693	protein deglycase activity
ACR54_RS07765	COG1686	Belongs to the peptidase S11 family
ACR54_RS07785	COG1074	ATP-dependent DNA helicase activity
ACR54_RS07790	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ACR54_RS07795	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
ACR54_RS07800	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ACR54_RS07805	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ACR54_RS07810	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ACR54_RS07820	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ACR54_RS07825	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ACR54_RS07830	COG0505	Belongs to the CarA family
ACR54_RS07835	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ACR54_RS07845	COG4221	oxidoreductase activity
ACR54_RS07850	COG0406	alpha-ribazole phosphatase activity
ACR54_RS07880	COG2233	PERMEase
ACR54_RS07885	COG3620	sequence-specific DNA binding
ACR54_RS07890	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ACR54_RS07900	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
ACR54_RS07905	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ACR54_RS07915	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ACR54_RS07950	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ACR54_RS07975	COG0701	Predicted permease
ACR54_RS08010	COG3181	Tripartite tricarboxylate transporter family receptor
ACR54_RS08015	COG0372	Belongs to the citrate synthase family
ACR54_RS08020	COG0583	DNA-binding transcription factor activity
ACR54_RS08030	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ACR54_RS08035	COG1960	acyl-CoA dehydrogenase activity
ACR54_RS08040	COG1960	acyl-CoA dehydrogenase activity
ACR54_RS08050	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ACR54_RS08065	COG1028	Short-chain dehydrogenase reductase Sdr
ACR54_RS08070	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ACR54_RS08120	COG1024	Enoyl-CoA hydratase
ACR54_RS08135	COG2030	dehydratase
ACR54_RS08145	COG3181	Tripartite tricarboxylate transporter family receptor
ACR54_RS08170	COG3307	-O-antigen
ACR54_RS08180	COG1215	transferase activity, transferring glycosyl groups
ACR54_RS08195	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
ACR54_RS08235	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ACR54_RS08255	COG0003	Pfam Anion-transporting ATPase
ACR54_RS08260	COG1215	transferase activity, transferring glycosyl groups
ACR54_RS08265	COG1215	transferase activity, transferring glycosyl groups
ACR54_RS08270	COG1215	transferase activity, transferring glycosyl groups
ACR54_RS08275	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
ACR54_RS08280	COG0457	Tetratricopeptide repeat
ACR54_RS08310	COG0583	DNA-binding transcription factor activity
ACR54_RS08315	COG1028	Short-chain dehydrogenase reductase Sdr
ACR54_RS08330	COG3181	Tripartite tricarboxylate transporter family receptor
ACR54_RS08335	COG3246	L-lysine catabolic process to acetate
ACR54_RS08345	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ACR54_RS08370	COG4774	siderophore transport
ACR54_RS08375	COG3712	iron ion homeostasis
ACR54_RS08380	COG1595	DNA-templated transcription, initiation
ACR54_RS08385	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
ACR54_RS08390	COG2146	nitrite reductase [NAD(P)H] activity
ACR54_RS08395	COG0583	DNA-binding transcription factor activity
ACR54_RS08405	COG4638	Rieske (2fe-2S)
ACR54_RS08410	COG2267	carboxylic ester hydrolase activity
ACR54_RS08415	COG4166	transmembrane transport
ACR54_RS08420	COG0601	transmembrane transport
ACR54_RS08430	COG4172	Belongs to the ABC transporter superfamily
ACR54_RS08440	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ACR54_RS08450	COG0583	DNA-binding transcription factor activity
ACR54_RS08465	COG3181	Tripartite tricarboxylate transporter family receptor
ACR54_RS08470	COG2188	Transcriptional regulator
ACR54_RS08505	COG0811	peptide transport
ACR54_RS08540	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ACR54_RS08565	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ACR54_RS08585	COG0747	negative chemotaxis
ACR54_RS08590	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
ACR54_RS08605	COG1028	Short-chain dehydrogenase reductase Sdr
ACR54_RS08610	COG0500	methyltransferase
ACR54_RS08640	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ACR54_RS08675	COG0540	Belongs to the ATCase OTCase family
ACR54_RS08680	COG2974	May be involved in recombination
ACR54_RS08705	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ACR54_RS08710	COG2137	regulation of response to DNA damage stimulus
ACR54_RS08720	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ACR54_RS08730	COG0045	succinate-CoA ligase (ADP-forming) activity
ACR54_RS08735	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ACR54_RS08740	COG0861	Integral membrane protein TerC family
ACR54_RS08745	COG0861	Integral membrane protein TerC family
ACR54_RS08755	COG0181	hydroxymethylbilane synthase activity
ACR54_RS08785	COG1028	Short-chain dehydrogenase reductase Sdr
ACR54_RS08800	COG1028	Short-chain dehydrogenase reductase Sdr
ACR54_RS08840	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ACR54_RS08875	COG1450	Type ii and iii secretion system protein
ACR54_RS08905	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ACR54_RS08915	COG1295	ribonuclease BN
ACR54_RS08925	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
ACR54_RS08935	COG2205	protein histidine kinase activity
ACR54_RS08945	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ACR54_RS08960	COG2197	response regulator
ACR54_RS08970	COG0066	3-isopropylmalate dehydratase activity
ACR54_RS08975	COG0473	3-isopropylmalate dehydrogenase activity
ACR54_RS08980	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ACR54_RS08990	COG0101	tRNA pseudouridine synthase activity
ACR54_RS08995	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
ACR54_RS09000	COG0135	phosphoribosylanthranilate isomerase activity
ACR54_RS09010	COG0582	viral genome integration into host DNA
ACR54_RS09055	COG0419	ATPase involved in DNA repair
ACR54_RS09175	COG5410	chromosome segregation
ACR54_RS09310	COG1598	PFAM Uncharacterised protein family UPF0150
ACR54_RS09330	COG0840	transmembrane signaling receptor activity
ACR54_RS09335	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
ACR54_RS09355	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ACR54_RS09360	COG2197	response regulator
ACR54_RS09365	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ACR54_RS09370	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ACR54_RS09385	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ACR54_RS09390	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ACR54_RS09395	COG1914	H( )-stimulated, divalent metal cation uptake system
ACR54_RS09400	COG1764	response to oxidative stress
ACR54_RS09405	COG2423	ornithine cyclodeaminase activity
ACR54_RS09415	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ACR54_RS09420	COG0765	amino acid transport
ACR54_RS09425	COG0765	amino acid transport
ACR54_RS09430	COG1126	abc transporter atp-binding protein
ACR54_RS09435	COG1902	pentaerythritol trinitrate reductase activity
ACR54_RS09440	COG0756	dUTP diphosphatase activity
ACR54_RS09450	COG0586	Pfam SNARE associated Golgi protein
ACR54_RS09465	COG1522	sequence-specific DNA binding
ACR54_RS09475	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ACR54_RS09480	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ACR54_RS09485	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ACR54_RS09490	COG0196	riboflavin kinase activity
ACR54_RS09495	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ACR54_RS09500	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ACR54_RS09500	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ACR54_RS09515	COG0210	DNA helicase
ACR54_RS09520	COG0488	(ABC) transporter
ACR54_RS09525	COG2890	protein-(glutamine-N5) methyltransferase activity
ACR54_RS09530	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ACR54_RS09535	COG2171	N-acyltransferase activity
ACR54_RS09560	COG3468	outer membrane autotransporter barrel domain protein
ACR54_RS09585	COG1278	Cold shock
ACR54_RS09595	COG1278	Cold shock
ACR54_RS09605	COG0544	peptidyl-prolyl cis-trans isomerase activity
ACR54_RS09610	COG0740	serine-type endopeptidase activity
ACR54_RS09615	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ACR54_RS09620	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ACR54_RS09625	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ACR54_RS09635	COG0556	nucleotide-excision repair
ACR54_RS09640	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ACR54_RS09650	COG1104	cysteine desulfurase activity
ACR54_RS09655	COG0822	iron-sulfur transferase activity
ACR54_RS09660	COG0316	Belongs to the HesB IscA family
ACR54_RS09665	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
ACR54_RS09670	COG0443	Heat shock 70 kDa protein
ACR54_RS09675	COG0633	Ferredoxin
ACR54_RS09680	COG2975	iron-sulfur cluster assembly
ACR54_RS09690	COG1803	Methylglyoxal synthase
ACR54_RS09695	COG1024	Enoyl-CoA hydratase
ACR54_RS09730	COG1309	transcriptional regulator
ACR54_RS09740	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ACR54_RS09745	COG1028	Short-chain dehydrogenase reductase Sdr
ACR54_RS09750	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
ACR54_RS09755	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ACR54_RS09770	COG1136	(ABC) transporter
ACR54_RS09775	COG0084	hydrolase, TatD family'
ACR54_RS09780	COG2501	S4 domain
ACR54_RS09805	COG0613	PHP domain protein
ACR54_RS09815	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ACR54_RS09820	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
ACR54_RS09820	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
ACR54_RS09825	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
ACR54_RS09830	COG0047	phosphoribosylformylglycinamidine synthase activity
ACR54_RS09830	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ACR54_RS09870	COG0747	negative chemotaxis
ACR54_RS09875	COG4608	Belongs to the ABC transporter superfamily
ACR54_RS09880	COG0444	Belongs to the ABC transporter superfamily
ACR54_RS09890	COG0601	transmembrane transport
ACR54_RS09895	COG2072	flavoprotein involved in K transport
ACR54_RS09910	COG1695	Transcriptional regulator
ACR54_RS09925	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ACR54_RS09925	COG0519	Catalyzes the synthesis of GMP from XMP
ACR54_RS09930	COG0582	viral genome integration into host DNA
ACR54_RS09985	COG3181	Tripartite tricarboxylate transporter family receptor
ACR54_RS09990	COG0384	phenazine biosynthesis protein PhzF
ACR54_RS10030	COG0411	ABC transporter
ACR54_RS10040	COG1012	belongs to the aldehyde dehydrogenase family
ACR54_RS10050	COG1349	DNA-binding transcription factor activity
ACR54_RS10060	COG1028	Short-chain dehydrogenase reductase Sdr
ACR54_RS10065	COG0583	DNA-binding transcription factor activity
ACR54_RS10070	COG2814	Major facilitator Superfamily
ACR54_RS10075	COG4774	siderophore transport
ACR54_RS10080	COG3712	iron ion homeostasis
ACR54_RS10085	COG1595	DNA-templated transcription, initiation
ACR54_RS10090	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ACR54_RS10100	COG4585	Histidine kinase
ACR54_RS10135	COG0653	protein targeting
ACR54_RS10150	COG1309	transcriptional regulator
ACR54_RS10165	COG1024	Enoyl-CoA hydratase
ACR54_RS10170	COG1960	acyl-CoA dehydrogenase activity
ACR54_RS10185	COG2207	Transcriptional regulator
ACR54_RS10190	COG2807	transmembrane transport
ACR54_RS10205	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ACR54_RS10210	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ACR54_RS10215	COG0656	L-ascorbic acid biosynthetic process
ACR54_RS10220	COG2814	Major facilitator Superfamily
ACR54_RS10225	COG0583	DNA-binding transcription factor activity
ACR54_RS10235	COG0183	Belongs to the thiolase family
ACR54_RS10255	COG1396	sequence-specific DNA binding
ACR54_RS10270	COG2814	Major facilitator Superfamily
ACR54_RS10280	COG1522	sequence-specific DNA binding
ACR54_RS10295	COG0583	DNA-binding transcription factor activity
ACR54_RS10320	COG3181	Tripartite tricarboxylate transporter family receptor
ACR54_RS10345	COG2764	glyoxalase bleomycin resistance protein dioxygenase
ACR54_RS10365	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ACR54_RS10370	COG1280	lysine exporter protein (LysE YggA)
ACR54_RS10375	COG1280	lysine exporter protein (LysE YggA)
ACR54_RS10385	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
ACR54_RS10425	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
ACR54_RS10430	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ACR54_RS10435	COG0390	transport system, permease component
ACR54_RS10445	COG0587	DNA-directed DNA polymerase activity
ACR54_RS10460	COG0840	transmembrane signaling receptor activity
ACR54_RS10465	COG0400	carboxylic ester hydrolase activity
ACR54_RS10475	COG1566	PFAM secretion protein HlyD family protein
ACR54_RS10485	COG1289	transmembrane transporter activity
ACR54_RS10495	COG0720	synthase
ACR54_RS10500	COG0602	queuosine metabolic process
ACR54_RS10505	COG1414	Transcriptional regulator
ACR54_RS10515	COG1012	belongs to the aldehyde dehydrogenase family
ACR54_RS10520	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ACR54_RS10525	COG0235	Class ii aldolase
ACR54_RS10560	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ACR54_RS10570	COG0842	Transport permease protein
ACR54_RS10575	COG1131	(ABC) transporter
ACR54_RS10590	COG2130	NADP-dependent
ACR54_RS10615	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ACR54_RS10630	COG1522	sequence-specific DNA binding
ACR54_RS10635	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ACR54_RS10640	COG0420	3'-5' exonuclease activity
ACR54_RS10650	COG3181	Tripartite tricarboxylate transporter family receptor
ACR54_RS10655	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ACR54_RS10655	COG2111	Na H antiporter
ACR54_RS10660	COG1006	Multisubunit Na H antiporter MnhC subunit
ACR54_RS10665	COG0651	ATP synthesis coupled electron transport
ACR54_RS10675	COG2212	antiporter activity
ACR54_RS10680	COG1320	monovalent cation:proton antiporter activity
ACR54_RS10695	COG0590	tRNA wobble adenosine to inosine editing
ACR54_RS10700	COG1619	proteins homologs of microcin C7 resistance protein MccF
ACR54_RS10705	COG0488	(ABC) transporter
ACR54_RS10710	COG0655	NAD(P)H dehydrogenase (quinone) activity
ACR54_RS10715	COG0583	DNA-binding transcription factor activity
ACR54_RS10745	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ACR54_RS10750	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACR54_RS10755	COG2252	PERMEase
ACR54_RS10760	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ACR54_RS10765	COG0583	DNA-binding transcription factor activity
ACR54_RS10770	COG3618	amidohydrolase
ACR54_RS10790	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
ACR54_RS10800	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
ACR54_RS10825	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ACR54_RS10830	COG0789	Transcriptional regulator
ACR54_RS10845	COG0678	peroxiredoxin activity
ACR54_RS10845	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ACR54_RS10855	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
ACR54_RS10860	COG0584	glycerophosphoryl diester phosphodiesterase
ACR54_RS10865	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ACR54_RS10875	COG4181	ATPase activity
ACR54_RS10885	COG3064	Membrane
ACR54_RS10885	COG3064	Membrane
ACR54_RS10885	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
ACR54_RS10885	COG3210	domain, Protein
ACR54_RS10885	COG3210	domain, Protein
ACR54_RS10885	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
ACR54_RS10895	COG3121	Chaperone
ACR54_RS10900	COG3188	usher protein
ACR54_RS10910	COG2831	hemolysin activation secretion protein
ACR54_RS10925	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ACR54_RS10950	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ACR54_RS10955	COG0765	amino acid transport
ACR54_RS10960	COG1126	abc transporter atp-binding protein
ACR54_RS10965	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ACR54_RS10970	COG1758	RNA polymerase activity
ACR54_RS10975	COG0194	GDP metabolic process
ACR54_RS10980	COG1028	Short-chain dehydrogenase reductase Sdr
ACR54_RS10985	COG0791	NLP P60 protein
ACR54_RS10990	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ACR54_RS11005	COG1561	YicC-like family, N-terminal region
ACR54_RS11010	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ACR54_RS11020	COG2079	MmgE PrpD family protein
ACR54_RS11025	COG1960	acyl-CoA dehydrogenase activity
ACR54_RS11035	COG0840	transmembrane signaling receptor activity
ACR54_RS11040	COG5001	Diguanylate cyclase
ACR54_RS11040	COG3300	MHYT domain
ACR54_RS11045	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ACR54_RS11050	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ACR54_RS11055	COG0174	glutamine synthetase
ACR54_RS11060	COG3852	Histidine kinase
ACR54_RS11090	COG0583	DNA-binding transcription factor activity
ACR54_RS11095	COG1741	Belongs to the pirin family
ACR54_RS11100	COG1741	Belongs to the pirin family
ACR54_RS11105	COG3842	ATPase activity
ACR54_RS11115	COG1840	ABC-type Fe3 transport system, periplasmic component
ACR54_RS11135	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ACR54_RS11140	COG0583	DNA-binding transcription factor activity
ACR54_RS11185	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ACR54_RS11200	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
ACR54_RS11210	COG0783	Belongs to the Dps family
ACR54_RS11250	COG0438	transferase activity, transferring glycosyl groups
ACR54_RS11265	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
ACR54_RS11280	COG3842	ATPase activity
ACR54_RS11285	COG0395	ABC-type sugar transport system, permease component
ACR54_RS11290	COG1175	transmembrane transport
ACR54_RS11305	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
ACR54_RS11315	COG0559	Belongs to the binding-protein-dependent transport system permease family
ACR54_RS11335	COG1794	racemase activity, acting on amino acids and derivatives
ACR54_RS11345	COG0625	glutathione transferase activity
ACR54_RS11350	COG2133	pyrroloquinoline quinone binding
ACR54_RS11360	COG0697	spore germination
ACR54_RS11365	COG2363	Small membrane protein
ACR54_RS11385	COG1464	Belongs to the NlpA lipoprotein family
ACR54_RS11395	COG0688	phosphatidylethanolamine metabolic process
ACR54_RS11405	COG1012	belongs to the aldehyde dehydrogenase family
ACR54_RS11415	COG0028	Belongs to the TPP enzyme family
ACR54_RS11425	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
ACR54_RS11425	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
ACR54_RS11435	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ACR54_RS11440	COG2186	Transcriptional regulator
ACR54_RS11445	COG3189	MarR family transcriptional regulator
ACR54_RS11450	COG2985	domain, Protein
ACR54_RS11455	COG0076	glutamate decarboxylase activity
ACR54_RS11460	COG2814	Major facilitator Superfamily
ACR54_RS11465	COG2205	protein histidine kinase activity
ACR54_RS11465	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ACR54_RS11470	COG2197	response regulator
ACR54_RS11475	COG4251	negative regulation of phosphorylation
ACR54_RS11475	COG3706	GGDEF domain
ACR54_RS11475	COG5001	Diguanylate cyclase
ACR54_RS11475	COG2203	Gaf domain
ACR54_RS11485	COG1253	flavin adenine dinucleotide binding
ACR54_RS11500	COG1595	DNA-templated transcription, initiation
ACR54_RS11510	COG2200	EAL domain
ACR54_RS11530	COG0410	ABC transporter
ACR54_RS11555	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ACR54_RS11560	COG0765	amino acid transport
ACR54_RS11565	COG1126	abc transporter atp-binding protein
ACR54_RS11595	COG1619	proteins homologs of microcin C7 resistance protein MccF
ACR54_RS11605	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ACR54_RS11620	COG2819	hydrolase of the alpha beta superfamily
ACR54_RS11645	COG0683	leucine binding
ACR54_RS11660	COG0431	NADPH-dependent FMN reductase
ACR54_RS11670	COG1024	Enoyl-CoA hydratase
ACR54_RS11680	COG2267	carboxylic ester hydrolase activity
ACR54_RS11690	COG0318	PFAM AMP-dependent synthetase and ligase
ACR54_RS11720	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ACR54_RS11730	COG2271	Major facilitator Superfamily
ACR54_RS11735	COG0154	amidase activity
ACR54_RS11750	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ACR54_RS11755	COG0318	PFAM AMP-dependent synthetase and ligase
ACR54_RS11760	COG1960	acyl-CoA dehydrogenase activity
ACR54_RS11765	COG0183	Belongs to the thiolase family
ACR54_RS11770	COG1250	3-hydroxyacyl-CoA dehydrogenase
ACR54_RS11770	COG1024	Enoyl-CoA hydratase
ACR54_RS11780	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ACR54_RS11790	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ACR54_RS11795	COG3181	Tripartite tricarboxylate transporter family receptor
ACR54_RS11800	COG1024	Enoyl-CoA hydratase
ACR54_RS11815	COG1454	alcohol dehydrogenase
ACR54_RS11820	COG2175	clavaminate synthase activity
ACR54_RS11845	COG1063	alcohol dehydrogenase
ACR54_RS11850	COG4172	Belongs to the ABC transporter superfamily
ACR54_RS11855	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ACR54_RS11860	COG0601	transmembrane transport
ACR54_RS11865	COG0747	negative chemotaxis
ACR54_RS11870	COG0402	S-adenosylhomocysteine deaminase activity
ACR54_RS11910	COG1129	ABC transporter
ACR54_RS11915	COG1172	Belongs to the binding-protein-dependent transport system permease family
ACR54_RS11940	COG1137	ATPase activity
ACR54_RS11960	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ACR54_RS11965	COG0477	Major facilitator Superfamily
ACR54_RS11970	COG0583	DNA-binding transcription factor activity
ACR54_RS11975	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
ACR54_RS11985	COG1028	Short-chain dehydrogenase reductase Sdr
ACR54_RS12000	COG0477	Major facilitator Superfamily
ACR54_RS12005	COG0129	dihydroxy-acid dehydratase activity
ACR54_RS12010	COG2186	Transcriptional regulator
ACR54_RS12015	COG0583	DNA-binding transcription factor activity
ACR54_RS12035	COG1028	Short-chain dehydrogenase reductase Sdr
ACR54_RS12045	COG1177	transmembrane transport
ACR54_RS12050	COG3842	ATPase activity
ACR54_RS12060	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ACR54_RS12080	COG1126	abc transporter atp-binding protein
ACR54_RS12095	COG0583	DNA-binding transcription factor activity
ACR54_RS12120	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ACR54_RS12140	COG3665	Urea carboxylase-associated protein
ACR54_RS12155	COG0765	amino acid transport
ACR54_RS12160	COG0765	amino acid transport
ACR54_RS12165	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ACR54_RS12175	COG2182	Extracellular solute-binding protein
ACR54_RS12180	COG1175	transmembrane transport
ACR54_RS12185	COG3833	ABC-type maltose transport systems, permease component
ACR54_RS12195	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ACR54_RS12200	COG3842	ATPase activity
ACR54_RS12205	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ACR54_RS12210	COG4948	Mandelate Racemase Muconate Lactonizing
ACR54_RS12215	COG3181	Tripartite tricarboxylate transporter family receptor
ACR54_RS12220	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ACR54_RS12225	COG0066	3-isopropylmalate dehydratase activity
ACR54_RS12280	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ACR54_RS12310	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ACR54_RS12345	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ACR54_RS12350	COG0456	acetyltransferase
ACR54_RS12365	COG2900	Belongs to the SlyX family
ACR54_RS12370	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ACR54_RS12385	COG1122	ATPase activity
ACR54_RS12430	COG1960	acyl-CoA dehydrogenase activity
ACR54_RS12435	COG1960	acyl-CoA dehydrogenase activity
ACR54_RS12450	COG1024	Enoyl-CoA hydratase
ACR54_RS12465	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ACR54_RS12480	COG0519	Catalyzes the synthesis of GMP from XMP
ACR54_RS12480	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ACR54_RS12500	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ACR54_RS12510	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ACR54_RS12515	COG3181	Tripartite tricarboxylate transporter family receptor
ACR54_RS12520	COG0583	DNA-binding transcription factor activity
ACR54_RS12525	COG0477	Major facilitator Superfamily
ACR54_RS12530	COG0028	Belongs to the TPP enzyme family
ACR54_RS12535	COG0583	DNA-binding transcription factor activity
ACR54_RS12585	COG1802	Transcriptional regulator
ACR54_RS12595	COG3959	Transketolase, thiamine diphosphate binding domain
ACR54_RS12600	COG3958	Transketolase
ACR54_RS12630	COG3258	Cytochrome c
ACR54_RS12635	COG3042	response to heat
ACR54_RS12645	COG2733	membrane
ACR54_RS12670	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
ACR54_RS12690	COG3243	poly(R)-hydroxyalkanoic acid synthase
ACR54_RS12700	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ACR54_RS12705	COG1129	ABC transporter
ACR54_RS12705	COG0842	Transport permease protein
ACR54_RS12710	COG0842	Transport permease protein
ACR54_RS12720	COG1028	Short-chain dehydrogenase reductase Sdr
ACR54_RS12740	COG2259	Doxx family
ACR54_RS12745	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ACR54_RS12790	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ACR54_RS12815	COG0386	Belongs to the glutathione peroxidase family
ACR54_RS12840	COG0095	Lipoate-protein ligase
ACR54_RS12850	COG0740	serine-type endopeptidase activity
ACR54_RS12860	COG0640	Transcriptional regulator
ACR54_RS12865	COG2059	Chromate
ACR54_RS12875	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ACR54_RS12880	COG4221	oxidoreductase activity
ACR54_RS12900	COG0010	Belongs to the arginase family
ACR54_RS12905	COG1126	abc transporter atp-binding protein
ACR54_RS12910	COG0765	amino acid transport
ACR54_RS12915	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ACR54_RS12930	COG0084	hydrolase, TatD family'
ACR54_RS12940	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ACR54_RS12945	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ACR54_RS12965	COG1024	Enoyl-CoA hydratase
ACR54_RS12965	COG1250	3-hydroxyacyl-CoA dehydrogenase
ACR54_RS12970	COG1960	acyl-CoA dehydrogenase activity
ACR54_RS12975	COG2914	Belongs to the UPF0125 (RnfH) family
ACR54_RS12985	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ACR54_RS13010	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
ACR54_RS13020	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ACR54_RS13025	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ACR54_RS13030	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ACR54_RS13040	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ACR54_RS13045	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ACR54_RS13055	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ACR54_RS13060	COG0750	zinc metalloprotease
ACR54_RS13065	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
ACR54_RS13070	COG0575	Belongs to the CDS family
ACR54_RS13075	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ACR54_RS13080	COG0233	cytoplasmic translational termination
ACR54_RS13085	COG0528	UMP kinase activity
ACR54_RS13090	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ACR54_RS13095	COG0052	Belongs to the universal ribosomal protein uS2 family
ACR54_RS13100	COG0024	Methionine aminopeptidase
ACR54_RS13105	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
ACR54_RS13125	COG1286	toxin biosynthetic process
ACR54_RS13135	COG0285	dihydrofolate synthase activity
ACR54_RS13145	COG3181	Tripartite tricarboxylate transporter family receptor
ACR54_RS13150	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ACR54_RS13170	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
ACR54_RS13190	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ACR54_RS13200	COG1677	Flagellar hook-basal body complex protein FliE
ACR54_RS13205	COG1766	The M ring may be actively involved in energy transduction
ACR54_RS13210	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ACR54_RS13215	COG1317	bacterial-type flagellum organization
ACR54_RS13225	COG2882	bacterial-type flagellum organization
ACR54_RS13235	COG1580	Controls the rotational direction of flagella during chemotaxis
ACR54_RS13245	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ACR54_RS13270	COG0840	transmembrane signaling receptor activity
ACR54_RS13275	COG0840	transmembrane signaling receptor activity
ACR54_RS13285	COG0840	transmembrane signaling receptor activity
ACR54_RS13290	COG0840	transmembrane signaling receptor activity
ACR54_RS13300	COG1256	bacterial-type flagellum assembly
ACR54_RS13310	COG1706	bacterial-type flagellum-dependent cell motility
ACR54_RS13330	COG1749	Flagellar hook protein flgE
ACR54_RS13355	COG2747	anti-sigma28 factor FlgM
ACR54_RS13380	COG0840	transmembrane signaling receptor activity
ACR54_RS13385	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
ACR54_RS13390	COG0745	RESPONSE REGULATOR receiver
ACR54_RS13395	COG2201	protein-glutamate methylesterase activity
ACR54_RS13400	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ACR54_RS13405	COG0840	transmembrane signaling receptor activity
ACR54_RS13420	COG0745	RESPONSE REGULATOR receiver
ACR54_RS13460	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ACR54_RS13465	COG0508	dehydrogenase complex catalyzes the overall conversion of
ACR54_RS13470	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
ACR54_RS13480	COG4566	intracellular signal transduction
ACR54_RS13485	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ACR54_RS13490	COG0339	signal peptide processing
ACR54_RS13500	COG1999	signal sequence binding
ACR54_RS13525	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ACR54_RS13535	COG1187	pseudouridine synthase activity
ACR54_RS13540	COG3161	chorismate lyase activity
ACR54_RS13550	COG1280	lysine exporter protein (LysE YggA)
ACR54_RS13560	COG4172	Belongs to the ABC transporter superfamily
ACR54_RS13565	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ACR54_RS13570	COG0601	transmembrane transport
ACR54_RS13575	COG0747	negative chemotaxis
ACR54_RS13585	COG0583	DNA-binding transcription factor activity
ACR54_RS13600	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ACR54_RS13600	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ACR54_RS13605	COG0668	transmembrane transport
ACR54_RS13610	COG0165	Argininosuccinate lyase
ACR54_RS13615	COG0778	Nitroreductase
ACR54_RS13620	COG0789	Transcriptional regulator
ACR54_RS13630	COG0501	Belongs to the peptidase M48B family
ACR54_RS13640	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ACR54_RS13670	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ACR54_RS13675	COG0154	amidase activity
ACR54_RS13720	COG3181	Tripartite tricarboxylate transporter family receptor
ACR54_RS13725	COG0129	dihydroxy-acid dehydratase activity
ACR54_RS13735	COG0583	DNA-binding transcription factor activity
ACR54_RS13740	COG1250	3-hydroxyacyl-CoA dehydrogenase
ACR54_RS13745	COG3246	L-lysine catabolic process to acetate
ACR54_RS13750	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ACR54_RS13770	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ACR54_RS13795	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
ACR54_RS13810	COG0667	Aldo Keto reductase
ACR54_RS13815	COG0656	L-ascorbic acid biosynthetic process
ACR54_RS13820	COG5265	(ABC) transporter
ACR54_RS13870	COG1522	sequence-specific DNA binding
ACR54_RS13895	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ACR54_RS13920	COG0776	regulation of translation
ACR54_RS13925	COG0072	phenylalanine-tRNA ligase activity
ACR54_RS13925	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ACR54_RS13930	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ACR54_RS13935	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ACR54_RS13940	COG0291	Belongs to the bacterial ribosomal protein bL35 family
ACR54_RS13955	COG0347	Belongs to the P(II) protein family
ACR54_RS13960	COG0004	ammonium transporteR
ACR54_RS13970	COG2271	Major facilitator Superfamily
ACR54_RS14000	COG0506	proline dehydrogenase activity
ACR54_RS14000	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
ACR54_RS14000	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
ACR54_RS14010	COG3008	intermembrane lipid transfer
ACR54_RS14015	COG2995	paraquat-inducible protein a
ACR54_RS14020	COG0542	response to heat
ACR54_RS14025	COG4953	penicillin-binding protein 1C
ACR54_RS14035	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
ACR54_RS14040	COG1278	Cold shock
ACR54_RS14050	COG0183	Belongs to the thiolase family
ACR54_RS14055	COG0038	chloride channel
ACR54_RS14060	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ACR54_RS14065	COG1570	exodeoxyribonuclease VII activity
ACR54_RS14070	COG0811	peptide transport
ACR54_RS14080	COG1663	tetraacyldisaccharide 4'-kinase activity
ACR54_RS14085	COG2835	tetraacyldisaccharide 4'-kinase activity
ACR54_RS14090	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
ACR54_RS14095	COG0563	adenylate kinase activity
ACR54_RS14105	COG0728	peptidoglycan biosynthetic process
ACR54_RS14130	COG0268	Binds directly to 16S ribosomal RNA
ACR54_RS14135	COG3836	Belongs to the HpcH HpaI aldolase family
ACR54_RS14155	COG2186	Transcriptional regulator
ACR54_RS14170	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ACR54_RS14180	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ACR54_RS14185	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ACR54_RS14190	COG0137	argininosuccinate synthase activity
ACR54_RS14200	COG3158	transport of potassium into the cell
ACR54_RS14205	COG0642	Histidine kinase
ACR54_RS14235	COG0776	regulation of translation
ACR54_RS14245	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ACR54_RS14250	COG0557	exoribonuclease II activity
ACR54_RS14275	COG0679	Auxin Efflux Carrier
ACR54_RS14280	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ACR54_RS14285	COG2391	methyltransferase activity
ACR54_RS14290	COG0069	glutamate synthase activity
ACR54_RS14295	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ACR54_RS14305	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
ACR54_RS14310	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ACR54_RS14335	COG3706	GGDEF domain
ACR54_RS14345	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ACR54_RS14375	COG3909	cytochrome
ACR54_RS14385	COG0625	glutathione transferase activity
ACR54_RS14390	COG0730	response to heat
ACR54_RS14395	COG0482	sulfurtransferase activity
ACR54_RS14400	COG0583	DNA-binding transcription factor activity
ACR54_RS14405	COG3181	Tripartite tricarboxylate transporter family receptor
ACR54_RS14430	COG0247	lactate metabolic process
ACR54_RS14435	COG0277	FAD linked oxidase domain protein
ACR54_RS14440	COG0277	FAD linked oxidase domain protein
ACR54_RS14445	COG0277	FAD linked oxidase domain protein
ACR54_RS14450	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ACR54_RS14455	COG0312	modulator of DNA gyrase
ACR54_RS14470	COG0308	aminopeptidase N
ACR54_RS14475	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
ACR54_RS14495	COG0436	Aminotransferase
ACR54_RS14500	COG3737	Protein of unknown function (DUF498/DUF598)
ACR54_RS14505	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ACR54_RS14510	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
ACR54_RS14515	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
ACR54_RS14525	COG0305	Participates in initiation and elongation during chromosome replication
ACR54_RS14535	COG0359	binds to the 23S rRNA
ACR54_RS14540	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ACR54_RS14545	COG2965	DNA replication, synthesis of RNA primer
ACR54_RS14550	COG0360	Binds together with S18 to 16S ribosomal RNA
ACR54_RS14555	COG1469	GTP cyclohydrolase I activity
ACR54_RS14560	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ACR54_RS14565	COG0142	geranyltranstransferase activity
ACR54_RS14570	COG1722	exodeoxyribonuclease VII activity
ACR54_RS14610	COG0501	Belongs to the peptidase M48B family
ACR54_RS14630	COG1846	Transcriptional regulator
ACR54_RS14640	COG1566	PFAM secretion protein HlyD family protein
ACR54_RS14645	COG2814	Major facilitator Superfamily
ACR54_RS14650	COG0473	3-isopropylmalate dehydrogenase activity
ACR54_RS14660	COG0747	negative chemotaxis
ACR54_RS14665	COG0601	transmembrane transport
ACR54_RS14670	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ACR54_RS14675	COG4172	Belongs to the ABC transporter superfamily
ACR54_RS14680	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ACR54_RS14705	COG1012	belongs to the aldehyde dehydrogenase family
ACR54_RS14710	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ACR54_RS14715	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ACR54_RS14725	COG0433	COG0433 Predicted ATPase
ACR54_RS14730	COG0217	transcriptional regulatory protein
ACR54_RS14735	COG0151	Belongs to the GarS family
ACR54_RS14745	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ACR54_RS14750	COG0799	negative regulation of ribosome biogenesis
ACR54_RS14755	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ACR54_RS14760	COG0424	maF-like protein
ACR54_RS14765	COG1301	dicarboxylic acid transport
ACR54_RS14770	COG4191	Histidine kinase
ACR54_RS14775	COG2204	response regulator
ACR54_RS14800	COG1418	mRNA catabolic process
ACR54_RS14805	COG0500	methyltransferase
ACR54_RS14810	COG0477	Major facilitator Superfamily
ACR54_RS14820	COG0583	DNA-binding transcription factor activity
ACR54_RS14850	COG1530	ribonuclease E activity
ACR54_RS14860	COG1132	(ABC) transporter
ACR54_RS14900	COG0726	polysaccharide deacetylase
ACR54_RS14905	COG0438	transferase activity, transferring glycosyl groups
ACR54_RS14920	COG1643	Atp-dependent helicase
ACR54_RS14925	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ACR54_RS14925	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
ACR54_RS14930	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
ACR54_RS14935	COG0704	Plays a role in the regulation of phosphate uptake
ACR54_RS14940	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
ACR54_RS14945	COG1960	acyl-CoA dehydrogenase activity
ACR54_RS14950	COG1322	Protein conserved in bacteria
ACR54_RS14960	COG2094	Belongs to the DNA glycosylase MPG family
ACR54_RS14965	COG1393	Belongs to the ArsC family
ACR54_RS14970	COG1177	transmembrane transport
ACR54_RS14975	COG1176	ABC-type spermidine putrescine transport system, permease component I
ACR54_RS14980	COG3842	ATPase activity
ACR54_RS14990	COG3642	lipopolysaccharide core region biosynthetic process
ACR54_RS15000	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
ACR54_RS15005	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ACR54_RS15015	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
ACR54_RS15015	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
ACR54_RS15020	COG1802	Transcriptional regulator
ACR54_RS15035	COG3437	response regulator, receiver
ACR54_RS15040	COG0784	Response regulator, receiver
ACR54_RS15040	COG5002	protein histidine kinase activity
ACR54_RS15040	COG2198	Histidine kinase
ACR54_RS15065	COG1126	abc transporter atp-binding protein
ACR54_RS15085	COG2050	protein possibly involved in aromatic compounds catabolism
ACR54_RS15090	COG1024	Enoyl-CoA hydratase
ACR54_RS15095	COG1012	belongs to the aldehyde dehydrogenase family
ACR54_RS15100	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ACR54_RS15105	COG2151	metal-sulfur cluster biosynthetic enzyme
ACR54_RS15110	COG3396	Phenylacetate-CoA oxygenase
ACR54_RS15115	COG3460	Phenylacetate-CoA oxygenase
ACR54_RS15120	COG3396	Phenylacetate-CoA oxygenase
ACR54_RS15135	COG0583	DNA-binding transcription factor activity
ACR54_RS15145	COG1335	isochorismatase
ACR54_RS15150	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
ACR54_RS15155	COG0501	Belongs to the peptidase M48B family
ACR54_RS15160	COG1162	GTPase activity
ACR54_RS15165	COG3622	Belongs to the hyi family
ACR54_RS15170	COG0494	nUDIX hydrolase
ACR54_RS15175	COG0335	large ribosomal subunit rRNA binding
ACR54_RS15195	COG2895	sulfate adenylyltransferase (ATP) activity
ACR54_RS15205	COG0175	sulfate reduction
ACR54_RS15210	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
ACR54_RS15215	COG4208	sulfate ABC transporter
ACR54_RS15220	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
ACR54_RS15225	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
ACR54_RS15230	COG0450	alkyl hydroperoxide reductase
ACR54_RS15235	COG1960	acyl-CoA dehydrogenase activity
ACR54_RS15240	COG2985	domain, Protein
ACR54_RS15255	COG0123	including yeast histone deacetylase and acetoin utilization protein
ACR54_RS15260	COG2951	lytic endotransglycosylase activity
ACR54_RS15270	COG0587	DNA-directed DNA polymerase activity
ACR54_RS15275	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ACR54_RS15280	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
ACR54_RS15285	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
ACR54_RS15305	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ACR54_RS15310	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ACR54_RS15315	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ACR54_RS15320	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ACR54_RS15325	COG0077	Prephenate dehydratase
ACR54_RS15325	COG1605	Chorismate mutase
ACR54_RS15330	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
ACR54_RS15345	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ACR54_RS15360	COG0582	viral genome integration into host DNA
ACR54_RS15375	COG3311	Transcriptional regulator
ACR54_RS15490	COG1061	Type III restriction enzyme res subunit
ACR54_RS15580	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ACR54_RS15595	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
ACR54_RS15775	COG3706	GGDEF domain
ACR54_RS15785	COG0589	response to stress
ACR54_RS15795	COG2951	lytic endotransglycosylase activity
ACR54_RS15800	COG2833	Protein of unknown function (DUF455)
ACR54_RS15805	COG0297	glycogen (starch) synthase activity
ACR54_RS15815	COG1132	(ABC) transporter
ACR54_RS15820	COG0189	ligase activity
ACR54_RS15820	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ACR54_RS15825	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ACR54_RS15825	COG0189	ligase activity
ACR54_RS15830	COG3038	cytochrome b561
ACR54_RS15835	COG3237	CsbD-like
ACR54_RS15845	COG2823	Periplasmic or secreted lipoprotein
ACR54_RS15860	COG0672	)-iron permease
ACR54_RS15875	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
ACR54_RS15880	COG1028	Short-chain dehydrogenase reductase Sdr
ACR54_RS15885	COG3243	poly(R)-hydroxyalkanoic acid synthase
ACR54_RS15895	COG0564	pseudouridine synthase activity
ACR54_RS15935	COG1199	ATP-dependent helicase activity
ACR54_RS15940	COG2183	response to ionizing radiation
ACR54_RS15965	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
ACR54_RS15970	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ACR54_RS15975	COG0508	dehydrogenase complex catalyzes the overall conversion of
ACR54_RS15980	COG0567	Dehydrogenase, E1 component
ACR54_RS15985	COG1297	OPT oligopeptide transporter protein
ACR54_RS15995	COG0281	malic enzyme
ACR54_RS15995	COG0280	phosphate acetyltransferase
ACR54_RS16000	COG4774	siderophore transport
ACR54_RS16005	COG3128	pkhd-type hydroxylase
ACR54_RS16030	COG1840	ABC-type Fe3 transport system, periplasmic component
ACR54_RS16035	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ACR54_RS16045	COG3842	ATPase activity
ACR54_RS16050	COG0583	DNA-binding transcription factor activity
ACR54_RS16055	COG0372	Belongs to the citrate synthase family
ACR54_RS16060	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
ACR54_RS16065	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ACR54_RS16070	COG1053	succinate dehydrogenase
ACR54_RS16075	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
ACR54_RS16080	COG2009	succinate dehydrogenase
ACR54_RS16085	COG2188	Transcriptional regulator
ACR54_RS16090	COG0039	L-malate dehydrogenase activity
ACR54_RS16110	COG1981	membrane
ACR54_RS16130	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ACR54_RS16135	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ACR54_RS16145	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
ACR54_RS16160	COG0148	phosphopyruvate hydratase activity
ACR54_RS16170	COG0504	CTP synthase activity
ACR54_RS16190	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ACR54_RS16195	COG0601	transmembrane transport
ACR54_RS16200	COG0747	negative chemotaxis
ACR54_RS16205	COG4172	Belongs to the ABC transporter superfamily
ACR54_RS16210	COG1446	asparaginase
ACR54_RS16245	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
ACR54_RS16250	COG0697	spore germination
ACR54_RS16255	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ACR54_RS16265	COG3193	protein, possibly involved in utilization of glycolate and propanediol
ACR54_RS16270	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ACR54_RS16275	COG0791	NLP P60 protein
ACR54_RS16285	COG0583	DNA-binding transcription factor activity
ACR54_RS16300	COG0583	DNA-binding transcription factor activity
ACR54_RS16310	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ACR54_RS16330	COG1381	Involved in DNA repair and RecF pathway recombination
ACR54_RS16335	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ACR54_RS16340	COG0571	ribonuclease III activity
ACR54_RS16345	COG0681	Belongs to the peptidase S26 family
ACR54_RS16350	COG0481	GTPase activity
ACR54_RS16355	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ACR54_RS16375	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ACR54_RS16380	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ACR54_RS16385	COG1028	Short-chain dehydrogenase reductase Sdr
ACR54_RS16395	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ACR54_RS16405	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ACR54_RS16410	COG1399	metal-binding, possibly nucleic acid-binding protein
ACR54_RS16415	COG0424	maF-like protein
ACR54_RS16425	COG3023	N-Acetylmuramoyl-L-alanine amidase
ACR54_RS16430	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
ACR54_RS16435	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ACR54_RS16440	COG0546	phosphoglycolate phosphatase activity
ACR54_RS16445	COG0564	pseudouridine synthase activity
ACR54_RS16450	COG1530	ribonuclease E activity
ACR54_RS16455	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
ACR54_RS16460	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
ACR54_RS16465	COG0159	tryptophan synthase activity
ACR54_RS16485	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ACR54_RS16490	COG3228	Belongs to the MtfA family
ACR54_RS16500	COG0251	oxidation-reduction process
ACR54_RS16525	COG2878	Part of a membrane complex involved in electron transport
ACR54_RS16530	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ACR54_RS16535	COG0411	ABC transporter
ACR54_RS16565	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ACR54_RS16595	COG1268	BioY protein
ACR54_RS16600	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
ACR54_RS16605	COG1122	ATPase activity
ACR54_RS16610	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ACR54_RS16615	COG2917	probably involved in intracellular septation
ACR54_RS16620	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ACR54_RS16625	COG0625	glutathione transferase activity
ACR54_RS16635	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ACR54_RS16640	COG0765	amino acid transport
ACR54_RS16650	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ACR54_RS16660	COG1196	nuclear chromosome segregation
ACR54_RS16665	COG0477	Major facilitator Superfamily
ACR54_RS16670	COG1573	uracil-dna glycosylase
ACR54_RS16675	COG1214	PFAM Peptidase M22, glycoprotease
ACR54_RS16690	COG0450	alkyl hydroperoxide reductase
ACR54_RS16695	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ACR54_RS16700	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ACR54_RS16705	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ACR54_RS16710	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ACR54_RS16715	COG0560	Phosphoserine phosphatase
ACR54_RS16725	COG1007	ATP synthesis coupled electron transport
ACR54_RS16740	COG0713	ATP synthesis coupled electron transport
ACR54_RS16750	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACR54_RS16755	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
ACR54_RS16760	COG1034	ATP synthesis coupled electron transport
ACR54_RS16770	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
ACR54_RS16775	COG0649	NAD binding
ACR54_RS16780	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACR54_RS16785	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACR54_RS16790	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ACR54_RS16795	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
ACR54_RS16815	COG0671	phosphoesterase, PA-phosphatase related
ACR54_RS16825	COG1803	Methylglyoxal synthase
ACR54_RS16825	COG1597	lipid kinase activity
ACR54_RS16835	COG2084	Dehydrogenase
ACR54_RS16850	COG0583	DNA-binding transcription factor activity
ACR54_RS16885	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
ACR54_RS16890	COG5001	Diguanylate cyclase
ACR54_RS16890	COG3706	GGDEF domain
ACR54_RS16890	COG2203	Gaf domain
ACR54_RS16890	COG4251	negative regulation of phosphorylation
ACR54_RS16895	COG2201	protein-glutamate methylesterase activity
ACR54_RS16920	COG0840	transmembrane signaling receptor activity
ACR54_RS16935	COG0330	HflC and HflK could
ACR54_RS16955	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ACR54_RS16955	COG0475	glutathione-regulated potassium exporter activity
ACR54_RS16965	COG2207	Transcriptional regulator
ACR54_RS17015	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ACR54_RS17025	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ACR54_RS17030	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
ACR54_RS17035	COG0330	HflC and HflK could
ACR54_RS17040	COG0330	HflC and HflK could
ACR54_RS17045	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ACR54_RS17050	COG1923	regulation of RNA biosynthetic process
ACR54_RS17055	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ACR54_RS17060	COG1160	GTP binding
ACR54_RS17065	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ACR54_RS17070	COG2976	Protein conserved in bacteria
ACR54_RS17075	COG0124	histidyl-tRNA synthetase
ACR54_RS17090	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ACR54_RS17095	COG0105	UTP biosynthetic process
ACR54_RS17100	COG0525	valine-tRNA ligase activity
ACR54_RS17110	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ACR54_RS17115	COG0228	four-way junction DNA binding
ACR54_RS17125	COG0425	Belongs to the sulfur carrier protein TusA family
ACR54_RS17130	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ACR54_RS17180	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ACR54_RS17185	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ACR54_RS17185	COG0543	2 iron, 2 sulfur cluster binding
ACR54_RS17190	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
ACR54_RS17195	COG2076	Multidrug Resistance protein
ACR54_RS17200	COG3217	Mosc domain protein beta barrel domain protein
ACR54_RS17200	COG0633	Ferredoxin
ACR54_RS17205	COG5285	phytanoyl-CoA dioxygenase
ACR54_RS17210	COG0662	Cupin 2, conserved barrel domain protein
ACR54_RS17220	COG0456	acetyltransferase
ACR54_RS17235	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ACR54_RS17240	COG2358	TRAP transporter, solute receptor (TAXI family
ACR54_RS17250	COG2311	Membrane
ACR54_RS17275	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ACR54_RS17285	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
ACR54_RS17290	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ACR54_RS17295	COG1760	l-serine dehydratase
ACR54_RS17300	COG1283	sodium-dependent phosphate transmembrane transporter activity
ACR54_RS17305	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ACR54_RS17310	COG0412	Dienelactone hydrolase
ACR54_RS17315	COG0428	transporter
ACR54_RS17320	COG0477	Major facilitator Superfamily
ACR54_RS17325	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ACR54_RS17330	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ACR54_RS17335	COG1845	cytochrome c oxidase, subunit III
ACR54_RS17340	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
ACR54_RS17350	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ACR54_RS17350	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ACR54_RS17370	COG0183	Belongs to the thiolase family
ACR54_RS17385	COG4176	ABC-type proline glycine betaine transport system permease component
ACR54_RS17395	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ACR54_RS17400	COG2814	Major facilitator Superfamily
ACR54_RS17405	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ACR54_RS17410	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ACR54_RS17430	COG1846	Transcriptional regulator
ACR54_RS17435	COG2814	Major facilitator Superfamily
ACR54_RS17440	COG0495	leucyl-tRNA aminoacylation
ACR54_RS17455	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ACR54_RS17470	COG0154	amidase activity
ACR54_RS17485	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ACR54_RS17535	COG0583	DNA-binding transcription factor activity
ACR54_RS17540	COG0427	acetyl-CoA hydrolase
ACR54_RS17545	COG0583	DNA-binding transcription factor activity
ACR54_RS17550	COG1511	domain protein
ACR54_RS17550	COG3264	Mechanosensitive ion channel
ACR54_RS17560	COG4221	oxidoreductase activity
ACR54_RS17585	COG2176	DNA-directed DNA polymerase activity
ACR54_RS17605	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ACR54_RS17610	COG3384	dioxygenase
ACR54_RS17625	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ACR54_RS17630	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
ACR54_RS17685	COG4964	Belongs to the GSP D family
ACR54_RS17715	COG5001	Diguanylate cyclase
ACR54_RS17715	COG3300	MHYT domain
ACR54_RS17730	COG1846	Transcriptional regulator
ACR54_RS17775	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
ACR54_RS17785	COG2070	2-Nitropropane dioxygenase
ACR54_RS17795	COG2610	gluconate transmembrane transporter activity
ACR54_RS17805	COG0456	acetyltransferase
ACR54_RS17815	COG1408	metallophosphoesterase
ACR54_RS17835	COG3128	pkhd-type hydroxylase
ACR54_RS17845	COG4774	siderophore transport
ACR54_RS17855	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ACR54_RS17900	COG0583	DNA-binding transcription factor activity
ACR54_RS17905	COG2814	Major facilitator Superfamily
ACR54_RS17915	COG0148	phosphopyruvate hydratase activity
ACR54_RS17925	COG1301	dicarboxylic acid transport
ACR54_RS17940	COG2159	amidohydrolase
ACR54_RS17950	COG0583	DNA-binding transcription factor activity
ACR54_RS17965	COG1024	Enoyl-CoA hydratase
ACR54_RS17970	COG2186	Transcriptional regulator
ACR54_RS17975	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ACR54_RS17980	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ACR54_RS17990	COG0235	Class ii aldolase
ACR54_RS18020	COG0833	amino acid
ACR54_RS18035	COG5265	(ABC) transporter
ACR54_RS18055	COG0840	transmembrane signaling receptor activity
ACR54_RS18070	COG1360	Flagellar Motor Protein
ACR54_RS18085	COG1971	Probably functions as a manganese efflux pump
ACR54_RS18090	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ACR54_RS18100	COG1959	2 iron, 2 sulfur cluster binding
ACR54_RS18110	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ACR54_RS18115	COG2814	Major facilitator Superfamily
ACR54_RS18125	COG3284	Transcriptional regulator
ACR54_RS18130	COG1012	belongs to the aldehyde dehydrogenase family
ACR54_RS18145	COG1028	Short-chain dehydrogenase reductase Sdr
ACR54_RS18150	COG2207	Transcriptional regulator
ACR54_RS18155	COG4608	Belongs to the ABC transporter superfamily
ACR54_RS18160	COG0444	Belongs to the ABC transporter superfamily
ACR54_RS18195	COG0583	DNA-binding transcription factor activity
ACR54_RS18200	COG0747	negative chemotaxis
ACR54_RS18210	COG0625	glutathione transferase activity
ACR54_RS18245	COG1595	DNA-templated transcription, initiation
ACR54_RS18250	COG3712	iron ion homeostasis
ACR54_RS18255	COG4774	siderophore transport
ACR54_RS18265	COG2814	Major facilitator Superfamily
ACR54_RS18270	COG2197	response regulator
ACR54_RS18285	COG0583	DNA-binding transcription factor activity
ACR54_RS18295	COG0154	amidase activity
ACR54_RS18305	COG4133	protoheme IX ABC transporter activity
ACR54_RS18340	COG1309	transcriptional regulator
ACR54_RS18365	COG0411	ABC transporter
ACR54_RS18370	COG1028	Short-chain dehydrogenase reductase Sdr
ACR54_RS18400	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ACR54_RS18410	COG0508	dehydrogenase complex catalyzes the overall conversion of
ACR54_RS18415	COG1024	Enoyl-CoA hydratase
ACR54_RS18420	COG0022	dehydrogenase e1 component
ACR54_RS18420	COG0508	dehydrogenase complex catalyzes the overall conversion of
ACR54_RS18425	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ACR54_RS18430	COG0402	S-adenosylhomocysteine deaminase activity
ACR54_RS18440	COG0179	Fumarylacetoacetate (FAA) hydrolase
ACR54_RS18445	COG2188	Transcriptional regulator
ACR54_RS18460	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ACR54_RS18465	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ACR54_RS18475	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ACR54_RS18480	COG3585	molybdate ion transport
ACR54_RS18525	COG0583	DNA-binding transcription factor activity
ACR54_RS18530	COG4948	Mandelate Racemase Muconate Lactonizing
ACR54_RS18535	COG3181	Tripartite tricarboxylate transporter family receptor
ACR54_RS18550	COG2814	Major facilitator Superfamily
ACR54_RS18565	COG3181	Tripartite tricarboxylate transporter family receptor
ACR54_RS18580	COG2301	Belongs to the HpcH HpaI aldolase family
ACR54_RS18585	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ACR54_RS18620	COG2863	cytochrome
ACR54_RS18625	COG3258	Cytochrome c
ACR54_RS18645	COG1538	Outer membrane efflux protein
ACR54_RS18650	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ACR54_RS18655	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ACR54_RS18665	COG3210	domain, Protein
ACR54_RS18670	COG2205	protein histidine kinase activity
ACR54_RS18680	COG0683	leucine binding
ACR54_RS18685	COG0559	Belongs to the binding-protein-dependent transport system permease family
ACR54_RS18715	COG2301	Belongs to the HpcH HpaI aldolase family
ACR54_RS18720	COG1960	acyl-CoA dehydrogenase activity
ACR54_RS18725	COG0427	acetyl-CoA hydrolase
ACR54_RS18750	COG0583	DNA-binding transcription factor activity
ACR54_RS18795	COG1028	Short-chain dehydrogenase reductase Sdr
ACR54_RS18815	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ACR54_RS18840	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ACR54_RS18865	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ACR54_RS18875	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ACR54_RS18880	COG1538	Outer membrane efflux protein
ACR54_RS18885	COG1136	(ABC) transporter
ACR54_RS18885	COG0577	efflux transmembrane transporter activity
ACR54_RS18890	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ACR54_RS18905	COG0259	pyridoxamine-phosphate oxidase activity
ACR54_RS18910	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ACR54_RS18915	COG0579	oxidoreductase
ACR54_RS18925	COG3210	domain, Protein
ACR54_RS18935	COG0405	Gamma-glutamyltransferase
ACR54_RS18945	COG3181	Tripartite tricarboxylate transporter family receptor
ACR54_RS18955	COG0114	fumarate hydratase activity
ACR54_RS18965	COG0860	N-Acetylmuramoyl-L-alanine amidase
ACR54_RS18970	COG3064	Membrane
ACR54_RS18970	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
ACR54_RS18970	COG3064	Membrane
ACR54_RS18970	COG3210	domain, Protein
ACR54_RS18970	COG3210	domain, Protein
ACR54_RS18970	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
ACR54_RS18975	COG0586	Pfam SNARE associated Golgi protein
ACR54_RS18980	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ACR54_RS18985	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ACR54_RS18990	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ACR54_RS19005	COG0617	tRNA 3'-terminal CCA addition
ACR54_RS19035	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
ACR54_RS19045	COG1024	Enoyl-CoA hydratase
ACR54_RS19050	COG0752	glycyl-tRNA synthetase alpha subunit
ACR54_RS19055	COG0751	glycine-tRNA ligase activity
ACR54_RS19060	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ACR54_RS19065	COG0204	Acyl-transferase
ACR54_RS19075	COG0583	DNA-binding transcription factor activity
ACR54_RS19080	COG1053	succinate dehydrogenase
ACR54_RS19080	COG3976	FMN-binding domain protein
ACR54_RS19100	COG0242	peptide deformylase activity
ACR54_RS19105	COG1960	acyl-CoA dehydrogenase activity
ACR54_RS19110	COG0700	Nucleoside recognition
ACR54_RS19115	COG0469	pyruvate kinase activity
ACR54_RS19120	COG1929	Belongs to the glycerate kinase type-1 family
ACR54_RS19130	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ACR54_RS19135	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ACR54_RS19140	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
ACR54_RS19150	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ACR54_RS19160	COG2154	pterin-4-alpha-carbinolamine dehydratase
ACR54_RS19175	COG0667	Aldo Keto reductase
ACR54_RS19185	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ACR54_RS19190	COG4106	trans-aconitate 2-methyltransferase activity
ACR54_RS19200	COG0737	Belongs to the 5'-nucleotidase family
ACR54_RS19205	COG0583	DNA-binding transcription factor activity
ACR54_RS19220	COG0410	ABC transporter
ACR54_RS19235	COG0559	Belongs to the binding-protein-dependent transport system permease family
ACR54_RS19250	COG1215	transferase activity, transferring glycosyl groups
ACR54_RS19295	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
ACR54_RS19300	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ACR54_RS19330	COG2982	Protein involved in outer membrane biogenesis
ACR54_RS19335	COG2818	Glycosylase
ACR54_RS19340	COG0727	PFAM Uncharacterised protein family (UPF0153)
ACR54_RS19365	COG0402	S-adenosylhomocysteine deaminase activity
ACR54_RS19370	COG3321	synthase
ACR54_RS19370	COG1028	Short-chain dehydrogenase reductase Sdr
ACR54_RS19370	COG0604	alcohol dehydrogenase
ACR54_RS19375	COG0156	8-amino-7-oxononanoate synthase activity
ACR54_RS19380	COG2877	3-deoxy-8-phosphooctulonate synthase activity
ACR54_RS19400	COG0300	oxidoreductase activity
ACR54_RS19415	COG2011	ABC-type metal ion transport system permease component
ACR54_RS19420	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ACR54_RS19425	COG1501	Belongs to the glycosyl hydrolase 31 family
ACR54_RS19430	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
ACR54_RS19430	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ACR54_RS19440	COG0318	PFAM AMP-dependent synthetase and ligase
ACR54_RS19445	COG1473	amidohydrolase
ACR54_RS19450	COG0583	DNA-binding transcription factor activity
ACR54_RS19455	COG2855	membrane
ACR54_RS19465	COG2239	Acts as a magnesium transporter
ACR54_RS19480	COG1522	sequence-specific DNA binding
ACR54_RS19505	COG0653	protein targeting
ACR54_RS19510	COG0739	heme binding
ACR54_RS19525	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
ACR54_RS19540	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ACR54_RS19545	COG1181	Belongs to the D-alanine--D-alanine ligase family
ACR54_RS19550	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ACR54_RS19555	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ACR54_RS19565	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ACR54_RS19570	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ACR54_RS19575	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ACR54_RS19585	COG3116	cell division
ACR54_RS19590	COG0275	rRNA processing
ACR54_RS19595	COG2001	Belongs to the MraZ family
ACR54_RS19600	COG0488	(ABC) transporter
ACR54_RS19605	COG0418	dihydroorotase activity
ACR54_RS19610	COG1473	amidohydrolase
ACR54_RS19660	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ACR54_RS19665	COG4654	Cytochrome c, class I
ACR54_RS19670	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ACR54_RS19700	COG1309	transcriptional regulator
ACR54_RS19705	COG1028	Short-chain dehydrogenase reductase Sdr
ACR54_RS19710	COG2084	Dehydrogenase
ACR54_RS19715	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
ACR54_RS19730	COG1024	Enoyl-CoA hydratase
ACR54_RS19735	COG1414	Transcriptional regulator
ACR54_RS19765	COG0442	prolyl-tRNA aminoacylation
ACR54_RS19770	COG0824	Thioesterase
ACR54_RS19775	COG0811	peptide transport
ACR54_RS19780	COG0848	biopolymer transport protein
ACR54_RS19790	COG0823	Involved in the tonB-independent uptake of proteins
ACR54_RS19810	COG2267	carboxylic ester hydrolase activity
ACR54_RS19815	COG1522	sequence-specific DNA binding
ACR54_RS19825	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ACR54_RS19840	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ACR54_RS19845	COG0697	spore germination
ACR54_RS19855	COG1073	alpha beta
ACR54_RS19865	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ACR54_RS19870	COG0463	Glycosyl transferase, family 2
ACR54_RS19890	COG0842	Transport permease protein
ACR54_RS19895	COG0842	Transport permease protein
ACR54_RS19895	COG1129	ABC transporter
ACR54_RS19900	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ACR54_RS19910	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ACR54_RS19915	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ACR54_RS19925	COG0328	RNA-DNA hybrid ribonuclease activity
ACR54_RS19930	COG2226	methyltransferase
ACR54_RS19935	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ACR54_RS19940	COG1388	LysM domain
ACR54_RS19940	COG0741	lytic transglycosylase activity
ACR54_RS19950	COG2979	Protein of unknown function (DUF533)
ACR54_RS19990	COG1280	lysine exporter protein (LysE YggA)
ACR54_RS19995	COG2816	NAD+ diphosphatase activity
ACR54_RS20010	COG0589	response to stress
ACR54_RS20015	COG2146	nitrite reductase [NAD(P)H] activity
ACR54_RS20015	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ACR54_RS20025	COG2116	formate transmembrane transporter activity
ACR54_RS20030	COG0515	serine threonine protein kinase
ACR54_RS20040	COG3707	response regulator
ACR54_RS20050	COG0165	Argininosuccinate lyase
ACR54_RS20065	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
ACR54_RS20070	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
ACR54_RS20075	COG0251	oxidation-reduction process
ACR54_RS20080	COG0179	Fumarylacetoacetate (FAA) hydrolase
ACR54_RS20095	COG0583	DNA-binding transcription factor activity
ACR54_RS20105	COG0477	Major facilitator Superfamily
ACR54_RS20120	COG4948	Mandelate Racemase Muconate Lactonizing
ACR54_RS20130	COG0477	Major facilitator Superfamily
ACR54_RS20140	COG2719	SpoVR family
ACR54_RS20145	COG2718	Belongs to the UPF0229 family
ACR54_RS20150	COG2766	serine protein kinase
ACR54_RS20160	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ACR54_RS20160	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ACR54_RS20165	COG1335	isochorismatase
ACR54_RS20175	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ACR54_RS20180	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ACR54_RS20190	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ACR54_RS20200	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
ACR54_RS20205	COG0316	Belongs to the HesB IscA family
ACR54_RS20215	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ACR54_RS20220	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ACR54_RS20225	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ACR54_RS20230	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
ACR54_RS20240	COG0312	modulator of DNA gyrase
ACR54_RS20245	COG3028	Belongs to the UPF0307 family
ACR54_RS20270	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ACR54_RS20320	COG0045	succinate-CoA ligase (ADP-forming) activity
ACR54_RS20320	COG0045	succinate-CoA ligase (ADP-forming) activity
ACR54_RS20320	COG1042	CoA-binding domain protein
ACR54_RS20320	COG1042	CoA-binding domain protein
ACR54_RS20320	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ACR54_RS20320	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ACR54_RS20325	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ACR54_RS20330	COG2814	Major facilitator Superfamily
ACR54_RS20340	COG1522	sequence-specific DNA binding
ACR54_RS20370	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ACR54_RS20375	COG1696	Membrane protein involved in D-alanine export
ACR54_RS20395	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ACR54_RS20405	COG2264	protein methyltransferase activity
ACR54_RS20410	COG0439	Biotin carboxylase
ACR54_RS20415	COG0511	ligase activity, forming carbon-carbon bonds
ACR54_RS20420	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ACR54_RS20425	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ACR54_RS20430	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ACR54_RS20435	COG3150	esterase
ACR54_RS20440	COG0557	exoribonuclease II activity
ACR54_RS20450	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ACR54_RS20455	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ACR54_RS20465	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
ACR54_RS20485	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ACR54_RS20490	COG1678	Uncharacterized ACR, COG1678
ACR54_RS20505	COG0352	thiamine-phosphate diphosphorylase activity
ACR54_RS20510	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ACR54_RS20540	COG1024	Enoyl-CoA hydratase
ACR54_RS20545	COG1028	Short-chain dehydrogenase reductase Sdr
ACR54_RS20580	COG0411	ABC transporter
ACR54_RS20615	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
ACR54_RS20625	COG2816	NAD+ diphosphatase activity
ACR54_RS20630	COG3539	Fimbrial protein
ACR54_RS20655	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
ACR54_RS20660	COG0237	dephospho-CoA kinase activity
ACR54_RS20665	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
ACR54_RS20675	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ACR54_RS20680	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
ACR54_RS20690	COG0477	Major facilitator Superfamily
ACR54_RS20710	COG1126	abc transporter atp-binding protein
ACR54_RS20715	COG0765	amino acid transport
ACR54_RS20720	COG4597	amino acid ABC transporter
ACR54_RS20725	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ACR54_RS20730	COG2884	Cell division ATP-binding protein ftsE
ACR54_RS20735	COG2177	Part of the ABC transporter FtsEX involved in
ACR54_RS20740	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
ACR54_RS20750	COG1194	a g-specific adenine glycosylase
ACR54_RS20765	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ACR54_RS20780	COG2226	methyltransferase
ACR54_RS20790	COG4206	TonB-dependent receptor
ACR54_RS20795	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ACR54_RS20800	COG2022	thiamine diphosphate biosynthetic process
ACR54_RS20805	COG0351	phosphomethylpyrimidine kinase
ACR54_RS20810	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
ACR54_RS20815	COG1538	Outer membrane efflux protein
ACR54_RS20820	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ACR54_RS20830	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ACR54_RS20845	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ACR54_RS20875	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ACR54_RS20910	COG1028	Short-chain dehydrogenase reductase Sdr
ACR54_RS20915	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ACR54_RS20930	COG2226	methyltransferase
ACR54_RS20935	COG0745	RESPONSE REGULATOR receiver
ACR54_RS20940	COG5002	protein histidine kinase activity
ACR54_RS20950	COG5002	protein histidine kinase activity
ACR54_RS20960	COG2132	Multicopper oxidase
ACR54_RS20975	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ACR54_RS20990	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
ACR54_RS20995	COG1984	allophanate hydrolase subunit 2
ACR54_RS21005	COG1802	Transcriptional regulator
ACR54_RS21015	COG1238	metal cluster binding
ACR54_RS21020	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ACR54_RS21025	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
ACR54_RS21040	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ACR54_RS21045	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
ACR54_RS21050	COG4988	ABC transporter
ACR54_RS21060	COG1294	oxidase, subunit
ACR54_RS21075	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
ACR54_RS21085	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
ACR54_RS21100	COG1137	ATPase activity
ACR54_RS21105	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ACR54_RS21115	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
ACR54_RS21130	COG1660	Displays ATPase and GTPase activities
ACR54_RS21150	COG0792	nuclease activity
ACR54_RS21155	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
ACR54_RS21160	COG2823	Periplasmic or secreted lipoprotein
ACR54_RS21175	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ACR54_RS21185	COG1309	transcriptional regulator
ACR54_RS21190	COG0471	metal ion transport
ACR54_RS21195	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
ACR54_RS21200	COG0772	Belongs to the SEDS family
ACR54_RS21205	COG0768	penicillin binding
ACR54_RS21215	COG1792	Involved in formation and maintenance of cell shape
ACR54_RS21220	COG1077	Cell shape determining protein MreB Mrl
ACR54_RS21225	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ACR54_RS21230	COG0154	amidase activity
ACR54_RS21235	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ACR54_RS21240	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ACR54_RS21245	COG0708	Exodeoxyribonuclease III
ACR54_RS21250	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ACR54_RS21255	COG2860	membrane
ACR54_RS21265	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
ACR54_RS21270	COG2223	nitrite transmembrane transporter activity
ACR54_RS21275	COG2813	Specifically methylates the guanine in position
ACR54_RS21275	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ACR54_RS21280	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ACR54_RS21285	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
ACR54_RS21305	COG2918	glutathione biosynthetic process
ACR54_RS21330	COG3245	cytochrome
ACR54_RS21335	COG1250	3-hydroxyacyl-CoA dehydrogenase
ACR54_RS21345	COG1960	acyl-CoA dehydrogenase activity
ACR54_RS21350	COG1309	transcriptional regulator
ACR54_RS21355	COG2070	2-Nitropropane dioxygenase
ACR54_RS21360	COG1024	Enoyl-CoA hydratase
ACR54_RS21365	COG1024	Enoyl-CoA hydratase
ACR54_RS21370	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ACR54_RS21380	COG0747	negative chemotaxis
ACR54_RS21390	COG0601	transmembrane transport
ACR54_RS21395	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ACR54_RS21400	COG0444	Belongs to the ABC transporter superfamily
ACR54_RS21405	COG4608	Belongs to the ABC transporter superfamily
ACR54_RS21420	COG0210	DNA helicase
ACR54_RS21425	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ACR54_RS21430	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ACR54_RS21440	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ACR54_RS21445	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ACR54_RS21450	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ACR54_RS21455	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ACR54_RS21460	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ACR54_RS21465	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ACR54_RS21475	COG0356	it plays a direct role in the translocation of protons across the membrane
ACR54_RS21490	COG1024	Enoyl-CoA hydratase
ACR54_RS21510	COG0037	tRNA processing
ACR54_RS21520	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ACR54_RS21525	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ACR54_RS21530	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
ACR54_RS21535	COG2967	ApaG domain
ACR54_RS21540	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ACR54_RS21545	COG0546	phosphoglycolate phosphatase activity
ACR54_RS21555	COG0512	Glutamine amidotransferase of anthranilate synthase
ACR54_RS21560	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ACR54_RS21565	COG0134	indole-3-glycerol-phosphate synthase activity
ACR54_RS21575	COG1028	Short-chain dehydrogenase reductase Sdr
ACR54_RS21585	COG0583	DNA-binding transcription factor activity
ACR54_RS21605	COG3276	selenocysteine insertion sequence binding
ACR54_RS21620	COG2864	formate dehydrogenase
ACR54_RS21625	COG0437	4 iron, 4 sulfur cluster binding
ACR54_RS21630	COG3383	formate dehydrogenase (NAD+) activity
ACR54_RS21630	COG0243	molybdopterin cofactor binding
ACR54_RS21635	COG0243	molybdopterin cofactor binding
ACR54_RS21635	COG3383	formate dehydrogenase (NAD+) activity
ACR54_RS21645	COG1607	acyl-coa hydrolase
ACR54_RS21675	COG1595	DNA-templated transcription, initiation
ACR54_RS21680	COG3712	iron ion homeostasis
ACR54_RS21690	COG3720	iron ion transport
ACR54_RS21695	COG4558	Periplasmic binding protein
ACR54_RS21700	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ACR54_RS21705	COG1120	ATPase activity
ACR54_RS21720	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ACR54_RS21725	COG1683	Conserved Protein
ACR54_RS21735	COG1335	isochorismatase
ACR54_RS21740	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ACR54_RS21745	COG1473	amidohydrolase
ACR54_RS21755	COG0583	DNA-binding transcription factor activity
ACR54_RS21765	COG3145	DNA-N1-methyladenine dioxygenase activity
ACR54_RS21770	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ACR54_RS21770	COG2169	Transcriptional regulator
ACR54_RS21790	COG3181	Tripartite tricarboxylate transporter family receptor
ACR54_RS21800	COG0443	Heat shock 70 kDa protein
ACR54_RS21805	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ACR54_RS21830	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
ACR54_RS21835	COG1671	Belongs to the UPF0178 family
ACR54_RS21845	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ACR54_RS21920	COG1902	pentaerythritol trinitrate reductase activity
ACR54_RS21930	COG0559	Belongs to the binding-protein-dependent transport system permease family
ACR54_RS21965	COG2124	cytochrome p450
ACR54_RS22060	COG1522	sequence-specific DNA binding
ACR54_RS22075	COG2814	Major facilitator Superfamily
ACR54_RS22080	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ACR54_RS22100	COG1999	signal sequence binding
ACR54_RS22105	COG0109	protoheme IX farnesyltransferase activity
ACR54_RS22145	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ACR54_RS22155	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
ACR54_RS22160	COG1609	Transcriptional regulator
ACR54_RS22170	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
ACR54_RS22175	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ACR54_RS22190	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
ACR54_RS22205	COG0070	glutamate synthase
ACR54_RS22205	COG0069	glutamate synthase activity
ACR54_RS22205	COG0067	glutamate synthase
ACR54_RS22215	COG3047	cAMP biosynthetic process
ACR54_RS22220	COG1127	ABC transporter
ACR54_RS22225	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ACR54_RS22230	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
ACR54_RS22245	COG1131	(ABC) transporter
ACR54_RS22250	COG0842	Transport permease protein
ACR54_RS22255	COG0271	Belongs to the BolA IbaG family
ACR54_RS22260	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ACR54_RS22265	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ACR54_RS22270	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ACR54_RS22275	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ACR54_RS22280	COG0131	Imidazoleglycerol-phosphate dehydratase
ACR54_RS22290	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ACR54_RS22295	COG0107	imidazoleglycerol-phosphate synthase activity
ACR54_RS22300	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ACR54_RS22305	COG0140	phosphoribosyl-ATP diphosphatase activity
ACR54_RS22310	COG0537	adenosine 5'-monophosphoramidase activity
ACR54_RS22315	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ACR54_RS22320	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ACR54_RS22330	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ACR54_RS22335	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ACR54_RS22340	COG1970	mechanosensitive ion channel activity
ACR54_RS22345	COG0723	plastoquinol--plastocyanin reductase activity
ACR54_RS22350	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ACR54_RS22355	COG2857	Cytochrome c1
ACR54_RS22360	COG0625	glutathione transferase activity
ACR54_RS22365	COG2969	positive regulation of protein catabolic process
ACR54_RS22375	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
ACR54_RS22390	COG0697	spore germination
ACR54_RS22410	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ACR54_RS22420	COG0601	transmembrane transport
ACR54_RS22425	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ACR54_RS22435	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
ACR54_RS22445	COG0513	Belongs to the DEAD box helicase family
ACR54_RS22450	COG1280	lysine exporter protein (LysE YggA)
ACR54_RS22455	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
ACR54_RS22475	COG0583	DNA-binding transcription factor activity
ACR54_RS22485	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
ACR54_RS22495	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ACR54_RS22500	COG0154	amidase activity
ACR54_RS22525	COG3842	ATPase activity
ACR54_RS22530	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
ACR54_RS22535	COG3842	ATPase activity
ACR54_RS22540	COG1653	transport
ACR54_RS22545	COG1175	transmembrane transport
ACR54_RS22550	COG0395	ABC-type sugar transport system, permease component
ACR54_RS22565	COG0018	arginyl-trna synthetase
ACR54_RS22575	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ACR54_RS22580	COG2200	EAL domain
ACR54_RS22610	COG1473	amidohydrolase
ACR54_RS22615	COG1960	acyl-CoA dehydrogenase activity
ACR54_RS22620	COG0183	Belongs to the thiolase family
ACR54_RS22625	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ACR54_RS22640	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ACR54_RS22650	COG2358	TRAP transporter, solute receptor (TAXI family
ACR54_RS22660	COG1629	transport
ACR54_RS22665	COG2922	Belongs to the Smg family
ACR54_RS22670	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ACR54_RS22690	COG3842	ATPase activity
ACR54_RS22695	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ACR54_RS22700	COG1028	Short-chain dehydrogenase reductase Sdr
ACR54_RS22705	COG1012	belongs to the aldehyde dehydrogenase family
ACR54_RS22715	COG0028	Belongs to the TPP enzyme family
ACR54_RS22720	COG1522	sequence-specific DNA binding
ACR54_RS22725	COG3781	membrane
ACR54_RS22735	COG0702	epimerase
ACR54_RS22755	COG2910	NAD(P)H-binding
ACR54_RS22760	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ACR54_RS22775	COG3845	ABC transporter
ACR54_RS22780	COG4603	Belongs to the binding-protein-dependent transport system permease family
ACR54_RS22785	COG1079	Belongs to the binding-protein-dependent transport system permease family
ACR54_RS22790	COG0402	S-adenosylhomocysteine deaminase activity
ACR54_RS22795	COG0625	glutathione transferase activity
ACR54_RS22805	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ACR54_RS22830	COG1960	acyl-CoA dehydrogenase activity
ACR54_RS22835	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ACR54_RS22850	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
ACR54_RS22855	COG1304	FMN binding
ACR54_RS22860	COG1254	Belongs to the acylphosphatase family
ACR54_RS22865	COG1309	transcriptional regulator
ACR54_RS22880	COG0592	DNA-directed DNA polymerase activity
ACR54_RS22885	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ACR54_RS22890	COG0230	Belongs to the bacterial ribosomal protein bL34 family
ACR54_RS22895	COG0594	ribonuclease P activity
ACR54_RS22900	COG0706	membrane insertase activity
ACR54_RS22905	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
ACR54_RS22910	COG1473	amidohydrolase
ACR54_RS22915	COG4608	Belongs to the ABC transporter superfamily
ACR54_RS22920	COG0444	Belongs to the ABC transporter superfamily
ACR54_RS22925	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ACR54_RS22930	COG0601	transmembrane transport
ACR54_RS22940	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ACR54_RS22945	COG1505	serine-type exopeptidase activity
ACR54_RS22955	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
ACR54_RS22965	COG0179	Fumarylacetoacetate (FAA) hydrolase
ACR54_RS22975	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ACR54_RS22980	COG3181	Tripartite tricarboxylate transporter family receptor
ACR54_RS22995	COG0281	malic enzyme
ACR54_RS22995	COG0280	phosphate acetyltransferase
ACR54_RS23025	COG0583	DNA-binding transcription factor activity
ACR54_RS23030	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ACR54_RS23040	COG0436	Aminotransferase
ACR54_RS23045	COG1278	Cold shock
ACR54_RS23065	COG2188	Transcriptional regulator
ACR54_RS23070	COG5002	protein histidine kinase activity
ACR54_RS23070	COG2205	protein histidine kinase activity
ACR54_RS23070	COG0784	Response regulator, receiver