locus-tag	class	description
D558_RS00040	COG2963	transposase activity
D558_RS00045	COG2801	Transposase and inactivated derivatives
D558_RS00060	COG2801	Transposase and inactivated derivatives
D558_RS00080	COG1846	Transcriptional regulator
D558_RS00090	COG1566	PFAM secretion protein HlyD family protein
D558_RS00095	COG2814	Major facilitator Superfamily
D558_RS00120	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D558_RS00125	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D558_RS00130	COG0433	COG0433 Predicted ATPase
D558_RS00135	COG0217	transcriptional regulatory protein
D558_RS00140	COG0151	Belongs to the GarS family
D558_RS00155	COG0799	negative regulation of ribosome biogenesis
D558_RS00160	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
D558_RS00165	COG0424	maF-like protein
D558_RS00175	COG4191	Histidine kinase
D558_RS00180	COG2204	response regulator
D558_RS00205	COG0500	methyltransferase
D558_RS00230	COG1121	(ABC) transporter
D558_RS00235	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D558_RS00240	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D558_RS00255	COG4993	Dehydrogenase
D558_RS00265	COG4772	TonB-dependent receptor
D558_RS00270	COG2814	Major facilitator Superfamily
D558_RS00290	COG0037	tRNA processing
D558_RS00295	COG0825	malonyl-CoA metabolic process
D558_RS00305	COG0215	cysteine-tRNA ligase activity
D558_RS00315	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D558_RS00320	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D558_RS00325	COG1968	undecaprenyl-diphosphatase activity
D558_RS00330	COG1253	flavin adenine dinucleotide binding
D558_RS00335	COG0483	inositol monophosphate 1-phosphatase activity
D558_RS00355	COG0668	transmembrane transport
D558_RS00380	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D558_RS00390	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
D558_RS00405	COG1802	Transcriptional regulator
D558_RS00425	COG3360	Dodecin
D558_RS00445	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
D558_RS00450	COG2850	peptidyl-arginine hydroxylation
D558_RS00460	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
D558_RS00465	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D558_RS00470	COG1994	Peptidase M50
D558_RS00475	COG0009	L-threonylcarbamoyladenylate synthase
D558_RS00480	COG2321	neutral zinc metallopeptidase
D558_RS00500	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D558_RS00510	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D558_RS00515	COG2271	Major facilitator Superfamily
D558_RS00540	COG2801	Transposase and inactivated derivatives
D558_RS00545	COG2963	transposase activity
D558_RS00595	COG2200	EAL domain
D558_RS00595	COG2199	diguanylate cyclase activity
D558_RS00595	COG2202	Pas domain
D558_RS00600	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
D558_RS00620	COG1960	acyl-CoA dehydrogenase activity
D558_RS00625	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D558_RS00630	COG2186	Transcriptional regulator
D558_RS00655	COG1595	DNA-templated transcription, initiation
D558_RS00675	COG2801	Transposase and inactivated derivatives
D558_RS00690	COG1028	Short-chain dehydrogenase reductase Sdr
D558_RS00700	COG0179	Fumarylacetoacetate (FAA) hydrolase
D558_RS00720	COG4604	ABC transporter, ATP-binding protein
D558_RS00725	COG4605	iron ion homeostasis
D558_RS00735	COG4607	ABC-type enterochelin transport system periplasmic component
D558_RS00740	COG0438	transferase activity, transferring glycosyl groups
D558_RS00750	COG0149	triose-phosphate isomerase activity
D558_RS00755	COG0604	alcohol dehydrogenase
D558_RS00755	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D558_RS00755	COG3321	synthase
D558_RS00755	COG4221	oxidoreductase activity
D558_RS00790	COG0668	transmembrane transport
D558_RS00805	COG0789	Transcriptional regulator
D558_RS00815	COG0501	Belongs to the peptidase M48B family
D558_RS00845	COG1024	Enoyl-CoA hydratase
D558_RS00850	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D558_RS00870	COG3468	outer membrane autotransporter barrel domain protein
D558_RS00875	COG2801	Transposase and inactivated derivatives
D558_RS00880	COG2801	Transposase and inactivated derivatives
D558_RS00910	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
D558_RS00920	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
D558_RS00925	COG1674	ftsk spoiiie
D558_RS00930	COG0492	ferredoxin-NADP+ reductase activity
D558_RS00935	COG1193	negative regulation of DNA recombination
D558_RS00950	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D558_RS00960	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
D558_RS00970	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
D558_RS00975	COG2205	protein histidine kinase activity
D558_RS00980	COG0745	RESPONSE REGULATOR receiver
D558_RS01035	COG0612	Peptidase, M16
D558_RS01045	COG0443	Heat shock 70 kDa protein
D558_RS01055	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
D558_RS01065	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
D558_RS01070	COG1420	regulation of RNA biosynthetic process
D558_RS01075	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
D558_RS01080	COG0497	DNA recombination
D558_RS01090	COG2801	Transposase and inactivated derivatives
D558_RS01105	COG0735	belongs to the Fur family
D558_RS01110	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D558_RS01130	COG2801	Transposase and inactivated derivatives
D558_RS01140	COG2801	Transposase and inactivated derivatives
D558_RS01160	COG2828	Protein conserved in bacteria
D558_RS01165	COG1280	lysine exporter protein (LysE YggA)
D558_RS01170	COG3181	Tripartite tricarboxylate transporter family receptor
D558_RS01185	COG1028	Short-chain dehydrogenase reductase Sdr
D558_RS01190	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
D558_RS01200	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
D558_RS01205	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D558_RS01210	COG1335	isochorismatase
D558_RS01245	COG0583	DNA-binding transcription factor activity
D558_RS01255	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
D558_RS01260	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
D558_RS01265	COG0167	dihydroorotate dehydrogenase activity
D558_RS01280	COG2801	Transposase and inactivated derivatives
D558_RS01305	COG1414	Transcriptional regulator
D558_RS01325	COG0513	Belongs to the DEAD box helicase family
D558_RS01380	COG2801	Transposase and inactivated derivatives
D558_RS01405	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D558_RS01435	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
D558_RS01440	COG0632	four-way junction helicase activity
D558_RS01455	COG2255	four-way junction helicase activity
D558_RS01460	COG0514	ATP-dependent DNA helicase (RecQ)
D558_RS01480	COG1294	oxidase, subunit
D558_RS01490	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D558_RS01500	COG2894	cell division
D558_RS01505	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
D558_RS01525	COG0488	(ABC) transporter
D558_RS01540	COG4608	Belongs to the ABC transporter superfamily
D558_RS01545	COG0444	Belongs to the ABC transporter superfamily
D558_RS01550	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D558_RS01565	COG1215	transferase activity, transferring glycosyl groups
D558_RS01570	COG0583	DNA-binding transcription factor activity
D558_RS01575	COG1368	sulfuric ester hydrolase activity
D558_RS01580	COG1686	Belongs to the peptidase S11 family
D558_RS01590	COG1280	lysine exporter protein (LysE YggA)
D558_RS01600	COG1064	alcohol dehydrogenase
D558_RS01605	COG4191	Histidine kinase
D558_RS01610	COG4566	intracellular signal transduction
D558_RS01620	COG1802	Transcriptional regulator
D558_RS01645	COG3181	Tripartite tricarboxylate transporter family receptor
D558_RS01650	COG0513	Belongs to the DEAD box helicase family
D558_RS01655	COG0668	transmembrane transport
D558_RS01670	COG1595	DNA-templated transcription, initiation
D558_RS01715	COG0531	amino acid
D558_RS01720	COG1982	Orn Lys Arg decarboxylase major
D558_RS01740	COG2801	Transposase and inactivated derivatives
D558_RS01750	COG0459	protein refolding
D558_RS01760	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
D558_RS01765	COG1252	NADH dehydrogenase
D558_RS01770	COG0284	orotidine-5'-phosphate decarboxylase activity
D558_RS01790	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D558_RS01795	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
D558_RS01825	COG1595	DNA-templated transcription, initiation
D558_RS01835	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
D558_RS01840	COG3639	organic phosphonate transmembrane transporter activity
D558_RS01845	COG3639	organic phosphonate transmembrane transporter activity
D558_RS01860	COG0742	ribosomal rna small subunit methyltransferase
D558_RS01865	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
D558_RS01870	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
D558_RS01875	COG3135	benzoate transporter
D558_RS01895	COG4774	siderophore transport
D558_RS01920	COG1024	Enoyl-CoA hydratase
D558_RS01925	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D558_RS01930	COG1960	acyl-CoA dehydrogenase activity
D558_RS01940	COG0318	PFAM AMP-dependent synthetase and ligase
D558_RS01945	COG3181	Tripartite tricarboxylate transporter family receptor
D558_RS01955	COG0583	DNA-binding transcription factor activity
D558_RS01980	COG0277	FAD linked oxidase domain protein
D558_RS02000	COG1802	Transcriptional regulator
D558_RS02010	COG2271	Major facilitator Superfamily
D558_RS02020	COG0583	DNA-binding transcription factor activity
D558_RS02025	COG4774	siderophore transport
D558_RS02045	COG0012	GTP binding
D558_RS02055	COG0193	aminoacyl-tRNA hydrolase activity
D558_RS02060	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
D558_RS02065	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D558_RS02075	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
D558_RS02090	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
D558_RS02100	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D558_RS02130	COG1368	sulfuric ester hydrolase activity
D558_RS02135	COG2186	Transcriptional regulator
D558_RS02145	COG3181	Tripartite tricarboxylate transporter family receptor
D558_RS02160	COG0277	FAD linked oxidase domain protein
D558_RS02175	COG0166	Belongs to the GPI family
D558_RS02180	COG0438	transferase activity, transferring glycosyl groups
D558_RS02200	COG0438	transferase activity, transferring glycosyl groups
D558_RS02215	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
D558_RS02220	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D558_RS02230	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
D558_RS02240	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
D558_RS02250	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D558_RS02255	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D558_RS02270	COG0747	negative chemotaxis
D558_RS02280	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D558_RS02285	COG4172	Belongs to the ABC transporter superfamily
D558_RS02305	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D558_RS02305	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D558_RS02310	COG0509	glycine decarboxylation via glycine cleavage system
D558_RS02315	COG0404	The glycine cleavage system catalyzes the degradation of glycine
D558_RS02320	COG2081	HI0933 family
D558_RS02335	COG0456	acetyltransferase
D558_RS02340	COG0717	Belongs to the dCTP deaminase family
D558_RS02355	COG0489	protein tyrosine kinase activity
D558_RS02365	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D558_RS02365	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D558_RS02390	COG3539	Fimbrial protein
D558_RS02405	COG0745	RESPONSE REGULATOR receiver
D558_RS02425	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D558_RS02430	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
D558_RS02445	COG2084	Dehydrogenase
D558_RS02450	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D558_RS02475	COG3842	ATPase activity
D558_RS02480	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
D558_RS02495	COG0583	DNA-binding transcription factor activity
D558_RS02505	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D558_RS02510	COG1024	Enoyl-CoA hydratase
D558_RS02525	COG0583	DNA-binding transcription factor activity
D558_RS02530	COG1408	metallophosphoesterase
D558_RS02570	COG0426	domain, Protein
D558_RS02570	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D558_RS02575	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D558_RS02580	COG0583	DNA-binding transcription factor activity
D558_RS02590	COG1024	Enoyl-CoA hydratase
D558_RS02600	COG1960	acyl-CoA dehydrogenase activity
D558_RS02605	COG1028	Short-chain dehydrogenase reductase Sdr
D558_RS02625	COG3181	Tripartite tricarboxylate transporter family receptor
D558_RS02630	COG1028	Short-chain dehydrogenase reductase Sdr
D558_RS02640	COG3181	Tripartite tricarboxylate transporter family receptor
D558_RS02680	COG0583	DNA-binding transcription factor activity
D558_RS02685	COG1960	acyl-CoA dehydrogenase activity
D558_RS02690	COG3181	Tripartite tricarboxylate transporter family receptor
D558_RS02700	COG0220	tRNA (guanine-N7-)-methyltransferase activity
D558_RS02720	COG2801	Transposase and inactivated derivatives
D558_RS02725	COG0560	Phosphoserine phosphatase
D558_RS02730	COG0583	DNA-binding transcription factor activity
D558_RS02740	COG3842	ATPase activity
D558_RS02755	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
D558_RS02775	COG0625	glutathione transferase activity
D558_RS02820	COG4336	lyase activity
D558_RS02830	COG0326	Molecular chaperone. Has ATPase activity
D558_RS02835	COG2233	PERMEase
D558_RS02855	COG2801	Transposase and inactivated derivatives
D558_RS02870	COG2982	Protein involved in outer membrane biogenesis
D558_RS02875	COG2982	Protein involved in outer membrane biogenesis
D558_RS02880	COG2818	Glycosylase
D558_RS02885	COG0727	PFAM Uncharacterised protein family (UPF0153)
D558_RS02910	COG0402	S-adenosylhomocysteine deaminase activity
D558_RS02920	COG0156	8-amino-7-oxononanoate synthase activity
D558_RS02925	COG2877	3-deoxy-8-phosphooctulonate synthase activity
D558_RS02950	COG2801	Transposase and inactivated derivatives
D558_RS02975	COG1464	Belongs to the NlpA lipoprotein family
D558_RS02980	COG2011	ABC-type metal ion transport system permease component
D558_RS02985	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D558_RS02990	COG1501	Belongs to the glycosyl hydrolase 31 family
D558_RS02995	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
D558_RS02995	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D558_RS03000	COG0483	inositol monophosphate 1-phosphatase activity
D558_RS03005	COG0318	PFAM AMP-dependent synthetase and ligase
D558_RS03010	COG1473	amidohydrolase
D558_RS03015	COG0583	DNA-binding transcription factor activity
D558_RS03020	COG2855	membrane
D558_RS03030	COG2239	Acts as a magnesium transporter
D558_RS03045	COG1522	sequence-specific DNA binding
D558_RS03065	COG2801	Transposase and inactivated derivatives
D558_RS03085	COG0330	HflC and HflK could
D558_RS03090	COG0330	HflC and HflK could
D558_RS03095	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D558_RS03100	COG1923	regulation of RNA biosynthetic process
D558_RS03110	COG1160	GTP binding
D558_RS03120	COG2976	Protein conserved in bacteria
D558_RS03125	COG0124	histidyl-tRNA synthetase
D558_RS03140	COG0820	rRNA (adenine-C2-)-methyltransferase activity
D558_RS03145	COG0105	UTP biosynthetic process
D558_RS03150	COG0525	valine-tRNA ligase activity
D558_RS03165	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
D558_RS03170	COG0228	four-way junction DNA binding
D558_RS03175	COG0425	Belongs to the sulfur carrier protein TusA family
D558_RS03230	COG2801	Transposase and inactivated derivatives
D558_RS03245	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D558_RS03250	COG0543	2 iron, 2 sulfur cluster binding
D558_RS03250	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D558_RS03255	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
D558_RS03260	COG2076	Multidrug Resistance protein
D558_RS03265	COG0633	Ferredoxin
D558_RS03265	COG3217	Mosc domain protein beta barrel domain protein
D558_RS03270	COG5285	phytanoyl-CoA dioxygenase
D558_RS03275	COG0662	Cupin 2, conserved barrel domain protein
D558_RS03310	COG2311	Membrane
D558_RS03335	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
D558_RS03345	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
D558_RS03350	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
D558_RS03355	COG1760	l-serine dehydratase
D558_RS03360	COG1283	sodium-dependent phosphate transmembrane transporter activity
D558_RS03365	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D558_RS03370	COG0412	Dienelactone hydrolase
D558_RS03375	COG0428	transporter
D558_RS03385	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
D558_RS03395	COG1845	cytochrome c oxidase, subunit III
D558_RS03400	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
D558_RS03410	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D558_RS03410	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D558_RS03435	COG1942	4-Oxalocrotonate Tautomerase
D558_RS03445	COG4176	ABC-type proline glycine betaine transport system permease component
D558_RS03460	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
D558_RS03465	COG2814	Major facilitator Superfamily
D558_RS03470	COG0227	Belongs to the bacterial ribosomal protein bL28 family
D558_RS03475	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D558_RS03500	COG1846	Transcriptional regulator
D558_RS03505	COG2814	Major facilitator Superfamily
D558_RS03510	COG0495	leucyl-tRNA aminoacylation
D558_RS03525	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
D558_RS03545	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D558_RS03550	COG2274	protein secretion by the type I secretion system
D558_RS03565	COG2801	Transposase and inactivated derivatives
D558_RS03595	COG0427	acetyl-CoA hydrolase
D558_RS03605	COG3264	Mechanosensitive ion channel
D558_RS03605	COG1196	nuclear chromosome segregation
D558_RS03610	COG0730	response to heat
D558_RS03625	COG2176	DNA-directed DNA polymerase activity
D558_RS03650	COG3384	dioxygenase
D558_RS03665	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
D558_RS03690	COG2801	Transposase and inactivated derivatives
D558_RS03775	COG1846	Transcriptional regulator
D558_RS03810	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
D558_RS03820	COG2070	2-Nitropropane dioxygenase
D558_RS03825	COG2070	2-Nitropropane dioxygenase
D558_RS03835	COG2610	gluconate transmembrane transporter activity
D558_RS03850	COG1408	metallophosphoesterase
D558_RS03860	COG2199	diguanylate cyclase activity
D558_RS03900	COG2159	amidohydrolase
D558_RS03910	COG0583	DNA-binding transcription factor activity
D558_RS03925	COG1024	Enoyl-CoA hydratase
D558_RS03930	COG2186	Transcriptional regulator
D558_RS03935	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D558_RS03950	COG2894	cell division
D558_RS03955	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
D558_RS04020	COG1971	Probably functions as a manganese efflux pump
D558_RS04025	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D558_RS04035	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D558_RS04040	COG2814	Major facilitator Superfamily
D558_RS04065	COG4608	Belongs to the ABC transporter superfamily
D558_RS04085	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D558_RS04095	COG3383	formate dehydrogenase (NAD+) activity
D558_RS04110	COG0747	negative chemotaxis
D558_RS04120	COG0625	glutathione transferase activity
D558_RS04150	COG1595	DNA-templated transcription, initiation
D558_RS04190	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
D558_RS04195	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
D558_RS04220	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D558_RS04225	COG1024	Enoyl-CoA hydratase
D558_RS04260	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D558_RS04265	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D558_RS04270	COG1116	anion transmembrane transporter activity
D558_RS04280	COG3585	molybdate ion transport
D558_RS04335	COG0583	DNA-binding transcription factor activity
D558_RS04340	COG4948	Mandelate Racemase Muconate Lactonizing
D558_RS04345	COG3181	Tripartite tricarboxylate transporter family receptor
D558_RS04410	COG4177	L-phenylalanine transmembrane transporter activity
D558_RS04450	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
D558_RS04460	COG0577	efflux transmembrane transporter activity
D558_RS04460	COG1136	(ABC) transporter
D558_RS04465	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D558_RS04480	COG0259	pyridoxamine-phosphate oxidase activity
D558_RS04485	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D558_RS04490	COG0579	oxidoreductase
D558_RS04500	COG0405	Gamma-glutamyltransferase
D558_RS04510	COG3181	Tripartite tricarboxylate transporter family receptor
D558_RS04520	COG0114	fumarate hydratase activity
D558_RS04525	COG0802	atpase or kinase
D558_RS04530	COG0860	N-Acetylmuramoyl-L-alanine amidase
D558_RS04535	COG0586	Pfam SNARE associated Golgi protein
D558_RS04540	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
D558_RS04545	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
D558_RS04550	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
D558_RS04565	COG0617	tRNA 3'-terminal CCA addition
D558_RS04585	COG2801	Transposase and inactivated derivatives
D558_RS04605	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
D558_RS04615	COG1024	Enoyl-CoA hydratase
D558_RS04625	COG2188	Transcriptional regulator
D558_RS04630	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
D558_RS04645	COG0752	glycyl-tRNA synthetase alpha subunit
D558_RS04655	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
D558_RS04660	COG0204	Acyl-transferase
D558_RS04690	COG0242	peptide deformylase activity
D558_RS04700	COG0700	Nucleoside recognition
D558_RS04705	COG0469	pyruvate kinase activity
D558_RS04710	COG1929	Belongs to the glycerate kinase type-1 family
D558_RS04725	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
D558_RS04735	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
D558_RS04745	COG2154	pterin-4-alpha-carbinolamine dehydratase
D558_RS04750	COG2885	chlorophyll binding
D558_RS04760	COG0667	Aldo Keto reductase
D558_RS04770	COG3181	Tripartite tricarboxylate transporter family receptor
D558_RS04790	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D558_RS04795	COG0288	reversible hydration of carbon dioxide
D558_RS04815	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D558_RS04825	COG4829	muconolactone delta-isomerase
D558_RS04830	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
D558_RS04835	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
D558_RS04840	COG1414	Transcriptional regulator
D558_RS04845	COG1028	Short-chain dehydrogenase reductase Sdr
D558_RS04850	COG2031	fatty acid transporter
D558_RS04865	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
D558_RS04870	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
D558_RS04885	COG0129	dihydroxy-acid dehydratase activity
D558_RS04890	COG1609	Transcriptional regulator
D558_RS04910	COG4106	trans-aconitate 2-methyltransferase activity
D558_RS04925	COG0820	rRNA (adenine-C2-)-methyltransferase activity
D558_RS04955	COG2801	Transposase and inactivated derivatives
D558_RS04965	COG0163	prenyltransferase activity
D558_RS04970	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
D558_RS04975	COG2890	protein-(glutamine-N5) methyltransferase activity
D558_RS04980	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
D558_RS04985	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
D558_RS05030	COG0659	secondary active sulfate transmembrane transporter activity
D558_RS05050	COG1028	Short-chain dehydrogenase reductase Sdr
D558_RS05060	COG4774	siderophore transport
D558_RS05070	COG1595	DNA-templated transcription, initiation
D558_RS05085	COG0142	geranyltranstransferase activity
D558_RS05090	COG0261	This protein binds to 23S rRNA in the presence of protein L20
D558_RS05095	COG0211	Belongs to the bacterial ribosomal protein bL27 family
D558_RS05100	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
D558_RS05105	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
D558_RS05125	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D558_RS05125	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D558_RS05130	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
D558_RS05140	COG0583	DNA-binding transcription factor activity
D558_RS05145	COG0861	Integral membrane protein TerC family
D558_RS05160	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D558_RS05165	COG0793	Belongs to the peptidase S41A family
D558_RS05170	COG4942	peptidase
D558_RS05175	COG0588	phosphoglycerate mutase activity
D558_RS05185	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D558_RS05190	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
D558_RS05195	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
D558_RS05200	COG3181	Tripartite tricarboxylate transporter family receptor
D558_RS05215	COG2226	methyltransferase
D558_RS05225	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D558_RS05235	COG2204	response regulator
D558_RS05240	COG5000	phosphorelay sensor kinase activity
D558_RS05250	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
D558_RS05250	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D558_RS05285	COG2188	Transcriptional regulator
D558_RS05300	COG0583	DNA-binding transcription factor activity
D558_RS05305	COG1012	belongs to the aldehyde dehydrogenase family
D558_RS05320	COG0546	phosphoglycolate phosphatase activity
D558_RS05340	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
D558_RS05345	COG0242	peptide deformylase activity
D558_RS05355	COG1522	sequence-specific DNA binding
D558_RS05360	COG2879	small protein
D558_RS05365	COG1966	Carbon starvation protein
D558_RS05395	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D558_RS05400	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D558_RS05405	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
D558_RS05410	COG3181	Tripartite tricarboxylate transporter family receptor
D558_RS05475	COG1172	Belongs to the binding-protein-dependent transport system permease family
D558_RS05510	COG0640	Transcriptional regulator
D558_RS05550	COG0735	belongs to the Fur family
D558_RS05555	COG2207	Transcriptional regulator
D558_RS05560	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
D558_RS05565	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
D558_RS05570	COG0513	Belongs to the DEAD box helicase family
D558_RS05595	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
D558_RS05610	COG1305	Transglutaminase-like
D558_RS05650	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
D558_RS05655	COG1950	PFAM Membrane protein of
D558_RS05680	COG0024	Methionine aminopeptidase
D558_RS05685	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
D558_RS05700	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
D558_RS05710	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
D558_RS05745	COG0735	belongs to the Fur family
D558_RS05750	COG0523	cobalamin synthesis protein
D558_RS05765	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
D558_RS05775	COG2096	Adenosyltransferase
D558_RS05780	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
D558_RS05785	COG0321	lipoyl(octanoyl) transferase activity
D558_RS05795	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D558_RS05800	COG1686	Belongs to the peptidase S11 family
D558_RS05825	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D558_RS05835	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
D558_RS05845	COG0859	PFAM glycosyl transferase family 9
D558_RS05880	COG0477	Major facilitator Superfamily
D558_RS05895	COG3568	Endonuclease Exonuclease Phosphatase
D558_RS05900	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
D558_RS05930	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D558_RS05935	COG1956	GAF domain-containing protein
D558_RS05940	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D558_RS05955	COG2186	Transcriptional regulator
D558_RS05960	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
D558_RS06020	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D558_RS06025	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
D558_RS06060	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
D558_RS06070	COG1028	Short-chain dehydrogenase reductase Sdr
D558_RS06075	COG1012	belongs to the aldehyde dehydrogenase family
D558_RS06080	COG2801	Transposase and inactivated derivatives
D558_RS06100	COG1522	sequence-specific DNA binding
D558_RS06105	COG3781	membrane
D558_RS06125	COG2801	Transposase and inactivated derivatives
D558_RS06130	COG2801	Transposase and inactivated derivatives
D558_RS06150	COG0592	DNA-directed DNA polymerase activity
D558_RS06160	COG0230	Belongs to the bacterial ribosomal protein bL34 family
D558_RS06165	COG0594	ribonuclease P activity
D558_RS06170	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
D558_RS06175	COG0706	membrane insertase activity
D558_RS06180	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
D558_RS06185	COG1473	amidohydrolase
D558_RS06190	COG4608	Belongs to the ABC transporter superfamily
D558_RS06195	COG0444	Belongs to the ABC transporter superfamily
D558_RS06200	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D558_RS06205	COG0601	transmembrane transport
D558_RS06215	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
D558_RS06220	COG1505	serine-type exopeptidase activity
D558_RS06230	COG0280	phosphate acetyltransferase
D558_RS06230	COG0281	malic enzyme
D558_RS06260	COG0436	Aminotransferase
D558_RS06265	COG1278	Cold shock
D558_RS06270	COG0445	tRNA wobble uridine modification
D558_RS06275	COG0357	Ribosomal RNA small subunit methyltransferase G
D558_RS06280	COG1192	Involved in chromosome partitioning
D558_RS06285	COG1475	DNA binding
D558_RS06290	COG0252	asparaginase activity
D558_RS06310	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D558_RS06320	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D558_RS06335	COG0081	regulation of translation
D558_RS06340	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
D558_RS06345	COG0222	ribosome binding
D558_RS06350	COG0085	RNA polymerase activity
D558_RS06355	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
D558_RS06390	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
D558_RS06395	COG0049	tRNA binding
D558_RS06400	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D558_RS06405	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D558_RS06410	COG0051	transcription antitermination factor activity, RNA binding
D558_RS06415	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
D558_RS06420	COG0088	Forms part of the polypeptide exit tunnel
D558_RS06425	COG0089	rRNA binding
D558_RS06430	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
D558_RS06435	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
D558_RS06440	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
D558_RS06445	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
D558_RS06450	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
D558_RS06455	COG0255	Belongs to the universal ribosomal protein uL29 family
D558_RS06460	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
D558_RS06470	COG4177	L-phenylalanine transmembrane transporter activity
D558_RS06485	COG0411	ABC transporter
D558_RS06515	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
D558_RS06520	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
D558_RS06525	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
D558_RS06530	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
D558_RS06535	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
D558_RS06540	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
D558_RS06545	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
D558_RS06550	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
D558_RS06555	COG1841	ribosomal large subunit assembly
D558_RS06560	COG0200	Binds to the 23S rRNA
D558_RS06565	COG0201	protein transport
D558_RS06570	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
D558_RS06575	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
D558_RS06580	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
D558_RS06585	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
D558_RS06590	COG0202	RNA polymerase activity
D558_RS06595	COG0203	ribosomal protein L17
D558_RS06600	COG0537	adenosine 5'-monophosphoramidase activity
D558_RS06605	COG1324	tolerance protein
D558_RS06610	COG4232	protein-disulfide reductase activity
D558_RS06625	COG0218	Necessary for normal cell division and for the maintenance of normal septation
D558_RS06635	COG1333	cytochrome c biogenesis protein
D558_RS06640	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D558_RS06650	COG1965	Belongs to the frataxin family
D558_RS06660	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
D558_RS06665	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
D558_RS06670	COG0232	Belongs to the dGTPase family. Type 2 subfamily
D558_RS06690	COG2814	Major facilitator Superfamily
D558_RS06710	COG2801	Transposase and inactivated derivatives
D558_RS06755	COG2922	Belongs to the Smg family
D558_RS06770	COG2358	TRAP transporter, solute receptor (TAXI family
D558_RS06780	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D558_RS06795	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D558_RS06800	COG0183	Belongs to the thiolase family
D558_RS06805	COG1960	acyl-CoA dehydrogenase activity
D558_RS06830	COG2200	EAL domain
D558_RS06835	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D558_RS06845	COG0018	arginyl-trna synthetase
D558_RS06860	COG0154	amidase activity
D558_RS06865	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D558_RS06875	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
D558_RS06885	COG0697	spore germination
D558_RS06915	COG2151	metal-sulfur cluster biosynthetic enzyme
D558_RS06950	COG3350	monooxygenase activity
D558_RS06975	COG1309	transcriptional regulator
D558_RS07005	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
D558_RS07010	COG1280	lysine exporter protein (LysE YggA)
D558_RS07015	COG0513	Belongs to the DEAD box helicase family
D558_RS07025	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
D558_RS07030	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
D558_RS07065	COG0625	glutathione transferase activity
D558_RS07070	COG2857	Cytochrome c1
D558_RS07075	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
D558_RS07080	COG0723	plastoquinol--plastocyanin reductase activity
D558_RS07085	COG1970	mechanosensitive ion channel activity
D558_RS07090	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
D558_RS07095	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D558_RS07110	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D558_RS07120	COG0140	phosphoribosyl-ATP diphosphatase activity
D558_RS07125	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
D558_RS07130	COG0107	imidazoleglycerol-phosphate synthase activity
D558_RS07135	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
D558_RS07145	COG0131	Imidazoleglycerol-phosphate dehydratase
D558_RS07150	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D558_RS07155	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
D558_RS07160	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
D558_RS07165	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D558_RS07170	COG0271	Belongs to the BolA IbaG family
D558_RS07175	COG0842	Transport permease protein
D558_RS07180	COG1131	(ABC) transporter
D558_RS07195	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
D558_RS07200	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D558_RS07205	COG1127	ABC transporter
D558_RS07225	COG0070	glutamate synthase
D558_RS07225	COG0069	glutamate synthase activity
D558_RS07225	COG0067	glutamate synthase
D558_RS07245	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
D558_RS07265	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D558_RS07270	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
D558_RS07290	COG2801	Transposase and inactivated derivatives
D558_RS07310	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D558_RS07345	COG0109	protoheme IX farnesyltransferase activity
D558_RS07350	COG1999	signal sequence binding
D558_RS07370	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
D558_RS07375	COG2814	Major facilitator Superfamily
D558_RS07390	COG1522	sequence-specific DNA binding
D558_RS07455	COG3119	arylsulfatase activity
D558_RS07475	COG2801	Transposase and inactivated derivatives
D558_RS07490	COG0402	S-adenosylhomocysteine deaminase activity
D558_RS07500	COG1304	FMN binding
D558_RS07505	COG1254	Belongs to the acylphosphatase family
D558_RS07515	COG3181	Tripartite tricarboxylate transporter family receptor
D558_RS07525	COG1414	Transcriptional regulator
D558_RS07535	COG2801	Transposase and inactivated derivatives
D558_RS07545	COG0028	Belongs to the TPP enzyme family
D558_RS07550	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
D558_RS07555	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D558_RS07560	COG1960	acyl-CoA dehydrogenase activity
D558_RS07570	COG0318	PFAM AMP-dependent synthetase and ligase
D558_RS07595	COG3181	Tripartite tricarboxylate transporter family receptor
D558_RS07600	COG0583	DNA-binding transcription factor activity
D558_RS07615	COG0129	dihydroxy-acid dehydratase activity
D558_RS07620	COG2084	Dehydrogenase
D558_RS07635	COG1671	Belongs to the UPF0178 family
D558_RS07640	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
D558_RS07650	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
D558_RS07655	COG0443	Heat shock 70 kDa protein
D558_RS07675	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D558_RS07675	COG2169	Transcriptional regulator
D558_RS07690	COG1683	Conserved Protein
D558_RS07695	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D558_RS07710	COG1120	ATPase activity
D558_RS07715	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D558_RS07720	COG4558	Periplasmic binding protein
D558_RS07725	COG3720	iron ion transport
D558_RS07735	COG3712	iron ion homeostasis
D558_RS07760	COG1607	acyl-coa hydrolase
D558_RS07780	COG3383	formate dehydrogenase (NAD+) activity
D558_RS07780	COG0243	molybdopterin cofactor binding
D558_RS07785	COG0243	molybdopterin cofactor binding
D558_RS07785	COG3383	formate dehydrogenase (NAD+) activity
D558_RS07790	COG0437	4 iron, 4 sulfur cluster binding
D558_RS07795	COG2864	formate dehydrogenase
D558_RS07850	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
D558_RS07855	COG0512	Glutamine amidotransferase of anthranilate synthase
D558_RS07865	COG0546	phosphoglycolate phosphatase activity
D558_RS07870	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
D558_RS07875	COG2967	ApaG domain
D558_RS07880	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
D558_RS07885	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D558_RS07890	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D558_RS07895	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D558_RS07900	COG0037	tRNA processing
D558_RS07920	COG1024	Enoyl-CoA hydratase
D558_RS07935	COG0356	it plays a direct role in the translocation of protons across the membrane
D558_RS07945	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D558_RS07950	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D558_RS07955	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
D558_RS07960	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
D558_RS07965	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
D558_RS07995	COG0210	DNA helicase
D558_RS08010	COG4608	Belongs to the ABC transporter superfamily
D558_RS08015	COG0444	Belongs to the ABC transporter superfamily
D558_RS08020	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D558_RS08045	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
D558_RS08055	COG1024	Enoyl-CoA hydratase
D558_RS08060	COG2070	2-Nitropropane dioxygenase
D558_RS08075	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D558_RS08080	COG1250	3-hydroxyacyl-CoA dehydrogenase
D558_RS08100	COG2267	carboxylic ester hydrolase activity
D558_RS08120	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
D558_RS08125	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D558_RS08130	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D558_RS08130	COG2813	Specifically methylates the guanine in position
D558_RS08135	COG2223	nitrite transmembrane transporter activity
D558_RS08140	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
D558_RS08155	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D558_RS08160	COG0708	Exodeoxyribonuclease III
D558_RS08165	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
D558_RS08170	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D558_RS08175	COG0154	amidase activity
D558_RS08185	COG1077	Cell shape determining protein MreB Mrl
D558_RS08190	COG1792	Involved in formation and maintenance of cell shape
D558_RS08200	COG0768	penicillin binding
D558_RS08205	COG0772	Belongs to the SEDS family
D558_RS08210	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
D558_RS08215	COG0471	metal ion transport
D558_RS08220	COG1309	transcriptional regulator
D558_RS08230	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
D558_RS08245	COG2823	Periplasmic or secreted lipoprotein
D558_RS08250	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
D558_RS08255	COG0792	nuclease activity
D558_RS08275	COG1660	Displays ATPase and GTPase activities
D558_RS08290	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
D558_RS08300	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
D558_RS08310	COG3181	Tripartite tricarboxylate transporter family receptor
D558_RS08320	COG1137	ATPase activity
D558_RS08335	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
D558_RS08345	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
D558_RS08365	COG1294	oxidase, subunit
D558_RS08375	COG4988	ABC transporter
D558_RS08380	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
D558_RS08385	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D558_RS08400	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D558_RS08405	COG1238	metal cluster binding
D558_RS08425	COG1984	allophanate hydrolase subunit 2
D558_RS08430	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
D558_RS08445	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D558_RS08455	COG0745	RESPONSE REGULATOR receiver
D558_RS08460	COG2226	methyltransferase
D558_RS08495	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D558_RS08505	COG1028	Short-chain dehydrogenase reductase Sdr
D558_RS08525	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
D558_RS08530	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D558_RS08540	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
D558_RS08550	COG2801	Transposase and inactivated derivatives
D558_RS08560	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
D558_RS08565	COG1538	Outer membrane efflux protein
D558_RS08575	COG0351	phosphomethylpyrimidine kinase
D558_RS08580	COG2022	thiamine diphosphate biosynthetic process
D558_RS08585	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D558_RS08600	COG2226	methyltransferase
D558_RS08610	COG1194	a g-specific adenine glycosylase
D558_RS08620	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
D558_RS08625	COG2177	Part of the ABC transporter FtsEX involved in
D558_RS08630	COG2884	Cell division ATP-binding protein ftsE
D558_RS08635	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D558_RS08640	COG4597	amino acid ABC transporter
D558_RS08645	COG0765	amino acid transport
D558_RS08650	COG1126	abc transporter atp-binding protein
D558_RS08690	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
D558_RS08695	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
D558_RS08705	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
D558_RS08710	COG0237	dephospho-CoA kinase activity
D558_RS08715	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
D558_RS08725	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D558_RS08740	COG3539	Fimbrial protein
D558_RS08745	COG3539	Fimbrial protein
D558_RS08760	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
D558_RS08770	COG1846	Transcriptional regulator
D558_RS08835	COG1028	Short-chain dehydrogenase reductase Sdr
D558_RS08840	COG1024	Enoyl-CoA hydratase
D558_RS08845	COG1960	acyl-CoA dehydrogenase activity
D558_RS08875	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
D558_RS08885	COG0351	phosphomethylpyrimidine kinase
D558_RS08890	COG1678	Uncharacterized ACR, COG1678
D558_RS08895	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
D558_RS08925	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
D558_RS08935	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D558_RS08940	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
D558_RS08950	COG0557	exoribonuclease II activity
D558_RS08960	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D558_RS08970	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
D558_RS08980	COG0439	Biotin carboxylase
D558_RS08985	COG2264	protein methyltransferase activity
D558_RS08995	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D558_RS09020	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D558_RS09065	COG1522	sequence-specific DNA binding
D558_RS09080	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D558_RS09140	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
D558_RS09165	COG3028	Belongs to the UPF0307 family
D558_RS09170	COG0312	modulator of DNA gyrase
D558_RS09175	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
D558_RS09180	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
D558_RS09185	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
D558_RS09195	COG0316	Belongs to the HesB IscA family
D558_RS09205	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
D558_RS09215	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D558_RS09220	COG1881	PFAM PEBP family protein
D558_RS09225	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D558_RS09230	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
D558_RS09245	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D558_RS09245	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D558_RS09260	COG2718	Belongs to the UPF0229 family
D558_RS09265	COG2719	SpoVR family
D558_RS09320	COG0477	Major facilitator Superfamily
D558_RS09335	COG0165	Argininosuccinate lyase
D558_RS09340	COG0589	response to stress
D558_RS09350	COG2816	NAD+ diphosphatase activity
D558_RS09355	COG4993	Dehydrogenase
D558_RS09380	COG3181	Tripartite tricarboxylate transporter family receptor
D558_RS09385	COG2979	Protein of unknown function (DUF533)
D558_RS09390	COG4206	TonB-dependent receptor
D558_RS09405	COG0741	lytic transglycosylase activity
D558_RS09405	COG1388	LysM domain
D558_RS09410	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D558_RS09415	COG2226	methyltransferase
D558_RS09445	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D558_RS09460	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D558_RS09465	COG0842	Transport permease protein
D558_RS09465	COG1129	ABC transporter
D558_RS09470	COG0842	Transport permease protein
D558_RS09490	COG0463	Glycosyl transferase, family 2
D558_RS09495	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
D558_RS09505	COG1073	alpha beta
D558_RS09515	COG0697	spore germination
D558_RS09520	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D558_RS09535	COG2801	Transposase and inactivated derivatives
D558_RS09540	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D558_RS09570	COG0823	Involved in the tonB-independent uptake of proteins
D558_RS09580	COG0848	biopolymer transport protein
D558_RS09585	COG0811	peptide transport
D558_RS09590	COG0824	Thioesterase
D558_RS09595	COG0442	prolyl-tRNA aminoacylation
D558_RS09645	COG2084	Dehydrogenase
D558_RS09680	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
D558_RS09685	COG4654	Cytochrome c, class I
D558_RS09690	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D558_RS09740	COG2801	Transposase and inactivated derivatives
D558_RS09755	COG1473	amidohydrolase
D558_RS09760	COG0418	dihydroorotase activity
D558_RS09765	COG0488	(ABC) transporter
D558_RS09770	COG2001	Belongs to the MraZ family
D558_RS09780	COG3116	cell division
D558_RS09790	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
D558_RS09795	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D558_RS09800	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
D558_RS09815	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D558_RS09820	COG1181	Belongs to the D-alanine--D-alanine ligase family
D558_RS09825	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
D558_RS09840	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
D558_RS09860	COG0653	protein targeting
D558_RS09875	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
D558_RS09880	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
D558_RS09890	COG0828	Belongs to the bacterial ribosomal protein bS21 family
D558_RS09915	COG2801	Transposase and inactivated derivatives
D558_RS09925	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
D558_RS09940	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
D558_RS09955	COG0583	DNA-binding transcription factor activity
D558_RS09965	COG3181	Tripartite tricarboxylate transporter family receptor
D558_RS09970	COG2084	Dehydrogenase
D558_RS09980	COG1803	Methylglyoxal synthase
D558_RS09980	COG1597	lipid kinase activity
D558_RS09990	COG0671	phosphoesterase, PA-phosphatase related
D558_RS10010	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
D558_RS10015	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D558_RS10020	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D558_RS10025	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D558_RS10030	COG0649	NAD binding
D558_RS10035	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
D558_RS10045	COG1034	ATP synthesis coupled electron transport
D558_RS10055	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D558_RS10065	COG0713	ATP synthesis coupled electron transport
D558_RS10080	COG1007	ATP synthesis coupled electron transport
D558_RS10090	COG0560	Phosphoserine phosphatase
D558_RS10100	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
D558_RS10105	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
D558_RS10120	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D558_RS10125	COG0450	alkyl hydroperoxide reductase
D558_RS10150	COG1573	uracil-dna glycosylase
D558_RS10155	COG0477	Major facilitator Superfamily
D558_RS10160	COG1196	nuclear chromosome segregation
D558_RS10170	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
D558_RS10175	COG1126	abc transporter atp-binding protein
D558_RS10180	COG0765	amino acid transport
D558_RS10185	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D558_RS10190	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D558_RS10195	COG2917	probably involved in intracellular septation
D558_RS10200	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D558_RS10205	COG1122	ATPase activity
D558_RS10210	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
D558_RS10215	COG1268	BioY protein
D558_RS10245	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D558_RS10265	COG2801	Transposase and inactivated derivatives
D558_RS10270	COG2801	Transposase and inactivated derivatives
D558_RS10280	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
D558_RS10285	COG2878	Part of a membrane complex involved in electron transport
D558_RS10305	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
D558_RS10310	COG0251	oxidation-reduction process
D558_RS10320	COG3228	Belongs to the MtfA family
D558_RS10325	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D558_RS10335	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D558_RS10345	COG0159	tryptophan synthase activity
D558_RS10350	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
D558_RS10355	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
D558_RS10365	COG2801	Transposase and inactivated derivatives
D558_RS10370	COG2801	Transposase and inactivated derivatives
D558_RS10375	COG1530	ribonuclease E activity
D558_RS10380	COG0564	pseudouridine synthase activity
D558_RS10385	COG0546	phosphoglycolate phosphatase activity
D558_RS10390	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
D558_RS10395	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
D558_RS10400	COG3023	N-Acetylmuramoyl-L-alanine amidase
D558_RS10410	COG0424	maF-like protein
D558_RS10420	COG0333	Belongs to the bacterial ribosomal protein bL32 family
D558_RS10430	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D558_RS10440	COG1028	Short-chain dehydrogenase reductase Sdr
D558_RS10445	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D558_RS10450	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D558_RS10475	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D558_RS10490	COG2801	Transposase and inactivated derivatives
D558_RS10505	COG0481	GTPase activity
D558_RS10510	COG0681	Belongs to the peptidase S26 family
D558_RS10515	COG0571	ribonuclease III activity
D558_RS10520	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
D558_RS10525	COG1381	Involved in DNA repair and RecF pathway recombination
D558_RS10540	COG0670	Belongs to the BI1 family
D558_RS10555	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
D558_RS10580	COG0583	DNA-binding transcription factor activity
D558_RS10595	COG0791	NLP P60 protein
D558_RS10605	COG3193	protein, possibly involved in utilization of glycolate and propanediol
D558_RS10665	COG1446	asparaginase
D558_RS10670	COG4172	Belongs to the ABC transporter superfamily
D558_RS10675	COG0747	negative chemotaxis
D558_RS10680	COG0601	transmembrane transport
D558_RS10705	COG0504	CTP synthase activity
D558_RS10730	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
D558_RS10740	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D558_RS10745	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D558_RS10760	COG2801	Transposase and inactivated derivatives
D558_RS10785	COG1981	membrane
D558_RS10805	COG0039	L-malate dehydrogenase activity
D558_RS10810	COG2188	Transcriptional regulator
D558_RS10815	COG2009	succinate dehydrogenase
D558_RS10820	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
D558_RS10825	COG1053	succinate dehydrogenase
D558_RS10835	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
D558_RS10850	COG0583	DNA-binding transcription factor activity
D558_RS10855	COG3842	ATPase activity
D558_RS10865	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D558_RS10870	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D558_RS10880	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D558_RS10890	COG3128	pkhd-type hydroxylase
D558_RS10915	COG1297	OPT oligopeptide transporter protein
D558_RS10920	COG0567	Dehydrogenase, E1 component
D558_RS10930	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D558_RS10935	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
D558_RS10940	COG1595	DNA-templated transcription, initiation
D558_RS10950	COG4774	siderophore transport
D558_RS10975	COG2183	response to ionizing radiation
D558_RS10980	COG1199	ATP-dependent helicase activity
D558_RS10990	COG0564	pseudouridine synthase activity
D558_RS11000	COG3243	poly(R)-hydroxyalkanoic acid synthase
D558_RS11005	COG1028	Short-chain dehydrogenase reductase Sdr
D558_RS11010	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
D558_RS11025	COG0672	)-iron permease
D558_RS11040	COG2823	Periplasmic or secreted lipoprotein
D558_RS11055	COG3237	CsbD-like
D558_RS11060	COG3038	cytochrome b561
D558_RS11075	COG1132	(ABC) transporter
D558_RS11090	COG2833	Protein of unknown function (DUF455)
D558_RS11095	COG2951	lytic endotransglycosylase activity
D558_RS11120	COG0586	Pfam SNARE associated Golgi protein
D558_RS11155	COG2801	Transposase and inactivated derivatives
D558_RS11190	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D558_RS11205	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
D558_RS11210	COG1605	Chorismate mutase
D558_RS11210	COG0077	Prephenate dehydratase
D558_RS11215	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D558_RS11225	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
D558_RS11230	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
D558_RS11250	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
D558_RS11255	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
D558_RS11260	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D558_RS11265	COG0587	DNA-directed DNA polymerase activity
D558_RS11275	COG2951	lytic endotransglycosylase activity
D558_RS11280	COG0123	including yeast histone deacetylase and acetoin utilization protein
D558_RS11300	COG1960	acyl-CoA dehydrogenase activity
D558_RS11305	COG0450	alkyl hydroperoxide reductase
D558_RS11310	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
D558_RS11315	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
D558_RS11320	COG4208	sulfate ABC transporter
D558_RS11325	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
D558_RS11330	COG0175	sulfate reduction
D558_RS11355	COG0335	large ribosomal subunit rRNA binding
D558_RS11375	COG1162	GTPase activity
D558_RS11380	COG0501	Belongs to the peptidase M48B family
D558_RS11385	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
D558_RS11395	COG3327	negative regulation of DNA-templated transcription, initiation
D558_RS11400	COG3396	Phenylacetate-CoA oxygenase
D558_RS11405	COG3460	Phenylacetate-CoA oxygenase
D558_RS11410	COG3396	Phenylacetate-CoA oxygenase
D558_RS11415	COG2151	metal-sulfur cluster biosynthetic enzyme
D558_RS11420	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D558_RS11430	COG1024	Enoyl-CoA hydratase
D558_RS11435	COG2050	protein possibly involved in aromatic compounds catabolism
D558_RS11465	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
D558_RS11465	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D558_RS11485	COG2346	COG2346, Truncated hemoglobins
D558_RS11490	COG3642	lipopolysaccharide core region biosynthetic process
D558_RS11500	COG3842	ATPase activity
D558_RS11505	COG1176	ABC-type spermidine putrescine transport system, permease component I
D558_RS11510	COG1177	transmembrane transport
D558_RS11530	COG1322	Protein conserved in bacteria
D558_RS11540	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
D558_RS11545	COG0704	Plays a role in the regulation of phosphate uptake
D558_RS11550	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
D558_RS11555	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
D558_RS11555	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
D558_RS11560	COG1643	Atp-dependent helicase
D558_RS11575	COG0438	transferase activity, transferring glycosyl groups
D558_RS11580	COG0726	polysaccharide deacetylase
D558_RS11585	COG0463	Glycosyl transferase, family 2
D558_RS11615	COG1132	(ABC) transporter
D558_RS11640	COG0501	Belongs to the peptidase M48B family
D558_RS11685	COG1722	exodeoxyribonuclease VII activity
D558_RS11690	COG0142	geranyltranstransferase activity
D558_RS11700	COG1469	GTP cyclohydrolase I activity
D558_RS11705	COG0360	Binds together with S18 to 16S ribosomal RNA
D558_RS11710	COG2965	DNA replication, synthesis of RNA primer
D558_RS11715	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
D558_RS11720	COG0359	binds to the 23S rRNA
D558_RS11730	COG0305	Participates in initiation and elongation during chromosome replication
D558_RS11740	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
D558_RS11745	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
D558_RS11750	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D558_RS11755	COG3737	Protein of unknown function (DUF498/DUF598)
D558_RS11760	COG0436	Aminotransferase
D558_RS11780	COG2801	Transposase and inactivated derivatives
D558_RS11785	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
D558_RS11790	COG0308	aminopeptidase N
D558_RS11805	COG0312	modulator of DNA gyrase
D558_RS11810	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
D558_RS11825	COG2801	Transposase and inactivated derivatives
D558_RS11835	COG0277	FAD linked oxidase domain protein
D558_RS11840	COG0277	FAD linked oxidase domain protein
D558_RS11845	COG0247	lactate metabolic process
D558_RS11880	COG0583	DNA-binding transcription factor activity
D558_RS11885	COG0482	sulfurtransferase activity
D558_RS11895	COG0625	glutathione transferase activity
D558_RS11900	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
D558_RS11905	COG3909	cytochrome
D558_RS11915	COG2801	Transposase and inactivated derivatives
D558_RS11940	COG3706	GGDEF domain
D558_RS11950	COG2801	Transposase and inactivated derivatives
D558_RS11960	COG2826	transposase and inactivated derivatives, IS30 family
D558_RS12000	COG0069	glutamate synthase activity
D558_RS12005	COG2391	methyltransferase activity
D558_RS12010	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
D558_RS12015	COG0679	Auxin Efflux Carrier
D558_RS12020	COG2153	protein acetylation
D558_RS12040	COG0557	exoribonuclease II activity
D558_RS12050	COG2873	o-acetylhomoserine
D558_RS12055	COG0776	regulation of translation
D558_RS12085	COG0642	Histidine kinase
D558_RS12090	COG3158	transport of potassium into the cell
D558_RS12110	COG2801	Transposase and inactivated derivatives
D558_RS12115	COG0137	argininosuccinate synthase activity
D558_RS12120	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
D558_RS12125	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D558_RS12135	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D558_RS12150	COG2186	Transcriptional regulator
D558_RS12185	COG3836	Belongs to the HpcH HpaI aldolase family
D558_RS12190	COG0268	Binds directly to 16S ribosomal RNA
D558_RS12210	COG2801	Transposase and inactivated derivatives
D558_RS12215	COG2801	Transposase and inactivated derivatives
D558_RS12245	COG0728	peptidoglycan biosynthetic process
D558_RS12255	COG0563	adenylate kinase activity
D558_RS12260	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
D558_RS12265	COG2835	tetraacyldisaccharide 4'-kinase activity
D558_RS12270	COG1663	tetraacyldisaccharide 4'-kinase activity
D558_RS12275	COG0848	biopolymer transport protein
D558_RS12280	COG0811	peptide transport
D558_RS12285	COG1570	exodeoxyribonuclease VII activity
D558_RS12290	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
D558_RS12295	COG2801	Transposase and inactivated derivatives
D558_RS12310	COG0183	Belongs to the thiolase family
D558_RS12320	COG1278	Cold shock
D558_RS12325	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
D558_RS12340	COG4953	penicillin-binding protein 1C
D558_RS12355	COG3008	intermembrane lipid transfer
D558_RS12365	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
D558_RS12365	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
D558_RS12365	COG0506	proline dehydrogenase activity
D558_RS12395	COG0004	ammonium transporteR
D558_RS12400	COG0347	Belongs to the P(II) protein family
D558_RS12430	COG0291	Belongs to the bacterial ribosomal protein bL35 family
D558_RS12435	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
D558_RS12440	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
D558_RS12445	COG0072	phenylalanine-tRNA ligase activity
D558_RS12445	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D558_RS12450	COG0776	regulation of translation
D558_RS12475	COG1802	Transcriptional regulator
D558_RS12480	COG3181	Tripartite tricarboxylate transporter family receptor
D558_RS12490	COG0473	3-isopropylmalate dehydrogenase activity
D558_RS12505	COG1278	Cold shock
D558_RS12515	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D558_RS12535	COG1522	sequence-specific DNA binding
D558_RS12590	COG0656	L-ascorbic acid biosynthetic process
D558_RS12600	COG2801	Transposase and inactivated derivatives
D558_RS12605	COG0656	L-ascorbic acid biosynthetic process
D558_RS12610	COG0667	Aldo Keto reductase
D558_RS12625	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
D558_RS12650	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D558_RS12665	COG1610	YqeY-like protein
D558_RS12680	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D558_RS12685	COG3246	L-lysine catabolic process to acetate
D558_RS12690	COG1250	3-hydroxyacyl-CoA dehydrogenase
D558_RS12700	COG0318	PFAM AMP-dependent synthetase and ligase
D558_RS12715	COG0183	Belongs to the thiolase family
D558_RS12720	COG1024	Enoyl-CoA hydratase
D558_RS12720	COG1250	3-hydroxyacyl-CoA dehydrogenase
D558_RS12730	COG1024	Enoyl-CoA hydratase
D558_RS12730	COG1250	3-hydroxyacyl-CoA dehydrogenase
D558_RS12735	COG0183	Belongs to the thiolase family
D558_RS12740	COG1960	acyl-CoA dehydrogenase activity
D558_RS12765	COG0483	inositol monophosphate 1-phosphatase activity
D558_RS12770	COG1012	belongs to the aldehyde dehydrogenase family
D558_RS12790	COG0210	DNA helicase
D558_RS12795	COG0598	Magnesium transport protein CorA
D558_RS12805	COG0747	negative chemotaxis
D558_RS12810	COG0601	transmembrane transport
D558_RS12815	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D558_RS12820	COG4172	Belongs to the ABC transporter superfamily
D558_RS12840	COG1346	cytolysis
D558_RS12855	COG0783	Belongs to the Dps family
D558_RS12875	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
D558_RS12885	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D558_RS12890	COG1845	cytochrome c oxidase, subunit III
D558_RS12895	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
D558_RS12910	COG2801	Transposase and inactivated derivatives
D558_RS12915	COG2801	Transposase and inactivated derivatives
D558_RS12945	COG1666	GTP binding
D558_RS12970	COG1028	Short-chain dehydrogenase reductase Sdr
D558_RS12975	COG5006	permease, DMT superfamily
D558_RS13040	COG0746	molybdenum cofactor guanylyltransferase activity
D558_RS13045	COG0303	'Molybdopterin
D558_RS13050	COG0521	Mo-molybdopterin cofactor biosynthetic process
D558_RS13055	COG0314	molybdopterin synthase activity
D558_RS13065	COG0315	cyclic pyranopterin monophosphate synthase activity
D558_RS13070	COG0412	Dienelactone hydrolase
D558_RS13080	COG0678	peroxiredoxin activity
D558_RS13095	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D558_RS13115	COG1477	protein flavinylation
D558_RS13140	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D558_RS13145	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
D558_RS13145	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
D558_RS13150	COG1562	ergosterol biosynthetic process
D558_RS13160	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D558_RS13165	COG1028	Short-chain dehydrogenase reductase Sdr
D558_RS13200	COG0254	rRNA binding
D558_RS13205	COG3483	tryptophan 2,3-dioxygenase activity
D558_RS13210	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
D558_RS13215	COG2003	Belongs to the UPF0758 family
D558_RS13225	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
D558_RS13230	COG0625	glutathione transferase activity
D558_RS13260	COG0583	DNA-binding transcription factor activity
D558_RS13270	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
D558_RS13275	COG1187	pseudouridine synthase activity
D558_RS13280	COG0779	Required for maturation of 30S ribosomal subunits
D558_RS13285	COG2251	uridine kinase activity
D558_RS13285	COG0195	Participates in both transcription termination and antitermination
D558_RS13290	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
D558_RS13295	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
D558_RS13300	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
D558_RS13305	COG1217	gtp-binding protein TYPA
D558_RS13320	COG1802	Transcriptional regulator
D558_RS13330	COG1024	Enoyl-CoA hydratase
D558_RS13335	COG0318	PFAM AMP-dependent synthetase and ligase
D558_RS13345	COG2032	superoxide dismutase activity
D558_RS13360	COG4120	Belongs to the binding-protein-dependent transport system permease family
D558_RS13365	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
D558_RS13370	COG0725	ABC transporter, periplasmic molybdate-binding protein
D558_RS13375	COG4149	molybdate abc transporter
D558_RS13405	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D558_RS13410	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D558_RS13415	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D558_RS13425	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
D558_RS13430	COG0736	holo-[acyl-carrier-protein] synthase activity
D558_RS13435	COG1472	Belongs to the glycosyl hydrolase 3 family
D558_RS13440	COG0322	excinuclease ABC activity
D558_RS13445	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D558_RS13455	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
D558_RS13455	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
D558_RS13460	COG2224	Isocitrate lyase
D558_RS13465	COG1846	Transcriptional regulator
D558_RS13470	COG1764	response to oxidative stress
D558_RS13475	COG1131	(ABC) transporter
D558_RS13480	COG0842	Transport permease protein
D558_RS13485	COG0628	permease
D558_RS13500	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
D558_RS13530	COG3015	lipoprotein NlpE involved in copper resistance
D558_RS13540	COG3530	Putative quorum-sensing-regulated virulence factor
D558_RS13555	COG0494	nUDIX hydrolase
D558_RS13565	COG0697	spore germination
D558_RS13570	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
D558_RS13595	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D558_RS13600	COG1702	phosphate starvation-inducible protein PhoH
D558_RS13610	COG4535	Mg2 and Co2 transporter CorC
D558_RS13615	COG0815	Transfers the fatty acyl group on membrane lipoproteins
D558_RS13620	COG0667	Aldo Keto reductase
D558_RS13640	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D558_RS13645	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D558_RS13650	COG1862	Preprotein translocase
D558_RS13665	COG2027	D-alanyl-D-alanine carboxypeptidase
D558_RS13670	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
D558_RS13675	COG1648	precorrin-2 dehydrogenase activity
D558_RS13675	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D558_RS13685	COG4575	ribosome binding
D558_RS13710	COG0741	lytic transglycosylase activity
D558_RS13725	COG0280	phosphate acetyltransferase
D558_RS13725	COG0281	malic enzyme
D558_RS13740	COG1385	rRNA (uridine-N3-)-methyltransferase activity
D558_RS13745	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
D558_RS13750	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D558_RS13755	COG0126	phosphoglycerate kinase activity
D558_RS13775	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
D558_RS13790	COG0625	glutathione transferase activity
D558_RS13810	COG0789	Transcriptional regulator
D558_RS13825	COG0306	phosphate transporter
D558_RS13830	COG0521	Mo-molybdopterin cofactor biosynthetic process
D558_RS13840	COG0739	heme binding
D558_RS13850	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
D558_RS13875	COG2801	Transposase and inactivated derivatives
D558_RS13880	COG2801	Transposase and inactivated derivatives
D558_RS13900	COG0456	acetyltransferase
D558_RS13905	COG1301	dicarboxylic acid transport
D558_RS13915	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
D558_RS13920	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
D558_RS13925	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
D558_RS13930	COG0009	L-threonylcarbamoyladenylate synthase
D558_RS13940	COG4771	TonB-dependent receptor
D558_RS13970	COG1960	acyl-CoA dehydrogenase activity
D558_RS13985	COG4974	Belongs to the 'phage' integrase family
D558_RS13990	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
D558_RS13995	COG1686	Belongs to the peptidase S11 family
D558_RS14030	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
D558_RS14035	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
D558_RS14055	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D558_RS14060	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
D558_RS14065	COG0505	Belongs to the CarA family
D558_RS14070	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D558_RS14080	COG1028	Short-chain dehydrogenase reductase Sdr
D558_RS14085	COG0406	alpha-ribazole phosphatase activity
D558_RS14115	COG2233	PERMEase
D558_RS14120	COG3620	sequence-specific DNA binding
D558_RS14130	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D558_RS14140	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
D558_RS14145	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D558_RS14155	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D558_RS14170	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
D558_RS14185	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D558_RS14200	COG2963	transposase activity
D558_RS14235	COG2801	Transposase and inactivated derivatives
D558_RS14255	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D558_RS14290	COG0540	Belongs to the ATCase OTCase family
D558_RS14295	COG2974	May be involved in recombination
D558_RS14320	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
D558_RS14325	COG2137	regulation of response to DNA damage stimulus
D558_RS14335	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
D558_RS14350	COG0045	succinate-CoA ligase (ADP-forming) activity
D558_RS14355	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
D558_RS14360	COG0861	Integral membrane protein TerC family
D558_RS14365	COG0861	Integral membrane protein TerC family
D558_RS14415	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D558_RS14460	COG1450	Type ii and iii secretion system protein
D558_RS14475	COG2801	Transposase and inactivated derivatives
D558_RS14500	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
D558_RS14505	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D558_RS14515	COG1295	ribonuclease BN
D558_RS14525	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
D558_RS14545	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
D558_RS14550	COG0501	Belongs to the peptidase M48B family
D558_RS14555	COG2197	response regulator
D558_RS14560	COG2801	Transposase and inactivated derivatives
D558_RS14565	COG2801	Transposase and inactivated derivatives
D558_RS14585	COG0066	3-isopropylmalate dehydratase activity
D558_RS14595	COG0473	3-isopropylmalate dehydrogenase activity
D558_RS14600	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D558_RS14610	COG0101	tRNA pseudouridine synthase activity
D558_RS14615	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
D558_RS14620	COG0135	phosphoribosylanthranilate isomerase activity
D558_RS14630	COG2801	Transposase and inactivated derivatives
D558_RS14635	COG2963	transposase activity
D558_RS14640	COG2801	Transposase and inactivated derivatives
D558_RS14660	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D558_RS14665	COG2197	response regulator
D558_RS14670	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
D558_RS14675	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
D558_RS14690	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D558_RS14695	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D558_RS14705	COG1764	response to oxidative stress
D558_RS14720	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D558_RS14725	COG0765	amino acid transport
D558_RS14730	COG0765	amino acid transport
D558_RS14740	COG0756	dUTP diphosphatase activity
D558_RS14775	COG1522	sequence-specific DNA binding
D558_RS14790	COG2801	Transposase and inactivated derivatives
D558_RS14795	COG2801	Transposase and inactivated derivatives
D558_RS14800	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
D558_RS14805	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
D558_RS14810	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
D558_RS14815	COG0196	riboflavin kinase activity
D558_RS14825	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
D558_RS14825	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D558_RS14840	COG2801	Transposase and inactivated derivatives
D558_RS14850	COG0210	DNA helicase
D558_RS14855	COG4771	TonB-dependent receptor
D558_RS14860	COG0488	(ABC) transporter
D558_RS14865	COG2890	protein-(glutamine-N5) methyltransferase activity
D558_RS14875	COG2171	N-acyltransferase activity
D558_RS14925	COG2801	Transposase and inactivated derivatives
D558_RS14945	COG2801	Transposase and inactivated derivatives
D558_RS14995	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D558_RS15000	COG2900	Belongs to the SlyX family
D558_RS15015	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D558_RS15035	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D558_RS15060	COG0257	Belongs to the bacterial ribosomal protein bL36 family
D558_RS15065	COG0583	DNA-binding transcription factor activity
D558_RS15100	COG0508	dehydrogenase complex catalyzes the overall conversion of
D558_RS15105	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
D558_RS15115	COG4566	intracellular signal transduction
D558_RS15120	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
D558_RS15140	COG1999	signal sequence binding
D558_RS15160	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D558_RS15165	COG0583	DNA-binding transcription factor activity
D558_RS15170	COG1187	pseudouridine synthase activity
D558_RS15175	COG3161	chorismate lyase activity
D558_RS15190	COG1280	lysine exporter protein (LysE YggA)
D558_RS15235	COG0583	DNA-binding transcription factor activity
D558_RS15245	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D558_RS15265	COG1185	polyribonucleotide nucleotidyltransferase activity
D558_RS15270	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
D558_RS15285	COG1183	phosphatidylcholine synthase activity
D558_RS15295	COG0440	acetolactate synthase activity
D558_RS15300	COG0028	Belongs to the TPP enzyme family
D558_RS15335	COG1028	Short-chain dehydrogenase reductase Sdr
D558_RS15350	COG3486	L-lysine 6-monooxygenase (NADPH) activity
D558_RS15380	COG2814	Major facilitator Superfamily
D558_RS15400	COG2801	Transposase and inactivated derivatives
D558_RS15405	COG2801	Transposase and inactivated derivatives
D558_RS15420	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D558_RS15455	COG2733	membrane
D558_RS15475	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
D558_RS15495	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D558_RS15500	COG0842	Transport permease protein
D558_RS15500	COG1129	ABC transporter
D558_RS15505	COG0842	Transport permease protein
D558_RS15515	COG1028	Short-chain dehydrogenase reductase Sdr
D558_RS15525	COG2259	Doxx family
D558_RS15555	COG0415	Belongs to the DNA photolyase family
D558_RS15575	COG0386	Belongs to the glutathione peroxidase family
D558_RS15590	COG0095	Lipoate-protein ligase
D558_RS15600	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D558_RS15610	COG0010	Belongs to the arginase family
D558_RS15620	COG0765	amino acid transport
D558_RS15625	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D558_RS15640	COG0084	hydrolase, TatD family'
D558_RS15650	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
D558_RS15655	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
D558_RS15665	COG2175	clavaminate synthase activity
D558_RS15670	COG0583	DNA-binding transcription factor activity
D558_RS15695	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
D558_RS15700	COG1960	acyl-CoA dehydrogenase activity
D558_RS15710	COG2914	Belongs to the UPF0125 (RnfH) family
D558_RS15720	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
D558_RS15755	COG0518	GMP synthase (glutamine-hydrolyzing) activity
D558_RS15755	COG0519	Catalyzes the synthesis of GMP from XMP
D558_RS15765	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
D558_RS15775	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D558_RS15780	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
D558_RS15795	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D558_RS15800	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D558_RS15810	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D558_RS15820	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
D558_RS15830	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D558_RS15835	COG0233	cytoplasmic translational termination
D558_RS15840	COG0528	UMP kinase activity
D558_RS15845	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
D558_RS15850	COG0052	Belongs to the universal ribosomal protein uS2 family
D558_RS15855	COG0024	Methionine aminopeptidase
D558_RS15860	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
D558_RS15870	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
D558_RS15880	COG1286	toxin biosynthetic process
D558_RS15890	COG0285	dihydrofolate synthase activity
D558_RS15900	COG3181	Tripartite tricarboxylate transporter family receptor
D558_RS15925	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
D558_RS15945	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D558_RS15955	COG1677	Flagellar hook-basal body complex protein FliE
D558_RS15965	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D558_RS15970	COG1317	bacterial-type flagellum organization
D558_RS15990	COG1580	Controls the rotational direction of flagella during chemotaxis
D558_RS16000	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D558_RS16025	COG0840	transmembrane signaling receptor activity
D558_RS16050	COG1191	sigma factor activity
D558_RS16060	COG2801	Transposase and inactivated derivatives
D558_RS16065	COG2801	Transposase and inactivated derivatives
D558_RS16100	COG1619	proteins homologs of microcin C7 resistance protein MccF
D558_RS16125	COG1126	abc transporter atp-binding protein
D558_RS16130	COG0765	amino acid transport
D558_RS16135	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D558_RS16195	COG1253	flavin adenine dinucleotide binding
D558_RS16205	COG2197	response regulator
D558_RS16210	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D558_RS16210	COG2205	protein histidine kinase activity
D558_RS16230	COG2801	Transposase and inactivated derivatives
D558_RS16235	COG0076	glutamate decarboxylase activity
D558_RS16240	COG2985	domain, Protein
D558_RS16245	COG3189	MarR family transcriptional regulator
D558_RS16255	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D558_RS16265	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
D558_RS16265	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D558_RS16295	COG0688	phosphatidylethanolamine metabolic process
D558_RS16300	COG1304	FMN binding
D558_RS16305	COG1464	Belongs to the NlpA lipoprotein family
D558_RS16310	COG2801	Transposase and inactivated derivatives
D558_RS16320	COG0697	spore germination
D558_RS16325	COG2133	pyrroloquinoline quinone binding
D558_RS16330	COG0625	glutathione transferase activity
D558_RS16340	COG1794	racemase activity, acting on amino acids and derivatives
D558_RS16360	COG0559	Belongs to the binding-protein-dependent transport system permease family
D558_RS16370	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
D558_RS16385	COG1175	transmembrane transport
D558_RS16390	COG0395	ABC-type sugar transport system, permease component
D558_RS16395	COG3842	ATPase activity
D558_RS16415	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
D558_RS16430	COG0438	transferase activity, transferring glycosyl groups
D558_RS16470	COG0783	Belongs to the Dps family
D558_RS16475	COG0583	DNA-binding transcription factor activity
D558_RS16480	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
D558_RS16505	COG1840	ABC-type Fe3 transport system, periplasmic component
D558_RS16515	COG3842	ATPase activity
D558_RS16520	COG1741	Belongs to the pirin family
D558_RS16530	COG0583	DNA-binding transcription factor activity
D558_RS16545	COG0174	glutamine synthetase
D558_RS16550	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D558_RS16555	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
D558_RS16565	COG0840	transmembrane signaling receptor activity
D558_RS16575	COG0583	DNA-binding transcription factor activity
D558_RS16580	COG1960	acyl-CoA dehydrogenase activity
D558_RS16585	COG2079	MmgE PrpD family protein
D558_RS16595	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
D558_RS16600	COG1561	YicC-like family, N-terminal region
D558_RS16615	COG0791	NLP P60 protein
D558_RS16620	COG1028	Short-chain dehydrogenase reductase Sdr
D558_RS16625	COG0194	GDP metabolic process
D558_RS16630	COG1758	RNA polymerase activity
D558_RS16635	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D558_RS16645	COG0765	amino acid transport
D558_RS16650	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D558_RS16675	COG3121	Chaperone
D558_RS16710	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D558_RS16715	COG0584	glycerophosphoryl diester phosphodiesterase
D558_RS16720	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
D558_RS16740	COG2217	Heavy metal translocating P-type atpase
D558_RS16745	COG0789	Transcriptional regulator
D558_RS16750	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D558_RS16760	COG2801	Transposase and inactivated derivatives
D558_RS16785	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
D558_RS16795	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
D558_RS16820	COG0583	DNA-binding transcription factor activity
D558_RS16825	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
D558_RS16830	COG2252	PERMEase
D558_RS16835	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D558_RS16840	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D558_RS16880	COG1619	proteins homologs of microcin C7 resistance protein MccF
D558_RS16885	COG0590	tRNA wobble adenosine to inosine editing
D558_RS16900	COG1320	monovalent cation:proton antiporter activity
D558_RS16905	COG2212	antiporter activity
D558_RS16910	COG1863	multisubunit Na H antiporter MnhE subunit
D558_RS16915	COG0651	ATP synthesis coupled electron transport
D558_RS16930	COG3181	Tripartite tricarboxylate transporter family receptor
D558_RS16950	COG0420	3'-5' exonuclease activity
D558_RS16980	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D558_RS17000	COG2130	NADP-dependent
D558_RS17005	COG1309	transcriptional regulator
D558_RS17015	COG1131	(ABC) transporter
D558_RS17020	COG0842	Transport permease protein
D558_RS17030	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
D558_RS17065	COG0602	queuosine metabolic process
D558_RS17070	COG0720	synthase
D558_RS17085	COG0840	transmembrane signaling receptor activity
D558_RS17100	COG0587	DNA-directed DNA polymerase activity
D558_RS17110	COG0390	transport system, permease component
D558_RS17115	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D558_RS17120	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
D558_RS17170	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
D558_RS17195	COG5507	3-demethylubiquinone-9 3-methyltransferase
D558_RS17225	COG1396	sequence-specific DNA binding
D558_RS17240	COG2801	Transposase and inactivated derivatives
D558_RS17245	COG2801	Transposase and inactivated derivatives
D558_RS17255	COG0583	DNA-binding transcription factor activity
D558_RS17260	COG2814	Major facilitator Superfamily
D558_RS17285	COG2807	transmembrane transport
D558_RS17290	COG2207	Transcriptional regulator
D558_RS17295	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
D558_RS17300	COG2814	Major facilitator Superfamily
D558_RS17315	COG1012	belongs to the aldehyde dehydrogenase family
D558_RS17350	COG0583	DNA-binding transcription factor activity
D558_RS17370	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D558_RS17395	COG0384	phenazine biosynthesis protein PhzF
D558_RS17400	COG1733	regulation of RNA biosynthetic process
D558_RS17435	COG3177	Filamentation induced by cAMP protein fic
D558_RS17480	COG0601	transmembrane transport
D558_RS17495	COG2801	Transposase and inactivated derivatives
D558_RS17500	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D558_RS17510	COG4608	Belongs to the ABC transporter superfamily
D558_RS17515	COG0747	negative chemotaxis
D558_RS17560	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
D558_RS17565	COG2801	Transposase and inactivated derivatives
D558_RS17575	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D558_RS17575	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
D558_RS17580	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D558_RS17590	COG0613	PHP domain protein
D558_RS17650	COG1012	belongs to the aldehyde dehydrogenase family
D558_RS17660	COG0583	DNA-binding transcription factor activity
D558_RS17680	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D558_RS17690	COG3181	Tripartite tricarboxylate transporter family receptor
D558_RS17695	COG2963	transposase activity
D558_RS17700	COG3181	Tripartite tricarboxylate transporter family receptor
D558_RS17730	COG1595	DNA-templated transcription, initiation
D558_RS17735	COG3712	iron ion homeostasis
D558_RS17750	COG1136	(ABC) transporter
D558_RS17765	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
D558_RS17770	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
D558_RS17775	COG1028	Short-chain dehydrogenase reductase Sdr
D558_RS17780	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
D558_RS17790	COG1803	Methylglyoxal synthase
D558_RS17810	COG2801	Transposase and inactivated derivatives
D558_RS17825	COG2963	transposase activity
D558_RS17835	COG2975	iron-sulfur cluster assembly
D558_RS17840	COG0633	Ferredoxin
D558_RS17845	COG0443	Heat shock 70 kDa protein
D558_RS17850	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
D558_RS17855	COG0316	Belongs to the HesB IscA family
D558_RS17860	COG0822	iron-sulfur transferase activity
D558_RS17865	COG1104	cysteine desulfurase activity
D558_RS17875	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D558_RS17880	COG0556	nucleotide-excision repair
D558_RS17890	COG2801	Transposase and inactivated derivatives
D558_RS17915	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D558_RS17935	COG2801	Transposase and inactivated derivatives
D558_RS17950	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D558_RS17960	COG0740	serine-type endopeptidase activity
D558_RS17965	COG0544	peptidyl-prolyl cis-trans isomerase activity
D558_RS17995	COG2801	Transposase and inactivated derivatives
D558_RS18005	COG1278	Cold shock
D558_RS18035	COG2433	Pfam Transposase IS66
D558_RS18050	COG2801	Transposase and inactivated derivatives
D558_RS18090	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D558_RS18125	COG2801	Transposase and inactivated derivatives
D558_RS18140	COG2200	EAL domain
D558_RS18175	COG0477	Major facilitator Superfamily
D558_RS18235	COG2200	EAL domain