locus-tag	class	description
D560_RS00030	COG2801	Transposase and inactivated derivatives
D560_RS00035	COG1530	ribonuclease E activity
D560_RS00045	COG2801	Transposase and inactivated derivatives
D560_RS00075	COG1566	PFAM secretion protein HlyD family protein
D560_RS00080	COG2814	Major facilitator Superfamily
D560_RS00085	COG0473	3-isopropylmalate dehydrogenase activity
D560_RS00105	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D560_RS00110	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D560_RS00115	COG0433	COG0433 Predicted ATPase
D560_RS00120	COG0217	transcriptional regulatory protein
D560_RS00140	COG0799	negative regulation of ribosome biogenesis
D560_RS00145	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
D560_RS00150	COG0424	maF-like protein
D560_RS00160	COG4191	Histidine kinase
D560_RS00165	COG2204	response regulator
D560_RS00190	COG0500	methyltransferase
D560_RS00205	COG0803	Belongs to the bacterial solute-binding protein 9 family
D560_RS00210	COG1121	(ABC) transporter
D560_RS00215	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D560_RS00220	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D560_RS00235	COG2801	Transposase and inactivated derivatives
D560_RS00240	COG2801	Transposase and inactivated derivatives
D560_RS00255	COG4993	Dehydrogenase
D560_RS00265	COG4772	TonB-dependent receptor
D560_RS00270	COG2814	Major facilitator Superfamily
D560_RS00290	COG0037	tRNA processing
D560_RS00295	COG0825	malonyl-CoA metabolic process
D560_RS00305	COG0215	cysteine-tRNA ligase activity
D560_RS00315	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D560_RS00320	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D560_RS00325	COG1968	undecaprenyl-diphosphatase activity
D560_RS00330	COG1253	flavin adenine dinucleotide binding
D560_RS00335	COG0483	inositol monophosphate 1-phosphatase activity
D560_RS00355	COG0668	transmembrane transport
D560_RS00380	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D560_RS00390	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
D560_RS00405	COG1802	Transcriptional regulator
D560_RS00425	COG3360	Dodecin
D560_RS00445	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
D560_RS00450	COG2850	peptidyl-arginine hydroxylation
D560_RS00460	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
D560_RS00465	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D560_RS00470	COG1994	Peptidase M50
D560_RS00480	COG2321	neutral zinc metallopeptidase
D560_RS00500	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D560_RS00510	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D560_RS00515	COG2271	Major facilitator Superfamily
D560_RS00540	COG2801	Transposase and inactivated derivatives
D560_RS00545	COG2963	transposase activity
D560_RS00600	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
D560_RS00620	COG1960	acyl-CoA dehydrogenase activity
D560_RS00630	COG2186	Transcriptional regulator
D560_RS00655	COG1595	DNA-templated transcription, initiation
D560_RS00675	COG2801	Transposase and inactivated derivatives
D560_RS00690	COG1028	Short-chain dehydrogenase reductase Sdr
D560_RS00700	COG0179	Fumarylacetoacetate (FAA) hydrolase
D560_RS00720	COG4604	ABC transporter, ATP-binding protein
D560_RS00725	COG4605	iron ion homeostasis
D560_RS00730	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D560_RS00735	COG4607	ABC-type enterochelin transport system periplasmic component
D560_RS00740	COG0438	transferase activity, transferring glycosyl groups
D560_RS00750	COG0149	triose-phosphate isomerase activity
D560_RS00755	COG4221	oxidoreductase activity
D560_RS00755	COG3321	synthase
D560_RS00755	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D560_RS00755	COG0604	alcohol dehydrogenase
D560_RS00785	COG0668	transmembrane transport
D560_RS00790	COG0165	Argininosuccinate lyase
D560_RS00800	COG0789	Transcriptional regulator
D560_RS00810	COG0501	Belongs to the peptidase M48B family
D560_RS00815	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D560_RS00845	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D560_RS00850	COG0154	amidase activity
D560_RS00865	COG3468	outer membrane autotransporter barrel domain protein
D560_RS00870	COG2801	Transposase and inactivated derivatives
D560_RS00875	COG2801	Transposase and inactivated derivatives
D560_RS00905	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
D560_RS00910	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
D560_RS00915	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
D560_RS00920	COG1674	ftsk spoiiie
D560_RS00925	COG0492	ferredoxin-NADP+ reductase activity
D560_RS00930	COG1193	negative regulation of DNA recombination
D560_RS00945	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D560_RS00955	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
D560_RS00965	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
D560_RS00975	COG0745	RESPONSE REGULATOR receiver
D560_RS01010	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D560_RS01030	COG0612	Peptidase, M16
D560_RS01040	COG0443	Heat shock 70 kDa protein
D560_RS01050	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
D560_RS01060	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
D560_RS01065	COG1420	regulation of RNA biosynthetic process
D560_RS01070	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
D560_RS01075	COG0497	DNA recombination
D560_RS01085	COG2801	Transposase and inactivated derivatives
D560_RS01100	COG0735	belongs to the Fur family
D560_RS01105	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D560_RS01125	COG2801	Transposase and inactivated derivatives
D560_RS01135	COG2801	Transposase and inactivated derivatives
D560_RS01155	COG2828	Protein conserved in bacteria
D560_RS01160	COG1280	lysine exporter protein (LysE YggA)
D560_RS01165	COG3181	Tripartite tricarboxylate transporter family receptor
D560_RS01180	COG1028	Short-chain dehydrogenase reductase Sdr
D560_RS01185	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
D560_RS01195	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
D560_RS01200	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D560_RS01205	COG1335	isochorismatase
D560_RS01210	COG0523	cobalamin synthesis protein
D560_RS01240	COG0583	DNA-binding transcription factor activity
D560_RS01250	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
D560_RS01255	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
D560_RS01260	COG0167	dihydroorotate dehydrogenase activity
D560_RS01275	COG2801	Transposase and inactivated derivatives
D560_RS01300	COG1414	Transcriptional regulator
D560_RS01320	COG0513	Belongs to the DEAD box helicase family
D560_RS01370	COG2801	Transposase and inactivated derivatives
D560_RS01385	COG0006	proline dipeptidase activity
D560_RS01395	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D560_RS01420	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
D560_RS01425	COG0632	four-way junction helicase activity
D560_RS01440	COG2255	four-way junction helicase activity
D560_RS01445	COG0514	ATP-dependent DNA helicase (RecQ)
D560_RS01465	COG1294	oxidase, subunit
D560_RS01475	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D560_RS01480	COG0850	regulation of cytokinetic process
D560_RS01485	COG2894	cell division
D560_RS01510	COG0488	(ABC) transporter
D560_RS01525	COG4608	Belongs to the ABC transporter superfamily
D560_RS01530	COG0444	Belongs to the ABC transporter superfamily
D560_RS01550	COG1215	transferase activity, transferring glycosyl groups
D560_RS01555	COG0583	DNA-binding transcription factor activity
D560_RS01565	COG1686	Belongs to the peptidase S11 family
D560_RS01585	COG1064	alcohol dehydrogenase
D560_RS01590	COG4191	Histidine kinase
D560_RS01595	COG4566	intracellular signal transduction
D560_RS01605	COG1802	Transcriptional regulator
D560_RS01630	COG3181	Tripartite tricarboxylate transporter family receptor
D560_RS01635	COG0513	Belongs to the DEAD box helicase family
D560_RS01640	COG0668	transmembrane transport
D560_RS01655	COG1595	DNA-templated transcription, initiation
D560_RS01700	COG0531	amino acid
D560_RS01705	COG1982	Orn Lys Arg decarboxylase major
D560_RS01725	COG2801	Transposase and inactivated derivatives
D560_RS01730	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
D560_RS01735	COG0459	protein refolding
D560_RS01745	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
D560_RS01750	COG1252	NADH dehydrogenase
D560_RS01755	COG0284	orotidine-5'-phosphate decarboxylase activity
D560_RS01765	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
D560_RS01775	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D560_RS01780	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
D560_RS01810	COG1595	DNA-templated transcription, initiation
D560_RS01820	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
D560_RS01825	COG3639	organic phosphonate transmembrane transporter activity
D560_RS01830	COG3639	organic phosphonate transmembrane transporter activity
D560_RS01845	COG0742	ribosomal rna small subunit methyltransferase
D560_RS01850	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
D560_RS01855	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
D560_RS01860	COG3135	benzoate transporter
D560_RS01880	COG4774	siderophore transport
D560_RS01900	COG1024	Enoyl-CoA hydratase
D560_RS01905	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D560_RS01910	COG1960	acyl-CoA dehydrogenase activity
D560_RS01920	COG0318	PFAM AMP-dependent synthetase and ligase
D560_RS01925	COG3181	Tripartite tricarboxylate transporter family receptor
D560_RS01935	COG0583	DNA-binding transcription factor activity
D560_RS01960	COG0277	FAD linked oxidase domain protein
D560_RS01980	COG1802	Transcriptional regulator
D560_RS01990	COG2271	Major facilitator Superfamily
D560_RS02000	COG0583	DNA-binding transcription factor activity
D560_RS02005	COG4774	siderophore transport
D560_RS02025	COG0012	GTP binding
D560_RS02035	COG0193	aminoacyl-tRNA hydrolase activity
D560_RS02040	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
D560_RS02045	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D560_RS02055	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
D560_RS02070	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
D560_RS02080	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D560_RS02100	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
D560_RS02115	COG2186	Transcriptional regulator
D560_RS02125	COG3181	Tripartite tricarboxylate transporter family receptor
D560_RS02140	COG0277	FAD linked oxidase domain protein
D560_RS02160	COG0438	transferase activity, transferring glycosyl groups
D560_RS02165	COG0438	transferase activity, transferring glycosyl groups
D560_RS02195	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
D560_RS02200	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D560_RS02210	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
D560_RS02220	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
D560_RS02230	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D560_RS02235	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D560_RS02250	COG0747	negative chemotaxis
D560_RS02260	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D560_RS02285	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D560_RS02285	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D560_RS02290	COG0509	glycine decarboxylation via glycine cleavage system
D560_RS02300	COG2081	HI0933 family
D560_RS02315	COG0456	acetyltransferase
D560_RS02320	COG0717	Belongs to the dCTP deaminase family
D560_RS02335	COG0489	protein tyrosine kinase activity
D560_RS02345	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D560_RS02345	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D560_RS02370	COG3539	Fimbrial protein
D560_RS02385	COG0745	RESPONSE REGULATOR receiver
D560_RS02405	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D560_RS02410	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
D560_RS02425	COG2084	Dehydrogenase
D560_RS02430	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D560_RS02455	COG3842	ATPase activity
D560_RS02460	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
D560_RS02465	COG1960	acyl-CoA dehydrogenase activity
D560_RS02475	COG0583	DNA-binding transcription factor activity
D560_RS02485	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D560_RS02490	COG1024	Enoyl-CoA hydratase
D560_RS02505	COG0583	DNA-binding transcription factor activity
D560_RS02515	COG0625	glutathione transferase activity
D560_RS02555	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D560_RS02560	COG0583	DNA-binding transcription factor activity
D560_RS02570	COG1024	Enoyl-CoA hydratase
D560_RS02585	COG1028	Short-chain dehydrogenase reductase Sdr
D560_RS02590	COG1028	Short-chain dehydrogenase reductase Sdr
D560_RS02605	COG3181	Tripartite tricarboxylate transporter family receptor
D560_RS02610	COG1028	Short-chain dehydrogenase reductase Sdr
D560_RS02620	COG3181	Tripartite tricarboxylate transporter family receptor
D560_RS02660	COG0583	DNA-binding transcription factor activity
D560_RS02665	COG1960	acyl-CoA dehydrogenase activity
D560_RS02670	COG3181	Tripartite tricarboxylate transporter family receptor
D560_RS02700	COG2801	Transposase and inactivated derivatives
D560_RS02705	COG0560	Phosphoserine phosphatase
D560_RS02710	COG0583	DNA-binding transcription factor activity
D560_RS02720	COG3842	ATPase activity
D560_RS02735	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
D560_RS02755	COG0625	glutathione transferase activity
D560_RS02800	COG4336	lyase activity
D560_RS02810	COG0326	Molecular chaperone. Has ATPase activity
D560_RS02815	COG2233	PERMEase
D560_RS02835	COG2801	Transposase and inactivated derivatives
D560_RS02850	COG2982	Protein involved in outer membrane biogenesis
D560_RS02855	COG2982	Protein involved in outer membrane biogenesis
D560_RS02860	COG2818	Glycosylase
D560_RS02890	COG0402	S-adenosylhomocysteine deaminase activity
D560_RS02900	COG0156	8-amino-7-oxononanoate synthase activity
D560_RS02905	COG2877	3-deoxy-8-phosphooctulonate synthase activity
D560_RS02930	COG2801	Transposase and inactivated derivatives
D560_RS02960	COG1464	Belongs to the NlpA lipoprotein family
D560_RS02965	COG2011	ABC-type metal ion transport system permease component
D560_RS02970	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D560_RS02975	COG1501	Belongs to the glycosyl hydrolase 31 family
D560_RS02985	COG0483	inositol monophosphate 1-phosphatase activity
D560_RS02990	COG0318	PFAM AMP-dependent synthetase and ligase
D560_RS02995	COG1473	amidohydrolase
D560_RS03000	COG0583	DNA-binding transcription factor activity
D560_RS03005	COG2855	membrane
D560_RS03015	COG2239	Acts as a magnesium transporter
D560_RS03030	COG1522	sequence-specific DNA binding
D560_RS03050	COG2801	Transposase and inactivated derivatives
D560_RS03070	COG0330	HflC and HflK could
D560_RS03075	COG0330	HflC and HflK could
D560_RS03080	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D560_RS03085	COG1923	regulation of RNA biosynthetic process
D560_RS03095	COG1160	GTP binding
D560_RS03100	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D560_RS03105	COG2976	Protein conserved in bacteria
D560_RS03110	COG0124	histidyl-tRNA synthetase
D560_RS03125	COG0820	rRNA (adenine-C2-)-methyltransferase activity
D560_RS03130	COG0105	UTP biosynthetic process
D560_RS03135	COG0525	valine-tRNA ligase activity
D560_RS03145	COG0336	Belongs to the RNA methyltransferase TrmD family
D560_RS03150	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
D560_RS03155	COG0228	four-way junction DNA binding
D560_RS03160	COG0425	Belongs to the sulfur carrier protein TusA family
D560_RS03215	COG2801	Transposase and inactivated derivatives
D560_RS03235	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D560_RS03235	COG0543	2 iron, 2 sulfur cluster binding
D560_RS03240	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
D560_RS03245	COG2076	Multidrug Resistance protein
D560_RS03250	COG0633	Ferredoxin
D560_RS03250	COG3217	Mosc domain protein beta barrel domain protein
D560_RS03255	COG5285	phytanoyl-CoA dioxygenase
D560_RS03260	COG0662	Cupin 2, conserved barrel domain protein
D560_RS03285	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D560_RS03315	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
D560_RS03325	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
D560_RS03330	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
D560_RS03335	COG1760	l-serine dehydratase
D560_RS03340	COG1283	sodium-dependent phosphate transmembrane transporter activity
D560_RS03345	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D560_RS03350	COG0412	Dienelactone hydrolase
D560_RS03355	COG0428	transporter
D560_RS03365	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
D560_RS03370	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D560_RS03375	COG1845	cytochrome c oxidase, subunit III
D560_RS03380	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
D560_RS03390	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D560_RS03390	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D560_RS03415	COG1942	4-Oxalocrotonate Tautomerase
D560_RS03425	COG4176	ABC-type proline glycine betaine transport system permease component
D560_RS03440	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
D560_RS03445	COG2814	Major facilitator Superfamily
D560_RS03450	COG0227	Belongs to the bacterial ribosomal protein bL28 family
D560_RS03455	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D560_RS03480	COG1846	Transcriptional regulator
D560_RS03485	COG2814	Major facilitator Superfamily
D560_RS03490	COG0495	leucyl-tRNA aminoacylation
D560_RS03505	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
D560_RS03525	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D560_RS03530	COG2274	protein secretion by the type I secretion system
D560_RS03545	COG2801	Transposase and inactivated derivatives
D560_RS03575	COG0427	acetyl-CoA hydrolase
D560_RS03585	COG3264	Mechanosensitive ion channel
D560_RS03585	COG1511	domain protein
D560_RS03590	COG0730	response to heat
D560_RS03605	COG2176	DNA-directed DNA polymerase activity
D560_RS03630	COG3384	dioxygenase
D560_RS03645	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
D560_RS03670	COG2801	Transposase and inactivated derivatives
D560_RS03755	COG1846	Transcriptional regulator
D560_RS03790	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
D560_RS03800	COG2070	2-Nitropropane dioxygenase
D560_RS03805	COG2070	2-Nitropropane dioxygenase
D560_RS03815	COG2610	gluconate transmembrane transporter activity
D560_RS03830	COG1408	metallophosphoesterase
D560_RS03840	COG2199	diguanylate cyclase activity
D560_RS03845	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
D560_RS03890	COG0583	DNA-binding transcription factor activity
D560_RS03905	COG1024	Enoyl-CoA hydratase
D560_RS03910	COG2186	Transcriptional regulator
D560_RS03915	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D560_RS03925	COG0833	amino acid
D560_RS03930	COG2894	cell division
D560_RS03935	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
D560_RS03960	COG5265	(ABC) transporter
D560_RS04005	COG1971	Probably functions as a manganese efflux pump
D560_RS04010	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D560_RS04025	COG2814	Major facilitator Superfamily
D560_RS04050	COG4608	Belongs to the ABC transporter superfamily
D560_RS04070	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D560_RS04080	COG3383	formate dehydrogenase (NAD+) activity
D560_RS04095	COG0747	negative chemotaxis
D560_RS04110	COG0625	glutathione transferase activity
D560_RS04140	COG1595	DNA-templated transcription, initiation
D560_RS04150	COG4774	siderophore transport
D560_RS04165	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D560_RS04180	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
D560_RS04185	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
D560_RS04210	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D560_RS04215	COG1024	Enoyl-CoA hydratase
D560_RS04250	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D560_RS04255	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D560_RS04260	COG1116	anion transmembrane transporter activity
D560_RS04265	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D560_RS04270	COG3585	molybdate ion transport
D560_RS04325	COG0583	DNA-binding transcription factor activity
D560_RS04330	COG4948	Mandelate Racemase Muconate Lactonizing
D560_RS04335	COG3181	Tripartite tricarboxylate transporter family receptor
D560_RS04365	COG3181	Tripartite tricarboxylate transporter family receptor
D560_RS04400	COG4177	L-phenylalanine transmembrane transporter activity
D560_RS04425	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D560_RS04440	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
D560_RS04445	COG1538	Outer membrane efflux protein
D560_RS04450	COG0577	efflux transmembrane transporter activity
D560_RS04450	COG1136	(ABC) transporter
D560_RS04455	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D560_RS04470	COG0259	pyridoxamine-phosphate oxidase activity
D560_RS04475	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D560_RS04480	COG0579	oxidoreductase
D560_RS04490	COG0405	Gamma-glutamyltransferase
D560_RS04500	COG3181	Tripartite tricarboxylate transporter family receptor
D560_RS04510	COG0114	fumarate hydratase activity
D560_RS04515	COG0802	atpase or kinase
D560_RS04520	COG0860	N-Acetylmuramoyl-L-alanine amidase
D560_RS04525	COG0586	Pfam SNARE associated Golgi protein
D560_RS04530	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
D560_RS04535	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
D560_RS04540	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
D560_RS04555	COG0617	tRNA 3'-terminal CCA addition
D560_RS04575	COG2801	Transposase and inactivated derivatives
D560_RS04595	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
D560_RS04605	COG1024	Enoyl-CoA hydratase
D560_RS04615	COG2188	Transcriptional regulator
D560_RS04635	COG0752	glycyl-tRNA synthetase alpha subunit
D560_RS04640	COG0751	glycine-tRNA ligase activity
D560_RS04645	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
D560_RS04650	COG0204	Acyl-transferase
D560_RS04680	COG0242	peptide deformylase activity
D560_RS04690	COG0700	Nucleoside recognition
D560_RS04695	COG0469	pyruvate kinase activity
D560_RS04700	COG1929	Belongs to the glycerate kinase type-1 family
D560_RS04705	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
D560_RS04715	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
D560_RS04725	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
D560_RS04735	COG2154	pterin-4-alpha-carbinolamine dehydratase
D560_RS04740	COG2885	chlorophyll binding
D560_RS04750	COG0667	Aldo Keto reductase
D560_RS04760	COG3181	Tripartite tricarboxylate transporter family receptor
D560_RS04765	COG2801	Transposase and inactivated derivatives
D560_RS04780	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D560_RS04785	COG0288	reversible hydration of carbon dioxide
D560_RS04815	COG4829	muconolactone delta-isomerase
D560_RS04820	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
D560_RS04825	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
D560_RS04830	COG1414	Transcriptional regulator
D560_RS04835	COG1028	Short-chain dehydrogenase reductase Sdr
D560_RS04840	COG2031	fatty acid transporter
D560_RS04845	COG1250	3-hydroxyacyl-CoA dehydrogenase
D560_RS04855	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
D560_RS04860	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
D560_RS04875	COG0129	dihydroxy-acid dehydratase activity
D560_RS04880	COG1609	Transcriptional regulator
D560_RS04900	COG4106	trans-aconitate 2-methyltransferase activity
D560_RS04915	COG0820	rRNA (adenine-C2-)-methyltransferase activity
D560_RS04950	COG2801	Transposase and inactivated derivatives
D560_RS04960	COG0163	prenyltransferase activity
D560_RS04965	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
D560_RS04970	COG2890	protein-(glutamine-N5) methyltransferase activity
D560_RS04975	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
D560_RS04980	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
D560_RS05025	COG0659	secondary active sulfate transmembrane transporter activity
D560_RS05045	COG1028	Short-chain dehydrogenase reductase Sdr
D560_RS05065	COG1595	DNA-templated transcription, initiation
D560_RS05080	COG0142	geranyltranstransferase activity
D560_RS05085	COG0261	This protein binds to 23S rRNA in the presence of protein L20
D560_RS05090	COG0211	Belongs to the bacterial ribosomal protein bL27 family
D560_RS05095	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
D560_RS05100	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
D560_RS05120	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D560_RS05120	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D560_RS05125	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
D560_RS05135	COG0583	DNA-binding transcription factor activity
D560_RS05140	COG0861	Integral membrane protein TerC family
D560_RS05155	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D560_RS05160	COG0793	Belongs to the peptidase S41A family
D560_RS05165	COG4942	peptidase
D560_RS05170	COG0588	phosphoglycerate mutase activity
D560_RS05180	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D560_RS05185	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
D560_RS05190	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
D560_RS05195	COG3181	Tripartite tricarboxylate transporter family receptor
D560_RS05210	COG2226	methyltransferase
D560_RS05215	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
D560_RS05220	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D560_RS05230	COG2204	response regulator
D560_RS05235	COG5000	phosphorelay sensor kinase activity
D560_RS05245	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
D560_RS05245	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D560_RS05280	COG2188	Transcriptional regulator
D560_RS05295	COG0583	DNA-binding transcription factor activity
D560_RS05300	COG1012	belongs to the aldehyde dehydrogenase family
D560_RS05320	COG0546	phosphoglycolate phosphatase activity
D560_RS05340	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
D560_RS05345	COG0242	peptide deformylase activity
D560_RS05355	COG1522	sequence-specific DNA binding
D560_RS05360	COG2879	small protein
D560_RS05395	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D560_RS05400	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D560_RS05410	COG3181	Tripartite tricarboxylate transporter family receptor
D560_RS05475	COG1172	Belongs to the binding-protein-dependent transport system permease family
D560_RS05510	COG0640	Transcriptional regulator
D560_RS05550	COG0735	belongs to the Fur family
D560_RS05555	COG2207	Transcriptional regulator
D560_RS05560	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
D560_RS05565	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
D560_RS05570	COG0513	Belongs to the DEAD box helicase family
D560_RS05595	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
D560_RS05610	COG1305	Transglutaminase-like
D560_RS05650	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
D560_RS05655	COG1950	PFAM Membrane protein of
D560_RS05680	COG0024	Methionine aminopeptidase
D560_RS05685	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
D560_RS05695	COG1560	Kdo2-lipid A biosynthetic process
D560_RS05700	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
D560_RS05710	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
D560_RS05745	COG0735	belongs to the Fur family
D560_RS05750	COG0523	cobalamin synthesis protein
D560_RS05765	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
D560_RS05775	COG2096	Adenosyltransferase
D560_RS05780	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
D560_RS05785	COG0321	lipoyl(octanoyl) transferase activity
D560_RS05795	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D560_RS05800	COG1686	Belongs to the peptidase S11 family
D560_RS05825	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D560_RS05835	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
D560_RS05845	COG0859	PFAM glycosyl transferase family 9
D560_RS05880	COG0477	Major facilitator Superfamily
D560_RS05895	COG3568	Endonuclease Exonuclease Phosphatase
D560_RS05900	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
D560_RS05930	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D560_RS05935	COG1956	GAF domain-containing protein
D560_RS05940	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D560_RS05955	COG2186	Transcriptional regulator
D560_RS05960	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
D560_RS06020	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D560_RS06025	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
D560_RS06030	COG1086	Polysaccharide biosynthesis protein
D560_RS06060	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
D560_RS06070	COG1028	Short-chain dehydrogenase reductase Sdr
D560_RS06075	COG1012	belongs to the aldehyde dehydrogenase family
D560_RS06080	COG2801	Transposase and inactivated derivatives
D560_RS06100	COG1522	sequence-specific DNA binding
D560_RS06105	COG3781	membrane
D560_RS06125	COG2801	Transposase and inactivated derivatives
D560_RS06130	COG2801	Transposase and inactivated derivatives
D560_RS06150	COG0592	DNA-directed DNA polymerase activity
D560_RS06155	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
D560_RS06160	COG0230	Belongs to the bacterial ribosomal protein bL34 family
D560_RS06165	COG0594	ribonuclease P activity
D560_RS06170	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
D560_RS06175	COG0706	membrane insertase activity
D560_RS06180	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
D560_RS06185	COG1473	amidohydrolase
D560_RS06190	COG4608	Belongs to the ABC transporter superfamily
D560_RS06195	COG0444	Belongs to the ABC transporter superfamily
D560_RS06200	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D560_RS06205	COG0601	transmembrane transport
D560_RS06215	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
D560_RS06220	COG1505	serine-type exopeptidase activity
D560_RS06260	COG0436	Aminotransferase
D560_RS06265	COG1278	Cold shock
D560_RS06275	COG0357	Ribosomal RNA small subunit methyltransferase G
D560_RS06280	COG1192	Involved in chromosome partitioning
D560_RS06290	COG0252	asparaginase activity
D560_RS06310	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D560_RS06320	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D560_RS06330	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
D560_RS06335	COG0081	regulation of translation
D560_RS06340	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
D560_RS06345	COG0222	ribosome binding
D560_RS06350	COG0085	RNA polymerase activity
D560_RS06355	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
D560_RS06390	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
D560_RS06395	COG0049	tRNA binding
D560_RS06400	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D560_RS06405	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D560_RS06410	COG0051	transcription antitermination factor activity, RNA binding
D560_RS06415	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
D560_RS06420	COG0088	Forms part of the polypeptide exit tunnel
D560_RS06425	COG0089	rRNA binding
D560_RS06430	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
D560_RS06435	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
D560_RS06440	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
D560_RS06445	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
D560_RS06450	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
D560_RS06455	COG0255	Belongs to the universal ribosomal protein uL29 family
D560_RS06460	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
D560_RS06470	COG4177	L-phenylalanine transmembrane transporter activity
D560_RS06485	COG0411	ABC transporter
D560_RS06515	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
D560_RS06520	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
D560_RS06530	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
D560_RS06535	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
D560_RS06540	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
D560_RS06545	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
D560_RS06550	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
D560_RS06555	COG1841	ribosomal large subunit assembly
D560_RS06560	COG0200	Binds to the 23S rRNA
D560_RS06565	COG0201	protein transport
D560_RS06570	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
D560_RS06575	COG0257	Belongs to the bacterial ribosomal protein bL36 family
D560_RS06580	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
D560_RS06585	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
D560_RS06590	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
D560_RS06595	COG0202	RNA polymerase activity
D560_RS06600	COG0203	ribosomal protein L17
D560_RS06605	COG0537	adenosine 5'-monophosphoramidase activity
D560_RS06610	COG1324	tolerance protein
D560_RS06615	COG4232	protein-disulfide reductase activity
D560_RS06630	COG0218	Necessary for normal cell division and for the maintenance of normal septation
D560_RS06645	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D560_RS06655	COG1965	Belongs to the frataxin family
D560_RS06665	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
D560_RS06670	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
D560_RS06675	COG0232	Belongs to the dGTPase family. Type 2 subfamily
D560_RS06695	COG2814	Major facilitator Superfamily
D560_RS06710	COG2801	Transposase and inactivated derivatives
D560_RS06755	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D560_RS06760	COG2922	Belongs to the Smg family
D560_RS06765	COG1629	transport
D560_RS06775	COG2358	TRAP transporter, solute receptor (TAXI family
D560_RS06785	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D560_RS06800	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D560_RS06805	COG0183	Belongs to the thiolase family
D560_RS06810	COG1960	acyl-CoA dehydrogenase activity
D560_RS06835	COG2200	EAL domain
D560_RS06840	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D560_RS06850	COG0018	arginyl-trna synthetase
D560_RS06865	COG0154	amidase activity
D560_RS06870	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D560_RS06880	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
D560_RS06890	COG0697	spore germination
D560_RS06920	COG2151	metal-sulfur cluster biosynthetic enzyme
D560_RS06955	COG3350	monooxygenase activity
D560_RS06985	COG1309	transcriptional regulator
D560_RS07015	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
D560_RS07020	COG1280	lysine exporter protein (LysE YggA)
D560_RS07025	COG0513	Belongs to the DEAD box helicase family
D560_RS07035	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
D560_RS07040	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
D560_RS07070	COG2969	positive regulation of protein catabolic process
D560_RS07075	COG0625	glutathione transferase activity
D560_RS07080	COG2857	Cytochrome c1
D560_RS07085	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
D560_RS07090	COG0723	plastoquinol--plastocyanin reductase activity
D560_RS07095	COG1970	mechanosensitive ion channel activity
D560_RS07100	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
D560_RS07105	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D560_RS07120	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D560_RS07130	COG0140	phosphoribosyl-ATP diphosphatase activity
D560_RS07135	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
D560_RS07140	COG0107	imidazoleglycerol-phosphate synthase activity
D560_RS07145	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
D560_RS07155	COG0131	Imidazoleglycerol-phosphate dehydratase
D560_RS07160	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D560_RS07165	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
D560_RS07170	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
D560_RS07175	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D560_RS07185	COG0842	Transport permease protein
D560_RS07190	COG1131	(ABC) transporter
D560_RS07210	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D560_RS07235	COG0069	glutamate synthase activity
D560_RS07235	COG0067	glutamate synthase
D560_RS07235	COG0070	glutamate synthase
D560_RS07255	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
D560_RS07275	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D560_RS07280	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
D560_RS07300	COG2801	Transposase and inactivated derivatives
D560_RS07315	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D560_RS07350	COG0109	protoheme IX farnesyltransferase activity
D560_RS07355	COG1999	signal sequence binding
D560_RS07395	COG1522	sequence-specific DNA binding
D560_RS07445	COG4948	Mandelate Racemase Muconate Lactonizing
D560_RS07460	COG3119	arylsulfatase activity
D560_RS07480	COG2801	Transposase and inactivated derivatives
D560_RS07485	COG1079	Belongs to the binding-protein-dependent transport system permease family
D560_RS07500	COG0402	S-adenosylhomocysteine deaminase activity
D560_RS07510	COG1304	FMN binding
D560_RS07515	COG1254	Belongs to the acylphosphatase family
D560_RS07525	COG3181	Tripartite tricarboxylate transporter family receptor
D560_RS07535	COG1414	Transcriptional regulator
D560_RS07545	COG2801	Transposase and inactivated derivatives
D560_RS07555	COG0028	Belongs to the TPP enzyme family
D560_RS07560	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
D560_RS07565	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D560_RS07570	COG1960	acyl-CoA dehydrogenase activity
D560_RS07605	COG3181	Tripartite tricarboxylate transporter family receptor
D560_RS07610	COG0583	DNA-binding transcription factor activity
D560_RS07625	COG0129	dihydroxy-acid dehydratase activity
D560_RS07630	COG2084	Dehydrogenase
D560_RS07645	COG1671	Belongs to the UPF0178 family
D560_RS07650	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
D560_RS07665	COG0443	Heat shock 70 kDa protein
D560_RS07685	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D560_RS07685	COG2169	Transcriptional regulator
D560_RS07700	COG1683	Conserved Protein
D560_RS07705	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D560_RS07720	COG1120	ATPase activity
D560_RS07725	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D560_RS07730	COG4558	Periplasmic binding protein
D560_RS07735	COG3720	iron ion transport
D560_RS07745	COG3712	iron ion homeostasis
D560_RS07750	COG1595	DNA-templated transcription, initiation
D560_RS07770	COG1607	acyl-coa hydrolase
D560_RS07780	COG3383	formate dehydrogenase (NAD+) activity
D560_RS07780	COG0243	molybdopterin cofactor binding
D560_RS07785	COG0243	molybdopterin cofactor binding
D560_RS07785	COG3383	formate dehydrogenase (NAD+) activity
D560_RS07790	COG0437	4 iron, 4 sulfur cluster binding
D560_RS07795	COG2864	formate dehydrogenase
D560_RS07810	COG3276	selenocysteine insertion sequence binding
D560_RS07850	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
D560_RS07855	COG0512	Glutamine amidotransferase of anthranilate synthase
D560_RS07865	COG0546	phosphoglycolate phosphatase activity
D560_RS07870	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
D560_RS07875	COG2967	ApaG domain
D560_RS07880	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
D560_RS07885	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D560_RS07890	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D560_RS07895	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D560_RS07900	COG0037	tRNA processing
D560_RS07920	COG1024	Enoyl-CoA hydratase
D560_RS07935	COG0356	it plays a direct role in the translocation of protons across the membrane
D560_RS07945	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D560_RS07950	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D560_RS07955	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
D560_RS07960	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
D560_RS07965	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
D560_RS07970	COG0355	proton-transporting ATP synthase activity, rotational mechanism
D560_RS07995	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
D560_RS08000	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
D560_RS08005	COG0210	DNA helicase
D560_RS08020	COG4608	Belongs to the ABC transporter superfamily
D560_RS08025	COG0444	Belongs to the ABC transporter superfamily
D560_RS08030	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D560_RS08055	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
D560_RS08060	COG1024	Enoyl-CoA hydratase
D560_RS08065	COG1024	Enoyl-CoA hydratase
D560_RS08070	COG2070	2-Nitropropane dioxygenase
D560_RS08085	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D560_RS08090	COG1250	3-hydroxyacyl-CoA dehydrogenase
D560_RS08110	COG2267	carboxylic ester hydrolase activity
D560_RS08130	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
D560_RS08135	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D560_RS08140	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D560_RS08140	COG2813	Specifically methylates the guanine in position
D560_RS08145	COG2223	nitrite transmembrane transporter activity
D560_RS08150	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
D560_RS08165	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D560_RS08170	COG0708	Exodeoxyribonuclease III
D560_RS08175	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
D560_RS08180	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D560_RS08185	COG0154	amidase activity
D560_RS08190	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D560_RS08195	COG1077	Cell shape determining protein MreB Mrl
D560_RS08200	COG1792	Involved in formation and maintenance of cell shape
D560_RS08210	COG0768	penicillin binding
D560_RS08215	COG0772	Belongs to the SEDS family
D560_RS08220	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
D560_RS08225	COG0471	metal ion transport
D560_RS08230	COG1309	transcriptional regulator
D560_RS08240	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
D560_RS08255	COG2823	Periplasmic or secreted lipoprotein
D560_RS08260	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
D560_RS08265	COG0792	nuclease activity
D560_RS08285	COG1660	Displays ATPase and GTPase activities
D560_RS08300	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
D560_RS08310	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
D560_RS08320	COG3181	Tripartite tricarboxylate transporter family receptor
D560_RS08330	COG1137	ATPase activity
D560_RS08355	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
D560_RS08375	COG1294	oxidase, subunit
D560_RS08395	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D560_RS08410	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D560_RS08435	COG1984	allophanate hydrolase subunit 2
D560_RS08440	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
D560_RS08450	COG0583	DNA-binding transcription factor activity
D560_RS08455	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D560_RS08460	COG5002	protein histidine kinase activity
D560_RS08465	COG0745	RESPONSE REGULATOR receiver
D560_RS08470	COG2226	methyltransferase
D560_RS08505	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D560_RS08515	COG1028	Short-chain dehydrogenase reductase Sdr
D560_RS08535	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
D560_RS08550	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
D560_RS08560	COG2801	Transposase and inactivated derivatives
D560_RS08570	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
D560_RS08575	COG1538	Outer membrane efflux protein
D560_RS08585	COG0351	phosphomethylpyrimidine kinase
D560_RS08590	COG2022	thiamine diphosphate biosynthetic process
D560_RS08620	COG1194	a g-specific adenine glycosylase
D560_RS08630	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
D560_RS08635	COG2177	Part of the ABC transporter FtsEX involved in
D560_RS08640	COG2884	Cell division ATP-binding protein ftsE
D560_RS08645	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D560_RS08650	COG4597	amino acid ABC transporter
D560_RS08655	COG0765	amino acid transport
D560_RS08660	COG1126	abc transporter atp-binding protein
D560_RS08690	COG0477	Major facilitator Superfamily
D560_RS08700	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
D560_RS08705	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
D560_RS08715	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
D560_RS08720	COG0237	dephospho-CoA kinase activity
D560_RS08725	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
D560_RS08735	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D560_RS08750	COG3539	Fimbrial protein
D560_RS08755	COG3539	Fimbrial protein
D560_RS08770	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
D560_RS08780	COG1846	Transcriptional regulator
D560_RS08845	COG1028	Short-chain dehydrogenase reductase Sdr
D560_RS08855	COG1960	acyl-CoA dehydrogenase activity
D560_RS08885	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
D560_RS08890	COG0352	thiamine-phosphate diphosphorylase activity
D560_RS08895	COG0351	phosphomethylpyrimidine kinase
D560_RS08905	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
D560_RS08935	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
D560_RS08945	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D560_RS08950	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
D560_RS08960	COG0557	exoribonuclease II activity
D560_RS08970	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D560_RS08975	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D560_RS08980	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
D560_RS08990	COG0439	Biotin carboxylase
D560_RS08995	COG2264	protein methyltransferase activity
D560_RS09005	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D560_RS09075	COG1522	sequence-specific DNA binding
D560_RS09090	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D560_RS09150	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
D560_RS09175	COG3028	Belongs to the UPF0307 family
D560_RS09185	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
D560_RS09190	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
D560_RS09195	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
D560_RS09205	COG0316	Belongs to the HesB IscA family
D560_RS09215	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
D560_RS09225	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D560_RS09235	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D560_RS09240	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
D560_RS09255	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D560_RS09255	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D560_RS09270	COG2718	Belongs to the UPF0229 family
D560_RS09325	COG0477	Major facilitator Superfamily
D560_RS09340	COG0165	Argininosuccinate lyase
D560_RS09345	COG0589	response to stress
D560_RS09355	COG2816	NAD+ diphosphatase activity
D560_RS09360	COG4993	Dehydrogenase
D560_RS09385	COG3181	Tripartite tricarboxylate transporter family receptor
D560_RS09395	COG4206	TonB-dependent receptor
D560_RS09410	COG0741	lytic transglycosylase activity
D560_RS09410	COG1388	LysM domain
D560_RS09415	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D560_RS09450	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D560_RS09465	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D560_RS09470	COG0842	Transport permease protein
D560_RS09470	COG1129	ABC transporter
D560_RS09475	COG0842	Transport permease protein
D560_RS09495	COG0463	Glycosyl transferase, family 2
D560_RS09500	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
D560_RS09510	COG1073	alpha beta
D560_RS09520	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D560_RS09535	COG2801	Transposase and inactivated derivatives
D560_RS09540	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D560_RS09570	COG0823	Involved in the tonB-independent uptake of proteins
D560_RS09580	COG0848	biopolymer transport protein
D560_RS09585	COG0811	peptide transport
D560_RS09590	COG0824	Thioesterase
D560_RS09595	COG0442	prolyl-tRNA aminoacylation
D560_RS09635	COG2084	Dehydrogenase
D560_RS09670	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
D560_RS09675	COG4654	Cytochrome c, class I
D560_RS09680	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D560_RS09730	COG2801	Transposase and inactivated derivatives
D560_RS09745	COG1473	amidohydrolase
D560_RS09750	COG0418	dihydroorotase activity
D560_RS09755	COG0488	(ABC) transporter
D560_RS09760	COG2001	Belongs to the MraZ family
D560_RS09765	COG0275	rRNA processing
D560_RS09770	COG3116	cell division
D560_RS09780	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
D560_RS09785	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D560_RS09805	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D560_RS09810	COG1181	Belongs to the D-alanine--D-alanine ligase family
D560_RS09815	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
D560_RS09830	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
D560_RS09845	COG0739	heme binding
D560_RS09850	COG0653	protein targeting
D560_RS09865	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
D560_RS09870	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
D560_RS09880	COG0828	Belongs to the bacterial ribosomal protein bS21 family
D560_RS09905	COG2801	Transposase and inactivated derivatives
D560_RS09915	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
D560_RS09930	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
D560_RS09945	COG0583	DNA-binding transcription factor activity
D560_RS09955	COG3181	Tripartite tricarboxylate transporter family receptor
D560_RS09960	COG2084	Dehydrogenase
D560_RS09970	COG1597	lipid kinase activity
D560_RS09970	COG1803	Methylglyoxal synthase
D560_RS10000	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
D560_RS10005	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D560_RS10010	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D560_RS10015	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D560_RS10020	COG0649	NAD binding
D560_RS10025	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
D560_RS10035	COG1034	ATP synthesis coupled electron transport
D560_RS10040	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
D560_RS10045	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D560_RS10055	COG0713	ATP synthesis coupled electron transport
D560_RS10070	COG1007	ATP synthesis coupled electron transport
D560_RS10080	COG0560	Phosphoserine phosphatase
D560_RS10090	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
D560_RS10095	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
D560_RS10105	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D560_RS10110	COG0450	alkyl hydroperoxide reductase
D560_RS10140	COG1573	uracil-dna glycosylase
D560_RS10145	COG0477	Major facilitator Superfamily
D560_RS10150	COG1196	nuclear chromosome segregation
D560_RS10160	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
D560_RS10165	COG1126	abc transporter atp-binding protein
D560_RS10170	COG0765	amino acid transport
D560_RS10175	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D560_RS10180	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D560_RS10185	COG2917	probably involved in intracellular septation
D560_RS10190	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D560_RS10195	COG1122	ATPase activity
D560_RS10200	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
D560_RS10205	COG1268	BioY protein
D560_RS10235	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D560_RS10265	COG2801	Transposase and inactivated derivatives
D560_RS10270	COG2801	Transposase and inactivated derivatives
D560_RS10280	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
D560_RS10285	COG2878	Part of a membrane complex involved in electron transport
D560_RS10305	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
D560_RS10310	COG0251	oxidation-reduction process
D560_RS10320	COG3228	Belongs to the MtfA family
D560_RS10325	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D560_RS10335	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D560_RS10345	COG0159	tryptophan synthase activity
D560_RS10350	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
D560_RS10355	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
D560_RS10365	COG2801	Transposase and inactivated derivatives
D560_RS10370	COG2801	Transposase and inactivated derivatives
D560_RS10375	COG1530	ribonuclease E activity
D560_RS10380	COG0564	pseudouridine synthase activity
D560_RS10385	COG0546	phosphoglycolate phosphatase activity
D560_RS10390	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
D560_RS10395	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
D560_RS10400	COG3023	N-Acetylmuramoyl-L-alanine amidase
D560_RS10410	COG0424	maF-like protein
D560_RS10420	COG0333	Belongs to the bacterial ribosomal protein bL32 family
D560_RS10430	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D560_RS10440	COG1028	Short-chain dehydrogenase reductase Sdr
D560_RS10445	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D560_RS10450	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D560_RS10470	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D560_RS10485	COG0481	GTPase activity
D560_RS10490	COG0681	Belongs to the peptidase S26 family
D560_RS10495	COG0571	ribonuclease III activity
D560_RS10500	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
D560_RS10505	COG1381	Involved in DNA repair and RecF pathway recombination
D560_RS10520	COG0670	Belongs to the BI1 family
D560_RS10535	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
D560_RS10560	COG0583	DNA-binding transcription factor activity
D560_RS10575	COG0791	NLP P60 protein
D560_RS10580	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D560_RS10585	COG3193	protein, possibly involved in utilization of glycolate and propanediol
D560_RS10595	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D560_RS10610	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
D560_RS10645	COG1446	asparaginase
D560_RS10650	COG4172	Belongs to the ABC transporter superfamily
D560_RS10655	COG0747	negative chemotaxis
D560_RS10660	COG0601	transmembrane transport
D560_RS10685	COG0504	CTP synthase activity
D560_RS10695	COG0148	phosphopyruvate hydratase activity
D560_RS10710	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
D560_RS10725	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D560_RS10740	COG2801	Transposase and inactivated derivatives
D560_RS10785	COG0039	L-malate dehydrogenase activity
D560_RS10790	COG2188	Transcriptional regulator
D560_RS10795	COG2009	succinate dehydrogenase
D560_RS10800	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
D560_RS10805	COG1053	succinate dehydrogenase
D560_RS10810	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
D560_RS10815	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
D560_RS10820	COG0372	Belongs to the citrate synthase family
D560_RS10830	COG0583	DNA-binding transcription factor activity
D560_RS10835	COG3842	ATPase activity
D560_RS10845	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D560_RS10850	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D560_RS10860	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D560_RS10870	COG3128	pkhd-type hydroxylase
D560_RS10905	COG0508	dehydrogenase complex catalyzes the overall conversion of
D560_RS10915	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
D560_RS10920	COG1595	DNA-templated transcription, initiation
D560_RS10930	COG4774	siderophore transport
D560_RS10955	COG2183	response to ionizing radiation
D560_RS10960	COG1199	ATP-dependent helicase activity
D560_RS10970	COG0564	pseudouridine synthase activity
D560_RS10985	COG1028	Short-chain dehydrogenase reductase Sdr
D560_RS10990	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
D560_RS11020	COG2823	Periplasmic or secreted lipoprotein
D560_RS11035	COG3237	CsbD-like
D560_RS11040	COG3038	cytochrome b561
D560_RS11055	COG1132	(ABC) transporter
D560_RS11070	COG2833	Protein of unknown function (DUF455)
D560_RS11075	COG2951	lytic endotransglycosylase activity
D560_RS11135	COG2801	Transposase and inactivated derivatives
D560_RS11150	COG0165	Argininosuccinate lyase
D560_RS11170	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D560_RS11185	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
D560_RS11190	COG1605	Chorismate mutase
D560_RS11190	COG0077	Prephenate dehydratase
D560_RS11195	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D560_RS11210	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
D560_RS11230	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
D560_RS11240	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D560_RS11250	COG2951	lytic endotransglycosylase activity
D560_RS11255	COG0123	including yeast histone deacetylase and acetoin utilization protein
D560_RS11270	COG2985	domain, Protein
D560_RS11275	COG1960	acyl-CoA dehydrogenase activity
D560_RS11280	COG0450	alkyl hydroperoxide reductase
D560_RS11285	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
D560_RS11290	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
D560_RS11295	COG4208	sulfate ABC transporter
D560_RS11300	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
D560_RS11305	COG0175	sulfate reduction
D560_RS11330	COG0335	large ribosomal subunit rRNA binding
D560_RS11345	COG3622	Belongs to the hyi family
D560_RS11350	COG1162	GTPase activity
D560_RS11355	COG0501	Belongs to the peptidase M48B family
D560_RS11360	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
D560_RS11365	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
D560_RS11370	COG3327	negative regulation of DNA-templated transcription, initiation
D560_RS11375	COG3396	Phenylacetate-CoA oxygenase
D560_RS11380	COG3460	Phenylacetate-CoA oxygenase
D560_RS11385	COG3396	Phenylacetate-CoA oxygenase
D560_RS11390	COG2151	metal-sulfur cluster biosynthetic enzyme
D560_RS11395	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D560_RS11400	COG1012	belongs to the aldehyde dehydrogenase family
D560_RS11405	COG1024	Enoyl-CoA hydratase
D560_RS11410	COG2050	protein possibly involved in aromatic compounds catabolism
D560_RS11440	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
D560_RS11440	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D560_RS11450	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D560_RS11460	COG2346	COG2346, Truncated hemoglobins
D560_RS11465	COG3642	lipopolysaccharide core region biosynthetic process
D560_RS11475	COG3842	ATPase activity
D560_RS11480	COG1176	ABC-type spermidine putrescine transport system, permease component I
D560_RS11485	COG1177	transmembrane transport
D560_RS11505	COG1322	Protein conserved in bacteria
D560_RS11515	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
D560_RS11520	COG0704	Plays a role in the regulation of phosphate uptake
D560_RS11525	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
D560_RS11530	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
D560_RS11530	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
D560_RS11535	COG1643	Atp-dependent helicase
D560_RS11550	COG0438	transferase activity, transferring glycosyl groups
D560_RS11555	COG0726	polysaccharide deacetylase
D560_RS11560	COG0463	Glycosyl transferase, family 2
D560_RS11590	COG1132	(ABC) transporter
D560_RS11615	COG0501	Belongs to the peptidase M48B family
D560_RS11660	COG1722	exodeoxyribonuclease VII activity
D560_RS11665	COG0142	geranyltranstransferase activity
D560_RS11675	COG1469	GTP cyclohydrolase I activity
D560_RS11680	COG0360	Binds together with S18 to 16S ribosomal RNA
D560_RS11685	COG2965	DNA replication, synthesis of RNA primer
D560_RS11690	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
D560_RS11695	COG0359	binds to the 23S rRNA
D560_RS11705	COG0305	Participates in initiation and elongation during chromosome replication
D560_RS11720	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
D560_RS11725	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
D560_RS11730	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D560_RS11735	COG3737	Protein of unknown function (DUF498/DUF598)
D560_RS11740	COG0436	Aminotransferase
D560_RS11760	COG2801	Transposase and inactivated derivatives
D560_RS11765	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
D560_RS11770	COG0308	aminopeptidase N
D560_RS11785	COG0312	modulator of DNA gyrase
D560_RS11790	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
D560_RS11805	COG2801	Transposase and inactivated derivatives
D560_RS11820	COG0277	FAD linked oxidase domain protein
D560_RS11825	COG0247	lactate metabolic process
D560_RS11860	COG0583	DNA-binding transcription factor activity
D560_RS11865	COG0482	sulfurtransferase activity
D560_RS11870	COG0730	response to heat
D560_RS11875	COG0625	glutathione transferase activity
D560_RS11880	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
D560_RS11885	COG3909	cytochrome
D560_RS11895	COG2801	Transposase and inactivated derivatives
D560_RS11920	COG3706	GGDEF domain
D560_RS11930	COG2801	Transposase and inactivated derivatives
D560_RS11935	COG2826	transposase and inactivated derivatives, IS30 family
D560_RS11955	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
D560_RS11980	COG0069	glutamate synthase activity
D560_RS11985	COG2391	methyltransferase activity
D560_RS11990	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
D560_RS12000	COG2153	protein acetylation
D560_RS12020	COG0557	exoribonuclease II activity
D560_RS12025	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D560_RS12030	COG2873	o-acetylhomoserine
D560_RS12035	COG0776	regulation of translation
D560_RS12065	COG0642	Histidine kinase
D560_RS12070	COG3158	transport of potassium into the cell
D560_RS12085	COG2801	Transposase and inactivated derivatives
D560_RS12090	COG0137	argininosuccinate synthase activity
D560_RS12095	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
D560_RS12100	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D560_RS12110	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D560_RS12125	COG2186	Transcriptional regulator
D560_RS12150	COG3836	Belongs to the HpcH HpaI aldolase family
D560_RS12155	COG0268	Binds directly to 16S ribosomal RNA
D560_RS12175	COG2801	Transposase and inactivated derivatives
D560_RS12180	COG2801	Transposase and inactivated derivatives
D560_RS12210	COG0728	peptidoglycan biosynthetic process
D560_RS12220	COG0563	adenylate kinase activity
D560_RS12225	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
D560_RS12230	COG1663	tetraacyldisaccharide 4'-kinase activity
D560_RS12235	COG0848	biopolymer transport protein
D560_RS12240	COG0811	peptide transport
D560_RS12245	COG1570	exodeoxyribonuclease VII activity
D560_RS12250	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
D560_RS12255	COG2801	Transposase and inactivated derivatives
D560_RS12260	COG0038	chloride channel
D560_RS12265	COG0183	Belongs to the thiolase family
D560_RS12275	COG1278	Cold shock
D560_RS12280	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
D560_RS12310	COG3008	intermembrane lipid transfer
D560_RS12320	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
D560_RS12320	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
D560_RS12320	COG0506	proline dehydrogenase activity
D560_RS12355	COG0004	ammonium transporteR
D560_RS12360	COG0347	Belongs to the P(II) protein family
D560_RS12395	COG0291	Belongs to the bacterial ribosomal protein bL35 family
D560_RS12400	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
D560_RS12405	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
D560_RS12415	COG0776	regulation of translation
D560_RS12440	COG1802	Transcriptional regulator
D560_RS12445	COG3181	Tripartite tricarboxylate transporter family receptor
D560_RS12455	COG0473	3-isopropylmalate dehydrogenase activity
D560_RS12465	COG1278	Cold shock
D560_RS12495	COG1522	sequence-specific DNA binding
D560_RS12545	COG5265	(ABC) transporter
D560_RS12550	COG0656	L-ascorbic acid biosynthetic process
D560_RS12560	COG2801	Transposase and inactivated derivatives
D560_RS12565	COG0656	L-ascorbic acid biosynthetic process
D560_RS12570	COG0667	Aldo Keto reductase
D560_RS12585	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
D560_RS12620	COG1610	YqeY-like protein
D560_RS12635	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D560_RS12640	COG3246	L-lysine catabolic process to acetate
D560_RS12645	COG1250	3-hydroxyacyl-CoA dehydrogenase
D560_RS12655	COG0318	PFAM AMP-dependent synthetase and ligase
D560_RS12670	COG0183	Belongs to the thiolase family
D560_RS12675	COG1250	3-hydroxyacyl-CoA dehydrogenase
D560_RS12675	COG1024	Enoyl-CoA hydratase
D560_RS12685	COG1250	3-hydroxyacyl-CoA dehydrogenase
D560_RS12685	COG1024	Enoyl-CoA hydratase
D560_RS12690	COG0183	Belongs to the thiolase family
D560_RS12695	COG1960	acyl-CoA dehydrogenase activity
D560_RS12705	COG1045	serine acetyltransferase
D560_RS12715	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
D560_RS12720	COG0483	inositol monophosphate 1-phosphatase activity
D560_RS12725	COG1012	belongs to the aldehyde dehydrogenase family
D560_RS12730	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D560_RS12750	COG0598	Magnesium transport protein CorA
D560_RS12760	COG0747	negative chemotaxis
D560_RS12765	COG0601	transmembrane transport
D560_RS12770	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D560_RS12775	COG4172	Belongs to the ABC transporter superfamily
D560_RS12795	COG1346	cytolysis
D560_RS12805	COG1028	Short-chain dehydrogenase reductase Sdr
D560_RS12810	COG0783	Belongs to the Dps family
D560_RS12830	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
D560_RS12840	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D560_RS12845	COG1845	cytochrome c oxidase, subunit III
D560_RS12850	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
D560_RS12865	COG2801	Transposase and inactivated derivatives
D560_RS12870	COG2801	Transposase and inactivated derivatives
D560_RS12900	COG1666	GTP binding
D560_RS12930	COG5006	permease, DMT superfamily
D560_RS12955	COG2264	protein methyltransferase activity
D560_RS12990	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
D560_RS12995	COG0746	molybdenum cofactor guanylyltransferase activity
D560_RS13000	COG0303	'Molybdopterin
D560_RS13005	COG0521	Mo-molybdopterin cofactor biosynthetic process
D560_RS13010	COG0314	molybdopterin synthase activity
D560_RS13020	COG0315	cyclic pyranopterin monophosphate synthase activity
D560_RS13025	COG0412	Dienelactone hydrolase
D560_RS13035	COG0678	peroxiredoxin activity
D560_RS13050	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D560_RS13070	COG1477	protein flavinylation
D560_RS13095	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D560_RS13100	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
D560_RS13100	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
D560_RS13105	COG1562	ergosterol biosynthetic process
D560_RS13110	COG1562	ergosterol biosynthetic process
D560_RS13120	COG1028	Short-chain dehydrogenase reductase Sdr
D560_RS13155	COG0254	rRNA binding
D560_RS13160	COG3483	tryptophan 2,3-dioxygenase activity
D560_RS13165	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
D560_RS13170	COG2003	Belongs to the UPF0758 family
D560_RS13180	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
D560_RS13185	COG0625	glutathione transferase activity
D560_RS13215	COG0583	DNA-binding transcription factor activity
D560_RS13225	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
D560_RS13230	COG1187	pseudouridine synthase activity
D560_RS13235	COG0779	Required for maturation of 30S ribosomal subunits
D560_RS13240	COG0195	Participates in both transcription termination and antitermination
D560_RS13240	COG2251	uridine kinase activity
D560_RS13245	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
D560_RS13250	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
D560_RS13255	COG1217	gtp-binding protein TYPA
D560_RS13270	COG1802	Transcriptional regulator
D560_RS13280	COG1024	Enoyl-CoA hydratase
D560_RS13295	COG2032	superoxide dismutase activity
D560_RS13315	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
D560_RS13320	COG0725	ABC transporter, periplasmic molybdate-binding protein
D560_RS13325	COG4149	molybdate abc transporter
D560_RS13355	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D560_RS13360	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D560_RS13365	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D560_RS13375	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
D560_RS13380	COG0736	holo-[acyl-carrier-protein] synthase activity
D560_RS13385	COG1472	Belongs to the glycosyl hydrolase 3 family
D560_RS13395	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D560_RS13405	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
D560_RS13405	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
D560_RS13410	COG2224	Isocitrate lyase
D560_RS13415	COG1846	Transcriptional regulator
D560_RS13420	COG1764	response to oxidative stress
D560_RS13425	COG1131	(ABC) transporter
D560_RS13430	COG0842	Transport permease protein
D560_RS13435	COG0628	permease
D560_RS13450	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
D560_RS13460	COG2814	Major facilitator Superfamily
D560_RS13490	COG3530	Putative quorum-sensing-regulated virulence factor
D560_RS13505	COG0494	nUDIX hydrolase
D560_RS13515	COG0697	spore germination
D560_RS13520	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
D560_RS13550	COG1702	phosphate starvation-inducible protein PhoH
D560_RS13555	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
D560_RS13560	COG4535	Mg2 and Co2 transporter CorC
D560_RS13565	COG0815	Transfers the fatty acyl group on membrane lipoproteins
D560_RS13570	COG0667	Aldo Keto reductase
D560_RS13590	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D560_RS13600	COG1862	Preprotein translocase
D560_RS13605	COG0343	queuine tRNA-ribosyltransferase activity
D560_RS13615	COG2027	D-alanyl-D-alanine carboxypeptidase
D560_RS13620	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
D560_RS13635	COG4575	ribosome binding
D560_RS13655	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
D560_RS13660	COG0741	lytic transglycosylase activity
D560_RS13665	COG0436	Aminotransferase
D560_RS13675	COG0281	malic enzyme
D560_RS13675	COG0280	phosphate acetyltransferase
D560_RS13690	COG1385	rRNA (uridine-N3-)-methyltransferase activity
D560_RS13695	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
D560_RS13700	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D560_RS13705	COG0126	phosphoglycerate kinase activity
D560_RS13725	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
D560_RS13740	COG0625	glutathione transferase activity
D560_RS13760	COG0789	Transcriptional regulator
D560_RS13775	COG0306	phosphate transporter
D560_RS13780	COG0521	Mo-molybdopterin cofactor biosynthetic process
D560_RS13790	COG0739	heme binding
D560_RS13800	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
D560_RS13825	COG2801	Transposase and inactivated derivatives
D560_RS13830	COG2801	Transposase and inactivated derivatives
D560_RS13850	COG0456	acetyltransferase
D560_RS13855	COG1301	dicarboxylic acid transport
D560_RS13865	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
D560_RS13870	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
D560_RS13875	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
D560_RS13880	COG0009	L-threonylcarbamoyladenylate synthase
D560_RS13920	COG1960	acyl-CoA dehydrogenase activity
D560_RS13925	COG0028	Belongs to the TPP enzyme family
D560_RS13930	COG0583	DNA-binding transcription factor activity
D560_RS13935	COG4974	Belongs to the 'phage' integrase family
D560_RS13940	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
D560_RS13945	COG1686	Belongs to the peptidase S11 family
D560_RS13970	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
D560_RS13975	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
D560_RS14000	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D560_RS14005	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
D560_RS14010	COG0505	Belongs to the CarA family
D560_RS14030	COG0406	alpha-ribazole phosphatase activity
D560_RS14060	COG2233	PERMEase
D560_RS14065	COG3620	sequence-specific DNA binding
D560_RS14075	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D560_RS14085	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
D560_RS14090	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D560_RS14100	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D560_RS14115	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
D560_RS14130	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D560_RS14145	COG2963	transposase activity
D560_RS14150	COG2801	Transposase and inactivated derivatives
D560_RS14180	COG2801	Transposase and inactivated derivatives
D560_RS14200	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D560_RS14235	COG0540	Belongs to the ATCase OTCase family
D560_RS14240	COG2974	May be involved in recombination
D560_RS14265	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
D560_RS14280	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
D560_RS14295	COG0045	succinate-CoA ligase (ADP-forming) activity
D560_RS14300	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
D560_RS14305	COG0861	Integral membrane protein TerC family
D560_RS14310	COG0861	Integral membrane protein TerC family
D560_RS14320	COG0181	hydroxymethylbilane synthase activity
D560_RS14360	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D560_RS14415	COG2801	Transposase and inactivated derivatives
D560_RS14445	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D560_RS14455	COG1295	ribonuclease BN
D560_RS14485	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
D560_RS14490	COG0501	Belongs to the peptidase M48B family
D560_RS14495	COG2197	response regulator
D560_RS14500	COG2801	Transposase and inactivated derivatives
D560_RS14520	COG0066	3-isopropylmalate dehydratase activity
D560_RS14530	COG0473	3-isopropylmalate dehydrogenase activity
D560_RS14535	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D560_RS14565	COG2801	Transposase and inactivated derivatives
D560_RS14570	COG2963	transposase activity
D560_RS14575	COG2801	Transposase and inactivated derivatives
D560_RS14595	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D560_RS14600	COG2197	response regulator
D560_RS14605	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
D560_RS14610	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
D560_RS14625	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D560_RS14630	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D560_RS14640	COG1764	response to oxidative stress
D560_RS14655	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D560_RS14660	COG0765	amino acid transport
D560_RS14665	COG0765	amino acid transport
D560_RS14670	COG1126	abc transporter atp-binding protein
D560_RS14675	COG0756	dUTP diphosphatase activity
D560_RS14705	COG1522	sequence-specific DNA binding
D560_RS14720	COG2801	Transposase and inactivated derivatives
D560_RS14725	COG2801	Transposase and inactivated derivatives
D560_RS14730	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
D560_RS14735	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
D560_RS14740	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
D560_RS14745	COG0196	riboflavin kinase activity
D560_RS14755	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
D560_RS14755	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D560_RS14770	COG2801	Transposase and inactivated derivatives
D560_RS14785	COG4771	TonB-dependent receptor
D560_RS14790	COG0488	(ABC) transporter
D560_RS14795	COG2890	protein-(glutamine-N5) methyltransferase activity
D560_RS14800	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D560_RS14805	COG2171	N-acyltransferase activity
D560_RS14855	COG2801	Transposase and inactivated derivatives
D560_RS14875	COG2801	Transposase and inactivated derivatives
D560_RS14900	COG2814	Major facilitator Superfamily
D560_RS14925	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D560_RS14930	COG2900	Belongs to the SlyX family
D560_RS14945	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D560_RS14965	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D560_RS14990	COG0257	Belongs to the bacterial ribosomal protein bL36 family
D560_RS14995	COG0583	DNA-binding transcription factor activity
D560_RS15000	COG1028	Short-chain dehydrogenase reductase Sdr
D560_RS15010	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D560_RS15015	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D560_RS15025	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D560_RS15035	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
D560_RS15045	COG4566	intracellular signal transduction
D560_RS15050	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
D560_RS15070	COG1999	signal sequence binding
D560_RS15090	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D560_RS15095	COG0583	DNA-binding transcription factor activity
D560_RS15100	COG1187	pseudouridine synthase activity
D560_RS15105	COG3161	chorismate lyase activity
D560_RS15165	COG0583	DNA-binding transcription factor activity
D560_RS15175	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D560_RS15200	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
D560_RS15215	COG1183	phosphatidylcholine synthase activity
D560_RS15225	COG0440	acetolactate synthase activity
D560_RS15230	COG0028	Belongs to the TPP enzyme family
D560_RS15255	COG3022	response to hydroperoxide
D560_RS15265	COG1028	Short-chain dehydrogenase reductase Sdr
D560_RS15280	COG3486	L-lysine 6-monooxygenase (NADPH) activity
D560_RS15330	COG2801	Transposase and inactivated derivatives
D560_RS15335	COG2801	Transposase and inactivated derivatives
D560_RS15385	COG2733	membrane
D560_RS15405	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
D560_RS15425	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D560_RS15430	COG0842	Transport permease protein
D560_RS15430	COG1129	ABC transporter
D560_RS15435	COG0842	Transport permease protein
D560_RS15445	COG1028	Short-chain dehydrogenase reductase Sdr
D560_RS15455	COG2259	Doxx family
D560_RS15485	COG0415	Belongs to the DNA photolyase family
D560_RS15505	COG0386	Belongs to the glutathione peroxidase family
D560_RS15520	COG0095	Lipoate-protein ligase
D560_RS15530	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D560_RS15540	COG0010	Belongs to the arginase family
D560_RS15550	COG0765	amino acid transport
D560_RS15555	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D560_RS15570	COG0084	hydrolase, TatD family'
D560_RS15580	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
D560_RS15585	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
D560_RS15595	COG2175	clavaminate synthase activity
D560_RS15600	COG0583	DNA-binding transcription factor activity
D560_RS15625	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
D560_RS15630	COG1960	acyl-CoA dehydrogenase activity
D560_RS15640	COG2914	Belongs to the UPF0125 (RnfH) family
D560_RS15650	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
D560_RS15685	COG0519	Catalyzes the synthesis of GMP from XMP
D560_RS15685	COG0518	GMP synthase (glutamine-hydrolyzing) activity
D560_RS15695	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
D560_RS15705	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D560_RS15710	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
D560_RS15715	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D560_RS15725	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D560_RS15730	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D560_RS15740	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D560_RS15750	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
D560_RS15760	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D560_RS15765	COG0233	cytoplasmic translational termination
D560_RS15770	COG0528	UMP kinase activity
D560_RS15775	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
D560_RS15780	COG0052	Belongs to the universal ribosomal protein uS2 family
D560_RS15785	COG0024	Methionine aminopeptidase
D560_RS15790	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
D560_RS15810	COG1286	toxin biosynthetic process
D560_RS15830	COG3181	Tripartite tricarboxylate transporter family receptor
D560_RS15835	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D560_RS15855	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
D560_RS15885	COG1677	Flagellar hook-basal body complex protein FliE
D560_RS15895	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D560_RS15900	COG1317	bacterial-type flagellum organization
D560_RS15920	COG1580	Controls the rotational direction of flagella during chemotaxis
D560_RS15930	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D560_RS15955	COG0840	transmembrane signaling receptor activity
D560_RS15980	COG1191	sigma factor activity
D560_RS15990	COG2801	Transposase and inactivated derivatives
D560_RS15995	COG2801	Transposase and inactivated derivatives
D560_RS16020	COG2203	Gaf domain
D560_RS16020	COG2199	diguanylate cyclase activity
D560_RS16030	COG1619	proteins homologs of microcin C7 resistance protein MccF
D560_RS16050	COG1126	abc transporter atp-binding protein
D560_RS16055	COG0765	amino acid transport
D560_RS16060	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D560_RS16105	COG2200	EAL domain
D560_RS16120	COG1253	flavin adenine dinucleotide binding
D560_RS16130	COG2197	response regulator
D560_RS16155	COG2801	Transposase and inactivated derivatives
D560_RS16160	COG0076	glutamate decarboxylase activity
D560_RS16165	COG2985	domain, Protein
D560_RS16170	COG3189	MarR family transcriptional regulator
D560_RS16180	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D560_RS16190	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D560_RS16190	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
D560_RS16220	COG0688	phosphatidylethanolamine metabolic process
D560_RS16225	COG1304	FMN binding
D560_RS16230	COG1464	Belongs to the NlpA lipoprotein family
D560_RS16235	COG2801	Transposase and inactivated derivatives
D560_RS16245	COG0697	spore germination
D560_RS16250	COG2133	pyrroloquinoline quinone binding
D560_RS16255	COG0625	glutathione transferase activity
D560_RS16265	COG1794	racemase activity, acting on amino acids and derivatives
D560_RS16285	COG0559	Belongs to the binding-protein-dependent transport system permease family
D560_RS16295	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
D560_RS16310	COG1175	transmembrane transport
D560_RS16315	COG0395	ABC-type sugar transport system, permease component
D560_RS16320	COG3842	ATPase activity
D560_RS16355	COG0438	transferase activity, transferring glycosyl groups
D560_RS16395	COG0783	Belongs to the Dps family
D560_RS16400	COG0583	DNA-binding transcription factor activity
D560_RS16405	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
D560_RS16430	COG1840	ABC-type Fe3 transport system, periplasmic component
D560_RS16440	COG3842	ATPase activity
D560_RS16445	COG1741	Belongs to the pirin family
D560_RS16470	COG0174	glutamine synthetase
D560_RS16475	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D560_RS16480	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
D560_RS16490	COG0840	transmembrane signaling receptor activity
D560_RS16500	COG0583	DNA-binding transcription factor activity
D560_RS16510	COG2079	MmgE PrpD family protein
D560_RS16520	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
D560_RS16525	COG1561	YicC-like family, N-terminal region
D560_RS16535	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
D560_RS16540	COG0791	NLP P60 protein
D560_RS16545	COG1028	Short-chain dehydrogenase reductase Sdr
D560_RS16550	COG0194	GDP metabolic process
D560_RS16555	COG1758	RNA polymerase activity
D560_RS16560	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D560_RS16565	COG1126	abc transporter atp-binding protein
D560_RS16570	COG0765	amino acid transport
D560_RS16575	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D560_RS16585	COG2831	hemolysin activation secretion protein
D560_RS16595	COG3188	usher protein
D560_RS16600	COG3121	Chaperone
D560_RS16615	COG3210	domain, Protein
D560_RS16615	COG3064	Membrane
D560_RS16615	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
D560_RS16615	COG3064	Membrane
D560_RS16615	COG3210	domain, Protein
D560_RS16615	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
D560_RS16625	COG4181	ATPase activity
D560_RS16635	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D560_RS16640	COG0584	glycerophosphoryl diester phosphodiesterase
D560_RS16645	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
D560_RS16655	COG0678	peroxiredoxin activity
D560_RS16655	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D560_RS16665	COG2217	Heavy metal translocating P-type atpase
D560_RS16670	COG0789	Transcriptional regulator
D560_RS16675	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D560_RS16685	COG2801	Transposase and inactivated derivatives
D560_RS16710	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
D560_RS16720	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
D560_RS16745	COG0583	DNA-binding transcription factor activity
D560_RS16750	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
D560_RS16755	COG2252	PERMEase
D560_RS16760	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D560_RS16765	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D560_RS16800	COG0488	(ABC) transporter
D560_RS16805	COG1619	proteins homologs of microcin C7 resistance protein MccF
D560_RS16810	COG0590	tRNA wobble adenosine to inosine editing
D560_RS16825	COG1320	monovalent cation:proton antiporter activity
D560_RS16830	COG2212	antiporter activity
D560_RS16835	COG1863	multisubunit Na H antiporter MnhE subunit
D560_RS16840	COG0651	ATP synthesis coupled electron transport
D560_RS16845	COG1006	Multisubunit Na H antiporter MnhC subunit
D560_RS16850	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D560_RS16850	COG2111	Na H antiporter
D560_RS16855	COG3181	Tripartite tricarboxylate transporter family receptor
D560_RS16875	COG0420	3'-5' exonuclease activity
D560_RS16905	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D560_RS16915	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
D560_RS16925	COG2130	NADP-dependent
D560_RS16930	COG1309	transcriptional regulator
D560_RS16940	COG1131	(ABC) transporter
D560_RS16945	COG0842	Transport permease protein
D560_RS16955	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
D560_RS16990	COG0602	queuosine metabolic process
D560_RS16995	COG0720	synthase
D560_RS17010	COG0840	transmembrane signaling receptor activity
D560_RS17030	COG0587	DNA-directed DNA polymerase activity
D560_RS17045	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D560_RS17050	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
D560_RS17100	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
D560_RS17125	COG5507	3-demethylubiquinone-9 3-methyltransferase
D560_RS17160	COG1396	sequence-specific DNA binding
D560_RS17175	COG2801	Transposase and inactivated derivatives
D560_RS17180	COG2801	Transposase and inactivated derivatives
D560_RS17190	COG0583	DNA-binding transcription factor activity
D560_RS17195	COG2814	Major facilitator Superfamily
D560_RS17225	COG2207	Transcriptional regulator
D560_RS17230	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
D560_RS17235	COG2814	Major facilitator Superfamily
D560_RS17285	COG0583	DNA-binding transcription factor activity
D560_RS17305	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D560_RS17330	COG0384	phenazine biosynthesis protein PhzF
D560_RS17335	COG1733	regulation of RNA biosynthetic process
D560_RS17380	COG0518	GMP synthase (glutamine-hydrolyzing) activity
D560_RS17380	COG0519	Catalyzes the synthesis of GMP from XMP
D560_RS17395	COG1695	Transcriptional regulator
D560_RS17410	COG2072	flavoprotein involved in K transport
D560_RS17415	COG0601	transmembrane transport
D560_RS17430	COG2801	Transposase and inactivated derivatives
D560_RS17435	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D560_RS17445	COG4608	Belongs to the ABC transporter superfamily
D560_RS17495	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
D560_RS17500	COG2801	Transposase and inactivated derivatives
D560_RS17510	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D560_RS17510	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
D560_RS17515	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D560_RS17525	COG0613	PHP domain protein
D560_RS17585	COG1012	belongs to the aldehyde dehydrogenase family
D560_RS17615	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D560_RS17625	COG3181	Tripartite tricarboxylate transporter family receptor
D560_RS17630	COG2963	transposase activity
D560_RS17635	COG3181	Tripartite tricarboxylate transporter family receptor
D560_RS17665	COG1595	DNA-templated transcription, initiation
D560_RS17670	COG3712	iron ion homeostasis
D560_RS17680	COG0084	hydrolase, TatD family'
D560_RS17685	COG1136	(ABC) transporter
D560_RS17705	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
D560_RS17710	COG1028	Short-chain dehydrogenase reductase Sdr
D560_RS17715	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
D560_RS17720	COG1803	Methylglyoxal synthase
D560_RS17740	COG2801	Transposase and inactivated derivatives
D560_RS17755	COG2963	transposase activity
D560_RS17765	COG2975	iron-sulfur cluster assembly
D560_RS17770	COG0633	Ferredoxin
D560_RS17775	COG0443	Heat shock 70 kDa protein
D560_RS17780	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
D560_RS17785	COG0316	Belongs to the HesB IscA family
D560_RS17790	COG0822	iron-sulfur transferase activity
D560_RS17795	COG1104	cysteine desulfurase activity
D560_RS17805	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D560_RS17810	COG0556	nucleotide-excision repair
D560_RS17820	COG2801	Transposase and inactivated derivatives
D560_RS17845	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D560_RS17865	COG2801	Transposase and inactivated derivatives
D560_RS17870	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
D560_RS17880	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D560_RS17895	COG0544	peptidyl-prolyl cis-trans isomerase activity
D560_RS17925	COG2801	Transposase and inactivated derivatives
D560_RS17935	COG1278	Cold shock
D560_RS17965	COG2433	Pfam Transposase IS66
D560_RS17980	COG2801	Transposase and inactivated derivatives
D560_RS18045	COG2200	EAL domain
D560_RS18085	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
D560_RS18090	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
D560_RS18150	COG2801	Transposase and inactivated derivatives