locus-tag	class	description
B2B12_RS00005	COG0445	tRNA wobble uridine modification
B2B12_RS00010	COG0357	Ribosomal RNA small subunit methyltransferase G
B2B12_RS00015	COG1192	Involved in chromosome partitioning
B2B12_RS00020	COG1475	DNA binding
B2B12_RS00025	COG0252	asparaginase activity
B2B12_RS00045	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B2B12_RS00055	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
B2B12_RS00065	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
B2B12_RS00070	COG0081	regulation of translation
B2B12_RS00075	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
B2B12_RS00080	COG0222	ribosome binding
B2B12_RS00085	COG0085	RNA polymerase activity
B2B12_RS00090	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
B2B12_RS00125	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
B2B12_RS00130	COG0049	tRNA binding
B2B12_RS00135	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
B2B12_RS00140	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B2B12_RS00145	COG0051	transcription antitermination factor activity, RNA binding
B2B12_RS00150	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
B2B12_RS00155	COG0088	Forms part of the polypeptide exit tunnel
B2B12_RS00160	COG0089	rRNA binding
B2B12_RS00165	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
B2B12_RS00170	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
B2B12_RS00175	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
B2B12_RS00180	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
B2B12_RS00185	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
B2B12_RS00190	COG0255	Belongs to the universal ribosomal protein uL29 family
B2B12_RS00195	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
B2B12_RS00205	COG4177	L-phenylalanine transmembrane transporter activity
B2B12_RS00215	COG1129	ABC transporter
B2B12_RS00220	COG0411	ABC transporter
B2B12_RS00250	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
B2B12_RS00255	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
B2B12_RS00260	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
B2B12_RS00265	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
B2B12_RS00270	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
B2B12_RS00275	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
B2B12_RS00280	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
B2B12_RS00285	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
B2B12_RS00290	COG1841	ribosomal large subunit assembly
B2B12_RS00295	COG0200	Binds to the 23S rRNA
B2B12_RS00300	COG0201	protein transport
B2B12_RS00305	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
B2B12_RS00310	COG0257	Belongs to the bacterial ribosomal protein bL36 family
B2B12_RS00315	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
B2B12_RS00320	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
B2B12_RS00325	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
B2B12_RS00330	COG0202	RNA polymerase activity
B2B12_RS00335	COG0203	ribosomal protein L17
B2B12_RS00340	COG0537	adenosine 5'-monophosphoramidase activity
B2B12_RS00345	COG1324	tolerance protein
B2B12_RS00350	COG4232	protein-disulfide reductase activity
B2B12_RS00365	COG0218	Necessary for normal cell division and for the maintenance of normal septation
B2B12_RS00375	COG1333	cytochrome c biogenesis protein
B2B12_RS00380	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B2B12_RS00395	COG1965	Belongs to the frataxin family
B2B12_RS00405	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
B2B12_RS00410	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
B2B12_RS00415	COG0232	Belongs to the dGTPase family. Type 2 subfamily
B2B12_RS00435	COG2814	Major facilitator Superfamily
B2B12_RS00460	COG2801	Transposase and inactivated derivatives
B2B12_RS00490	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B2B12_RS00495	COG2922	Belongs to the Smg family
B2B12_RS00500	COG1629	transport
B2B12_RS00510	COG2358	TRAP transporter, solute receptor (TAXI family
B2B12_RS00520	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B2B12_RS00535	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B2B12_RS00540	COG0183	Belongs to the thiolase family
B2B12_RS00545	COG1960	acyl-CoA dehydrogenase activity
B2B12_RS00570	COG2200	EAL domain
B2B12_RS00575	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
B2B12_RS00585	COG0018	arginyl-trna synthetase
B2B12_RS00600	COG0154	amidase activity
B2B12_RS00605	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B2B12_RS00615	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
B2B12_RS00625	COG0697	spore germination
B2B12_RS00685	COG3350	monooxygenase activity
B2B12_RS00710	COG1309	transcriptional regulator
B2B12_RS00740	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
B2B12_RS00745	COG1280	lysine exporter protein (LysE YggA)
B2B12_RS00750	COG0513	Belongs to the DEAD box helicase family
B2B12_RS00760	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
B2B12_RS00765	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
B2B12_RS00795	COG2969	positive regulation of protein catabolic process
B2B12_RS00800	COG0625	glutathione transferase activity
B2B12_RS00805	COG2857	Cytochrome c1
B2B12_RS00810	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
B2B12_RS00815	COG0723	plastoquinol--plastocyanin reductase activity
B2B12_RS00820	COG1970	mechanosensitive ion channel activity
B2B12_RS00825	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
B2B12_RS00830	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B2B12_RS00840	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B2B12_RS00845	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B2B12_RS00855	COG0140	phosphoribosyl-ATP diphosphatase activity
B2B12_RS00860	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
B2B12_RS00865	COG0107	imidazoleglycerol-phosphate synthase activity
B2B12_RS00870	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
B2B12_RS00880	COG0131	Imidazoleglycerol-phosphate dehydratase
B2B12_RS00885	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B2B12_RS00890	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
B2B12_RS00895	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
B2B12_RS00900	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
B2B12_RS00905	COG0271	Belongs to the BolA IbaG family
B2B12_RS00910	COG0842	Transport permease protein
B2B12_RS00915	COG1131	(ABC) transporter
B2B12_RS00930	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
B2B12_RS00935	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
B2B12_RS00940	COG1127	ABC transporter
B2B12_RS00960	COG0067	glutamate synthase
B2B12_RS00960	COG0069	glutamate synthase activity
B2B12_RS00960	COG0070	glutamate synthase
B2B12_RS00985	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
B2B12_RS01010	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
B2B12_RS01015	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
B2B12_RS01055	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
B2B12_RS01090	COG0109	protoheme IX farnesyltransferase activity
B2B12_RS01095	COG1999	signal sequence binding
B2B12_RS01115	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
B2B12_RS01120	COG2814	Major facilitator Superfamily
B2B12_RS01135	COG1522	sequence-specific DNA binding
B2B12_RS01195	COG4948	Mandelate Racemase Muconate Lactonizing
B2B12_RS01210	COG3119	arylsulfatase activity
B2B12_RS01250	COG0402	S-adenosylhomocysteine deaminase activity
B2B12_RS01260	COG1304	FMN binding
B2B12_RS01265	COG1254	Belongs to the acylphosphatase family
B2B12_RS01275	COG3181	Tripartite tricarboxylate transporter family receptor
B2B12_RS01285	COG1414	Transcriptional regulator
B2B12_RS01305	COG0028	Belongs to the TPP enzyme family
B2B12_RS01310	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
B2B12_RS01315	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B2B12_RS01320	COG1960	acyl-CoA dehydrogenase activity
B2B12_RS01355	COG3181	Tripartite tricarboxylate transporter family receptor
B2B12_RS01360	COG0583	DNA-binding transcription factor activity
B2B12_RS01375	COG0129	dihydroxy-acid dehydratase activity
B2B12_RS01380	COG2084	Dehydrogenase
B2B12_RS01395	COG1671	Belongs to the UPF0178 family
B2B12_RS01400	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
B2B12_RS01415	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
B2B12_RS01420	COG0443	Heat shock 70 kDa protein
B2B12_RS01445	COG2169	Transcriptional regulator
B2B12_RS01445	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
B2B12_RS01460	COG1683	Conserved Protein
B2B12_RS01465	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B2B12_RS01480	COG1120	ATPase activity
B2B12_RS01485	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B2B12_RS01490	COG4558	Periplasmic binding protein
B2B12_RS01495	COG3720	iron ion transport
B2B12_RS01505	COG3712	iron ion homeostasis
B2B12_RS01510	COG1595	DNA-templated transcription, initiation
B2B12_RS01530	COG1607	acyl-coa hydrolase
B2B12_RS01540	COG3383	formate dehydrogenase (NAD+) activity
B2B12_RS01540	COG0243	molybdopterin cofactor binding
B2B12_RS01545	COG3383	formate dehydrogenase (NAD+) activity
B2B12_RS01545	COG0243	molybdopterin cofactor binding
B2B12_RS01550	COG0437	4 iron, 4 sulfur cluster binding
B2B12_RS01555	COG2864	formate dehydrogenase
B2B12_RS01570	COG3276	selenocysteine insertion sequence binding
B2B12_RS01605	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
B2B12_RS01610	COG0512	Glutamine amidotransferase of anthranilate synthase
B2B12_RS01620	COG0546	phosphoglycolate phosphatase activity
B2B12_RS01625	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
B2B12_RS01630	COG2967	ApaG domain
B2B12_RS01635	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
B2B12_RS01640	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B2B12_RS01645	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
B2B12_RS01650	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B2B12_RS01655	COG0037	tRNA processing
B2B12_RS01675	COG1024	Enoyl-CoA hydratase
B2B12_RS01690	COG0356	it plays a direct role in the translocation of protons across the membrane
B2B12_RS01700	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
B2B12_RS01705	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B2B12_RS01710	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
B2B12_RS01715	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
B2B12_RS01720	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
B2B12_RS01725	COG0355	proton-transporting ATP synthase activity, rotational mechanism
B2B12_RS01740	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
B2B12_RS01745	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
B2B12_RS01750	COG0210	DNA helicase
B2B12_RS01765	COG4608	Belongs to the ABC transporter superfamily
B2B12_RS01770	COG0444	Belongs to the ABC transporter superfamily
B2B12_RS01775	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B2B12_RS01800	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
B2B12_RS01805	COG1024	Enoyl-CoA hydratase
B2B12_RS01810	COG1024	Enoyl-CoA hydratase
B2B12_RS01815	COG2070	2-Nitropropane dioxygenase
B2B12_RS01830	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B2B12_RS01835	COG1250	3-hydroxyacyl-CoA dehydrogenase
B2B12_RS01855	COG2267	carboxylic ester hydrolase activity
B2B12_RS01875	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
B2B12_RS01885	COG2813	Specifically methylates the guanine in position
B2B12_RS01885	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
B2B12_RS01890	COG2223	nitrite transmembrane transporter activity
B2B12_RS01895	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
B2B12_RS01910	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
B2B12_RS01915	COG0708	Exodeoxyribonuclease III
B2B12_RS01920	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
B2B12_RS01925	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B2B12_RS01930	COG0154	amidase activity
B2B12_RS01935	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B2B12_RS01940	COG1077	Cell shape determining protein MreB Mrl
B2B12_RS01945	COG1792	Involved in formation and maintenance of cell shape
B2B12_RS01955	COG0768	penicillin binding
B2B12_RS01960	COG0772	Belongs to the SEDS family
B2B12_RS01965	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
B2B12_RS01970	COG0471	metal ion transport
B2B12_RS01975	COG1309	transcriptional regulator
B2B12_RS01985	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
B2B12_RS02000	COG2823	Periplasmic or secreted lipoprotein
B2B12_RS02005	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
B2B12_RS02010	COG0792	nuclease activity
B2B12_RS02030	COG1660	Displays ATPase and GTPase activities
B2B12_RS02045	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
B2B12_RS02055	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
B2B12_RS02065	COG3181	Tripartite tricarboxylate transporter family receptor
B2B12_RS02070	COG1473	amidohydrolase
B2B12_RS02075	COG1137	ATPase activity
B2B12_RS02090	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
B2B12_RS02100	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
B2B12_RS02120	COG1294	oxidase, subunit
B2B12_RS02130	COG4988	ABC transporter
B2B12_RS02135	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
B2B12_RS02140	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B2B12_RS02155	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
B2B12_RS02160	COG1238	metal cluster binding
B2B12_RS02170	COG1802	Transcriptional regulator
B2B12_RS02180	COG1984	allophanate hydrolase subunit 2
B2B12_RS02185	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
B2B12_RS02195	COG0583	DNA-binding transcription factor activity
B2B12_RS02200	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B2B12_RS02205	COG5002	protein histidine kinase activity
B2B12_RS02210	COG0745	RESPONSE REGULATOR receiver
B2B12_RS02215	COG2226	methyltransferase
B2B12_RS02260	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B2B12_RS02270	COG1028	Short-chain dehydrogenase reductase Sdr
B2B12_RS02290	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
B2B12_RS02295	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
B2B12_RS02305	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
B2B12_RS02325	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
B2B12_RS02330	COG1538	Outer membrane efflux protein
B2B12_RS02340	COG0351	phosphomethylpyrimidine kinase
B2B12_RS02345	COG2022	thiamine diphosphate biosynthetic process
B2B12_RS02350	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B2B12_RS02370	COG2226	methyltransferase
B2B12_RS02380	COG1194	a g-specific adenine glycosylase
B2B12_RS02390	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
B2B12_RS02395	COG2177	Part of the ABC transporter FtsEX involved in
B2B12_RS02400	COG2884	Cell division ATP-binding protein ftsE
B2B12_RS02405	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B2B12_RS02410	COG4597	amino acid ABC transporter
B2B12_RS02415	COG0765	amino acid transport
B2B12_RS02420	COG1126	abc transporter atp-binding protein
B2B12_RS02450	COG0477	Major facilitator Superfamily
B2B12_RS02460	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
B2B12_RS02465	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
B2B12_RS02480	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
B2B12_RS02485	COG0237	dephospho-CoA kinase activity
B2B12_RS02490	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
B2B12_RS02500	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B2B12_RS02515	COG3539	Fimbrial protein
B2B12_RS02520	COG3539	Fimbrial protein
B2B12_RS02535	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
B2B12_RS02545	COG1846	Transcriptional regulator
B2B12_RS02610	COG1028	Short-chain dehydrogenase reductase Sdr
B2B12_RS02615	COG1024	Enoyl-CoA hydratase
B2B12_RS02620	COG1960	acyl-CoA dehydrogenase activity
B2B12_RS02650	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
B2B12_RS02655	COG0352	thiamine-phosphate diphosphorylase activity
B2B12_RS02660	COG0351	phosphomethylpyrimidine kinase
B2B12_RS02670	COG1678	Uncharacterized ACR, COG1678
B2B12_RS02675	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
B2B12_RS02700	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
B2B12_RS02710	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B2B12_RS02715	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
B2B12_RS02725	COG0557	exoribonuclease II activity
B2B12_RS02735	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
B2B12_RS02740	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B2B12_RS02745	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
B2B12_RS02755	COG0439	Biotin carboxylase
B2B12_RS02760	COG2264	protein methyltransferase activity
B2B12_RS02770	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B2B12_RS02795	COG1696	Membrane protein involved in D-alanine export
B2B12_RS02800	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B2B12_RS02840	COG1522	sequence-specific DNA binding
B2B12_RS02855	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B2B12_RS02920	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
B2B12_RS02945	COG3028	Belongs to the UPF0307 family
B2B12_RS02950	COG0312	modulator of DNA gyrase
B2B12_RS02955	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
B2B12_RS02960	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
B2B12_RS02965	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
B2B12_RS02975	COG0316	Belongs to the HesB IscA family
B2B12_RS02985	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
B2B12_RS02995	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
B2B12_RS03000	COG1881	PFAM PEBP family protein
B2B12_RS03005	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
B2B12_RS03010	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
B2B12_RS03025	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B2B12_RS03025	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B2B12_RS03040	COG2718	Belongs to the UPF0229 family
B2B12_RS03045	COG2719	SpoVR family
B2B12_RS03110	COG0165	Argininosuccinate lyase
B2B12_RS03115	COG0589	response to stress
B2B12_RS03125	COG2816	NAD+ diphosphatase activity
B2B12_RS03130	COG4993	Dehydrogenase
B2B12_RS03155	COG3181	Tripartite tricarboxylate transporter family receptor
B2B12_RS03160	COG2979	Protein of unknown function (DUF533)
B2B12_RS03165	COG4206	TonB-dependent receptor
B2B12_RS03180	COG0741	lytic transglycosylase activity
B2B12_RS03180	COG1388	LysM domain
B2B12_RS03185	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B2B12_RS03190	COG2226	methyltransferase
B2B12_RS03195	COG0328	RNA-DNA hybrid ribonuclease activity
B2B12_RS03220	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
B2B12_RS03240	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B2B12_RS03245	COG1129	ABC transporter
B2B12_RS03245	COG0842	Transport permease protein
B2B12_RS03250	COG0842	Transport permease protein
B2B12_RS03270	COG0463	Glycosyl transferase, family 2
B2B12_RS03275	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
B2B12_RS03290	COG1073	alpha beta
B2B12_RS03300	COG0697	spore germination
B2B12_RS03305	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B2B12_RS03330	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
B2B12_RS03360	COG0823	Involved in the tonB-independent uptake of proteins
B2B12_RS03370	COG0848	biopolymer transport protein
B2B12_RS03375	COG0811	peptide transport
B2B12_RS03380	COG0824	Thioesterase
B2B12_RS03385	COG0442	prolyl-tRNA aminoacylation
B2B12_RS03430	COG2084	Dehydrogenase
B2B12_RS03475	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
B2B12_RS03480	COG4654	Cytochrome c, class I
B2B12_RS03485	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B2B12_RS03550	COG1473	amidohydrolase
B2B12_RS03555	COG0418	dihydroorotase activity
B2B12_RS03560	COG0488	(ABC) transporter
B2B12_RS03570	COG2001	Belongs to the MraZ family
B2B12_RS03575	COG0275	rRNA processing
B2B12_RS03580	COG3116	cell division
B2B12_RS03590	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
B2B12_RS03595	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B2B12_RS03600	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
B2B12_RS03610	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B2B12_RS03615	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
B2B12_RS03620	COG1181	Belongs to the D-alanine--D-alanine ligase family
B2B12_RS03625	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
B2B12_RS03640	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
B2B12_RS03655	COG0739	heme binding
B2B12_RS03660	COG0653	protein targeting
B2B12_RS03685	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
B2B12_RS03690	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
B2B12_RS03700	COG0828	Belongs to the bacterial ribosomal protein bS21 family
B2B12_RS03750	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
B2B12_RS03765	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
B2B12_RS03790	COG0583	DNA-binding transcription factor activity
B2B12_RS03800	COG3181	Tripartite tricarboxylate transporter family receptor
B2B12_RS03805	COG2084	Dehydrogenase
B2B12_RS03815	COG1597	lipid kinase activity
B2B12_RS03815	COG1803	Methylglyoxal synthase
B2B12_RS03825	COG0671	phosphoesterase, PA-phosphatase related
B2B12_RS03845	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
B2B12_RS03850	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B2B12_RS03855	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B2B12_RS03860	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B2B12_RS03865	COG0649	NAD binding
B2B12_RS03870	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
B2B12_RS03880	COG1034	ATP synthesis coupled electron transport
B2B12_RS03885	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
B2B12_RS03890	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B2B12_RS03900	COG0713	ATP synthesis coupled electron transport
B2B12_RS03915	COG1007	ATP synthesis coupled electron transport
B2B12_RS03925	COG0560	Phosphoserine phosphatase
B2B12_RS03930	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
B2B12_RS03935	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
B2B12_RS03940	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
B2B12_RS03955	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B2B12_RS03960	COG0450	alkyl hydroperoxide reductase
B2B12_RS03980	COG1214	PFAM Peptidase M22, glycoprotease
B2B12_RS03985	COG1573	uracil-dna glycosylase
B2B12_RS03990	COG0477	Major facilitator Superfamily
B2B12_RS03995	COG1196	nuclear chromosome segregation
B2B12_RS04005	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
B2B12_RS04010	COG1126	abc transporter atp-binding protein
B2B12_RS04015	COG0765	amino acid transport
B2B12_RS04020	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B2B12_RS04025	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B2B12_RS04030	COG2917	probably involved in intracellular septation
B2B12_RS04035	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B2B12_RS04040	COG1122	ATPase activity
B2B12_RS04045	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
B2B12_RS04080	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B2B12_RS04115	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
B2B12_RS04120	COG2878	Part of a membrane complex involved in electron transport
B2B12_RS04140	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
B2B12_RS04145	COG0251	oxidation-reduction process
B2B12_RS04155	COG3228	Belongs to the MtfA family
B2B12_RS04160	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B2B12_RS04170	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B2B12_RS04180	COG0159	tryptophan synthase activity
B2B12_RS04185	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
B2B12_RS04190	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
B2B12_RS04205	COG1530	ribonuclease E activity
B2B12_RS04210	COG0564	pseudouridine synthase activity
B2B12_RS04215	COG0546	phosphoglycolate phosphatase activity
B2B12_RS04220	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
B2B12_RS04225	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
B2B12_RS04230	COG3023	N-Acetylmuramoyl-L-alanine amidase
B2B12_RS04240	COG0424	maF-like protein
B2B12_RS04250	COG0333	Belongs to the bacterial ribosomal protein bL32 family
B2B12_RS04260	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B2B12_RS04270	COG1028	Short-chain dehydrogenase reductase Sdr
B2B12_RS04275	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B2B12_RS04280	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B2B12_RS04305	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B2B12_RS04335	COG0481	GTPase activity
B2B12_RS04340	COG0681	Belongs to the peptidase S26 family
B2B12_RS04345	COG0571	ribonuclease III activity
B2B12_RS04350	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
B2B12_RS04355	COG1381	Involved in DNA repair and RecF pathway recombination
B2B12_RS04375	COG0670	Belongs to the BI1 family
B2B12_RS04390	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
B2B12_RS04415	COG0583	DNA-binding transcription factor activity
B2B12_RS04435	COG0791	NLP P60 protein
B2B12_RS04440	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B2B12_RS04445	COG3193	protein, possibly involved in utilization of glycolate and propanediol
B2B12_RS04455	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B2B12_RS04475	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
B2B12_RS04510	COG1446	asparaginase
B2B12_RS04515	COG4172	Belongs to the ABC transporter superfamily
B2B12_RS04520	COG0747	negative chemotaxis
B2B12_RS04525	COG0601	transmembrane transport
B2B12_RS04550	COG0504	CTP synthase activity
B2B12_RS04560	COG0148	phosphopyruvate hydratase activity
B2B12_RS04575	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
B2B12_RS04585	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B2B12_RS04590	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B2B12_RS04635	COG1981	membrane
B2B12_RS04655	COG0039	L-malate dehydrogenase activity
B2B12_RS04660	COG2188	Transcriptional regulator
B2B12_RS04665	COG2009	succinate dehydrogenase
B2B12_RS04670	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
B2B12_RS04675	COG1053	succinate dehydrogenase
B2B12_RS04680	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
B2B12_RS04685	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
B2B12_RS04690	COG0372	Belongs to the citrate synthase family
B2B12_RS04705	COG0583	DNA-binding transcription factor activity
B2B12_RS04710	COG3842	ATPase activity
B2B12_RS04720	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B2B12_RS04725	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B2B12_RS04735	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B2B12_RS04745	COG3128	pkhd-type hydroxylase
B2B12_RS04750	COG4774	siderophore transport
B2B12_RS04765	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
B2B12_RS04770	COG2894	cell division
B2B12_RS04775	COG0850	regulation of cytokinetic process
B2B12_RS04780	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B2B12_RS04790	COG1294	oxidase, subunit
B2B12_RS04810	COG0514	ATP-dependent DNA helicase (RecQ)
B2B12_RS04815	COG2255	four-way junction helicase activity
B2B12_RS04830	COG0632	four-way junction helicase activity
B2B12_RS04835	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
B2B12_RS04860	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B2B12_RS04870	COG0006	proline dipeptidase activity
B2B12_RS04915	COG0429	hydrolase of the alpha beta-hydrolase fold
B2B12_RS04940	COG0513	Belongs to the DEAD box helicase family
B2B12_RS04960	COG1414	Transcriptional regulator
B2B12_RS05010	COG0167	dihydroorotate dehydrogenase activity
B2B12_RS05015	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
B2B12_RS05020	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
B2B12_RS05030	COG0583	DNA-binding transcription factor activity
B2B12_RS05060	COG0523	cobalamin synthesis protein
B2B12_RS05065	COG1335	isochorismatase
B2B12_RS05070	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B2B12_RS05075	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
B2B12_RS05080	COG1802	Transcriptional regulator
B2B12_RS05085	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
B2B12_RS05090	COG1028	Short-chain dehydrogenase reductase Sdr
B2B12_RS05105	COG3181	Tripartite tricarboxylate transporter family receptor
B2B12_RS05110	COG1280	lysine exporter protein (LysE YggA)
B2B12_RS05115	COG2828	Protein conserved in bacteria
B2B12_RS05160	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B2B12_RS05165	COG0735	belongs to the Fur family
B2B12_RS05195	COG0497	DNA recombination
B2B12_RS05200	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
B2B12_RS05205	COG1420	regulation of RNA biosynthetic process
B2B12_RS05210	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
B2B12_RS05220	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
B2B12_RS05230	COG0443	Heat shock 70 kDa protein
B2B12_RS05240	COG0612	Peptidase, M16
B2B12_RS05260	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B2B12_RS05295	COG0745	RESPONSE REGULATOR receiver
B2B12_RS05305	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
B2B12_RS05310	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
B2B12_RS05315	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
B2B12_RS05330	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B2B12_RS05345	COG1193	negative regulation of DNA recombination
B2B12_RS05350	COG0492	ferredoxin-NADP+ reductase activity
B2B12_RS05355	COG1674	ftsk spoiiie
B2B12_RS05360	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
B2B12_RS05365	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
B2B12_RS05370	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
B2B12_RS05410	COG3468	outer membrane autotransporter barrel domain protein
B2B12_RS05430	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B2B12_RS05435	COG1024	Enoyl-CoA hydratase
B2B12_RS05460	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
B2B12_RS05465	COG0501	Belongs to the peptidase M48B family
B2B12_RS05475	COG0789	Transcriptional regulator
B2B12_RS05485	COG0165	Argininosuccinate lyase
B2B12_RS05490	COG0668	transmembrane transport
B2B12_RS05495	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
B2B12_RS05495	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B2B12_RS05525	COG0604	alcohol dehydrogenase
B2B12_RS05525	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B2B12_RS05525	COG3321	synthase
B2B12_RS05525	COG4221	oxidoreductase activity
B2B12_RS05530	COG0149	triose-phosphate isomerase activity
B2B12_RS05540	COG0438	transferase activity, transferring glycosyl groups
B2B12_RS05545	COG4607	ABC-type enterochelin transport system periplasmic component
B2B12_RS05550	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B2B12_RS05555	COG4605	iron ion homeostasis
B2B12_RS05560	COG4604	ABC transporter, ATP-binding protein
B2B12_RS05580	COG0179	Fumarylacetoacetate (FAA) hydrolase
B2B12_RS05595	COG1028	Short-chain dehydrogenase reductase Sdr
B2B12_RS05630	COG1595	DNA-templated transcription, initiation
B2B12_RS05655	COG2186	Transcriptional regulator
B2B12_RS05660	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B2B12_RS05665	COG1960	acyl-CoA dehydrogenase activity
B2B12_RS05685	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
B2B12_RS05690	COG2199	diguanylate cyclase activity
B2B12_RS05690	COG2202	Pas domain
B2B12_RS05690	COG2200	EAL domain
B2B12_RS05765	COG2271	Major facilitator Superfamily
B2B12_RS05785	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B2B12_RS05795	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B2B12_RS05815	COG2321	neutral zinc metallopeptidase
B2B12_RS05820	COG0009	L-threonylcarbamoyladenylate synthase
B2B12_RS05825	COG1994	Peptidase M50
B2B12_RS05830	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B2B12_RS05835	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
B2B12_RS05845	COG2850	peptidyl-arginine hydroxylation
B2B12_RS05850	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
B2B12_RS05870	COG3360	Dodecin
B2B12_RS05890	COG1802	Transcriptional regulator
B2B12_RS05905	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
B2B12_RS05915	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
B2B12_RS05940	COG0668	transmembrane transport
B2B12_RS05960	COG0483	inositol monophosphate 1-phosphatase activity
B2B12_RS05965	COG1253	flavin adenine dinucleotide binding
B2B12_RS05970	COG1968	undecaprenyl-diphosphatase activity
B2B12_RS05975	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B2B12_RS05980	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
B2B12_RS05990	COG0215	cysteine-tRNA ligase activity
B2B12_RS06000	COG0825	malonyl-CoA metabolic process
B2B12_RS06005	COG0037	tRNA processing
B2B12_RS06025	COG2814	Major facilitator Superfamily
B2B12_RS06030	COG4772	TonB-dependent receptor
B2B12_RS06040	COG4993	Dehydrogenase
B2B12_RS06055	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B2B12_RS06060	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B2B12_RS06065	COG1121	(ABC) transporter
B2B12_RS06070	COG0803	Belongs to the bacterial solute-binding protein 9 family
B2B12_RS06085	COG0500	methyltransferase
B2B12_RS06110	COG2204	response regulator
B2B12_RS06115	COG4191	Histidine kinase
B2B12_RS06125	COG0424	maF-like protein
B2B12_RS06130	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
B2B12_RS06135	COG0799	negative regulation of ribosome biogenesis
B2B12_RS06140	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
B2B12_RS06150	COG0151	Belongs to the GarS family
B2B12_RS06155	COG0217	transcriptional regulatory protein
B2B12_RS06160	COG0433	COG0433 Predicted ATPase
B2B12_RS06165	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B2B12_RS06170	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B2B12_RS06195	COG2814	Major facilitator Superfamily
B2B12_RS06200	COG1566	PFAM secretion protein HlyD family protein
B2B12_RS06210	COG1846	Transcriptional regulator
B2B12_RS06240	COG1530	ribonuclease E activity
B2B12_RS06300	COG2433	Pfam Transposase IS66
B2B12_RS06330	COG1278	Cold shock
B2B12_RS06340	COG2801	Transposase and inactivated derivatives
B2B12_RS06385	COG0544	peptidyl-prolyl cis-trans isomerase activity
B2B12_RS06390	COG0740	serine-type endopeptidase activity
B2B12_RS06400	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
B2B12_RS06415	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
B2B12_RS06455	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B2B12_RS06475	COG0583	DNA-binding transcription factor activity
B2B12_RS06490	COG0556	nucleotide-excision repair
B2B12_RS06495	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B2B12_RS06505	COG1104	cysteine desulfurase activity
B2B12_RS06510	COG0822	iron-sulfur transferase activity
B2B12_RS06515	COG0316	Belongs to the HesB IscA family
B2B12_RS06520	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
B2B12_RS06525	COG0443	Heat shock 70 kDa protein
B2B12_RS06530	COG0633	Ferredoxin
B2B12_RS06535	COG2975	iron-sulfur cluster assembly
B2B12_RS06560	COG2801	Transposase and inactivated derivatives
B2B12_RS06565	COG2801	Transposase and inactivated derivatives
B2B12_RS06585	COG1803	Methylglyoxal synthase
B2B12_RS06595	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
B2B12_RS06600	COG1028	Short-chain dehydrogenase reductase Sdr
B2B12_RS06610	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
B2B12_RS06625	COG1136	(ABC) transporter
B2B12_RS06630	COG0084	hydrolase, TatD family'
B2B12_RS06640	COG3712	iron ion homeostasis
B2B12_RS06645	COG1595	DNA-templated transcription, initiation
B2B12_RS06680	COG3181	Tripartite tricarboxylate transporter family receptor
B2B12_RS06690	COG3181	Tripartite tricarboxylate transporter family receptor
B2B12_RS06700	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B2B12_RS06720	COG0583	DNA-binding transcription factor activity
B2B12_RS06730	COG1012	belongs to the aldehyde dehydrogenase family
B2B12_RS06790	COG0613	PHP domain protein
B2B12_RS06800	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
B2B12_RS06805	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
B2B12_RS06805	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
B2B12_RS06825	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
B2B12_RS06830	COG0047	phosphoribosylformylglycinamidine synthase activity
B2B12_RS06830	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B2B12_RS06870	COG0747	negative chemotaxis
B2B12_RS06875	COG4608	Belongs to the ABC transporter superfamily
B2B12_RS06885	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B2B12_RS06905	COG0601	transmembrane transport
B2B12_RS06910	COG2072	flavoprotein involved in K transport
B2B12_RS06925	COG1695	Transcriptional regulator
B2B12_RS06940	COG0519	Catalyzes the synthesis of GMP from XMP
B2B12_RS06940	COG0518	GMP synthase (glutamine-hydrolyzing) activity
B2B12_RS06950	COG3177	Filamentation induced by cAMP protein fic
B2B12_RS06985	COG1733	regulation of RNA biosynthetic process
B2B12_RS06990	COG0384	phenazine biosynthesis protein PhzF
B2B12_RS07015	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
B2B12_RS07035	COG0583	DNA-binding transcription factor activity
B2B12_RS07070	COG1012	belongs to the aldehyde dehydrogenase family
B2B12_RS07085	COG2814	Major facilitator Superfamily
B2B12_RS07090	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
B2B12_RS07095	COG2207	Transcriptional regulator
B2B12_RS07100	COG2807	transmembrane transport
B2B12_RS07125	COG2814	Major facilitator Superfamily
B2B12_RS07130	COG0583	DNA-binding transcription factor activity
B2B12_RS07155	COG1396	sequence-specific DNA binding
B2B12_RS07190	COG5507	3-demethylubiquinone-9 3-methyltransferase
B2B12_RS07215	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
B2B12_RS07270	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
B2B12_RS07275	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
B2B12_RS07280	COG0390	transport system, permease component
B2B12_RS07290	COG0587	DNA-directed DNA polymerase activity
B2B12_RS07325	COG0720	synthase
B2B12_RS07330	COG0602	queuosine metabolic process
B2B12_RS07365	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
B2B12_RS07375	COG0842	Transport permease protein
B2B12_RS07380	COG1131	(ABC) transporter
B2B12_RS07390	COG1309	transcriptional regulator
B2B12_RS07395	COG2130	NADP-dependent
B2B12_RS07405	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
B2B12_RS07415	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
B2B12_RS07450	COG0420	3'-5' exonuclease activity
B2B12_RS07475	COG3181	Tripartite tricarboxylate transporter family receptor
B2B12_RS07480	COG2111	Na H antiporter
B2B12_RS07480	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
B2B12_RS07485	COG1006	Multisubunit Na H antiporter MnhC subunit
B2B12_RS07490	COG0651	ATP synthesis coupled electron transport
B2B12_RS07495	COG1863	multisubunit Na H antiporter MnhE subunit
B2B12_RS07500	COG2212	antiporter activity
B2B12_RS07505	COG1320	monovalent cation:proton antiporter activity
B2B12_RS07520	COG0590	tRNA wobble adenosine to inosine editing
B2B12_RS07525	COG1619	proteins homologs of microcin C7 resistance protein MccF
B2B12_RS07530	COG0488	(ABC) transporter
B2B12_RS07565	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B2B12_RS07570	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B2B12_RS07575	COG2252	PERMEase
B2B12_RS07580	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
B2B12_RS07585	COG0583	DNA-binding transcription factor activity
B2B12_RS07610	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
B2B12_RS07620	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
B2B12_RS07655	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B2B12_RS07660	COG0789	Transcriptional regulator
B2B12_RS07665	COG2217	Heavy metal translocating P-type atpase
B2B12_RS07675	COG0678	peroxiredoxin activity
B2B12_RS07675	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
B2B12_RS07685	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
B2B12_RS07690	COG0584	glycerophosphoryl diester phosphodiesterase
B2B12_RS07695	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B2B12_RS07705	COG4181	ATPase activity
B2B12_RS07715	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
B2B12_RS07715	COG3210	domain, Protein
B2B12_RS07715	COG3064	Membrane
B2B12_RS07735	COG3121	Chaperone
B2B12_RS07740	COG3188	usher protein
B2B12_RS07750	COG2831	hemolysin activation secretion protein
B2B12_RS07760	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B2B12_RS07765	COG0765	amino acid transport
B2B12_RS07770	COG1126	abc transporter atp-binding protein
B2B12_RS07775	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B2B12_RS07780	COG1758	RNA polymerase activity
B2B12_RS07785	COG0194	GDP metabolic process
B2B12_RS07790	COG1028	Short-chain dehydrogenase reductase Sdr
B2B12_RS07795	COG0791	NLP P60 protein
B2B12_RS07800	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
B2B12_RS07810	COG1561	YicC-like family, N-terminal region
B2B12_RS07815	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
B2B12_RS07825	COG2079	MmgE PrpD family protein
B2B12_RS07830	COG1960	acyl-CoA dehydrogenase activity
B2B12_RS07835	COG0583	DNA-binding transcription factor activity
B2B12_RS07850	COG0840	transmembrane signaling receptor activity
B2B12_RS07860	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
B2B12_RS07865	COG0635	Involved in the biosynthesis of porphyrin-containing compound
B2B12_RS07870	COG0174	glutamine synthetase
B2B12_RS07885	COG0583	DNA-binding transcription factor activity
B2B12_RS07890	COG1741	Belongs to the pirin family
B2B12_RS07895	COG1741	Belongs to the pirin family
B2B12_RS07900	COG3842	ATPase activity
B2B12_RS07910	COG1840	ABC-type Fe3 transport system, periplasmic component
B2B12_RS07940	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
B2B12_RS07945	COG0583	DNA-binding transcription factor activity
B2B12_RS07950	COG0783	Belongs to the Dps family
B2B12_RS07965	COG0463	Glycosyl transferase, family 2
B2B12_RS07990	COG0438	transferase activity, transferring glycosyl groups
B2B12_RS08005	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
B2B12_RS08030	COG3842	ATPase activity
B2B12_RS08035	COG0395	ABC-type sugar transport system, permease component
B2B12_RS08040	COG1175	transmembrane transport
B2B12_RS08055	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
B2B12_RS08065	COG0559	Belongs to the binding-protein-dependent transport system permease family
B2B12_RS08085	COG1794	racemase activity, acting on amino acids and derivatives
B2B12_RS08095	COG0625	glutathione transferase activity
B2B12_RS08100	COG2133	pyrroloquinoline quinone binding
B2B12_RS08105	COG0697	spore germination
B2B12_RS08125	COG1464	Belongs to the NlpA lipoprotein family
B2B12_RS08130	COG1304	FMN binding
B2B12_RS08135	COG0688	phosphatidylethanolamine metabolic process
B2B12_RS08145	COG1012	belongs to the aldehyde dehydrogenase family
B2B12_RS08155	COG0028	Belongs to the TPP enzyme family
B2B12_RS08165	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
B2B12_RS08165	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
B2B12_RS08175	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
B2B12_RS08185	COG3189	MarR family transcriptional regulator
B2B12_RS08190	COG2985	domain, Protein
B2B12_RS08195	COG0076	glutamate decarboxylase activity
B2B12_RS08220	COG2205	protein histidine kinase activity
B2B12_RS08220	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B2B12_RS08225	COG2197	response regulator
B2B12_RS08230	COG5001	Diguanylate cyclase
B2B12_RS08230	COG3706	GGDEF domain
B2B12_RS08230	COG2203	Gaf domain
B2B12_RS08230	COG4251	negative regulation of phosphorylation
B2B12_RS08235	COG1253	flavin adenine dinucleotide binding
B2B12_RS08255	COG2200	EAL domain
B2B12_RS08300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B2B12_RS08305	COG0765	amino acid transport
B2B12_RS08310	COG1126	abc transporter atp-binding protein
B2B12_RS08335	COG1619	proteins homologs of microcin C7 resistance protein MccF
B2B12_RS08345	COG2203	Gaf domain
B2B12_RS08345	COG2199	diguanylate cyclase activity
B2B12_RS08380	COG1191	sigma factor activity
B2B12_RS08400	COG0840	transmembrane signaling receptor activity
B2B12_RS08405	COG0840	transmembrane signaling receptor activity
B2B12_RS08430	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
B2B12_RS08440	COG1580	Controls the rotational direction of flagella during chemotaxis
B2B12_RS08460	COG1317	bacterial-type flagellum organization
B2B12_RS08465	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
B2B12_RS08475	COG1677	Flagellar hook-basal body complex protein FliE
B2B12_RS08485	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
B2B12_RS08525	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B2B12_RS08530	COG3181	Tripartite tricarboxylate transporter family receptor
B2B12_RS08540	COG0285	dihydrofolate synthase activity
B2B12_RS08550	COG1286	toxin biosynthetic process
B2B12_RS08570	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
B2B12_RS08575	COG0024	Methionine aminopeptidase
B2B12_RS08580	COG0052	Belongs to the universal ribosomal protein uS2 family
B2B12_RS08585	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
B2B12_RS08590	COG0528	UMP kinase activity
B2B12_RS08595	COG0233	cytoplasmic translational termination
B2B12_RS08600	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
B2B12_RS08610	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
B2B12_RS08615	COG0750	zinc metalloprotease
B2B12_RS08620	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B2B12_RS08630	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B2B12_RS08635	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
B2B12_RS08645	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B2B12_RS08650	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
B2B12_RS08655	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B2B12_RS08665	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
B2B12_RS08675	COG0518	GMP synthase (glutamine-hydrolyzing) activity
B2B12_RS08675	COG0519	Catalyzes the synthesis of GMP from XMP
B2B12_RS08715	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
B2B12_RS08725	COG2914	Belongs to the UPF0125 (RnfH) family
B2B12_RS08735	COG1960	acyl-CoA dehydrogenase activity
B2B12_RS08740	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
B2B12_RS08765	COG0583	DNA-binding transcription factor activity
B2B12_RS08770	COG2175	clavaminate synthase activity
B2B12_RS08780	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
B2B12_RS08785	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
B2B12_RS08795	COG0084	hydrolase, TatD family'
B2B12_RS08810	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B2B12_RS08815	COG0765	amino acid transport
B2B12_RS08825	COG0010	Belongs to the arginase family
B2B12_RS08835	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
B2B12_RS08845	COG0095	Lipoate-protein ligase
B2B12_RS08860	COG0386	Belongs to the glutathione peroxidase family
B2B12_RS08880	COG0415	Belongs to the DNA photolyase family
B2B12_RS08910	COG2259	Doxx family
B2B12_RS08920	COG1028	Short-chain dehydrogenase reductase Sdr
B2B12_RS08930	COG0842	Transport permease protein
B2B12_RS08935	COG1129	ABC transporter
B2B12_RS08935	COG0842	Transport permease protein
B2B12_RS08940	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B2B12_RS08960	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
B2B12_RS08980	COG2733	membrane
B2B12_RS09015	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B2B12_RS09045	COG2814	Major facilitator Superfamily
B2B12_RS09075	COG3486	L-lysine 6-monooxygenase (NADPH) activity
B2B12_RS09090	COG1028	Short-chain dehydrogenase reductase Sdr
B2B12_RS09100	COG3022	response to hydroperoxide
B2B12_RS09125	COG0028	Belongs to the TPP enzyme family
B2B12_RS09130	COG0440	acetolactate synthase activity
B2B12_RS09140	COG1183	phosphatidylcholine synthase activity
B2B12_RS09155	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
B2B12_RS09160	COG1185	polyribonucleotide nucleotidyltransferase activity
B2B12_RS09190	COG0583	DNA-binding transcription factor activity
B2B12_RS09205	COG1129	ABC transporter
B2B12_RS09240	COG1280	lysine exporter protein (LysE YggA)
B2B12_RS09255	COG3161	chorismate lyase activity
B2B12_RS09260	COG1187	pseudouridine synthase activity
B2B12_RS09265	COG0583	DNA-binding transcription factor activity
B2B12_RS09270	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B2B12_RS09290	COG1999	signal sequence binding
B2B12_RS09310	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
B2B12_RS09315	COG4566	intracellular signal transduction
B2B12_RS09325	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
B2B12_RS09330	COG0508	dehydrogenase complex catalyzes the overall conversion of
B2B12_RS09335	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B2B12_RS09345	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
B2B12_RS09350	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B2B12_RS09360	COG1028	Short-chain dehydrogenase reductase Sdr
B2B12_RS09365	COG0583	DNA-binding transcription factor activity
B2B12_RS09370	COG0257	Belongs to the bacterial ribosomal protein bL36 family
B2B12_RS09395	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B2B12_RS09415	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B2B12_RS09430	COG2900	Belongs to the SlyX family
B2B12_RS09435	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B2B12_RS09460	COG2814	Major facilitator Superfamily
B2B12_RS09505	COG2801	Transposase and inactivated derivatives
B2B12_RS09560	COG2171	N-acyltransferase activity
B2B12_RS09565	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B2B12_RS09570	COG2890	protein-(glutamine-N5) methyltransferase activity
B2B12_RS09575	COG0488	(ABC) transporter
B2B12_RS09580	COG4771	TonB-dependent receptor
B2B12_RS09585	COG0210	DNA helicase
B2B12_RS09620	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
B2B12_RS09620	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B2B12_RS09630	COG0196	riboflavin kinase activity
B2B12_RS09635	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
B2B12_RS09640	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
B2B12_RS09645	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
B2B12_RS09665	COG1522	sequence-specific DNA binding
B2B12_RS09695	COG0756	dUTP diphosphatase activity
B2B12_RS09705	COG0765	amino acid transport
B2B12_RS09710	COG0765	amino acid transport
B2B12_RS09715	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B2B12_RS09730	COG1764	response to oxidative stress
B2B12_RS09740	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B2B12_RS09745	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
B2B12_RS09760	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
B2B12_RS09765	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
B2B12_RS09770	COG2197	response regulator
B2B12_RS09775	COG0635	Involved in the biosynthesis of porphyrin-containing compound
B2B12_RS09810	COG2801	Transposase and inactivated derivatives
B2B12_RS09815	COG2801	Transposase and inactivated derivatives
B2B12_RS09835	COG0135	phosphoribosylanthranilate isomerase activity
B2B12_RS09840	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
B2B12_RS09845	COG0101	tRNA pseudouridine synthase activity
B2B12_RS09855	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
B2B12_RS09860	COG0473	3-isopropylmalate dehydrogenase activity
B2B12_RS09875	COG0066	3-isopropylmalate dehydratase activity
B2B12_RS09900	COG2197	response regulator
B2B12_RS09905	COG0501	Belongs to the peptidase M48B family
B2B12_RS09910	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
B2B12_RS09930	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
B2B12_RS09940	COG1295	ribonuclease BN
B2B12_RS09950	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B2B12_RS09995	COG1450	Type ii and iii secretion system protein
B2B12_RS10040	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
B2B12_RS10080	COG0181	hydroxymethylbilane synthase activity
B2B12_RS10085	COG0861	Integral membrane protein TerC family
B2B12_RS10090	COG0861	Integral membrane protein TerC family
B2B12_RS10095	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
B2B12_RS10100	COG0045	succinate-CoA ligase (ADP-forming) activity
B2B12_RS10120	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
B2B12_RS10130	COG2137	regulation of response to DNA damage stimulus
B2B12_RS10135	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
B2B12_RS10160	COG2974	May be involved in recombination
B2B12_RS10165	COG0540	Belongs to the ATCase OTCase family
B2B12_RS10195	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B2B12_RS10255	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
B2B12_RS10275	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
B2B12_RS10290	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B2B12_RS10300	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B2B12_RS10305	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
B2B12_RS10315	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B2B12_RS10330	COG3620	sequence-specific DNA binding
B2B12_RS10335	COG2233	PERMEase
B2B12_RS10365	COG0406	alpha-ribazole phosphatase activity
B2B12_RS10370	COG1028	Short-chain dehydrogenase reductase Sdr
B2B12_RS10380	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B2B12_RS10385	COG0505	Belongs to the CarA family
B2B12_RS10390	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
B2B12_RS10395	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B2B12_RS10415	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
B2B12_RS10420	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
B2B12_RS10425	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
B2B12_RS10455	COG1686	Belongs to the peptidase S11 family
B2B12_RS10460	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
B2B12_RS10465	COG4974	Belongs to the 'phage' integrase family
B2B12_RS10470	COG0583	DNA-binding transcription factor activity
B2B12_RS10475	COG0028	Belongs to the TPP enzyme family
B2B12_RS10480	COG1960	acyl-CoA dehydrogenase activity
B2B12_RS10510	COG4771	TonB-dependent receptor
B2B12_RS10520	COG0009	L-threonylcarbamoyladenylate synthase
B2B12_RS10525	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
B2B12_RS10530	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
B2B12_RS10535	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
B2B12_RS10545	COG1301	dicarboxylic acid transport
B2B12_RS10550	COG0456	acetyltransferase
B2B12_RS10590	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
B2B12_RS10600	COG0739	heme binding
B2B12_RS10610	COG0521	Mo-molybdopterin cofactor biosynthetic process
B2B12_RS10615	COG0306	phosphate transporter
B2B12_RS10630	COG0789	Transcriptional regulator
B2B12_RS10650	COG0625	glutathione transferase activity
B2B12_RS10665	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
B2B12_RS10685	COG0126	phosphoglycerate kinase activity
B2B12_RS10690	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
B2B12_RS10695	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
B2B12_RS10700	COG1385	rRNA (uridine-N3-)-methyltransferase activity
B2B12_RS10715	COG0281	malic enzyme
B2B12_RS10715	COG0280	phosphate acetyltransferase
B2B12_RS10725	COG0436	Aminotransferase
B2B12_RS10730	COG0741	lytic transglycosylase activity
B2B12_RS10735	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
B2B12_RS10760	COG4575	ribosome binding
B2B12_RS10770	COG1648	precorrin-2 dehydrogenase activity
B2B12_RS10770	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
B2B12_RS10775	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
B2B12_RS10780	COG2027	D-alanyl-D-alanine carboxypeptidase
B2B12_RS10785	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
B2B12_RS10790	COG0343	queuine tRNA-ribosyltransferase activity
B2B12_RS10795	COG1862	Preprotein translocase
B2B12_RS10800	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B2B12_RS10805	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B2B12_RS10825	COG0667	Aldo Keto reductase
B2B12_RS10830	COG0815	Transfers the fatty acyl group on membrane lipoproteins
B2B12_RS10835	COG4535	Mg2 and Co2 transporter CorC
B2B12_RS10840	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
B2B12_RS10845	COG1702	phosphate starvation-inducible protein PhoH
B2B12_RS10850	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B2B12_RS10875	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
B2B12_RS10880	COG0697	spore germination
B2B12_RS10890	COG0494	nUDIX hydrolase
B2B12_RS10905	COG3530	Putative quorum-sensing-regulated virulence factor
B2B12_RS10915	COG3015	lipoprotein NlpE involved in copper resistance
B2B12_RS10935	COG2814	Major facilitator Superfamily
B2B12_RS10945	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
B2B12_RS10970	COG0628	permease
B2B12_RS10980	COG1131	(ABC) transporter
B2B12_RS10985	COG1764	response to oxidative stress
B2B12_RS10990	COG1846	Transcriptional regulator
B2B12_RS10995	COG2224	Isocitrate lyase
B2B12_RS11000	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
B2B12_RS11000	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
B2B12_RS11010	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
B2B12_RS11015	COG0322	excinuclease ABC activity
B2B12_RS11020	COG1472	Belongs to the glycosyl hydrolase 3 family
B2B12_RS11025	COG0736	holo-[acyl-carrier-protein] synthase activity
B2B12_RS11030	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
B2B12_RS11040	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B2B12_RS11045	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B2B12_RS11050	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B2B12_RS11080	COG4149	molybdate abc transporter
B2B12_RS11085	COG0725	ABC transporter, periplasmic molybdate-binding protein
B2B12_RS11090	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
B2B12_RS11095	COG4120	Belongs to the binding-protein-dependent transport system permease family
B2B12_RS11110	COG2032	superoxide dismutase activity
B2B12_RS11120	COG0318	PFAM AMP-dependent synthetase and ligase
B2B12_RS11125	COG1024	Enoyl-CoA hydratase
B2B12_RS11135	COG1802	Transcriptional regulator
B2B12_RS11150	COG1217	gtp-binding protein TYPA
B2B12_RS11155	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
B2B12_RS11160	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
B2B12_RS11165	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
B2B12_RS11170	COG0195	Participates in both transcription termination and antitermination
B2B12_RS11170	COG2251	uridine kinase activity
B2B12_RS11175	COG0779	Required for maturation of 30S ribosomal subunits
B2B12_RS11180	COG1187	pseudouridine synthase activity
B2B12_RS11185	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
B2B12_RS11195	COG0583	DNA-binding transcription factor activity
B2B12_RS11205	COG0523	cobalamin synthesis protein
B2B12_RS11225	COG0625	glutathione transferase activity
B2B12_RS11230	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
B2B12_RS11240	COG2003	Belongs to the UPF0758 family
B2B12_RS11245	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
B2B12_RS11250	COG3483	tryptophan 2,3-dioxygenase activity
B2B12_RS11255	COG0254	rRNA binding
B2B12_RS11295	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
B2B12_RS11300	COG1562	ergosterol biosynthetic process
B2B12_RS11305	COG1562	ergosterol biosynthetic process
B2B12_RS11310	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
B2B12_RS11310	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
B2B12_RS11315	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
B2B12_RS11340	COG1477	protein flavinylation
B2B12_RS11355	COG0542	response to heat
B2B12_RS11365	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B2B12_RS11380	COG0678	peroxiredoxin activity
B2B12_RS11390	COG0412	Dienelactone hydrolase
B2B12_RS11395	COG0315	cyclic pyranopterin monophosphate synthase activity
B2B12_RS11405	COG0314	molybdopterin synthase activity
B2B12_RS11410	COG0521	Mo-molybdopterin cofactor biosynthetic process
B2B12_RS11415	COG0303	'Molybdopterin
B2B12_RS11420	COG0746	molybdenum cofactor guanylyltransferase activity
B2B12_RS11425	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
B2B12_RS11460	COG2264	protein methyltransferase activity
B2B12_RS11485	COG5006	permease, DMT superfamily
B2B12_RS11490	COG1028	Short-chain dehydrogenase reductase Sdr
B2B12_RS11515	COG1666	GTP binding
B2B12_RS11560	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
B2B12_RS11565	COG1845	cytochrome c oxidase, subunit III
B2B12_RS11570	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
B2B12_RS11580	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
B2B12_RS11600	COG0783	Belongs to the Dps family
B2B12_RS11605	COG1028	Short-chain dehydrogenase reductase Sdr
B2B12_RS11615	COG1346	cytolysis
B2B12_RS11635	COG4172	Belongs to the ABC transporter superfamily
B2B12_RS11640	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B2B12_RS11645	COG0601	transmembrane transport
B2B12_RS11650	COG0747	negative chemotaxis
B2B12_RS11660	COG0598	Magnesium transport protein CorA
B2B12_RS11665	COG0210	DNA helicase
B2B12_RS11680	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
B2B12_RS11685	COG1012	belongs to the aldehyde dehydrogenase family
B2B12_RS11690	COG0483	inositol monophosphate 1-phosphatase activity
B2B12_RS11695	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
B2B12_RS11705	COG1045	serine acetyltransferase
B2B12_RS11715	COG1960	acyl-CoA dehydrogenase activity
B2B12_RS11720	COG0183	Belongs to the thiolase family
B2B12_RS11725	COG1024	Enoyl-CoA hydratase
B2B12_RS11725	COG1250	3-hydroxyacyl-CoA dehydrogenase
B2B12_RS11735	COG1024	Enoyl-CoA hydratase
B2B12_RS11735	COG1250	3-hydroxyacyl-CoA dehydrogenase
B2B12_RS11740	COG0183	Belongs to the thiolase family
B2B12_RS11755	COG0318	PFAM AMP-dependent synthetase and ligase
B2B12_RS11775	COG3246	L-lysine catabolic process to acetate
B2B12_RS11780	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B2B12_RS11795	COG1610	YqeY-like protein
B2B12_RS11840	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
B2B12_RS11855	COG0667	Aldo Keto reductase
B2B12_RS11860	COG0656	L-ascorbic acid biosynthetic process
B2B12_RS11880	COG5265	(ABC) transporter
B2B12_RS11930	COG1522	sequence-specific DNA binding
B2B12_RS11950	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
B2B12_RS11960	COG1278	Cold shock
B2B12_RS11980	COG3181	Tripartite tricarboxylate transporter family receptor
B2B12_RS11985	COG1802	Transcriptional regulator
B2B12_RS12020	COG0776	regulation of translation
B2B12_RS12025	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B2B12_RS12025	COG0072	phenylalanine-tRNA ligase activity
B2B12_RS12030	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
B2B12_RS12035	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
B2B12_RS12040	COG0291	Belongs to the bacterial ribosomal protein bL35 family
B2B12_RS12090	COG0347	Belongs to the P(II) protein family
B2B12_RS12095	COG0004	ammonium transporteR
B2B12_RS12125	COG0506	proline dehydrogenase activity
B2B12_RS12125	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
B2B12_RS12125	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
B2B12_RS12135	COG3008	intermembrane lipid transfer
B2B12_RS12150	COG4953	penicillin-binding protein 1C
B2B12_RS12160	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
B2B12_RS12165	COG1278	Cold shock
B2B12_RS12175	COG0183	Belongs to the thiolase family
B2B12_RS12180	COG0038	chloride channel
B2B12_RS12190	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
B2B12_RS12195	COG1570	exodeoxyribonuclease VII activity
B2B12_RS12200	COG0811	peptide transport
B2B12_RS12205	COG0848	biopolymer transport protein
B2B12_RS12210	COG1663	tetraacyldisaccharide 4'-kinase activity
B2B12_RS12215	COG2835	tetraacyldisaccharide 4'-kinase activity
B2B12_RS12220	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
B2B12_RS12225	COG0563	adenylate kinase activity
B2B12_RS12235	COG0728	peptidoglycan biosynthetic process
B2B12_RS12285	COG0268	Binds directly to 16S ribosomal RNA
B2B12_RS12290	COG3836	Belongs to the HpcH HpaI aldolase family
B2B12_RS12325	COG2186	Transcriptional regulator
B2B12_RS12340	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B2B12_RS12350	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B2B12_RS12355	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
B2B12_RS12360	COG0137	argininosuccinate synthase activity
B2B12_RS12385	COG3158	transport of potassium into the cell
B2B12_RS12390	COG0642	Histidine kinase
B2B12_RS12420	COG0776	regulation of translation
B2B12_RS12425	COG2873	o-acetylhomoserine
B2B12_RS12430	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B2B12_RS12435	COG0557	exoribonuclease II activity
B2B12_RS12455	COG2153	protein acetylation
B2B12_RS12460	COG0679	Auxin Efflux Carrier
B2B12_RS12465	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
B2B12_RS12470	COG2391	methyltransferase activity
B2B12_RS12475	COG0069	glutamate synthase activity
B2B12_RS12500	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
B2B12_RS12520	COG2826	transposase and inactivated derivatives, IS30 family
B2B12_RS12535	COG3706	GGDEF domain
B2B12_RS12570	COG3909	cytochrome
B2B12_RS12575	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
B2B12_RS12580	COG0625	glutathione transferase activity
B2B12_RS12585	COG0730	response to heat
B2B12_RS12590	COG0482	sulfurtransferase activity
B2B12_RS12595	COG0583	DNA-binding transcription factor activity
B2B12_RS12635	COG0247	lactate metabolic process
B2B12_RS12640	COG0277	FAD linked oxidase domain protein
B2B12_RS12645	COG0277	FAD linked oxidase domain protein
B2B12_RS12670	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
B2B12_RS12675	COG0312	modulator of DNA gyrase
B2B12_RS12690	COG0308	aminopeptidase N
B2B12_RS12695	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
B2B12_RS12720	COG0436	Aminotransferase
B2B12_RS12725	COG3737	Protein of unknown function (DUF498/DUF598)
B2B12_RS12730	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
B2B12_RS12735	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
B2B12_RS12740	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
B2B12_RS12750	COG0305	Participates in initiation and elongation during chromosome replication
B2B12_RS12760	COG0359	binds to the 23S rRNA
B2B12_RS12765	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
B2B12_RS12770	COG2965	DNA replication, synthesis of RNA primer
B2B12_RS12775	COG0360	Binds together with S18 to 16S ribosomal RNA
B2B12_RS12780	COG1469	GTP cyclohydrolase I activity
B2B12_RS12785	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
B2B12_RS12790	COG0142	geranyltranstransferase activity
B2B12_RS12795	COG1722	exodeoxyribonuclease VII activity
B2B12_RS12845	COG0501	Belongs to the peptidase M48B family
B2B12_RS12865	COG1132	(ABC) transporter
B2B12_RS12900	COG0463	Glycosyl transferase, family 2
B2B12_RS12905	COG0726	polysaccharide deacetylase
B2B12_RS12910	COG0438	transferase activity, transferring glycosyl groups
B2B12_RS12925	COG1643	Atp-dependent helicase
B2B12_RS12930	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
B2B12_RS12930	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
B2B12_RS12935	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
B2B12_RS12940	COG0704	Plays a role in the regulation of phosphate uptake
B2B12_RS12945	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
B2B12_RS12955	COG1322	Protein conserved in bacteria
B2B12_RS12975	COG1177	transmembrane transport
B2B12_RS12980	COG1176	ABC-type spermidine putrescine transport system, permease component I
B2B12_RS12985	COG3842	ATPase activity
B2B12_RS12995	COG3642	lipopolysaccharide core region biosynthetic process
B2B12_RS13000	COG2346	COG2346, Truncated hemoglobins
B2B12_RS13005	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
B2B12_RS13010	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
B2B12_RS13020	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
B2B12_RS13020	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
B2B12_RS13055	COG2050	protein possibly involved in aromatic compounds catabolism
B2B12_RS13060	COG1024	Enoyl-CoA hydratase
B2B12_RS13065	COG1012	belongs to the aldehyde dehydrogenase family
B2B12_RS13070	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
B2B12_RS13075	COG2151	metal-sulfur cluster biosynthetic enzyme
B2B12_RS13080	COG3396	Phenylacetate-CoA oxygenase
B2B12_RS13085	COG3460	Phenylacetate-CoA oxygenase
B2B12_RS13090	COG3396	Phenylacetate-CoA oxygenase
B2B12_RS13095	COG3327	negative regulation of DNA-templated transcription, initiation
B2B12_RS13100	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
B2B12_RS13105	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
B2B12_RS13110	COG0501	Belongs to the peptidase M48B family
B2B12_RS13115	COG1162	GTPase activity
B2B12_RS13120	COG3622	Belongs to the hyi family
B2B12_RS13140	COG0335	large ribosomal subunit rRNA binding
B2B12_RS13170	COG0175	sulfate reduction
B2B12_RS13175	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
B2B12_RS13180	COG4208	sulfate ABC transporter
B2B12_RS13185	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
B2B12_RS13190	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
B2B12_RS13195	COG0450	alkyl hydroperoxide reductase
B2B12_RS13200	COG1960	acyl-CoA dehydrogenase activity
B2B12_RS13205	COG2985	domain, Protein
B2B12_RS13220	COG0123	including yeast histone deacetylase and acetoin utilization protein
B2B12_RS13225	COG2951	lytic endotransglycosylase activity
B2B12_RS13235	COG0587	DNA-directed DNA polymerase activity
B2B12_RS13240	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B2B12_RS13245	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
B2B12_RS13250	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
B2B12_RS13270	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
B2B12_RS13275	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
B2B12_RS13285	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B2B12_RS13290	COG0077	Prephenate dehydratase
B2B12_RS13290	COG1605	Chorismate mutase
B2B12_RS13295	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
B2B12_RS13310	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
B2B12_RS13330	COG0165	Argininosuccinate lyase
B2B12_RS13380	COG0586	Pfam SNARE associated Golgi protein
B2B12_RS13405	COG2951	lytic endotransglycosylase activity
B2B12_RS13410	COG2833	Protein of unknown function (DUF455)
B2B12_RS13425	COG1132	(ABC) transporter
B2B12_RS13440	COG3038	cytochrome b561
B2B12_RS13445	COG3237	CsbD-like
B2B12_RS13465	COG2823	Periplasmic or secreted lipoprotein
B2B12_RS13480	COG0672	)-iron permease
B2B12_RS13495	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
B2B12_RS13500	COG1028	Short-chain dehydrogenase reductase Sdr
B2B12_RS13505	COG3243	poly(R)-hydroxyalkanoic acid synthase
B2B12_RS13515	COG0564	pseudouridine synthase activity
B2B12_RS13525	COG1199	ATP-dependent helicase activity
B2B12_RS13530	COG2183	response to ionizing radiation
B2B12_RS13555	COG4774	siderophore transport
B2B12_RS13565	COG1595	DNA-templated transcription, initiation
B2B12_RS13570	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
B2B12_RS13575	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B2B12_RS13580	COG0508	dehydrogenase complex catalyzes the overall conversion of
B2B12_RS13585	COG0567	Dehydrogenase, E1 component
B2B12_RS13590	COG1297	OPT oligopeptide transporter protein
B2B12_RS13600	COG0281	malic enzyme
B2B12_RS13600	COG0280	phosphate acetyltransferase
B2B12_RS13620	COG0488	(ABC) transporter
B2B12_RS13635	COG4608	Belongs to the ABC transporter superfamily
B2B12_RS13640	COG0444	Belongs to the ABC transporter superfamily
B2B12_RS13645	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B2B12_RS13660	COG1215	transferase activity, transferring glycosyl groups
B2B12_RS13665	COG0583	DNA-binding transcription factor activity
B2B12_RS13670	COG1368	sulfuric ester hydrolase activity
B2B12_RS13675	COG1686	Belongs to the peptidase S11 family
B2B12_RS13685	COG1280	lysine exporter protein (LysE YggA)
B2B12_RS13695	COG1064	alcohol dehydrogenase
B2B12_RS13700	COG4191	Histidine kinase
B2B12_RS13705	COG4566	intracellular signal transduction
B2B12_RS13715	COG1802	Transcriptional regulator
B2B12_RS13740	COG3181	Tripartite tricarboxylate transporter family receptor
B2B12_RS13745	COG0513	Belongs to the DEAD box helicase family
B2B12_RS13750	COG0668	transmembrane transport
B2B12_RS13765	COG1595	DNA-templated transcription, initiation
B2B12_RS13805	COG0583	DNA-binding transcription factor activity
B2B12_RS13810	COG0531	amino acid
B2B12_RS13815	COG1982	Orn Lys Arg decarboxylase major
B2B12_RS13840	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
B2B12_RS13845	COG0459	protein refolding
B2B12_RS13855	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
B2B12_RS13860	COG1252	NADH dehydrogenase
B2B12_RS13865	COG0284	orotidine-5'-phosphate decarboxylase activity
B2B12_RS13875	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
B2B12_RS13885	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B2B12_RS13890	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
B2B12_RS13920	COG1595	DNA-templated transcription, initiation
B2B12_RS13930	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
B2B12_RS13935	COG3639	organic phosphonate transmembrane transporter activity
B2B12_RS13940	COG3639	organic phosphonate transmembrane transporter activity
B2B12_RS13955	COG0742	ribosomal rna small subunit methyltransferase
B2B12_RS13960	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
B2B12_RS13965	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
B2B12_RS13970	COG3135	benzoate transporter
B2B12_RS13990	COG4774	siderophore transport
B2B12_RS14015	COG1024	Enoyl-CoA hydratase
B2B12_RS14020	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B2B12_RS14025	COG1960	acyl-CoA dehydrogenase activity
B2B12_RS14035	COG0318	PFAM AMP-dependent synthetase and ligase
B2B12_RS14040	COG3181	Tripartite tricarboxylate transporter family receptor
B2B12_RS14050	COG0583	DNA-binding transcription factor activity
B2B12_RS14075	COG0277	FAD linked oxidase domain protein
B2B12_RS14095	COG1802	Transcriptional regulator
B2B12_RS14105	COG2271	Major facilitator Superfamily
B2B12_RS14115	COG0583	DNA-binding transcription factor activity
B2B12_RS14140	COG0012	GTP binding
B2B12_RS14150	COG0193	aminoacyl-tRNA hydrolase activity
B2B12_RS14155	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
B2B12_RS14160	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
B2B12_RS14170	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
B2B12_RS14185	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
B2B12_RS14210	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
B2B12_RS14220	COG1368	sulfuric ester hydrolase activity
B2B12_RS14225	COG2186	Transcriptional regulator
B2B12_RS14235	COG3181	Tripartite tricarboxylate transporter family receptor
B2B12_RS14250	COG0277	FAD linked oxidase domain protein
B2B12_RS14265	COG0166	Belongs to the GPI family
B2B12_RS14270	COG0438	transferase activity, transferring glycosyl groups
B2B12_RS14275	COG0438	transferase activity, transferring glycosyl groups
B2B12_RS14290	COG0438	transferase activity, transferring glycosyl groups
B2B12_RS14305	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
B2B12_RS14310	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B2B12_RS14325	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
B2B12_RS14335	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
B2B12_RS14345	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B2B12_RS14350	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B2B12_RS14365	COG0747	negative chemotaxis
B2B12_RS14375	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B2B12_RS14380	COG4172	Belongs to the ABC transporter superfamily
B2B12_RS14405	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B2B12_RS14405	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B2B12_RS14410	COG0509	glycine decarboxylation via glycine cleavage system
B2B12_RS14415	COG0404	The glycine cleavage system catalyzes the degradation of glycine
B2B12_RS14420	COG2081	HI0933 family
B2B12_RS14435	COG0456	acetyltransferase
B2B12_RS14440	COG0717	Belongs to the dCTP deaminase family
B2B12_RS14455	COG0489	protein tyrosine kinase activity
B2B12_RS14465	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B2B12_RS14465	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B2B12_RS14505	COG0745	RESPONSE REGULATOR receiver
B2B12_RS14530	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
B2B12_RS14545	COG2084	Dehydrogenase
B2B12_RS14550	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B2B12_RS14575	COG3842	ATPase activity
B2B12_RS14580	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
B2B12_RS14585	COG1960	acyl-CoA dehydrogenase activity
B2B12_RS14595	COG0583	DNA-binding transcription factor activity
B2B12_RS14605	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B2B12_RS14610	COG1024	Enoyl-CoA hydratase
B2B12_RS14625	COG0583	DNA-binding transcription factor activity
B2B12_RS14630	COG1408	metallophosphoesterase
B2B12_RS14635	COG0625	glutathione transferase activity
B2B12_RS14670	COG0426	domain, Protein
B2B12_RS14670	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
B2B12_RS14675	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B2B12_RS14680	COG0583	DNA-binding transcription factor activity
B2B12_RS14690	COG1024	Enoyl-CoA hydratase
B2B12_RS14700	COG1960	acyl-CoA dehydrogenase activity
B2B12_RS14705	COG1028	Short-chain dehydrogenase reductase Sdr
B2B12_RS14710	COG1028	Short-chain dehydrogenase reductase Sdr
B2B12_RS14730	COG3181	Tripartite tricarboxylate transporter family receptor
B2B12_RS14735	COG1028	Short-chain dehydrogenase reductase Sdr
B2B12_RS14745	COG3181	Tripartite tricarboxylate transporter family receptor
B2B12_RS14785	COG0583	DNA-binding transcription factor activity
B2B12_RS14790	COG1960	acyl-CoA dehydrogenase activity
B2B12_RS14795	COG3181	Tripartite tricarboxylate transporter family receptor
B2B12_RS14800	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B2B12_RS14805	COG0220	tRNA (guanine-N7-)-methyltransferase activity
B2B12_RS14835	COG0560	Phosphoserine phosphatase
B2B12_RS14840	COG0583	DNA-binding transcription factor activity
B2B12_RS14855	COG3842	ATPase activity
B2B12_RS14870	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
B2B12_RS14890	COG0625	glutathione transferase activity
B2B12_RS14935	COG4336	lyase activity
B2B12_RS14945	COG0326	Molecular chaperone. Has ATPase activity
B2B12_RS14950	COG2233	PERMEase
B2B12_RS14990	COG2818	Glycosylase
B2B12_RS14995	COG0727	PFAM Uncharacterised protein family (UPF0153)
B2B12_RS15020	COG0402	S-adenosylhomocysteine deaminase activity
B2B12_RS15030	COG0156	8-amino-7-oxononanoate synthase activity
B2B12_RS15035	COG2877	3-deoxy-8-phosphooctulonate synthase activity
B2B12_RS15085	COG1464	Belongs to the NlpA lipoprotein family
B2B12_RS15090	COG2011	ABC-type metal ion transport system permease component
B2B12_RS15095	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
B2B12_RS15100	COG1501	Belongs to the glycosyl hydrolase 31 family
B2B12_RS15105	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B2B12_RS15105	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
B2B12_RS15110	COG0483	inositol monophosphate 1-phosphatase activity
B2B12_RS15115	COG0318	PFAM AMP-dependent synthetase and ligase
B2B12_RS15120	COG1473	amidohydrolase
B2B12_RS15125	COG0583	DNA-binding transcription factor activity
B2B12_RS15130	COG2855	membrane
B2B12_RS15140	COG2239	Acts as a magnesium transporter
B2B12_RS15155	COG1522	sequence-specific DNA binding
B2B12_RS15195	COG0330	HflC and HflK could
B2B12_RS15200	COG0330	HflC and HflK could
B2B12_RS15205	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
B2B12_RS15210	COG1923	regulation of RNA biosynthetic process
B2B12_RS15220	COG1160	GTP binding
B2B12_RS15225	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B2B12_RS15230	COG2976	Protein conserved in bacteria
B2B12_RS15235	COG0124	histidyl-tRNA synthetase
B2B12_RS15250	COG0820	rRNA (adenine-C2-)-methyltransferase activity
B2B12_RS15255	COG0105	UTP biosynthetic process
B2B12_RS15260	COG0525	valine-tRNA ligase activity
B2B12_RS15270	COG0336	Belongs to the RNA methyltransferase TrmD family
B2B12_RS15275	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
B2B12_RS15280	COG0228	four-way junction DNA binding
B2B12_RS15285	COG0425	Belongs to the sulfur carrier protein TusA family
B2B12_RS15290	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
B2B12_RS15355	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B2B12_RS15360	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
B2B12_RS15360	COG0543	2 iron, 2 sulfur cluster binding
B2B12_RS15365	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
B2B12_RS15370	COG2076	Multidrug Resistance protein
B2B12_RS15375	COG0633	Ferredoxin
B2B12_RS15375	COG3217	Mosc domain protein beta barrel domain protein
B2B12_RS15380	COG5285	phytanoyl-CoA dioxygenase
B2B12_RS15385	COG0662	Cupin 2, conserved barrel domain protein
B2B12_RS15395	COG0456	acetyltransferase
B2B12_RS15410	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B2B12_RS15440	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
B2B12_RS15450	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
B2B12_RS15455	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
B2B12_RS15460	COG1760	l-serine dehydratase
B2B12_RS15465	COG1283	sodium-dependent phosphate transmembrane transporter activity
B2B12_RS15470	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B2B12_RS15475	COG0412	Dienelactone hydrolase
B2B12_RS15480	COG0428	transporter
B2B12_RS15490	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
B2B12_RS15500	COG1845	cytochrome c oxidase, subunit III
B2B12_RS15505	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
B2B12_RS15515	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B2B12_RS15515	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B2B12_RS15540	COG1942	4-Oxalocrotonate Tautomerase
B2B12_RS15550	COG4176	ABC-type proline glycine betaine transport system permease component
B2B12_RS15570	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
B2B12_RS15575	COG2814	Major facilitator Superfamily
B2B12_RS15580	COG0227	Belongs to the bacterial ribosomal protein bL28 family
B2B12_RS15585	COG0267	Belongs to the bacterial ribosomal protein bL33 family
B2B12_RS15610	COG1846	Transcriptional regulator
B2B12_RS15615	COG2814	Major facilitator Superfamily
B2B12_RS15620	COG0495	leucyl-tRNA aminoacylation
B2B12_RS15635	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
B2B12_RS15655	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B2B12_RS15660	COG2274	protein secretion by the type I secretion system
B2B12_RS15705	COG0427	acetyl-CoA hydrolase
B2B12_RS15715	COG1511	domain protein
B2B12_RS15715	COG3264	Mechanosensitive ion channel
B2B12_RS15720	COG0730	response to heat
B2B12_RS15735	COG2176	DNA-directed DNA polymerase activity
B2B12_RS15755	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
B2B12_RS15760	COG3384	dioxygenase
B2B12_RS15775	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
B2B12_RS15845	COG4964	Belongs to the GSP D family
B2B12_RS15890	COG1846	Transcriptional regulator
B2B12_RS15925	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
B2B12_RS15935	COG2070	2-Nitropropane dioxygenase
B2B12_RS15940	COG2070	2-Nitropropane dioxygenase
B2B12_RS15950	COG2610	gluconate transmembrane transporter activity
B2B12_RS15965	COG1408	metallophosphoesterase
B2B12_RS15970	COG0493	'glutamate synthase
B2B12_RS15970	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
B2B12_RS15975	COG2199	diguanylate cyclase activity
B2B12_RS15980	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
B2B12_RS16015	COG2159	amidohydrolase
B2B12_RS16025	COG0583	DNA-binding transcription factor activity
B2B12_RS16040	COG1024	Enoyl-CoA hydratase
B2B12_RS16045	COG2186	Transcriptional regulator
B2B12_RS16050	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B2B12_RS16060	COG0833	amino acid
B2B12_RS16070	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
B2B12_RS16105	COG5265	(ABC) transporter
B2B12_RS16145	COG1971	Probably functions as a manganese efflux pump
B2B12_RS16150	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
B2B12_RS16160	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B2B12_RS16165	COG2814	Major facilitator Superfamily
B2B12_RS16190	COG4608	Belongs to the ABC transporter superfamily
B2B12_RS16210	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B2B12_RS16220	COG3383	formate dehydrogenase (NAD+) activity
B2B12_RS16235	COG0747	negative chemotaxis
B2B12_RS16245	COG0625	glutathione transferase activity
B2B12_RS16275	COG1595	DNA-templated transcription, initiation
B2B12_RS16285	COG4774	siderophore transport
B2B12_RS16300	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B2B12_RS16315	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
B2B12_RS16320	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
B2B12_RS16345	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B2B12_RS16350	COG1024	Enoyl-CoA hydratase
B2B12_RS16385	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B2B12_RS16390	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B2B12_RS16395	COG1116	anion transmembrane transporter activity
B2B12_RS16405	COG3585	molybdate ion transport
B2B12_RS16465	COG0583	DNA-binding transcription factor activity
B2B12_RS16470	COG4948	Mandelate Racemase Muconate Lactonizing
B2B12_RS16475	COG3181	Tripartite tricarboxylate transporter family receptor
B2B12_RS16505	COG3181	Tripartite tricarboxylate transporter family receptor
B2B12_RS16540	COG4177	L-phenylalanine transmembrane transporter activity
B2B12_RS16565	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
B2B12_RS16580	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
B2B12_RS16585	COG1538	Outer membrane efflux protein
B2B12_RS16590	COG1136	(ABC) transporter
B2B12_RS16590	COG0577	efflux transmembrane transporter activity
B2B12_RS16595	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B2B12_RS16610	COG0259	pyridoxamine-phosphate oxidase activity
B2B12_RS16615	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
B2B12_RS16620	COG0579	oxidoreductase
B2B12_RS16630	COG0405	Gamma-glutamyltransferase
B2B12_RS16640	COG3181	Tripartite tricarboxylate transporter family receptor
B2B12_RS16650	COG0114	fumarate hydratase activity
B2B12_RS16655	COG0802	atpase or kinase
B2B12_RS16660	COG0860	N-Acetylmuramoyl-L-alanine amidase
B2B12_RS16665	COG0586	Pfam SNARE associated Golgi protein
B2B12_RS16670	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
B2B12_RS16675	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
B2B12_RS16680	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
B2B12_RS16695	COG0617	tRNA 3'-terminal CCA addition
B2B12_RS16730	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
B2B12_RS16740	COG1024	Enoyl-CoA hydratase
B2B12_RS16750	COG2188	Transcriptional regulator
B2B12_RS16755	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
B2B12_RS16770	COG0752	glycyl-tRNA synthetase alpha subunit
B2B12_RS16775	COG0751	glycine-tRNA ligase activity
B2B12_RS16780	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
B2B12_RS16785	COG0204	Acyl-transferase
B2B12_RS16815	COG0242	peptide deformylase activity
B2B12_RS16825	COG0700	Nucleoside recognition
B2B12_RS16830	COG0469	pyruvate kinase activity
B2B12_RS16835	COG1929	Belongs to the glycerate kinase type-1 family
B2B12_RS16845	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
B2B12_RS16850	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B2B12_RS16855	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
B2B12_RS16865	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
B2B12_RS16875	COG2154	pterin-4-alpha-carbinolamine dehydratase
B2B12_RS16880	COG2885	chlorophyll binding
B2B12_RS16890	COG0667	Aldo Keto reductase
B2B12_RS16900	COG3181	Tripartite tricarboxylate transporter family receptor
B2B12_RS16920	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B2B12_RS16925	COG0288	reversible hydration of carbon dioxide
B2B12_RS16945	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
B2B12_RS16955	COG4829	muconolactone delta-isomerase
B2B12_RS16960	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
B2B12_RS16970	COG1414	Transcriptional regulator
B2B12_RS16975	COG1028	Short-chain dehydrogenase reductase Sdr
B2B12_RS16980	COG2031	fatty acid transporter
B2B12_RS16985	COG1250	3-hydroxyacyl-CoA dehydrogenase
B2B12_RS16995	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
B2B12_RS17000	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
B2B12_RS17015	COG0129	dihydroxy-acid dehydratase activity
B2B12_RS17020	COG1609	Transcriptional regulator
B2B12_RS17040	COG4106	trans-aconitate 2-methyltransferase activity
B2B12_RS17060	COG0820	rRNA (adenine-C2-)-methyltransferase activity
B2B12_RS17095	COG0163	prenyltransferase activity
B2B12_RS17100	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
B2B12_RS17105	COG2890	protein-(glutamine-N5) methyltransferase activity
B2B12_RS17110	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
B2B12_RS17115	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
B2B12_RS17130	COG3712	iron ion homeostasis
B2B12_RS17160	COG0659	secondary active sulfate transmembrane transporter activity
B2B12_RS17180	COG1028	Short-chain dehydrogenase reductase Sdr
B2B12_RS17195	COG4774	siderophore transport
B2B12_RS17205	COG1595	DNA-templated transcription, initiation
B2B12_RS17220	COG0142	geranyltranstransferase activity
B2B12_RS17225	COG0261	This protein binds to 23S rRNA in the presence of protein L20
B2B12_RS17230	COG0211	Belongs to the bacterial ribosomal protein bL27 family
B2B12_RS17235	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
B2B12_RS17240	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
B2B12_RS17260	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B2B12_RS17260	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B2B12_RS17265	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
B2B12_RS17280	COG0583	DNA-binding transcription factor activity
B2B12_RS17285	COG0861	Integral membrane protein TerC family
B2B12_RS17300	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
B2B12_RS17305	COG0793	Belongs to the peptidase S41A family
B2B12_RS17310	COG4942	peptidase
B2B12_RS17315	COG0588	phosphoglycerate mutase activity
B2B12_RS17325	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
B2B12_RS17330	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
B2B12_RS17335	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
B2B12_RS17340	COG3181	Tripartite tricarboxylate transporter family receptor
B2B12_RS17355	COG2226	methyltransferase
B2B12_RS17360	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
B2B12_RS17365	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B2B12_RS17375	COG2204	response regulator
B2B12_RS17380	COG5000	phosphorelay sensor kinase activity
B2B12_RS17390	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B2B12_RS17390	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
B2B12_RS17430	COG2188	Transcriptional regulator
B2B12_RS17445	COG0583	DNA-binding transcription factor activity
B2B12_RS17450	COG1012	belongs to the aldehyde dehydrogenase family
B2B12_RS17470	COG0546	phosphoglycolate phosphatase activity
B2B12_RS17485	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
B2B12_RS17490	COG0242	peptide deformylase activity
B2B12_RS17500	COG1522	sequence-specific DNA binding
B2B12_RS17505	COG2879	small protein
B2B12_RS17510	COG1966	Carbon starvation protein
B2B12_RS17540	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B2B12_RS17545	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B2B12_RS17550	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
B2B12_RS17555	COG3181	Tripartite tricarboxylate transporter family receptor
B2B12_RS17620	COG1172	Belongs to the binding-protein-dependent transport system permease family
B2B12_RS17655	COG0640	Transcriptional regulator
B2B12_RS17695	COG0735	belongs to the Fur family
B2B12_RS17700	COG2207	Transcriptional regulator
B2B12_RS17705	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
B2B12_RS17710	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
B2B12_RS17715	COG0513	Belongs to the DEAD box helicase family
B2B12_RS17745	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
B2B12_RS17760	COG1305	Transglutaminase-like
B2B12_RS17800	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
B2B12_RS17805	COG1950	PFAM Membrane protein of
B2B12_RS17830	COG0024	Methionine aminopeptidase
B2B12_RS17835	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
B2B12_RS17845	COG1560	Kdo2-lipid A biosynthetic process
B2B12_RS17850	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
B2B12_RS17860	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
B2B12_RS17895	COG0735	belongs to the Fur family
B2B12_RS17900	COG0523	cobalamin synthesis protein
B2B12_RS17915	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
B2B12_RS17925	COG2096	Adenosyltransferase
B2B12_RS17930	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
B2B12_RS17935	COG0321	lipoyl(octanoyl) transferase activity
B2B12_RS17945	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B2B12_RS17950	COG1686	Belongs to the peptidase S11 family
B2B12_RS17975	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
B2B12_RS17985	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
B2B12_RS17995	COG0859	PFAM glycosyl transferase family 9
B2B12_RS18030	COG0477	Major facilitator Superfamily
B2B12_RS18045	COG3568	Endonuclease Exonuclease Phosphatase
B2B12_RS18050	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
B2B12_RS18080	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B2B12_RS18085	COG1956	GAF domain-containing protein
B2B12_RS18090	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B2B12_RS18105	COG2186	Transcriptional regulator
B2B12_RS18110	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
B2B12_RS18125	COG1840	ABC-type Fe3 transport system, periplasmic component
B2B12_RS18165	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
B2B12_RS18170	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
B2B12_RS18175	COG1086	Polysaccharide biosynthesis protein
B2B12_RS18210	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
B2B12_RS18220	COG1028	Short-chain dehydrogenase reductase Sdr
B2B12_RS18225	COG1012	belongs to the aldehyde dehydrogenase family
B2B12_RS18250	COG1522	sequence-specific DNA binding
B2B12_RS18255	COG3781	membrane
B2B12_RS18295	COG2200	EAL domain
B2B12_RS18305	COG0592	DNA-directed DNA polymerase activity
B2B12_RS18310	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
B2B12_RS18315	COG0230	Belongs to the bacterial ribosomal protein bL34 family
B2B12_RS18320	COG0594	ribonuclease P activity
B2B12_RS18325	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
B2B12_RS18330	COG0706	membrane insertase activity
B2B12_RS18335	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
B2B12_RS18340	COG1473	amidohydrolase
B2B12_RS18345	COG4608	Belongs to the ABC transporter superfamily
B2B12_RS18350	COG0444	Belongs to the ABC transporter superfamily
B2B12_RS18355	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B2B12_RS18360	COG0601	transmembrane transport
B2B12_RS18370	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
B2B12_RS18375	COG1505	serine-type exopeptidase activity
B2B12_RS18385	COG0280	phosphate acetyltransferase
B2B12_RS18385	COG0281	malic enzyme
B2B12_RS18415	COG0436	Aminotransferase
B2B12_RS18420	COG1278	Cold shock