locus-tag	class	description
BTL46_RS00005	COG0445	tRNA wobble uridine modification
BTL46_RS00010	COG0357	Ribosomal RNA small subunit methyltransferase G
BTL46_RS00015	COG1192	Involved in chromosome partitioning
BTL46_RS00020	COG1475	DNA binding
BTL46_RS00025	COG0252	asparaginase activity
BTL46_RS00045	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BTL46_RS00055	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BTL46_RS00065	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BTL46_RS00070	COG0081	regulation of translation
BTL46_RS00075	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BTL46_RS00080	COG0222	ribosome binding
BTL46_RS00085	COG0085	RNA polymerase activity
BTL46_RS00090	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BTL46_RS00125	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BTL46_RS00130	COG0049	tRNA binding
BTL46_RS00135	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BTL46_RS00140	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BTL46_RS00145	COG0051	transcription antitermination factor activity, RNA binding
BTL46_RS00150	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BTL46_RS00155	COG0088	Forms part of the polypeptide exit tunnel
BTL46_RS00160	COG0089	rRNA binding
BTL46_RS00165	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BTL46_RS00170	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BTL46_RS00175	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BTL46_RS00180	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BTL46_RS00185	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BTL46_RS00190	COG0255	Belongs to the universal ribosomal protein uL29 family
BTL46_RS00195	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BTL46_RS00205	COG4177	L-phenylalanine transmembrane transporter activity
BTL46_RS00215	COG1129	ABC transporter
BTL46_RS00220	COG0411	ABC transporter
BTL46_RS00250	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BTL46_RS00255	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BTL46_RS00260	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BTL46_RS00265	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BTL46_RS00270	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BTL46_RS00275	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BTL46_RS00280	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BTL46_RS00285	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BTL46_RS00290	COG1841	ribosomal large subunit assembly
BTL46_RS00295	COG0200	Binds to the 23S rRNA
BTL46_RS00300	COG0201	protein transport
BTL46_RS00305	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BTL46_RS00310	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BTL46_RS00315	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BTL46_RS00320	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BTL46_RS00325	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BTL46_RS00330	COG0202	RNA polymerase activity
BTL46_RS00335	COG0203	ribosomal protein L17
BTL46_RS00340	COG0537	adenosine 5'-monophosphoramidase activity
BTL46_RS00345	COG1324	tolerance protein
BTL46_RS00350	COG4232	protein-disulfide reductase activity
BTL46_RS00365	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BTL46_RS00375	COG1333	cytochrome c biogenesis protein
BTL46_RS00380	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BTL46_RS00395	COG1965	Belongs to the frataxin family
BTL46_RS00405	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BTL46_RS00410	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BTL46_RS00415	COG0232	Belongs to the dGTPase family. Type 2 subfamily
BTL46_RS00435	COG2814	Major facilitator Superfamily
BTL46_RS00480	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BTL46_RS00485	COG2922	Belongs to the Smg family
BTL46_RS00490	COG1629	transport
BTL46_RS00500	COG2358	TRAP transporter, solute receptor (TAXI family
BTL46_RS00510	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BTL46_RS00525	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BTL46_RS00530	COG0183	Belongs to the thiolase family
BTL46_RS00535	COG1960	acyl-CoA dehydrogenase activity
BTL46_RS00560	COG2200	EAL domain
BTL46_RS00565	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BTL46_RS00575	COG0018	arginyl-trna synthetase
BTL46_RS00590	COG0154	amidase activity
BTL46_RS00595	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BTL46_RS00605	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
BTL46_RS00615	COG0697	spore germination
BTL46_RS00675	COG3350	monooxygenase activity
BTL46_RS00700	COG1309	transcriptional regulator
BTL46_RS00730	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
BTL46_RS00735	COG1280	lysine exporter protein (LysE YggA)
BTL46_RS00740	COG0513	Belongs to the DEAD box helicase family
BTL46_RS00750	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
BTL46_RS00755	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BTL46_RS00785	COG2969	positive regulation of protein catabolic process
BTL46_RS00790	COG0625	glutathione transferase activity
BTL46_RS00795	COG2857	Cytochrome c1
BTL46_RS00800	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BTL46_RS00805	COG0723	plastoquinol--plastocyanin reductase activity
BTL46_RS00810	COG1970	mechanosensitive ion channel activity
BTL46_RS00815	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BTL46_RS00820	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BTL46_RS00830	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BTL46_RS00835	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BTL46_RS00845	COG0140	phosphoribosyl-ATP diphosphatase activity
BTL46_RS00850	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BTL46_RS00855	COG0107	imidazoleglycerol-phosphate synthase activity
BTL46_RS00860	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BTL46_RS00870	COG0131	Imidazoleglycerol-phosphate dehydratase
BTL46_RS00875	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BTL46_RS00880	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
BTL46_RS00885	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BTL46_RS00890	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BTL46_RS00900	COG0842	Transport permease protein
BTL46_RS00905	COG1131	(ABC) transporter
BTL46_RS00920	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BTL46_RS00925	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BTL46_RS00930	COG1127	ABC transporter
BTL46_RS00950	COG0067	glutamate synthase
BTL46_RS00950	COG0070	glutamate synthase
BTL46_RS00950	COG0069	glutamate synthase activity
BTL46_RS00975	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
BTL46_RS01000	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BTL46_RS01005	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
BTL46_RS01045	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BTL46_RS01080	COG0109	protoheme IX farnesyltransferase activity
BTL46_RS01085	COG1999	signal sequence binding
BTL46_RS01105	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BTL46_RS01110	COG2814	Major facilitator Superfamily
BTL46_RS01125	COG1522	sequence-specific DNA binding
BTL46_RS01185	COG4948	Mandelate Racemase Muconate Lactonizing
BTL46_RS01200	COG3119	arylsulfatase activity
BTL46_RS01240	COG0402	S-adenosylhomocysteine deaminase activity
BTL46_RS01250	COG1304	FMN binding
BTL46_RS01255	COG1254	Belongs to the acylphosphatase family
BTL46_RS01265	COG3181	Tripartite tricarboxylate transporter family receptor
BTL46_RS01275	COG1414	Transcriptional regulator
BTL46_RS01295	COG0028	Belongs to the TPP enzyme family
BTL46_RS01300	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
BTL46_RS01305	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BTL46_RS01310	COG1960	acyl-CoA dehydrogenase activity
BTL46_RS01345	COG3181	Tripartite tricarboxylate transporter family receptor
BTL46_RS01350	COG0583	DNA-binding transcription factor activity
BTL46_RS01365	COG0129	dihydroxy-acid dehydratase activity
BTL46_RS01370	COG2084	Dehydrogenase
BTL46_RS01385	COG1671	Belongs to the UPF0178 family
BTL46_RS01390	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
BTL46_RS01405	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
BTL46_RS01410	COG0443	Heat shock 70 kDa protein
BTL46_RS01435	COG2169	Transcriptional regulator
BTL46_RS01435	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BTL46_RS01450	COG1683	Conserved Protein
BTL46_RS01455	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BTL46_RS01470	COG1120	ATPase activity
BTL46_RS01475	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BTL46_RS01480	COG4558	Periplasmic binding protein
BTL46_RS01485	COG3720	iron ion transport
BTL46_RS01495	COG3712	iron ion homeostasis
BTL46_RS01500	COG1595	DNA-templated transcription, initiation
BTL46_RS01520	COG1607	acyl-coa hydrolase
BTL46_RS01530	COG0243	molybdopterin cofactor binding
BTL46_RS01530	COG3383	formate dehydrogenase (NAD+) activity
BTL46_RS01535	COG0243	molybdopterin cofactor binding
BTL46_RS01535	COG3383	formate dehydrogenase (NAD+) activity
BTL46_RS01540	COG0437	4 iron, 4 sulfur cluster binding
BTL46_RS01545	COG2864	formate dehydrogenase
BTL46_RS01560	COG3276	selenocysteine insertion sequence binding
BTL46_RS01595	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BTL46_RS01600	COG0512	Glutamine amidotransferase of anthranilate synthase
BTL46_RS01610	COG0546	phosphoglycolate phosphatase activity
BTL46_RS01615	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BTL46_RS01620	COG2967	ApaG domain
BTL46_RS01625	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
BTL46_RS01630	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BTL46_RS01635	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BTL46_RS01640	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BTL46_RS01645	COG0037	tRNA processing
BTL46_RS01665	COG1024	Enoyl-CoA hydratase
BTL46_RS01680	COG0356	it plays a direct role in the translocation of protons across the membrane
BTL46_RS01690	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BTL46_RS01695	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BTL46_RS01700	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BTL46_RS01705	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BTL46_RS01710	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BTL46_RS01715	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BTL46_RS01735	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
BTL46_RS01740	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BTL46_RS01745	COG0210	DNA helicase
BTL46_RS01760	COG4608	Belongs to the ABC transporter superfamily
BTL46_RS01765	COG0444	Belongs to the ABC transporter superfamily
BTL46_RS01770	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BTL46_RS01795	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BTL46_RS01800	COG1024	Enoyl-CoA hydratase
BTL46_RS01805	COG1024	Enoyl-CoA hydratase
BTL46_RS01810	COG2070	2-Nitropropane dioxygenase
BTL46_RS01825	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BTL46_RS01830	COG1250	3-hydroxyacyl-CoA dehydrogenase
BTL46_RS01850	COG2267	carboxylic ester hydrolase activity
BTL46_RS01870	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
BTL46_RS01880	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BTL46_RS01880	COG2813	Specifically methylates the guanine in position
BTL46_RS01885	COG2223	nitrite transmembrane transporter activity
BTL46_RS01890	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
BTL46_RS01905	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BTL46_RS01910	COG0708	Exodeoxyribonuclease III
BTL46_RS01915	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BTL46_RS01920	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BTL46_RS01925	COG0154	amidase activity
BTL46_RS01930	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BTL46_RS01935	COG1077	Cell shape determining protein MreB Mrl
BTL46_RS01940	COG1792	Involved in formation and maintenance of cell shape
BTL46_RS01950	COG0768	penicillin binding
BTL46_RS01955	COG0772	Belongs to the SEDS family
BTL46_RS01960	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
BTL46_RS01965	COG0471	metal ion transport
BTL46_RS01970	COG1309	transcriptional regulator
BTL46_RS01980	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BTL46_RS01995	COG2823	Periplasmic or secreted lipoprotein
BTL46_RS02000	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
BTL46_RS02005	COG0792	nuclease activity
BTL46_RS02025	COG1660	Displays ATPase and GTPase activities
BTL46_RS02040	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
BTL46_RS02050	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
BTL46_RS02060	COG3181	Tripartite tricarboxylate transporter family receptor
BTL46_RS02065	COG1473	amidohydrolase
BTL46_RS02070	COG1137	ATPase activity
BTL46_RS02085	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
BTL46_RS02095	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
BTL46_RS02115	COG1294	oxidase, subunit
BTL46_RS02125	COG4988	ABC transporter
BTL46_RS02130	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BTL46_RS02135	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BTL46_RS02150	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BTL46_RS02155	COG1238	metal cluster binding
BTL46_RS02165	COG1802	Transcriptional regulator
BTL46_RS02175	COG1984	allophanate hydrolase subunit 2
BTL46_RS02180	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
BTL46_RS02190	COG0583	DNA-binding transcription factor activity
BTL46_RS02195	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BTL46_RS02200	COG5002	protein histidine kinase activity
BTL46_RS02205	COG0745	RESPONSE REGULATOR receiver
BTL46_RS02210	COG2226	methyltransferase
BTL46_RS02255	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BTL46_RS02265	COG1028	Short-chain dehydrogenase reductase Sdr
BTL46_RS02285	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BTL46_RS02290	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BTL46_RS02300	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BTL46_RS02320	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
BTL46_RS02325	COG1538	Outer membrane efflux protein
BTL46_RS02335	COG0351	phosphomethylpyrimidine kinase
BTL46_RS02340	COG2022	thiamine diphosphate biosynthetic process
BTL46_RS02345	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BTL46_RS02365	COG2226	methyltransferase
BTL46_RS02375	COG1194	a g-specific adenine glycosylase
BTL46_RS02385	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
BTL46_RS02390	COG2177	Part of the ABC transporter FtsEX involved in
BTL46_RS02395	COG2884	Cell division ATP-binding protein ftsE
BTL46_RS02400	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BTL46_RS02405	COG4597	amino acid ABC transporter
BTL46_RS02410	COG0765	amino acid transport
BTL46_RS02415	COG1126	abc transporter atp-binding protein
BTL46_RS02435	COG0477	Major facilitator Superfamily
BTL46_RS02445	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
BTL46_RS02450	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
BTL46_RS02465	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
BTL46_RS02470	COG0237	dephospho-CoA kinase activity
BTL46_RS02475	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
BTL46_RS02485	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BTL46_RS02500	COG3539	Fimbrial protein
BTL46_RS02505	COG3539	Fimbrial protein
BTL46_RS02520	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
BTL46_RS02530	COG1846	Transcriptional regulator
BTL46_RS02595	COG1028	Short-chain dehydrogenase reductase Sdr
BTL46_RS02600	COG1024	Enoyl-CoA hydratase
BTL46_RS02605	COG1960	acyl-CoA dehydrogenase activity
BTL46_RS02635	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BTL46_RS02640	COG0352	thiamine-phosphate diphosphorylase activity
BTL46_RS02645	COG0351	phosphomethylpyrimidine kinase
BTL46_RS02655	COG1678	Uncharacterized ACR, COG1678
BTL46_RS02660	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BTL46_RS02685	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BTL46_RS02695	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BTL46_RS02700	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BTL46_RS02710	COG0557	exoribonuclease II activity
BTL46_RS02720	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BTL46_RS02725	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BTL46_RS02730	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BTL46_RS02740	COG0439	Biotin carboxylase
BTL46_RS02745	COG2264	protein methyltransferase activity
BTL46_RS02755	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BTL46_RS02780	COG1696	Membrane protein involved in D-alanine export
BTL46_RS02785	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BTL46_RS02815	COG1522	sequence-specific DNA binding
BTL46_RS02830	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BTL46_RS02895	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BTL46_RS02920	COG3028	Belongs to the UPF0307 family
BTL46_RS02925	COG0312	modulator of DNA gyrase
BTL46_RS02930	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BTL46_RS02935	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BTL46_RS02940	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
BTL46_RS02950	COG0316	Belongs to the HesB IscA family
BTL46_RS02960	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
BTL46_RS02970	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BTL46_RS02975	COG1881	PFAM PEBP family protein
BTL46_RS02980	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BTL46_RS02985	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BTL46_RS03000	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BTL46_RS03000	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BTL46_RS03015	COG2718	Belongs to the UPF0229 family
BTL46_RS03020	COG2719	SpoVR family
BTL46_RS03085	COG0165	Argininosuccinate lyase
BTL46_RS03090	COG0589	response to stress
BTL46_RS03100	COG2816	NAD+ diphosphatase activity
BTL46_RS03105	COG4993	Dehydrogenase
BTL46_RS03130	COG3181	Tripartite tricarboxylate transporter family receptor
BTL46_RS03135	COG2979	Protein of unknown function (DUF533)
BTL46_RS03140	COG4206	TonB-dependent receptor
BTL46_RS03155	COG0741	lytic transglycosylase activity
BTL46_RS03155	COG1388	LysM domain
BTL46_RS03160	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BTL46_RS03165	COG2226	methyltransferase
BTL46_RS03170	COG0328	RNA-DNA hybrid ribonuclease activity
BTL46_RS03195	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BTL46_RS03215	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BTL46_RS03220	COG1129	ABC transporter
BTL46_RS03220	COG0842	Transport permease protein
BTL46_RS03225	COG0842	Transport permease protein
BTL46_RS03245	COG0463	Glycosyl transferase, family 2
BTL46_RS03250	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
BTL46_RS03265	COG1073	alpha beta
BTL46_RS03275	COG0697	spore germination
BTL46_RS03280	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BTL46_RS03305	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BTL46_RS03335	COG0823	Involved in the tonB-independent uptake of proteins
BTL46_RS03345	COG0848	biopolymer transport protein
BTL46_RS03350	COG0811	peptide transport
BTL46_RS03355	COG0824	Thioesterase
BTL46_RS03360	COG0442	prolyl-tRNA aminoacylation
BTL46_RS03405	COG2084	Dehydrogenase
BTL46_RS03450	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BTL46_RS03455	COG4654	Cytochrome c, class I
BTL46_RS03460	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BTL46_RS03525	COG1473	amidohydrolase
BTL46_RS03530	COG0418	dihydroorotase activity
BTL46_RS03535	COG0488	(ABC) transporter
BTL46_RS03545	COG2001	Belongs to the MraZ family
BTL46_RS03550	COG0275	rRNA processing
BTL46_RS03555	COG3116	cell division
BTL46_RS03565	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BTL46_RS03570	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BTL46_RS03575	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BTL46_RS03585	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BTL46_RS03590	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BTL46_RS03595	COG1181	Belongs to the D-alanine--D-alanine ligase family
BTL46_RS03600	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BTL46_RS03615	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
BTL46_RS03630	COG0739	heme binding
BTL46_RS03635	COG0653	protein targeting
BTL46_RS03660	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
BTL46_RS03665	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BTL46_RS03675	COG0828	Belongs to the bacterial ribosomal protein bS21 family
BTL46_RS03715	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
BTL46_RS03730	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
BTL46_RS03755	COG0583	DNA-binding transcription factor activity
BTL46_RS03765	COG3181	Tripartite tricarboxylate transporter family receptor
BTL46_RS03770	COG2084	Dehydrogenase
BTL46_RS03780	COG1597	lipid kinase activity
BTL46_RS03780	COG1803	Methylglyoxal synthase
BTL46_RS03790	COG0671	phosphoesterase, PA-phosphatase related
BTL46_RS03810	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
BTL46_RS03815	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BTL46_RS03820	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BTL46_RS03825	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BTL46_RS03830	COG0649	NAD binding
BTL46_RS03835	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
BTL46_RS03845	COG1034	ATP synthesis coupled electron transport
BTL46_RS03850	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
BTL46_RS03855	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BTL46_RS03865	COG0713	ATP synthesis coupled electron transport
BTL46_RS03880	COG1007	ATP synthesis coupled electron transport
BTL46_RS03890	COG0560	Phosphoserine phosphatase
BTL46_RS03895	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BTL46_RS03900	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
BTL46_RS03905	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BTL46_RS03920	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BTL46_RS03925	COG0450	alkyl hydroperoxide reductase
BTL46_RS03945	COG1214	PFAM Peptidase M22, glycoprotease
BTL46_RS03950	COG1573	uracil-dna glycosylase
BTL46_RS03955	COG0477	Major facilitator Superfamily
BTL46_RS03960	COG1196	nuclear chromosome segregation
BTL46_RS03970	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BTL46_RS03975	COG1126	abc transporter atp-binding protein
BTL46_RS03980	COG0765	amino acid transport
BTL46_RS03985	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BTL46_RS03990	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BTL46_RS03995	COG2917	probably involved in intracellular septation
BTL46_RS04000	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BTL46_RS04005	COG1122	ATPase activity
BTL46_RS04010	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
BTL46_RS04045	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BTL46_RS04070	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BTL46_RS04075	COG2878	Part of a membrane complex involved in electron transport
BTL46_RS04095	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
BTL46_RS04100	COG0251	oxidation-reduction process
BTL46_RS04110	COG3228	Belongs to the MtfA family
BTL46_RS04115	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BTL46_RS04125	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BTL46_RS04135	COG0159	tryptophan synthase activity
BTL46_RS04140	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
BTL46_RS04145	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
BTL46_RS04160	COG1530	ribonuclease E activity
BTL46_RS04165	COG0564	pseudouridine synthase activity
BTL46_RS04170	COG0546	phosphoglycolate phosphatase activity
BTL46_RS04175	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BTL46_RS04180	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
BTL46_RS04185	COG3023	N-Acetylmuramoyl-L-alanine amidase
BTL46_RS04195	COG0424	maF-like protein
BTL46_RS04205	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BTL46_RS04215	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BTL46_RS04225	COG1028	Short-chain dehydrogenase reductase Sdr
BTL46_RS04230	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BTL46_RS04235	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BTL46_RS04260	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BTL46_RS04280	COG0481	GTPase activity
BTL46_RS04285	COG0681	Belongs to the peptidase S26 family
BTL46_RS04290	COG0571	ribonuclease III activity
BTL46_RS04295	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BTL46_RS04300	COG1381	Involved in DNA repair and RecF pathway recombination
BTL46_RS04330	COG0670	Belongs to the BI1 family
BTL46_RS04345	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BTL46_RS04370	COG0583	DNA-binding transcription factor activity
BTL46_RS04390	COG0791	NLP P60 protein
BTL46_RS04395	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BTL46_RS04400	COG3193	protein, possibly involved in utilization of glycolate and propanediol
BTL46_RS04410	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BTL46_RS04430	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
BTL46_RS04465	COG1446	asparaginase
BTL46_RS04470	COG4172	Belongs to the ABC transporter superfamily
BTL46_RS04475	COG0747	negative chemotaxis
BTL46_RS04480	COG0601	transmembrane transport
BTL46_RS04505	COG0504	CTP synthase activity
BTL46_RS04515	COG0148	phosphopyruvate hydratase activity
BTL46_RS04530	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BTL46_RS04540	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BTL46_RS04545	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BTL46_RS04590	COG1981	membrane
BTL46_RS04610	COG0039	L-malate dehydrogenase activity
BTL46_RS04615	COG2188	Transcriptional regulator
BTL46_RS04620	COG2009	succinate dehydrogenase
BTL46_RS04625	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
BTL46_RS04630	COG1053	succinate dehydrogenase
BTL46_RS04635	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BTL46_RS04640	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
BTL46_RS04645	COG0372	Belongs to the citrate synthase family
BTL46_RS04660	COG0583	DNA-binding transcription factor activity
BTL46_RS04665	COG3842	ATPase activity
BTL46_RS04685	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BTL46_RS04695	COG3128	pkhd-type hydroxylase
BTL46_RS04700	COG4774	siderophore transport
BTL46_RS04710	COG0280	phosphate acetyltransferase
BTL46_RS04710	COG0281	malic enzyme
BTL46_RS04720	COG1297	OPT oligopeptide transporter protein
BTL46_RS04725	COG0567	Dehydrogenase, E1 component
BTL46_RS04730	COG0508	dehydrogenase complex catalyzes the overall conversion of
BTL46_RS04735	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BTL46_RS04740	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
BTL46_RS04745	COG1595	DNA-templated transcription, initiation
BTL46_RS04755	COG4774	siderophore transport
BTL46_RS04780	COG2183	response to ionizing radiation
BTL46_RS04785	COG1199	ATP-dependent helicase activity
BTL46_RS04795	COG0564	pseudouridine synthase activity
BTL46_RS04805	COG3243	poly(R)-hydroxyalkanoic acid synthase
BTL46_RS04810	COG1028	Short-chain dehydrogenase reductase Sdr
BTL46_RS04815	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
BTL46_RS04830	COG0672	)-iron permease
BTL46_RS04845	COG2823	Periplasmic or secreted lipoprotein
BTL46_RS04865	COG3237	CsbD-like
BTL46_RS04870	COG3038	cytochrome b561
BTL46_RS04885	COG1132	(ABC) transporter
BTL46_RS04915	COG2833	Protein of unknown function (DUF455)
BTL46_RS04920	COG2951	lytic endotransglycosylase activity
BTL46_RS04945	COG0586	Pfam SNARE associated Golgi protein
BTL46_RS04985	COG0165	Argininosuccinate lyase
BTL46_RS05005	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BTL46_RS05020	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BTL46_RS05025	COG0077	Prephenate dehydratase
BTL46_RS05025	COG1605	Chorismate mutase
BTL46_RS05030	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BTL46_RS05040	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BTL46_RS05045	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BTL46_RS05065	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
BTL46_RS05070	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
BTL46_RS05075	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BTL46_RS05080	COG0587	DNA-directed DNA polymerase activity
BTL46_RS05090	COG2951	lytic endotransglycosylase activity
BTL46_RS05095	COG0123	including yeast histone deacetylase and acetoin utilization protein
BTL46_RS05110	COG2985	domain, Protein
BTL46_RS05115	COG1960	acyl-CoA dehydrogenase activity
BTL46_RS05120	COG0450	alkyl hydroperoxide reductase
BTL46_RS05125	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
BTL46_RS05130	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
BTL46_RS05135	COG4208	sulfate ABC transporter
BTL46_RS05140	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
BTL46_RS05145	COG0175	sulfate reduction
BTL46_RS05170	COG0335	large ribosomal subunit rRNA binding
BTL46_RS05190	COG3622	Belongs to the hyi family
BTL46_RS05195	COG1162	GTPase activity
BTL46_RS05200	COG0501	Belongs to the peptidase M48B family
BTL46_RS05205	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
BTL46_RS05210	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
BTL46_RS05215	COG3327	negative regulation of DNA-templated transcription, initiation
BTL46_RS05220	COG3396	Phenylacetate-CoA oxygenase
BTL46_RS05225	COG3460	Phenylacetate-CoA oxygenase
BTL46_RS05230	COG3396	Phenylacetate-CoA oxygenase
BTL46_RS05235	COG2151	metal-sulfur cluster biosynthetic enzyme
BTL46_RS05240	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BTL46_RS05245	COG1012	belongs to the aldehyde dehydrogenase family
BTL46_RS05250	COG1024	Enoyl-CoA hydratase
BTL46_RS05255	COG2050	protein possibly involved in aromatic compounds catabolism
BTL46_RS05290	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BTL46_RS05290	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BTL46_RS05300	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BTL46_RS05305	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
BTL46_RS05310	COG2346	COG2346, Truncated hemoglobins
BTL46_RS05315	COG3642	lipopolysaccharide core region biosynthetic process
BTL46_RS05325	COG3842	ATPase activity
BTL46_RS05330	COG1176	ABC-type spermidine putrescine transport system, permease component I
BTL46_RS05335	COG1177	transmembrane transport
BTL46_RS05355	COG1322	Protein conserved in bacteria
BTL46_RS05365	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
BTL46_RS05370	COG0704	Plays a role in the regulation of phosphate uptake
BTL46_RS05375	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
BTL46_RS05380	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
BTL46_RS05380	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BTL46_RS05385	COG1643	Atp-dependent helicase
BTL46_RS05400	COG0438	transferase activity, transferring glycosyl groups
BTL46_RS05405	COG0726	polysaccharide deacetylase
BTL46_RS05410	COG0463	Glycosyl transferase, family 2
BTL46_RS05445	COG1132	(ABC) transporter
BTL46_RS05465	COG0501	Belongs to the peptidase M48B family
BTL46_RS05515	COG1722	exodeoxyribonuclease VII activity
BTL46_RS05520	COG0142	geranyltranstransferase activity
BTL46_RS05525	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BTL46_RS05530	COG1469	GTP cyclohydrolase I activity
BTL46_RS05535	COG0360	Binds together with S18 to 16S ribosomal RNA
BTL46_RS05540	COG2965	DNA replication, synthesis of RNA primer
BTL46_RS05545	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BTL46_RS05550	COG0359	binds to the 23S rRNA
BTL46_RS05560	COG0305	Participates in initiation and elongation during chromosome replication
BTL46_RS05570	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
BTL46_RS05575	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
BTL46_RS05580	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BTL46_RS05585	COG3737	Protein of unknown function (DUF498/DUF598)
BTL46_RS05590	COG0436	Aminotransferase
BTL46_RS05615	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
BTL46_RS05620	COG0308	aminopeptidase N
BTL46_RS05635	COG0312	modulator of DNA gyrase
BTL46_RS05640	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BTL46_RS05665	COG0277	FAD linked oxidase domain protein
BTL46_RS05670	COG0277	FAD linked oxidase domain protein
BTL46_RS05675	COG0247	lactate metabolic process
BTL46_RS05715	COG0583	DNA-binding transcription factor activity
BTL46_RS05720	COG0482	sulfurtransferase activity
BTL46_RS05725	COG0730	response to heat
BTL46_RS05730	COG0625	glutathione transferase activity
BTL46_RS05735	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BTL46_RS05740	COG3909	cytochrome
BTL46_RS05775	COG3706	GGDEF domain
BTL46_RS05790	COG2826	transposase and inactivated derivatives, IS30 family
BTL46_RS05810	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
BTL46_RS05835	COG0069	glutamate synthase activity
BTL46_RS05840	COG2391	methyltransferase activity
BTL46_RS05845	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
BTL46_RS05850	COG0679	Auxin Efflux Carrier
BTL46_RS05855	COG2153	protein acetylation
BTL46_RS05875	COG0557	exoribonuclease II activity
BTL46_RS05880	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BTL46_RS05885	COG2873	o-acetylhomoserine
BTL46_RS05890	COG0776	regulation of translation
BTL46_RS05920	COG0642	Histidine kinase
BTL46_RS05925	COG3158	transport of potassium into the cell
BTL46_RS05950	COG0137	argininosuccinate synthase activity
BTL46_RS05955	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BTL46_RS05960	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BTL46_RS05970	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BTL46_RS05985	COG2186	Transcriptional regulator
BTL46_RS06020	COG3836	Belongs to the HpcH HpaI aldolase family
BTL46_RS06025	COG0268	Binds directly to 16S ribosomal RNA
BTL46_RS06075	COG0728	peptidoglycan biosynthetic process
BTL46_RS06085	COG0563	adenylate kinase activity
BTL46_RS06090	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
BTL46_RS06095	COG2835	tetraacyldisaccharide 4'-kinase activity
BTL46_RS06100	COG1663	tetraacyldisaccharide 4'-kinase activity
BTL46_RS06105	COG0848	biopolymer transport protein
BTL46_RS06110	COG0811	peptide transport
BTL46_RS06115	COG1570	exodeoxyribonuclease VII activity
BTL46_RS06120	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BTL46_RS06130	COG0038	chloride channel
BTL46_RS06135	COG0183	Belongs to the thiolase family
BTL46_RS06145	COG1278	Cold shock
BTL46_RS06150	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
BTL46_RS06160	COG4953	penicillin-binding protein 1C
BTL46_RS06175	COG3008	intermembrane lipid transfer
BTL46_RS06185	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
BTL46_RS06185	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
BTL46_RS06185	COG0506	proline dehydrogenase activity
BTL46_RS06220	COG0004	ammonium transporteR
BTL46_RS06225	COG0347	Belongs to the P(II) protein family
BTL46_RS06265	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BTL46_RS06270	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BTL46_RS06275	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BTL46_RS06280	COG0072	phenylalanine-tRNA ligase activity
BTL46_RS06280	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BTL46_RS06285	COG0776	regulation of translation
BTL46_RS06315	COG1802	Transcriptional regulator
BTL46_RS06320	COG3181	Tripartite tricarboxylate transporter family receptor
BTL46_RS06340	COG1278	Cold shock
BTL46_RS06350	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BTL46_RS06370	COG1522	sequence-specific DNA binding
BTL46_RS06390	COG0656	L-ascorbic acid biosynthetic process
BTL46_RS06395	COG0667	Aldo Keto reductase
BTL46_RS06410	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BTL46_RS06455	COG1610	YqeY-like protein
BTL46_RS06470	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BTL46_RS06475	COG3246	L-lysine catabolic process to acetate
BTL46_RS06495	COG0318	PFAM AMP-dependent synthetase and ligase
BTL46_RS06510	COG0183	Belongs to the thiolase family
BTL46_RS06515	COG1024	Enoyl-CoA hydratase
BTL46_RS06515	COG1250	3-hydroxyacyl-CoA dehydrogenase
BTL46_RS06525	COG1250	3-hydroxyacyl-CoA dehydrogenase
BTL46_RS06525	COG1024	Enoyl-CoA hydratase
BTL46_RS06530	COG0183	Belongs to the thiolase family
BTL46_RS06535	COG1960	acyl-CoA dehydrogenase activity
BTL46_RS06545	COG1045	serine acetyltransferase
BTL46_RS06555	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BTL46_RS06560	COG0483	inositol monophosphate 1-phosphatase activity
BTL46_RS06565	COG1012	belongs to the aldehyde dehydrogenase family
BTL46_RS06570	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
BTL46_RS06585	COG0210	DNA helicase
BTL46_RS06590	COG0598	Magnesium transport protein CorA
BTL46_RS06600	COG0747	negative chemotaxis
BTL46_RS06605	COG0601	transmembrane transport
BTL46_RS06610	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BTL46_RS06615	COG4172	Belongs to the ABC transporter superfamily
BTL46_RS06635	COG1346	cytolysis
BTL46_RS06645	COG1028	Short-chain dehydrogenase reductase Sdr
BTL46_RS06650	COG0783	Belongs to the Dps family
BTL46_RS06670	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
BTL46_RS06680	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BTL46_RS06685	COG1845	cytochrome c oxidase, subunit III
BTL46_RS06690	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
BTL46_RS06735	COG1666	GTP binding
BTL46_RS06760	COG1028	Short-chain dehydrogenase reductase Sdr
BTL46_RS06765	COG5006	permease, DMT superfamily
BTL46_RS06790	COG2264	protein methyltransferase activity
BTL46_RS06825	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BTL46_RS06830	COG0746	molybdenum cofactor guanylyltransferase activity
BTL46_RS06835	COG0303	'Molybdopterin
BTL46_RS06840	COG0521	Mo-molybdopterin cofactor biosynthetic process
BTL46_RS06845	COG0314	molybdopterin synthase activity
BTL46_RS06855	COG0315	cyclic pyranopterin monophosphate synthase activity
BTL46_RS06860	COG0412	Dienelactone hydrolase
BTL46_RS06870	COG0678	peroxiredoxin activity
BTL46_RS06885	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BTL46_RS06895	COG0542	response to heat
BTL46_RS06905	COG1477	protein flavinylation
BTL46_RS06930	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BTL46_RS06935	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
BTL46_RS06935	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
BTL46_RS06940	COG1562	ergosterol biosynthetic process
BTL46_RS06945	COG1562	ergosterol biosynthetic process
BTL46_RS06950	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BTL46_RS06990	COG0254	rRNA binding
BTL46_RS06995	COG3483	tryptophan 2,3-dioxygenase activity
BTL46_RS07000	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
BTL46_RS07005	COG2003	Belongs to the UPF0758 family
BTL46_RS07015	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BTL46_RS07020	COG0625	glutathione transferase activity
BTL46_RS07040	COG0523	cobalamin synthesis protein
BTL46_RS07050	COG0583	DNA-binding transcription factor activity
BTL46_RS07060	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BTL46_RS07065	COG1187	pseudouridine synthase activity
BTL46_RS07070	COG0779	Required for maturation of 30S ribosomal subunits
BTL46_RS07075	COG2251	uridine kinase activity
BTL46_RS07075	COG0195	Participates in both transcription termination and antitermination
BTL46_RS07080	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BTL46_RS07085	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BTL46_RS07090	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BTL46_RS07095	COG1217	gtp-binding protein TYPA
BTL46_RS07110	COG1802	Transcriptional regulator
BTL46_RS07120	COG1024	Enoyl-CoA hydratase
BTL46_RS07125	COG0318	PFAM AMP-dependent synthetase and ligase
BTL46_RS07135	COG2032	superoxide dismutase activity
BTL46_RS07150	COG4120	Belongs to the binding-protein-dependent transport system permease family
BTL46_RS07155	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
BTL46_RS07160	COG0725	ABC transporter, periplasmic molybdate-binding protein
BTL46_RS07165	COG4149	molybdate abc transporter
BTL46_RS07195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BTL46_RS07200	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BTL46_RS07205	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BTL46_RS07215	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
BTL46_RS07220	COG0736	holo-[acyl-carrier-protein] synthase activity
BTL46_RS07225	COG1472	Belongs to the glycosyl hydrolase 3 family
BTL46_RS07230	COG0322	excinuclease ABC activity
BTL46_RS07235	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BTL46_RS07245	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BTL46_RS07245	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BTL46_RS07250	COG2224	Isocitrate lyase
BTL46_RS07255	COG1846	Transcriptional regulator
BTL46_RS07260	COG1764	response to oxidative stress
BTL46_RS07265	COG1131	(ABC) transporter
BTL46_RS07275	COG0628	permease
BTL46_RS07290	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
BTL46_RS07300	COG2814	Major facilitator Superfamily
BTL46_RS07320	COG3015	lipoprotein NlpE involved in copper resistance
BTL46_RS07330	COG3530	Putative quorum-sensing-regulated virulence factor
BTL46_RS07345	COG0494	nUDIX hydrolase
BTL46_RS07355	COG0697	spore germination
BTL46_RS07360	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BTL46_RS07385	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BTL46_RS07390	COG1702	phosphate starvation-inducible protein PhoH
BTL46_RS07395	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BTL46_RS07400	COG4535	Mg2 and Co2 transporter CorC
BTL46_RS07405	COG0815	Transfers the fatty acyl group on membrane lipoproteins
BTL46_RS07410	COG0667	Aldo Keto reductase
BTL46_RS07430	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BTL46_RS07435	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BTL46_RS07440	COG1862	Preprotein translocase
BTL46_RS07445	COG0343	queuine tRNA-ribosyltransferase activity
BTL46_RS07450	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BTL46_RS07455	COG2027	D-alanyl-D-alanine carboxypeptidase
BTL46_RS07460	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BTL46_RS07465	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BTL46_RS07465	COG1648	precorrin-2 dehydrogenase activity
BTL46_RS07475	COG4575	ribosome binding
BTL46_RS07500	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
BTL46_RS07505	COG0741	lytic transglycosylase activity
BTL46_RS07510	COG0436	Aminotransferase
BTL46_RS07520	COG0280	phosphate acetyltransferase
BTL46_RS07520	COG0281	malic enzyme
BTL46_RS07535	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BTL46_RS07540	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BTL46_RS07545	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BTL46_RS07550	COG0126	phosphoglycerate kinase activity
BTL46_RS07565	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BTL46_RS07580	COG0625	glutathione transferase activity
BTL46_RS07600	COG0789	Transcriptional regulator
BTL46_RS07615	COG0306	phosphate transporter
BTL46_RS07620	COG0521	Mo-molybdopterin cofactor biosynthetic process
BTL46_RS07630	COG0739	heme binding
BTL46_RS07640	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BTL46_RS07680	COG0456	acetyltransferase
BTL46_RS07685	COG1301	dicarboxylic acid transport
BTL46_RS07695	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
BTL46_RS07700	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BTL46_RS07705	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BTL46_RS07710	COG0009	L-threonylcarbamoyladenylate synthase
BTL46_RS07720	COG4771	TonB-dependent receptor
BTL46_RS07750	COG1960	acyl-CoA dehydrogenase activity
BTL46_RS07755	COG0028	Belongs to the TPP enzyme family
BTL46_RS07760	COG0583	DNA-binding transcription factor activity
BTL46_RS07765	COG4974	Belongs to the 'phage' integrase family
BTL46_RS07770	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BTL46_RS07775	COG1686	Belongs to the peptidase S11 family
BTL46_RS07805	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BTL46_RS07810	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BTL46_RS07815	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BTL46_RS07835	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BTL46_RS07840	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BTL46_RS07845	COG0505	Belongs to the CarA family
BTL46_RS07850	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BTL46_RS07860	COG1028	Short-chain dehydrogenase reductase Sdr
BTL46_RS07865	COG0406	alpha-ribazole phosphatase activity
BTL46_RS07895	COG2233	PERMEase
BTL46_RS07900	COG3620	sequence-specific DNA binding
BTL46_RS07915	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BTL46_RS07925	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
BTL46_RS07930	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BTL46_RS07940	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BTL46_RS07955	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BTL46_RS07975	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BTL46_RS08035	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BTL46_RS08070	COG0540	Belongs to the ATCase OTCase family
BTL46_RS08075	COG2974	May be involved in recombination
BTL46_RS08100	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BTL46_RS08105	COG2137	regulation of response to DNA damage stimulus
BTL46_RS08115	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BTL46_RS08135	COG0045	succinate-CoA ligase (ADP-forming) activity
BTL46_RS08140	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BTL46_RS08145	COG0861	Integral membrane protein TerC family
BTL46_RS08150	COG0861	Integral membrane protein TerC family
BTL46_RS08155	COG0181	hydroxymethylbilane synthase activity
BTL46_RS08195	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BTL46_RS08240	COG1450	Type ii and iii secretion system protein
BTL46_RS08285	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BTL46_RS08295	COG1295	ribonuclease BN
BTL46_RS08305	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
BTL46_RS08325	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BTL46_RS08330	COG0501	Belongs to the peptidase M48B family
BTL46_RS08335	COG2197	response regulator
BTL46_RS08360	COG0066	3-isopropylmalate dehydratase activity
BTL46_RS08375	COG0473	3-isopropylmalate dehydrogenase activity
BTL46_RS08380	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BTL46_RS08390	COG0101	tRNA pseudouridine synthase activity
BTL46_RS08395	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
BTL46_RS08400	COG0135	phosphoribosylanthranilate isomerase activity
BTL46_RS08420	COG2801	Transposase and inactivated derivatives
BTL46_RS08425	COG2801	Transposase and inactivated derivatives
BTL46_RS08460	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BTL46_RS08465	COG2197	response regulator
BTL46_RS08470	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BTL46_RS08475	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BTL46_RS08490	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BTL46_RS08495	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BTL46_RS08505	COG1764	response to oxidative stress
BTL46_RS08520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BTL46_RS08525	COG0765	amino acid transport
BTL46_RS08530	COG0765	amino acid transport
BTL46_RS08535	COG1126	abc transporter atp-binding protein
BTL46_RS08540	COG0756	dUTP diphosphatase activity
BTL46_RS08570	COG1522	sequence-specific DNA binding
BTL46_RS08590	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BTL46_RS08595	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BTL46_RS08600	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BTL46_RS08605	COG0196	riboflavin kinase activity
BTL46_RS08615	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BTL46_RS08615	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BTL46_RS08645	COG0210	DNA helicase
BTL46_RS08650	COG4771	TonB-dependent receptor
BTL46_RS08660	COG2890	protein-(glutamine-N5) methyltransferase activity
BTL46_RS08665	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BTL46_RS08670	COG2171	N-acyltransferase activity
BTL46_RS08725	COG2801	Transposase and inactivated derivatives
BTL46_RS08770	COG2814	Major facilitator Superfamily
BTL46_RS08795	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BTL46_RS08800	COG2900	Belongs to the SlyX family
BTL46_RS08815	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BTL46_RS08835	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BTL46_RS08860	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BTL46_RS08865	COG0583	DNA-binding transcription factor activity
BTL46_RS08870	COG1028	Short-chain dehydrogenase reductase Sdr
BTL46_RS08880	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BTL46_RS08885	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BTL46_RS08895	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BTL46_RS08900	COG0508	dehydrogenase complex catalyzes the overall conversion of
BTL46_RS08905	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
BTL46_RS08915	COG4566	intracellular signal transduction
BTL46_RS08920	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BTL46_RS08940	COG1999	signal sequence binding
BTL46_RS08960	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BTL46_RS08965	COG0583	DNA-binding transcription factor activity
BTL46_RS08970	COG1187	pseudouridine synthase activity
BTL46_RS08975	COG3161	chorismate lyase activity
BTL46_RS08990	COG1280	lysine exporter protein (LysE YggA)
BTL46_RS09025	COG1129	ABC transporter
BTL46_RS09040	COG0583	DNA-binding transcription factor activity
BTL46_RS09070	COG1185	polyribonucleotide nucleotidyltransferase activity
BTL46_RS09075	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BTL46_RS09090	COG1183	phosphatidylcholine synthase activity
BTL46_RS09100	COG0440	acetolactate synthase activity
BTL46_RS09105	COG0028	Belongs to the TPP enzyme family
BTL46_RS09130	COG3022	response to hydroperoxide
BTL46_RS09140	COG1028	Short-chain dehydrogenase reductase Sdr
BTL46_RS09155	COG3486	L-lysine 6-monooxygenase (NADPH) activity
BTL46_RS09185	COG2814	Major facilitator Superfamily
BTL46_RS09215	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BTL46_RS09250	COG2733	membrane
BTL46_RS09270	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
BTL46_RS09290	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BTL46_RS09295	COG1129	ABC transporter
BTL46_RS09295	COG0842	Transport permease protein
BTL46_RS09300	COG0842	Transport permease protein
BTL46_RS09310	COG1028	Short-chain dehydrogenase reductase Sdr
BTL46_RS09320	COG2259	Doxx family
BTL46_RS09350	COG0415	Belongs to the DNA photolyase family
BTL46_RS09370	COG0386	Belongs to the glutathione peroxidase family
BTL46_RS09385	COG0095	Lipoate-protein ligase
BTL46_RS09395	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BTL46_RS09405	COG0010	Belongs to the arginase family
BTL46_RS09415	COG0765	amino acid transport
BTL46_RS09420	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BTL46_RS09435	COG0084	hydrolase, TatD family'
BTL46_RS09445	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BTL46_RS09450	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BTL46_RS09460	COG2175	clavaminate synthase activity
BTL46_RS09465	COG0583	DNA-binding transcription factor activity
BTL46_RS09490	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
BTL46_RS09505	COG2914	Belongs to the UPF0125 (RnfH) family
BTL46_RS09515	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BTL46_RS09545	COG0519	Catalyzes the synthesis of GMP from XMP
BTL46_RS09545	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BTL46_RS09555	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
BTL46_RS09565	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BTL46_RS09570	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BTL46_RS09575	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BTL46_RS09585	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BTL46_RS09590	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BTL46_RS09600	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BTL46_RS09605	COG0750	zinc metalloprotease
BTL46_RS09610	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
BTL46_RS09620	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BTL46_RS09625	COG0233	cytoplasmic translational termination
BTL46_RS09630	COG0528	UMP kinase activity
BTL46_RS09635	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BTL46_RS09640	COG0052	Belongs to the universal ribosomal protein uS2 family
BTL46_RS09645	COG0024	Methionine aminopeptidase
BTL46_RS09650	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
BTL46_RS09675	COG1286	toxin biosynthetic process
BTL46_RS09685	COG0285	dihydrofolate synthase activity
BTL46_RS09695	COG3181	Tripartite tricarboxylate transporter family receptor
BTL46_RS09700	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BTL46_RS09740	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BTL46_RS09750	COG1677	Flagellar hook-basal body complex protein FliE
BTL46_RS09760	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BTL46_RS09765	COG1317	bacterial-type flagellum organization
BTL46_RS09785	COG1580	Controls the rotational direction of flagella during chemotaxis
BTL46_RS09795	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BTL46_RS09820	COG0840	transmembrane signaling receptor activity
BTL46_RS09825	COG0840	transmembrane signaling receptor activity
BTL46_RS09850	COG1191	sigma factor activity
BTL46_RS09890	COG2199	diguanylate cyclase activity
BTL46_RS09890	COG2203	Gaf domain
BTL46_RS09900	COG1619	proteins homologs of microcin C7 resistance protein MccF
BTL46_RS09925	COG1126	abc transporter atp-binding protein
BTL46_RS09930	COG0765	amino acid transport
BTL46_RS09935	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BTL46_RS09980	COG2200	EAL domain
BTL46_RS10010	COG1253	flavin adenine dinucleotide binding
BTL46_RS10015	COG4251	negative regulation of phosphorylation
BTL46_RS10015	COG2203	Gaf domain
BTL46_RS10015	COG3706	GGDEF domain
BTL46_RS10015	COG5001	Diguanylate cyclase
BTL46_RS10025	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BTL46_RS10025	COG2205	protein histidine kinase activity
BTL46_RS10050	COG0076	glutamate decarboxylase activity
BTL46_RS10055	COG2985	domain, Protein
BTL46_RS10060	COG3189	MarR family transcriptional regulator
BTL46_RS10070	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BTL46_RS10080	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BTL46_RS10080	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BTL46_RS10090	COG0028	Belongs to the TPP enzyme family
BTL46_RS10100	COG1012	belongs to the aldehyde dehydrogenase family
BTL46_RS10110	COG0688	phosphatidylethanolamine metabolic process
BTL46_RS10115	COG1304	FMN binding
BTL46_RS10120	COG1464	Belongs to the NlpA lipoprotein family
BTL46_RS10140	COG0697	spore germination
BTL46_RS10145	COG2133	pyrroloquinoline quinone binding
BTL46_RS10150	COG0625	glutathione transferase activity
BTL46_RS10165	COG1794	racemase activity, acting on amino acids and derivatives
BTL46_RS10185	COG0559	Belongs to the binding-protein-dependent transport system permease family
BTL46_RS10195	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BTL46_RS10210	COG1175	transmembrane transport
BTL46_RS10215	COG0395	ABC-type sugar transport system, permease component
BTL46_RS10220	COG3842	ATPase activity
BTL46_RS10245	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
BTL46_RS10260	COG0438	transferase activity, transferring glycosyl groups
BTL46_RS10285	COG0463	Glycosyl transferase, family 2
BTL46_RS10300	COG0783	Belongs to the Dps family
BTL46_RS10305	COG0583	DNA-binding transcription factor activity
BTL46_RS10310	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BTL46_RS10340	COG1840	ABC-type Fe3 transport system, periplasmic component
BTL46_RS10350	COG3842	ATPase activity
BTL46_RS10355	COG1741	Belongs to the pirin family
BTL46_RS10360	COG1741	Belongs to the pirin family
BTL46_RS10365	COG0583	DNA-binding transcription factor activity
BTL46_RS10380	COG0174	glutamine synthetase
BTL46_RS10385	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BTL46_RS10390	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BTL46_RS10400	COG0840	transmembrane signaling receptor activity
BTL46_RS10415	COG0583	DNA-binding transcription factor activity
BTL46_RS10420	COG1960	acyl-CoA dehydrogenase activity
BTL46_RS10425	COG2079	MmgE PrpD family protein
BTL46_RS10435	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
BTL46_RS10440	COG1561	YicC-like family, N-terminal region
BTL46_RS10450	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BTL46_RS10455	COG0791	NLP P60 protein
BTL46_RS10460	COG1028	Short-chain dehydrogenase reductase Sdr
BTL46_RS10465	COG0194	GDP metabolic process
BTL46_RS10470	COG1758	RNA polymerase activity
BTL46_RS10475	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BTL46_RS10480	COG1126	abc transporter atp-binding protein
BTL46_RS10485	COG0765	amino acid transport
BTL46_RS10490	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BTL46_RS10500	COG2831	hemolysin activation secretion protein
BTL46_RS10510	COG3188	usher protein
BTL46_RS10515	COG3121	Chaperone
BTL46_RS10535	COG3064	Membrane
BTL46_RS10535	COG3210	domain, Protein
BTL46_RS10535	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
BTL46_RS10535	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
BTL46_RS10535	COG3210	domain, Protein
BTL46_RS10535	COG3064	Membrane
BTL46_RS10545	COG4181	ATPase activity
BTL46_RS10555	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BTL46_RS10560	COG0584	glycerophosphoryl diester phosphodiesterase
BTL46_RS10565	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
BTL46_RS10575	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
BTL46_RS10575	COG0678	peroxiredoxin activity
BTL46_RS10585	COG2217	Heavy metal translocating P-type atpase
BTL46_RS10590	COG0789	Transcriptional regulator
BTL46_RS10595	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BTL46_RS10630	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BTL46_RS10640	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
BTL46_RS10665	COG0583	DNA-binding transcription factor activity
BTL46_RS10670	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BTL46_RS10675	COG2252	PERMEase
BTL46_RS10680	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BTL46_RS10685	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BTL46_RS10720	COG0488	(ABC) transporter
BTL46_RS10725	COG1619	proteins homologs of microcin C7 resistance protein MccF
BTL46_RS10730	COG0590	tRNA wobble adenosine to inosine editing
BTL46_RS10745	COG1320	monovalent cation:proton antiporter activity
BTL46_RS10750	COG2212	antiporter activity
BTL46_RS10755	COG1863	multisubunit Na H antiporter MnhE subunit
BTL46_RS10760	COG0651	ATP synthesis coupled electron transport
BTL46_RS10765	COG1006	Multisubunit Na H antiporter MnhC subunit
BTL46_RS10770	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BTL46_RS10770	COG2111	Na H antiporter
BTL46_RS10775	COG3181	Tripartite tricarboxylate transporter family receptor
BTL46_RS10800	COG0420	3'-5' exonuclease activity
BTL46_RS10835	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BTL46_RS10845	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
BTL46_RS10855	COG2130	NADP-dependent
BTL46_RS10860	COG1309	transcriptional regulator
BTL46_RS10870	COG1131	(ABC) transporter
BTL46_RS10875	COG0842	Transport permease protein
BTL46_RS10885	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BTL46_RS10920	COG0602	queuosine metabolic process
BTL46_RS10925	COG0720	synthase
BTL46_RS10960	COG0587	DNA-directed DNA polymerase activity
BTL46_RS10970	COG0390	transport system, permease component
BTL46_RS10975	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BTL46_RS10980	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
BTL46_RS11035	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BTL46_RS11060	COG5507	3-demethylubiquinone-9 3-methyltransferase
BTL46_RS11095	COG1396	sequence-specific DNA binding
BTL46_RS11115	COG2801	Transposase and inactivated derivatives
BTL46_RS11135	COG0583	DNA-binding transcription factor activity
BTL46_RS11140	COG2814	Major facilitator Superfamily
BTL46_RS11165	COG2807	transmembrane transport
BTL46_RS11170	COG2207	Transcriptional regulator
BTL46_RS11175	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BTL46_RS11180	COG2814	Major facilitator Superfamily
BTL46_RS11195	COG1012	belongs to the aldehyde dehydrogenase family
BTL46_RS11230	COG0583	DNA-binding transcription factor activity
BTL46_RS11250	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BTL46_RS11275	COG0384	phenazine biosynthesis protein PhzF
BTL46_RS11280	COG1733	regulation of RNA biosynthetic process
BTL46_RS11315	COG3177	Filamentation induced by cAMP protein fic
BTL46_RS11325	COG0519	Catalyzes the synthesis of GMP from XMP
BTL46_RS11325	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BTL46_RS11340	COG1695	Transcriptional regulator
BTL46_RS11355	COG2072	flavoprotein involved in K transport
BTL46_RS11360	COG0601	transmembrane transport
BTL46_RS11380	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BTL46_RS11390	COG4608	Belongs to the ABC transporter superfamily
BTL46_RS11395	COG0747	negative chemotaxis
BTL46_RS11435	COG0047	phosphoribosylformylglycinamidine synthase activity
BTL46_RS11435	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BTL46_RS11440	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BTL46_RS11460	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BTL46_RS11460	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BTL46_RS11465	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BTL46_RS11475	COG0613	PHP domain protein
BTL46_RS11535	COG1012	belongs to the aldehyde dehydrogenase family
BTL46_RS11545	COG0583	DNA-binding transcription factor activity
BTL46_RS11565	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BTL46_RS11575	COG3181	Tripartite tricarboxylate transporter family receptor
BTL46_RS11585	COG3181	Tripartite tricarboxylate transporter family receptor
BTL46_RS11615	COG1595	DNA-templated transcription, initiation
BTL46_RS11620	COG3712	iron ion homeostasis
BTL46_RS11630	COG0084	hydrolase, TatD family'
BTL46_RS11635	COG1136	(ABC) transporter
BTL46_RS11650	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BTL46_RS11660	COG1028	Short-chain dehydrogenase reductase Sdr
BTL46_RS11665	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BTL46_RS11675	COG1803	Methylglyoxal synthase
BTL46_RS11695	COG2801	Transposase and inactivated derivatives
BTL46_RS11700	COG2801	Transposase and inactivated derivatives
BTL46_RS11725	COG2975	iron-sulfur cluster assembly
BTL46_RS11730	COG0633	Ferredoxin
BTL46_RS11735	COG0443	Heat shock 70 kDa protein
BTL46_RS11740	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
BTL46_RS11745	COG0316	Belongs to the HesB IscA family
BTL46_RS11750	COG0822	iron-sulfur transferase activity
BTL46_RS11755	COG1104	cysteine desulfurase activity
BTL46_RS11765	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BTL46_RS11770	COG0556	nucleotide-excision repair
BTL46_RS11785	COG0583	DNA-binding transcription factor activity
BTL46_RS11805	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BTL46_RS11845	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BTL46_RS11860	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BTL46_RS11870	COG0740	serine-type endopeptidase activity
BTL46_RS11875	COG0544	peptidyl-prolyl cis-trans isomerase activity
BTL46_RS11915	COG2801	Transposase and inactivated derivatives
BTL46_RS11925	COG1278	Cold shock
BTL46_RS11955	COG2433	Pfam Transposase IS66
BTL46_RS12015	COG1530	ribonuclease E activity
BTL46_RS12045	COG1846	Transcriptional regulator
BTL46_RS12055	COG1566	PFAM secretion protein HlyD family protein
BTL46_RS12060	COG2814	Major facilitator Superfamily
BTL46_RS12065	COG0473	3-isopropylmalate dehydrogenase activity
BTL46_RS12085	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BTL46_RS12090	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BTL46_RS12095	COG0433	COG0433 Predicted ATPase
BTL46_RS12100	COG0217	transcriptional regulatory protein
BTL46_RS12105	COG0151	Belongs to the GarS family
BTL46_RS12115	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BTL46_RS12120	COG0799	negative regulation of ribosome biogenesis
BTL46_RS12125	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BTL46_RS12130	COG0424	maF-like protein
BTL46_RS12140	COG4191	Histidine kinase
BTL46_RS12145	COG2204	response regulator
BTL46_RS12170	COG0500	methyltransferase
BTL46_RS12185	COG0803	Belongs to the bacterial solute-binding protein 9 family
BTL46_RS12190	COG1121	(ABC) transporter
BTL46_RS12195	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BTL46_RS12200	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BTL46_RS12230	COG4993	Dehydrogenase
BTL46_RS12255	COG2814	Major facilitator Superfamily
BTL46_RS12275	COG0037	tRNA processing
BTL46_RS12280	COG0825	malonyl-CoA metabolic process
BTL46_RS12290	COG0215	cysteine-tRNA ligase activity
BTL46_RS12300	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BTL46_RS12305	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BTL46_RS12310	COG1968	undecaprenyl-diphosphatase activity
BTL46_RS12315	COG1253	flavin adenine dinucleotide binding
BTL46_RS12320	COG0483	inositol monophosphate 1-phosphatase activity
BTL46_RS12340	COG0668	transmembrane transport
BTL46_RS12365	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BTL46_RS12375	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
BTL46_RS12390	COG1802	Transcriptional regulator
BTL46_RS12410	COG3360	Dodecin
BTL46_RS12430	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BTL46_RS12435	COG2850	peptidyl-arginine hydroxylation
BTL46_RS12445	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
BTL46_RS12450	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BTL46_RS12455	COG1994	Peptidase M50
BTL46_RS12460	COG0009	L-threonylcarbamoyladenylate synthase
BTL46_RS12465	COG2321	neutral zinc metallopeptidase
BTL46_RS12485	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BTL46_RS12495	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BTL46_RS12505	COG2271	Major facilitator Superfamily
BTL46_RS12580	COG2199	diguanylate cyclase activity
BTL46_RS12580	COG2200	EAL domain
BTL46_RS12580	COG2202	Pas domain
BTL46_RS12585	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
BTL46_RS12605	COG1960	acyl-CoA dehydrogenase activity
BTL46_RS12610	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BTL46_RS12615	COG2186	Transcriptional regulator
BTL46_RS12640	COG1595	DNA-templated transcription, initiation
BTL46_RS12675	COG1028	Short-chain dehydrogenase reductase Sdr
BTL46_RS12690	COG0179	Fumarylacetoacetate (FAA) hydrolase
BTL46_RS12710	COG4604	ABC transporter, ATP-binding protein
BTL46_RS12715	COG4605	iron ion homeostasis
BTL46_RS12720	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BTL46_RS12725	COG4607	ABC-type enterochelin transport system periplasmic component
BTL46_RS12730	COG0438	transferase activity, transferring glycosyl groups
BTL46_RS12740	COG0149	triose-phosphate isomerase activity
BTL46_RS12745	COG4221	oxidoreductase activity
BTL46_RS12745	COG3321	synthase
BTL46_RS12745	COG0604	alcohol dehydrogenase
BTL46_RS12745	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BTL46_RS12775	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BTL46_RS12775	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BTL46_RS12780	COG0668	transmembrane transport
BTL46_RS12785	COG0165	Argininosuccinate lyase
BTL46_RS12795	COG0789	Transcriptional regulator
BTL46_RS12805	COG0501	Belongs to the peptidase M48B family
BTL46_RS12810	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BTL46_RS12835	COG1024	Enoyl-CoA hydratase
BTL46_RS12840	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BTL46_RS12860	COG3468	outer membrane autotransporter barrel domain protein
BTL46_RS12900	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BTL46_RS12905	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BTL46_RS12910	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
BTL46_RS12915	COG1674	ftsk spoiiie
BTL46_RS12920	COG0492	ferredoxin-NADP+ reductase activity
BTL46_RS12925	COG1193	negative regulation of DNA recombination
BTL46_RS12940	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BTL46_RS12955	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
BTL46_RS12960	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
BTL46_RS12965	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
BTL46_RS12975	COG0745	RESPONSE REGULATOR receiver
BTL46_RS13010	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BTL46_RS13030	COG0612	Peptidase, M16
BTL46_RS13035	COG0484	heat shock protein binding
BTL46_RS13040	COG0443	Heat shock 70 kDa protein
BTL46_RS13050	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BTL46_RS13060	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
BTL46_RS13065	COG1420	regulation of RNA biosynthetic process
BTL46_RS13070	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BTL46_RS13075	COG0497	DNA recombination
BTL46_RS13105	COG0735	belongs to the Fur family
BTL46_RS13110	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BTL46_RS13155	COG2828	Protein conserved in bacteria
BTL46_RS13160	COG1280	lysine exporter protein (LysE YggA)
BTL46_RS13165	COG3181	Tripartite tricarboxylate transporter family receptor
BTL46_RS13185	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
BTL46_RS13190	COG1802	Transcriptional regulator
BTL46_RS13195	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
BTL46_RS13200	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BTL46_RS13205	COG1335	isochorismatase
BTL46_RS13210	COG0523	cobalamin synthesis protein
BTL46_RS13240	COG0583	DNA-binding transcription factor activity
BTL46_RS13250	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
BTL46_RS13255	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
BTL46_RS13260	COG0167	dihydroorotate dehydrogenase activity
BTL46_RS13305	COG4783	chaperone-mediated protein folding
BTL46_RS13310	COG0429	hydrolase of the alpha beta-hydrolase fold
BTL46_RS13335	COG0513	Belongs to the DEAD box helicase family
BTL46_RS13355	COG1414	Transcriptional regulator
BTL46_RS13400	COG0006	proline dipeptidase activity
BTL46_RS13410	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BTL46_RS13435	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
BTL46_RS13440	COG0632	four-way junction helicase activity
BTL46_RS13455	COG2255	four-way junction helicase activity
BTL46_RS13460	COG0514	ATP-dependent DNA helicase (RecQ)
BTL46_RS13480	COG1294	oxidase, subunit
BTL46_RS13490	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BTL46_RS13495	COG0850	regulation of cytokinetic process
BTL46_RS13500	COG2894	cell division
BTL46_RS13505	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
BTL46_RS13530	COG0488	(ABC) transporter
BTL46_RS13545	COG4608	Belongs to the ABC transporter superfamily
BTL46_RS13550	COG0444	Belongs to the ABC transporter superfamily
BTL46_RS13555	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BTL46_RS13570	COG1215	transferase activity, transferring glycosyl groups
BTL46_RS13575	COG0583	DNA-binding transcription factor activity
BTL46_RS13580	COG1368	sulfuric ester hydrolase activity
BTL46_RS13585	COG1686	Belongs to the peptidase S11 family
BTL46_RS13595	COG1280	lysine exporter protein (LysE YggA)
BTL46_RS13605	COG1064	alcohol dehydrogenase
BTL46_RS13610	COG4191	Histidine kinase
BTL46_RS13615	COG4566	intracellular signal transduction
BTL46_RS13625	COG1802	Transcriptional regulator
BTL46_RS13650	COG3181	Tripartite tricarboxylate transporter family receptor
BTL46_RS13655	COG0513	Belongs to the DEAD box helicase family
BTL46_RS13660	COG0668	transmembrane transport
BTL46_RS13675	COG1595	DNA-templated transcription, initiation
BTL46_RS13715	COG0583	DNA-binding transcription factor activity
BTL46_RS13720	COG0531	amino acid
BTL46_RS13725	COG1982	Orn Lys Arg decarboxylase major
BTL46_RS13750	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BTL46_RS13755	COG0459	protein refolding
BTL46_RS13765	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
BTL46_RS13770	COG1252	NADH dehydrogenase
BTL46_RS13775	COG0284	orotidine-5'-phosphate decarboxylase activity
BTL46_RS13785	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BTL46_RS13795	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BTL46_RS13800	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BTL46_RS13830	COG1595	DNA-templated transcription, initiation
BTL46_RS13840	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
BTL46_RS13845	COG3639	organic phosphonate transmembrane transporter activity
BTL46_RS13850	COG3639	organic phosphonate transmembrane transporter activity
BTL46_RS13865	COG0742	ribosomal rna small subunit methyltransferase
BTL46_RS13870	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BTL46_RS13875	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
BTL46_RS13880	COG3135	benzoate transporter
BTL46_RS13900	COG4774	siderophore transport
BTL46_RS13925	COG1024	Enoyl-CoA hydratase
BTL46_RS13930	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BTL46_RS13935	COG1960	acyl-CoA dehydrogenase activity
BTL46_RS13945	COG0318	PFAM AMP-dependent synthetase and ligase
BTL46_RS13950	COG3181	Tripartite tricarboxylate transporter family receptor
BTL46_RS13960	COG0583	DNA-binding transcription factor activity
BTL46_RS13985	COG0277	FAD linked oxidase domain protein
BTL46_RS14005	COG1802	Transcriptional regulator
BTL46_RS14015	COG2271	Major facilitator Superfamily
BTL46_RS14025	COG0583	DNA-binding transcription factor activity
BTL46_RS14050	COG0012	GTP binding
BTL46_RS14060	COG0193	aminoacyl-tRNA hydrolase activity
BTL46_RS14065	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
BTL46_RS14070	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BTL46_RS14080	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BTL46_RS14095	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BTL46_RS14120	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
BTL46_RS14130	COG1368	sulfuric ester hydrolase activity
BTL46_RS14135	COG2186	Transcriptional regulator
BTL46_RS14145	COG3181	Tripartite tricarboxylate transporter family receptor
BTL46_RS14160	COG0277	FAD linked oxidase domain protein
BTL46_RS14175	COG0166	Belongs to the GPI family
BTL46_RS14180	COG0438	transferase activity, transferring glycosyl groups
BTL46_RS14185	COG0438	transferase activity, transferring glycosyl groups
BTL46_RS14200	COG0438	transferase activity, transferring glycosyl groups
BTL46_RS14215	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
BTL46_RS14220	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BTL46_RS14225	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
BTL46_RS14235	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BTL46_RS14245	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BTL46_RS14250	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BTL46_RS14265	COG0747	negative chemotaxis
BTL46_RS14275	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BTL46_RS14280	COG4172	Belongs to the ABC transporter superfamily
BTL46_RS14300	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BTL46_RS14300	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BTL46_RS14305	COG0509	glycine decarboxylation via glycine cleavage system
BTL46_RS14310	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BTL46_RS14315	COG2081	HI0933 family
BTL46_RS14330	COG0456	acetyltransferase
BTL46_RS14335	COG0717	Belongs to the dCTP deaminase family
BTL46_RS14350	COG0489	protein tyrosine kinase activity
BTL46_RS14360	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BTL46_RS14360	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BTL46_RS14385	COG3539	Fimbrial protein
BTL46_RS14400	COG0745	RESPONSE REGULATOR receiver
BTL46_RS14425	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
BTL46_RS14440	COG2084	Dehydrogenase
BTL46_RS14445	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BTL46_RS14470	COG3842	ATPase activity
BTL46_RS14475	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
BTL46_RS14480	COG1960	acyl-CoA dehydrogenase activity
BTL46_RS14490	COG0583	DNA-binding transcription factor activity
BTL46_RS14500	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BTL46_RS14505	COG1024	Enoyl-CoA hydratase
BTL46_RS14520	COG0583	DNA-binding transcription factor activity
BTL46_RS14525	COG1408	metallophosphoesterase
BTL46_RS14530	COG0625	glutathione transferase activity
BTL46_RS14565	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BTL46_RS14565	COG0426	domain, Protein
BTL46_RS14570	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BTL46_RS14575	COG0583	DNA-binding transcription factor activity
BTL46_RS14585	COG1024	Enoyl-CoA hydratase
BTL46_RS14595	COG1960	acyl-CoA dehydrogenase activity
BTL46_RS14600	COG1028	Short-chain dehydrogenase reductase Sdr
BTL46_RS14605	COG1028	Short-chain dehydrogenase reductase Sdr
BTL46_RS14625	COG3181	Tripartite tricarboxylate transporter family receptor
BTL46_RS14630	COG1028	Short-chain dehydrogenase reductase Sdr
BTL46_RS14640	COG3181	Tripartite tricarboxylate transporter family receptor
BTL46_RS14680	COG0583	DNA-binding transcription factor activity
BTL46_RS14685	COG1960	acyl-CoA dehydrogenase activity
BTL46_RS14690	COG3181	Tripartite tricarboxylate transporter family receptor
BTL46_RS14695	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BTL46_RS14700	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BTL46_RS14725	COG0560	Phosphoserine phosphatase
BTL46_RS14730	COG0583	DNA-binding transcription factor activity
BTL46_RS14745	COG3842	ATPase activity
BTL46_RS14760	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BTL46_RS14780	COG0625	glutathione transferase activity
BTL46_RS14825	COG4336	lyase activity
BTL46_RS14835	COG0326	Molecular chaperone. Has ATPase activity
BTL46_RS14840	COG2233	PERMEase
BTL46_RS14880	COG2818	Glycosylase
BTL46_RS14885	COG0727	PFAM Uncharacterised protein family (UPF0153)
BTL46_RS14910	COG0402	S-adenosylhomocysteine deaminase activity
BTL46_RS14920	COG0156	8-amino-7-oxononanoate synthase activity
BTL46_RS14925	COG2877	3-deoxy-8-phosphooctulonate synthase activity
BTL46_RS14975	COG1464	Belongs to the NlpA lipoprotein family
BTL46_RS14980	COG2011	ABC-type metal ion transport system permease component
BTL46_RS14985	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BTL46_RS14990	COG1501	Belongs to the glycosyl hydrolase 31 family
BTL46_RS14995	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
BTL46_RS14995	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BTL46_RS15000	COG0483	inositol monophosphate 1-phosphatase activity
BTL46_RS15005	COG0318	PFAM AMP-dependent synthetase and ligase
BTL46_RS15010	COG1473	amidohydrolase
BTL46_RS15015	COG0583	DNA-binding transcription factor activity
BTL46_RS15020	COG2855	membrane
BTL46_RS15030	COG2239	Acts as a magnesium transporter
BTL46_RS15045	COG1522	sequence-specific DNA binding
BTL46_RS15085	COG0330	HflC and HflK could
BTL46_RS15090	COG0330	HflC and HflK could
BTL46_RS15095	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BTL46_RS15100	COG1923	regulation of RNA biosynthetic process
BTL46_RS15110	COG1160	GTP binding
BTL46_RS15115	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BTL46_RS15120	COG2976	Protein conserved in bacteria
BTL46_RS15125	COG0124	histidyl-tRNA synthetase
BTL46_RS15140	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BTL46_RS15145	COG0105	UTP biosynthetic process
BTL46_RS15150	COG0525	valine-tRNA ligase activity
BTL46_RS15160	COG0336	Belongs to the RNA methyltransferase TrmD family
BTL46_RS15165	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BTL46_RS15170	COG0228	four-way junction DNA binding
BTL46_RS15175	COG0425	Belongs to the sulfur carrier protein TusA family
BTL46_RS15180	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BTL46_RS15245	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BTL46_RS15250	COG0543	2 iron, 2 sulfur cluster binding
BTL46_RS15250	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BTL46_RS15255	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
BTL46_RS15260	COG2076	Multidrug Resistance protein
BTL46_RS15265	COG3217	Mosc domain protein beta barrel domain protein
BTL46_RS15265	COG0633	Ferredoxin
BTL46_RS15270	COG5285	phytanoyl-CoA dioxygenase
BTL46_RS15275	COG0662	Cupin 2, conserved barrel domain protein
BTL46_RS15285	COG0456	acetyltransferase
BTL46_RS15305	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BTL46_RS15335	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BTL46_RS15360	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
BTL46_RS15365	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BTL46_RS15370	COG1760	l-serine dehydratase
BTL46_RS15375	COG1283	sodium-dependent phosphate transmembrane transporter activity
BTL46_RS15380	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BTL46_RS15385	COG0412	Dienelactone hydrolase
BTL46_RS15390	COG0428	transporter
BTL46_RS15400	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BTL46_RS15405	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BTL46_RS15410	COG1845	cytochrome c oxidase, subunit III
BTL46_RS15415	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
BTL46_RS15425	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BTL46_RS15425	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BTL46_RS15450	COG1942	4-Oxalocrotonate Tautomerase
BTL46_RS15460	COG4176	ABC-type proline glycine betaine transport system permease component
BTL46_RS15480	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BTL46_RS15485	COG2814	Major facilitator Superfamily
BTL46_RS15490	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BTL46_RS15495	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BTL46_RS15520	COG1846	Transcriptional regulator
BTL46_RS15525	COG2814	Major facilitator Superfamily
BTL46_RS15530	COG0495	leucyl-tRNA aminoacylation
BTL46_RS15545	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BTL46_RS15565	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BTL46_RS15570	COG2274	protein secretion by the type I secretion system
BTL46_RS15615	COG0427	acetyl-CoA hydrolase
BTL46_RS15625	COG1511	domain protein
BTL46_RS15625	COG3264	Mechanosensitive ion channel
BTL46_RS15630	COG0730	response to heat
BTL46_RS15645	COG2176	DNA-directed DNA polymerase activity
BTL46_RS15665	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
BTL46_RS15670	COG3384	dioxygenase
BTL46_RS15685	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BTL46_RS15755	COG4964	Belongs to the GSP D family
BTL46_RS15800	COG1846	Transcriptional regulator
BTL46_RS15835	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
BTL46_RS15845	COG2070	2-Nitropropane dioxygenase
BTL46_RS15850	COG2070	2-Nitropropane dioxygenase
BTL46_RS15860	COG2610	gluconate transmembrane transporter activity
BTL46_RS15875	COG1408	metallophosphoesterase
BTL46_RS15880	COG0493	'glutamate synthase
BTL46_RS15880	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
BTL46_RS15885	COG2199	diguanylate cyclase activity
BTL46_RS15890	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
BTL46_RS15925	COG2159	amidohydrolase
BTL46_RS15960	COG1024	Enoyl-CoA hydratase
BTL46_RS15965	COG2186	Transcriptional regulator
BTL46_RS15970	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BTL46_RS15980	COG0833	amino acid
BTL46_RS15990	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
BTL46_RS16025	COG5265	(ABC) transporter
BTL46_RS16065	COG1971	Probably functions as a manganese efflux pump
BTL46_RS16070	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BTL46_RS16080	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BTL46_RS16085	COG2814	Major facilitator Superfamily
BTL46_RS16115	COG0747	negative chemotaxis
BTL46_RS16125	COG0625	glutathione transferase activity
BTL46_RS16155	COG1595	DNA-templated transcription, initiation
BTL46_RS16165	COG4774	siderophore transport
BTL46_RS16180	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BTL46_RS16195	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
BTL46_RS16200	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
BTL46_RS16225	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BTL46_RS16230	COG1024	Enoyl-CoA hydratase
BTL46_RS16265	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BTL46_RS16270	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BTL46_RS16275	COG1116	anion transmembrane transporter activity
BTL46_RS16285	COG3585	molybdate ion transport
BTL46_RS16345	COG0583	DNA-binding transcription factor activity
BTL46_RS16350	COG4948	Mandelate Racemase Muconate Lactonizing
BTL46_RS16355	COG3181	Tripartite tricarboxylate transporter family receptor
BTL46_RS16380	COG3181	Tripartite tricarboxylate transporter family receptor
BTL46_RS16385	COG3181	Tripartite tricarboxylate transporter family receptor
BTL46_RS16420	COG4177	L-phenylalanine transmembrane transporter activity
BTL46_RS16445	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BTL46_RS16460	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BTL46_RS16465	COG1538	Outer membrane efflux protein
BTL46_RS16470	COG0577	efflux transmembrane transporter activity
BTL46_RS16470	COG1136	(ABC) transporter
BTL46_RS16475	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BTL46_RS16490	COG0259	pyridoxamine-phosphate oxidase activity
BTL46_RS16495	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BTL46_RS16500	COG0579	oxidoreductase
BTL46_RS16510	COG0405	Gamma-glutamyltransferase
BTL46_RS16520	COG3181	Tripartite tricarboxylate transporter family receptor
BTL46_RS16530	COG0114	fumarate hydratase activity
BTL46_RS16535	COG0802	atpase or kinase
BTL46_RS16540	COG0860	N-Acetylmuramoyl-L-alanine amidase
BTL46_RS16545	COG0586	Pfam SNARE associated Golgi protein
BTL46_RS16550	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BTL46_RS16555	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BTL46_RS16560	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BTL46_RS16575	COG0617	tRNA 3'-terminal CCA addition
BTL46_RS16610	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
BTL46_RS16620	COG1024	Enoyl-CoA hydratase
BTL46_RS16630	COG2188	Transcriptional regulator
BTL46_RS16635	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BTL46_RS16650	COG0752	glycyl-tRNA synthetase alpha subunit
BTL46_RS16655	COG0751	glycine-tRNA ligase activity
BTL46_RS16660	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
BTL46_RS16665	COG0204	Acyl-transferase
BTL46_RS16695	COG0242	peptide deformylase activity
BTL46_RS16705	COG0700	Nucleoside recognition
BTL46_RS16710	COG0469	pyruvate kinase activity
BTL46_RS16715	COG1929	Belongs to the glycerate kinase type-1 family
BTL46_RS16725	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BTL46_RS16730	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BTL46_RS16735	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
BTL46_RS16745	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
BTL46_RS16755	COG2154	pterin-4-alpha-carbinolamine dehydratase
BTL46_RS16760	COG2885	chlorophyll binding
BTL46_RS16770	COG0667	Aldo Keto reductase
BTL46_RS16780	COG3181	Tripartite tricarboxylate transporter family receptor
BTL46_RS16800	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BTL46_RS16805	COG0288	reversible hydration of carbon dioxide
BTL46_RS16825	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BTL46_RS16835	COG4829	muconolactone delta-isomerase
BTL46_RS16840	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
BTL46_RS16850	COG1414	Transcriptional regulator
BTL46_RS16855	COG1028	Short-chain dehydrogenase reductase Sdr
BTL46_RS16860	COG2031	fatty acid transporter
BTL46_RS16865	COG1250	3-hydroxyacyl-CoA dehydrogenase
BTL46_RS16875	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
BTL46_RS16880	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
BTL46_RS16895	COG0129	dihydroxy-acid dehydratase activity
BTL46_RS16900	COG1609	Transcriptional regulator
BTL46_RS16920	COG4106	trans-aconitate 2-methyltransferase activity
BTL46_RS16940	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BTL46_RS16980	COG0163	prenyltransferase activity
BTL46_RS16985	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BTL46_RS16990	COG2890	protein-(glutamine-N5) methyltransferase activity
BTL46_RS16995	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BTL46_RS17000	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
BTL46_RS17015	COG3712	iron ion homeostasis
BTL46_RS17045	COG0659	secondary active sulfate transmembrane transporter activity
BTL46_RS17065	COG1028	Short-chain dehydrogenase reductase Sdr
BTL46_RS17080	COG4774	siderophore transport
BTL46_RS17090	COG1595	DNA-templated transcription, initiation
BTL46_RS17105	COG0142	geranyltranstransferase activity
BTL46_RS17110	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BTL46_RS17115	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BTL46_RS17120	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BTL46_RS17125	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BTL46_RS17145	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BTL46_RS17145	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BTL46_RS17150	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
BTL46_RS17165	COG0583	DNA-binding transcription factor activity
BTL46_RS17170	COG0861	Integral membrane protein TerC family
BTL46_RS17185	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BTL46_RS17190	COG0793	Belongs to the peptidase S41A family
BTL46_RS17195	COG4942	peptidase
BTL46_RS17200	COG0588	phosphoglycerate mutase activity
BTL46_RS17210	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
BTL46_RS17215	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
BTL46_RS17220	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BTL46_RS17225	COG3181	Tripartite tricarboxylate transporter family receptor
BTL46_RS17240	COG2226	methyltransferase
BTL46_RS17245	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
BTL46_RS17250	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BTL46_RS17260	COG2204	response regulator
BTL46_RS17265	COG5000	phosphorelay sensor kinase activity
BTL46_RS17275	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BTL46_RS17275	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BTL46_RS17315	COG2188	Transcriptional regulator
BTL46_RS17330	COG0583	DNA-binding transcription factor activity
BTL46_RS17335	COG1012	belongs to the aldehyde dehydrogenase family
BTL46_RS17355	COG0546	phosphoglycolate phosphatase activity
BTL46_RS17370	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BTL46_RS17375	COG0242	peptide deformylase activity
BTL46_RS17385	COG1522	sequence-specific DNA binding
BTL46_RS17390	COG2879	small protein
BTL46_RS17395	COG1966	Carbon starvation protein
BTL46_RS17425	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BTL46_RS17430	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BTL46_RS17435	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BTL46_RS17440	COG3181	Tripartite tricarboxylate transporter family receptor
BTL46_RS17505	COG1172	Belongs to the binding-protein-dependent transport system permease family
BTL46_RS17540	COG0640	Transcriptional regulator
BTL46_RS17580	COG0735	belongs to the Fur family
BTL46_RS17585	COG2207	Transcriptional regulator
BTL46_RS17590	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BTL46_RS17595	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BTL46_RS17600	COG0513	Belongs to the DEAD box helicase family
BTL46_RS17630	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BTL46_RS17645	COG1305	Transglutaminase-like
BTL46_RS17685	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BTL46_RS17690	COG1950	PFAM Membrane protein of
BTL46_RS17715	COG0024	Methionine aminopeptidase
BTL46_RS17720	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BTL46_RS17730	COG1560	Kdo2-lipid A biosynthetic process
BTL46_RS17735	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BTL46_RS17745	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
BTL46_RS17780	COG0735	belongs to the Fur family
BTL46_RS17785	COG0523	cobalamin synthesis protein
BTL46_RS17800	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
BTL46_RS17810	COG2096	Adenosyltransferase
BTL46_RS17815	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BTL46_RS17820	COG0321	lipoyl(octanoyl) transferase activity
BTL46_RS17830	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BTL46_RS17835	COG1686	Belongs to the peptidase S11 family
BTL46_RS17860	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BTL46_RS17870	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
BTL46_RS17880	COG0859	PFAM glycosyl transferase family 9
BTL46_RS17915	COG0477	Major facilitator Superfamily
BTL46_RS17930	COG3568	Endonuclease Exonuclease Phosphatase
BTL46_RS17935	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BTL46_RS17965	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BTL46_RS17970	COG1956	GAF domain-containing protein
BTL46_RS17975	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BTL46_RS17990	COG2186	Transcriptional regulator
BTL46_RS17995	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
BTL46_RS18010	COG1840	ABC-type Fe3 transport system, periplasmic component
BTL46_RS18050	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BTL46_RS18055	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BTL46_RS18060	COG1086	Polysaccharide biosynthesis protein
BTL46_RS18095	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
BTL46_RS18105	COG1028	Short-chain dehydrogenase reductase Sdr
BTL46_RS18110	COG1012	belongs to the aldehyde dehydrogenase family
BTL46_RS18125	COG1522	sequence-specific DNA binding
BTL46_RS18130	COG3781	membrane
BTL46_RS18170	COG2200	EAL domain
BTL46_RS18180	COG0592	DNA-directed DNA polymerase activity
BTL46_RS18185	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BTL46_RS18190	COG0230	Belongs to the bacterial ribosomal protein bL34 family
BTL46_RS18195	COG0594	ribonuclease P activity
BTL46_RS18200	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
BTL46_RS18205	COG0706	membrane insertase activity
BTL46_RS18210	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
BTL46_RS18215	COG1473	amidohydrolase
BTL46_RS18220	COG4608	Belongs to the ABC transporter superfamily
BTL46_RS18225	COG0444	Belongs to the ABC transporter superfamily
BTL46_RS18230	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BTL46_RS18235	COG0601	transmembrane transport
BTL46_RS18245	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BTL46_RS18250	COG1505	serine-type exopeptidase activity
BTL46_RS18260	COG0281	malic enzyme
BTL46_RS18260	COG0280	phosphate acetyltransferase
BTL46_RS18290	COG0436	Aminotransferase
BTL46_RS18295	COG1278	Cold shock