locus-tag	class	description
BTL48_RS00005	COG0445	tRNA wobble uridine modification
BTL48_RS00010	COG0357	Ribosomal RNA small subunit methyltransferase G
BTL48_RS00015	COG1192	Involved in chromosome partitioning
BTL48_RS00020	COG1475	DNA binding
BTL48_RS00025	COG0252	asparaginase activity
BTL48_RS00045	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BTL48_RS00055	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BTL48_RS00065	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BTL48_RS00070	COG0081	regulation of translation
BTL48_RS00075	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BTL48_RS00080	COG0222	ribosome binding
BTL48_RS00085	COG0085	RNA polymerase activity
BTL48_RS00090	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BTL48_RS00125	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BTL48_RS00130	COG0049	tRNA binding
BTL48_RS00135	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BTL48_RS00140	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BTL48_RS00145	COG0051	transcription antitermination factor activity, RNA binding
BTL48_RS00150	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BTL48_RS00155	COG0088	Forms part of the polypeptide exit tunnel
BTL48_RS00160	COG0089	rRNA binding
BTL48_RS00165	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BTL48_RS00170	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BTL48_RS00175	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BTL48_RS00180	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BTL48_RS00185	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BTL48_RS00190	COG0255	Belongs to the universal ribosomal protein uL29 family
BTL48_RS00195	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BTL48_RS00215	COG1129	ABC transporter
BTL48_RS00220	COG0411	ABC transporter
BTL48_RS00250	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BTL48_RS00255	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BTL48_RS00260	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BTL48_RS00265	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BTL48_RS00270	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BTL48_RS00275	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BTL48_RS00280	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BTL48_RS00285	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BTL48_RS00290	COG1841	ribosomal large subunit assembly
BTL48_RS00295	COG0200	Binds to the 23S rRNA
BTL48_RS00300	COG0201	protein transport
BTL48_RS00305	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BTL48_RS00310	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BTL48_RS00315	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BTL48_RS00320	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BTL48_RS00325	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BTL48_RS00330	COG0202	RNA polymerase activity
BTL48_RS00335	COG0203	ribosomal protein L17
BTL48_RS00340	COG0537	adenosine 5'-monophosphoramidase activity
BTL48_RS00345	COG1324	tolerance protein
BTL48_RS00350	COG4232	protein-disulfide reductase activity
BTL48_RS00365	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BTL48_RS00375	COG1333	cytochrome c biogenesis protein
BTL48_RS00380	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BTL48_RS00395	COG1965	Belongs to the frataxin family
BTL48_RS00405	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BTL48_RS00410	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BTL48_RS00415	COG0232	Belongs to the dGTPase family. Type 2 subfamily
BTL48_RS00435	COG2814	Major facilitator Superfamily
BTL48_RS00480	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BTL48_RS00485	COG2922	Belongs to the Smg family
BTL48_RS00490	COG1629	transport
BTL48_RS00500	COG2358	TRAP transporter, solute receptor (TAXI family
BTL48_RS00510	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BTL48_RS00525	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BTL48_RS00530	COG0183	Belongs to the thiolase family
BTL48_RS00535	COG1960	acyl-CoA dehydrogenase activity
BTL48_RS00560	COG2200	EAL domain
BTL48_RS00565	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BTL48_RS00575	COG0018	arginyl-trna synthetase
BTL48_RS00590	COG0154	amidase activity
BTL48_RS00595	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BTL48_RS00605	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
BTL48_RS00615	COG0697	spore germination
BTL48_RS00675	COG3350	monooxygenase activity
BTL48_RS00700	COG1309	transcriptional regulator
BTL48_RS00730	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
BTL48_RS00735	COG1280	lysine exporter protein (LysE YggA)
BTL48_RS00740	COG0513	Belongs to the DEAD box helicase family
BTL48_RS00750	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
BTL48_RS00755	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BTL48_RS00785	COG2969	positive regulation of protein catabolic process
BTL48_RS00790	COG0625	glutathione transferase activity
BTL48_RS00795	COG2857	Cytochrome c1
BTL48_RS00800	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BTL48_RS00805	COG0723	plastoquinol--plastocyanin reductase activity
BTL48_RS00810	COG1970	mechanosensitive ion channel activity
BTL48_RS00815	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BTL48_RS00820	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BTL48_RS00830	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BTL48_RS00835	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BTL48_RS00845	COG0140	phosphoribosyl-ATP diphosphatase activity
BTL48_RS00850	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BTL48_RS00855	COG0107	imidazoleglycerol-phosphate synthase activity
BTL48_RS00860	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BTL48_RS00870	COG0131	Imidazoleglycerol-phosphate dehydratase
BTL48_RS00875	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BTL48_RS00880	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
BTL48_RS00885	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BTL48_RS00890	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BTL48_RS00900	COG0842	Transport permease protein
BTL48_RS00905	COG1131	(ABC) transporter
BTL48_RS00920	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BTL48_RS00925	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BTL48_RS00930	COG1127	ABC transporter
BTL48_RS00950	COG0069	glutamate synthase activity
BTL48_RS00950	COG0067	glutamate synthase
BTL48_RS00950	COG0070	glutamate synthase
BTL48_RS00975	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
BTL48_RS01000	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BTL48_RS01005	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
BTL48_RS01045	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BTL48_RS01080	COG0109	protoheme IX farnesyltransferase activity
BTL48_RS01085	COG1999	signal sequence binding
BTL48_RS01105	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BTL48_RS01110	COG2814	Major facilitator Superfamily
BTL48_RS01125	COG1522	sequence-specific DNA binding
BTL48_RS01185	COG4948	Mandelate Racemase Muconate Lactonizing
BTL48_RS01200	COG3119	arylsulfatase activity
BTL48_RS01240	COG0402	S-adenosylhomocysteine deaminase activity
BTL48_RS01250	COG1304	FMN binding
BTL48_RS01255	COG1254	Belongs to the acylphosphatase family
BTL48_RS01265	COG3181	Tripartite tricarboxylate transporter family receptor
BTL48_RS01275	COG1414	Transcriptional regulator
BTL48_RS01295	COG0028	Belongs to the TPP enzyme family
BTL48_RS01300	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
BTL48_RS01305	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BTL48_RS01310	COG1960	acyl-CoA dehydrogenase activity
BTL48_RS01345	COG3181	Tripartite tricarboxylate transporter family receptor
BTL48_RS01350	COG0583	DNA-binding transcription factor activity
BTL48_RS01365	COG0129	dihydroxy-acid dehydratase activity
BTL48_RS01370	COG2084	Dehydrogenase
BTL48_RS01385	COG1671	Belongs to the UPF0178 family
BTL48_RS01390	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
BTL48_RS01405	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
BTL48_RS01410	COG0443	Heat shock 70 kDa protein
BTL48_RS01435	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BTL48_RS01435	COG2169	Transcriptional regulator
BTL48_RS01450	COG1683	Conserved Protein
BTL48_RS01455	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BTL48_RS01470	COG1120	ATPase activity
BTL48_RS01475	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BTL48_RS01480	COG4558	Periplasmic binding protein
BTL48_RS01485	COG3720	iron ion transport
BTL48_RS01495	COG3712	iron ion homeostasis
BTL48_RS01500	COG1595	DNA-templated transcription, initiation
BTL48_RS01520	COG1607	acyl-coa hydrolase
BTL48_RS01530	COG0243	molybdopterin cofactor binding
BTL48_RS01530	COG3383	formate dehydrogenase (NAD+) activity
BTL48_RS01535	COG0243	molybdopterin cofactor binding
BTL48_RS01535	COG3383	formate dehydrogenase (NAD+) activity
BTL48_RS01540	COG0437	4 iron, 4 sulfur cluster binding
BTL48_RS01545	COG2864	formate dehydrogenase
BTL48_RS01560	COG3276	selenocysteine insertion sequence binding
BTL48_RS01595	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BTL48_RS01600	COG0512	Glutamine amidotransferase of anthranilate synthase
BTL48_RS01610	COG0546	phosphoglycolate phosphatase activity
BTL48_RS01615	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BTL48_RS01620	COG2967	ApaG domain
BTL48_RS01625	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
BTL48_RS01630	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BTL48_RS01635	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BTL48_RS01640	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BTL48_RS01645	COG0037	tRNA processing
BTL48_RS01665	COG1024	Enoyl-CoA hydratase
BTL48_RS01680	COG0356	it plays a direct role in the translocation of protons across the membrane
BTL48_RS01690	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BTL48_RS01695	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BTL48_RS01700	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BTL48_RS01705	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BTL48_RS01710	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BTL48_RS01715	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BTL48_RS01740	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
BTL48_RS01745	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BTL48_RS01750	COG0210	DNA helicase
BTL48_RS01765	COG4608	Belongs to the ABC transporter superfamily
BTL48_RS01770	COG0444	Belongs to the ABC transporter superfamily
BTL48_RS01775	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BTL48_RS01800	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BTL48_RS01805	COG1024	Enoyl-CoA hydratase
BTL48_RS01810	COG1024	Enoyl-CoA hydratase
BTL48_RS01815	COG2070	2-Nitropropane dioxygenase
BTL48_RS01830	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BTL48_RS01835	COG1250	3-hydroxyacyl-CoA dehydrogenase
BTL48_RS01855	COG2267	carboxylic ester hydrolase activity
BTL48_RS01875	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
BTL48_RS01885	COG2813	Specifically methylates the guanine in position
BTL48_RS01885	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BTL48_RS01890	COG2223	nitrite transmembrane transporter activity
BTL48_RS01895	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
BTL48_RS01910	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BTL48_RS01915	COG0708	Exodeoxyribonuclease III
BTL48_RS01920	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BTL48_RS01925	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BTL48_RS01930	COG0154	amidase activity
BTL48_RS01935	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BTL48_RS01940	COG1077	Cell shape determining protein MreB Mrl
BTL48_RS01945	COG1792	Involved in formation and maintenance of cell shape
BTL48_RS01955	COG0768	penicillin binding
BTL48_RS01960	COG0772	Belongs to the SEDS family
BTL48_RS01965	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
BTL48_RS01970	COG0471	metal ion transport
BTL48_RS01975	COG1309	transcriptional regulator
BTL48_RS01985	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BTL48_RS02000	COG2823	Periplasmic or secreted lipoprotein
BTL48_RS02005	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
BTL48_RS02010	COG0792	nuclease activity
BTL48_RS02030	COG1660	Displays ATPase and GTPase activities
BTL48_RS02045	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
BTL48_RS02055	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
BTL48_RS02065	COG3181	Tripartite tricarboxylate transporter family receptor
BTL48_RS02070	COG1473	amidohydrolase
BTL48_RS02075	COG1137	ATPase activity
BTL48_RS02090	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
BTL48_RS02100	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
BTL48_RS02120	COG1294	oxidase, subunit
BTL48_RS02130	COG4988	ABC transporter
BTL48_RS02135	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BTL48_RS02140	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BTL48_RS02155	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BTL48_RS02160	COG1238	metal cluster binding
BTL48_RS02180	COG1984	allophanate hydrolase subunit 2
BTL48_RS02185	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
BTL48_RS02195	COG0583	DNA-binding transcription factor activity
BTL48_RS02200	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BTL48_RS02205	COG5002	protein histidine kinase activity
BTL48_RS02210	COG0745	RESPONSE REGULATOR receiver
BTL48_RS02215	COG2226	methyltransferase
BTL48_RS02260	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BTL48_RS02270	COG1028	Short-chain dehydrogenase reductase Sdr
BTL48_RS02290	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BTL48_RS02295	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BTL48_RS02305	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BTL48_RS02325	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
BTL48_RS02330	COG1538	Outer membrane efflux protein
BTL48_RS02340	COG0351	phosphomethylpyrimidine kinase
BTL48_RS02345	COG2022	thiamine diphosphate biosynthetic process
BTL48_RS02350	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BTL48_RS02370	COG2226	methyltransferase
BTL48_RS02380	COG1194	a g-specific adenine glycosylase
BTL48_RS02390	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
BTL48_RS02395	COG2177	Part of the ABC transporter FtsEX involved in
BTL48_RS02400	COG2884	Cell division ATP-binding protein ftsE
BTL48_RS02405	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BTL48_RS02410	COG4597	amino acid ABC transporter
BTL48_RS02415	COG0765	amino acid transport
BTL48_RS02420	COG1126	abc transporter atp-binding protein
BTL48_RS02450	COG0477	Major facilitator Superfamily
BTL48_RS02460	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
BTL48_RS02465	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
BTL48_RS02480	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
BTL48_RS02485	COG0237	dephospho-CoA kinase activity
BTL48_RS02490	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
BTL48_RS02500	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BTL48_RS02515	COG3539	Fimbrial protein
BTL48_RS02520	COG3539	Fimbrial protein
BTL48_RS02535	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
BTL48_RS02545	COG1846	Transcriptional regulator
BTL48_RS02610	COG1028	Short-chain dehydrogenase reductase Sdr
BTL48_RS02615	COG1024	Enoyl-CoA hydratase
BTL48_RS02620	COG1960	acyl-CoA dehydrogenase activity
BTL48_RS02650	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BTL48_RS02655	COG0352	thiamine-phosphate diphosphorylase activity
BTL48_RS02660	COG0351	phosphomethylpyrimidine kinase
BTL48_RS02670	COG1678	Uncharacterized ACR, COG1678
BTL48_RS02675	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BTL48_RS02700	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BTL48_RS02710	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BTL48_RS02715	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BTL48_RS02725	COG0557	exoribonuclease II activity
BTL48_RS02735	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BTL48_RS02740	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BTL48_RS02745	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BTL48_RS02755	COG0439	Biotin carboxylase
BTL48_RS02760	COG2264	protein methyltransferase activity
BTL48_RS02770	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BTL48_RS02795	COG1696	Membrane protein involved in D-alanine export
BTL48_RS02800	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BTL48_RS02840	COG1522	sequence-specific DNA binding
BTL48_RS02855	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BTL48_RS02920	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BTL48_RS02945	COG3028	Belongs to the UPF0307 family
BTL48_RS02950	COG0312	modulator of DNA gyrase
BTL48_RS02955	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BTL48_RS02960	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BTL48_RS02965	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
BTL48_RS02975	COG0316	Belongs to the HesB IscA family
BTL48_RS02985	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
BTL48_RS02995	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BTL48_RS03000	COG1881	PFAM PEBP family protein
BTL48_RS03005	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BTL48_RS03010	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BTL48_RS03025	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BTL48_RS03025	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BTL48_RS03040	COG2718	Belongs to the UPF0229 family
BTL48_RS03045	COG2719	SpoVR family
BTL48_RS03110	COG0165	Argininosuccinate lyase
BTL48_RS03115	COG0589	response to stress
BTL48_RS03125	COG2816	NAD+ diphosphatase activity
BTL48_RS03130	COG4993	Dehydrogenase
BTL48_RS03155	COG3181	Tripartite tricarboxylate transporter family receptor
BTL48_RS03160	COG2979	Protein of unknown function (DUF533)
BTL48_RS03165	COG4206	TonB-dependent receptor
BTL48_RS03180	COG0741	lytic transglycosylase activity
BTL48_RS03180	COG1388	LysM domain
BTL48_RS03185	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BTL48_RS03190	COG2226	methyltransferase
BTL48_RS03195	COG0328	RNA-DNA hybrid ribonuclease activity
BTL48_RS03220	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BTL48_RS03240	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BTL48_RS03245	COG1129	ABC transporter
BTL48_RS03245	COG0842	Transport permease protein
BTL48_RS03250	COG0842	Transport permease protein
BTL48_RS03270	COG0463	Glycosyl transferase, family 2
BTL48_RS03275	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
BTL48_RS03290	COG1073	alpha beta
BTL48_RS03300	COG0697	spore germination
BTL48_RS03305	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BTL48_RS03330	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BTL48_RS03360	COG0823	Involved in the tonB-independent uptake of proteins
BTL48_RS03370	COG0848	biopolymer transport protein
BTL48_RS03375	COG0811	peptide transport
BTL48_RS03380	COG0824	Thioesterase
BTL48_RS03385	COG0442	prolyl-tRNA aminoacylation
BTL48_RS03430	COG2084	Dehydrogenase
BTL48_RS03475	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BTL48_RS03480	COG4654	Cytochrome c, class I
BTL48_RS03485	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BTL48_RS03550	COG1473	amidohydrolase
BTL48_RS03555	COG0418	dihydroorotase activity
BTL48_RS03560	COG0488	(ABC) transporter
BTL48_RS03570	COG2001	Belongs to the MraZ family
BTL48_RS03575	COG0275	rRNA processing
BTL48_RS03580	COG3116	cell division
BTL48_RS03590	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BTL48_RS03595	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BTL48_RS03600	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BTL48_RS03610	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BTL48_RS03615	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BTL48_RS03620	COG1181	Belongs to the D-alanine--D-alanine ligase family
BTL48_RS03625	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BTL48_RS03640	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
BTL48_RS03655	COG0739	heme binding
BTL48_RS03660	COG0653	protein targeting
BTL48_RS03685	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
BTL48_RS03690	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BTL48_RS03710	COG0828	Belongs to the bacterial ribosomal protein bS21 family
BTL48_RS03750	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
BTL48_RS03765	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
BTL48_RS03790	COG0583	DNA-binding transcription factor activity
BTL48_RS03800	COG3181	Tripartite tricarboxylate transporter family receptor
BTL48_RS03805	COG2084	Dehydrogenase
BTL48_RS03815	COG1597	lipid kinase activity
BTL48_RS03815	COG1803	Methylglyoxal synthase
BTL48_RS03825	COG0671	phosphoesterase, PA-phosphatase related
BTL48_RS03845	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
BTL48_RS03850	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BTL48_RS03855	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BTL48_RS03860	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BTL48_RS03865	COG0649	NAD binding
BTL48_RS03870	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
BTL48_RS03880	COG1034	ATP synthesis coupled electron transport
BTL48_RS03885	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
BTL48_RS03890	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BTL48_RS03900	COG0713	ATP synthesis coupled electron transport
BTL48_RS03915	COG1007	ATP synthesis coupled electron transport
BTL48_RS03925	COG0560	Phosphoserine phosphatase
BTL48_RS03930	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BTL48_RS03935	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
BTL48_RS03940	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BTL48_RS03955	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BTL48_RS03960	COG0450	alkyl hydroperoxide reductase
BTL48_RS03980	COG1214	PFAM Peptidase M22, glycoprotease
BTL48_RS03985	COG1573	uracil-dna glycosylase
BTL48_RS03990	COG0477	Major facilitator Superfamily
BTL48_RS03995	COG1196	nuclear chromosome segregation
BTL48_RS04005	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BTL48_RS04010	COG1126	abc transporter atp-binding protein
BTL48_RS04015	COG0765	amino acid transport
BTL48_RS04020	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BTL48_RS04025	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BTL48_RS04030	COG2917	probably involved in intracellular septation
BTL48_RS04035	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BTL48_RS04040	COG1122	ATPase activity
BTL48_RS04045	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
BTL48_RS04080	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BTL48_RS04105	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BTL48_RS04110	COG2878	Part of a membrane complex involved in electron transport
BTL48_RS04130	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
BTL48_RS04135	COG0251	oxidation-reduction process
BTL48_RS04145	COG3228	Belongs to the MtfA family
BTL48_RS04150	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BTL48_RS04160	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BTL48_RS04170	COG0159	tryptophan synthase activity
BTL48_RS04175	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
BTL48_RS04180	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
BTL48_RS04195	COG1530	ribonuclease E activity
BTL48_RS04200	COG0564	pseudouridine synthase activity
BTL48_RS04205	COG0546	phosphoglycolate phosphatase activity
BTL48_RS04210	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BTL48_RS04215	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
BTL48_RS04220	COG3023	N-Acetylmuramoyl-L-alanine amidase
BTL48_RS04230	COG0424	maF-like protein
BTL48_RS04240	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BTL48_RS04250	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BTL48_RS04260	COG1028	Short-chain dehydrogenase reductase Sdr
BTL48_RS04265	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BTL48_RS04270	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BTL48_RS04295	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BTL48_RS04315	COG0481	GTPase activity
BTL48_RS04320	COG0681	Belongs to the peptidase S26 family
BTL48_RS04325	COG0571	ribonuclease III activity
BTL48_RS04330	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BTL48_RS04335	COG1381	Involved in DNA repair and RecF pathway recombination
BTL48_RS04355	COG0670	Belongs to the BI1 family
BTL48_RS04370	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BTL48_RS04395	COG0583	DNA-binding transcription factor activity
BTL48_RS04415	COG0791	NLP P60 protein
BTL48_RS04420	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BTL48_RS04425	COG3193	protein, possibly involved in utilization of glycolate and propanediol
BTL48_RS04435	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BTL48_RS04455	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
BTL48_RS04490	COG1446	asparaginase
BTL48_RS04495	COG4172	Belongs to the ABC transporter superfamily
BTL48_RS04500	COG0747	negative chemotaxis
BTL48_RS04505	COG0601	transmembrane transport
BTL48_RS04530	COG0504	CTP synthase activity
BTL48_RS04540	COG0148	phosphopyruvate hydratase activity
BTL48_RS04555	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BTL48_RS04565	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BTL48_RS04570	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BTL48_RS04615	COG1981	membrane
BTL48_RS04635	COG0039	L-malate dehydrogenase activity
BTL48_RS04640	COG2188	Transcriptional regulator
BTL48_RS04645	COG2009	succinate dehydrogenase
BTL48_RS04650	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
BTL48_RS04655	COG1053	succinate dehydrogenase
BTL48_RS04660	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BTL48_RS04665	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
BTL48_RS04670	COG0372	Belongs to the citrate synthase family
BTL48_RS04685	COG0583	DNA-binding transcription factor activity
BTL48_RS04690	COG3842	ATPase activity
BTL48_RS04710	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BTL48_RS04720	COG3128	pkhd-type hydroxylase
BTL48_RS04725	COG4774	siderophore transport
BTL48_RS04735	COG0281	malic enzyme
BTL48_RS04735	COG0280	phosphate acetyltransferase
BTL48_RS04745	COG1297	OPT oligopeptide transporter protein
BTL48_RS04750	COG0567	Dehydrogenase, E1 component
BTL48_RS04755	COG0508	dehydrogenase complex catalyzes the overall conversion of
BTL48_RS04760	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BTL48_RS04765	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
BTL48_RS04770	COG1595	DNA-templated transcription, initiation
BTL48_RS04780	COG4774	siderophore transport
BTL48_RS04805	COG2183	response to ionizing radiation
BTL48_RS04810	COG1199	ATP-dependent helicase activity
BTL48_RS04820	COG0564	pseudouridine synthase activity
BTL48_RS04830	COG3243	poly(R)-hydroxyalkanoic acid synthase
BTL48_RS04835	COG1028	Short-chain dehydrogenase reductase Sdr
BTL48_RS04840	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
BTL48_RS04855	COG0672	)-iron permease
BTL48_RS04870	COG2823	Periplasmic or secreted lipoprotein
BTL48_RS04890	COG3237	CsbD-like
BTL48_RS04895	COG3038	cytochrome b561
BTL48_RS04910	COG1132	(ABC) transporter
BTL48_RS04925	COG2833	Protein of unknown function (DUF455)
BTL48_RS04930	COG2951	lytic endotransglycosylase activity
BTL48_RS04955	COG0586	Pfam SNARE associated Golgi protein
BTL48_RS05005	COG0165	Argininosuccinate lyase
BTL48_RS05025	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BTL48_RS05040	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BTL48_RS05045	COG0077	Prephenate dehydratase
BTL48_RS05045	COG1605	Chorismate mutase
BTL48_RS05050	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BTL48_RS05060	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BTL48_RS05065	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BTL48_RS05085	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
BTL48_RS05090	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
BTL48_RS05095	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BTL48_RS05100	COG0587	DNA-directed DNA polymerase activity
BTL48_RS05110	COG2951	lytic endotransglycosylase activity
BTL48_RS05115	COG0123	including yeast histone deacetylase and acetoin utilization protein
BTL48_RS05130	COG2985	domain, Protein
BTL48_RS05135	COG1960	acyl-CoA dehydrogenase activity
BTL48_RS05140	COG0450	alkyl hydroperoxide reductase
BTL48_RS05145	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
BTL48_RS05150	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
BTL48_RS05155	COG4208	sulfate ABC transporter
BTL48_RS05160	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
BTL48_RS05165	COG0175	sulfate reduction
BTL48_RS05190	COG0335	large ribosomal subunit rRNA binding
BTL48_RS05210	COG3622	Belongs to the hyi family
BTL48_RS05215	COG1162	GTPase activity
BTL48_RS05220	COG0501	Belongs to the peptidase M48B family
BTL48_RS05225	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
BTL48_RS05230	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
BTL48_RS05235	COG3327	negative regulation of DNA-templated transcription, initiation
BTL48_RS05240	COG3396	Phenylacetate-CoA oxygenase
BTL48_RS05245	COG3460	Phenylacetate-CoA oxygenase
BTL48_RS05250	COG3396	Phenylacetate-CoA oxygenase
BTL48_RS05255	COG2151	metal-sulfur cluster biosynthetic enzyme
BTL48_RS05260	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BTL48_RS05265	COG1012	belongs to the aldehyde dehydrogenase family
BTL48_RS05270	COG1024	Enoyl-CoA hydratase
BTL48_RS05275	COG2050	protein possibly involved in aromatic compounds catabolism
BTL48_RS05310	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BTL48_RS05310	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BTL48_RS05320	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BTL48_RS05325	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
BTL48_RS05330	COG2346	COG2346, Truncated hemoglobins
BTL48_RS05335	COG3642	lipopolysaccharide core region biosynthetic process
BTL48_RS05345	COG3842	ATPase activity
BTL48_RS05350	COG1176	ABC-type spermidine putrescine transport system, permease component I
BTL48_RS05355	COG1177	transmembrane transport
BTL48_RS05375	COG1322	Protein conserved in bacteria
BTL48_RS05385	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
BTL48_RS05390	COG0704	Plays a role in the regulation of phosphate uptake
BTL48_RS05395	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
BTL48_RS05400	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
BTL48_RS05400	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BTL48_RS05405	COG1643	Atp-dependent helicase
BTL48_RS05420	COG0438	transferase activity, transferring glycosyl groups
BTL48_RS05425	COG0726	polysaccharide deacetylase
BTL48_RS05430	COG0463	Glycosyl transferase, family 2
BTL48_RS05465	COG1132	(ABC) transporter
BTL48_RS05485	COG0501	Belongs to the peptidase M48B family
BTL48_RS05535	COG1722	exodeoxyribonuclease VII activity
BTL48_RS05540	COG0142	geranyltranstransferase activity
BTL48_RS05545	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BTL48_RS05550	COG1469	GTP cyclohydrolase I activity
BTL48_RS05555	COG0360	Binds together with S18 to 16S ribosomal RNA
BTL48_RS05560	COG2965	DNA replication, synthesis of RNA primer
BTL48_RS05565	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BTL48_RS05570	COG0359	binds to the 23S rRNA
BTL48_RS05580	COG0305	Participates in initiation and elongation during chromosome replication
BTL48_RS05600	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
BTL48_RS05605	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
BTL48_RS05610	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BTL48_RS05615	COG3737	Protein of unknown function (DUF498/DUF598)
BTL48_RS05620	COG0436	Aminotransferase
BTL48_RS05645	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
BTL48_RS05650	COG0308	aminopeptidase N
BTL48_RS05665	COG0312	modulator of DNA gyrase
BTL48_RS05670	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BTL48_RS05695	COG0277	FAD linked oxidase domain protein
BTL48_RS05700	COG0277	FAD linked oxidase domain protein
BTL48_RS05705	COG0247	lactate metabolic process
BTL48_RS05745	COG0583	DNA-binding transcription factor activity
BTL48_RS05750	COG0482	sulfurtransferase activity
BTL48_RS05755	COG0730	response to heat
BTL48_RS05760	COG0625	glutathione transferase activity
BTL48_RS05765	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BTL48_RS05770	COG3909	cytochrome
BTL48_RS05805	COG3706	GGDEF domain
BTL48_RS05820	COG2826	transposase and inactivated derivatives, IS30 family
BTL48_RS05840	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
BTL48_RS05865	COG0069	glutamate synthase activity
BTL48_RS05870	COG2391	methyltransferase activity
BTL48_RS05875	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
BTL48_RS05880	COG0679	Auxin Efflux Carrier
BTL48_RS05885	COG2153	protein acetylation
BTL48_RS05905	COG0557	exoribonuclease II activity
BTL48_RS05910	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BTL48_RS05915	COG2873	o-acetylhomoserine
BTL48_RS05920	COG0776	regulation of translation
BTL48_RS05950	COG0642	Histidine kinase
BTL48_RS05955	COG3158	transport of potassium into the cell
BTL48_RS05980	COG0137	argininosuccinate synthase activity
BTL48_RS05985	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BTL48_RS05990	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BTL48_RS06000	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BTL48_RS06015	COG2186	Transcriptional regulator
BTL48_RS06050	COG3836	Belongs to the HpcH HpaI aldolase family
BTL48_RS06055	COG0268	Binds directly to 16S ribosomal RNA
BTL48_RS06105	COG0728	peptidoglycan biosynthetic process
BTL48_RS06115	COG0563	adenylate kinase activity
BTL48_RS06120	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
BTL48_RS06125	COG2835	tetraacyldisaccharide 4'-kinase activity
BTL48_RS06130	COG1663	tetraacyldisaccharide 4'-kinase activity
BTL48_RS06135	COG0848	biopolymer transport protein
BTL48_RS06140	COG0811	peptide transport
BTL48_RS06145	COG1570	exodeoxyribonuclease VII activity
BTL48_RS06150	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BTL48_RS06160	COG0038	chloride channel
BTL48_RS06165	COG0183	Belongs to the thiolase family
BTL48_RS06175	COG1278	Cold shock
BTL48_RS06180	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
BTL48_RS06190	COG4953	penicillin-binding protein 1C
BTL48_RS06205	COG3008	intermembrane lipid transfer
BTL48_RS06215	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
BTL48_RS06215	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
BTL48_RS06215	COG0506	proline dehydrogenase activity
BTL48_RS06250	COG0004	ammonium transporteR
BTL48_RS06255	COG0347	Belongs to the P(II) protein family
BTL48_RS06305	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BTL48_RS06310	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BTL48_RS06315	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BTL48_RS06320	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BTL48_RS06320	COG0072	phenylalanine-tRNA ligase activity
BTL48_RS06325	COG0776	regulation of translation
BTL48_RS06355	COG1802	Transcriptional regulator
BTL48_RS06360	COG3181	Tripartite tricarboxylate transporter family receptor
BTL48_RS06380	COG1278	Cold shock
BTL48_RS06390	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BTL48_RS06410	COG1522	sequence-specific DNA binding
BTL48_RS06460	COG5265	(ABC) transporter
BTL48_RS06480	COG0656	L-ascorbic acid biosynthetic process
BTL48_RS06485	COG0667	Aldo Keto reductase
BTL48_RS06500	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BTL48_RS06545	COG1610	YqeY-like protein
BTL48_RS06560	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BTL48_RS06565	COG3246	L-lysine catabolic process to acetate
BTL48_RS06585	COG0318	PFAM AMP-dependent synthetase and ligase
BTL48_RS06600	COG0183	Belongs to the thiolase family
BTL48_RS06605	COG1024	Enoyl-CoA hydratase
BTL48_RS06605	COG1250	3-hydroxyacyl-CoA dehydrogenase
BTL48_RS06615	COG1250	3-hydroxyacyl-CoA dehydrogenase
BTL48_RS06615	COG1024	Enoyl-CoA hydratase
BTL48_RS06620	COG0183	Belongs to the thiolase family
BTL48_RS06625	COG1960	acyl-CoA dehydrogenase activity
BTL48_RS06635	COG1045	serine acetyltransferase
BTL48_RS06645	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BTL48_RS06650	COG0483	inositol monophosphate 1-phosphatase activity
BTL48_RS06655	COG1012	belongs to the aldehyde dehydrogenase family
BTL48_RS06660	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
BTL48_RS06675	COG0210	DNA helicase
BTL48_RS06680	COG0598	Magnesium transport protein CorA
BTL48_RS06690	COG0747	negative chemotaxis
BTL48_RS06695	COG0601	transmembrane transport
BTL48_RS06700	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BTL48_RS06705	COG4172	Belongs to the ABC transporter superfamily
BTL48_RS06725	COG1346	cytolysis
BTL48_RS06735	COG1028	Short-chain dehydrogenase reductase Sdr
BTL48_RS06740	COG0783	Belongs to the Dps family
BTL48_RS06760	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
BTL48_RS06770	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BTL48_RS06775	COG1845	cytochrome c oxidase, subunit III
BTL48_RS06780	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
BTL48_RS06825	COG1666	GTP binding
BTL48_RS06850	COG1028	Short-chain dehydrogenase reductase Sdr
BTL48_RS06855	COG5006	permease, DMT superfamily
BTL48_RS06880	COG2264	protein methyltransferase activity
BTL48_RS06915	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BTL48_RS06920	COG0746	molybdenum cofactor guanylyltransferase activity
BTL48_RS06925	COG0303	'Molybdopterin
BTL48_RS06930	COG0521	Mo-molybdopterin cofactor biosynthetic process
BTL48_RS06935	COG0314	molybdopterin synthase activity
BTL48_RS06945	COG0315	cyclic pyranopterin monophosphate synthase activity
BTL48_RS06950	COG0412	Dienelactone hydrolase
BTL48_RS06960	COG0678	peroxiredoxin activity
BTL48_RS06975	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BTL48_RS06985	COG0542	response to heat
BTL48_RS06995	COG1477	protein flavinylation
BTL48_RS07020	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BTL48_RS07025	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
BTL48_RS07025	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
BTL48_RS07030	COG1562	ergosterol biosynthetic process
BTL48_RS07035	COG1562	ergosterol biosynthetic process
BTL48_RS07040	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BTL48_RS07080	COG0254	rRNA binding
BTL48_RS07085	COG3483	tryptophan 2,3-dioxygenase activity
BTL48_RS07090	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
BTL48_RS07095	COG2003	Belongs to the UPF0758 family
BTL48_RS07105	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BTL48_RS07110	COG0625	glutathione transferase activity
BTL48_RS07130	COG0523	cobalamin synthesis protein
BTL48_RS07140	COG0583	DNA-binding transcription factor activity
BTL48_RS07150	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BTL48_RS07155	COG1187	pseudouridine synthase activity
BTL48_RS07160	COG0779	Required for maturation of 30S ribosomal subunits
BTL48_RS07165	COG2251	uridine kinase activity
BTL48_RS07165	COG0195	Participates in both transcription termination and antitermination
BTL48_RS07170	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BTL48_RS07175	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BTL48_RS07180	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BTL48_RS07185	COG1217	gtp-binding protein TYPA
BTL48_RS07200	COG1802	Transcriptional regulator
BTL48_RS07210	COG1024	Enoyl-CoA hydratase
BTL48_RS07215	COG0318	PFAM AMP-dependent synthetase and ligase
BTL48_RS07225	COG2032	superoxide dismutase activity
BTL48_RS07240	COG4120	Belongs to the binding-protein-dependent transport system permease family
BTL48_RS07245	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
BTL48_RS07250	COG0725	ABC transporter, periplasmic molybdate-binding protein
BTL48_RS07255	COG4149	molybdate abc transporter
BTL48_RS07285	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BTL48_RS07290	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BTL48_RS07295	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BTL48_RS07305	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
BTL48_RS07310	COG0736	holo-[acyl-carrier-protein] synthase activity
BTL48_RS07315	COG1472	Belongs to the glycosyl hydrolase 3 family
BTL48_RS07320	COG0322	excinuclease ABC activity
BTL48_RS07325	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BTL48_RS07335	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BTL48_RS07335	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BTL48_RS07340	COG2224	Isocitrate lyase
BTL48_RS07345	COG1846	Transcriptional regulator
BTL48_RS07350	COG1764	response to oxidative stress
BTL48_RS07355	COG1131	(ABC) transporter
BTL48_RS07365	COG0628	permease
BTL48_RS07380	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
BTL48_RS07390	COG2814	Major facilitator Superfamily
BTL48_RS07410	COG3015	lipoprotein NlpE involved in copper resistance
BTL48_RS07420	COG3530	Putative quorum-sensing-regulated virulence factor
BTL48_RS07435	COG0494	nUDIX hydrolase
BTL48_RS07445	COG0697	spore germination
BTL48_RS07450	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BTL48_RS07475	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BTL48_RS07480	COG1702	phosphate starvation-inducible protein PhoH
BTL48_RS07485	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BTL48_RS07490	COG4535	Mg2 and Co2 transporter CorC
BTL48_RS07495	COG0815	Transfers the fatty acyl group on membrane lipoproteins
BTL48_RS07500	COG0667	Aldo Keto reductase
BTL48_RS07520	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BTL48_RS07525	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BTL48_RS07530	COG1862	Preprotein translocase
BTL48_RS07535	COG0343	queuine tRNA-ribosyltransferase activity
BTL48_RS07540	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BTL48_RS07545	COG2027	D-alanyl-D-alanine carboxypeptidase
BTL48_RS07550	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BTL48_RS07555	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BTL48_RS07555	COG1648	precorrin-2 dehydrogenase activity
BTL48_RS07565	COG4575	ribosome binding
BTL48_RS07590	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
BTL48_RS07595	COG0741	lytic transglycosylase activity
BTL48_RS07600	COG0436	Aminotransferase
BTL48_RS07610	COG0281	malic enzyme
BTL48_RS07610	COG0280	phosphate acetyltransferase
BTL48_RS07625	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BTL48_RS07630	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BTL48_RS07635	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BTL48_RS07640	COG0126	phosphoglycerate kinase activity
BTL48_RS07655	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BTL48_RS07670	COG0625	glutathione transferase activity
BTL48_RS07690	COG0789	Transcriptional regulator
BTL48_RS07705	COG0306	phosphate transporter
BTL48_RS07710	COG0521	Mo-molybdopterin cofactor biosynthetic process
BTL48_RS07720	COG0739	heme binding
BTL48_RS07730	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BTL48_RS07770	COG0456	acetyltransferase
BTL48_RS07775	COG1301	dicarboxylic acid transport
BTL48_RS07785	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
BTL48_RS07790	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BTL48_RS07795	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BTL48_RS07800	COG0009	L-threonylcarbamoyladenylate synthase
BTL48_RS07810	COG4771	TonB-dependent receptor
BTL48_RS07840	COG1960	acyl-CoA dehydrogenase activity
BTL48_RS07845	COG0028	Belongs to the TPP enzyme family
BTL48_RS07850	COG0583	DNA-binding transcription factor activity
BTL48_RS07855	COG4974	Belongs to the 'phage' integrase family
BTL48_RS07860	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BTL48_RS07865	COG1686	Belongs to the peptidase S11 family
BTL48_RS07895	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BTL48_RS07900	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BTL48_RS07905	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BTL48_RS07925	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BTL48_RS07930	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BTL48_RS07935	COG0505	Belongs to the CarA family
BTL48_RS07940	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BTL48_RS07950	COG1028	Short-chain dehydrogenase reductase Sdr
BTL48_RS07955	COG0406	alpha-ribazole phosphatase activity
BTL48_RS07985	COG2233	PERMEase
BTL48_RS07990	COG3620	sequence-specific DNA binding
BTL48_RS08005	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BTL48_RS08015	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
BTL48_RS08020	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BTL48_RS08030	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BTL48_RS08045	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BTL48_RS08065	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BTL48_RS08125	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BTL48_RS08160	COG0540	Belongs to the ATCase OTCase family
BTL48_RS08165	COG2974	May be involved in recombination
BTL48_RS08190	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BTL48_RS08195	COG2137	regulation of response to DNA damage stimulus
BTL48_RS08205	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BTL48_RS08225	COG0045	succinate-CoA ligase (ADP-forming) activity
BTL48_RS08230	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BTL48_RS08235	COG0861	Integral membrane protein TerC family
BTL48_RS08240	COG0861	Integral membrane protein TerC family
BTL48_RS08245	COG0181	hydroxymethylbilane synthase activity
BTL48_RS08285	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BTL48_RS08330	COG1450	Type ii and iii secretion system protein
BTL48_RS08375	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BTL48_RS08385	COG1295	ribonuclease BN
BTL48_RS08395	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
BTL48_RS08415	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BTL48_RS08420	COG0501	Belongs to the peptidase M48B family
BTL48_RS08425	COG2197	response regulator
BTL48_RS08450	COG0066	3-isopropylmalate dehydratase activity
BTL48_RS08465	COG0473	3-isopropylmalate dehydrogenase activity
BTL48_RS08470	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BTL48_RS08480	COG0101	tRNA pseudouridine synthase activity
BTL48_RS08485	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
BTL48_RS08490	COG0135	phosphoribosylanthranilate isomerase activity
BTL48_RS08510	COG2801	Transposase and inactivated derivatives
BTL48_RS08515	COG2801	Transposase and inactivated derivatives
BTL48_RS08550	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BTL48_RS08555	COG2197	response regulator
BTL48_RS08560	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BTL48_RS08565	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BTL48_RS08580	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BTL48_RS08585	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BTL48_RS08595	COG1764	response to oxidative stress
BTL48_RS08610	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BTL48_RS08615	COG0765	amino acid transport
BTL48_RS08620	COG0765	amino acid transport
BTL48_RS08625	COG1126	abc transporter atp-binding protein
BTL48_RS08630	COG0756	dUTP diphosphatase activity
BTL48_RS08660	COG1522	sequence-specific DNA binding
BTL48_RS08680	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BTL48_RS08685	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BTL48_RS08690	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BTL48_RS08695	COG0196	riboflavin kinase activity
BTL48_RS08705	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BTL48_RS08705	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BTL48_RS08735	COG0210	DNA helicase
BTL48_RS08740	COG4771	TonB-dependent receptor
BTL48_RS08745	COG0488	(ABC) transporter
BTL48_RS08750	COG2890	protein-(glutamine-N5) methyltransferase activity
BTL48_RS08755	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BTL48_RS08760	COG2171	N-acyltransferase activity
BTL48_RS08815	COG2801	Transposase and inactivated derivatives
BTL48_RS08860	COG2814	Major facilitator Superfamily
BTL48_RS08885	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BTL48_RS08890	COG2900	Belongs to the SlyX family
BTL48_RS08905	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BTL48_RS08925	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BTL48_RS08950	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BTL48_RS08955	COG0583	DNA-binding transcription factor activity
BTL48_RS08960	COG1028	Short-chain dehydrogenase reductase Sdr
BTL48_RS08970	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BTL48_RS08975	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BTL48_RS08985	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BTL48_RS08990	COG0508	dehydrogenase complex catalyzes the overall conversion of
BTL48_RS08995	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
BTL48_RS09005	COG4566	intracellular signal transduction
BTL48_RS09010	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BTL48_RS09030	COG1999	signal sequence binding
BTL48_RS09050	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BTL48_RS09055	COG0583	DNA-binding transcription factor activity
BTL48_RS09060	COG1187	pseudouridine synthase activity
BTL48_RS09065	COG3161	chorismate lyase activity
BTL48_RS09080	COG1280	lysine exporter protein (LysE YggA)
BTL48_RS09115	COG1129	ABC transporter
BTL48_RS09130	COG0583	DNA-binding transcription factor activity
BTL48_RS09160	COG1185	polyribonucleotide nucleotidyltransferase activity
BTL48_RS09165	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BTL48_RS09180	COG1183	phosphatidylcholine synthase activity
BTL48_RS09190	COG0440	acetolactate synthase activity
BTL48_RS09195	COG0028	Belongs to the TPP enzyme family
BTL48_RS09220	COG3022	response to hydroperoxide
BTL48_RS09230	COG1028	Short-chain dehydrogenase reductase Sdr
BTL48_RS09245	COG3486	L-lysine 6-monooxygenase (NADPH) activity
BTL48_RS09275	COG2814	Major facilitator Superfamily
BTL48_RS09305	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BTL48_RS09340	COG2733	membrane
BTL48_RS09360	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
BTL48_RS09380	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BTL48_RS09385	COG0842	Transport permease protein
BTL48_RS09385	COG1129	ABC transporter
BTL48_RS09390	COG0842	Transport permease protein
BTL48_RS09400	COG1028	Short-chain dehydrogenase reductase Sdr
BTL48_RS09410	COG2259	Doxx family
BTL48_RS09440	COG0415	Belongs to the DNA photolyase family
BTL48_RS09460	COG0386	Belongs to the glutathione peroxidase family
BTL48_RS09475	COG0095	Lipoate-protein ligase
BTL48_RS09485	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BTL48_RS09495	COG0010	Belongs to the arginase family
BTL48_RS09505	COG0765	amino acid transport
BTL48_RS09510	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BTL48_RS09525	COG0084	hydrolase, TatD family'
BTL48_RS09535	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BTL48_RS09540	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BTL48_RS09550	COG2175	clavaminate synthase activity
BTL48_RS09555	COG0583	DNA-binding transcription factor activity
BTL48_RS09580	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
BTL48_RS09590	COG2914	Belongs to the UPF0125 (RnfH) family
BTL48_RS09600	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BTL48_RS09640	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BTL48_RS09640	COG0519	Catalyzes the synthesis of GMP from XMP
BTL48_RS09650	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
BTL48_RS09660	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BTL48_RS09665	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BTL48_RS09670	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BTL48_RS09680	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BTL48_RS09685	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BTL48_RS09695	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BTL48_RS09700	COG0750	zinc metalloprotease
BTL48_RS09705	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
BTL48_RS09715	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BTL48_RS09720	COG0233	cytoplasmic translational termination
BTL48_RS09725	COG0528	UMP kinase activity
BTL48_RS09730	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BTL48_RS09735	COG0052	Belongs to the universal ribosomal protein uS2 family
BTL48_RS09740	COG0024	Methionine aminopeptidase
BTL48_RS09745	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
BTL48_RS09765	COG1286	toxin biosynthetic process
BTL48_RS09775	COG0285	dihydrofolate synthase activity
BTL48_RS09785	COG3181	Tripartite tricarboxylate transporter family receptor
BTL48_RS09790	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BTL48_RS09830	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BTL48_RS09840	COG1677	Flagellar hook-basal body complex protein FliE
BTL48_RS09850	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BTL48_RS09855	COG1317	bacterial-type flagellum organization
BTL48_RS09875	COG1580	Controls the rotational direction of flagella during chemotaxis
BTL48_RS09885	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BTL48_RS09910	COG0840	transmembrane signaling receptor activity
BTL48_RS09915	COG0840	transmembrane signaling receptor activity
BTL48_RS09940	COG1191	sigma factor activity
BTL48_RS09980	COG2203	Gaf domain
BTL48_RS09980	COG2199	diguanylate cyclase activity
BTL48_RS10015	COG1126	abc transporter atp-binding protein
BTL48_RS10020	COG0765	amino acid transport
BTL48_RS10025	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BTL48_RS10070	COG2200	EAL domain
BTL48_RS10090	COG1253	flavin adenine dinucleotide binding
BTL48_RS10095	COG4251	negative regulation of phosphorylation
BTL48_RS10095	COG3706	GGDEF domain
BTL48_RS10095	COG2203	Gaf domain
BTL48_RS10095	COG5001	Diguanylate cyclase
BTL48_RS10100	COG2197	response regulator
BTL48_RS10105	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BTL48_RS10105	COG2205	protein histidine kinase activity
BTL48_RS10130	COG0076	glutamate decarboxylase activity
BTL48_RS10135	COG2985	domain, Protein
BTL48_RS10140	COG3189	MarR family transcriptional regulator
BTL48_RS10150	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BTL48_RS10160	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BTL48_RS10160	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BTL48_RS10170	COG0028	Belongs to the TPP enzyme family
BTL48_RS10180	COG1012	belongs to the aldehyde dehydrogenase family
BTL48_RS10190	COG0688	phosphatidylethanolamine metabolic process
BTL48_RS10195	COG1304	FMN binding
BTL48_RS10200	COG1464	Belongs to the NlpA lipoprotein family
BTL48_RS10220	COG0697	spore germination
BTL48_RS10225	COG2133	pyrroloquinoline quinone binding
BTL48_RS10230	COG0625	glutathione transferase activity
BTL48_RS10245	COG1794	racemase activity, acting on amino acids and derivatives
BTL48_RS10265	COG0559	Belongs to the binding-protein-dependent transport system permease family
BTL48_RS10275	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BTL48_RS10290	COG1175	transmembrane transport
BTL48_RS10295	COG0395	ABC-type sugar transport system, permease component
BTL48_RS10300	COG3842	ATPase activity
BTL48_RS10325	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
BTL48_RS10340	COG0438	transferase activity, transferring glycosyl groups
BTL48_RS10365	COG0463	Glycosyl transferase, family 2
BTL48_RS10380	COG0783	Belongs to the Dps family
BTL48_RS10385	COG0583	DNA-binding transcription factor activity
BTL48_RS10390	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BTL48_RS10420	COG1840	ABC-type Fe3 transport system, periplasmic component
BTL48_RS10430	COG3842	ATPase activity
BTL48_RS10435	COG1741	Belongs to the pirin family
BTL48_RS10440	COG1741	Belongs to the pirin family
BTL48_RS10445	COG0583	DNA-binding transcription factor activity
BTL48_RS10460	COG0174	glutamine synthetase
BTL48_RS10465	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BTL48_RS10470	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BTL48_RS10480	COG0840	transmembrane signaling receptor activity
BTL48_RS10495	COG0583	DNA-binding transcription factor activity
BTL48_RS10500	COG1960	acyl-CoA dehydrogenase activity
BTL48_RS10505	COG2079	MmgE PrpD family protein
BTL48_RS10515	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
BTL48_RS10520	COG1561	YicC-like family, N-terminal region
BTL48_RS10530	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BTL48_RS10535	COG0791	NLP P60 protein
BTL48_RS10540	COG1028	Short-chain dehydrogenase reductase Sdr
BTL48_RS10545	COG0194	GDP metabolic process
BTL48_RS10550	COG1758	RNA polymerase activity
BTL48_RS10555	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BTL48_RS10560	COG1126	abc transporter atp-binding protein
BTL48_RS10565	COG0765	amino acid transport
BTL48_RS10570	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BTL48_RS10580	COG2831	hemolysin activation secretion protein
BTL48_RS10590	COG3188	usher protein
BTL48_RS10595	COG3121	Chaperone
BTL48_RS10640	COG4181	ATPase activity
BTL48_RS10650	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BTL48_RS10655	COG0584	glycerophosphoryl diester phosphodiesterase
BTL48_RS10660	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
BTL48_RS10670	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
BTL48_RS10670	COG0678	peroxiredoxin activity
BTL48_RS10680	COG2217	Heavy metal translocating P-type atpase
BTL48_RS10685	COG0789	Transcriptional regulator
BTL48_RS10690	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BTL48_RS10725	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BTL48_RS10735	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
BTL48_RS10760	COG0583	DNA-binding transcription factor activity
BTL48_RS10765	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BTL48_RS10770	COG2252	PERMEase
BTL48_RS10775	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BTL48_RS10780	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BTL48_RS10815	COG0488	(ABC) transporter
BTL48_RS10820	COG1619	proteins homologs of microcin C7 resistance protein MccF
BTL48_RS10825	COG0590	tRNA wobble adenosine to inosine editing
BTL48_RS10840	COG1320	monovalent cation:proton antiporter activity
BTL48_RS10845	COG2212	antiporter activity
BTL48_RS10850	COG1863	multisubunit Na H antiporter MnhE subunit
BTL48_RS10855	COG0651	ATP synthesis coupled electron transport
BTL48_RS10860	COG1006	Multisubunit Na H antiporter MnhC subunit
BTL48_RS10865	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BTL48_RS10865	COG2111	Na H antiporter
BTL48_RS10870	COG3181	Tripartite tricarboxylate transporter family receptor
BTL48_RS10895	COG0420	3'-5' exonuclease activity
BTL48_RS10930	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BTL48_RS10940	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
BTL48_RS10950	COG2130	NADP-dependent
BTL48_RS10955	COG1309	transcriptional regulator
BTL48_RS10965	COG1131	(ABC) transporter
BTL48_RS10970	COG0842	Transport permease protein
BTL48_RS10980	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BTL48_RS11015	COG0602	queuosine metabolic process
BTL48_RS11020	COG0720	synthase
BTL48_RS11055	COG0587	DNA-directed DNA polymerase activity
BTL48_RS11065	COG0390	transport system, permease component
BTL48_RS11070	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BTL48_RS11075	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
BTL48_RS11130	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BTL48_RS11155	COG5507	3-demethylubiquinone-9 3-methyltransferase
BTL48_RS11190	COG1396	sequence-specific DNA binding
BTL48_RS11215	COG0583	DNA-binding transcription factor activity
BTL48_RS11220	COG2814	Major facilitator Superfamily
BTL48_RS11245	COG2807	transmembrane transport
BTL48_RS11250	COG2207	Transcriptional regulator
BTL48_RS11255	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BTL48_RS11260	COG2814	Major facilitator Superfamily
BTL48_RS11275	COG1012	belongs to the aldehyde dehydrogenase family
BTL48_RS11310	COG0583	DNA-binding transcription factor activity
BTL48_RS11330	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BTL48_RS11355	COG0384	phenazine biosynthesis protein PhzF
BTL48_RS11360	COG1733	regulation of RNA biosynthetic process
BTL48_RS11395	COG3177	Filamentation induced by cAMP protein fic
BTL48_RS11405	COG0519	Catalyzes the synthesis of GMP from XMP
BTL48_RS11405	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BTL48_RS11420	COG1695	Transcriptional regulator
BTL48_RS11435	COG2072	flavoprotein involved in K transport
BTL48_RS11440	COG0601	transmembrane transport
BTL48_RS11460	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BTL48_RS11470	COG4608	Belongs to the ABC transporter superfamily
BTL48_RS11475	COG0747	negative chemotaxis
BTL48_RS11515	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BTL48_RS11515	COG0047	phosphoribosylformylglycinamidine synthase activity
BTL48_RS11520	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BTL48_RS11540	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BTL48_RS11540	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BTL48_RS11545	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BTL48_RS11555	COG0613	PHP domain protein
BTL48_RS11615	COG1012	belongs to the aldehyde dehydrogenase family
BTL48_RS11625	COG0583	DNA-binding transcription factor activity
BTL48_RS11645	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BTL48_RS11655	COG3181	Tripartite tricarboxylate transporter family receptor
BTL48_RS11665	COG3181	Tripartite tricarboxylate transporter family receptor
BTL48_RS11695	COG1595	DNA-templated transcription, initiation
BTL48_RS11700	COG3712	iron ion homeostasis
BTL48_RS11710	COG0084	hydrolase, TatD family'
BTL48_RS11715	COG1136	(ABC) transporter
BTL48_RS11730	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BTL48_RS11740	COG1028	Short-chain dehydrogenase reductase Sdr
BTL48_RS11745	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BTL48_RS11755	COG1803	Methylglyoxal synthase
BTL48_RS11775	COG2801	Transposase and inactivated derivatives
BTL48_RS11780	COG2801	Transposase and inactivated derivatives
BTL48_RS11805	COG2975	iron-sulfur cluster assembly
BTL48_RS11810	COG0633	Ferredoxin
BTL48_RS11815	COG0443	Heat shock 70 kDa protein
BTL48_RS11820	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
BTL48_RS11825	COG0316	Belongs to the HesB IscA family
BTL48_RS11830	COG0822	iron-sulfur transferase activity
BTL48_RS11835	COG1104	cysteine desulfurase activity
BTL48_RS11845	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BTL48_RS11850	COG0556	nucleotide-excision repair
BTL48_RS11865	COG0583	DNA-binding transcription factor activity
BTL48_RS11885	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BTL48_RS11925	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BTL48_RS11940	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BTL48_RS11950	COG0740	serine-type endopeptidase activity
BTL48_RS11955	COG0544	peptidyl-prolyl cis-trans isomerase activity
BTL48_RS12020	COG1530	ribonuclease E activity
BTL48_RS12050	COG1846	Transcriptional regulator
BTL48_RS12060	COG1566	PFAM secretion protein HlyD family protein
BTL48_RS12065	COG2814	Major facilitator Superfamily
BTL48_RS12070	COG0473	3-isopropylmalate dehydrogenase activity
BTL48_RS12090	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BTL48_RS12095	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BTL48_RS12100	COG0433	COG0433 Predicted ATPase
BTL48_RS12105	COG0217	transcriptional regulatory protein
BTL48_RS12110	COG0151	Belongs to the GarS family
BTL48_RS12120	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BTL48_RS12125	COG0799	negative regulation of ribosome biogenesis
BTL48_RS12130	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BTL48_RS12135	COG0424	maF-like protein
BTL48_RS12145	COG4191	Histidine kinase
BTL48_RS12150	COG2204	response regulator
BTL48_RS12175	COG0500	methyltransferase
BTL48_RS12190	COG0803	Belongs to the bacterial solute-binding protein 9 family
BTL48_RS12195	COG1121	(ABC) transporter
BTL48_RS12200	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BTL48_RS12205	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BTL48_RS12235	COG4993	Dehydrogenase
BTL48_RS12245	COG4772	TonB-dependent receptor
BTL48_RS12250	COG2814	Major facilitator Superfamily
BTL48_RS12270	COG0037	tRNA processing
BTL48_RS12275	COG0825	malonyl-CoA metabolic process
BTL48_RS12285	COG0215	cysteine-tRNA ligase activity
BTL48_RS12295	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BTL48_RS12300	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BTL48_RS12305	COG1968	undecaprenyl-diphosphatase activity
BTL48_RS12310	COG1253	flavin adenine dinucleotide binding
BTL48_RS12315	COG0483	inositol monophosphate 1-phosphatase activity
BTL48_RS12335	COG0668	transmembrane transport
BTL48_RS12360	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BTL48_RS12370	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
BTL48_RS12385	COG1802	Transcriptional regulator
BTL48_RS12405	COG3360	Dodecin
BTL48_RS12425	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BTL48_RS12430	COG2850	peptidyl-arginine hydroxylation
BTL48_RS12440	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
BTL48_RS12445	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BTL48_RS12450	COG1994	Peptidase M50
BTL48_RS12455	COG0009	L-threonylcarbamoyladenylate synthase
BTL48_RS12460	COG2321	neutral zinc metallopeptidase
BTL48_RS12480	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BTL48_RS12490	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BTL48_RS12500	COG2271	Major facilitator Superfamily
BTL48_RS12575	COG2199	diguanylate cyclase activity
BTL48_RS12575	COG2200	EAL domain
BTL48_RS12575	COG2202	Pas domain
BTL48_RS12580	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
BTL48_RS12600	COG1960	acyl-CoA dehydrogenase activity
BTL48_RS12605	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BTL48_RS12610	COG2186	Transcriptional regulator
BTL48_RS12635	COG1595	DNA-templated transcription, initiation
BTL48_RS12670	COG1028	Short-chain dehydrogenase reductase Sdr
BTL48_RS12685	COG0179	Fumarylacetoacetate (FAA) hydrolase
BTL48_RS12705	COG4604	ABC transporter, ATP-binding protein
BTL48_RS12710	COG4605	iron ion homeostasis
BTL48_RS12715	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BTL48_RS12720	COG4607	ABC-type enterochelin transport system periplasmic component
BTL48_RS12725	COG0438	transferase activity, transferring glycosyl groups
BTL48_RS12735	COG0149	triose-phosphate isomerase activity
BTL48_RS12740	COG0604	alcohol dehydrogenase
BTL48_RS12740	COG3321	synthase
BTL48_RS12740	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BTL48_RS12740	COG4221	oxidoreductase activity
BTL48_RS12770	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BTL48_RS12770	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BTL48_RS12775	COG0668	transmembrane transport
BTL48_RS12780	COG0165	Argininosuccinate lyase
BTL48_RS12790	COG0789	Transcriptional regulator
BTL48_RS12800	COG0501	Belongs to the peptidase M48B family
BTL48_RS12805	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BTL48_RS12830	COG1024	Enoyl-CoA hydratase
BTL48_RS12835	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BTL48_RS12855	COG3468	outer membrane autotransporter barrel domain protein
BTL48_RS12895	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BTL48_RS12900	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BTL48_RS12905	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
BTL48_RS12910	COG1674	ftsk spoiiie
BTL48_RS12915	COG0492	ferredoxin-NADP+ reductase activity
BTL48_RS12920	COG1193	negative regulation of DNA recombination
BTL48_RS12935	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BTL48_RS12950	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
BTL48_RS12955	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
BTL48_RS12960	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
BTL48_RS12970	COG0745	RESPONSE REGULATOR receiver
BTL48_RS13005	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BTL48_RS13025	COG0612	Peptidase, M16
BTL48_RS13035	COG0443	Heat shock 70 kDa protein
BTL48_RS13045	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BTL48_RS13055	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
BTL48_RS13060	COG1420	regulation of RNA biosynthetic process
BTL48_RS13065	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BTL48_RS13070	COG0497	DNA recombination
BTL48_RS13100	COG0735	belongs to the Fur family
BTL48_RS13105	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BTL48_RS13150	COG2828	Protein conserved in bacteria
BTL48_RS13155	COG1280	lysine exporter protein (LysE YggA)
BTL48_RS13160	COG3181	Tripartite tricarboxylate transporter family receptor
BTL48_RS13175	COG1028	Short-chain dehydrogenase reductase Sdr
BTL48_RS13180	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
BTL48_RS13185	COG1802	Transcriptional regulator
BTL48_RS13190	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
BTL48_RS13195	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BTL48_RS13200	COG1335	isochorismatase
BTL48_RS13205	COG0523	cobalamin synthesis protein
BTL48_RS13235	COG0583	DNA-binding transcription factor activity
BTL48_RS13245	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
BTL48_RS13250	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
BTL48_RS13255	COG0167	dihydroorotate dehydrogenase activity
BTL48_RS13305	COG1414	Transcriptional regulator
BTL48_RS13325	COG0513	Belongs to the DEAD box helicase family
BTL48_RS13350	COG0429	hydrolase of the alpha beta-hydrolase fold
BTL48_RS13395	COG0006	proline dipeptidase activity
BTL48_RS13405	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BTL48_RS13430	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
BTL48_RS13435	COG0632	four-way junction helicase activity
BTL48_RS13450	COG2255	four-way junction helicase activity
BTL48_RS13455	COG0514	ATP-dependent DNA helicase (RecQ)
BTL48_RS13475	COG1294	oxidase, subunit
BTL48_RS13485	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BTL48_RS13490	COG0850	regulation of cytokinetic process
BTL48_RS13495	COG2894	cell division
BTL48_RS13500	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
BTL48_RS13525	COG0488	(ABC) transporter
BTL48_RS13540	COG4608	Belongs to the ABC transporter superfamily
BTL48_RS13545	COG0444	Belongs to the ABC transporter superfamily
BTL48_RS13550	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BTL48_RS13565	COG1215	transferase activity, transferring glycosyl groups
BTL48_RS13570	COG0583	DNA-binding transcription factor activity
BTL48_RS13575	COG1368	sulfuric ester hydrolase activity
BTL48_RS13590	COG1280	lysine exporter protein (LysE YggA)
BTL48_RS13600	COG1064	alcohol dehydrogenase
BTL48_RS13610	COG4566	intracellular signal transduction
BTL48_RS13620	COG1802	Transcriptional regulator
BTL48_RS13645	COG3181	Tripartite tricarboxylate transporter family receptor
BTL48_RS13650	COG0513	Belongs to the DEAD box helicase family
BTL48_RS13655	COG0668	transmembrane transport
BTL48_RS13670	COG1595	DNA-templated transcription, initiation
BTL48_RS13710	COG0583	DNA-binding transcription factor activity
BTL48_RS13715	COG0531	amino acid
BTL48_RS13720	COG1982	Orn Lys Arg decarboxylase major
BTL48_RS13745	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BTL48_RS13750	COG0459	protein refolding
BTL48_RS13760	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
BTL48_RS13765	COG1252	NADH dehydrogenase
BTL48_RS13770	COG0284	orotidine-5'-phosphate decarboxylase activity
BTL48_RS13780	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BTL48_RS13790	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BTL48_RS13795	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BTL48_RS13825	COG1595	DNA-templated transcription, initiation
BTL48_RS13835	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
BTL48_RS13840	COG3639	organic phosphonate transmembrane transporter activity
BTL48_RS13845	COG3639	organic phosphonate transmembrane transporter activity
BTL48_RS13860	COG0742	ribosomal rna small subunit methyltransferase
BTL48_RS13865	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BTL48_RS13870	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
BTL48_RS13875	COG3135	benzoate transporter
BTL48_RS13895	COG4774	siderophore transport
BTL48_RS13920	COG1024	Enoyl-CoA hydratase
BTL48_RS13925	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BTL48_RS13930	COG1960	acyl-CoA dehydrogenase activity
BTL48_RS13940	COG0318	PFAM AMP-dependent synthetase and ligase
BTL48_RS13945	COG3181	Tripartite tricarboxylate transporter family receptor
BTL48_RS13955	COG0583	DNA-binding transcription factor activity
BTL48_RS13980	COG0277	FAD linked oxidase domain protein
BTL48_RS14000	COG1802	Transcriptional regulator
BTL48_RS14010	COG2271	Major facilitator Superfamily
BTL48_RS14020	COG0583	DNA-binding transcription factor activity
BTL48_RS14045	COG0012	GTP binding
BTL48_RS14055	COG0193	aminoacyl-tRNA hydrolase activity
BTL48_RS14060	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
BTL48_RS14065	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BTL48_RS14075	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BTL48_RS14090	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BTL48_RS14115	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
BTL48_RS14125	COG1368	sulfuric ester hydrolase activity
BTL48_RS14130	COG2186	Transcriptional regulator
BTL48_RS14140	COG3181	Tripartite tricarboxylate transporter family receptor
BTL48_RS14155	COG0277	FAD linked oxidase domain protein
BTL48_RS14170	COG0166	Belongs to the GPI family
BTL48_RS14175	COG0438	transferase activity, transferring glycosyl groups
BTL48_RS14180	COG0438	transferase activity, transferring glycosyl groups
BTL48_RS14195	COG0438	transferase activity, transferring glycosyl groups
BTL48_RS14210	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
BTL48_RS14215	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BTL48_RS14230	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
BTL48_RS14240	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BTL48_RS14250	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BTL48_RS14255	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BTL48_RS14270	COG0747	negative chemotaxis
BTL48_RS14280	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BTL48_RS14285	COG4172	Belongs to the ABC transporter superfamily
BTL48_RS14305	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BTL48_RS14305	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BTL48_RS14310	COG0509	glycine decarboxylation via glycine cleavage system
BTL48_RS14315	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BTL48_RS14320	COG2081	HI0933 family
BTL48_RS14335	COG0456	acetyltransferase
BTL48_RS14340	COG0717	Belongs to the dCTP deaminase family
BTL48_RS14355	COG0489	protein tyrosine kinase activity
BTL48_RS14365	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BTL48_RS14365	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BTL48_RS14390	COG3539	Fimbrial protein
BTL48_RS14405	COG0745	RESPONSE REGULATOR receiver
BTL48_RS14430	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
BTL48_RS14445	COG2084	Dehydrogenase
BTL48_RS14450	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BTL48_RS14475	COG3842	ATPase activity
BTL48_RS14480	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
BTL48_RS14485	COG1960	acyl-CoA dehydrogenase activity
BTL48_RS14495	COG0583	DNA-binding transcription factor activity
BTL48_RS14505	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BTL48_RS14510	COG1024	Enoyl-CoA hydratase
BTL48_RS14525	COG0583	DNA-binding transcription factor activity
BTL48_RS14530	COG1408	metallophosphoesterase
BTL48_RS14535	COG0625	glutathione transferase activity
BTL48_RS14570	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BTL48_RS14570	COG0426	domain, Protein
BTL48_RS14575	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BTL48_RS14580	COG0583	DNA-binding transcription factor activity
BTL48_RS14590	COG1024	Enoyl-CoA hydratase
BTL48_RS14600	COG1960	acyl-CoA dehydrogenase activity
BTL48_RS14605	COG1028	Short-chain dehydrogenase reductase Sdr
BTL48_RS14610	COG1028	Short-chain dehydrogenase reductase Sdr
BTL48_RS14630	COG3181	Tripartite tricarboxylate transporter family receptor
BTL48_RS14635	COG1028	Short-chain dehydrogenase reductase Sdr
BTL48_RS14645	COG3181	Tripartite tricarboxylate transporter family receptor
BTL48_RS14685	COG0583	DNA-binding transcription factor activity
BTL48_RS14690	COG1960	acyl-CoA dehydrogenase activity
BTL48_RS14695	COG3181	Tripartite tricarboxylate transporter family receptor
BTL48_RS14700	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BTL48_RS14705	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BTL48_RS14730	COG0560	Phosphoserine phosphatase
BTL48_RS14735	COG0583	DNA-binding transcription factor activity
BTL48_RS14750	COG3842	ATPase activity
BTL48_RS14765	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BTL48_RS14785	COG0625	glutathione transferase activity
BTL48_RS14830	COG4336	lyase activity
BTL48_RS14840	COG0326	Molecular chaperone. Has ATPase activity
BTL48_RS14845	COG2233	PERMEase
BTL48_RS14885	COG2818	Glycosylase
BTL48_RS14890	COG0727	PFAM Uncharacterised protein family (UPF0153)
BTL48_RS14915	COG0402	S-adenosylhomocysteine deaminase activity
BTL48_RS14925	COG0156	8-amino-7-oxononanoate synthase activity
BTL48_RS14930	COG2877	3-deoxy-8-phosphooctulonate synthase activity
BTL48_RS14985	COG1464	Belongs to the NlpA lipoprotein family
BTL48_RS14990	COG2011	ABC-type metal ion transport system permease component
BTL48_RS14995	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BTL48_RS15000	COG1501	Belongs to the glycosyl hydrolase 31 family
BTL48_RS15005	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
BTL48_RS15005	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BTL48_RS15010	COG0483	inositol monophosphate 1-phosphatase activity
BTL48_RS15015	COG0318	PFAM AMP-dependent synthetase and ligase
BTL48_RS15020	COG1473	amidohydrolase
BTL48_RS15025	COG0583	DNA-binding transcription factor activity
BTL48_RS15030	COG2855	membrane
BTL48_RS15040	COG2239	Acts as a magnesium transporter
BTL48_RS15055	COG1522	sequence-specific DNA binding
BTL48_RS15095	COG0330	HflC and HflK could
BTL48_RS15100	COG0330	HflC and HflK could
BTL48_RS15105	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BTL48_RS15110	COG1923	regulation of RNA biosynthetic process
BTL48_RS15120	COG1160	GTP binding
BTL48_RS15125	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BTL48_RS15130	COG2976	Protein conserved in bacteria
BTL48_RS15135	COG0124	histidyl-tRNA synthetase
BTL48_RS15150	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BTL48_RS15155	COG0105	UTP biosynthetic process
BTL48_RS15160	COG0525	valine-tRNA ligase activity
BTL48_RS15170	COG0336	Belongs to the RNA methyltransferase TrmD family
BTL48_RS15175	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BTL48_RS15180	COG0228	four-way junction DNA binding
BTL48_RS15185	COG0425	Belongs to the sulfur carrier protein TusA family
BTL48_RS15190	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BTL48_RS15255	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BTL48_RS15260	COG0543	2 iron, 2 sulfur cluster binding
BTL48_RS15260	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BTL48_RS15265	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
BTL48_RS15270	COG2076	Multidrug Resistance protein
BTL48_RS15275	COG3217	Mosc domain protein beta barrel domain protein
BTL48_RS15275	COG0633	Ferredoxin
BTL48_RS15280	COG5285	phytanoyl-CoA dioxygenase
BTL48_RS15285	COG0662	Cupin 2, conserved barrel domain protein
BTL48_RS15295	COG0456	acetyltransferase
BTL48_RS15315	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BTL48_RS15345	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BTL48_RS15355	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
BTL48_RS15360	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BTL48_RS15365	COG1760	l-serine dehydratase
BTL48_RS15370	COG1283	sodium-dependent phosphate transmembrane transporter activity
BTL48_RS15375	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BTL48_RS15380	COG0412	Dienelactone hydrolase
BTL48_RS15385	COG0428	transporter
BTL48_RS15395	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BTL48_RS15400	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BTL48_RS15405	COG1845	cytochrome c oxidase, subunit III
BTL48_RS15410	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
BTL48_RS15420	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BTL48_RS15420	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BTL48_RS15445	COG1942	4-Oxalocrotonate Tautomerase
BTL48_RS15455	COG4176	ABC-type proline glycine betaine transport system permease component
BTL48_RS15475	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BTL48_RS15480	COG2814	Major facilitator Superfamily
BTL48_RS15485	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BTL48_RS15490	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BTL48_RS15515	COG1846	Transcriptional regulator
BTL48_RS15520	COG2814	Major facilitator Superfamily
BTL48_RS15525	COG0495	leucyl-tRNA aminoacylation
BTL48_RS15540	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BTL48_RS15560	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BTL48_RS15565	COG2274	protein secretion by the type I secretion system
BTL48_RS15610	COG0427	acetyl-CoA hydrolase
BTL48_RS15620	COG3264	Mechanosensitive ion channel
BTL48_RS15620	COG1511	domain protein
BTL48_RS15625	COG0730	response to heat
BTL48_RS15640	COG2176	DNA-directed DNA polymerase activity
BTL48_RS15660	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
BTL48_RS15665	COG3384	dioxygenase
BTL48_RS15680	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BTL48_RS15750	COG4964	Belongs to the GSP D family
BTL48_RS15795	COG1846	Transcriptional regulator
BTL48_RS15830	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
BTL48_RS15840	COG2070	2-Nitropropane dioxygenase
BTL48_RS15845	COG2070	2-Nitropropane dioxygenase
BTL48_RS15855	COG2610	gluconate transmembrane transporter activity
BTL48_RS15870	COG1408	metallophosphoesterase
BTL48_RS15875	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
BTL48_RS15875	COG0493	'glutamate synthase
BTL48_RS15880	COG2199	diguanylate cyclase activity
BTL48_RS15885	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
BTL48_RS15920	COG2159	amidohydrolase
BTL48_RS15930	COG0583	DNA-binding transcription factor activity
BTL48_RS15945	COG1024	Enoyl-CoA hydratase
BTL48_RS15950	COG2186	Transcriptional regulator
BTL48_RS15955	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BTL48_RS15965	COG0833	amino acid
BTL48_RS15975	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
BTL48_RS16010	COG5265	(ABC) transporter
BTL48_RS16050	COG1971	Probably functions as a manganese efflux pump
BTL48_RS16055	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BTL48_RS16065	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BTL48_RS16070	COG2814	Major facilitator Superfamily
BTL48_RS16095	COG4608	Belongs to the ABC transporter superfamily
BTL48_RS16115	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BTL48_RS16125	COG3383	formate dehydrogenase (NAD+) activity
BTL48_RS16140	COG0747	negative chemotaxis
BTL48_RS16150	COG0625	glutathione transferase activity
BTL48_RS16180	COG1595	DNA-templated transcription, initiation
BTL48_RS16190	COG4774	siderophore transport
BTL48_RS16205	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BTL48_RS16220	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
BTL48_RS16225	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
BTL48_RS16250	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BTL48_RS16255	COG1024	Enoyl-CoA hydratase
BTL48_RS16290	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BTL48_RS16295	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BTL48_RS16300	COG1116	anion transmembrane transporter activity
BTL48_RS16305	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BTL48_RS16310	COG3585	molybdate ion transport
BTL48_RS16370	COG0583	DNA-binding transcription factor activity
BTL48_RS16375	COG4948	Mandelate Racemase Muconate Lactonizing
BTL48_RS16380	COG3181	Tripartite tricarboxylate transporter family receptor
BTL48_RS16410	COG3181	Tripartite tricarboxylate transporter family receptor
BTL48_RS16445	COG4177	L-phenylalanine transmembrane transporter activity
BTL48_RS16470	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BTL48_RS16485	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BTL48_RS16490	COG1538	Outer membrane efflux protein
BTL48_RS16495	COG0577	efflux transmembrane transporter activity
BTL48_RS16495	COG1136	(ABC) transporter
BTL48_RS16500	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BTL48_RS16515	COG0259	pyridoxamine-phosphate oxidase activity
BTL48_RS16520	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BTL48_RS16525	COG0579	oxidoreductase
BTL48_RS16535	COG0405	Gamma-glutamyltransferase
BTL48_RS16545	COG3181	Tripartite tricarboxylate transporter family receptor
BTL48_RS16555	COG0114	fumarate hydratase activity
BTL48_RS16560	COG0802	atpase or kinase
BTL48_RS16565	COG0860	N-Acetylmuramoyl-L-alanine amidase
BTL48_RS16570	COG0586	Pfam SNARE associated Golgi protein
BTL48_RS16575	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BTL48_RS16580	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BTL48_RS16585	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BTL48_RS16600	COG0617	tRNA 3'-terminal CCA addition
BTL48_RS16635	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
BTL48_RS16645	COG1024	Enoyl-CoA hydratase
BTL48_RS16655	COG2188	Transcriptional regulator
BTL48_RS16660	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BTL48_RS16675	COG0752	glycyl-tRNA synthetase alpha subunit
BTL48_RS16680	COG0751	glycine-tRNA ligase activity
BTL48_RS16685	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
BTL48_RS16690	COG0204	Acyl-transferase
BTL48_RS16720	COG0242	peptide deformylase activity
BTL48_RS16730	COG0700	Nucleoside recognition
BTL48_RS16735	COG0469	pyruvate kinase activity
BTL48_RS16740	COG1929	Belongs to the glycerate kinase type-1 family
BTL48_RS16750	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BTL48_RS16755	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BTL48_RS16760	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
BTL48_RS16770	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
BTL48_RS16780	COG2154	pterin-4-alpha-carbinolamine dehydratase
BTL48_RS16785	COG2885	chlorophyll binding
BTL48_RS16795	COG0667	Aldo Keto reductase
BTL48_RS16805	COG3181	Tripartite tricarboxylate transporter family receptor
BTL48_RS16825	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BTL48_RS16830	COG0288	reversible hydration of carbon dioxide
BTL48_RS16850	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BTL48_RS16860	COG4829	muconolactone delta-isomerase
BTL48_RS16865	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
BTL48_RS16875	COG1414	Transcriptional regulator
BTL48_RS16880	COG1028	Short-chain dehydrogenase reductase Sdr
BTL48_RS16885	COG2031	fatty acid transporter
BTL48_RS16890	COG1250	3-hydroxyacyl-CoA dehydrogenase
BTL48_RS16900	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
BTL48_RS16905	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
BTL48_RS16920	COG0129	dihydroxy-acid dehydratase activity
BTL48_RS16925	COG1609	Transcriptional regulator
BTL48_RS16945	COG4106	trans-aconitate 2-methyltransferase activity
BTL48_RS16965	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BTL48_RS17000	COG0163	prenyltransferase activity
BTL48_RS17005	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BTL48_RS17010	COG2890	protein-(glutamine-N5) methyltransferase activity
BTL48_RS17015	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BTL48_RS17020	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
BTL48_RS17035	COG3712	iron ion homeostasis
BTL48_RS17065	COG0659	secondary active sulfate transmembrane transporter activity
BTL48_RS17085	COG1028	Short-chain dehydrogenase reductase Sdr
BTL48_RS17100	COG4774	siderophore transport
BTL48_RS17110	COG1595	DNA-templated transcription, initiation
BTL48_RS17125	COG0142	geranyltranstransferase activity
BTL48_RS17130	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BTL48_RS17135	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BTL48_RS17140	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BTL48_RS17145	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BTL48_RS17165	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BTL48_RS17165	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BTL48_RS17170	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
BTL48_RS17185	COG0583	DNA-binding transcription factor activity
BTL48_RS17190	COG0861	Integral membrane protein TerC family
BTL48_RS17205	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BTL48_RS17210	COG0793	Belongs to the peptidase S41A family
BTL48_RS17215	COG4942	peptidase
BTL48_RS17220	COG0588	phosphoglycerate mutase activity
BTL48_RS17230	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
BTL48_RS17235	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
BTL48_RS17240	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BTL48_RS17245	COG3181	Tripartite tricarboxylate transporter family receptor
BTL48_RS17260	COG2226	methyltransferase
BTL48_RS17265	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
BTL48_RS17270	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BTL48_RS17280	COG2204	response regulator
BTL48_RS17285	COG5000	phosphorelay sensor kinase activity
BTL48_RS17295	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BTL48_RS17295	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BTL48_RS17335	COG2188	Transcriptional regulator
BTL48_RS17350	COG0583	DNA-binding transcription factor activity
BTL48_RS17355	COG1012	belongs to the aldehyde dehydrogenase family
BTL48_RS17375	COG0546	phosphoglycolate phosphatase activity
BTL48_RS17390	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BTL48_RS17395	COG0242	peptide deformylase activity
BTL48_RS17405	COG1522	sequence-specific DNA binding
BTL48_RS17410	COG2879	small protein
BTL48_RS17415	COG1966	Carbon starvation protein
BTL48_RS17445	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BTL48_RS17450	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BTL48_RS17455	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BTL48_RS17460	COG3181	Tripartite tricarboxylate transporter family receptor
BTL48_RS17525	COG1172	Belongs to the binding-protein-dependent transport system permease family
BTL48_RS17560	COG0640	Transcriptional regulator
BTL48_RS17600	COG0735	belongs to the Fur family
BTL48_RS17605	COG2207	Transcriptional regulator
BTL48_RS17610	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BTL48_RS17615	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BTL48_RS17620	COG0513	Belongs to the DEAD box helicase family
BTL48_RS17650	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BTL48_RS17665	COG1305	Transglutaminase-like
BTL48_RS17705	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BTL48_RS17710	COG1950	PFAM Membrane protein of
BTL48_RS17735	COG0024	Methionine aminopeptidase
BTL48_RS17740	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BTL48_RS17750	COG1560	Kdo2-lipid A biosynthetic process
BTL48_RS17755	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BTL48_RS17765	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
BTL48_RS17800	COG0735	belongs to the Fur family
BTL48_RS17805	COG0523	cobalamin synthesis protein
BTL48_RS17820	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
BTL48_RS17830	COG2096	Adenosyltransferase
BTL48_RS17835	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BTL48_RS17840	COG0321	lipoyl(octanoyl) transferase activity
BTL48_RS17850	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BTL48_RS17855	COG1686	Belongs to the peptidase S11 family
BTL48_RS17880	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BTL48_RS17890	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
BTL48_RS17900	COG0859	PFAM glycosyl transferase family 9
BTL48_RS17935	COG0477	Major facilitator Superfamily
BTL48_RS17950	COG3568	Endonuclease Exonuclease Phosphatase
BTL48_RS17955	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BTL48_RS17985	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BTL48_RS17990	COG1956	GAF domain-containing protein
BTL48_RS17995	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BTL48_RS18010	COG2186	Transcriptional regulator
BTL48_RS18015	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
BTL48_RS18030	COG1840	ABC-type Fe3 transport system, periplasmic component
BTL48_RS18070	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BTL48_RS18075	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BTL48_RS18080	COG1086	Polysaccharide biosynthesis protein
BTL48_RS18115	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
BTL48_RS18125	COG1028	Short-chain dehydrogenase reductase Sdr
BTL48_RS18130	COG1012	belongs to the aldehyde dehydrogenase family
BTL48_RS18155	COG1522	sequence-specific DNA binding
BTL48_RS18160	COG3781	membrane
BTL48_RS18200	COG2200	EAL domain
BTL48_RS18210	COG0592	DNA-directed DNA polymerase activity
BTL48_RS18215	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BTL48_RS18220	COG0230	Belongs to the bacterial ribosomal protein bL34 family
BTL48_RS18225	COG0594	ribonuclease P activity
BTL48_RS18230	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
BTL48_RS18235	COG0706	membrane insertase activity
BTL48_RS18240	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
BTL48_RS18245	COG1473	amidohydrolase
BTL48_RS18250	COG4608	Belongs to the ABC transporter superfamily
BTL48_RS18255	COG0444	Belongs to the ABC transporter superfamily
BTL48_RS18260	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BTL48_RS18265	COG0601	transmembrane transport
BTL48_RS18275	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BTL48_RS18280	COG1505	serine-type exopeptidase activity
BTL48_RS18290	COG0281	malic enzyme
BTL48_RS18290	COG0280	phosphate acetyltransferase
BTL48_RS18320	COG0436	Aminotransferase
BTL48_RS18325	COG1278	Cold shock