locus-tag	class	description
BTL49_RS00005	COG0445	tRNA wobble uridine modification
BTL49_RS00010	COG0357	Ribosomal RNA small subunit methyltransferase G
BTL49_RS00015	COG1192	Involved in chromosome partitioning
BTL49_RS00020	COG1475	DNA binding
BTL49_RS00025	COG0252	asparaginase activity
BTL49_RS00045	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BTL49_RS00055	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BTL49_RS00065	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BTL49_RS00070	COG0081	regulation of translation
BTL49_RS00075	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BTL49_RS00080	COG0222	ribosome binding
BTL49_RS00085	COG0085	RNA polymerase activity
BTL49_RS00090	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BTL49_RS00125	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BTL49_RS00130	COG0049	tRNA binding
BTL49_RS00135	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BTL49_RS00140	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BTL49_RS00145	COG0051	transcription antitermination factor activity, RNA binding
BTL49_RS00150	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BTL49_RS00155	COG0088	Forms part of the polypeptide exit tunnel
BTL49_RS00160	COG0089	rRNA binding
BTL49_RS00165	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BTL49_RS00170	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BTL49_RS00175	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BTL49_RS00180	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BTL49_RS00185	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BTL49_RS00190	COG0255	Belongs to the universal ribosomal protein uL29 family
BTL49_RS00195	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BTL49_RS00205	COG4177	L-phenylalanine transmembrane transporter activity
BTL49_RS00215	COG1129	ABC transporter
BTL49_RS00220	COG0411	ABC transporter
BTL49_RS00250	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BTL49_RS00255	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BTL49_RS00260	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BTL49_RS00265	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BTL49_RS00270	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BTL49_RS00275	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BTL49_RS00280	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BTL49_RS00285	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BTL49_RS00290	COG1841	ribosomal large subunit assembly
BTL49_RS00295	COG0200	Binds to the 23S rRNA
BTL49_RS00300	COG0201	protein transport
BTL49_RS00305	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BTL49_RS00310	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BTL49_RS00315	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BTL49_RS00320	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BTL49_RS00325	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BTL49_RS00330	COG0202	RNA polymerase activity
BTL49_RS00335	COG0203	ribosomal protein L17
BTL49_RS00340	COG0537	adenosine 5'-monophosphoramidase activity
BTL49_RS00345	COG1324	tolerance protein
BTL49_RS00350	COG4232	protein-disulfide reductase activity
BTL49_RS00365	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BTL49_RS00375	COG1333	cytochrome c biogenesis protein
BTL49_RS00380	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BTL49_RS00395	COG1965	Belongs to the frataxin family
BTL49_RS00405	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BTL49_RS00410	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BTL49_RS00415	COG0232	Belongs to the dGTPase family. Type 2 subfamily
BTL49_RS00435	COG2814	Major facilitator Superfamily
BTL49_RS00480	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BTL49_RS00485	COG2922	Belongs to the Smg family
BTL49_RS00490	COG1629	transport
BTL49_RS00500	COG2358	TRAP transporter, solute receptor (TAXI family
BTL49_RS00510	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BTL49_RS00525	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BTL49_RS00530	COG0183	Belongs to the thiolase family
BTL49_RS00535	COG1960	acyl-CoA dehydrogenase activity
BTL49_RS00560	COG2200	EAL domain
BTL49_RS00565	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BTL49_RS00575	COG0018	arginyl-trna synthetase
BTL49_RS00590	COG0154	amidase activity
BTL49_RS00595	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BTL49_RS00605	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
BTL49_RS00615	COG0697	spore germination
BTL49_RS00675	COG3350	monooxygenase activity
BTL49_RS00700	COG1309	transcriptional regulator
BTL49_RS00730	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
BTL49_RS00735	COG1280	lysine exporter protein (LysE YggA)
BTL49_RS00740	COG0513	Belongs to the DEAD box helicase family
BTL49_RS00750	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
BTL49_RS00755	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BTL49_RS00785	COG2969	positive regulation of protein catabolic process
BTL49_RS00790	COG0625	glutathione transferase activity
BTL49_RS00795	COG2857	Cytochrome c1
BTL49_RS00800	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BTL49_RS00805	COG0723	plastoquinol--plastocyanin reductase activity
BTL49_RS00810	COG1970	mechanosensitive ion channel activity
BTL49_RS00815	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BTL49_RS00820	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BTL49_RS00830	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BTL49_RS00835	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BTL49_RS00845	COG0140	phosphoribosyl-ATP diphosphatase activity
BTL49_RS00850	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BTL49_RS00855	COG0107	imidazoleglycerol-phosphate synthase activity
BTL49_RS00860	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BTL49_RS00870	COG0131	Imidazoleglycerol-phosphate dehydratase
BTL49_RS00875	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BTL49_RS00880	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
BTL49_RS00885	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BTL49_RS00890	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BTL49_RS00900	COG0842	Transport permease protein
BTL49_RS00905	COG1131	(ABC) transporter
BTL49_RS00920	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BTL49_RS00925	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BTL49_RS00930	COG1127	ABC transporter
BTL49_RS00950	COG0069	glutamate synthase activity
BTL49_RS00950	COG0067	glutamate synthase
BTL49_RS00950	COG0070	glutamate synthase
BTL49_RS00975	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
BTL49_RS01000	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BTL49_RS01005	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
BTL49_RS01045	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BTL49_RS01080	COG0109	protoheme IX farnesyltransferase activity
BTL49_RS01085	COG1999	signal sequence binding
BTL49_RS01105	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BTL49_RS01110	COG2814	Major facilitator Superfamily
BTL49_RS01125	COG1522	sequence-specific DNA binding
BTL49_RS01185	COG4948	Mandelate Racemase Muconate Lactonizing
BTL49_RS01200	COG3119	arylsulfatase activity
BTL49_RS01240	COG0402	S-adenosylhomocysteine deaminase activity
BTL49_RS01250	COG1304	FMN binding
BTL49_RS01255	COG1254	Belongs to the acylphosphatase family
BTL49_RS01265	COG3181	Tripartite tricarboxylate transporter family receptor
BTL49_RS01275	COG1414	Transcriptional regulator
BTL49_RS01295	COG0028	Belongs to the TPP enzyme family
BTL49_RS01300	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
BTL49_RS01305	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BTL49_RS01310	COG1960	acyl-CoA dehydrogenase activity
BTL49_RS01345	COG3181	Tripartite tricarboxylate transporter family receptor
BTL49_RS01350	COG0583	DNA-binding transcription factor activity
BTL49_RS01365	COG0129	dihydroxy-acid dehydratase activity
BTL49_RS01370	COG2084	Dehydrogenase
BTL49_RS01385	COG1671	Belongs to the UPF0178 family
BTL49_RS01390	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
BTL49_RS01405	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
BTL49_RS01410	COG0443	Heat shock 70 kDa protein
BTL49_RS01435	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BTL49_RS01435	COG2169	Transcriptional regulator
BTL49_RS01450	COG1683	Conserved Protein
BTL49_RS01455	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BTL49_RS01470	COG1120	ATPase activity
BTL49_RS01475	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BTL49_RS01480	COG4558	Periplasmic binding protein
BTL49_RS01485	COG3720	iron ion transport
BTL49_RS01495	COG3712	iron ion homeostasis
BTL49_RS01500	COG1595	DNA-templated transcription, initiation
BTL49_RS01520	COG1607	acyl-coa hydrolase
BTL49_RS01530	COG0243	molybdopterin cofactor binding
BTL49_RS01530	COG3383	formate dehydrogenase (NAD+) activity
BTL49_RS01535	COG0243	molybdopterin cofactor binding
BTL49_RS01535	COG3383	formate dehydrogenase (NAD+) activity
BTL49_RS01540	COG0437	4 iron, 4 sulfur cluster binding
BTL49_RS01545	COG2864	formate dehydrogenase
BTL49_RS01560	COG3276	selenocysteine insertion sequence binding
BTL49_RS01595	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BTL49_RS01600	COG0512	Glutamine amidotransferase of anthranilate synthase
BTL49_RS01610	COG0546	phosphoglycolate phosphatase activity
BTL49_RS01615	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BTL49_RS01620	COG2967	ApaG domain
BTL49_RS01625	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
BTL49_RS01630	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BTL49_RS01635	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BTL49_RS01640	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BTL49_RS01645	COG0037	tRNA processing
BTL49_RS01665	COG1024	Enoyl-CoA hydratase
BTL49_RS01680	COG0356	it plays a direct role in the translocation of protons across the membrane
BTL49_RS01690	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BTL49_RS01695	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BTL49_RS01700	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BTL49_RS01705	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BTL49_RS01710	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BTL49_RS01715	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BTL49_RS01745	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
BTL49_RS01750	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BTL49_RS01755	COG0210	DNA helicase
BTL49_RS01770	COG4608	Belongs to the ABC transporter superfamily
BTL49_RS01775	COG0444	Belongs to the ABC transporter superfamily
BTL49_RS01780	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BTL49_RS01805	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BTL49_RS01810	COG1024	Enoyl-CoA hydratase
BTL49_RS01815	COG1024	Enoyl-CoA hydratase
BTL49_RS01820	COG2070	2-Nitropropane dioxygenase
BTL49_RS01835	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BTL49_RS01840	COG1250	3-hydroxyacyl-CoA dehydrogenase
BTL49_RS01860	COG2267	carboxylic ester hydrolase activity
BTL49_RS01880	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
BTL49_RS01890	COG2813	Specifically methylates the guanine in position
BTL49_RS01890	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BTL49_RS01895	COG2223	nitrite transmembrane transporter activity
BTL49_RS01900	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
BTL49_RS01915	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BTL49_RS01920	COG0708	Exodeoxyribonuclease III
BTL49_RS01925	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BTL49_RS01930	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BTL49_RS01935	COG0154	amidase activity
BTL49_RS01940	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BTL49_RS01945	COG1077	Cell shape determining protein MreB Mrl
BTL49_RS01950	COG1792	Involved in formation and maintenance of cell shape
BTL49_RS01960	COG0768	penicillin binding
BTL49_RS01965	COG0772	Belongs to the SEDS family
BTL49_RS01970	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
BTL49_RS01975	COG0471	metal ion transport
BTL49_RS01980	COG1309	transcriptional regulator
BTL49_RS01990	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BTL49_RS02005	COG2823	Periplasmic or secreted lipoprotein
BTL49_RS02010	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
BTL49_RS02015	COG0792	nuclease activity
BTL49_RS02035	COG1660	Displays ATPase and GTPase activities
BTL49_RS02050	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
BTL49_RS02060	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
BTL49_RS02070	COG3181	Tripartite tricarboxylate transporter family receptor
BTL49_RS02075	COG1473	amidohydrolase
BTL49_RS02080	COG1137	ATPase activity
BTL49_RS02095	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
BTL49_RS02105	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
BTL49_RS02125	COG1294	oxidase, subunit
BTL49_RS02135	COG4988	ABC transporter
BTL49_RS02140	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BTL49_RS02145	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BTL49_RS02160	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BTL49_RS02165	COG1238	metal cluster binding
BTL49_RS02185	COG1984	allophanate hydrolase subunit 2
BTL49_RS02190	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
BTL49_RS02200	COG0583	DNA-binding transcription factor activity
BTL49_RS02205	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BTL49_RS02210	COG5002	protein histidine kinase activity
BTL49_RS02215	COG0745	RESPONSE REGULATOR receiver
BTL49_RS02220	COG2226	methyltransferase
BTL49_RS02265	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BTL49_RS02275	COG1028	Short-chain dehydrogenase reductase Sdr
BTL49_RS02295	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BTL49_RS02300	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BTL49_RS02310	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BTL49_RS02330	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
BTL49_RS02335	COG1538	Outer membrane efflux protein
BTL49_RS02345	COG0351	phosphomethylpyrimidine kinase
BTL49_RS02350	COG2022	thiamine diphosphate biosynthetic process
BTL49_RS02355	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BTL49_RS02375	COG2226	methyltransferase
BTL49_RS02385	COG1194	a g-specific adenine glycosylase
BTL49_RS02395	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
BTL49_RS02400	COG2177	Part of the ABC transporter FtsEX involved in
BTL49_RS02405	COG2884	Cell division ATP-binding protein ftsE
BTL49_RS02410	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BTL49_RS02415	COG4597	amino acid ABC transporter
BTL49_RS02420	COG0765	amino acid transport
BTL49_RS02425	COG1126	abc transporter atp-binding protein
BTL49_RS02455	COG0477	Major facilitator Superfamily
BTL49_RS02465	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
BTL49_RS02470	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
BTL49_RS02485	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
BTL49_RS02490	COG0237	dephospho-CoA kinase activity
BTL49_RS02495	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
BTL49_RS02505	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BTL49_RS02520	COG3539	Fimbrial protein
BTL49_RS02525	COG3539	Fimbrial protein
BTL49_RS02540	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
BTL49_RS02550	COG1846	Transcriptional regulator
BTL49_RS02615	COG1028	Short-chain dehydrogenase reductase Sdr
BTL49_RS02620	COG1024	Enoyl-CoA hydratase
BTL49_RS02625	COG1960	acyl-CoA dehydrogenase activity
BTL49_RS02655	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BTL49_RS02660	COG0352	thiamine-phosphate diphosphorylase activity
BTL49_RS02665	COG0351	phosphomethylpyrimidine kinase
BTL49_RS02675	COG1678	Uncharacterized ACR, COG1678
BTL49_RS02680	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BTL49_RS02705	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BTL49_RS02715	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BTL49_RS02720	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BTL49_RS02730	COG0557	exoribonuclease II activity
BTL49_RS02740	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BTL49_RS02745	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BTL49_RS02750	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BTL49_RS02760	COG0439	Biotin carboxylase
BTL49_RS02765	COG2264	protein methyltransferase activity
BTL49_RS02775	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BTL49_RS02800	COG1696	Membrane protein involved in D-alanine export
BTL49_RS02805	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BTL49_RS02845	COG1522	sequence-specific DNA binding
BTL49_RS02860	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BTL49_RS02925	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BTL49_RS02950	COG3028	Belongs to the UPF0307 family
BTL49_RS02955	COG0312	modulator of DNA gyrase
BTL49_RS02960	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BTL49_RS02965	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BTL49_RS02970	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
BTL49_RS02980	COG0316	Belongs to the HesB IscA family
BTL49_RS02990	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
BTL49_RS03000	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BTL49_RS03005	COG1881	PFAM PEBP family protein
BTL49_RS03010	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BTL49_RS03015	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BTL49_RS03030	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BTL49_RS03030	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BTL49_RS03045	COG2718	Belongs to the UPF0229 family
BTL49_RS03050	COG2719	SpoVR family
BTL49_RS03115	COG0165	Argininosuccinate lyase
BTL49_RS03120	COG0589	response to stress
BTL49_RS03130	COG2816	NAD+ diphosphatase activity
BTL49_RS03135	COG4993	Dehydrogenase
BTL49_RS03160	COG3181	Tripartite tricarboxylate transporter family receptor
BTL49_RS03165	COG2979	Protein of unknown function (DUF533)
BTL49_RS03170	COG4206	TonB-dependent receptor
BTL49_RS03185	COG0741	lytic transglycosylase activity
BTL49_RS03185	COG1388	LysM domain
BTL49_RS03190	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BTL49_RS03195	COG2226	methyltransferase
BTL49_RS03200	COG0328	RNA-DNA hybrid ribonuclease activity
BTL49_RS03225	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BTL49_RS03245	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BTL49_RS03250	COG1129	ABC transporter
BTL49_RS03250	COG0842	Transport permease protein
BTL49_RS03255	COG0842	Transport permease protein
BTL49_RS03275	COG0463	Glycosyl transferase, family 2
BTL49_RS03280	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
BTL49_RS03295	COG1073	alpha beta
BTL49_RS03305	COG0697	spore germination
BTL49_RS03310	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BTL49_RS03335	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BTL49_RS03365	COG0823	Involved in the tonB-independent uptake of proteins
BTL49_RS03375	COG0848	biopolymer transport protein
BTL49_RS03380	COG0811	peptide transport
BTL49_RS03385	COG0824	Thioesterase
BTL49_RS03390	COG0442	prolyl-tRNA aminoacylation
BTL49_RS03435	COG2084	Dehydrogenase
BTL49_RS03480	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BTL49_RS03485	COG4654	Cytochrome c, class I
BTL49_RS03490	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BTL49_RS03555	COG1473	amidohydrolase
BTL49_RS03560	COG0418	dihydroorotase activity
BTL49_RS03565	COG0488	(ABC) transporter
BTL49_RS03575	COG2001	Belongs to the MraZ family
BTL49_RS03580	COG0275	rRNA processing
BTL49_RS03585	COG3116	cell division
BTL49_RS03595	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BTL49_RS03600	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BTL49_RS03605	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BTL49_RS03615	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BTL49_RS03620	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BTL49_RS03625	COG1181	Belongs to the D-alanine--D-alanine ligase family
BTL49_RS03630	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BTL49_RS03645	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
BTL49_RS03660	COG0739	heme binding
BTL49_RS03665	COG0653	protein targeting
BTL49_RS03690	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
BTL49_RS03695	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BTL49_RS03705	COG0828	Belongs to the bacterial ribosomal protein bS21 family
BTL49_RS03745	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
BTL49_RS03760	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
BTL49_RS03785	COG0583	DNA-binding transcription factor activity
BTL49_RS03795	COG3181	Tripartite tricarboxylate transporter family receptor
BTL49_RS03800	COG2084	Dehydrogenase
BTL49_RS03810	COG1597	lipid kinase activity
BTL49_RS03810	COG1803	Methylglyoxal synthase
BTL49_RS03820	COG0671	phosphoesterase, PA-phosphatase related
BTL49_RS03840	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
BTL49_RS03845	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BTL49_RS03850	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BTL49_RS03855	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BTL49_RS03860	COG0649	NAD binding
BTL49_RS03865	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
BTL49_RS03875	COG1034	ATP synthesis coupled electron transport
BTL49_RS03880	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
BTL49_RS03885	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BTL49_RS03895	COG0713	ATP synthesis coupled electron transport
BTL49_RS03910	COG1007	ATP synthesis coupled electron transport
BTL49_RS03920	COG0560	Phosphoserine phosphatase
BTL49_RS03925	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BTL49_RS03930	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
BTL49_RS03935	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BTL49_RS03950	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BTL49_RS03955	COG0450	alkyl hydroperoxide reductase
BTL49_RS03975	COG1214	PFAM Peptidase M22, glycoprotease
BTL49_RS03980	COG1573	uracil-dna glycosylase
BTL49_RS03985	COG0477	Major facilitator Superfamily
BTL49_RS03990	COG1196	nuclear chromosome segregation
BTL49_RS04000	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BTL49_RS04005	COG1126	abc transporter atp-binding protein
BTL49_RS04010	COG0765	amino acid transport
BTL49_RS04015	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BTL49_RS04020	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BTL49_RS04025	COG2917	probably involved in intracellular septation
BTL49_RS04030	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BTL49_RS04035	COG1122	ATPase activity
BTL49_RS04040	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
BTL49_RS04075	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BTL49_RS04100	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BTL49_RS04105	COG2878	Part of a membrane complex involved in electron transport
BTL49_RS04125	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
BTL49_RS04130	COG0251	oxidation-reduction process
BTL49_RS04140	COG3228	Belongs to the MtfA family
BTL49_RS04145	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BTL49_RS04155	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BTL49_RS04165	COG0159	tryptophan synthase activity
BTL49_RS04170	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
BTL49_RS04175	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
BTL49_RS04190	COG1530	ribonuclease E activity
BTL49_RS04195	COG0564	pseudouridine synthase activity
BTL49_RS04200	COG0546	phosphoglycolate phosphatase activity
BTL49_RS04205	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BTL49_RS04210	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
BTL49_RS04215	COG3023	N-Acetylmuramoyl-L-alanine amidase
BTL49_RS04225	COG0424	maF-like protein
BTL49_RS04235	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BTL49_RS04245	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BTL49_RS04255	COG1028	Short-chain dehydrogenase reductase Sdr
BTL49_RS04260	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BTL49_RS04265	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BTL49_RS04290	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BTL49_RS04310	COG0481	GTPase activity
BTL49_RS04315	COG0681	Belongs to the peptidase S26 family
BTL49_RS04320	COG0571	ribonuclease III activity
BTL49_RS04325	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BTL49_RS04330	COG1381	Involved in DNA repair and RecF pathway recombination
BTL49_RS04350	COG0670	Belongs to the BI1 family
BTL49_RS04365	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BTL49_RS04390	COG0583	DNA-binding transcription factor activity
BTL49_RS04410	COG0791	NLP P60 protein
BTL49_RS04415	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BTL49_RS04420	COG3193	protein, possibly involved in utilization of glycolate and propanediol
BTL49_RS04430	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BTL49_RS04450	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
BTL49_RS04485	COG1446	asparaginase
BTL49_RS04490	COG4172	Belongs to the ABC transporter superfamily
BTL49_RS04495	COG0747	negative chemotaxis
BTL49_RS04500	COG0601	transmembrane transport
BTL49_RS04525	COG0504	CTP synthase activity
BTL49_RS04535	COG0148	phosphopyruvate hydratase activity
BTL49_RS04550	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BTL49_RS04560	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BTL49_RS04565	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BTL49_RS04610	COG1981	membrane
BTL49_RS04630	COG0039	L-malate dehydrogenase activity
BTL49_RS04635	COG2188	Transcriptional regulator
BTL49_RS04640	COG2009	succinate dehydrogenase
BTL49_RS04645	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
BTL49_RS04650	COG1053	succinate dehydrogenase
BTL49_RS04655	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BTL49_RS04660	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
BTL49_RS04665	COG0372	Belongs to the citrate synthase family
BTL49_RS04680	COG0583	DNA-binding transcription factor activity
BTL49_RS04685	COG3842	ATPase activity
BTL49_RS04705	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BTL49_RS04715	COG3128	pkhd-type hydroxylase
BTL49_RS04720	COG4774	siderophore transport
BTL49_RS04730	COG0280	phosphate acetyltransferase
BTL49_RS04730	COG0281	malic enzyme
BTL49_RS04740	COG1297	OPT oligopeptide transporter protein
BTL49_RS04745	COG0567	Dehydrogenase, E1 component
BTL49_RS04750	COG0508	dehydrogenase complex catalyzes the overall conversion of
BTL49_RS04755	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BTL49_RS04760	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
BTL49_RS04765	COG1595	DNA-templated transcription, initiation
BTL49_RS04775	COG4774	siderophore transport
BTL49_RS04800	COG2183	response to ionizing radiation
BTL49_RS04805	COG1199	ATP-dependent helicase activity
BTL49_RS04815	COG0564	pseudouridine synthase activity
BTL49_RS04825	COG3243	poly(R)-hydroxyalkanoic acid synthase
BTL49_RS04830	COG1028	Short-chain dehydrogenase reductase Sdr
BTL49_RS04835	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
BTL49_RS04850	COG0672	)-iron permease
BTL49_RS04865	COG2823	Periplasmic or secreted lipoprotein
BTL49_RS04885	COG3237	CsbD-like
BTL49_RS04890	COG3038	cytochrome b561
BTL49_RS04905	COG1132	(ABC) transporter
BTL49_RS04920	COG2833	Protein of unknown function (DUF455)
BTL49_RS04925	COG2951	lytic endotransglycosylase activity
BTL49_RS04950	COG0586	Pfam SNARE associated Golgi protein
BTL49_RS05000	COG0165	Argininosuccinate lyase
BTL49_RS05020	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BTL49_RS05035	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BTL49_RS05040	COG1605	Chorismate mutase
BTL49_RS05040	COG0077	Prephenate dehydratase
BTL49_RS05045	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BTL49_RS05055	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BTL49_RS05060	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BTL49_RS05080	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
BTL49_RS05085	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
BTL49_RS05090	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BTL49_RS05095	COG0587	DNA-directed DNA polymerase activity
BTL49_RS05105	COG2951	lytic endotransglycosylase activity
BTL49_RS05110	COG0123	including yeast histone deacetylase and acetoin utilization protein
BTL49_RS05125	COG2985	domain, Protein
BTL49_RS05130	COG1960	acyl-CoA dehydrogenase activity
BTL49_RS05135	COG0450	alkyl hydroperoxide reductase
BTL49_RS05140	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
BTL49_RS05145	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
BTL49_RS05150	COG4208	sulfate ABC transporter
BTL49_RS05155	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
BTL49_RS05160	COG0175	sulfate reduction
BTL49_RS05185	COG0335	large ribosomal subunit rRNA binding
BTL49_RS05205	COG3622	Belongs to the hyi family
BTL49_RS05210	COG1162	GTPase activity
BTL49_RS05215	COG0501	Belongs to the peptidase M48B family
BTL49_RS05220	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
BTL49_RS05225	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
BTL49_RS05230	COG3327	negative regulation of DNA-templated transcription, initiation
BTL49_RS05235	COG3396	Phenylacetate-CoA oxygenase
BTL49_RS05240	COG3460	Phenylacetate-CoA oxygenase
BTL49_RS05245	COG3396	Phenylacetate-CoA oxygenase
BTL49_RS05250	COG2151	metal-sulfur cluster biosynthetic enzyme
BTL49_RS05255	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BTL49_RS05260	COG1012	belongs to the aldehyde dehydrogenase family
BTL49_RS05265	COG1024	Enoyl-CoA hydratase
BTL49_RS05270	COG2050	protein possibly involved in aromatic compounds catabolism
BTL49_RS05305	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BTL49_RS05305	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BTL49_RS05315	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BTL49_RS05320	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
BTL49_RS05325	COG2346	COG2346, Truncated hemoglobins
BTL49_RS05330	COG3642	lipopolysaccharide core region biosynthetic process
BTL49_RS05340	COG3842	ATPase activity
BTL49_RS05345	COG1176	ABC-type spermidine putrescine transport system, permease component I
BTL49_RS05350	COG1177	transmembrane transport
BTL49_RS05370	COG1322	Protein conserved in bacteria
BTL49_RS05380	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
BTL49_RS05385	COG0704	Plays a role in the regulation of phosphate uptake
BTL49_RS05390	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
BTL49_RS05395	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BTL49_RS05395	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
BTL49_RS05400	COG1643	Atp-dependent helicase
BTL49_RS05415	COG0438	transferase activity, transferring glycosyl groups
BTL49_RS05420	COG0726	polysaccharide deacetylase
BTL49_RS05425	COG0463	Glycosyl transferase, family 2
BTL49_RS05460	COG1132	(ABC) transporter
BTL49_RS05480	COG0501	Belongs to the peptidase M48B family
BTL49_RS05530	COG1722	exodeoxyribonuclease VII activity
BTL49_RS05535	COG0142	geranyltranstransferase activity
BTL49_RS05540	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BTL49_RS05545	COG1469	GTP cyclohydrolase I activity
BTL49_RS05550	COG0360	Binds together with S18 to 16S ribosomal RNA
BTL49_RS05555	COG2965	DNA replication, synthesis of RNA primer
BTL49_RS05560	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BTL49_RS05565	COG0359	binds to the 23S rRNA
BTL49_RS05575	COG0305	Participates in initiation and elongation during chromosome replication
BTL49_RS05595	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
BTL49_RS05600	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
BTL49_RS05605	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BTL49_RS05610	COG3737	Protein of unknown function (DUF498/DUF598)
BTL49_RS05615	COG0436	Aminotransferase
BTL49_RS05640	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
BTL49_RS05645	COG0308	aminopeptidase N
BTL49_RS05660	COG0312	modulator of DNA gyrase
BTL49_RS05665	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BTL49_RS05690	COG0277	FAD linked oxidase domain protein
BTL49_RS05695	COG0277	FAD linked oxidase domain protein
BTL49_RS05700	COG0247	lactate metabolic process
BTL49_RS05740	COG0583	DNA-binding transcription factor activity
BTL49_RS05745	COG0482	sulfurtransferase activity
BTL49_RS05750	COG0730	response to heat
BTL49_RS05755	COG0625	glutathione transferase activity
BTL49_RS05760	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BTL49_RS05765	COG3909	cytochrome
BTL49_RS05800	COG3706	GGDEF domain
BTL49_RS05815	COG2826	transposase and inactivated derivatives, IS30 family
BTL49_RS05835	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
BTL49_RS05860	COG0069	glutamate synthase activity
BTL49_RS05865	COG2391	methyltransferase activity
BTL49_RS05870	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
BTL49_RS05875	COG0679	Auxin Efflux Carrier
BTL49_RS05880	COG2153	protein acetylation
BTL49_RS05900	COG0557	exoribonuclease II activity
BTL49_RS05905	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BTL49_RS05910	COG2873	o-acetylhomoserine
BTL49_RS05915	COG0776	regulation of translation
BTL49_RS05945	COG0642	Histidine kinase
BTL49_RS05950	COG3158	transport of potassium into the cell
BTL49_RS05975	COG0137	argininosuccinate synthase activity
BTL49_RS05980	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BTL49_RS05985	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BTL49_RS05995	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BTL49_RS06010	COG2186	Transcriptional regulator
BTL49_RS06045	COG3836	Belongs to the HpcH HpaI aldolase family
BTL49_RS06050	COG0268	Binds directly to 16S ribosomal RNA
BTL49_RS06100	COG0728	peptidoglycan biosynthetic process
BTL49_RS06110	COG0563	adenylate kinase activity
BTL49_RS06115	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
BTL49_RS06120	COG2835	tetraacyldisaccharide 4'-kinase activity
BTL49_RS06125	COG1663	tetraacyldisaccharide 4'-kinase activity
BTL49_RS06130	COG0848	biopolymer transport protein
BTL49_RS06135	COG0811	peptide transport
BTL49_RS06140	COG1570	exodeoxyribonuclease VII activity
BTL49_RS06145	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BTL49_RS06155	COG0038	chloride channel
BTL49_RS06160	COG0183	Belongs to the thiolase family
BTL49_RS06170	COG1278	Cold shock
BTL49_RS06175	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
BTL49_RS06185	COG4953	penicillin-binding protein 1C
BTL49_RS06200	COG3008	intermembrane lipid transfer
BTL49_RS06210	COG0506	proline dehydrogenase activity
BTL49_RS06210	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
BTL49_RS06210	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
BTL49_RS06245	COG0004	ammonium transporteR
BTL49_RS06250	COG0347	Belongs to the P(II) protein family
BTL49_RS06300	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BTL49_RS06305	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BTL49_RS06310	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BTL49_RS06315	COG0072	phenylalanine-tRNA ligase activity
BTL49_RS06315	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BTL49_RS06320	COG0776	regulation of translation
BTL49_RS06350	COG1802	Transcriptional regulator
BTL49_RS06355	COG3181	Tripartite tricarboxylate transporter family receptor
BTL49_RS06375	COG1278	Cold shock
BTL49_RS06385	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BTL49_RS06405	COG1522	sequence-specific DNA binding
BTL49_RS06455	COG5265	(ABC) transporter
BTL49_RS06475	COG0656	L-ascorbic acid biosynthetic process
BTL49_RS06480	COG0667	Aldo Keto reductase
BTL49_RS06495	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BTL49_RS06540	COG1610	YqeY-like protein
BTL49_RS06555	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BTL49_RS06560	COG3246	L-lysine catabolic process to acetate
BTL49_RS06580	COG0318	PFAM AMP-dependent synthetase and ligase
BTL49_RS06595	COG0183	Belongs to the thiolase family
BTL49_RS06600	COG1024	Enoyl-CoA hydratase
BTL49_RS06600	COG1250	3-hydroxyacyl-CoA dehydrogenase
BTL49_RS06610	COG1024	Enoyl-CoA hydratase
BTL49_RS06610	COG1250	3-hydroxyacyl-CoA dehydrogenase
BTL49_RS06615	COG0183	Belongs to the thiolase family
BTL49_RS06620	COG1960	acyl-CoA dehydrogenase activity
BTL49_RS06630	COG1045	serine acetyltransferase
BTL49_RS06640	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BTL49_RS06645	COG0483	inositol monophosphate 1-phosphatase activity
BTL49_RS06650	COG1012	belongs to the aldehyde dehydrogenase family
BTL49_RS06655	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
BTL49_RS06670	COG0210	DNA helicase
BTL49_RS06675	COG0598	Magnesium transport protein CorA
BTL49_RS06685	COG0747	negative chemotaxis
BTL49_RS06690	COG0601	transmembrane transport
BTL49_RS06695	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BTL49_RS06700	COG4172	Belongs to the ABC transporter superfamily
BTL49_RS06720	COG1346	cytolysis
BTL49_RS06730	COG1028	Short-chain dehydrogenase reductase Sdr
BTL49_RS06735	COG0783	Belongs to the Dps family
BTL49_RS06755	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
BTL49_RS06765	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BTL49_RS06770	COG1845	cytochrome c oxidase, subunit III
BTL49_RS06775	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
BTL49_RS06820	COG1666	GTP binding
BTL49_RS06845	COG1028	Short-chain dehydrogenase reductase Sdr
BTL49_RS06850	COG5006	permease, DMT superfamily
BTL49_RS06875	COG2264	protein methyltransferase activity
BTL49_RS06910	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BTL49_RS06915	COG0746	molybdenum cofactor guanylyltransferase activity
BTL49_RS06920	COG0303	'Molybdopterin
BTL49_RS06925	COG0521	Mo-molybdopterin cofactor biosynthetic process
BTL49_RS06930	COG0314	molybdopterin synthase activity
BTL49_RS06940	COG0315	cyclic pyranopterin monophosphate synthase activity
BTL49_RS06945	COG0412	Dienelactone hydrolase
BTL49_RS06955	COG0678	peroxiredoxin activity
BTL49_RS06970	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BTL49_RS06980	COG0542	response to heat
BTL49_RS06990	COG1477	protein flavinylation
BTL49_RS07015	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BTL49_RS07020	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
BTL49_RS07020	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
BTL49_RS07025	COG1562	ergosterol biosynthetic process
BTL49_RS07030	COG1562	ergosterol biosynthetic process
BTL49_RS07035	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BTL49_RS07075	COG0254	rRNA binding
BTL49_RS07080	COG3483	tryptophan 2,3-dioxygenase activity
BTL49_RS07085	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
BTL49_RS07090	COG2003	Belongs to the UPF0758 family
BTL49_RS07100	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BTL49_RS07105	COG0625	glutathione transferase activity
BTL49_RS07125	COG0523	cobalamin synthesis protein
BTL49_RS07135	COG0583	DNA-binding transcription factor activity
BTL49_RS07145	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BTL49_RS07150	COG1187	pseudouridine synthase activity
BTL49_RS07155	COG0779	Required for maturation of 30S ribosomal subunits
BTL49_RS07160	COG2251	uridine kinase activity
BTL49_RS07160	COG0195	Participates in both transcription termination and antitermination
BTL49_RS07165	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BTL49_RS07170	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BTL49_RS07175	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BTL49_RS07180	COG1217	gtp-binding protein TYPA
BTL49_RS07195	COG1802	Transcriptional regulator
BTL49_RS07205	COG1024	Enoyl-CoA hydratase
BTL49_RS07210	COG0318	PFAM AMP-dependent synthetase and ligase
BTL49_RS07220	COG2032	superoxide dismutase activity
BTL49_RS07235	COG4120	Belongs to the binding-protein-dependent transport system permease family
BTL49_RS07240	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
BTL49_RS07245	COG0725	ABC transporter, periplasmic molybdate-binding protein
BTL49_RS07250	COG4149	molybdate abc transporter
BTL49_RS07280	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BTL49_RS07285	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BTL49_RS07290	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BTL49_RS07300	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
BTL49_RS07305	COG0736	holo-[acyl-carrier-protein] synthase activity
BTL49_RS07310	COG1472	Belongs to the glycosyl hydrolase 3 family
BTL49_RS07315	COG0322	excinuclease ABC activity
BTL49_RS07320	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BTL49_RS07330	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BTL49_RS07330	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BTL49_RS07335	COG2224	Isocitrate lyase
BTL49_RS07340	COG1846	Transcriptional regulator
BTL49_RS07345	COG1764	response to oxidative stress
BTL49_RS07350	COG1131	(ABC) transporter
BTL49_RS07360	COG0628	permease
BTL49_RS07375	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
BTL49_RS07385	COG2814	Major facilitator Superfamily
BTL49_RS07405	COG3015	lipoprotein NlpE involved in copper resistance
BTL49_RS07415	COG3530	Putative quorum-sensing-regulated virulence factor
BTL49_RS07430	COG0494	nUDIX hydrolase
BTL49_RS07440	COG0697	spore germination
BTL49_RS07445	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BTL49_RS07470	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BTL49_RS07475	COG1702	phosphate starvation-inducible protein PhoH
BTL49_RS07480	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BTL49_RS07485	COG4535	Mg2 and Co2 transporter CorC
BTL49_RS07490	COG0815	Transfers the fatty acyl group on membrane lipoproteins
BTL49_RS07495	COG0667	Aldo Keto reductase
BTL49_RS07515	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BTL49_RS07520	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BTL49_RS07525	COG1862	Preprotein translocase
BTL49_RS07530	COG0343	queuine tRNA-ribosyltransferase activity
BTL49_RS07535	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BTL49_RS07540	COG2027	D-alanyl-D-alanine carboxypeptidase
BTL49_RS07545	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BTL49_RS07550	COG1648	precorrin-2 dehydrogenase activity
BTL49_RS07550	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BTL49_RS07560	COG4575	ribosome binding
BTL49_RS07585	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
BTL49_RS07590	COG0741	lytic transglycosylase activity
BTL49_RS07595	COG0436	Aminotransferase
BTL49_RS07605	COG0280	phosphate acetyltransferase
BTL49_RS07605	COG0281	malic enzyme
BTL49_RS07620	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BTL49_RS07625	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BTL49_RS07630	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BTL49_RS07635	COG0126	phosphoglycerate kinase activity
BTL49_RS07650	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BTL49_RS07665	COG0625	glutathione transferase activity
BTL49_RS07685	COG0789	Transcriptional regulator
BTL49_RS07700	COG0306	phosphate transporter
BTL49_RS07705	COG0521	Mo-molybdopterin cofactor biosynthetic process
BTL49_RS07715	COG0739	heme binding
BTL49_RS07725	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BTL49_RS07765	COG0456	acetyltransferase
BTL49_RS07770	COG1301	dicarboxylic acid transport
BTL49_RS07780	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
BTL49_RS07785	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BTL49_RS07790	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BTL49_RS07795	COG0009	L-threonylcarbamoyladenylate synthase
BTL49_RS07805	COG4771	TonB-dependent receptor
BTL49_RS07835	COG1960	acyl-CoA dehydrogenase activity
BTL49_RS07840	COG0028	Belongs to the TPP enzyme family
BTL49_RS07850	COG0583	DNA-binding transcription factor activity
BTL49_RS07855	COG4974	Belongs to the 'phage' integrase family
BTL49_RS07860	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BTL49_RS07865	COG1686	Belongs to the peptidase S11 family
BTL49_RS07895	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BTL49_RS07900	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BTL49_RS07905	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BTL49_RS07925	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BTL49_RS07930	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BTL49_RS07935	COG0505	Belongs to the CarA family
BTL49_RS07940	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BTL49_RS07950	COG1028	Short-chain dehydrogenase reductase Sdr
BTL49_RS07955	COG0406	alpha-ribazole phosphatase activity
BTL49_RS07985	COG2233	PERMEase
BTL49_RS07990	COG3620	sequence-specific DNA binding
BTL49_RS08005	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BTL49_RS08015	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
BTL49_RS08020	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BTL49_RS08030	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BTL49_RS08045	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BTL49_RS08065	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BTL49_RS08125	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BTL49_RS08160	COG0540	Belongs to the ATCase OTCase family
BTL49_RS08165	COG2974	May be involved in recombination
BTL49_RS08190	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BTL49_RS08195	COG2137	regulation of response to DNA damage stimulus
BTL49_RS08205	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BTL49_RS08225	COG0045	succinate-CoA ligase (ADP-forming) activity
BTL49_RS08230	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BTL49_RS08235	COG0861	Integral membrane protein TerC family
BTL49_RS08240	COG0861	Integral membrane protein TerC family
BTL49_RS08245	COG0181	hydroxymethylbilane synthase activity
BTL49_RS08285	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BTL49_RS08330	COG1450	Type ii and iii secretion system protein
BTL49_RS08375	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BTL49_RS08385	COG1295	ribonuclease BN
BTL49_RS08395	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
BTL49_RS08415	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BTL49_RS08420	COG0501	Belongs to the peptidase M48B family
BTL49_RS08425	COG2197	response regulator
BTL49_RS08450	COG0066	3-isopropylmalate dehydratase activity
BTL49_RS08465	COG0473	3-isopropylmalate dehydrogenase activity
BTL49_RS08470	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BTL49_RS08480	COG0101	tRNA pseudouridine synthase activity
BTL49_RS08485	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
BTL49_RS08490	COG0135	phosphoribosylanthranilate isomerase activity
BTL49_RS08510	COG2801	Transposase and inactivated derivatives
BTL49_RS08515	COG2801	Transposase and inactivated derivatives
BTL49_RS08550	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BTL49_RS08555	COG2197	response regulator
BTL49_RS08560	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BTL49_RS08565	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BTL49_RS08580	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BTL49_RS08585	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BTL49_RS08595	COG1764	response to oxidative stress
BTL49_RS08610	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BTL49_RS08615	COG0765	amino acid transport
BTL49_RS08620	COG0765	amino acid transport
BTL49_RS08625	COG1126	abc transporter atp-binding protein
BTL49_RS08630	COG0756	dUTP diphosphatase activity
BTL49_RS08660	COG1522	sequence-specific DNA binding
BTL49_RS08680	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BTL49_RS08685	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BTL49_RS08690	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BTL49_RS08695	COG0196	riboflavin kinase activity
BTL49_RS08705	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BTL49_RS08705	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BTL49_RS08745	COG2814	Major facilitator Superfamily
BTL49_RS08775	COG3486	L-lysine 6-monooxygenase (NADPH) activity
BTL49_RS08790	COG1028	Short-chain dehydrogenase reductase Sdr
BTL49_RS08800	COG3022	response to hydroperoxide
BTL49_RS08825	COG0028	Belongs to the TPP enzyme family
BTL49_RS08830	COG0440	acetolactate synthase activity
BTL49_RS08840	COG1183	phosphatidylcholine synthase activity
BTL49_RS08855	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BTL49_RS08860	COG1185	polyribonucleotide nucleotidyltransferase activity
BTL49_RS08890	COG0583	DNA-binding transcription factor activity
BTL49_RS08905	COG1129	ABC transporter
BTL49_RS08940	COG1280	lysine exporter protein (LysE YggA)
BTL49_RS08955	COG3161	chorismate lyase activity
BTL49_RS08960	COG1187	pseudouridine synthase activity
BTL49_RS08965	COG0583	DNA-binding transcription factor activity
BTL49_RS08970	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BTL49_RS08990	COG1999	signal sequence binding
BTL49_RS09010	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BTL49_RS09015	COG4566	intracellular signal transduction
BTL49_RS09025	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
BTL49_RS09030	COG0508	dehydrogenase complex catalyzes the overall conversion of
BTL49_RS09035	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BTL49_RS09045	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BTL49_RS09050	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BTL49_RS09060	COG1028	Short-chain dehydrogenase reductase Sdr
BTL49_RS09065	COG0583	DNA-binding transcription factor activity
BTL49_RS09070	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BTL49_RS09095	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BTL49_RS09115	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BTL49_RS09130	COG2900	Belongs to the SlyX family
BTL49_RS09135	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BTL49_RS09160	COG2814	Major facilitator Superfamily
BTL49_RS09205	COG2801	Transposase and inactivated derivatives
BTL49_RS09260	COG2171	N-acyltransferase activity
BTL49_RS09265	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BTL49_RS09270	COG2890	protein-(glutamine-N5) methyltransferase activity
BTL49_RS09275	COG0488	(ABC) transporter
BTL49_RS09280	COG4771	TonB-dependent receptor
BTL49_RS09285	COG0210	DNA helicase
BTL49_RS09305	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BTL49_RS09340	COG2733	membrane
BTL49_RS09360	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
BTL49_RS09380	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BTL49_RS09385	COG1129	ABC transporter
BTL49_RS09385	COG0842	Transport permease protein
BTL49_RS09390	COG0842	Transport permease protein
BTL49_RS09400	COG1028	Short-chain dehydrogenase reductase Sdr
BTL49_RS09410	COG2259	Doxx family
BTL49_RS09440	COG0415	Belongs to the DNA photolyase family
BTL49_RS09460	COG0386	Belongs to the glutathione peroxidase family
BTL49_RS09475	COG0095	Lipoate-protein ligase
BTL49_RS09485	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BTL49_RS09495	COG0010	Belongs to the arginase family
BTL49_RS09505	COG0765	amino acid transport
BTL49_RS09510	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BTL49_RS09525	COG0084	hydrolase, TatD family'
BTL49_RS09535	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BTL49_RS09540	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BTL49_RS09550	COG2175	clavaminate synthase activity
BTL49_RS09555	COG0583	DNA-binding transcription factor activity
BTL49_RS09580	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
BTL49_RS09590	COG2914	Belongs to the UPF0125 (RnfH) family
BTL49_RS09600	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BTL49_RS09640	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BTL49_RS09640	COG0519	Catalyzes the synthesis of GMP from XMP
BTL49_RS09650	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
BTL49_RS09660	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BTL49_RS09665	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BTL49_RS09670	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BTL49_RS09680	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BTL49_RS09685	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BTL49_RS09695	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BTL49_RS09700	COG0750	zinc metalloprotease
BTL49_RS09705	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
BTL49_RS09715	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BTL49_RS09720	COG0233	cytoplasmic translational termination
BTL49_RS09725	COG0528	UMP kinase activity
BTL49_RS09730	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BTL49_RS09735	COG0052	Belongs to the universal ribosomal protein uS2 family
BTL49_RS09740	COG0024	Methionine aminopeptidase
BTL49_RS09745	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
BTL49_RS09765	COG1286	toxin biosynthetic process
BTL49_RS09775	COG0285	dihydrofolate synthase activity
BTL49_RS09785	COG3181	Tripartite tricarboxylate transporter family receptor
BTL49_RS09790	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BTL49_RS09830	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BTL49_RS09840	COG1677	Flagellar hook-basal body complex protein FliE
BTL49_RS09850	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BTL49_RS09855	COG1317	bacterial-type flagellum organization
BTL49_RS09875	COG1580	Controls the rotational direction of flagella during chemotaxis
BTL49_RS09885	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BTL49_RS09910	COG0840	transmembrane signaling receptor activity
BTL49_RS09915	COG0840	transmembrane signaling receptor activity
BTL49_RS09940	COG1191	sigma factor activity
BTL49_RS09980	COG2203	Gaf domain
BTL49_RS09980	COG2199	diguanylate cyclase activity
BTL49_RS09990	COG1619	proteins homologs of microcin C7 resistance protein MccF
BTL49_RS10015	COG1126	abc transporter atp-binding protein
BTL49_RS10020	COG0765	amino acid transport
BTL49_RS10025	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BTL49_RS10070	COG2200	EAL domain
BTL49_RS10090	COG1253	flavin adenine dinucleotide binding
BTL49_RS10095	COG5001	Diguanylate cyclase
BTL49_RS10095	COG4251	negative regulation of phosphorylation
BTL49_RS10095	COG3706	GGDEF domain
BTL49_RS10095	COG2203	Gaf domain
BTL49_RS10100	COG2197	response regulator
BTL49_RS10105	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BTL49_RS10105	COG2205	protein histidine kinase activity
BTL49_RS10130	COG0076	glutamate decarboxylase activity
BTL49_RS10135	COG2985	domain, Protein
BTL49_RS10140	COG3189	MarR family transcriptional regulator
BTL49_RS10150	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BTL49_RS10160	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BTL49_RS10160	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BTL49_RS10170	COG0028	Belongs to the TPP enzyme family
BTL49_RS10180	COG1012	belongs to the aldehyde dehydrogenase family
BTL49_RS10190	COG0688	phosphatidylethanolamine metabolic process
BTL49_RS10195	COG1304	FMN binding
BTL49_RS10200	COG1464	Belongs to the NlpA lipoprotein family
BTL49_RS10220	COG0697	spore germination
BTL49_RS10225	COG2133	pyrroloquinoline quinone binding
BTL49_RS10230	COG0625	glutathione transferase activity
BTL49_RS10245	COG1794	racemase activity, acting on amino acids and derivatives
BTL49_RS10265	COG0559	Belongs to the binding-protein-dependent transport system permease family
BTL49_RS10275	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BTL49_RS10290	COG1175	transmembrane transport
BTL49_RS10295	COG0395	ABC-type sugar transport system, permease component
BTL49_RS10300	COG3842	ATPase activity
BTL49_RS10325	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
BTL49_RS10340	COG0438	transferase activity, transferring glycosyl groups
BTL49_RS10365	COG0463	Glycosyl transferase, family 2
BTL49_RS10380	COG0783	Belongs to the Dps family
BTL49_RS10385	COG0583	DNA-binding transcription factor activity
BTL49_RS10390	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BTL49_RS10420	COG1840	ABC-type Fe3 transport system, periplasmic component
BTL49_RS10430	COG3842	ATPase activity
BTL49_RS10435	COG1741	Belongs to the pirin family
BTL49_RS10440	COG1741	Belongs to the pirin family
BTL49_RS10445	COG0583	DNA-binding transcription factor activity
BTL49_RS10460	COG0174	glutamine synthetase
BTL49_RS10465	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BTL49_RS10470	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BTL49_RS10480	COG0840	transmembrane signaling receptor activity
BTL49_RS10495	COG0583	DNA-binding transcription factor activity
BTL49_RS10500	COG1960	acyl-CoA dehydrogenase activity
BTL49_RS10505	COG2079	MmgE PrpD family protein
BTL49_RS10515	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
BTL49_RS10520	COG1561	YicC-like family, N-terminal region
BTL49_RS10530	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BTL49_RS10535	COG0791	NLP P60 protein
BTL49_RS10540	COG1028	Short-chain dehydrogenase reductase Sdr
BTL49_RS10545	COG0194	GDP metabolic process
BTL49_RS10550	COG1758	RNA polymerase activity
BTL49_RS10555	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BTL49_RS10560	COG1126	abc transporter atp-binding protein
BTL49_RS10565	COG0765	amino acid transport
BTL49_RS10570	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BTL49_RS10580	COG2831	hemolysin activation secretion protein
BTL49_RS10590	COG3188	usher protein
BTL49_RS10595	COG3121	Chaperone
BTL49_RS10615	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
BTL49_RS10615	COG3210	domain, Protein
BTL49_RS10615	COG3064	Membrane
BTL49_RS10615	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
BTL49_RS10615	COG3210	domain, Protein
BTL49_RS10615	COG3064	Membrane
BTL49_RS10625	COG4181	ATPase activity
BTL49_RS10635	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BTL49_RS10640	COG0584	glycerophosphoryl diester phosphodiesterase
BTL49_RS10645	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
BTL49_RS10655	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
BTL49_RS10655	COG0678	peroxiredoxin activity
BTL49_RS10665	COG2217	Heavy metal translocating P-type atpase
BTL49_RS10670	COG0789	Transcriptional regulator
BTL49_RS10675	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BTL49_RS10710	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BTL49_RS10720	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
BTL49_RS10745	COG0583	DNA-binding transcription factor activity
BTL49_RS10750	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BTL49_RS10755	COG2252	PERMEase
BTL49_RS10760	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BTL49_RS10765	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BTL49_RS10800	COG0488	(ABC) transporter
BTL49_RS10805	COG1619	proteins homologs of microcin C7 resistance protein MccF
BTL49_RS10810	COG0590	tRNA wobble adenosine to inosine editing
BTL49_RS10825	COG1320	monovalent cation:proton antiporter activity
BTL49_RS10830	COG2212	antiporter activity
BTL49_RS10835	COG1863	multisubunit Na H antiporter MnhE subunit
BTL49_RS10840	COG0651	ATP synthesis coupled electron transport
BTL49_RS10845	COG1006	Multisubunit Na H antiporter MnhC subunit
BTL49_RS10850	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BTL49_RS10850	COG2111	Na H antiporter
BTL49_RS10855	COG3181	Tripartite tricarboxylate transporter family receptor
BTL49_RS10880	COG0420	3'-5' exonuclease activity
BTL49_RS10915	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BTL49_RS10925	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
BTL49_RS10935	COG2130	NADP-dependent
BTL49_RS10940	COG1309	transcriptional regulator
BTL49_RS10950	COG1131	(ABC) transporter
BTL49_RS10955	COG0842	Transport permease protein
BTL49_RS10965	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BTL49_RS11000	COG0602	queuosine metabolic process
BTL49_RS11005	COG0720	synthase
BTL49_RS11040	COG0587	DNA-directed DNA polymerase activity
BTL49_RS11050	COG0390	transport system, permease component
BTL49_RS11055	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BTL49_RS11060	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
BTL49_RS11115	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BTL49_RS11140	COG5507	3-demethylubiquinone-9 3-methyltransferase
BTL49_RS11175	COG1396	sequence-specific DNA binding
BTL49_RS11200	COG0583	DNA-binding transcription factor activity
BTL49_RS11205	COG2814	Major facilitator Superfamily
BTL49_RS11230	COG2807	transmembrane transport
BTL49_RS11235	COG2207	Transcriptional regulator
BTL49_RS11240	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BTL49_RS11245	COG2814	Major facilitator Superfamily
BTL49_RS11260	COG1012	belongs to the aldehyde dehydrogenase family
BTL49_RS11295	COG0583	DNA-binding transcription factor activity
BTL49_RS11315	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BTL49_RS11340	COG0384	phenazine biosynthesis protein PhzF
BTL49_RS11345	COG1733	regulation of RNA biosynthetic process
BTL49_RS11380	COG3177	Filamentation induced by cAMP protein fic
BTL49_RS11390	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BTL49_RS11390	COG0519	Catalyzes the synthesis of GMP from XMP
BTL49_RS11405	COG1695	Transcriptional regulator
BTL49_RS11420	COG2072	flavoprotein involved in K transport
BTL49_RS11425	COG0601	transmembrane transport
BTL49_RS11445	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BTL49_RS11455	COG4608	Belongs to the ABC transporter superfamily
BTL49_RS11460	COG0747	negative chemotaxis
BTL49_RS11500	COG0047	phosphoribosylformylglycinamidine synthase activity
BTL49_RS11500	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BTL49_RS11505	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BTL49_RS11525	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BTL49_RS11525	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BTL49_RS11530	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BTL49_RS11540	COG0613	PHP domain protein
BTL49_RS11600	COG1012	belongs to the aldehyde dehydrogenase family
BTL49_RS11610	COG0583	DNA-binding transcription factor activity
BTL49_RS11630	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BTL49_RS11640	COG3181	Tripartite tricarboxylate transporter family receptor
BTL49_RS11650	COG3181	Tripartite tricarboxylate transporter family receptor
BTL49_RS11680	COG1595	DNA-templated transcription, initiation
BTL49_RS11685	COG3712	iron ion homeostasis
BTL49_RS11695	COG0084	hydrolase, TatD family'
BTL49_RS11700	COG1136	(ABC) transporter
BTL49_RS11715	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BTL49_RS11725	COG1028	Short-chain dehydrogenase reductase Sdr
BTL49_RS11730	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BTL49_RS11740	COG1803	Methylglyoxal synthase
BTL49_RS11760	COG2801	Transposase and inactivated derivatives
BTL49_RS11765	COG2801	Transposase and inactivated derivatives
BTL49_RS11790	COG2975	iron-sulfur cluster assembly
BTL49_RS11795	COG0633	Ferredoxin
BTL49_RS11800	COG0443	Heat shock 70 kDa protein
BTL49_RS11805	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
BTL49_RS11810	COG0316	Belongs to the HesB IscA family
BTL49_RS11815	COG0822	iron-sulfur transferase activity
BTL49_RS11820	COG1104	cysteine desulfurase activity
BTL49_RS11830	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BTL49_RS11835	COG0556	nucleotide-excision repair
BTL49_RS11850	COG0583	DNA-binding transcription factor activity
BTL49_RS11870	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BTL49_RS11910	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BTL49_RS11925	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BTL49_RS11935	COG0740	serine-type endopeptidase activity
BTL49_RS11940	COG0544	peptidyl-prolyl cis-trans isomerase activity
BTL49_RS11980	COG2801	Transposase and inactivated derivatives
BTL49_RS11990	COG1278	Cold shock
BTL49_RS12020	COG2433	Pfam Transposase IS66
BTL49_RS12080	COG1530	ribonuclease E activity
BTL49_RS12110	COG1846	Transcriptional regulator
BTL49_RS12120	COG1566	PFAM secretion protein HlyD family protein
BTL49_RS12125	COG2814	Major facilitator Superfamily
BTL49_RS12130	COG0473	3-isopropylmalate dehydrogenase activity
BTL49_RS12150	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BTL49_RS12155	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BTL49_RS12160	COG0433	COG0433 Predicted ATPase
BTL49_RS12165	COG0217	transcriptional regulatory protein
BTL49_RS12170	COG0151	Belongs to the GarS family
BTL49_RS12180	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BTL49_RS12185	COG0799	negative regulation of ribosome biogenesis
BTL49_RS12190	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BTL49_RS12195	COG0424	maF-like protein
BTL49_RS12205	COG4191	Histidine kinase
BTL49_RS12210	COG2204	response regulator
BTL49_RS12235	COG0500	methyltransferase
BTL49_RS12250	COG0803	Belongs to the bacterial solute-binding protein 9 family
BTL49_RS12255	COG1121	(ABC) transporter
BTL49_RS12260	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BTL49_RS12265	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BTL49_RS12295	COG4993	Dehydrogenase
BTL49_RS12305	COG4772	TonB-dependent receptor
BTL49_RS12310	COG2814	Major facilitator Superfamily
BTL49_RS12330	COG0037	tRNA processing
BTL49_RS12335	COG0825	malonyl-CoA metabolic process
BTL49_RS12345	COG0215	cysteine-tRNA ligase activity
BTL49_RS12355	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BTL49_RS12360	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BTL49_RS12365	COG1968	undecaprenyl-diphosphatase activity
BTL49_RS12370	COG1253	flavin adenine dinucleotide binding
BTL49_RS12375	COG0483	inositol monophosphate 1-phosphatase activity
BTL49_RS12395	COG0668	transmembrane transport
BTL49_RS12420	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BTL49_RS12430	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
BTL49_RS12445	COG1802	Transcriptional regulator
BTL49_RS12465	COG3360	Dodecin
BTL49_RS12485	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BTL49_RS12490	COG2850	peptidyl-arginine hydroxylation
BTL49_RS12500	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
BTL49_RS12505	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BTL49_RS12510	COG1994	Peptidase M50
BTL49_RS12515	COG0009	L-threonylcarbamoyladenylate synthase
BTL49_RS12520	COG2321	neutral zinc metallopeptidase
BTL49_RS12540	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BTL49_RS12550	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BTL49_RS12560	COG2271	Major facilitator Superfamily
BTL49_RS12635	COG2202	Pas domain
BTL49_RS12635	COG2200	EAL domain
BTL49_RS12635	COG2199	diguanylate cyclase activity
BTL49_RS12640	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
BTL49_RS12660	COG1960	acyl-CoA dehydrogenase activity
BTL49_RS12665	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BTL49_RS12670	COG2186	Transcriptional regulator
BTL49_RS12695	COG1595	DNA-templated transcription, initiation
BTL49_RS12730	COG1028	Short-chain dehydrogenase reductase Sdr
BTL49_RS12745	COG0179	Fumarylacetoacetate (FAA) hydrolase
BTL49_RS12765	COG4604	ABC transporter, ATP-binding protein
BTL49_RS12770	COG4605	iron ion homeostasis
BTL49_RS12775	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BTL49_RS12780	COG4607	ABC-type enterochelin transport system periplasmic component
BTL49_RS12785	COG0438	transferase activity, transferring glycosyl groups
BTL49_RS12795	COG0149	triose-phosphate isomerase activity
BTL49_RS12800	COG3321	synthase
BTL49_RS12800	COG4221	oxidoreductase activity
BTL49_RS12800	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BTL49_RS12800	COG0604	alcohol dehydrogenase
BTL49_RS12830	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BTL49_RS12830	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BTL49_RS12835	COG0668	transmembrane transport
BTL49_RS12840	COG0165	Argininosuccinate lyase
BTL49_RS12850	COG0789	Transcriptional regulator
BTL49_RS12860	COG0501	Belongs to the peptidase M48B family
BTL49_RS12865	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BTL49_RS12890	COG1024	Enoyl-CoA hydratase
BTL49_RS12895	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BTL49_RS12915	COG3468	outer membrane autotransporter barrel domain protein
BTL49_RS12955	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BTL49_RS12960	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BTL49_RS12965	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
BTL49_RS12970	COG1674	ftsk spoiiie
BTL49_RS12975	COG0492	ferredoxin-NADP+ reductase activity
BTL49_RS12980	COG1193	negative regulation of DNA recombination
BTL49_RS12995	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BTL49_RS13010	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
BTL49_RS13015	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
BTL49_RS13020	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
BTL49_RS13030	COG0745	RESPONSE REGULATOR receiver
BTL49_RS13065	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BTL49_RS13085	COG0612	Peptidase, M16
BTL49_RS13095	COG0443	Heat shock 70 kDa protein
BTL49_RS13105	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BTL49_RS13115	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
BTL49_RS13120	COG1420	regulation of RNA biosynthetic process
BTL49_RS13125	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BTL49_RS13130	COG0497	DNA recombination
BTL49_RS13160	COG0735	belongs to the Fur family
BTL49_RS13165	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BTL49_RS13210	COG2828	Protein conserved in bacteria
BTL49_RS13215	COG1280	lysine exporter protein (LysE YggA)
BTL49_RS13220	COG3181	Tripartite tricarboxylate transporter family receptor
BTL49_RS13235	COG1028	Short-chain dehydrogenase reductase Sdr
BTL49_RS13240	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
BTL49_RS13245	COG1802	Transcriptional regulator
BTL49_RS13250	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
BTL49_RS13255	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BTL49_RS13260	COG1335	isochorismatase
BTL49_RS13265	COG0523	cobalamin synthesis protein
BTL49_RS13295	COG0583	DNA-binding transcription factor activity
BTL49_RS13305	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
BTL49_RS13310	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
BTL49_RS13315	COG0167	dihydroorotate dehydrogenase activity
BTL49_RS13365	COG1414	Transcriptional regulator
BTL49_RS13385	COG0513	Belongs to the DEAD box helicase family
BTL49_RS13410	COG0429	hydrolase of the alpha beta-hydrolase fold
BTL49_RS13455	COG0006	proline dipeptidase activity
BTL49_RS13465	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BTL49_RS13490	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
BTL49_RS13495	COG0632	four-way junction helicase activity
BTL49_RS13510	COG2255	four-way junction helicase activity
BTL49_RS13515	COG0514	ATP-dependent DNA helicase (RecQ)
BTL49_RS13535	COG1294	oxidase, subunit
BTL49_RS13545	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BTL49_RS13550	COG0850	regulation of cytokinetic process
BTL49_RS13555	COG2894	cell division
BTL49_RS13560	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
BTL49_RS13585	COG0488	(ABC) transporter
BTL49_RS13600	COG4608	Belongs to the ABC transporter superfamily
BTL49_RS13605	COG0444	Belongs to the ABC transporter superfamily
BTL49_RS13610	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BTL49_RS13625	COG1215	transferase activity, transferring glycosyl groups
BTL49_RS13630	COG0583	DNA-binding transcription factor activity
BTL49_RS13635	COG1368	sulfuric ester hydrolase activity
BTL49_RS13640	COG1686	Belongs to the peptidase S11 family
BTL49_RS13650	COG1280	lysine exporter protein (LysE YggA)
BTL49_RS13660	COG1064	alcohol dehydrogenase
BTL49_RS13665	COG4191	Histidine kinase
BTL49_RS13670	COG4566	intracellular signal transduction
BTL49_RS13680	COG1802	Transcriptional regulator
BTL49_RS13705	COG3181	Tripartite tricarboxylate transporter family receptor
BTL49_RS13710	COG0513	Belongs to the DEAD box helicase family
BTL49_RS13715	COG0668	transmembrane transport
BTL49_RS13730	COG1595	DNA-templated transcription, initiation
BTL49_RS13770	COG0583	DNA-binding transcription factor activity
BTL49_RS13775	COG0531	amino acid
BTL49_RS13780	COG1982	Orn Lys Arg decarboxylase major
BTL49_RS13805	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BTL49_RS13810	COG0459	protein refolding
BTL49_RS13820	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
BTL49_RS13825	COG1252	NADH dehydrogenase
BTL49_RS13830	COG0284	orotidine-5'-phosphate decarboxylase activity
BTL49_RS13840	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BTL49_RS13850	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BTL49_RS13855	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BTL49_RS13885	COG1595	DNA-templated transcription, initiation
BTL49_RS13895	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
BTL49_RS13900	COG3639	organic phosphonate transmembrane transporter activity
BTL49_RS13905	COG3639	organic phosphonate transmembrane transporter activity
BTL49_RS13920	COG0742	ribosomal rna small subunit methyltransferase
BTL49_RS13925	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BTL49_RS13930	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
BTL49_RS13935	COG3135	benzoate transporter
BTL49_RS13955	COG4774	siderophore transport
BTL49_RS13980	COG1024	Enoyl-CoA hydratase
BTL49_RS13985	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BTL49_RS13990	COG1960	acyl-CoA dehydrogenase activity
BTL49_RS14000	COG0318	PFAM AMP-dependent synthetase and ligase
BTL49_RS14005	COG3181	Tripartite tricarboxylate transporter family receptor
BTL49_RS14015	COG0583	DNA-binding transcription factor activity
BTL49_RS14040	COG0277	FAD linked oxidase domain protein
BTL49_RS14060	COG1802	Transcriptional regulator
BTL49_RS14070	COG2271	Major facilitator Superfamily
BTL49_RS14080	COG0583	DNA-binding transcription factor activity
BTL49_RS14105	COG0012	GTP binding
BTL49_RS14115	COG0193	aminoacyl-tRNA hydrolase activity
BTL49_RS14120	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
BTL49_RS14125	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BTL49_RS14135	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BTL49_RS14150	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BTL49_RS14175	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
BTL49_RS14185	COG1368	sulfuric ester hydrolase activity
BTL49_RS14190	COG2186	Transcriptional regulator
BTL49_RS14200	COG3181	Tripartite tricarboxylate transporter family receptor
BTL49_RS14215	COG0277	FAD linked oxidase domain protein
BTL49_RS14230	COG0166	Belongs to the GPI family
BTL49_RS14235	COG0438	transferase activity, transferring glycosyl groups
BTL49_RS14240	COG0438	transferase activity, transferring glycosyl groups
BTL49_RS14255	COG0438	transferase activity, transferring glycosyl groups
BTL49_RS14270	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
BTL49_RS14275	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BTL49_RS14290	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
BTL49_RS14300	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BTL49_RS14310	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BTL49_RS14315	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BTL49_RS14330	COG0747	negative chemotaxis
BTL49_RS14340	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BTL49_RS14345	COG4172	Belongs to the ABC transporter superfamily
BTL49_RS14365	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BTL49_RS14365	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BTL49_RS14370	COG0509	glycine decarboxylation via glycine cleavage system
BTL49_RS14375	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BTL49_RS14380	COG2081	HI0933 family
BTL49_RS14395	COG0456	acetyltransferase
BTL49_RS14400	COG0717	Belongs to the dCTP deaminase family
BTL49_RS14415	COG0489	protein tyrosine kinase activity
BTL49_RS14425	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BTL49_RS14425	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BTL49_RS14450	COG3539	Fimbrial protein
BTL49_RS14465	COG0745	RESPONSE REGULATOR receiver
BTL49_RS14485	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BTL49_RS14490	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
BTL49_RS14505	COG2084	Dehydrogenase
BTL49_RS14510	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BTL49_RS14535	COG3842	ATPase activity
BTL49_RS14540	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
BTL49_RS14545	COG1960	acyl-CoA dehydrogenase activity
BTL49_RS14555	COG0583	DNA-binding transcription factor activity
BTL49_RS14565	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BTL49_RS14570	COG1024	Enoyl-CoA hydratase
BTL49_RS14585	COG0583	DNA-binding transcription factor activity
BTL49_RS14590	COG1408	metallophosphoesterase
BTL49_RS14595	COG0625	glutathione transferase activity
BTL49_RS14630	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BTL49_RS14630	COG0426	domain, Protein
BTL49_RS14635	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BTL49_RS14640	COG0583	DNA-binding transcription factor activity
BTL49_RS14650	COG1024	Enoyl-CoA hydratase
BTL49_RS14660	COG1960	acyl-CoA dehydrogenase activity
BTL49_RS14665	COG1028	Short-chain dehydrogenase reductase Sdr
BTL49_RS14670	COG1028	Short-chain dehydrogenase reductase Sdr
BTL49_RS14690	COG3181	Tripartite tricarboxylate transporter family receptor
BTL49_RS14695	COG1028	Short-chain dehydrogenase reductase Sdr
BTL49_RS14705	COG3181	Tripartite tricarboxylate transporter family receptor
BTL49_RS14745	COG0583	DNA-binding transcription factor activity
BTL49_RS14750	COG1960	acyl-CoA dehydrogenase activity
BTL49_RS14755	COG3181	Tripartite tricarboxylate transporter family receptor
BTL49_RS14760	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BTL49_RS14765	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BTL49_RS14790	COG0560	Phosphoserine phosphatase
BTL49_RS14795	COG0583	DNA-binding transcription factor activity
BTL49_RS14810	COG3842	ATPase activity
BTL49_RS14825	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BTL49_RS14845	COG0625	glutathione transferase activity
BTL49_RS14890	COG4336	lyase activity
BTL49_RS14900	COG0326	Molecular chaperone. Has ATPase activity
BTL49_RS14905	COG2233	PERMEase
BTL49_RS14945	COG2818	Glycosylase
BTL49_RS14950	COG0727	PFAM Uncharacterised protein family (UPF0153)
BTL49_RS14975	COG0402	S-adenosylhomocysteine deaminase activity
BTL49_RS14985	COG0156	8-amino-7-oxononanoate synthase activity
BTL49_RS14990	COG2877	3-deoxy-8-phosphooctulonate synthase activity
BTL49_RS15040	COG1464	Belongs to the NlpA lipoprotein family
BTL49_RS15045	COG2011	ABC-type metal ion transport system permease component
BTL49_RS15050	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BTL49_RS15055	COG1501	Belongs to the glycosyl hydrolase 31 family
BTL49_RS15060	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
BTL49_RS15060	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BTL49_RS15065	COG0483	inositol monophosphate 1-phosphatase activity
BTL49_RS15070	COG0318	PFAM AMP-dependent synthetase and ligase
BTL49_RS15075	COG1473	amidohydrolase
BTL49_RS15080	COG0583	DNA-binding transcription factor activity
BTL49_RS15085	COG2855	membrane
BTL49_RS15095	COG2239	Acts as a magnesium transporter
BTL49_RS15110	COG1522	sequence-specific DNA binding
BTL49_RS15150	COG0330	HflC and HflK could
BTL49_RS15155	COG0330	HflC and HflK could
BTL49_RS15160	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BTL49_RS15165	COG1923	regulation of RNA biosynthetic process
BTL49_RS15175	COG1160	GTP binding
BTL49_RS15180	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BTL49_RS15185	COG2976	Protein conserved in bacteria
BTL49_RS15190	COG0124	histidyl-tRNA synthetase
BTL49_RS15205	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BTL49_RS15210	COG0105	UTP biosynthetic process
BTL49_RS15215	COG0525	valine-tRNA ligase activity
BTL49_RS15225	COG0336	Belongs to the RNA methyltransferase TrmD family
BTL49_RS15230	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BTL49_RS15235	COG0228	four-way junction DNA binding
BTL49_RS15240	COG0425	Belongs to the sulfur carrier protein TusA family
BTL49_RS15245	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BTL49_RS15310	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BTL49_RS15315	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BTL49_RS15315	COG0543	2 iron, 2 sulfur cluster binding
BTL49_RS15320	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
BTL49_RS15325	COG2076	Multidrug Resistance protein
BTL49_RS15330	COG3217	Mosc domain protein beta barrel domain protein
BTL49_RS15330	COG0633	Ferredoxin
BTL49_RS15335	COG5285	phytanoyl-CoA dioxygenase
BTL49_RS15340	COG0662	Cupin 2, conserved barrel domain protein
BTL49_RS15350	COG0456	acetyltransferase
BTL49_RS15370	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BTL49_RS15400	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BTL49_RS15410	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
BTL49_RS15415	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BTL49_RS15420	COG1760	l-serine dehydratase
BTL49_RS15425	COG1283	sodium-dependent phosphate transmembrane transporter activity
BTL49_RS15430	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BTL49_RS15435	COG0412	Dienelactone hydrolase
BTL49_RS15440	COG0428	transporter
BTL49_RS15450	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BTL49_RS15455	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BTL49_RS15460	COG1845	cytochrome c oxidase, subunit III
BTL49_RS15465	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
BTL49_RS15475	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BTL49_RS15475	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BTL49_RS15500	COG1942	4-Oxalocrotonate Tautomerase
BTL49_RS15510	COG4176	ABC-type proline glycine betaine transport system permease component
BTL49_RS15530	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BTL49_RS15535	COG2814	Major facilitator Superfamily
BTL49_RS15540	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BTL49_RS15545	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BTL49_RS15570	COG1846	Transcriptional regulator
BTL49_RS15575	COG2814	Major facilitator Superfamily
BTL49_RS15580	COG0495	leucyl-tRNA aminoacylation
BTL49_RS15595	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BTL49_RS15615	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BTL49_RS15620	COG2274	protein secretion by the type I secretion system
BTL49_RS15665	COG0427	acetyl-CoA hydrolase
BTL49_RS15675	COG3264	Mechanosensitive ion channel
BTL49_RS15675	COG1511	domain protein
BTL49_RS15680	COG0730	response to heat
BTL49_RS15695	COG2176	DNA-directed DNA polymerase activity
BTL49_RS15715	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
BTL49_RS15720	COG3384	dioxygenase
BTL49_RS15735	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BTL49_RS15805	COG4964	Belongs to the GSP D family
BTL49_RS15850	COG1846	Transcriptional regulator
BTL49_RS15885	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
BTL49_RS15895	COG2070	2-Nitropropane dioxygenase
BTL49_RS15900	COG2070	2-Nitropropane dioxygenase
BTL49_RS15910	COG2610	gluconate transmembrane transporter activity
BTL49_RS15925	COG1408	metallophosphoesterase
BTL49_RS15930	COG0493	'glutamate synthase
BTL49_RS15930	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
BTL49_RS15935	COG2199	diguanylate cyclase activity
BTL49_RS15940	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
BTL49_RS15975	COG2159	amidohydrolase
BTL49_RS15985	COG0583	DNA-binding transcription factor activity
BTL49_RS16000	COG1024	Enoyl-CoA hydratase
BTL49_RS16005	COG2186	Transcriptional regulator
BTL49_RS16010	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BTL49_RS16020	COG0833	amino acid
BTL49_RS16030	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
BTL49_RS16065	COG5265	(ABC) transporter
BTL49_RS16105	COG1971	Probably functions as a manganese efflux pump
BTL49_RS16110	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BTL49_RS16120	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BTL49_RS16125	COG2814	Major facilitator Superfamily
BTL49_RS16150	COG4608	Belongs to the ABC transporter superfamily
BTL49_RS16170	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BTL49_RS16180	COG3383	formate dehydrogenase (NAD+) activity
BTL49_RS16195	COG0747	negative chemotaxis
BTL49_RS16205	COG0625	glutathione transferase activity
BTL49_RS16235	COG1595	DNA-templated transcription, initiation
BTL49_RS16245	COG4774	siderophore transport
BTL49_RS16260	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BTL49_RS16275	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
BTL49_RS16280	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
BTL49_RS16305	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BTL49_RS16310	COG1024	Enoyl-CoA hydratase
BTL49_RS16345	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BTL49_RS16350	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BTL49_RS16355	COG1116	anion transmembrane transporter activity
BTL49_RS16360	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BTL49_RS16365	COG3585	molybdate ion transport
BTL49_RS16425	COG0583	DNA-binding transcription factor activity
BTL49_RS16430	COG4948	Mandelate Racemase Muconate Lactonizing
BTL49_RS16435	COG3181	Tripartite tricarboxylate transporter family receptor
BTL49_RS16460	COG3181	Tripartite tricarboxylate transporter family receptor
BTL49_RS16465	COG3181	Tripartite tricarboxylate transporter family receptor
BTL49_RS16500	COG4177	L-phenylalanine transmembrane transporter activity
BTL49_RS16525	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BTL49_RS16540	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BTL49_RS16545	COG1538	Outer membrane efflux protein
BTL49_RS16550	COG1136	(ABC) transporter
BTL49_RS16550	COG0577	efflux transmembrane transporter activity
BTL49_RS16555	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BTL49_RS16570	COG0259	pyridoxamine-phosphate oxidase activity
BTL49_RS16575	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BTL49_RS16580	COG0579	oxidoreductase
BTL49_RS16590	COG0405	Gamma-glutamyltransferase
BTL49_RS16600	COG3181	Tripartite tricarboxylate transporter family receptor
BTL49_RS16610	COG0114	fumarate hydratase activity
BTL49_RS16615	COG0802	atpase or kinase
BTL49_RS16620	COG0860	N-Acetylmuramoyl-L-alanine amidase
BTL49_RS16625	COG0586	Pfam SNARE associated Golgi protein
BTL49_RS16630	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BTL49_RS16635	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BTL49_RS16640	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BTL49_RS16655	COG0617	tRNA 3'-terminal CCA addition
BTL49_RS16690	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
BTL49_RS16700	COG1024	Enoyl-CoA hydratase
BTL49_RS16710	COG2188	Transcriptional regulator
BTL49_RS16715	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BTL49_RS16730	COG0752	glycyl-tRNA synthetase alpha subunit
BTL49_RS16735	COG0751	glycine-tRNA ligase activity
BTL49_RS16740	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
BTL49_RS16745	COG0204	Acyl-transferase
BTL49_RS16775	COG0242	peptide deformylase activity
BTL49_RS16785	COG0700	Nucleoside recognition
BTL49_RS16790	COG0469	pyruvate kinase activity
BTL49_RS16795	COG1929	Belongs to the glycerate kinase type-1 family
BTL49_RS16805	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BTL49_RS16810	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BTL49_RS16815	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
BTL49_RS16825	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
BTL49_RS16835	COG2154	pterin-4-alpha-carbinolamine dehydratase
BTL49_RS16840	COG2885	chlorophyll binding
BTL49_RS16850	COG0667	Aldo Keto reductase
BTL49_RS16860	COG3181	Tripartite tricarboxylate transporter family receptor
BTL49_RS16880	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BTL49_RS16885	COG0288	reversible hydration of carbon dioxide
BTL49_RS16905	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BTL49_RS16915	COG4829	muconolactone delta-isomerase
BTL49_RS16920	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
BTL49_RS16930	COG1414	Transcriptional regulator
BTL49_RS16935	COG1028	Short-chain dehydrogenase reductase Sdr
BTL49_RS16940	COG2031	fatty acid transporter
BTL49_RS16945	COG1250	3-hydroxyacyl-CoA dehydrogenase
BTL49_RS16955	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
BTL49_RS16960	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
BTL49_RS16975	COG0129	dihydroxy-acid dehydratase activity
BTL49_RS16980	COG1609	Transcriptional regulator
BTL49_RS17000	COG4106	trans-aconitate 2-methyltransferase activity
BTL49_RS17020	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BTL49_RS17060	COG0163	prenyltransferase activity
BTL49_RS17065	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BTL49_RS17070	COG2890	protein-(glutamine-N5) methyltransferase activity
BTL49_RS17075	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BTL49_RS17080	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
BTL49_RS17095	COG3712	iron ion homeostasis
BTL49_RS17125	COG0659	secondary active sulfate transmembrane transporter activity
BTL49_RS17145	COG1028	Short-chain dehydrogenase reductase Sdr
BTL49_RS17160	COG4774	siderophore transport
BTL49_RS17170	COG1595	DNA-templated transcription, initiation
BTL49_RS17185	COG0142	geranyltranstransferase activity
BTL49_RS17190	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BTL49_RS17195	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BTL49_RS17200	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BTL49_RS17205	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BTL49_RS17225	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BTL49_RS17225	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BTL49_RS17230	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
BTL49_RS17245	COG0583	DNA-binding transcription factor activity
BTL49_RS17250	COG0861	Integral membrane protein TerC family
BTL49_RS17265	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BTL49_RS17270	COG0793	Belongs to the peptidase S41A family
BTL49_RS17275	COG4942	peptidase
BTL49_RS17280	COG0588	phosphoglycerate mutase activity
BTL49_RS17290	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
BTL49_RS17295	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
BTL49_RS17300	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BTL49_RS17305	COG3181	Tripartite tricarboxylate transporter family receptor
BTL49_RS17320	COG2226	methyltransferase
BTL49_RS17325	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
BTL49_RS17330	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BTL49_RS17340	COG2204	response regulator
BTL49_RS17345	COG5000	phosphorelay sensor kinase activity
BTL49_RS17355	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BTL49_RS17355	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BTL49_RS17395	COG2188	Transcriptional regulator
BTL49_RS17410	COG0583	DNA-binding transcription factor activity
BTL49_RS17415	COG1012	belongs to the aldehyde dehydrogenase family
BTL49_RS17435	COG0546	phosphoglycolate phosphatase activity
BTL49_RS17450	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BTL49_RS17455	COG0242	peptide deformylase activity
BTL49_RS17465	COG1522	sequence-specific DNA binding
BTL49_RS17470	COG2879	small protein
BTL49_RS17475	COG1966	Carbon starvation protein
BTL49_RS17505	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BTL49_RS17510	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BTL49_RS17515	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BTL49_RS17520	COG3181	Tripartite tricarboxylate transporter family receptor
BTL49_RS17585	COG1172	Belongs to the binding-protein-dependent transport system permease family
BTL49_RS17620	COG0640	Transcriptional regulator
BTL49_RS17660	COG0735	belongs to the Fur family
BTL49_RS17665	COG2207	Transcriptional regulator
BTL49_RS17670	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BTL49_RS17675	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BTL49_RS17680	COG0513	Belongs to the DEAD box helicase family
BTL49_RS17710	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BTL49_RS17725	COG1305	Transglutaminase-like
BTL49_RS17765	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BTL49_RS17770	COG1950	PFAM Membrane protein of
BTL49_RS17795	COG0024	Methionine aminopeptidase
BTL49_RS17800	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BTL49_RS17810	COG1560	Kdo2-lipid A biosynthetic process
BTL49_RS17815	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BTL49_RS17825	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
BTL49_RS17860	COG0735	belongs to the Fur family
BTL49_RS17865	COG0523	cobalamin synthesis protein
BTL49_RS17880	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
BTL49_RS17890	COG2096	Adenosyltransferase
BTL49_RS17895	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BTL49_RS17900	COG0321	lipoyl(octanoyl) transferase activity
BTL49_RS17910	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BTL49_RS17915	COG1686	Belongs to the peptidase S11 family
BTL49_RS17940	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BTL49_RS17950	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
BTL49_RS17960	COG0859	PFAM glycosyl transferase family 9
BTL49_RS17995	COG0477	Major facilitator Superfamily
BTL49_RS18010	COG3568	Endonuclease Exonuclease Phosphatase
BTL49_RS18015	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BTL49_RS18045	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BTL49_RS18050	COG1956	GAF domain-containing protein
BTL49_RS18055	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BTL49_RS18070	COG2186	Transcriptional regulator
BTL49_RS18075	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
BTL49_RS18090	COG1840	ABC-type Fe3 transport system, periplasmic component
BTL49_RS18130	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BTL49_RS18135	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BTL49_RS18140	COG1086	Polysaccharide biosynthesis protein
BTL49_RS18175	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
BTL49_RS18185	COG1028	Short-chain dehydrogenase reductase Sdr
BTL49_RS18190	COG1012	belongs to the aldehyde dehydrogenase family
BTL49_RS18215	COG1522	sequence-specific DNA binding
BTL49_RS18220	COG3781	membrane
BTL49_RS18260	COG2200	EAL domain
BTL49_RS18270	COG0592	DNA-directed DNA polymerase activity
BTL49_RS18275	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BTL49_RS18280	COG0230	Belongs to the bacterial ribosomal protein bL34 family
BTL49_RS18285	COG0594	ribonuclease P activity
BTL49_RS18290	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
BTL49_RS18295	COG0706	membrane insertase activity
BTL49_RS18300	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
BTL49_RS18305	COG1473	amidohydrolase
BTL49_RS18310	COG4608	Belongs to the ABC transporter superfamily
BTL49_RS18315	COG0444	Belongs to the ABC transporter superfamily
BTL49_RS18320	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BTL49_RS18325	COG0601	transmembrane transport
BTL49_RS18335	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BTL49_RS18340	COG1505	serine-type exopeptidase activity
BTL49_RS18350	COG0281	malic enzyme
BTL49_RS18350	COG0280	phosphate acetyltransferase
BTL49_RS18380	COG0436	Aminotransferase
BTL49_RS18385	COG1278	Cold shock