locus-tag	class	description
BTL50_RS00005	COG0445	tRNA wobble uridine modification
BTL50_RS00010	COG0357	Ribosomal RNA small subunit methyltransferase G
BTL50_RS00015	COG1192	Involved in chromosome partitioning
BTL50_RS00020	COG1475	DNA binding
BTL50_RS00025	COG0252	asparaginase activity
BTL50_RS00045	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BTL50_RS00055	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BTL50_RS00065	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BTL50_RS00070	COG0081	regulation of translation
BTL50_RS00075	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BTL50_RS00080	COG0222	ribosome binding
BTL50_RS00085	COG0085	RNA polymerase activity
BTL50_RS00090	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BTL50_RS00125	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BTL50_RS00130	COG0049	tRNA binding
BTL50_RS00135	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BTL50_RS00140	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BTL50_RS00145	COG0051	transcription antitermination factor activity, RNA binding
BTL50_RS00150	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BTL50_RS00155	COG0088	Forms part of the polypeptide exit tunnel
BTL50_RS00160	COG0089	rRNA binding
BTL50_RS00165	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BTL50_RS00170	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BTL50_RS00175	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BTL50_RS00180	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BTL50_RS00185	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BTL50_RS00190	COG0255	Belongs to the universal ribosomal protein uL29 family
BTL50_RS00195	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BTL50_RS00205	COG4177	L-phenylalanine transmembrane transporter activity
BTL50_RS00215	COG1129	ABC transporter
BTL50_RS00220	COG0411	ABC transporter
BTL50_RS00250	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BTL50_RS00255	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BTL50_RS00260	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BTL50_RS00265	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BTL50_RS00270	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BTL50_RS00275	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BTL50_RS00280	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BTL50_RS00285	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BTL50_RS00290	COG1841	ribosomal large subunit assembly
BTL50_RS00295	COG0200	Binds to the 23S rRNA
BTL50_RS00300	COG0201	protein transport
BTL50_RS00305	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BTL50_RS00310	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BTL50_RS00315	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BTL50_RS00320	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BTL50_RS00325	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BTL50_RS00330	COG0202	RNA polymerase activity
BTL50_RS00335	COG0203	ribosomal protein L17
BTL50_RS00340	COG0537	adenosine 5'-monophosphoramidase activity
BTL50_RS00345	COG1324	tolerance protein
BTL50_RS00350	COG4232	protein-disulfide reductase activity
BTL50_RS00365	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BTL50_RS00375	COG1333	cytochrome c biogenesis protein
BTL50_RS00380	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BTL50_RS00395	COG1965	Belongs to the frataxin family
BTL50_RS00405	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BTL50_RS00410	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BTL50_RS00415	COG0232	Belongs to the dGTPase family. Type 2 subfamily
BTL50_RS00435	COG2814	Major facilitator Superfamily
BTL50_RS00480	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BTL50_RS00485	COG2922	Belongs to the Smg family
BTL50_RS00490	COG1629	transport
BTL50_RS00500	COG2358	TRAP transporter, solute receptor (TAXI family
BTL50_RS00510	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BTL50_RS00525	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BTL50_RS00530	COG0183	Belongs to the thiolase family
BTL50_RS00535	COG1960	acyl-CoA dehydrogenase activity
BTL50_RS00560	COG2200	EAL domain
BTL50_RS00565	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BTL50_RS00575	COG0018	arginyl-trna synthetase
BTL50_RS00590	COG0154	amidase activity
BTL50_RS00595	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BTL50_RS00605	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
BTL50_RS00615	COG0697	spore germination
BTL50_RS00675	COG3350	monooxygenase activity
BTL50_RS00700	COG1309	transcriptional regulator
BTL50_RS00730	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
BTL50_RS00735	COG1280	lysine exporter protein (LysE YggA)
BTL50_RS00740	COG0513	Belongs to the DEAD box helicase family
BTL50_RS00750	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
BTL50_RS00755	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BTL50_RS00785	COG2969	positive regulation of protein catabolic process
BTL50_RS00790	COG0625	glutathione transferase activity
BTL50_RS00795	COG2857	Cytochrome c1
BTL50_RS00800	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BTL50_RS00805	COG0723	plastoquinol--plastocyanin reductase activity
BTL50_RS00810	COG1970	mechanosensitive ion channel activity
BTL50_RS00815	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BTL50_RS00820	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BTL50_RS00830	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BTL50_RS00835	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BTL50_RS00845	COG0140	phosphoribosyl-ATP diphosphatase activity
BTL50_RS00850	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BTL50_RS00855	COG0107	imidazoleglycerol-phosphate synthase activity
BTL50_RS00860	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BTL50_RS00870	COG0131	Imidazoleglycerol-phosphate dehydratase
BTL50_RS00875	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BTL50_RS00880	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
BTL50_RS00885	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BTL50_RS00890	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BTL50_RS00900	COG0842	Transport permease protein
BTL50_RS00905	COG1131	(ABC) transporter
BTL50_RS00920	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BTL50_RS00925	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BTL50_RS00930	COG1127	ABC transporter
BTL50_RS00950	COG0067	glutamate synthase
BTL50_RS00950	COG0070	glutamate synthase
BTL50_RS00950	COG0069	glutamate synthase activity
BTL50_RS00975	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
BTL50_RS01000	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BTL50_RS01005	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
BTL50_RS01045	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BTL50_RS01080	COG0109	protoheme IX farnesyltransferase activity
BTL50_RS01085	COG1999	signal sequence binding
BTL50_RS01105	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BTL50_RS01110	COG2814	Major facilitator Superfamily
BTL50_RS01125	COG1522	sequence-specific DNA binding
BTL50_RS01185	COG4948	Mandelate Racemase Muconate Lactonizing
BTL50_RS01200	COG3119	arylsulfatase activity
BTL50_RS01240	COG0402	S-adenosylhomocysteine deaminase activity
BTL50_RS01250	COG1304	FMN binding
BTL50_RS01255	COG1254	Belongs to the acylphosphatase family
BTL50_RS01265	COG3181	Tripartite tricarboxylate transporter family receptor
BTL50_RS01275	COG1414	Transcriptional regulator
BTL50_RS01295	COG0028	Belongs to the TPP enzyme family
BTL50_RS01300	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
BTL50_RS01305	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BTL50_RS01310	COG1960	acyl-CoA dehydrogenase activity
BTL50_RS01345	COG3181	Tripartite tricarboxylate transporter family receptor
BTL50_RS01350	COG0583	DNA-binding transcription factor activity
BTL50_RS01365	COG0129	dihydroxy-acid dehydratase activity
BTL50_RS01370	COG2084	Dehydrogenase
BTL50_RS01385	COG1671	Belongs to the UPF0178 family
BTL50_RS01390	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
BTL50_RS01405	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
BTL50_RS01410	COG0443	Heat shock 70 kDa protein
BTL50_RS01435	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BTL50_RS01435	COG2169	Transcriptional regulator
BTL50_RS01450	COG1683	Conserved Protein
BTL50_RS01455	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BTL50_RS01470	COG1120	ATPase activity
BTL50_RS01475	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BTL50_RS01480	COG4558	Periplasmic binding protein
BTL50_RS01485	COG3720	iron ion transport
BTL50_RS01495	COG3712	iron ion homeostasis
BTL50_RS01500	COG1595	DNA-templated transcription, initiation
BTL50_RS01520	COG1607	acyl-coa hydrolase
BTL50_RS01530	COG0243	molybdopterin cofactor binding
BTL50_RS01530	COG3383	formate dehydrogenase (NAD+) activity
BTL50_RS01535	COG0243	molybdopterin cofactor binding
BTL50_RS01535	COG3383	formate dehydrogenase (NAD+) activity
BTL50_RS01540	COG0437	4 iron, 4 sulfur cluster binding
BTL50_RS01545	COG2864	formate dehydrogenase
BTL50_RS01560	COG3276	selenocysteine insertion sequence binding
BTL50_RS01595	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BTL50_RS01600	COG0512	Glutamine amidotransferase of anthranilate synthase
BTL50_RS01610	COG0546	phosphoglycolate phosphatase activity
BTL50_RS01615	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BTL50_RS01620	COG2967	ApaG domain
BTL50_RS01625	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
BTL50_RS01630	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BTL50_RS01635	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BTL50_RS01640	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BTL50_RS01645	COG0037	tRNA processing
BTL50_RS01665	COG1024	Enoyl-CoA hydratase
BTL50_RS01680	COG0356	it plays a direct role in the translocation of protons across the membrane
BTL50_RS01690	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BTL50_RS01695	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BTL50_RS01700	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BTL50_RS01705	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BTL50_RS01710	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BTL50_RS01715	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BTL50_RS01740	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
BTL50_RS01745	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BTL50_RS01750	COG0210	DNA helicase
BTL50_RS01765	COG4608	Belongs to the ABC transporter superfamily
BTL50_RS01770	COG0444	Belongs to the ABC transporter superfamily
BTL50_RS01775	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BTL50_RS01800	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BTL50_RS01805	COG1024	Enoyl-CoA hydratase
BTL50_RS01810	COG1024	Enoyl-CoA hydratase
BTL50_RS01815	COG2070	2-Nitropropane dioxygenase
BTL50_RS01830	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BTL50_RS01835	COG1250	3-hydroxyacyl-CoA dehydrogenase
BTL50_RS01855	COG2267	carboxylic ester hydrolase activity
BTL50_RS01875	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
BTL50_RS01885	COG2813	Specifically methylates the guanine in position
BTL50_RS01885	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BTL50_RS01890	COG2223	nitrite transmembrane transporter activity
BTL50_RS01895	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
BTL50_RS01910	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BTL50_RS01915	COG0708	Exodeoxyribonuclease III
BTL50_RS01920	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BTL50_RS01925	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BTL50_RS01930	COG0154	amidase activity
BTL50_RS01935	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BTL50_RS01940	COG1077	Cell shape determining protein MreB Mrl
BTL50_RS01945	COG1792	Involved in formation and maintenance of cell shape
BTL50_RS01955	COG0768	penicillin binding
BTL50_RS01960	COG0772	Belongs to the SEDS family
BTL50_RS01965	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
BTL50_RS01970	COG0471	metal ion transport
BTL50_RS01975	COG1309	transcriptional regulator
BTL50_RS01985	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BTL50_RS02000	COG2823	Periplasmic or secreted lipoprotein
BTL50_RS02005	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
BTL50_RS02010	COG0792	nuclease activity
BTL50_RS02030	COG1660	Displays ATPase and GTPase activities
BTL50_RS02045	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
BTL50_RS02055	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
BTL50_RS02065	COG3181	Tripartite tricarboxylate transporter family receptor
BTL50_RS02070	COG1473	amidohydrolase
BTL50_RS02075	COG1137	ATPase activity
BTL50_RS02090	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
BTL50_RS02100	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
BTL50_RS02120	COG1294	oxidase, subunit
BTL50_RS02130	COG4988	ABC transporter
BTL50_RS02135	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BTL50_RS02140	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BTL50_RS02155	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BTL50_RS02160	COG1238	metal cluster binding
BTL50_RS02180	COG1984	allophanate hydrolase subunit 2
BTL50_RS02185	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
BTL50_RS02195	COG0583	DNA-binding transcription factor activity
BTL50_RS02200	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BTL50_RS02205	COG5002	protein histidine kinase activity
BTL50_RS02210	COG0745	RESPONSE REGULATOR receiver
BTL50_RS02215	COG2226	methyltransferase
BTL50_RS02260	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BTL50_RS02270	COG1028	Short-chain dehydrogenase reductase Sdr
BTL50_RS02290	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BTL50_RS02295	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BTL50_RS02305	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BTL50_RS02325	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
BTL50_RS02330	COG1538	Outer membrane efflux protein
BTL50_RS02340	COG0351	phosphomethylpyrimidine kinase
BTL50_RS02345	COG2022	thiamine diphosphate biosynthetic process
BTL50_RS02350	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BTL50_RS02370	COG2226	methyltransferase
BTL50_RS02380	COG1194	a g-specific adenine glycosylase
BTL50_RS02390	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
BTL50_RS02395	COG2177	Part of the ABC transporter FtsEX involved in
BTL50_RS02400	COG2884	Cell division ATP-binding protein ftsE
BTL50_RS02405	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BTL50_RS02410	COG4597	amino acid ABC transporter
BTL50_RS02415	COG0765	amino acid transport
BTL50_RS02420	COG1126	abc transporter atp-binding protein
BTL50_RS02450	COG0477	Major facilitator Superfamily
BTL50_RS02460	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
BTL50_RS02465	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
BTL50_RS02480	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
BTL50_RS02485	COG0237	dephospho-CoA kinase activity
BTL50_RS02490	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
BTL50_RS02500	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BTL50_RS02515	COG3539	Fimbrial protein
BTL50_RS02520	COG3539	Fimbrial protein
BTL50_RS02535	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
BTL50_RS02545	COG1846	Transcriptional regulator
BTL50_RS02610	COG1028	Short-chain dehydrogenase reductase Sdr
BTL50_RS02615	COG1024	Enoyl-CoA hydratase
BTL50_RS02620	COG1960	acyl-CoA dehydrogenase activity
BTL50_RS02650	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BTL50_RS02655	COG0352	thiamine-phosphate diphosphorylase activity
BTL50_RS02660	COG0351	phosphomethylpyrimidine kinase
BTL50_RS02670	COG1678	Uncharacterized ACR, COG1678
BTL50_RS02675	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BTL50_RS02700	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BTL50_RS02710	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BTL50_RS02715	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BTL50_RS02725	COG0557	exoribonuclease II activity
BTL50_RS02735	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BTL50_RS02740	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BTL50_RS02745	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BTL50_RS02755	COG0439	Biotin carboxylase
BTL50_RS02760	COG2264	protein methyltransferase activity
BTL50_RS02770	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BTL50_RS02795	COG1696	Membrane protein involved in D-alanine export
BTL50_RS02800	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BTL50_RS02840	COG1522	sequence-specific DNA binding
BTL50_RS02855	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BTL50_RS02920	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BTL50_RS02945	COG3028	Belongs to the UPF0307 family
BTL50_RS02950	COG0312	modulator of DNA gyrase
BTL50_RS02955	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BTL50_RS02960	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BTL50_RS02965	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
BTL50_RS02975	COG0316	Belongs to the HesB IscA family
BTL50_RS02985	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
BTL50_RS02995	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BTL50_RS03000	COG1881	PFAM PEBP family protein
BTL50_RS03005	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BTL50_RS03010	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BTL50_RS03025	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BTL50_RS03025	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BTL50_RS03040	COG2718	Belongs to the UPF0229 family
BTL50_RS03045	COG2719	SpoVR family
BTL50_RS03110	COG0165	Argininosuccinate lyase
BTL50_RS03115	COG0589	response to stress
BTL50_RS03125	COG2816	NAD+ diphosphatase activity
BTL50_RS03130	COG4993	Dehydrogenase
BTL50_RS03155	COG3181	Tripartite tricarboxylate transporter family receptor
BTL50_RS03160	COG2979	Protein of unknown function (DUF533)
BTL50_RS03165	COG4206	TonB-dependent receptor
BTL50_RS03180	COG1388	LysM domain
BTL50_RS03180	COG0741	lytic transglycosylase activity
BTL50_RS03185	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BTL50_RS03190	COG2226	methyltransferase
BTL50_RS03195	COG0328	RNA-DNA hybrid ribonuclease activity
BTL50_RS03220	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BTL50_RS03240	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BTL50_RS03245	COG0842	Transport permease protein
BTL50_RS03245	COG1129	ABC transporter
BTL50_RS03250	COG0842	Transport permease protein
BTL50_RS03270	COG0463	Glycosyl transferase, family 2
BTL50_RS03275	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
BTL50_RS03290	COG1073	alpha beta
BTL50_RS03300	COG0697	spore germination
BTL50_RS03305	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BTL50_RS03330	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BTL50_RS03360	COG0823	Involved in the tonB-independent uptake of proteins
BTL50_RS03370	COG0848	biopolymer transport protein
BTL50_RS03375	COG0811	peptide transport
BTL50_RS03380	COG0824	Thioesterase
BTL50_RS03385	COG0442	prolyl-tRNA aminoacylation
BTL50_RS03430	COG2084	Dehydrogenase
BTL50_RS03475	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BTL50_RS03480	COG4654	Cytochrome c, class I
BTL50_RS03485	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BTL50_RS03550	COG1473	amidohydrolase
BTL50_RS03555	COG0418	dihydroorotase activity
BTL50_RS03560	COG0488	(ABC) transporter
BTL50_RS03570	COG2001	Belongs to the MraZ family
BTL50_RS03575	COG0275	rRNA processing
BTL50_RS03580	COG3116	cell division
BTL50_RS03590	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BTL50_RS03595	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BTL50_RS03600	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BTL50_RS03610	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BTL50_RS03615	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BTL50_RS03620	COG1181	Belongs to the D-alanine--D-alanine ligase family
BTL50_RS03625	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BTL50_RS03640	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
BTL50_RS03655	COG0739	heme binding
BTL50_RS03660	COG0653	protein targeting
BTL50_RS03685	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
BTL50_RS03690	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BTL50_RS03700	COG0828	Belongs to the bacterial ribosomal protein bS21 family
BTL50_RS03740	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
BTL50_RS03755	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
BTL50_RS03780	COG0583	DNA-binding transcription factor activity
BTL50_RS03790	COG3181	Tripartite tricarboxylate transporter family receptor
BTL50_RS03795	COG2084	Dehydrogenase
BTL50_RS03805	COG1597	lipid kinase activity
BTL50_RS03805	COG1803	Methylglyoxal synthase
BTL50_RS03815	COG0671	phosphoesterase, PA-phosphatase related
BTL50_RS03835	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
BTL50_RS03840	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BTL50_RS03845	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BTL50_RS03850	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BTL50_RS03855	COG0649	NAD binding
BTL50_RS03860	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
BTL50_RS03870	COG1034	ATP synthesis coupled electron transport
BTL50_RS03875	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
BTL50_RS03880	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BTL50_RS03890	COG0713	ATP synthesis coupled electron transport
BTL50_RS03905	COG1007	ATP synthesis coupled electron transport
BTL50_RS03915	COG0560	Phosphoserine phosphatase
BTL50_RS03920	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BTL50_RS03925	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
BTL50_RS03930	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BTL50_RS03945	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BTL50_RS03950	COG0450	alkyl hydroperoxide reductase
BTL50_RS03970	COG1214	PFAM Peptidase M22, glycoprotease
BTL50_RS03975	COG1573	uracil-dna glycosylase
BTL50_RS03980	COG0477	Major facilitator Superfamily
BTL50_RS03985	COG1196	nuclear chromosome segregation
BTL50_RS03995	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BTL50_RS04000	COG1126	abc transporter atp-binding protein
BTL50_RS04005	COG0765	amino acid transport
BTL50_RS04010	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BTL50_RS04015	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BTL50_RS04020	COG2917	probably involved in intracellular septation
BTL50_RS04025	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BTL50_RS04030	COG1122	ATPase activity
BTL50_RS04035	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
BTL50_RS04070	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BTL50_RS04095	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BTL50_RS04100	COG2878	Part of a membrane complex involved in electron transport
BTL50_RS04120	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
BTL50_RS04125	COG0251	oxidation-reduction process
BTL50_RS04135	COG3228	Belongs to the MtfA family
BTL50_RS04140	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BTL50_RS04150	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BTL50_RS04160	COG0159	tryptophan synthase activity
BTL50_RS04165	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
BTL50_RS04170	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
BTL50_RS04185	COG1530	ribonuclease E activity
BTL50_RS04190	COG0564	pseudouridine synthase activity
BTL50_RS04195	COG0546	phosphoglycolate phosphatase activity
BTL50_RS04200	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BTL50_RS04205	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
BTL50_RS04210	COG3023	N-Acetylmuramoyl-L-alanine amidase
BTL50_RS04220	COG0424	maF-like protein
BTL50_RS04230	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BTL50_RS04240	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BTL50_RS04250	COG1028	Short-chain dehydrogenase reductase Sdr
BTL50_RS04255	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BTL50_RS04260	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BTL50_RS04285	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BTL50_RS04305	COG0481	GTPase activity
BTL50_RS04310	COG0681	Belongs to the peptidase S26 family
BTL50_RS04315	COG0571	ribonuclease III activity
BTL50_RS04320	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BTL50_RS04325	COG1381	Involved in DNA repair and RecF pathway recombination
BTL50_RS04345	COG0670	Belongs to the BI1 family
BTL50_RS04360	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BTL50_RS04385	COG0583	DNA-binding transcription factor activity
BTL50_RS04405	COG0791	NLP P60 protein
BTL50_RS04410	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BTL50_RS04415	COG3193	protein, possibly involved in utilization of glycolate and propanediol
BTL50_RS04425	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BTL50_RS04445	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
BTL50_RS04480	COG1446	asparaginase
BTL50_RS04485	COG4172	Belongs to the ABC transporter superfamily
BTL50_RS04490	COG0747	negative chemotaxis
BTL50_RS04495	COG0601	transmembrane transport
BTL50_RS04520	COG0504	CTP synthase activity
BTL50_RS04530	COG0148	phosphopyruvate hydratase activity
BTL50_RS04545	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BTL50_RS04555	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BTL50_RS04560	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BTL50_RS04605	COG1981	membrane
BTL50_RS04625	COG0039	L-malate dehydrogenase activity
BTL50_RS04630	COG2188	Transcriptional regulator
BTL50_RS04635	COG2009	succinate dehydrogenase
BTL50_RS04640	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
BTL50_RS04645	COG1053	succinate dehydrogenase
BTL50_RS04650	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BTL50_RS04655	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
BTL50_RS04660	COG0372	Belongs to the citrate synthase family
BTL50_RS04675	COG0583	DNA-binding transcription factor activity
BTL50_RS04680	COG3842	ATPase activity
BTL50_RS04700	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BTL50_RS04710	COG3128	pkhd-type hydroxylase
BTL50_RS04715	COG4774	siderophore transport
BTL50_RS04725	COG0280	phosphate acetyltransferase
BTL50_RS04725	COG0281	malic enzyme
BTL50_RS04735	COG1297	OPT oligopeptide transporter protein
BTL50_RS04740	COG0567	Dehydrogenase, E1 component
BTL50_RS04745	COG0508	dehydrogenase complex catalyzes the overall conversion of
BTL50_RS04750	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BTL50_RS04755	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
BTL50_RS04760	COG1595	DNA-templated transcription, initiation
BTL50_RS04770	COG4774	siderophore transport
BTL50_RS04795	COG2183	response to ionizing radiation
BTL50_RS04800	COG1199	ATP-dependent helicase activity
BTL50_RS04810	COG0564	pseudouridine synthase activity
BTL50_RS04820	COG3243	poly(R)-hydroxyalkanoic acid synthase
BTL50_RS04825	COG1028	Short-chain dehydrogenase reductase Sdr
BTL50_RS04830	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
BTL50_RS04845	COG0672	)-iron permease
BTL50_RS04860	COG2823	Periplasmic or secreted lipoprotein
BTL50_RS04880	COG3237	CsbD-like
BTL50_RS04885	COG3038	cytochrome b561
BTL50_RS04900	COG1132	(ABC) transporter
BTL50_RS04915	COG2833	Protein of unknown function (DUF455)
BTL50_RS04920	COG2951	lytic endotransglycosylase activity
BTL50_RS04945	COG0586	Pfam SNARE associated Golgi protein
BTL50_RS04995	COG0165	Argininosuccinate lyase
BTL50_RS05015	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BTL50_RS05030	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BTL50_RS05035	COG0077	Prephenate dehydratase
BTL50_RS05035	COG1605	Chorismate mutase
BTL50_RS05040	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BTL50_RS05050	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BTL50_RS05055	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BTL50_RS05075	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
BTL50_RS05080	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
BTL50_RS05085	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BTL50_RS05090	COG0587	DNA-directed DNA polymerase activity
BTL50_RS05100	COG2951	lytic endotransglycosylase activity
BTL50_RS05105	COG0123	including yeast histone deacetylase and acetoin utilization protein
BTL50_RS05120	COG2985	domain, Protein
BTL50_RS05125	COG1960	acyl-CoA dehydrogenase activity
BTL50_RS05130	COG0450	alkyl hydroperoxide reductase
BTL50_RS05135	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
BTL50_RS05140	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
BTL50_RS05145	COG4208	sulfate ABC transporter
BTL50_RS05150	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
BTL50_RS05155	COG0175	sulfate reduction
BTL50_RS05180	COG0335	large ribosomal subunit rRNA binding
BTL50_RS05200	COG3622	Belongs to the hyi family
BTL50_RS05205	COG1162	GTPase activity
BTL50_RS05210	COG0501	Belongs to the peptidase M48B family
BTL50_RS05215	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
BTL50_RS05220	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
BTL50_RS05225	COG3327	negative regulation of DNA-templated transcription, initiation
BTL50_RS05230	COG3396	Phenylacetate-CoA oxygenase
BTL50_RS05235	COG3460	Phenylacetate-CoA oxygenase
BTL50_RS05240	COG3396	Phenylacetate-CoA oxygenase
BTL50_RS05245	COG2151	metal-sulfur cluster biosynthetic enzyme
BTL50_RS05250	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BTL50_RS05255	COG1012	belongs to the aldehyde dehydrogenase family
BTL50_RS05260	COG1024	Enoyl-CoA hydratase
BTL50_RS05265	COG2050	protein possibly involved in aromatic compounds catabolism
BTL50_RS05300	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BTL50_RS05300	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BTL50_RS05310	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BTL50_RS05315	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
BTL50_RS05320	COG2346	COG2346, Truncated hemoglobins
BTL50_RS05325	COG3642	lipopolysaccharide core region biosynthetic process
BTL50_RS05335	COG3842	ATPase activity
BTL50_RS05340	COG1176	ABC-type spermidine putrescine transport system, permease component I
BTL50_RS05345	COG1177	transmembrane transport
BTL50_RS05365	COG1322	Protein conserved in bacteria
BTL50_RS05375	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
BTL50_RS05380	COG0704	Plays a role in the regulation of phosphate uptake
BTL50_RS05385	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
BTL50_RS05390	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
BTL50_RS05390	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BTL50_RS05395	COG1643	Atp-dependent helicase
BTL50_RS05410	COG0438	transferase activity, transferring glycosyl groups
BTL50_RS05415	COG0726	polysaccharide deacetylase
BTL50_RS05420	COG0463	Glycosyl transferase, family 2
BTL50_RS05455	COG1132	(ABC) transporter
BTL50_RS05475	COG0501	Belongs to the peptidase M48B family
BTL50_RS05525	COG1722	exodeoxyribonuclease VII activity
BTL50_RS05530	COG0142	geranyltranstransferase activity
BTL50_RS05535	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BTL50_RS05540	COG1469	GTP cyclohydrolase I activity
BTL50_RS05545	COG0360	Binds together with S18 to 16S ribosomal RNA
BTL50_RS05550	COG2965	DNA replication, synthesis of RNA primer
BTL50_RS05555	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BTL50_RS05560	COG0359	binds to the 23S rRNA
BTL50_RS05570	COG0305	Participates in initiation and elongation during chromosome replication
BTL50_RS05590	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
BTL50_RS05595	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
BTL50_RS05600	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BTL50_RS05605	COG3737	Protein of unknown function (DUF498/DUF598)
BTL50_RS05610	COG0436	Aminotransferase
BTL50_RS05635	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
BTL50_RS05640	COG0308	aminopeptidase N
BTL50_RS05655	COG0312	modulator of DNA gyrase
BTL50_RS05660	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BTL50_RS05685	COG0277	FAD linked oxidase domain protein
BTL50_RS05690	COG0277	FAD linked oxidase domain protein
BTL50_RS05695	COG0247	lactate metabolic process
BTL50_RS05735	COG0583	DNA-binding transcription factor activity
BTL50_RS05740	COG0482	sulfurtransferase activity
BTL50_RS05745	COG0730	response to heat
BTL50_RS05750	COG0625	glutathione transferase activity
BTL50_RS05755	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BTL50_RS05760	COG3909	cytochrome
BTL50_RS05795	COG3706	GGDEF domain
BTL50_RS05810	COG2826	transposase and inactivated derivatives, IS30 family
BTL50_RS05830	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
BTL50_RS05855	COG0069	glutamate synthase activity
BTL50_RS05860	COG2391	methyltransferase activity
BTL50_RS05865	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
BTL50_RS05870	COG0679	Auxin Efflux Carrier
BTL50_RS05875	COG2153	protein acetylation
BTL50_RS05895	COG0557	exoribonuclease II activity
BTL50_RS05900	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BTL50_RS05905	COG2873	o-acetylhomoserine
BTL50_RS05910	COG0776	regulation of translation
BTL50_RS05940	COG0642	Histidine kinase
BTL50_RS05945	COG3158	transport of potassium into the cell
BTL50_RS05970	COG0137	argininosuccinate synthase activity
BTL50_RS05975	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BTL50_RS05980	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BTL50_RS05990	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BTL50_RS06005	COG2186	Transcriptional regulator
BTL50_RS06040	COG3836	Belongs to the HpcH HpaI aldolase family
BTL50_RS06045	COG0268	Binds directly to 16S ribosomal RNA
BTL50_RS06095	COG0728	peptidoglycan biosynthetic process
BTL50_RS06105	COG0563	adenylate kinase activity
BTL50_RS06110	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
BTL50_RS06115	COG2835	tetraacyldisaccharide 4'-kinase activity
BTL50_RS06120	COG1663	tetraacyldisaccharide 4'-kinase activity
BTL50_RS06125	COG0848	biopolymer transport protein
BTL50_RS06130	COG0811	peptide transport
BTL50_RS06135	COG1570	exodeoxyribonuclease VII activity
BTL50_RS06140	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BTL50_RS06150	COG0038	chloride channel
BTL50_RS06155	COG0183	Belongs to the thiolase family
BTL50_RS06165	COG1278	Cold shock
BTL50_RS06170	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
BTL50_RS06180	COG4953	penicillin-binding protein 1C
BTL50_RS06195	COG3008	intermembrane lipid transfer
BTL50_RS06205	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
BTL50_RS06205	COG0506	proline dehydrogenase activity
BTL50_RS06205	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
BTL50_RS06240	COG0004	ammonium transporteR
BTL50_RS06245	COG0347	Belongs to the P(II) protein family
BTL50_RS06295	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BTL50_RS06300	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BTL50_RS06305	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BTL50_RS06310	COG0072	phenylalanine-tRNA ligase activity
BTL50_RS06310	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BTL50_RS06315	COG0776	regulation of translation
BTL50_RS06345	COG1802	Transcriptional regulator
BTL50_RS06350	COG3181	Tripartite tricarboxylate transporter family receptor
BTL50_RS06370	COG1278	Cold shock
BTL50_RS06380	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BTL50_RS06400	COG1522	sequence-specific DNA binding
BTL50_RS06450	COG5265	(ABC) transporter
BTL50_RS06470	COG0656	L-ascorbic acid biosynthetic process
BTL50_RS06475	COG0667	Aldo Keto reductase
BTL50_RS06490	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BTL50_RS06535	COG1610	YqeY-like protein
BTL50_RS06550	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BTL50_RS06555	COG3246	L-lysine catabolic process to acetate
BTL50_RS06575	COG0318	PFAM AMP-dependent synthetase and ligase
BTL50_RS06590	COG0183	Belongs to the thiolase family
BTL50_RS06595	COG1024	Enoyl-CoA hydratase
BTL50_RS06595	COG1250	3-hydroxyacyl-CoA dehydrogenase
BTL50_RS06605	COG1024	Enoyl-CoA hydratase
BTL50_RS06605	COG1250	3-hydroxyacyl-CoA dehydrogenase
BTL50_RS06610	COG0183	Belongs to the thiolase family
BTL50_RS06615	COG1960	acyl-CoA dehydrogenase activity
BTL50_RS06625	COG1045	serine acetyltransferase
BTL50_RS06635	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BTL50_RS06640	COG0483	inositol monophosphate 1-phosphatase activity
BTL50_RS06645	COG1012	belongs to the aldehyde dehydrogenase family
BTL50_RS06650	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
BTL50_RS06665	COG0210	DNA helicase
BTL50_RS06670	COG0598	Magnesium transport protein CorA
BTL50_RS06680	COG0747	negative chemotaxis
BTL50_RS06685	COG0601	transmembrane transport
BTL50_RS06690	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BTL50_RS06695	COG4172	Belongs to the ABC transporter superfamily
BTL50_RS06715	COG1346	cytolysis
BTL50_RS06725	COG1028	Short-chain dehydrogenase reductase Sdr
BTL50_RS06730	COG0783	Belongs to the Dps family
BTL50_RS06750	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
BTL50_RS06760	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BTL50_RS06765	COG1845	cytochrome c oxidase, subunit III
BTL50_RS06770	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
BTL50_RS06815	COG1666	GTP binding
BTL50_RS06840	COG1028	Short-chain dehydrogenase reductase Sdr
BTL50_RS06845	COG5006	permease, DMT superfamily
BTL50_RS06870	COG2264	protein methyltransferase activity
BTL50_RS06905	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BTL50_RS06910	COG0746	molybdenum cofactor guanylyltransferase activity
BTL50_RS06915	COG0303	'Molybdopterin
BTL50_RS06920	COG0521	Mo-molybdopterin cofactor biosynthetic process
BTL50_RS06925	COG0314	molybdopterin synthase activity
BTL50_RS06935	COG0315	cyclic pyranopterin monophosphate synthase activity
BTL50_RS06940	COG0412	Dienelactone hydrolase
BTL50_RS06950	COG0678	peroxiredoxin activity
BTL50_RS06965	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BTL50_RS06975	COG0542	response to heat
BTL50_RS06985	COG1477	protein flavinylation
BTL50_RS07010	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BTL50_RS07015	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
BTL50_RS07015	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
BTL50_RS07020	COG1562	ergosterol biosynthetic process
BTL50_RS07025	COG1562	ergosterol biosynthetic process
BTL50_RS07030	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BTL50_RS07070	COG0254	rRNA binding
BTL50_RS07075	COG3483	tryptophan 2,3-dioxygenase activity
BTL50_RS07080	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
BTL50_RS07085	COG2003	Belongs to the UPF0758 family
BTL50_RS07095	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BTL50_RS07100	COG0625	glutathione transferase activity
BTL50_RS07120	COG0523	cobalamin synthesis protein
BTL50_RS07130	COG0583	DNA-binding transcription factor activity
BTL50_RS07140	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BTL50_RS07145	COG1187	pseudouridine synthase activity
BTL50_RS07150	COG0779	Required for maturation of 30S ribosomal subunits
BTL50_RS07155	COG2251	uridine kinase activity
BTL50_RS07155	COG0195	Participates in both transcription termination and antitermination
BTL50_RS07160	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BTL50_RS07165	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BTL50_RS07170	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BTL50_RS07175	COG1217	gtp-binding protein TYPA
BTL50_RS07190	COG1802	Transcriptional regulator
BTL50_RS07200	COG1024	Enoyl-CoA hydratase
BTL50_RS07205	COG0318	PFAM AMP-dependent synthetase and ligase
BTL50_RS07215	COG2032	superoxide dismutase activity
BTL50_RS07230	COG4120	Belongs to the binding-protein-dependent transport system permease family
BTL50_RS07235	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
BTL50_RS07240	COG0725	ABC transporter, periplasmic molybdate-binding protein
BTL50_RS07245	COG4149	molybdate abc transporter
BTL50_RS07275	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BTL50_RS07280	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BTL50_RS07285	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BTL50_RS07295	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
BTL50_RS07300	COG0736	holo-[acyl-carrier-protein] synthase activity
BTL50_RS07305	COG1472	Belongs to the glycosyl hydrolase 3 family
BTL50_RS07310	COG0322	excinuclease ABC activity
BTL50_RS07315	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BTL50_RS07325	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BTL50_RS07325	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BTL50_RS07330	COG2224	Isocitrate lyase
BTL50_RS07335	COG1846	Transcriptional regulator
BTL50_RS07340	COG1764	response to oxidative stress
BTL50_RS07345	COG1131	(ABC) transporter
BTL50_RS07355	COG0628	permease
BTL50_RS07370	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
BTL50_RS07380	COG2814	Major facilitator Superfamily
BTL50_RS07400	COG3015	lipoprotein NlpE involved in copper resistance
BTL50_RS07410	COG3530	Putative quorum-sensing-regulated virulence factor
BTL50_RS07425	COG0494	nUDIX hydrolase
BTL50_RS07435	COG0697	spore germination
BTL50_RS07440	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BTL50_RS07465	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BTL50_RS07470	COG1702	phosphate starvation-inducible protein PhoH
BTL50_RS07475	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BTL50_RS07480	COG4535	Mg2 and Co2 transporter CorC
BTL50_RS07485	COG0815	Transfers the fatty acyl group on membrane lipoproteins
BTL50_RS07490	COG0667	Aldo Keto reductase
BTL50_RS07510	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BTL50_RS07515	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BTL50_RS07520	COG1862	Preprotein translocase
BTL50_RS07525	COG0343	queuine tRNA-ribosyltransferase activity
BTL50_RS07530	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BTL50_RS07535	COG2027	D-alanyl-D-alanine carboxypeptidase
BTL50_RS07540	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BTL50_RS07545	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BTL50_RS07545	COG1648	precorrin-2 dehydrogenase activity
BTL50_RS07555	COG4575	ribosome binding
BTL50_RS07580	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
BTL50_RS07585	COG0741	lytic transglycosylase activity
BTL50_RS07590	COG0436	Aminotransferase
BTL50_RS07600	COG0280	phosphate acetyltransferase
BTL50_RS07600	COG0281	malic enzyme
BTL50_RS07615	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BTL50_RS07620	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BTL50_RS07625	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BTL50_RS07630	COG0126	phosphoglycerate kinase activity
BTL50_RS07645	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BTL50_RS07660	COG0625	glutathione transferase activity
BTL50_RS07680	COG0789	Transcriptional regulator
BTL50_RS07695	COG0306	phosphate transporter
BTL50_RS07700	COG0521	Mo-molybdopterin cofactor biosynthetic process
BTL50_RS07710	COG0739	heme binding
BTL50_RS07720	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BTL50_RS07760	COG0456	acetyltransferase
BTL50_RS07765	COG1301	dicarboxylic acid transport
BTL50_RS07775	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
BTL50_RS07780	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BTL50_RS07785	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BTL50_RS07790	COG0009	L-threonylcarbamoyladenylate synthase
BTL50_RS07800	COG4771	TonB-dependent receptor
BTL50_RS07830	COG1960	acyl-CoA dehydrogenase activity
BTL50_RS07835	COG0028	Belongs to the TPP enzyme family
BTL50_RS07840	COG0583	DNA-binding transcription factor activity
BTL50_RS07845	COG4974	Belongs to the 'phage' integrase family
BTL50_RS07850	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BTL50_RS07855	COG1686	Belongs to the peptidase S11 family
BTL50_RS07885	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BTL50_RS07890	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BTL50_RS07895	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BTL50_RS07915	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BTL50_RS07920	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BTL50_RS07925	COG0505	Belongs to the CarA family
BTL50_RS07930	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BTL50_RS07940	COG1028	Short-chain dehydrogenase reductase Sdr
BTL50_RS07945	COG0406	alpha-ribazole phosphatase activity
BTL50_RS07975	COG2233	PERMEase
BTL50_RS07980	COG3620	sequence-specific DNA binding
BTL50_RS07995	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BTL50_RS08005	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
BTL50_RS08010	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BTL50_RS08020	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BTL50_RS08035	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BTL50_RS08055	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BTL50_RS08115	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BTL50_RS08150	COG0540	Belongs to the ATCase OTCase family
BTL50_RS08155	COG2974	May be involved in recombination
BTL50_RS08180	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BTL50_RS08185	COG2137	regulation of response to DNA damage stimulus
BTL50_RS08195	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BTL50_RS08215	COG0045	succinate-CoA ligase (ADP-forming) activity
BTL50_RS08220	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BTL50_RS08225	COG0861	Integral membrane protein TerC family
BTL50_RS08230	COG0861	Integral membrane protein TerC family
BTL50_RS08235	COG0181	hydroxymethylbilane synthase activity
BTL50_RS08275	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BTL50_RS08320	COG1450	Type ii and iii secretion system protein
BTL50_RS08365	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BTL50_RS08375	COG1295	ribonuclease BN
BTL50_RS08385	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
BTL50_RS08405	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BTL50_RS08410	COG0501	Belongs to the peptidase M48B family
BTL50_RS08415	COG2197	response regulator
BTL50_RS08440	COG0066	3-isopropylmalate dehydratase activity
BTL50_RS08455	COG0473	3-isopropylmalate dehydrogenase activity
BTL50_RS08460	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BTL50_RS08470	COG0101	tRNA pseudouridine synthase activity
BTL50_RS08475	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
BTL50_RS08480	COG0135	phosphoribosylanthranilate isomerase activity
BTL50_RS08500	COG2801	Transposase and inactivated derivatives
BTL50_RS08505	COG2801	Transposase and inactivated derivatives
BTL50_RS08540	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BTL50_RS08545	COG2197	response regulator
BTL50_RS08550	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BTL50_RS08555	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BTL50_RS08570	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BTL50_RS08575	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BTL50_RS08585	COG1764	response to oxidative stress
BTL50_RS08600	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BTL50_RS08605	COG0765	amino acid transport
BTL50_RS08610	COG0765	amino acid transport
BTL50_RS08615	COG1126	abc transporter atp-binding protein
BTL50_RS08620	COG0756	dUTP diphosphatase activity
BTL50_RS08650	COG1522	sequence-specific DNA binding
BTL50_RS08670	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BTL50_RS08675	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BTL50_RS08680	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BTL50_RS08685	COG0196	riboflavin kinase activity
BTL50_RS08695	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BTL50_RS08695	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BTL50_RS08725	COG0210	DNA helicase
BTL50_RS08730	COG4771	TonB-dependent receptor
BTL50_RS08735	COG0488	(ABC) transporter
BTL50_RS08740	COG2890	protein-(glutamine-N5) methyltransferase activity
BTL50_RS08745	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BTL50_RS08750	COG2171	N-acyltransferase activity
BTL50_RS08805	COG2801	Transposase and inactivated derivatives
BTL50_RS08850	COG2814	Major facilitator Superfamily
BTL50_RS08875	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BTL50_RS08880	COG2900	Belongs to the SlyX family
BTL50_RS08895	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BTL50_RS08915	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BTL50_RS08940	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BTL50_RS08945	COG0583	DNA-binding transcription factor activity
BTL50_RS08950	COG1028	Short-chain dehydrogenase reductase Sdr
BTL50_RS08960	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BTL50_RS08965	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BTL50_RS08975	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BTL50_RS08980	COG0508	dehydrogenase complex catalyzes the overall conversion of
BTL50_RS08985	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
BTL50_RS08995	COG4566	intracellular signal transduction
BTL50_RS09000	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BTL50_RS09020	COG1999	signal sequence binding
BTL50_RS09040	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BTL50_RS09045	COG0583	DNA-binding transcription factor activity
BTL50_RS09050	COG1187	pseudouridine synthase activity
BTL50_RS09055	COG3161	chorismate lyase activity
BTL50_RS09070	COG1280	lysine exporter protein (LysE YggA)
BTL50_RS09105	COG1129	ABC transporter
BTL50_RS09120	COG0583	DNA-binding transcription factor activity
BTL50_RS09150	COG1185	polyribonucleotide nucleotidyltransferase activity
BTL50_RS09155	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BTL50_RS09170	COG1183	phosphatidylcholine synthase activity
BTL50_RS09180	COG0440	acetolactate synthase activity
BTL50_RS09185	COG0028	Belongs to the TPP enzyme family
BTL50_RS09210	COG3022	response to hydroperoxide
BTL50_RS09220	COG1028	Short-chain dehydrogenase reductase Sdr
BTL50_RS09235	COG3486	L-lysine 6-monooxygenase (NADPH) activity
BTL50_RS09265	COG2814	Major facilitator Superfamily
BTL50_RS09295	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BTL50_RS09330	COG2733	membrane
BTL50_RS09350	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
BTL50_RS09370	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BTL50_RS09375	COG1129	ABC transporter
BTL50_RS09375	COG0842	Transport permease protein
BTL50_RS09380	COG0842	Transport permease protein
BTL50_RS09390	COG1028	Short-chain dehydrogenase reductase Sdr
BTL50_RS09400	COG2259	Doxx family
BTL50_RS09430	COG0415	Belongs to the DNA photolyase family
BTL50_RS09450	COG0386	Belongs to the glutathione peroxidase family
BTL50_RS09465	COG0095	Lipoate-protein ligase
BTL50_RS09475	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BTL50_RS09485	COG0010	Belongs to the arginase family
BTL50_RS09495	COG0765	amino acid transport
BTL50_RS09500	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BTL50_RS09515	COG0084	hydrolase, TatD family'
BTL50_RS09525	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BTL50_RS09530	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BTL50_RS09540	COG2175	clavaminate synthase activity
BTL50_RS09545	COG0583	DNA-binding transcription factor activity
BTL50_RS09570	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
BTL50_RS09580	COG2914	Belongs to the UPF0125 (RnfH) family
BTL50_RS09590	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BTL50_RS09630	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BTL50_RS09630	COG0519	Catalyzes the synthesis of GMP from XMP
BTL50_RS09640	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
BTL50_RS09650	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BTL50_RS09655	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BTL50_RS09660	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BTL50_RS09670	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BTL50_RS09675	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BTL50_RS09685	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BTL50_RS09690	COG0750	zinc metalloprotease
BTL50_RS09695	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
BTL50_RS09705	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BTL50_RS09710	COG0233	cytoplasmic translational termination
BTL50_RS09715	COG0528	UMP kinase activity
BTL50_RS09720	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BTL50_RS09725	COG0052	Belongs to the universal ribosomal protein uS2 family
BTL50_RS09730	COG0024	Methionine aminopeptidase
BTL50_RS09735	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
BTL50_RS09755	COG1286	toxin biosynthetic process
BTL50_RS09765	COG0285	dihydrofolate synthase activity
BTL50_RS09775	COG3181	Tripartite tricarboxylate transporter family receptor
BTL50_RS09780	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BTL50_RS09820	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BTL50_RS09830	COG1677	Flagellar hook-basal body complex protein FliE
BTL50_RS09840	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BTL50_RS09845	COG1317	bacterial-type flagellum organization
BTL50_RS09865	COG1580	Controls the rotational direction of flagella during chemotaxis
BTL50_RS09875	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BTL50_RS09900	COG0840	transmembrane signaling receptor activity
BTL50_RS09905	COG0840	transmembrane signaling receptor activity
BTL50_RS09930	COG1191	sigma factor activity
BTL50_RS09970	COG2203	Gaf domain
BTL50_RS09970	COG2199	diguanylate cyclase activity
BTL50_RS09980	COG1619	proteins homologs of microcin C7 resistance protein MccF
BTL50_RS10005	COG1126	abc transporter atp-binding protein
BTL50_RS10010	COG0765	amino acid transport
BTL50_RS10015	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BTL50_RS10060	COG2200	EAL domain
BTL50_RS10080	COG1253	flavin adenine dinucleotide binding
BTL50_RS10085	COG2203	Gaf domain
BTL50_RS10085	COG3706	GGDEF domain
BTL50_RS10085	COG5001	Diguanylate cyclase
BTL50_RS10085	COG4251	negative regulation of phosphorylation
BTL50_RS10090	COG2197	response regulator
BTL50_RS10095	COG2205	protein histidine kinase activity
BTL50_RS10095	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BTL50_RS10120	COG0076	glutamate decarboxylase activity
BTL50_RS10125	COG2985	domain, Protein
BTL50_RS10130	COG3189	MarR family transcriptional regulator
BTL50_RS10140	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BTL50_RS10150	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BTL50_RS10150	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BTL50_RS10160	COG0028	Belongs to the TPP enzyme family
BTL50_RS10170	COG1012	belongs to the aldehyde dehydrogenase family
BTL50_RS10180	COG0688	phosphatidylethanolamine metabolic process
BTL50_RS10185	COG1304	FMN binding
BTL50_RS10190	COG1464	Belongs to the NlpA lipoprotein family
BTL50_RS10210	COG0697	spore germination
BTL50_RS10215	COG2133	pyrroloquinoline quinone binding
BTL50_RS10220	COG0625	glutathione transferase activity
BTL50_RS10235	COG1794	racemase activity, acting on amino acids and derivatives
BTL50_RS10255	COG0559	Belongs to the binding-protein-dependent transport system permease family
BTL50_RS10265	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BTL50_RS10280	COG1175	transmembrane transport
BTL50_RS10285	COG0395	ABC-type sugar transport system, permease component
BTL50_RS10290	COG3842	ATPase activity
BTL50_RS10315	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
BTL50_RS10330	COG0438	transferase activity, transferring glycosyl groups
BTL50_RS10355	COG0463	Glycosyl transferase, family 2
BTL50_RS10370	COG0783	Belongs to the Dps family
BTL50_RS10375	COG0583	DNA-binding transcription factor activity
BTL50_RS10380	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BTL50_RS10410	COG1840	ABC-type Fe3 transport system, periplasmic component
BTL50_RS10420	COG3842	ATPase activity
BTL50_RS10425	COG1741	Belongs to the pirin family
BTL50_RS10430	COG1741	Belongs to the pirin family
BTL50_RS10435	COG0583	DNA-binding transcription factor activity
BTL50_RS10450	COG0174	glutamine synthetase
BTL50_RS10455	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BTL50_RS10460	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BTL50_RS10470	COG0840	transmembrane signaling receptor activity
BTL50_RS10490	COG0583	DNA-binding transcription factor activity
BTL50_RS10495	COG1960	acyl-CoA dehydrogenase activity
BTL50_RS10500	COG2079	MmgE PrpD family protein
BTL50_RS10510	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
BTL50_RS10515	COG1561	YicC-like family, N-terminal region
BTL50_RS10525	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BTL50_RS10530	COG0791	NLP P60 protein
BTL50_RS10535	COG1028	Short-chain dehydrogenase reductase Sdr
BTL50_RS10540	COG0194	GDP metabolic process
BTL50_RS10545	COG1758	RNA polymerase activity
BTL50_RS10550	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BTL50_RS10555	COG1126	abc transporter atp-binding protein
BTL50_RS10560	COG0765	amino acid transport
BTL50_RS10565	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BTL50_RS10575	COG2831	hemolysin activation secretion protein
BTL50_RS10585	COG3188	usher protein
BTL50_RS10590	COG3121	Chaperone
BTL50_RS10610	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
BTL50_RS10610	COG3064	Membrane
BTL50_RS10610	COG3210	domain, Protein
BTL50_RS10610	COG3210	domain, Protein
BTL50_RS10610	COG3064	Membrane
BTL50_RS10610	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
BTL50_RS10620	COG4181	ATPase activity
BTL50_RS10630	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BTL50_RS10635	COG0584	glycerophosphoryl diester phosphodiesterase
BTL50_RS10640	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
BTL50_RS10650	COG0678	peroxiredoxin activity
BTL50_RS10650	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
BTL50_RS10660	COG2217	Heavy metal translocating P-type atpase
BTL50_RS10665	COG0789	Transcriptional regulator
BTL50_RS10670	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BTL50_RS10705	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BTL50_RS10715	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
BTL50_RS10740	COG0583	DNA-binding transcription factor activity
BTL50_RS10745	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BTL50_RS10750	COG2252	PERMEase
BTL50_RS10755	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BTL50_RS10760	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BTL50_RS10795	COG0488	(ABC) transporter
BTL50_RS10800	COG1619	proteins homologs of microcin C7 resistance protein MccF
BTL50_RS10805	COG0590	tRNA wobble adenosine to inosine editing
BTL50_RS10820	COG1320	monovalent cation:proton antiporter activity
BTL50_RS10825	COG2212	antiporter activity
BTL50_RS10830	COG1863	multisubunit Na H antiporter MnhE subunit
BTL50_RS10835	COG0651	ATP synthesis coupled electron transport
BTL50_RS10840	COG1006	Multisubunit Na H antiporter MnhC subunit
BTL50_RS10845	COG2111	Na H antiporter
BTL50_RS10845	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BTL50_RS10850	COG3181	Tripartite tricarboxylate transporter family receptor
BTL50_RS10875	COG0420	3'-5' exonuclease activity
BTL50_RS10910	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BTL50_RS10920	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
BTL50_RS10930	COG2130	NADP-dependent
BTL50_RS10935	COG1309	transcriptional regulator
BTL50_RS10945	COG1131	(ABC) transporter
BTL50_RS10950	COG0842	Transport permease protein
BTL50_RS10960	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BTL50_RS10995	COG0602	queuosine metabolic process
BTL50_RS11000	COG0720	synthase
BTL50_RS11035	COG0587	DNA-directed DNA polymerase activity
BTL50_RS11045	COG0390	transport system, permease component
BTL50_RS11050	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BTL50_RS11055	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
BTL50_RS11110	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BTL50_RS11135	COG5507	3-demethylubiquinone-9 3-methyltransferase
BTL50_RS11170	COG1396	sequence-specific DNA binding
BTL50_RS11195	COG0583	DNA-binding transcription factor activity
BTL50_RS11200	COG2814	Major facilitator Superfamily
BTL50_RS11225	COG2807	transmembrane transport
BTL50_RS11230	COG2207	Transcriptional regulator
BTL50_RS11235	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BTL50_RS11240	COG2814	Major facilitator Superfamily
BTL50_RS11255	COG1012	belongs to the aldehyde dehydrogenase family
BTL50_RS11290	COG0583	DNA-binding transcription factor activity
BTL50_RS11310	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BTL50_RS11335	COG0384	phenazine biosynthesis protein PhzF
BTL50_RS11340	COG1733	regulation of RNA biosynthetic process
BTL50_RS11375	COG3177	Filamentation induced by cAMP protein fic
BTL50_RS11385	COG0519	Catalyzes the synthesis of GMP from XMP
BTL50_RS11385	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BTL50_RS11400	COG1695	Transcriptional regulator
BTL50_RS11415	COG2072	flavoprotein involved in K transport
BTL50_RS11420	COG0601	transmembrane transport
BTL50_RS11440	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BTL50_RS11450	COG4608	Belongs to the ABC transporter superfamily
BTL50_RS11455	COG0747	negative chemotaxis
BTL50_RS11495	COG0047	phosphoribosylformylglycinamidine synthase activity
BTL50_RS11495	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BTL50_RS11500	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BTL50_RS11520	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BTL50_RS11520	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BTL50_RS11525	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BTL50_RS11535	COG0613	PHP domain protein
BTL50_RS11595	COG1012	belongs to the aldehyde dehydrogenase family
BTL50_RS11605	COG0583	DNA-binding transcription factor activity
BTL50_RS11625	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BTL50_RS11635	COG3181	Tripartite tricarboxylate transporter family receptor
BTL50_RS11645	COG3181	Tripartite tricarboxylate transporter family receptor
BTL50_RS11675	COG1595	DNA-templated transcription, initiation
BTL50_RS11680	COG3712	iron ion homeostasis
BTL50_RS11690	COG0084	hydrolase, TatD family'
BTL50_RS11695	COG1136	(ABC) transporter
BTL50_RS11710	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BTL50_RS11720	COG1028	Short-chain dehydrogenase reductase Sdr
BTL50_RS11725	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BTL50_RS11735	COG1803	Methylglyoxal synthase
BTL50_RS11755	COG2801	Transposase and inactivated derivatives
BTL50_RS11760	COG2801	Transposase and inactivated derivatives
BTL50_RS11785	COG2975	iron-sulfur cluster assembly
BTL50_RS11790	COG0633	Ferredoxin
BTL50_RS11795	COG0443	Heat shock 70 kDa protein
BTL50_RS11800	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
BTL50_RS11805	COG0316	Belongs to the HesB IscA family
BTL50_RS11810	COG0822	iron-sulfur transferase activity
BTL50_RS11815	COG1104	cysteine desulfurase activity
BTL50_RS11825	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BTL50_RS11830	COG0556	nucleotide-excision repair
BTL50_RS11845	COG0583	DNA-binding transcription factor activity
BTL50_RS11865	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BTL50_RS11905	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BTL50_RS11920	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BTL50_RS11930	COG0740	serine-type endopeptidase activity
BTL50_RS11935	COG0544	peptidyl-prolyl cis-trans isomerase activity
BTL50_RS11975	COG2801	Transposase and inactivated derivatives
BTL50_RS11985	COG1278	Cold shock
BTL50_RS12015	COG2433	Pfam Transposase IS66
BTL50_RS12075	COG1530	ribonuclease E activity
BTL50_RS12105	COG1846	Transcriptional regulator
BTL50_RS12115	COG1566	PFAM secretion protein HlyD family protein
BTL50_RS12120	COG2814	Major facilitator Superfamily
BTL50_RS12125	COG0473	3-isopropylmalate dehydrogenase activity
BTL50_RS12145	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BTL50_RS12150	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BTL50_RS12155	COG0433	COG0433 Predicted ATPase
BTL50_RS12160	COG0217	transcriptional regulatory protein
BTL50_RS12165	COG0151	Belongs to the GarS family
BTL50_RS12175	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BTL50_RS12180	COG0799	negative regulation of ribosome biogenesis
BTL50_RS12185	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BTL50_RS12190	COG0424	maF-like protein
BTL50_RS12200	COG4191	Histidine kinase
BTL50_RS12205	COG2204	response regulator
BTL50_RS12230	COG0500	methyltransferase
BTL50_RS12245	COG0803	Belongs to the bacterial solute-binding protein 9 family
BTL50_RS12250	COG1121	(ABC) transporter
BTL50_RS12255	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BTL50_RS12260	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BTL50_RS12290	COG4993	Dehydrogenase
BTL50_RS12300	COG4772	TonB-dependent receptor
BTL50_RS12305	COG2814	Major facilitator Superfamily
BTL50_RS12325	COG0037	tRNA processing
BTL50_RS12330	COG0825	malonyl-CoA metabolic process
BTL50_RS12340	COG0215	cysteine-tRNA ligase activity
BTL50_RS12350	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BTL50_RS12355	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BTL50_RS12360	COG1968	undecaprenyl-diphosphatase activity
BTL50_RS12365	COG1253	flavin adenine dinucleotide binding
BTL50_RS12370	COG0483	inositol monophosphate 1-phosphatase activity
BTL50_RS12390	COG0668	transmembrane transport
BTL50_RS12415	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BTL50_RS12425	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
BTL50_RS12440	COG1802	Transcriptional regulator
BTL50_RS12460	COG3360	Dodecin
BTL50_RS12480	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BTL50_RS12485	COG2850	peptidyl-arginine hydroxylation
BTL50_RS12495	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
BTL50_RS12500	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BTL50_RS12505	COG1994	Peptidase M50
BTL50_RS12510	COG0009	L-threonylcarbamoyladenylate synthase
BTL50_RS12515	COG2321	neutral zinc metallopeptidase
BTL50_RS12535	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BTL50_RS12545	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BTL50_RS12555	COG2271	Major facilitator Superfamily
BTL50_RS12630	COG2202	Pas domain
BTL50_RS12630	COG2200	EAL domain
BTL50_RS12630	COG2199	diguanylate cyclase activity
BTL50_RS12635	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
BTL50_RS12655	COG1960	acyl-CoA dehydrogenase activity
BTL50_RS12660	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BTL50_RS12665	COG2186	Transcriptional regulator
BTL50_RS12690	COG1595	DNA-templated transcription, initiation
BTL50_RS12725	COG1028	Short-chain dehydrogenase reductase Sdr
BTL50_RS12740	COG0179	Fumarylacetoacetate (FAA) hydrolase
BTL50_RS12760	COG4604	ABC transporter, ATP-binding protein
BTL50_RS12765	COG4605	iron ion homeostasis
BTL50_RS12770	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BTL50_RS12775	COG4607	ABC-type enterochelin transport system periplasmic component
BTL50_RS12780	COG0438	transferase activity, transferring glycosyl groups
BTL50_RS12790	COG0149	triose-phosphate isomerase activity
BTL50_RS12795	COG0604	alcohol dehydrogenase
BTL50_RS12795	COG4221	oxidoreductase activity
BTL50_RS12795	COG3321	synthase
BTL50_RS12795	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BTL50_RS12825	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BTL50_RS12825	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BTL50_RS12830	COG0668	transmembrane transport
BTL50_RS12835	COG0165	Argininosuccinate lyase
BTL50_RS12845	COG0789	Transcriptional regulator
BTL50_RS12855	COG0501	Belongs to the peptidase M48B family
BTL50_RS12860	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BTL50_RS12885	COG1024	Enoyl-CoA hydratase
BTL50_RS12890	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BTL50_RS12910	COG3468	outer membrane autotransporter barrel domain protein
BTL50_RS12950	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BTL50_RS12955	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BTL50_RS12960	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
BTL50_RS12965	COG1674	ftsk spoiiie
BTL50_RS12970	COG0492	ferredoxin-NADP+ reductase activity
BTL50_RS12975	COG1193	negative regulation of DNA recombination
BTL50_RS12990	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BTL50_RS13005	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
BTL50_RS13010	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
BTL50_RS13015	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
BTL50_RS13025	COG0745	RESPONSE REGULATOR receiver
BTL50_RS13060	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BTL50_RS13080	COG0612	Peptidase, M16
BTL50_RS13090	COG0443	Heat shock 70 kDa protein
BTL50_RS13100	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BTL50_RS13110	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
BTL50_RS13115	COG1420	regulation of RNA biosynthetic process
BTL50_RS13120	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BTL50_RS13125	COG0497	DNA recombination
BTL50_RS13155	COG0735	belongs to the Fur family
BTL50_RS13160	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BTL50_RS13205	COG2828	Protein conserved in bacteria
BTL50_RS13210	COG1280	lysine exporter protein (LysE YggA)
BTL50_RS13215	COG3181	Tripartite tricarboxylate transporter family receptor
BTL50_RS13230	COG1028	Short-chain dehydrogenase reductase Sdr
BTL50_RS13235	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
BTL50_RS13240	COG1802	Transcriptional regulator
BTL50_RS13245	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
BTL50_RS13250	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BTL50_RS13255	COG1335	isochorismatase
BTL50_RS13260	COG0523	cobalamin synthesis protein
BTL50_RS13290	COG0583	DNA-binding transcription factor activity
BTL50_RS13300	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
BTL50_RS13305	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
BTL50_RS13310	COG0167	dihydroorotate dehydrogenase activity
BTL50_RS13360	COG1414	Transcriptional regulator
BTL50_RS13380	COG0513	Belongs to the DEAD box helicase family
BTL50_RS13405	COG0429	hydrolase of the alpha beta-hydrolase fold
BTL50_RS13450	COG0006	proline dipeptidase activity
BTL50_RS13460	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BTL50_RS13485	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
BTL50_RS13490	COG0632	four-way junction helicase activity
BTL50_RS13505	COG2255	four-way junction helicase activity
BTL50_RS13510	COG0514	ATP-dependent DNA helicase (RecQ)
BTL50_RS13530	COG1294	oxidase, subunit
BTL50_RS13540	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BTL50_RS13545	COG0850	regulation of cytokinetic process
BTL50_RS13550	COG2894	cell division
BTL50_RS13555	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
BTL50_RS13580	COG0488	(ABC) transporter
BTL50_RS13595	COG4608	Belongs to the ABC transporter superfamily
BTL50_RS13600	COG0444	Belongs to the ABC transporter superfamily
BTL50_RS13605	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BTL50_RS13620	COG1215	transferase activity, transferring glycosyl groups
BTL50_RS13625	COG0583	DNA-binding transcription factor activity
BTL50_RS13630	COG1368	sulfuric ester hydrolase activity
BTL50_RS13635	COG1686	Belongs to the peptidase S11 family
BTL50_RS13645	COG1280	lysine exporter protein (LysE YggA)
BTL50_RS13655	COG1064	alcohol dehydrogenase
BTL50_RS13660	COG4191	Histidine kinase
BTL50_RS13665	COG4566	intracellular signal transduction
BTL50_RS13675	COG1802	Transcriptional regulator
BTL50_RS13700	COG3181	Tripartite tricarboxylate transporter family receptor
BTL50_RS13705	COG0513	Belongs to the DEAD box helicase family
BTL50_RS13710	COG0668	transmembrane transport
BTL50_RS13725	COG1595	DNA-templated transcription, initiation
BTL50_RS13765	COG0583	DNA-binding transcription factor activity
BTL50_RS13770	COG0531	amino acid
BTL50_RS13775	COG1982	Orn Lys Arg decarboxylase major
BTL50_RS13800	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BTL50_RS13805	COG0459	protein refolding
BTL50_RS13815	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
BTL50_RS13820	COG1252	NADH dehydrogenase
BTL50_RS13825	COG0284	orotidine-5'-phosphate decarboxylase activity
BTL50_RS13835	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BTL50_RS13845	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BTL50_RS13850	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BTL50_RS13880	COG1595	DNA-templated transcription, initiation
BTL50_RS13890	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
BTL50_RS13895	COG3639	organic phosphonate transmembrane transporter activity
BTL50_RS13900	COG3639	organic phosphonate transmembrane transporter activity
BTL50_RS13915	COG0742	ribosomal rna small subunit methyltransferase
BTL50_RS13920	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BTL50_RS13925	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
BTL50_RS13930	COG3135	benzoate transporter
BTL50_RS13950	COG4774	siderophore transport
BTL50_RS13975	COG1024	Enoyl-CoA hydratase
BTL50_RS13980	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BTL50_RS13985	COG1960	acyl-CoA dehydrogenase activity
BTL50_RS13995	COG0318	PFAM AMP-dependent synthetase and ligase
BTL50_RS14000	COG3181	Tripartite tricarboxylate transporter family receptor
BTL50_RS14010	COG0583	DNA-binding transcription factor activity
BTL50_RS14035	COG0277	FAD linked oxidase domain protein
BTL50_RS14055	COG1802	Transcriptional regulator
BTL50_RS14065	COG2271	Major facilitator Superfamily
BTL50_RS14075	COG0583	DNA-binding transcription factor activity
BTL50_RS14100	COG0012	GTP binding
BTL50_RS14110	COG0193	aminoacyl-tRNA hydrolase activity
BTL50_RS14115	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
BTL50_RS14120	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BTL50_RS14130	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BTL50_RS14145	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BTL50_RS14170	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
BTL50_RS14180	COG1368	sulfuric ester hydrolase activity
BTL50_RS14185	COG2186	Transcriptional regulator
BTL50_RS14195	COG3181	Tripartite tricarboxylate transporter family receptor
BTL50_RS14210	COG0277	FAD linked oxidase domain protein
BTL50_RS14225	COG0166	Belongs to the GPI family
BTL50_RS14230	COG0438	transferase activity, transferring glycosyl groups
BTL50_RS14235	COG0438	transferase activity, transferring glycosyl groups
BTL50_RS14250	COG0438	transferase activity, transferring glycosyl groups
BTL50_RS14265	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
BTL50_RS14270	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BTL50_RS14285	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
BTL50_RS14295	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BTL50_RS14305	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BTL50_RS14310	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BTL50_RS14325	COG0747	negative chemotaxis
BTL50_RS14335	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BTL50_RS14340	COG4172	Belongs to the ABC transporter superfamily
BTL50_RS14360	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BTL50_RS14360	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BTL50_RS14365	COG0509	glycine decarboxylation via glycine cleavage system
BTL50_RS14370	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BTL50_RS14375	COG2081	HI0933 family
BTL50_RS14390	COG0456	acetyltransferase
BTL50_RS14395	COG0717	Belongs to the dCTP deaminase family
BTL50_RS14410	COG0489	protein tyrosine kinase activity
BTL50_RS14420	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BTL50_RS14420	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BTL50_RS14445	COG3539	Fimbrial protein
BTL50_RS14460	COG0745	RESPONSE REGULATOR receiver
BTL50_RS14485	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
BTL50_RS14500	COG2084	Dehydrogenase
BTL50_RS14505	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BTL50_RS14530	COG3842	ATPase activity
BTL50_RS14535	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
BTL50_RS14540	COG1960	acyl-CoA dehydrogenase activity
BTL50_RS14550	COG0583	DNA-binding transcription factor activity
BTL50_RS14560	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BTL50_RS14565	COG1024	Enoyl-CoA hydratase
BTL50_RS14580	COG0583	DNA-binding transcription factor activity
BTL50_RS14585	COG1408	metallophosphoesterase
BTL50_RS14590	COG0625	glutathione transferase activity
BTL50_RS14625	COG0426	domain, Protein
BTL50_RS14625	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BTL50_RS14630	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BTL50_RS14635	COG0583	DNA-binding transcription factor activity
BTL50_RS14645	COG1024	Enoyl-CoA hydratase
BTL50_RS14655	COG1960	acyl-CoA dehydrogenase activity
BTL50_RS14660	COG1028	Short-chain dehydrogenase reductase Sdr
BTL50_RS14665	COG1028	Short-chain dehydrogenase reductase Sdr
BTL50_RS14685	COG3181	Tripartite tricarboxylate transporter family receptor
BTL50_RS14690	COG1028	Short-chain dehydrogenase reductase Sdr
BTL50_RS14700	COG3181	Tripartite tricarboxylate transporter family receptor
BTL50_RS14740	COG0583	DNA-binding transcription factor activity
BTL50_RS14745	COG1960	acyl-CoA dehydrogenase activity
BTL50_RS14750	COG3181	Tripartite tricarboxylate transporter family receptor
BTL50_RS14755	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BTL50_RS14760	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BTL50_RS14785	COG0560	Phosphoserine phosphatase
BTL50_RS14790	COG0583	DNA-binding transcription factor activity
BTL50_RS14805	COG3842	ATPase activity
BTL50_RS14820	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BTL50_RS14840	COG0625	glutathione transferase activity
BTL50_RS14885	COG4336	lyase activity
BTL50_RS14895	COG0326	Molecular chaperone. Has ATPase activity
BTL50_RS14900	COG2233	PERMEase
BTL50_RS14940	COG2818	Glycosylase
BTL50_RS14945	COG0727	PFAM Uncharacterised protein family (UPF0153)
BTL50_RS14970	COG0402	S-adenosylhomocysteine deaminase activity
BTL50_RS14980	COG0156	8-amino-7-oxononanoate synthase activity
BTL50_RS14985	COG2877	3-deoxy-8-phosphooctulonate synthase activity
BTL50_RS15040	COG1464	Belongs to the NlpA lipoprotein family
BTL50_RS15045	COG2011	ABC-type metal ion transport system permease component
BTL50_RS15050	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BTL50_RS15055	COG1501	Belongs to the glycosyl hydrolase 31 family
BTL50_RS15060	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
BTL50_RS15060	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BTL50_RS15065	COG0483	inositol monophosphate 1-phosphatase activity
BTL50_RS15070	COG0318	PFAM AMP-dependent synthetase and ligase
BTL50_RS15075	COG1473	amidohydrolase
BTL50_RS15080	COG0583	DNA-binding transcription factor activity
BTL50_RS15085	COG2855	membrane
BTL50_RS15095	COG2239	Acts as a magnesium transporter
BTL50_RS15110	COG1522	sequence-specific DNA binding
BTL50_RS15150	COG0330	HflC and HflK could
BTL50_RS15155	COG0330	HflC and HflK could
BTL50_RS15160	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BTL50_RS15165	COG1923	regulation of RNA biosynthetic process
BTL50_RS15175	COG1160	GTP binding
BTL50_RS15180	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BTL50_RS15185	COG2976	Protein conserved in bacteria
BTL50_RS15190	COG0124	histidyl-tRNA synthetase
BTL50_RS15205	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BTL50_RS15210	COG0105	UTP biosynthetic process
BTL50_RS15215	COG0525	valine-tRNA ligase activity
BTL50_RS15225	COG0336	Belongs to the RNA methyltransferase TrmD family
BTL50_RS15230	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BTL50_RS15235	COG0228	four-way junction DNA binding
BTL50_RS15240	COG0425	Belongs to the sulfur carrier protein TusA family
BTL50_RS15245	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BTL50_RS15310	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BTL50_RS15315	COG0543	2 iron, 2 sulfur cluster binding
BTL50_RS15315	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BTL50_RS15320	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
BTL50_RS15325	COG2076	Multidrug Resistance protein
BTL50_RS15330	COG3217	Mosc domain protein beta barrel domain protein
BTL50_RS15330	COG0633	Ferredoxin
BTL50_RS15335	COG5285	phytanoyl-CoA dioxygenase
BTL50_RS15340	COG0662	Cupin 2, conserved barrel domain protein
BTL50_RS15350	COG0456	acetyltransferase
BTL50_RS15370	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BTL50_RS15400	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BTL50_RS15410	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
BTL50_RS15415	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BTL50_RS15420	COG1760	l-serine dehydratase
BTL50_RS15425	COG1283	sodium-dependent phosphate transmembrane transporter activity
BTL50_RS15430	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BTL50_RS15435	COG0412	Dienelactone hydrolase
BTL50_RS15440	COG0428	transporter
BTL50_RS15450	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BTL50_RS15455	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BTL50_RS15460	COG1845	cytochrome c oxidase, subunit III
BTL50_RS15465	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
BTL50_RS15475	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BTL50_RS15475	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BTL50_RS15500	COG1942	4-Oxalocrotonate Tautomerase
BTL50_RS15510	COG4176	ABC-type proline glycine betaine transport system permease component
BTL50_RS15530	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BTL50_RS15535	COG2814	Major facilitator Superfamily
BTL50_RS15540	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BTL50_RS15545	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BTL50_RS15570	COG1846	Transcriptional regulator
BTL50_RS15575	COG2814	Major facilitator Superfamily
BTL50_RS15580	COG0495	leucyl-tRNA aminoacylation
BTL50_RS15595	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BTL50_RS15615	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BTL50_RS15620	COG2274	protein secretion by the type I secretion system
BTL50_RS15665	COG0427	acetyl-CoA hydrolase
BTL50_RS15675	COG3264	Mechanosensitive ion channel
BTL50_RS15675	COG1511	domain protein
BTL50_RS15680	COG0730	response to heat
BTL50_RS15695	COG2176	DNA-directed DNA polymerase activity
BTL50_RS15715	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
BTL50_RS15720	COG3384	dioxygenase
BTL50_RS15735	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BTL50_RS15805	COG4964	Belongs to the GSP D family
BTL50_RS15850	COG1846	Transcriptional regulator
BTL50_RS15885	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
BTL50_RS15895	COG2070	2-Nitropropane dioxygenase
BTL50_RS15900	COG2070	2-Nitropropane dioxygenase
BTL50_RS15910	COG2610	gluconate transmembrane transporter activity
BTL50_RS15925	COG1408	metallophosphoesterase
BTL50_RS15930	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
BTL50_RS15930	COG0493	'glutamate synthase
BTL50_RS15935	COG2199	diguanylate cyclase activity
BTL50_RS15940	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
BTL50_RS15975	COG2159	amidohydrolase
BTL50_RS15985	COG0583	DNA-binding transcription factor activity
BTL50_RS16000	COG1024	Enoyl-CoA hydratase
BTL50_RS16005	COG2186	Transcriptional regulator
BTL50_RS16010	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BTL50_RS16020	COG0833	amino acid
BTL50_RS16030	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
BTL50_RS16065	COG5265	(ABC) transporter
BTL50_RS16105	COG1971	Probably functions as a manganese efflux pump
BTL50_RS16110	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BTL50_RS16120	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BTL50_RS16125	COG2814	Major facilitator Superfamily
BTL50_RS16150	COG4608	Belongs to the ABC transporter superfamily
BTL50_RS16170	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BTL50_RS16180	COG3383	formate dehydrogenase (NAD+) activity
BTL50_RS16195	COG0747	negative chemotaxis
BTL50_RS16205	COG0625	glutathione transferase activity
BTL50_RS16235	COG1595	DNA-templated transcription, initiation
BTL50_RS16245	COG4774	siderophore transport
BTL50_RS16260	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BTL50_RS16275	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
BTL50_RS16280	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
BTL50_RS16305	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BTL50_RS16310	COG1024	Enoyl-CoA hydratase
BTL50_RS16345	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BTL50_RS16350	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BTL50_RS16355	COG1116	anion transmembrane transporter activity
BTL50_RS16360	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BTL50_RS16365	COG3585	molybdate ion transport
BTL50_RS16425	COG0583	DNA-binding transcription factor activity
BTL50_RS16430	COG4948	Mandelate Racemase Muconate Lactonizing
BTL50_RS16435	COG3181	Tripartite tricarboxylate transporter family receptor
BTL50_RS16465	COG3181	Tripartite tricarboxylate transporter family receptor
BTL50_RS16500	COG4177	L-phenylalanine transmembrane transporter activity
BTL50_RS16525	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BTL50_RS16540	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BTL50_RS16545	COG1538	Outer membrane efflux protein
BTL50_RS16550	COG1136	(ABC) transporter
BTL50_RS16550	COG0577	efflux transmembrane transporter activity
BTL50_RS16555	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BTL50_RS16570	COG0259	pyridoxamine-phosphate oxidase activity
BTL50_RS16575	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BTL50_RS16580	COG0579	oxidoreductase
BTL50_RS16590	COG0405	Gamma-glutamyltransferase
BTL50_RS16600	COG3181	Tripartite tricarboxylate transporter family receptor
BTL50_RS16610	COG0114	fumarate hydratase activity
BTL50_RS16615	COG0802	atpase or kinase
BTL50_RS16620	COG0860	N-Acetylmuramoyl-L-alanine amidase
BTL50_RS16625	COG0586	Pfam SNARE associated Golgi protein
BTL50_RS16630	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BTL50_RS16635	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BTL50_RS16640	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BTL50_RS16655	COG0617	tRNA 3'-terminal CCA addition
BTL50_RS16690	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
BTL50_RS16700	COG1024	Enoyl-CoA hydratase
BTL50_RS16710	COG2188	Transcriptional regulator
BTL50_RS16715	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BTL50_RS16730	COG0752	glycyl-tRNA synthetase alpha subunit
BTL50_RS16735	COG0751	glycine-tRNA ligase activity
BTL50_RS16740	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
BTL50_RS16745	COG0204	Acyl-transferase
BTL50_RS16775	COG0242	peptide deformylase activity
BTL50_RS16785	COG0700	Nucleoside recognition
BTL50_RS16790	COG0469	pyruvate kinase activity
BTL50_RS16795	COG1929	Belongs to the glycerate kinase type-1 family
BTL50_RS16805	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BTL50_RS16810	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BTL50_RS16815	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
BTL50_RS16825	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
BTL50_RS16835	COG2154	pterin-4-alpha-carbinolamine dehydratase
BTL50_RS16840	COG2885	chlorophyll binding
BTL50_RS16850	COG0667	Aldo Keto reductase
BTL50_RS16860	COG3181	Tripartite tricarboxylate transporter family receptor
BTL50_RS16880	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BTL50_RS16885	COG0288	reversible hydration of carbon dioxide
BTL50_RS16905	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BTL50_RS16915	COG4829	muconolactone delta-isomerase
BTL50_RS16920	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
BTL50_RS16930	COG1414	Transcriptional regulator
BTL50_RS16935	COG1028	Short-chain dehydrogenase reductase Sdr
BTL50_RS16940	COG2031	fatty acid transporter
BTL50_RS16945	COG1250	3-hydroxyacyl-CoA dehydrogenase
BTL50_RS16955	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
BTL50_RS16960	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
BTL50_RS16975	COG0129	dihydroxy-acid dehydratase activity
BTL50_RS16980	COG1609	Transcriptional regulator
BTL50_RS17000	COG4106	trans-aconitate 2-methyltransferase activity
BTL50_RS17020	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BTL50_RS17060	COG0163	prenyltransferase activity
BTL50_RS17065	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BTL50_RS17070	COG2890	protein-(glutamine-N5) methyltransferase activity
BTL50_RS17075	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BTL50_RS17080	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
BTL50_RS17095	COG3712	iron ion homeostasis
BTL50_RS17130	COG0659	secondary active sulfate transmembrane transporter activity
BTL50_RS17150	COG1028	Short-chain dehydrogenase reductase Sdr
BTL50_RS17165	COG4774	siderophore transport
BTL50_RS17175	COG1595	DNA-templated transcription, initiation
BTL50_RS17190	COG0142	geranyltranstransferase activity
BTL50_RS17195	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BTL50_RS17200	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BTL50_RS17205	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BTL50_RS17210	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BTL50_RS17230	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BTL50_RS17230	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BTL50_RS17235	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
BTL50_RS17250	COG0583	DNA-binding transcription factor activity
BTL50_RS17255	COG0861	Integral membrane protein TerC family
BTL50_RS17270	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BTL50_RS17275	COG0793	Belongs to the peptidase S41A family
BTL50_RS17280	COG4942	peptidase
BTL50_RS17285	COG0588	phosphoglycerate mutase activity
BTL50_RS17295	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
BTL50_RS17300	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
BTL50_RS17305	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BTL50_RS17310	COG3181	Tripartite tricarboxylate transporter family receptor
BTL50_RS17325	COG2226	methyltransferase
BTL50_RS17330	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
BTL50_RS17335	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BTL50_RS17345	COG2204	response regulator
BTL50_RS17350	COG5000	phosphorelay sensor kinase activity
BTL50_RS17360	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BTL50_RS17360	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BTL50_RS17400	COG2188	Transcriptional regulator
BTL50_RS17415	COG0583	DNA-binding transcription factor activity
BTL50_RS17420	COG1012	belongs to the aldehyde dehydrogenase family
BTL50_RS17440	COG0546	phosphoglycolate phosphatase activity
BTL50_RS17455	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BTL50_RS17460	COG0242	peptide deformylase activity
BTL50_RS17470	COG1522	sequence-specific DNA binding
BTL50_RS17475	COG2879	small protein
BTL50_RS17480	COG1966	Carbon starvation protein
BTL50_RS17510	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BTL50_RS17515	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BTL50_RS17520	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BTL50_RS17525	COG3181	Tripartite tricarboxylate transporter family receptor
BTL50_RS17590	COG1172	Belongs to the binding-protein-dependent transport system permease family
BTL50_RS17625	COG0640	Transcriptional regulator
BTL50_RS17665	COG0735	belongs to the Fur family
BTL50_RS17670	COG2207	Transcriptional regulator
BTL50_RS17675	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BTL50_RS17680	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BTL50_RS17685	COG0513	Belongs to the DEAD box helicase family
BTL50_RS17715	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BTL50_RS17730	COG1305	Transglutaminase-like
BTL50_RS17770	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BTL50_RS17775	COG1950	PFAM Membrane protein of
BTL50_RS17800	COG0024	Methionine aminopeptidase
BTL50_RS17805	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BTL50_RS17815	COG1560	Kdo2-lipid A biosynthetic process
BTL50_RS17820	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BTL50_RS17830	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
BTL50_RS17865	COG0735	belongs to the Fur family
BTL50_RS17870	COG0523	cobalamin synthesis protein
BTL50_RS17885	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
BTL50_RS17895	COG2096	Adenosyltransferase
BTL50_RS17900	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BTL50_RS17905	COG0321	lipoyl(octanoyl) transferase activity
BTL50_RS17915	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BTL50_RS17920	COG1686	Belongs to the peptidase S11 family
BTL50_RS17945	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BTL50_RS17955	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
BTL50_RS17965	COG0859	PFAM glycosyl transferase family 9
BTL50_RS18000	COG0477	Major facilitator Superfamily
BTL50_RS18015	COG3568	Endonuclease Exonuclease Phosphatase
BTL50_RS18020	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BTL50_RS18050	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BTL50_RS18055	COG1956	GAF domain-containing protein
BTL50_RS18060	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BTL50_RS18075	COG2186	Transcriptional regulator
BTL50_RS18080	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
BTL50_RS18095	COG1840	ABC-type Fe3 transport system, periplasmic component
BTL50_RS18135	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BTL50_RS18140	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BTL50_RS18145	COG1086	Polysaccharide biosynthesis protein
BTL50_RS18180	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
BTL50_RS18190	COG1028	Short-chain dehydrogenase reductase Sdr
BTL50_RS18195	COG1012	belongs to the aldehyde dehydrogenase family
BTL50_RS18220	COG1522	sequence-specific DNA binding
BTL50_RS18225	COG3781	membrane
BTL50_RS18265	COG2200	EAL domain
BTL50_RS18275	COG0592	DNA-directed DNA polymerase activity
BTL50_RS18280	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BTL50_RS18285	COG0230	Belongs to the bacterial ribosomal protein bL34 family
BTL50_RS18290	COG0594	ribonuclease P activity
BTL50_RS18295	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
BTL50_RS18300	COG0706	membrane insertase activity
BTL50_RS18305	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
BTL50_RS18310	COG1473	amidohydrolase
BTL50_RS18315	COG4608	Belongs to the ABC transporter superfamily
BTL50_RS18320	COG0444	Belongs to the ABC transporter superfamily
BTL50_RS18325	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BTL50_RS18330	COG0601	transmembrane transport
BTL50_RS18340	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BTL50_RS18345	COG1505	serine-type exopeptidase activity
BTL50_RS18355	COG0281	malic enzyme
BTL50_RS18355	COG0280	phosphate acetyltransferase
BTL50_RS18385	COG0436	Aminotransferase
BTL50_RS18390	COG1278	Cold shock