locus-tag	class	description
H558_RS00025	COG1846	Transcriptional regulator
H558_RS00035	COG1566	PFAM secretion protein HlyD family protein
H558_RS00040	COG2814	Major facilitator Superfamily
H558_RS00065	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H558_RS00070	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H558_RS00075	COG0433	COG0433 Predicted ATPase
H558_RS00080	COG0217	transcriptional regulatory protein
H558_RS00085	COG0151	Belongs to the GarS family
H558_RS00095	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
H558_RS00100	COG0799	negative regulation of ribosome biogenesis
H558_RS00105	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
H558_RS00110	COG0424	maF-like protein
H558_RS00120	COG4191	Histidine kinase
H558_RS00125	COG2204	response regulator
H558_RS00150	COG0500	methyltransferase
H558_RS00165	COG0803	Belongs to the bacterial solute-binding protein 9 family
H558_RS00170	COG1121	(ABC) transporter
H558_RS00175	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H558_RS00180	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H558_RS00195	COG4993	Dehydrogenase
H558_RS00205	COG4772	TonB-dependent receptor
H558_RS00210	COG2814	Major facilitator Superfamily
H558_RS00230	COG0037	tRNA processing
H558_RS00235	COG0825	malonyl-CoA metabolic process
H558_RS00245	COG0215	cysteine-tRNA ligase activity
H558_RS00255	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H558_RS00260	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H558_RS00265	COG1968	undecaprenyl-diphosphatase activity
H558_RS00270	COG1253	flavin adenine dinucleotide binding
H558_RS00275	COG0483	inositol monophosphate 1-phosphatase activity
H558_RS00295	COG0668	transmembrane transport
H558_RS00320	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H558_RS00330	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
H558_RS00345	COG1802	Transcriptional regulator
H558_RS00365	COG3360	Dodecin
H558_RS00385	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
H558_RS00390	COG2850	peptidyl-arginine hydroxylation
H558_RS00400	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
H558_RS00405	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H558_RS00410	COG1994	Peptidase M50
H558_RS00415	COG0009	L-threonylcarbamoyladenylate synthase
H558_RS00420	COG2321	neutral zinc metallopeptidase
H558_RS00440	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H558_RS00450	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H558_RS00455	COG2271	Major facilitator Superfamily
H558_RS00480	COG2801	Transposase and inactivated derivatives
H558_RS00485	COG2963	transposase activity
H558_RS00530	COG2200	EAL domain
H558_RS00530	COG2202	Pas domain
H558_RS00530	COG2199	diguanylate cyclase activity
H558_RS00535	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
H558_RS00555	COG1960	acyl-CoA dehydrogenase activity
H558_RS00560	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H558_RS00565	COG2186	Transcriptional regulator
H558_RS00590	COG1595	DNA-templated transcription, initiation
H558_RS00610	COG2801	Transposase and inactivated derivatives
H558_RS00625	COG1028	Short-chain dehydrogenase reductase Sdr
H558_RS00635	COG0179	Fumarylacetoacetate (FAA) hydrolase
H558_RS00655	COG4604	ABC transporter, ATP-binding protein
H558_RS00660	COG4605	iron ion homeostasis
H558_RS00665	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H558_RS00670	COG4607	ABC-type enterochelin transport system periplasmic component
H558_RS00675	COG0438	transferase activity, transferring glycosyl groups
H558_RS00685	COG0149	triose-phosphate isomerase activity
H558_RS00690	COG4221	oxidoreductase activity
H558_RS00690	COG3321	synthase
H558_RS00690	COG0604	alcohol dehydrogenase
H558_RS00690	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H558_RS00715	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H558_RS00715	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H558_RS00720	COG0668	transmembrane transport
H558_RS00725	COG0165	Argininosuccinate lyase
H558_RS00735	COG0789	Transcriptional regulator
H558_RS00745	COG0501	Belongs to the peptidase M48B family
H558_RS00750	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H558_RS00775	COG1024	Enoyl-CoA hydratase
H558_RS00780	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H558_RS00800	COG3468	outer membrane autotransporter barrel domain protein
H558_RS00805	COG2801	Transposase and inactivated derivatives
H558_RS00810	COG2801	Transposase and inactivated derivatives
H558_RS00840	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H558_RS00845	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H558_RS00850	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
H558_RS00855	COG1674	ftsk spoiiie
H558_RS00860	COG0492	ferredoxin-NADP+ reductase activity
H558_RS00865	COG1193	negative regulation of DNA recombination
H558_RS00880	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H558_RS00890	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
H558_RS00895	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
H558_RS00900	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
H558_RS00905	COG2205	protein histidine kinase activity
H558_RS00910	COG0745	RESPONSE REGULATOR receiver
H558_RS00945	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H558_RS00965	COG0612	Peptidase, M16
H558_RS00975	COG0443	Heat shock 70 kDa protein
H558_RS00985	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H558_RS00995	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H558_RS01000	COG1420	regulation of RNA biosynthetic process
H558_RS01005	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H558_RS01010	COG0497	DNA recombination
H558_RS01020	COG2801	Transposase and inactivated derivatives
H558_RS01035	COG0735	belongs to the Fur family
H558_RS01040	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H558_RS01060	COG2801	Transposase and inactivated derivatives
H558_RS01070	COG2801	Transposase and inactivated derivatives
H558_RS01090	COG2828	Protein conserved in bacteria
H558_RS01095	COG1280	lysine exporter protein (LysE YggA)
H558_RS01100	COG3181	Tripartite tricarboxylate transporter family receptor
H558_RS01115	COG1028	Short-chain dehydrogenase reductase Sdr
H558_RS01120	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
H558_RS01125	COG1802	Transcriptional regulator
H558_RS01130	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
H558_RS01135	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H558_RS01140	COG1335	isochorismatase
H558_RS01145	COG0523	cobalamin synthesis protein
H558_RS01175	COG0583	DNA-binding transcription factor activity
H558_RS01185	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
H558_RS01190	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
H558_RS01195	COG0167	dihydroorotate dehydrogenase activity
H558_RS01210	COG2801	Transposase and inactivated derivatives
H558_RS01235	COG1414	Transcriptional regulator
H558_RS01255	COG0513	Belongs to the DEAD box helicase family
H558_RS01280	COG0429	hydrolase of the alpha beta-hydrolase fold
H558_RS01310	COG2801	Transposase and inactivated derivatives
H558_RS01325	COG0006	proline dipeptidase activity
H558_RS01335	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H558_RS01365	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
H558_RS01370	COG0632	four-way junction helicase activity
H558_RS01385	COG2255	four-way junction helicase activity
H558_RS01390	COG0514	ATP-dependent DNA helicase (RecQ)
H558_RS01410	COG1294	oxidase, subunit
H558_RS01420	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H558_RS01425	COG0850	regulation of cytokinetic process
H558_RS01430	COG2894	cell division
H558_RS01435	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
H558_RS01455	COG0488	(ABC) transporter
H558_RS01470	COG4608	Belongs to the ABC transporter superfamily
H558_RS01475	COG0444	Belongs to the ABC transporter superfamily
H558_RS01480	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H558_RS01495	COG1215	transferase activity, transferring glycosyl groups
H558_RS01500	COG0583	DNA-binding transcription factor activity
H558_RS01505	COG1368	sulfuric ester hydrolase activity
H558_RS01510	COG1686	Belongs to the peptidase S11 family
H558_RS01520	COG1280	lysine exporter protein (LysE YggA)
H558_RS01530	COG1064	alcohol dehydrogenase
H558_RS01535	COG4191	Histidine kinase
H558_RS01540	COG4566	intracellular signal transduction
H558_RS01550	COG1802	Transcriptional regulator
H558_RS01575	COG3181	Tripartite tricarboxylate transporter family receptor
H558_RS01580	COG0513	Belongs to the DEAD box helicase family
H558_RS01585	COG0668	transmembrane transport
H558_RS01600	COG1595	DNA-templated transcription, initiation
H558_RS01640	COG0583	DNA-binding transcription factor activity
H558_RS01645	COG0531	amino acid
H558_RS01650	COG1982	Orn Lys Arg decarboxylase major
H558_RS01670	COG2801	Transposase and inactivated derivatives
H558_RS01675	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
H558_RS01680	COG0459	protein refolding
H558_RS01690	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
H558_RS01695	COG1252	NADH dehydrogenase
H558_RS01700	COG0284	orotidine-5'-phosphate decarboxylase activity
H558_RS01710	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
H558_RS01720	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H558_RS01725	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
H558_RS01755	COG1595	DNA-templated transcription, initiation
H558_RS01765	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
H558_RS01770	COG3639	organic phosphonate transmembrane transporter activity
H558_RS01775	COG3639	organic phosphonate transmembrane transporter activity
H558_RS01790	COG0742	ribosomal rna small subunit methyltransferase
H558_RS01795	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H558_RS01800	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H558_RS01805	COG3135	benzoate transporter
H558_RS01825	COG4774	siderophore transport
H558_RS01850	COG1024	Enoyl-CoA hydratase
H558_RS01855	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H558_RS01860	COG1960	acyl-CoA dehydrogenase activity
H558_RS01870	COG0318	PFAM AMP-dependent synthetase and ligase
H558_RS01875	COG3181	Tripartite tricarboxylate transporter family receptor
H558_RS01885	COG0583	DNA-binding transcription factor activity
H558_RS01910	COG0277	FAD linked oxidase domain protein
H558_RS01930	COG1802	Transcriptional regulator
H558_RS01940	COG2271	Major facilitator Superfamily
H558_RS01950	COG0583	DNA-binding transcription factor activity
H558_RS01955	COG4774	siderophore transport
H558_RS01980	COG0012	GTP binding
H558_RS01990	COG0193	aminoacyl-tRNA hydrolase activity
H558_RS01995	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
H558_RS02000	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H558_RS02010	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
H558_RS02025	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H558_RS02035	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H558_RS02055	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
H558_RS02065	COG1368	sulfuric ester hydrolase activity
H558_RS02070	COG2186	Transcriptional regulator
H558_RS02080	COG3181	Tripartite tricarboxylate transporter family receptor
H558_RS02095	COG0277	FAD linked oxidase domain protein
H558_RS02110	COG0166	Belongs to the GPI family
H558_RS02115	COG0438	transferase activity, transferring glycosyl groups
H558_RS02120	COG0438	transferase activity, transferring glycosyl groups
H558_RS02135	COG0438	transferase activity, transferring glycosyl groups
H558_RS02150	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
H558_RS02155	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H558_RS02165	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
H558_RS02175	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
H558_RS02185	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H558_RS02190	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H558_RS02205	COG0747	negative chemotaxis
H558_RS02215	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H558_RS02220	COG4172	Belongs to the ABC transporter superfamily
H558_RS02240	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H558_RS02240	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H558_RS02245	COG0509	glycine decarboxylation via glycine cleavage system
H558_RS02250	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H558_RS02255	COG2081	HI0933 family
H558_RS02270	COG0456	acetyltransferase
H558_RS02275	COG0717	Belongs to the dCTP deaminase family
H558_RS02290	COG0489	protein tyrosine kinase activity
H558_RS02300	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H558_RS02300	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H558_RS02325	COG3539	Fimbrial protein
H558_RS02340	COG0745	RESPONSE REGULATOR receiver
H558_RS02360	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H558_RS02365	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
H558_RS02380	COG2084	Dehydrogenase
H558_RS02385	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H558_RS02410	COG3842	ATPase activity
H558_RS02415	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
H558_RS02420	COG1960	acyl-CoA dehydrogenase activity
H558_RS02430	COG0583	DNA-binding transcription factor activity
H558_RS02440	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H558_RS02445	COG1024	Enoyl-CoA hydratase
H558_RS02460	COG0583	DNA-binding transcription factor activity
H558_RS02465	COG1408	metallophosphoesterase
H558_RS02470	COG0625	glutathione transferase activity
H558_RS02505	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H558_RS02505	COG0426	domain, Protein
H558_RS02510	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H558_RS02515	COG0583	DNA-binding transcription factor activity
H558_RS02525	COG1024	Enoyl-CoA hydratase
H558_RS02535	COG1960	acyl-CoA dehydrogenase activity
H558_RS02540	COG1028	Short-chain dehydrogenase reductase Sdr
H558_RS02545	COG1028	Short-chain dehydrogenase reductase Sdr
H558_RS02565	COG3181	Tripartite tricarboxylate transporter family receptor
H558_RS02570	COG1028	Short-chain dehydrogenase reductase Sdr
H558_RS02580	COG3181	Tripartite tricarboxylate transporter family receptor
H558_RS02620	COG0583	DNA-binding transcription factor activity
H558_RS02625	COG1960	acyl-CoA dehydrogenase activity
H558_RS02630	COG3181	Tripartite tricarboxylate transporter family receptor
H558_RS02635	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H558_RS02640	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H558_RS02660	COG2801	Transposase and inactivated derivatives
H558_RS02665	COG0560	Phosphoserine phosphatase
H558_RS02670	COG0583	DNA-binding transcription factor activity
H558_RS02680	COG3842	ATPase activity
H558_RS02695	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H558_RS02715	COG0625	glutathione transferase activity
H558_RS02760	COG4336	lyase activity
H558_RS02770	COG0326	Molecular chaperone. Has ATPase activity
H558_RS02775	COG2233	PERMEase
H558_RS02795	COG2801	Transposase and inactivated derivatives
H558_RS02810	COG2982	Protein involved in outer membrane biogenesis
H558_RS02815	COG2982	Protein involved in outer membrane biogenesis
H558_RS02820	COG2818	Glycosylase
H558_RS02825	COG0727	PFAM Uncharacterised protein family (UPF0153)
H558_RS02850	COG0402	S-adenosylhomocysteine deaminase activity
H558_RS02860	COG0156	8-amino-7-oxononanoate synthase activity
H558_RS02865	COG2877	3-deoxy-8-phosphooctulonate synthase activity
H558_RS02890	COG2801	Transposase and inactivated derivatives
H558_RS02915	COG1464	Belongs to the NlpA lipoprotein family
H558_RS02920	COG2011	ABC-type metal ion transport system permease component
H558_RS02925	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H558_RS02930	COG1501	Belongs to the glycosyl hydrolase 31 family
H558_RS02935	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
H558_RS02935	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H558_RS02940	COG0483	inositol monophosphate 1-phosphatase activity
H558_RS02945	COG0318	PFAM AMP-dependent synthetase and ligase
H558_RS02950	COG1473	amidohydrolase
H558_RS02955	COG0583	DNA-binding transcription factor activity
H558_RS02960	COG2855	membrane
H558_RS02970	COG2239	Acts as a magnesium transporter
H558_RS02985	COG1522	sequence-specific DNA binding
H558_RS03005	COG2801	Transposase and inactivated derivatives
H558_RS03025	COG0330	HflC and HflK could
H558_RS03030	COG0330	HflC and HflK could
H558_RS03035	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H558_RS03040	COG1923	regulation of RNA biosynthetic process
H558_RS03050	COG1160	GTP binding
H558_RS03055	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H558_RS03060	COG2976	Protein conserved in bacteria
H558_RS03065	COG0124	histidyl-tRNA synthetase
H558_RS03080	COG0820	rRNA (adenine-C2-)-methyltransferase activity
H558_RS03085	COG0105	UTP biosynthetic process
H558_RS03090	COG0525	valine-tRNA ligase activity
H558_RS03100	COG0336	Belongs to the RNA methyltransferase TrmD family
H558_RS03105	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H558_RS03110	COG0228	four-way junction DNA binding
H558_RS03115	COG0425	Belongs to the sulfur carrier protein TusA family
H558_RS03120	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H558_RS03170	COG2801	Transposase and inactivated derivatives
H558_RS03185	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H558_RS03190	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H558_RS03190	COG0543	2 iron, 2 sulfur cluster binding
H558_RS03195	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
H558_RS03200	COG2076	Multidrug Resistance protein
H558_RS03205	COG0633	Ferredoxin
H558_RS03205	COG3217	Mosc domain protein beta barrel domain protein
H558_RS03210	COG5285	phytanoyl-CoA dioxygenase
H558_RS03215	COG0662	Cupin 2, conserved barrel domain protein
H558_RS03225	COG0456	acetyltransferase
H558_RS03245	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H558_RS03250	COG2311	Membrane
H558_RS03275	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
H558_RS03285	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
H558_RS03290	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H558_RS03295	COG1760	l-serine dehydratase
H558_RS03300	COG1283	sodium-dependent phosphate transmembrane transporter activity
H558_RS03305	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H558_RS03310	COG0412	Dienelactone hydrolase
H558_RS03315	COG0428	transporter
H558_RS03325	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H558_RS03335	COG1845	cytochrome c oxidase, subunit III
H558_RS03340	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
H558_RS03350	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H558_RS03350	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H558_RS03375	COG1942	4-Oxalocrotonate Tautomerase
H558_RS03385	COG4176	ABC-type proline glycine betaine transport system permease component
H558_RS03400	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H558_RS03405	COG2814	Major facilitator Superfamily
H558_RS03410	COG0227	Belongs to the bacterial ribosomal protein bL28 family
H558_RS03415	COG0267	Belongs to the bacterial ribosomal protein bL33 family
H558_RS03440	COG1846	Transcriptional regulator
H558_RS03445	COG2814	Major facilitator Superfamily
H558_RS03450	COG0495	leucyl-tRNA aminoacylation
H558_RS03465	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
H558_RS03485	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H558_RS03490	COG2274	protein secretion by the type I secretion system
H558_RS03505	COG2801	Transposase and inactivated derivatives
H558_RS03535	COG0427	acetyl-CoA hydrolase
H558_RS03545	COG1511	domain protein
H558_RS03545	COG3264	Mechanosensitive ion channel
H558_RS03550	COG0730	response to heat
H558_RS03565	COG2176	DNA-directed DNA polymerase activity
H558_RS03585	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
H558_RS03590	COG3384	dioxygenase
H558_RS03605	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H558_RS03630	COG2801	Transposase and inactivated derivatives
H558_RS03675	COG4964	Belongs to the GSP D family
H558_RS03715	COG1846	Transcriptional regulator
H558_RS03750	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
H558_RS03760	COG2070	2-Nitropropane dioxygenase
H558_RS03765	COG2070	2-Nitropropane dioxygenase
H558_RS03775	COG2610	gluconate transmembrane transporter activity
H558_RS03790	COG1408	metallophosphoesterase
H558_RS03800	COG2199	diguanylate cyclase activity
H558_RS03805	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
H558_RS03840	COG2159	amidohydrolase
H558_RS03850	COG0583	DNA-binding transcription factor activity
H558_RS03865	COG1024	Enoyl-CoA hydratase
H558_RS03870	COG2186	Transcriptional regulator
H558_RS03875	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H558_RS03885	COG0833	amino acid
H558_RS03890	COG2894	cell division
H558_RS03895	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
H558_RS03930	COG5265	(ABC) transporter
H558_RS03970	COG1971	Probably functions as a manganese efflux pump
H558_RS03975	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H558_RS03985	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H558_RS03990	COG2814	Major facilitator Superfamily
H558_RS04015	COG4608	Belongs to the ABC transporter superfamily
H558_RS04035	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H558_RS04045	COG3383	formate dehydrogenase (NAD+) activity
H558_RS04060	COG0747	negative chemotaxis
H558_RS04070	COG0625	glutathione transferase activity
H558_RS04100	COG1595	DNA-templated transcription, initiation
H558_RS04110	COG4774	siderophore transport
H558_RS04125	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H558_RS04140	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
H558_RS04145	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
H558_RS04170	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H558_RS04175	COG1024	Enoyl-CoA hydratase
H558_RS04210	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H558_RS04215	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H558_RS04220	COG1116	anion transmembrane transporter activity
H558_RS04230	COG3585	molybdate ion transport
H558_RS04290	COG0583	DNA-binding transcription factor activity
H558_RS04295	COG4948	Mandelate Racemase Muconate Lactonizing
H558_RS04300	COG3181	Tripartite tricarboxylate transporter family receptor
H558_RS04325	COG3181	Tripartite tricarboxylate transporter family receptor
H558_RS04330	COG3181	Tripartite tricarboxylate transporter family receptor
H558_RS04365	COG4177	L-phenylalanine transmembrane transporter activity
H558_RS04390	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H558_RS04405	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H558_RS04410	COG1538	Outer membrane efflux protein
H558_RS04415	COG1136	(ABC) transporter
H558_RS04415	COG0577	efflux transmembrane transporter activity
H558_RS04420	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H558_RS04435	COG0259	pyridoxamine-phosphate oxidase activity
H558_RS04440	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
H558_RS04445	COG0579	oxidoreductase
H558_RS04455	COG0405	Gamma-glutamyltransferase
H558_RS04465	COG3181	Tripartite tricarboxylate transporter family receptor
H558_RS04475	COG0114	fumarate hydratase activity
H558_RS04480	COG0802	atpase or kinase
H558_RS04485	COG0860	N-Acetylmuramoyl-L-alanine amidase
H558_RS04490	COG0586	Pfam SNARE associated Golgi protein
H558_RS04495	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H558_RS04500	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H558_RS04505	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H558_RS04520	COG0617	tRNA 3'-terminal CCA addition
H558_RS04540	COG2801	Transposase and inactivated derivatives
H558_RS04560	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
H558_RS04570	COG1024	Enoyl-CoA hydratase
H558_RS04580	COG2188	Transcriptional regulator
H558_RS04585	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H558_RS04600	COG0752	glycyl-tRNA synthetase alpha subunit
H558_RS04605	COG0751	glycine-tRNA ligase activity
H558_RS04610	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
H558_RS04615	COG0204	Acyl-transferase
H558_RS04645	COG0242	peptide deformylase activity
H558_RS04655	COG0700	Nucleoside recognition
H558_RS04660	COG0469	pyruvate kinase activity
H558_RS04665	COG1929	Belongs to the glycerate kinase type-1 family
H558_RS04675	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
H558_RS04685	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
H558_RS04695	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H558_RS04705	COG2154	pterin-4-alpha-carbinolamine dehydratase
H558_RS04710	COG2885	chlorophyll binding
H558_RS04720	COG0667	Aldo Keto reductase
H558_RS04730	COG3181	Tripartite tricarboxylate transporter family receptor
H558_RS04735	COG2801	Transposase and inactivated derivatives
H558_RS04750	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H558_RS04755	COG0288	reversible hydration of carbon dioxide
H558_RS04775	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H558_RS04785	COG4829	muconolactone delta-isomerase
H558_RS04790	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
H558_RS04795	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
H558_RS04800	COG1414	Transcriptional regulator
H558_RS04805	COG1028	Short-chain dehydrogenase reductase Sdr
H558_RS04810	COG2031	fatty acid transporter
H558_RS04815	COG1250	3-hydroxyacyl-CoA dehydrogenase
H558_RS04825	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
H558_RS04830	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H558_RS04845	COG0129	dihydroxy-acid dehydratase activity
H558_RS04850	COG1609	Transcriptional regulator
H558_RS04875	COG4106	trans-aconitate 2-methyltransferase activity
H558_RS04890	COG0820	rRNA (adenine-C2-)-methyltransferase activity
H558_RS04920	COG2801	Transposase and inactivated derivatives
H558_RS04930	COG0163	prenyltransferase activity
H558_RS04935	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H558_RS04940	COG2890	protein-(glutamine-N5) methyltransferase activity
H558_RS04945	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H558_RS04950	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
H558_RS04965	COG3712	iron ion homeostasis
H558_RS05000	COG0659	secondary active sulfate transmembrane transporter activity
H558_RS05020	COG1028	Short-chain dehydrogenase reductase Sdr
H558_RS05030	COG4774	siderophore transport
H558_RS05040	COG1595	DNA-templated transcription, initiation
H558_RS05055	COG0142	geranyltranstransferase activity
H558_RS05060	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H558_RS05065	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H558_RS05070	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
H558_RS05075	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
H558_RS05090	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H558_RS05090	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H558_RS05095	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
H558_RS05105	COG0583	DNA-binding transcription factor activity
H558_RS05110	COG0861	Integral membrane protein TerC family
H558_RS05125	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H558_RS05130	COG0793	Belongs to the peptidase S41A family
H558_RS05135	COG4942	peptidase
H558_RS05140	COG0588	phosphoglycerate mutase activity
H558_RS05150	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H558_RS05155	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
H558_RS05160	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H558_RS05165	COG3181	Tripartite tricarboxylate transporter family receptor
H558_RS05180	COG2226	methyltransferase
H558_RS05185	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
H558_RS05190	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H558_RS05200	COG2204	response regulator
H558_RS05205	COG5000	phosphorelay sensor kinase activity
H558_RS05215	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H558_RS05215	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H558_RS05250	COG2188	Transcriptional regulator
H558_RS05265	COG0583	DNA-binding transcription factor activity
H558_RS05270	COG1012	belongs to the aldehyde dehydrogenase family
H558_RS05290	COG0546	phosphoglycolate phosphatase activity
H558_RS05305	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H558_RS05310	COG0242	peptide deformylase activity
H558_RS05320	COG1522	sequence-specific DNA binding
H558_RS05325	COG2879	small protein
H558_RS05330	COG1966	Carbon starvation protein
H558_RS05360	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H558_RS05365	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H558_RS05370	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
H558_RS05375	COG3181	Tripartite tricarboxylate transporter family receptor
H558_RS05440	COG1172	Belongs to the binding-protein-dependent transport system permease family
H558_RS05475	COG0640	Transcriptional regulator
H558_RS05515	COG0735	belongs to the Fur family
H558_RS05520	COG2207	Transcriptional regulator
H558_RS05525	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H558_RS05530	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
H558_RS05535	COG0513	Belongs to the DEAD box helicase family
H558_RS05560	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H558_RS05575	COG1305	Transglutaminase-like
H558_RS05615	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
H558_RS05620	COG1950	PFAM Membrane protein of
H558_RS05645	COG0024	Methionine aminopeptidase
H558_RS05650	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H558_RS05660	COG1560	Kdo2-lipid A biosynthetic process
H558_RS05665	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
H558_RS05675	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
H558_RS05710	COG0735	belongs to the Fur family
H558_RS05715	COG0523	cobalamin synthesis protein
H558_RS05730	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
H558_RS05740	COG2096	Adenosyltransferase
H558_RS05745	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H558_RS05750	COG0321	lipoyl(octanoyl) transferase activity
H558_RS05760	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H558_RS05765	COG1686	Belongs to the peptidase S11 family
H558_RS05790	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H558_RS05800	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
H558_RS05810	COG0859	PFAM glycosyl transferase family 9
H558_RS05845	COG0477	Major facilitator Superfamily
H558_RS05860	COG3568	Endonuclease Exonuclease Phosphatase
H558_RS05865	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H558_RS05895	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H558_RS05900	COG1956	GAF domain-containing protein
H558_RS05905	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H558_RS05920	COG2186	Transcriptional regulator
H558_RS05925	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
H558_RS05940	COG1840	ABC-type Fe3 transport system, periplasmic component
H558_RS05985	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H558_RS05990	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H558_RS05995	COG1086	Polysaccharide biosynthesis protein
H558_RS06025	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
H558_RS06035	COG1028	Short-chain dehydrogenase reductase Sdr
H558_RS06040	COG1012	belongs to the aldehyde dehydrogenase family
H558_RS06045	COG2801	Transposase and inactivated derivatives
H558_RS06065	COG1522	sequence-specific DNA binding
H558_RS06070	COG3781	membrane
H558_RS06090	COG2801	Transposase and inactivated derivatives
H558_RS06095	COG2801	Transposase and inactivated derivatives
H558_RS06110	COG2200	EAL domain
H558_RS06120	COG0592	DNA-directed DNA polymerase activity
H558_RS06125	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H558_RS06130	COG0230	Belongs to the bacterial ribosomal protein bL34 family
H558_RS06135	COG0594	ribonuclease P activity
H558_RS06140	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
H558_RS06145	COG0706	membrane insertase activity
H558_RS06150	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
H558_RS06155	COG1473	amidohydrolase
H558_RS06160	COG4608	Belongs to the ABC transporter superfamily
H558_RS06165	COG0444	Belongs to the ABC transporter superfamily
H558_RS06170	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H558_RS06175	COG0601	transmembrane transport
H558_RS06185	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
H558_RS06190	COG1505	serine-type exopeptidase activity
H558_RS06200	COG0280	phosphate acetyltransferase
H558_RS06200	COG0281	malic enzyme
H558_RS06230	COG0436	Aminotransferase
H558_RS06235	COG1278	Cold shock
H558_RS06240	COG0445	tRNA wobble uridine modification
H558_RS06245	COG0357	Ribosomal RNA small subunit methyltransferase G
H558_RS06250	COG1192	Involved in chromosome partitioning
H558_RS06255	COG1475	DNA binding
H558_RS06260	COG0252	asparaginase activity
H558_RS06280	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H558_RS06290	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H558_RS06300	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
H558_RS06305	COG0081	regulation of translation
H558_RS06310	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H558_RS06315	COG0222	ribosome binding
H558_RS06320	COG0085	RNA polymerase activity
H558_RS06325	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H558_RS06365	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H558_RS06370	COG0049	tRNA binding
H558_RS06375	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H558_RS06380	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H558_RS06385	COG0051	transcription antitermination factor activity, RNA binding
H558_RS06390	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H558_RS06395	COG0088	Forms part of the polypeptide exit tunnel
H558_RS06400	COG0089	rRNA binding
H558_RS06405	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H558_RS06410	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H558_RS06415	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
H558_RS06420	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
H558_RS06425	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
H558_RS06430	COG0255	Belongs to the universal ribosomal protein uL29 family
H558_RS06435	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
H558_RS06460	COG0411	ABC transporter
H558_RS06490	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
H558_RS06495	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
H558_RS06500	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H558_RS06505	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
H558_RS06510	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H558_RS06515	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
H558_RS06520	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
H558_RS06525	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
H558_RS06530	COG1841	ribosomal large subunit assembly
H558_RS06535	COG0200	Binds to the 23S rRNA
H558_RS06540	COG0201	protein transport
H558_RS06545	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
H558_RS06550	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H558_RS06555	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
H558_RS06560	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
H558_RS06565	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
H558_RS06570	COG0202	RNA polymerase activity
H558_RS06575	COG0203	ribosomal protein L17
H558_RS06580	COG0537	adenosine 5'-monophosphoramidase activity
H558_RS06585	COG1324	tolerance protein
H558_RS06590	COG4232	protein-disulfide reductase activity
H558_RS06605	COG0218	Necessary for normal cell division and for the maintenance of normal septation
H558_RS06615	COG1333	cytochrome c biogenesis protein
H558_RS06620	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H558_RS06630	COG1965	Belongs to the frataxin family
H558_RS06640	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H558_RS06645	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
H558_RS06650	COG0232	Belongs to the dGTPase family. Type 2 subfamily
H558_RS06670	COG2814	Major facilitator Superfamily
H558_RS06690	COG2801	Transposase and inactivated derivatives
H558_RS06730	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H558_RS06735	COG2922	Belongs to the Smg family
H558_RS06740	COG1629	transport
H558_RS06750	COG2358	TRAP transporter, solute receptor (TAXI family
H558_RS06760	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H558_RS06775	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H558_RS06780	COG0183	Belongs to the thiolase family
H558_RS06785	COG1960	acyl-CoA dehydrogenase activity
H558_RS06810	COG2200	EAL domain
H558_RS06815	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H558_RS06825	COG0018	arginyl-trna synthetase
H558_RS06840	COG0154	amidase activity
H558_RS06845	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H558_RS06855	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
H558_RS06865	COG0697	spore germination
H558_RS06895	COG2151	metal-sulfur cluster biosynthetic enzyme
H558_RS06930	COG3350	monooxygenase activity
H558_RS06955	COG1309	transcriptional regulator
H558_RS06990	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
H558_RS06995	COG1280	lysine exporter protein (LysE YggA)
H558_RS07000	COG0513	Belongs to the DEAD box helicase family
H558_RS07010	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
H558_RS07015	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
H558_RS07045	COG2969	positive regulation of protein catabolic process
H558_RS07050	COG0625	glutathione transferase activity
H558_RS07055	COG2857	Cytochrome c1
H558_RS07060	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H558_RS07065	COG0723	plastoquinol--plastocyanin reductase activity
H558_RS07070	COG1970	mechanosensitive ion channel activity
H558_RS07075	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
H558_RS07080	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H558_RS07090	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H558_RS07095	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H558_RS07105	COG0140	phosphoribosyl-ATP diphosphatase activity
H558_RS07110	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H558_RS07115	COG0107	imidazoleglycerol-phosphate synthase activity
H558_RS07120	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
H558_RS07130	COG0131	Imidazoleglycerol-phosphate dehydratase
H558_RS07135	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H558_RS07140	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H558_RS07145	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H558_RS07150	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H558_RS07155	COG0271	Belongs to the BolA IbaG family
H558_RS07160	COG0842	Transport permease protein
H558_RS07165	COG1131	(ABC) transporter
H558_RS07180	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H558_RS07185	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H558_RS07190	COG1127	ABC transporter
H558_RS07210	COG0067	glutamate synthase
H558_RS07210	COG0069	glutamate synthase activity
H558_RS07210	COG0070	glutamate synthase
H558_RS07230	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
H558_RS07250	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H558_RS07255	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
H558_RS07275	COG2801	Transposase and inactivated derivatives
H558_RS07295	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H558_RS07330	COG0109	protoheme IX farnesyltransferase activity
H558_RS07335	COG1999	signal sequence binding
H558_RS07355	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H558_RS07360	COG2814	Major facilitator Superfamily
H558_RS07375	COG1522	sequence-specific DNA binding
H558_RS07425	COG4948	Mandelate Racemase Muconate Lactonizing
H558_RS07440	COG3119	arylsulfatase activity
H558_RS07460	COG2801	Transposase and inactivated derivatives
H558_RS07475	COG0402	S-adenosylhomocysteine deaminase activity
H558_RS07485	COG1304	FMN binding
H558_RS07490	COG1254	Belongs to the acylphosphatase family
H558_RS07500	COG3181	Tripartite tricarboxylate transporter family receptor
H558_RS07510	COG1414	Transcriptional regulator
H558_RS07520	COG2801	Transposase and inactivated derivatives
H558_RS07530	COG0028	Belongs to the TPP enzyme family
H558_RS07535	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
H558_RS07540	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H558_RS07545	COG1960	acyl-CoA dehydrogenase activity
H558_RS07580	COG3181	Tripartite tricarboxylate transporter family receptor
H558_RS07585	COG0583	DNA-binding transcription factor activity
H558_RS07600	COG0129	dihydroxy-acid dehydratase activity
H558_RS07605	COG2084	Dehydrogenase
H558_RS07620	COG1671	Belongs to the UPF0178 family
H558_RS07625	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
H558_RS07635	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
H558_RS07640	COG0443	Heat shock 70 kDa protein
H558_RS07660	COG2169	Transcriptional regulator
H558_RS07660	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H558_RS07675	COG1683	Conserved Protein
H558_RS07680	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H558_RS07695	COG1120	ATPase activity
H558_RS07700	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H558_RS07705	COG4558	Periplasmic binding protein
H558_RS07710	COG3720	iron ion transport
H558_RS07720	COG3712	iron ion homeostasis
H558_RS07725	COG1595	DNA-templated transcription, initiation
H558_RS07745	COG1607	acyl-coa hydrolase
H558_RS07755	COG3383	formate dehydrogenase (NAD+) activity
H558_RS07755	COG0243	molybdopterin cofactor binding
H558_RS07760	COG0243	molybdopterin cofactor binding
H558_RS07760	COG3383	formate dehydrogenase (NAD+) activity
H558_RS07765	COG0437	4 iron, 4 sulfur cluster binding
H558_RS07770	COG2864	formate dehydrogenase
H558_RS07785	COG3276	selenocysteine insertion sequence binding
H558_RS07825	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H558_RS07830	COG0512	Glutamine amidotransferase of anthranilate synthase
H558_RS07840	COG0546	phosphoglycolate phosphatase activity
H558_RS07845	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H558_RS07850	COG2967	ApaG domain
H558_RS07855	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
H558_RS07860	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H558_RS07865	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H558_RS07870	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H558_RS07875	COG0037	tRNA processing
H558_RS07895	COG1024	Enoyl-CoA hydratase
H558_RS07910	COG0356	it plays a direct role in the translocation of protons across the membrane
H558_RS07920	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H558_RS07925	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H558_RS07930	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
H558_RS07935	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
H558_RS07940	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H558_RS07945	COG0355	proton-transporting ATP synthase activity, rotational mechanism
H558_RS07960	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
H558_RS07965	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H558_RS07970	COG0210	DNA helicase
H558_RS07985	COG4608	Belongs to the ABC transporter superfamily
H558_RS07990	COG0444	Belongs to the ABC transporter superfamily
H558_RS07995	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H558_RS08020	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H558_RS08025	COG1024	Enoyl-CoA hydratase
H558_RS08030	COG1024	Enoyl-CoA hydratase
H558_RS08035	COG2070	2-Nitropropane dioxygenase
H558_RS08050	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H558_RS08055	COG1250	3-hydroxyacyl-CoA dehydrogenase
H558_RS08075	COG2267	carboxylic ester hydrolase activity
H558_RS08095	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
H558_RS08100	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H558_RS08105	COG2813	Specifically methylates the guanine in position
H558_RS08105	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H558_RS08110	COG2223	nitrite transmembrane transporter activity
H558_RS08115	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
H558_RS08130	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H558_RS08135	COG0708	Exodeoxyribonuclease III
H558_RS08140	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
H558_RS08145	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H558_RS08150	COG0154	amidase activity
H558_RS08155	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H558_RS08160	COG1077	Cell shape determining protein MreB Mrl
H558_RS08165	COG1792	Involved in formation and maintenance of cell shape
H558_RS08175	COG0768	penicillin binding
H558_RS08180	COG0772	Belongs to the SEDS family
H558_RS08185	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
H558_RS08190	COG0471	metal ion transport
H558_RS08195	COG1309	transcriptional regulator
H558_RS08205	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H558_RS08220	COG2823	Periplasmic or secreted lipoprotein
H558_RS08225	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
H558_RS08230	COG0792	nuclease activity
H558_RS08250	COG1660	Displays ATPase and GTPase activities
H558_RS08265	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
H558_RS08275	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
H558_RS08285	COG3181	Tripartite tricarboxylate transporter family receptor
H558_RS08290	COG1473	amidohydrolase
H558_RS08295	COG1137	ATPase activity
H558_RS08310	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
H558_RS08320	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
H558_RS08340	COG1294	oxidase, subunit
H558_RS08350	COG4988	ABC transporter
H558_RS08355	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
H558_RS08360	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H558_RS08375	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H558_RS08380	COG1238	metal cluster binding
H558_RS08390	COG1802	Transcriptional regulator
H558_RS08400	COG1984	allophanate hydrolase subunit 2
H558_RS08405	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
H558_RS08415	COG0583	DNA-binding transcription factor activity
H558_RS08420	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H558_RS08425	COG5002	protein histidine kinase activity
H558_RS08430	COG0745	RESPONSE REGULATOR receiver
H558_RS08435	COG2226	methyltransferase
H558_RS08470	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H558_RS08480	COG1028	Short-chain dehydrogenase reductase Sdr
H558_RS08500	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H558_RS08505	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H558_RS08515	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
H558_RS08525	COG2801	Transposase and inactivated derivatives
H558_RS08535	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
H558_RS08540	COG1538	Outer membrane efflux protein
H558_RS08550	COG0351	phosphomethylpyrimidine kinase
H558_RS08555	COG2022	thiamine diphosphate biosynthetic process
H558_RS08560	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H558_RS08580	COG2226	methyltransferase
H558_RS08590	COG1194	a g-specific adenine glycosylase
H558_RS08600	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
H558_RS08605	COG2177	Part of the ABC transporter FtsEX involved in
H558_RS08610	COG2884	Cell division ATP-binding protein ftsE
H558_RS08615	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H558_RS08620	COG4597	amino acid ABC transporter
H558_RS08625	COG0765	amino acid transport
H558_RS08630	COG1126	abc transporter atp-binding protein
H558_RS08660	COG0477	Major facilitator Superfamily
H558_RS08670	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
H558_RS08675	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
H558_RS08685	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
H558_RS08690	COG0237	dephospho-CoA kinase activity
H558_RS08695	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
H558_RS08705	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H558_RS08720	COG3539	Fimbrial protein
H558_RS08725	COG3539	Fimbrial protein
H558_RS08745	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
H558_RS08755	COG1846	Transcriptional regulator
H558_RS08820	COG1028	Short-chain dehydrogenase reductase Sdr
H558_RS08825	COG1024	Enoyl-CoA hydratase
H558_RS08830	COG1960	acyl-CoA dehydrogenase activity
H558_RS08860	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H558_RS08865	COG0352	thiamine-phosphate diphosphorylase activity
H558_RS08870	COG0351	phosphomethylpyrimidine kinase
H558_RS08875	COG1678	Uncharacterized ACR, COG1678
H558_RS08880	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H558_RS08905	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H558_RS08915	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H558_RS08920	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H558_RS08930	COG0557	exoribonuclease II activity
H558_RS08940	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H558_RS08945	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H558_RS08950	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
H558_RS08960	COG0439	Biotin carboxylase
H558_RS08965	COG2264	protein methyltransferase activity
H558_RS08975	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H558_RS08995	COG1696	Membrane protein involved in D-alanine export
H558_RS09000	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
H558_RS09045	COG1522	sequence-specific DNA binding
H558_RS09060	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H558_RS09120	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H558_RS09145	COG3028	Belongs to the UPF0307 family
H558_RS09150	COG0312	modulator of DNA gyrase
H558_RS09155	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H558_RS09160	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H558_RS09165	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
H558_RS09175	COG0316	Belongs to the HesB IscA family
H558_RS09185	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
H558_RS09195	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H558_RS09200	COG1881	PFAM PEBP family protein
H558_RS09205	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H558_RS09210	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H558_RS09225	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H558_RS09225	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H558_RS09240	COG2718	Belongs to the UPF0229 family
H558_RS09245	COG2719	SpoVR family
H558_RS09290	COG0477	Major facilitator Superfamily
H558_RS09305	COG0165	Argininosuccinate lyase
H558_RS09310	COG0589	response to stress
H558_RS09320	COG2816	NAD+ diphosphatase activity
H558_RS09325	COG4993	Dehydrogenase
H558_RS09350	COG3181	Tripartite tricarboxylate transporter family receptor
H558_RS09355	COG2979	Protein of unknown function (DUF533)
H558_RS09360	COG4206	TonB-dependent receptor
H558_RS09375	COG1388	LysM domain
H558_RS09375	COG0741	lytic transglycosylase activity
H558_RS09380	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H558_RS09385	COG2226	methyltransferase
H558_RS09390	COG0328	RNA-DNA hybrid ribonuclease activity
H558_RS09415	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H558_RS09430	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H558_RS09435	COG0842	Transport permease protein
H558_RS09435	COG1129	ABC transporter
H558_RS09440	COG0842	Transport permease protein
H558_RS09455	COG0463	Glycosyl transferase, family 2
H558_RS09460	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
H558_RS09470	COG1073	alpha beta
H558_RS09480	COG0697	spore germination
H558_RS09485	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H558_RS09505	COG2801	Transposase and inactivated derivatives
H558_RS09510	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H558_RS09540	COG0823	Involved in the tonB-independent uptake of proteins
H558_RS09550	COG0848	biopolymer transport protein
H558_RS09555	COG0811	peptide transport
H558_RS09560	COG0824	Thioesterase
H558_RS09565	COG0442	prolyl-tRNA aminoacylation
H558_RS09605	COG2084	Dehydrogenase
H558_RS09645	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
H558_RS09650	COG4654	Cytochrome c, class I
H558_RS09655	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H558_RS09705	COG2801	Transposase and inactivated derivatives
H558_RS09720	COG1473	amidohydrolase
H558_RS09725	COG0418	dihydroorotase activity
H558_RS09730	COG0488	(ABC) transporter
H558_RS09740	COG2001	Belongs to the MraZ family
H558_RS09745	COG0275	rRNA processing
H558_RS09750	COG3116	cell division
H558_RS09760	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H558_RS09765	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H558_RS09770	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H558_RS09780	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H558_RS09785	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H558_RS09790	COG1181	Belongs to the D-alanine--D-alanine ligase family
H558_RS09795	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H558_RS09810	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
H558_RS09825	COG0739	heme binding
H558_RS09830	COG0653	protein targeting
H558_RS09845	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
H558_RS09850	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H558_RS09860	COG0828	Belongs to the bacterial ribosomal protein bS21 family
H558_RS09885	COG2801	Transposase and inactivated derivatives
H558_RS09895	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
H558_RS09910	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
H558_RS09930	COG0583	DNA-binding transcription factor activity
H558_RS09940	COG3181	Tripartite tricarboxylate transporter family receptor
H558_RS09945	COG2084	Dehydrogenase
H558_RS09955	COG1803	Methylglyoxal synthase
H558_RS09955	COG1597	lipid kinase activity
H558_RS09965	COG0671	phosphoesterase, PA-phosphatase related
H558_RS09985	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
H558_RS09990	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H558_RS09995	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H558_RS10000	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H558_RS10005	COG0649	NAD binding
H558_RS10010	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
H558_RS10020	COG1034	ATP synthesis coupled electron transport
H558_RS10025	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
H558_RS10030	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H558_RS10040	COG0713	ATP synthesis coupled electron transport
H558_RS10055	COG1007	ATP synthesis coupled electron transport
H558_RS10065	COG0560	Phosphoserine phosphatase
H558_RS10070	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H558_RS10075	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
H558_RS10080	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
H558_RS10095	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H558_RS10100	COG0450	alkyl hydroperoxide reductase
H558_RS10120	COG1214	PFAM Peptidase M22, glycoprotease
H558_RS10125	COG1573	uracil-dna glycosylase
H558_RS10130	COG0477	Major facilitator Superfamily
H558_RS10135	COG1196	nuclear chromosome segregation
H558_RS10145	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H558_RS10150	COG1126	abc transporter atp-binding protein
H558_RS10155	COG0765	amino acid transport
H558_RS10160	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H558_RS10165	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H558_RS10170	COG2917	probably involved in intracellular septation
H558_RS10175	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H558_RS10180	COG1122	ATPase activity
H558_RS10185	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
H558_RS10190	COG1268	BioY protein
H558_RS10220	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H558_RS10240	COG2801	Transposase and inactivated derivatives
H558_RS10245	COG2801	Transposase and inactivated derivatives
H558_RS10255	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H558_RS10260	COG2878	Part of a membrane complex involved in electron transport
H558_RS10280	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
H558_RS10285	COG0251	oxidation-reduction process
H558_RS10295	COG3228	Belongs to the MtfA family
H558_RS10300	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H558_RS10310	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H558_RS10320	COG0159	tryptophan synthase activity
H558_RS10325	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H558_RS10330	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
H558_RS10340	COG2801	Transposase and inactivated derivatives
H558_RS10345	COG2801	Transposase and inactivated derivatives
H558_RS10350	COG1530	ribonuclease E activity
H558_RS10355	COG0564	pseudouridine synthase activity
H558_RS10360	COG0546	phosphoglycolate phosphatase activity
H558_RS10365	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
H558_RS10370	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
H558_RS10375	COG3023	N-Acetylmuramoyl-L-alanine amidase
H558_RS10385	COG0424	maF-like protein
H558_RS10395	COG0333	Belongs to the bacterial ribosomal protein bL32 family
H558_RS10405	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H558_RS10415	COG1028	Short-chain dehydrogenase reductase Sdr
H558_RS10420	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H558_RS10425	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H558_RS10465	COG2801	Transposase and inactivated derivatives
H558_RS10480	COG0481	GTPase activity
H558_RS10485	COG0681	Belongs to the peptidase S26 family
H558_RS10490	COG0571	ribonuclease III activity
H558_RS10495	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H558_RS10500	COG1381	Involved in DNA repair and RecF pathway recombination
H558_RS10515	COG0670	Belongs to the BI1 family
H558_RS10530	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H558_RS10555	COG0583	DNA-binding transcription factor activity
H558_RS10570	COG0791	NLP P60 protein
H558_RS10575	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H558_RS10580	COG3193	protein, possibly involved in utilization of glycolate and propanediol
H558_RS10590	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H558_RS10605	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
H558_RS10640	COG1446	asparaginase
H558_RS10645	COG4172	Belongs to the ABC transporter superfamily
H558_RS10650	COG0747	negative chemotaxis
H558_RS10655	COG0601	transmembrane transport
H558_RS10680	COG0504	CTP synthase activity
H558_RS10690	COG0148	phosphopyruvate hydratase activity
H558_RS10705	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
H558_RS10715	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H558_RS10720	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H558_RS10735	COG2801	Transposase and inactivated derivatives
H558_RS10760	COG1981	membrane
H558_RS10780	COG0039	L-malate dehydrogenase activity
H558_RS10785	COG2188	Transcriptional regulator
H558_RS10790	COG2009	succinate dehydrogenase
H558_RS10795	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
H558_RS10800	COG1053	succinate dehydrogenase
H558_RS10805	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H558_RS10810	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
H558_RS10815	COG0372	Belongs to the citrate synthase family
H558_RS10825	COG0583	DNA-binding transcription factor activity
H558_RS10830	COG3842	ATPase activity
H558_RS10840	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H558_RS10845	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H558_RS10855	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H558_RS10865	COG3128	pkhd-type hydroxylase
H558_RS10870	COG4774	siderophore transport
H558_RS10880	COG0281	malic enzyme
H558_RS10880	COG0280	phosphate acetyltransferase
H558_RS10890	COG1297	OPT oligopeptide transporter protein
H558_RS10895	COG0567	Dehydrogenase, E1 component
H558_RS10900	COG0508	dehydrogenase complex catalyzes the overall conversion of
H558_RS10905	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H558_RS10910	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
H558_RS10915	COG1595	DNA-templated transcription, initiation
H558_RS10925	COG4774	siderophore transport
H558_RS10945	COG2183	response to ionizing radiation
H558_RS10950	COG1199	ATP-dependent helicase activity
H558_RS10960	COG0564	pseudouridine synthase activity
H558_RS10970	COG3243	poly(R)-hydroxyalkanoic acid synthase
H558_RS10975	COG1028	Short-chain dehydrogenase reductase Sdr
H558_RS10980	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
H558_RS10995	COG0672	)-iron permease
H558_RS11010	COG2823	Periplasmic or secreted lipoprotein
H558_RS11020	COG3237	CsbD-like
H558_RS11025	COG3038	cytochrome b561
H558_RS11040	COG1132	(ABC) transporter
H558_RS11055	COG2833	Protein of unknown function (DUF455)
H558_RS11060	COG2951	lytic endotransglycosylase activity
H558_RS11085	COG0586	Pfam SNARE associated Golgi protein
H558_RS11120	COG2801	Transposase and inactivated derivatives
H558_RS11140	COG0165	Argininosuccinate lyase
H558_RS11160	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H558_RS11175	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
H558_RS11180	COG1605	Chorismate mutase
H558_RS11180	COG0077	Prephenate dehydratase
H558_RS11185	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H558_RS11195	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H558_RS11200	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
H558_RS11220	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
H558_RS11225	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
H558_RS11230	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H558_RS11235	COG0587	DNA-directed DNA polymerase activity
H558_RS11245	COG2951	lytic endotransglycosylase activity
H558_RS11250	COG0123	including yeast histone deacetylase and acetoin utilization protein
H558_RS11265	COG2985	domain, Protein
H558_RS11270	COG1960	acyl-CoA dehydrogenase activity
H558_RS11275	COG0450	alkyl hydroperoxide reductase
H558_RS11280	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
H558_RS11285	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
H558_RS11290	COG4208	sulfate ABC transporter
H558_RS11295	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
H558_RS11300	COG0175	sulfate reduction
H558_RS11325	COG0335	large ribosomal subunit rRNA binding
H558_RS11340	COG3622	Belongs to the hyi family
H558_RS11345	COG1162	GTPase activity
H558_RS11350	COG0501	Belongs to the peptidase M48B family
H558_RS11355	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
H558_RS11360	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H558_RS11365	COG3327	negative regulation of DNA-templated transcription, initiation
H558_RS11370	COG3396	Phenylacetate-CoA oxygenase
H558_RS11375	COG3460	Phenylacetate-CoA oxygenase
H558_RS11380	COG3396	Phenylacetate-CoA oxygenase
H558_RS11385	COG2151	metal-sulfur cluster biosynthetic enzyme
H558_RS11390	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H558_RS11395	COG1012	belongs to the aldehyde dehydrogenase family
H558_RS11400	COG1024	Enoyl-CoA hydratase
H558_RS11405	COG2050	protein possibly involved in aromatic compounds catabolism
H558_RS11435	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
H558_RS11435	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
H558_RS11445	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H558_RS11450	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
H558_RS11455	COG2346	COG2346, Truncated hemoglobins
H558_RS11460	COG3642	lipopolysaccharide core region biosynthetic process
H558_RS11470	COG3842	ATPase activity
H558_RS11475	COG1176	ABC-type spermidine putrescine transport system, permease component I
H558_RS11480	COG1177	transmembrane transport
H558_RS11500	COG1322	Protein conserved in bacteria
H558_RS11510	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
H558_RS11515	COG0704	Plays a role in the regulation of phosphate uptake
H558_RS11520	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
H558_RS11525	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H558_RS11525	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
H558_RS11530	COG1643	Atp-dependent helicase
H558_RS11545	COG0438	transferase activity, transferring glycosyl groups
H558_RS11550	COG0726	polysaccharide deacetylase
H558_RS11555	COG0463	Glycosyl transferase, family 2
H558_RS11585	COG1132	(ABC) transporter
H558_RS11610	COG0501	Belongs to the peptidase M48B family
H558_RS11655	COG1722	exodeoxyribonuclease VII activity
H558_RS11660	COG0142	geranyltranstransferase activity
H558_RS11665	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H558_RS11670	COG1469	GTP cyclohydrolase I activity
H558_RS11675	COG0360	Binds together with S18 to 16S ribosomal RNA
H558_RS11680	COG2965	DNA replication, synthesis of RNA primer
H558_RS11685	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
H558_RS11690	COG0359	binds to the 23S rRNA
H558_RS11700	COG0305	Participates in initiation and elongation during chromosome replication
H558_RS11710	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H558_RS11715	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
H558_RS11720	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H558_RS11725	COG3737	Protein of unknown function (DUF498/DUF598)
H558_RS11730	COG0436	Aminotransferase
H558_RS11750	COG2801	Transposase and inactivated derivatives
H558_RS11755	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
H558_RS11760	COG0308	aminopeptidase N
H558_RS11775	COG0312	modulator of DNA gyrase
H558_RS11780	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H558_RS11795	COG2801	Transposase and inactivated derivatives
H558_RS11805	COG0277	FAD linked oxidase domain protein
H558_RS11810	COG0277	FAD linked oxidase domain protein
H558_RS11815	COG0247	lactate metabolic process
H558_RS11850	COG0583	DNA-binding transcription factor activity
H558_RS11855	COG0482	sulfurtransferase activity
H558_RS11860	COG0730	response to heat
H558_RS11865	COG0625	glutathione transferase activity
H558_RS11870	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H558_RS11875	COG3909	cytochrome
H558_RS11890	COG2801	Transposase and inactivated derivatives
H558_RS11915	COG3706	GGDEF domain
H558_RS11925	COG2801	Transposase and inactivated derivatives
H558_RS11935	COG2826	transposase and inactivated derivatives, IS30 family
H558_RS11955	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
H558_RS11975	COG0069	glutamate synthase activity
H558_RS11980	COG2391	methyltransferase activity
H558_RS11985	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
H558_RS11990	COG0679	Auxin Efflux Carrier
H558_RS11995	COG2153	protein acetylation
H558_RS12015	COG0557	exoribonuclease II activity
H558_RS12020	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H558_RS12025	COG2873	o-acetylhomoserine
H558_RS12030	COG0776	regulation of translation
H558_RS12060	COG0642	Histidine kinase
H558_RS12065	COG3158	transport of potassium into the cell
H558_RS12085	COG2801	Transposase and inactivated derivatives
H558_RS12090	COG0137	argininosuccinate synthase activity
H558_RS12095	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H558_RS12100	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H558_RS12110	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H558_RS12125	COG2186	Transcriptional regulator
H558_RS12160	COG3836	Belongs to the HpcH HpaI aldolase family
H558_RS12165	COG0268	Binds directly to 16S ribosomal RNA
H558_RS12185	COG2801	Transposase and inactivated derivatives
H558_RS12190	COG2801	Transposase and inactivated derivatives
H558_RS12220	COG0728	peptidoglycan biosynthetic process
H558_RS12230	COG0563	adenylate kinase activity
H558_RS12235	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
H558_RS12240	COG2835	tetraacyldisaccharide 4'-kinase activity
H558_RS12245	COG1663	tetraacyldisaccharide 4'-kinase activity
H558_RS12250	COG0848	biopolymer transport protein
H558_RS12255	COG0811	peptide transport
H558_RS12260	COG1570	exodeoxyribonuclease VII activity
H558_RS12265	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H558_RS12270	COG2801	Transposase and inactivated derivatives
H558_RS12280	COG0038	chloride channel
H558_RS12285	COG0183	Belongs to the thiolase family
H558_RS12295	COG1278	Cold shock
H558_RS12300	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H558_RS12315	COG4953	penicillin-binding protein 1C
H558_RS12330	COG3008	intermembrane lipid transfer
H558_RS12340	COG0506	proline dehydrogenase activity
H558_RS12340	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
H558_RS12340	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
H558_RS12375	COG0004	ammonium transporteR
H558_RS12380	COG0347	Belongs to the P(II) protein family
H558_RS12410	COG0291	Belongs to the bacterial ribosomal protein bL35 family
H558_RS12415	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
H558_RS12420	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H558_RS12425	COG0072	phenylalanine-tRNA ligase activity
H558_RS12425	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H558_RS12430	COG0776	regulation of translation
H558_RS12460	COG1802	Transcriptional regulator
H558_RS12465	COG3181	Tripartite tricarboxylate transporter family receptor
H558_RS12475	COG0473	3-isopropylmalate dehydrogenase activity
H558_RS12490	COG1278	Cold shock
H558_RS12500	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
H558_RS12520	COG1522	sequence-specific DNA binding
H558_RS12570	COG5265	(ABC) transporter
H558_RS12575	COG0656	L-ascorbic acid biosynthetic process
H558_RS12585	COG2801	Transposase and inactivated derivatives
H558_RS12590	COG0656	L-ascorbic acid biosynthetic process
H558_RS12595	COG0667	Aldo Keto reductase
H558_RS12610	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H558_RS12645	COG1610	YqeY-like protein
H558_RS12660	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H558_RS12665	COG3246	L-lysine catabolic process to acetate
H558_RS12670	COG1250	3-hydroxyacyl-CoA dehydrogenase
H558_RS12680	COG0318	PFAM AMP-dependent synthetase and ligase
H558_RS12695	COG0183	Belongs to the thiolase family
H558_RS12700	COG1024	Enoyl-CoA hydratase
H558_RS12700	COG1250	3-hydroxyacyl-CoA dehydrogenase
H558_RS12710	COG1024	Enoyl-CoA hydratase
H558_RS12710	COG1250	3-hydroxyacyl-CoA dehydrogenase
H558_RS12715	COG0183	Belongs to the thiolase family
H558_RS12720	COG1960	acyl-CoA dehydrogenase activity
H558_RS12730	COG1045	serine acetyltransferase
H558_RS12740	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H558_RS12745	COG0483	inositol monophosphate 1-phosphatase activity
H558_RS12750	COG1012	belongs to the aldehyde dehydrogenase family
H558_RS12755	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
H558_RS12770	COG0210	DNA helicase
H558_RS12775	COG0598	Magnesium transport protein CorA
H558_RS12785	COG0747	negative chemotaxis
H558_RS12790	COG0601	transmembrane transport
H558_RS12795	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H558_RS12800	COG4172	Belongs to the ABC transporter superfamily
H558_RS12820	COG1346	cytolysis
H558_RS12830	COG1028	Short-chain dehydrogenase reductase Sdr
H558_RS12835	COG0783	Belongs to the Dps family
H558_RS12855	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
H558_RS12865	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H558_RS12870	COG1845	cytochrome c oxidase, subunit III
H558_RS12875	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
H558_RS12890	COG2801	Transposase and inactivated derivatives
H558_RS12895	COG2801	Transposase and inactivated derivatives
H558_RS12925	COG1666	GTP binding
H558_RS12950	COG1028	Short-chain dehydrogenase reductase Sdr
H558_RS12955	COG5006	permease, DMT superfamily
H558_RS12980	COG2264	protein methyltransferase activity
H558_RS13015	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H558_RS13020	COG0746	molybdenum cofactor guanylyltransferase activity
H558_RS13025	COG0303	'Molybdopterin
H558_RS13030	COG0521	Mo-molybdopterin cofactor biosynthetic process
H558_RS13035	COG0314	molybdopterin synthase activity
H558_RS13045	COG0315	cyclic pyranopterin monophosphate synthase activity
H558_RS13050	COG0412	Dienelactone hydrolase
H558_RS13060	COG0678	peroxiredoxin activity
H558_RS13075	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H558_RS13085	COG0542	response to heat
H558_RS13095	COG1477	protein flavinylation
H558_RS13120	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H558_RS13125	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
H558_RS13125	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
H558_RS13130	COG1562	ergosterol biosynthetic process
H558_RS13135	COG1562	ergosterol biosynthetic process
H558_RS13140	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H558_RS13145	COG1028	Short-chain dehydrogenase reductase Sdr
H558_RS13180	COG0254	rRNA binding
H558_RS13185	COG3483	tryptophan 2,3-dioxygenase activity
H558_RS13190	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
H558_RS13195	COG2003	Belongs to the UPF0758 family
H558_RS13205	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
H558_RS13210	COG0625	glutathione transferase activity
H558_RS13240	COG0583	DNA-binding transcription factor activity
H558_RS13250	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
H558_RS13255	COG1187	pseudouridine synthase activity
H558_RS13260	COG0779	Required for maturation of 30S ribosomal subunits
H558_RS13265	COG0195	Participates in both transcription termination and antitermination
H558_RS13265	COG2251	uridine kinase activity
H558_RS13270	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
H558_RS13275	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H558_RS13280	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
H558_RS13285	COG1217	gtp-binding protein TYPA
H558_RS13300	COG1802	Transcriptional regulator
H558_RS13310	COG1024	Enoyl-CoA hydratase
H558_RS13315	COG0318	PFAM AMP-dependent synthetase and ligase
H558_RS13325	COG2032	superoxide dismutase activity
H558_RS13340	COG4120	Belongs to the binding-protein-dependent transport system permease family
H558_RS13345	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
H558_RS13350	COG0725	ABC transporter, periplasmic molybdate-binding protein
H558_RS13355	COG4149	molybdate abc transporter
H558_RS13385	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H558_RS13390	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H558_RS13395	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H558_RS13405	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
H558_RS13410	COG0736	holo-[acyl-carrier-protein] synthase activity
H558_RS13415	COG1472	Belongs to the glycosyl hydrolase 3 family
H558_RS13420	COG0322	excinuclease ABC activity
H558_RS13425	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H558_RS13435	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H558_RS13435	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H558_RS13440	COG2224	Isocitrate lyase
H558_RS13445	COG1846	Transcriptional regulator
H558_RS13450	COG1764	response to oxidative stress
H558_RS13455	COG1131	(ABC) transporter
H558_RS13460	COG0842	Transport permease protein
H558_RS13465	COG0628	permease
H558_RS13480	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
H558_RS13490	COG2814	Major facilitator Superfamily
H558_RS13510	COG3015	lipoprotein NlpE involved in copper resistance
H558_RS13520	COG3530	Putative quorum-sensing-regulated virulence factor
H558_RS13535	COG0494	nUDIX hydrolase
H558_RS13545	COG0697	spore germination
H558_RS13550	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
H558_RS13575	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H558_RS13580	COG1702	phosphate starvation-inducible protein PhoH
H558_RS13585	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H558_RS13590	COG4535	Mg2 and Co2 transporter CorC
H558_RS13595	COG0815	Transfers the fatty acyl group on membrane lipoproteins
H558_RS13600	COG0667	Aldo Keto reductase
H558_RS13620	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H558_RS13625	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H558_RS13630	COG1862	Preprotein translocase
H558_RS13635	COG0343	queuine tRNA-ribosyltransferase activity
H558_RS13640	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H558_RS13645	COG2027	D-alanyl-D-alanine carboxypeptidase
H558_RS13650	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
H558_RS13655	COG1648	precorrin-2 dehydrogenase activity
H558_RS13655	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H558_RS13665	COG4575	ribosome binding
H558_RS13685	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
H558_RS13690	COG0741	lytic transglycosylase activity
H558_RS13695	COG0436	Aminotransferase
H558_RS13705	COG0280	phosphate acetyltransferase
H558_RS13705	COG0281	malic enzyme
H558_RS13720	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H558_RS13725	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H558_RS13730	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H558_RS13735	COG0126	phosphoglycerate kinase activity
H558_RS13755	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
H558_RS13770	COG0625	glutathione transferase activity
H558_RS13790	COG0789	Transcriptional regulator
H558_RS13805	COG0306	phosphate transporter
H558_RS13810	COG0521	Mo-molybdopterin cofactor biosynthetic process
H558_RS13820	COG0739	heme binding
H558_RS13830	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
H558_RS13850	COG2801	Transposase and inactivated derivatives
H558_RS13855	COG2801	Transposase and inactivated derivatives
H558_RS13875	COG0456	acetyltransferase
H558_RS13880	COG1301	dicarboxylic acid transport
H558_RS13890	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H558_RS13895	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
H558_RS13900	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
H558_RS13905	COG0009	L-threonylcarbamoyladenylate synthase
H558_RS13915	COG4771	TonB-dependent receptor
H558_RS13945	COG1960	acyl-CoA dehydrogenase activity
H558_RS13950	COG0028	Belongs to the TPP enzyme family
H558_RS13955	COG0583	DNA-binding transcription factor activity
H558_RS13960	COG4974	Belongs to the 'phage' integrase family
H558_RS13965	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H558_RS13970	COG1686	Belongs to the peptidase S11 family
H558_RS14000	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H558_RS14005	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
H558_RS14010	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H558_RS14030	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H558_RS14035	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H558_RS14040	COG0505	Belongs to the CarA family
H558_RS14045	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H558_RS14055	COG1028	Short-chain dehydrogenase reductase Sdr
H558_RS14060	COG0406	alpha-ribazole phosphatase activity
H558_RS14090	COG2233	PERMEase
H558_RS14095	COG3620	sequence-specific DNA binding
H558_RS14105	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H558_RS14115	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
H558_RS14120	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H558_RS14130	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H558_RS14145	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
H558_RS14160	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H558_RS14175	COG2963	transposase activity
H558_RS14180	COG2801	Transposase and inactivated derivatives
H558_RS14210	COG2801	Transposase and inactivated derivatives
H558_RS14230	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H558_RS14265	COG0540	Belongs to the ATCase OTCase family
H558_RS14270	COG2974	May be involved in recombination
H558_RS14295	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H558_RS14300	COG2137	regulation of response to DNA damage stimulus
H558_RS14310	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
H558_RS14325	COG0045	succinate-CoA ligase (ADP-forming) activity
H558_RS14330	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
H558_RS14335	COG0861	Integral membrane protein TerC family
H558_RS14340	COG0861	Integral membrane protein TerC family
H558_RS14345	COG0181	hydroxymethylbilane synthase activity
H558_RS14385	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H558_RS14430	COG1450	Type ii and iii secretion system protein
H558_RS14445	COG2801	Transposase and inactivated derivatives
H558_RS14475	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H558_RS14485	COG1295	ribonuclease BN
H558_RS14495	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
H558_RS14515	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
H558_RS14520	COG0501	Belongs to the peptidase M48B family
H558_RS14525	COG2197	response regulator
H558_RS14530	COG2801	Transposase and inactivated derivatives
H558_RS14535	COG2801	Transposase and inactivated derivatives
H558_RS14555	COG0066	3-isopropylmalate dehydratase activity
H558_RS14565	COG0473	3-isopropylmalate dehydrogenase activity
H558_RS14570	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H558_RS14580	COG0101	tRNA pseudouridine synthase activity
H558_RS14585	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
H558_RS14590	COG0135	phosphoribosylanthranilate isomerase activity
H558_RS14600	COG2801	Transposase and inactivated derivatives
H558_RS14605	COG2963	transposase activity
H558_RS14610	COG2801	Transposase and inactivated derivatives
H558_RS14630	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H558_RS14635	COG2197	response regulator
H558_RS14640	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H558_RS14645	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
H558_RS14660	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H558_RS14665	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H558_RS14675	COG1764	response to oxidative stress
H558_RS14690	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H558_RS14695	COG0765	amino acid transport
H558_RS14700	COG0765	amino acid transport
H558_RS14710	COG0756	dUTP diphosphatase activity
H558_RS14740	COG1522	sequence-specific DNA binding
H558_RS14755	COG2801	Transposase and inactivated derivatives
H558_RS14760	COG2801	Transposase and inactivated derivatives
H558_RS14765	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H558_RS14770	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
H558_RS14775	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H558_RS14780	COG0196	riboflavin kinase activity
H558_RS14790	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H558_RS14790	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H558_RS14800	COG2801	Transposase and inactivated derivatives
H558_RS14810	COG0210	DNA helicase
H558_RS14815	COG4771	TonB-dependent receptor
H558_RS14820	COG0488	(ABC) transporter
H558_RS14825	COG2890	protein-(glutamine-N5) methyltransferase activity
H558_RS14830	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H558_RS14835	COG2171	N-acyltransferase activity
H558_RS14885	COG2801	Transposase and inactivated derivatives
H558_RS14905	COG2801	Transposase and inactivated derivatives
H558_RS14930	COG2814	Major facilitator Superfamily
H558_RS14955	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H558_RS14960	COG2900	Belongs to the SlyX family
H558_RS14975	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H558_RS14995	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H558_RS15020	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H558_RS15025	COG0583	DNA-binding transcription factor activity
H558_RS15030	COG1028	Short-chain dehydrogenase reductase Sdr
H558_RS15040	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
H558_RS15045	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
H558_RS15055	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H558_RS15060	COG0508	dehydrogenase complex catalyzes the overall conversion of
H558_RS15065	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
H558_RS15075	COG4566	intracellular signal transduction
H558_RS15080	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H558_RS15100	COG1999	signal sequence binding
H558_RS15120	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H558_RS15125	COG0583	DNA-binding transcription factor activity
H558_RS15130	COG1187	pseudouridine synthase activity
H558_RS15135	COG3161	chorismate lyase activity
H558_RS15150	COG1280	lysine exporter protein (LysE YggA)
H558_RS15195	COG0583	DNA-binding transcription factor activity
H558_RS15205	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H558_RS15225	COG1185	polyribonucleotide nucleotidyltransferase activity
H558_RS15230	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H558_RS15245	COG1183	phosphatidylcholine synthase activity
H558_RS15255	COG0440	acetolactate synthase activity
H558_RS15260	COG0028	Belongs to the TPP enzyme family
H558_RS15285	COG3022	response to hydroperoxide
H558_RS15295	COG1028	Short-chain dehydrogenase reductase Sdr
H558_RS15310	COG3486	L-lysine 6-monooxygenase (NADPH) activity
H558_RS15340	COG2814	Major facilitator Superfamily
H558_RS15360	COG2801	Transposase and inactivated derivatives
H558_RS15365	COG2801	Transposase and inactivated derivatives
H558_RS15380	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H558_RS15415	COG2733	membrane
H558_RS15435	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
H558_RS15455	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H558_RS15460	COG0842	Transport permease protein
H558_RS15460	COG1129	ABC transporter
H558_RS15465	COG0842	Transport permease protein
H558_RS15475	COG1028	Short-chain dehydrogenase reductase Sdr
H558_RS15485	COG2259	Doxx family
H558_RS15515	COG0415	Belongs to the DNA photolyase family
H558_RS15535	COG0386	Belongs to the glutathione peroxidase family
H558_RS15550	COG0095	Lipoate-protein ligase
H558_RS15560	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
H558_RS15570	COG0010	Belongs to the arginase family
H558_RS15580	COG0765	amino acid transport
H558_RS15585	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H558_RS15600	COG0084	hydrolase, TatD family'
H558_RS15610	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
H558_RS15615	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H558_RS15625	COG2175	clavaminate synthase activity
H558_RS15630	COG0583	DNA-binding transcription factor activity
H558_RS15655	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
H558_RS15660	COG1960	acyl-CoA dehydrogenase activity
H558_RS15670	COG2914	Belongs to the UPF0125 (RnfH) family
H558_RS15680	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
H558_RS15715	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H558_RS15715	COG0519	Catalyzes the synthesis of GMP from XMP
H558_RS15725	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
H558_RS15735	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H558_RS15740	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H558_RS15745	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H558_RS15755	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H558_RS15760	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H558_RS15770	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H558_RS15775	COG0750	zinc metalloprotease
H558_RS15780	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
H558_RS15790	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H558_RS15795	COG0233	cytoplasmic translational termination
H558_RS15800	COG0528	UMP kinase activity
H558_RS15805	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H558_RS15810	COG0052	Belongs to the universal ribosomal protein uS2 family
H558_RS15815	COG0024	Methionine aminopeptidase
H558_RS15820	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
H558_RS15840	COG1286	toxin biosynthetic process
H558_RS15850	COG0285	dihydrofolate synthase activity
H558_RS15860	COG3181	Tripartite tricarboxylate transporter family receptor
H558_RS15865	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H558_RS15885	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
H558_RS15905	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H558_RS15915	COG1677	Flagellar hook-basal body complex protein FliE
H558_RS15925	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H558_RS15930	COG1317	bacterial-type flagellum organization
H558_RS15950	COG1580	Controls the rotational direction of flagella during chemotaxis
H558_RS15960	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H558_RS15985	COG0840	transmembrane signaling receptor activity
H558_RS16010	COG1191	sigma factor activity
H558_RS16020	COG2801	Transposase and inactivated derivatives
H558_RS16025	COG2801	Transposase and inactivated derivatives
H558_RS16050	COG2199	diguanylate cyclase activity
H558_RS16050	COG2203	Gaf domain
H558_RS16060	COG1619	proteins homologs of microcin C7 resistance protein MccF
H558_RS16085	COG1126	abc transporter atp-binding protein
H558_RS16090	COG0765	amino acid transport
H558_RS16095	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H558_RS16140	COG2200	EAL domain
H558_RS16160	COG1253	flavin adenine dinucleotide binding
H558_RS16165	COG3706	GGDEF domain
H558_RS16165	COG5001	Diguanylate cyclase
H558_RS16165	COG2203	Gaf domain
H558_RS16165	COG4251	negative regulation of phosphorylation
H558_RS16170	COG2197	response regulator
H558_RS16175	COG2205	protein histidine kinase activity
H558_RS16175	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H558_RS16195	COG2801	Transposase and inactivated derivatives
H558_RS16200	COG0076	glutamate decarboxylase activity
H558_RS16205	COG2985	domain, Protein
H558_RS16210	COG3189	MarR family transcriptional regulator
H558_RS16220	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H558_RS16230	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
H558_RS16230	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
H558_RS16240	COG0028	Belongs to the TPP enzyme family
H558_RS16250	COG1012	belongs to the aldehyde dehydrogenase family
H558_RS16260	COG0688	phosphatidylethanolamine metabolic process
H558_RS16265	COG1304	FMN binding
H558_RS16270	COG1464	Belongs to the NlpA lipoprotein family
H558_RS16275	COG2801	Transposase and inactivated derivatives
H558_RS16285	COG0697	spore germination
H558_RS16290	COG2133	pyrroloquinoline quinone binding
H558_RS16295	COG0625	glutathione transferase activity
H558_RS16305	COG1794	racemase activity, acting on amino acids and derivatives
H558_RS16325	COG0559	Belongs to the binding-protein-dependent transport system permease family
H558_RS16335	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
H558_RS16350	COG1175	transmembrane transport
H558_RS16355	COG0395	ABC-type sugar transport system, permease component
H558_RS16360	COG3842	ATPase activity
H558_RS16380	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
H558_RS16395	COG0438	transferase activity, transferring glycosyl groups
H558_RS16430	COG0783	Belongs to the Dps family
H558_RS16435	COG0583	DNA-binding transcription factor activity
H558_RS16440	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H558_RS16465	COG1840	ABC-type Fe3 transport system, periplasmic component
H558_RS16475	COG3842	ATPase activity
H558_RS16480	COG1741	Belongs to the pirin family
H558_RS16490	COG0583	DNA-binding transcription factor activity
H558_RS16505	COG0174	glutamine synthetase
H558_RS16510	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H558_RS16515	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H558_RS16525	COG0840	transmembrane signaling receptor activity
H558_RS16535	COG0583	DNA-binding transcription factor activity
H558_RS16540	COG1960	acyl-CoA dehydrogenase activity
H558_RS16545	COG2079	MmgE PrpD family protein
H558_RS16555	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
H558_RS16560	COG1561	YicC-like family, N-terminal region
H558_RS16570	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H558_RS16575	COG0791	NLP P60 protein
H558_RS16580	COG1028	Short-chain dehydrogenase reductase Sdr
H558_RS16585	COG0194	GDP metabolic process
H558_RS16590	COG1758	RNA polymerase activity
H558_RS16595	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H558_RS16600	COG1126	abc transporter atp-binding protein
H558_RS16605	COG0765	amino acid transport
H558_RS16610	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H558_RS16620	COG2831	hemolysin activation secretion protein
H558_RS16630	COG3188	usher protein
H558_RS16635	COG3121	Chaperone
H558_RS16650	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
H558_RS16650	COG3064	Membrane
H558_RS16650	COG3210	domain, Protein
H558_RS16650	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
H558_RS16650	COG3064	Membrane
H558_RS16650	COG3210	domain, Protein
H558_RS16660	COG4181	ATPase activity
H558_RS16670	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H558_RS16675	COG0584	glycerophosphoryl diester phosphodiesterase
H558_RS16680	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
H558_RS16690	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
H558_RS16690	COG0678	peroxiredoxin activity
H558_RS16700	COG2217	Heavy metal translocating P-type atpase
H558_RS16705	COG0789	Transcriptional regulator
H558_RS16710	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H558_RS16720	COG2801	Transposase and inactivated derivatives
H558_RS16745	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H558_RS16755	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
H558_RS16780	COG0583	DNA-binding transcription factor activity
H558_RS16785	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H558_RS16790	COG2252	PERMEase
H558_RS16795	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H558_RS16800	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H558_RS16835	COG0488	(ABC) transporter
H558_RS16840	COG1619	proteins homologs of microcin C7 resistance protein MccF
H558_RS16845	COG0590	tRNA wobble adenosine to inosine editing
H558_RS16860	COG1320	monovalent cation:proton antiporter activity
H558_RS16865	COG2212	antiporter activity
H558_RS16870	COG1863	multisubunit Na H antiporter MnhE subunit
H558_RS16875	COG0651	ATP synthesis coupled electron transport
H558_RS16880	COG1006	Multisubunit Na H antiporter MnhC subunit
H558_RS16885	COG2111	Na H antiporter
H558_RS16885	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H558_RS16890	COG3181	Tripartite tricarboxylate transporter family receptor
H558_RS16910	COG0420	3'-5' exonuclease activity
H558_RS16940	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H558_RS16950	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
H558_RS16960	COG2130	NADP-dependent
H558_RS16965	COG1309	transcriptional regulator
H558_RS16975	COG1131	(ABC) transporter
H558_RS16980	COG0842	Transport permease protein
H558_RS16990	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
H558_RS17025	COG0602	queuosine metabolic process
H558_RS17030	COG0720	synthase
H558_RS17045	COG0840	transmembrane signaling receptor activity
H558_RS17060	COG0587	DNA-directed DNA polymerase activity
H558_RS17070	COG0390	transport system, permease component
H558_RS17075	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H558_RS17080	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
H558_RS17130	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H558_RS17155	COG5507	3-demethylubiquinone-9 3-methyltransferase
H558_RS17190	COG1396	sequence-specific DNA binding
H558_RS17205	COG2801	Transposase and inactivated derivatives
H558_RS17210	COG2801	Transposase and inactivated derivatives
H558_RS17220	COG0583	DNA-binding transcription factor activity
H558_RS17225	COG2814	Major facilitator Superfamily
H558_RS17250	COG2807	transmembrane transport
H558_RS17255	COG2207	Transcriptional regulator
H558_RS17260	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H558_RS17265	COG2814	Major facilitator Superfamily
H558_RS17280	COG1012	belongs to the aldehyde dehydrogenase family
H558_RS17315	COG0583	DNA-binding transcription factor activity
H558_RS17335	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H558_RS17360	COG0384	phenazine biosynthesis protein PhzF
H558_RS17365	COG1733	regulation of RNA biosynthetic process
H558_RS17400	COG3177	Filamentation induced by cAMP protein fic
H558_RS17410	COG0519	Catalyzes the synthesis of GMP from XMP
H558_RS17410	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H558_RS17425	COG1695	Transcriptional regulator
H558_RS17440	COG2072	flavoprotein involved in K transport
H558_RS17445	COG0601	transmembrane transport
H558_RS17460	COG2801	Transposase and inactivated derivatives
H558_RS17465	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H558_RS17475	COG4608	Belongs to the ABC transporter superfamily
H558_RS17480	COG0747	negative chemotaxis
H558_RS17520	COG0047	phosphoribosylformylglycinamidine synthase activity
H558_RS17520	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H558_RS17525	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
H558_RS17530	COG2801	Transposase and inactivated derivatives
H558_RS17540	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
H558_RS17540	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
H558_RS17545	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H558_RS17555	COG0613	PHP domain protein
H558_RS17615	COG1012	belongs to the aldehyde dehydrogenase family
H558_RS17625	COG0583	DNA-binding transcription factor activity
H558_RS17645	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H558_RS17655	COG3181	Tripartite tricarboxylate transporter family receptor
H558_RS17660	COG2963	transposase activity
H558_RS17665	COG3181	Tripartite tricarboxylate transporter family receptor
H558_RS17695	COG1595	DNA-templated transcription, initiation
H558_RS17700	COG3712	iron ion homeostasis
H558_RS17710	COG0084	hydrolase, TatD family'
H558_RS17715	COG1136	(ABC) transporter
H558_RS17730	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H558_RS17735	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
H558_RS17740	COG1028	Short-chain dehydrogenase reductase Sdr
H558_RS17745	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
H558_RS17755	COG1803	Methylglyoxal synthase
H558_RS17775	COG2801	Transposase and inactivated derivatives
H558_RS17790	COG2963	transposase activity
H558_RS17800	COG2975	iron-sulfur cluster assembly
H558_RS17805	COG0633	Ferredoxin
H558_RS17810	COG0443	Heat shock 70 kDa protein
H558_RS17815	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
H558_RS17820	COG0316	Belongs to the HesB IscA family
H558_RS17825	COG0822	iron-sulfur transferase activity
H558_RS17830	COG1104	cysteine desulfurase activity
H558_RS17840	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H558_RS17845	COG0556	nucleotide-excision repair
H558_RS17855	COG2801	Transposase and inactivated derivatives
H558_RS17860	COG0583	DNA-binding transcription factor activity
H558_RS17880	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H558_RS17900	COG2801	Transposase and inactivated derivatives
H558_RS17905	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H558_RS17915	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H558_RS17925	COG0740	serine-type endopeptidase activity
H558_RS17930	COG0544	peptidyl-prolyl cis-trans isomerase activity
H558_RS17960	COG2801	Transposase and inactivated derivatives
H558_RS17970	COG1278	Cold shock
H558_RS18000	COG2433	Pfam Transposase IS66
H558_RS18015	COG2801	Transposase and inactivated derivatives
H558_RS18055	COG2963	transposase activity
H558_RS18060	COG2801	Transposase and inactivated derivatives
H558_RS18065	COG1530	ribonuclease E activity