locus-tag	class	description
CWR58_RS00010	COG0357	Ribosomal RNA small subunit methyltransferase G
CWR58_RS00015	COG1192	Involved in chromosome partitioning
CWR58_RS00025	COG1475	DNA binding
CWR58_RS00030	COG0252	asparaginase activity
CWR58_RS00050	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CWR58_RS00060	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CWR58_RS00075	COG0081	regulation of translation
CWR58_RS00080	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CWR58_RS00085	COG0222	ribosome binding
CWR58_RS00095	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CWR58_RS00130	COG1230	cation diffusion facilitator family transporter
CWR58_RS00140	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CWR58_RS00145	COG0049	tRNA binding
CWR58_RS00155	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CWR58_RS00165	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CWR58_RS00175	COG0089	rRNA binding
CWR58_RS00180	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CWR58_RS00190	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CWR58_RS00195	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CWR58_RS00200	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CWR58_RS00205	COG0255	Belongs to the universal ribosomal protein uL29 family
CWR58_RS00210	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CWR58_RS00230	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CWR58_RS00235	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CWR58_RS00240	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CWR58_RS00245	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CWR58_RS00250	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CWR58_RS00260	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CWR58_RS00265	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CWR58_RS00270	COG1841	ribosomal large subunit assembly
CWR58_RS00280	COG0201	protein transport
CWR58_RS00285	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CWR58_RS00290	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CWR58_RS00295	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CWR58_RS00300	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CWR58_RS00305	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CWR58_RS00310	COG0202	RNA polymerase activity
CWR58_RS00315	COG0203	ribosomal protein L17
CWR58_RS00320	COG0537	adenosine 5'-monophosphoramidase activity
CWR58_RS00325	COG1324	tolerance protein
CWR58_RS00330	COG4232	protein-disulfide reductase activity
CWR58_RS00345	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CWR58_RS00355	COG1333	cytochrome c biogenesis protein
CWR58_RS00360	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CWR58_RS00385	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CWR58_RS00390	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CWR58_RS00410	COG2814	Major facilitator Superfamily
CWR58_RS00455	COG0402	S-adenosylhomocysteine deaminase activity
CWR58_RS00465	COG0438	transferase activity, transferring glycosyl groups
CWR58_RS00485	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CWR58_RS00515	COG2186	Transcriptional regulator
CWR58_RS00535	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CWR58_RS00540	COG1956	GAF domain-containing protein
CWR58_RS00545	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CWR58_RS00575	COG0531	amino acid
CWR58_RS00605	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CWR58_RS00610	COG3568	Endonuclease Exonuclease Phosphatase
CWR58_RS00615	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CWR58_RS00635	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CWR58_RS00645	COG0367	asparagine synthase
CWR58_RS00665	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CWR58_RS00670	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CWR58_RS00710	COG0367	asparagine synthase
CWR58_RS00715	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
CWR58_RS00740	COG0367	asparagine synthase
CWR58_RS00750	COG0438	transferase activity, transferring glycosyl groups
CWR58_RS00770	COG0438	transferase activity, transferring glycosyl groups
CWR58_RS00775	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CWR58_RS00780	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CWR58_RS00810	COG0859	PFAM glycosyl transferase family 9
CWR58_RS00840	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CWR58_RS00845	COG1127	ABC transporter
CWR58_RS00865	COG1686	Belongs to the peptidase S11 family
CWR58_RS00905	COG2096	Adenosyltransferase
CWR58_RS00930	COG0523	cobalamin synthesis protein
CWR58_RS00935	COG0735	belongs to the Fur family
CWR58_RS00940	COG1121	(ABC) transporter
CWR58_RS00950	COG0803	Belongs to the bacterial solute-binding protein 9 family
CWR58_RS00960	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
CWR58_RS00970	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
CWR58_RS00980	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CWR58_RS00985	COG1560	Kdo2-lipid A biosynthetic process
CWR58_RS00995	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CWR58_RS01015	COG1950	PFAM Membrane protein of
CWR58_RS01025	COG0583	DNA-binding transcription factor activity
CWR58_RS01035	COG0477	Major facilitator Superfamily
CWR58_RS01060	COG0513	Belongs to the DEAD box helicase family
CWR58_RS01070	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CWR58_RS01075	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CWR58_RS01090	COG0735	belongs to the Fur family
CWR58_RS01110	COG0438	transferase activity, transferring glycosyl groups
CWR58_RS01135	COG0640	Transcriptional regulator
CWR58_RS01195	COG0583	DNA-binding transcription factor activity
CWR58_RS01210	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CWR58_RS01215	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CWR58_RS01220	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CWR58_RS01235	COG0758	DNA mediated transformation
CWR58_RS01240	COG1522	sequence-specific DNA binding
CWR58_RS01250	COG0242	peptide deformylase activity
CWR58_RS01265	COG0546	phosphoglycolate phosphatase activity
CWR58_RS01285	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CWR58_RS01290	COG1942	4-Oxalocrotonate Tautomerase
CWR58_RS01295	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CWR58_RS01330	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CWR58_RS01330	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CWR58_RS01340	COG5000	phosphorelay sensor kinase activity
CWR58_RS01345	COG2204	response regulator
CWR58_RS01370	COG2068	MobA-Related Protein
CWR58_RS01385	COG0596	Alpha beta hydrolase
CWR58_RS01390	COG2309	aminopeptidase activity
CWR58_RS01395	COG1335	isochorismatase
CWR58_RS01420	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CWR58_RS01445	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
CWR58_RS01450	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CWR58_RS01470	COG2226	methyltransferase
CWR58_RS01485	COG3181	Tripartite tricarboxylate transporter family receptor
CWR58_RS01495	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
CWR58_RS01500	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CWR58_RS01505	COG1054	Belongs to the UPF0176 family
CWR58_RS01515	COG4942	peptidase
CWR58_RS01520	COG0793	Belongs to the peptidase S41A family
CWR58_RS01525	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CWR58_RS01545	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CWR58_RS01580	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CWR58_RS01585	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CWR58_RS01590	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CWR58_RS01600	COG0142	geranyltranstransferase activity
CWR58_RS01610	COG0583	DNA-binding transcription factor activity
CWR58_RS01620	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
CWR58_RS01625	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CWR58_RS01640	COG2994	toxin metabolic process
CWR58_RS01650	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
CWR58_RS01655	COG2274	protein secretion by the type I secretion system
CWR58_RS01660	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CWR58_RS01665	COG1538	Outer membrane efflux protein
CWR58_RS01680	COG0765	amino acid transport
CWR58_RS01685	COG0765	amino acid transport
CWR58_RS01690	COG1126	abc transporter atp-binding protein
CWR58_RS01710	COG1028	Short-chain dehydrogenase reductase Sdr
CWR58_RS01720	COG1802	Transcriptional regulator
CWR58_RS01735	COG1802	Transcriptional regulator
CWR58_RS01745	COG0318	PFAM AMP-dependent synthetase and ligase
CWR58_RS01755	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CWR58_RS01785	COG0583	DNA-binding transcription factor activity
CWR58_RS01790	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CWR58_RS01795	COG2301	Belongs to the HpcH HpaI aldolase family
CWR58_RS01800	COG2188	Transcriptional regulator
CWR58_RS01845	COG0583	DNA-binding transcription factor activity
CWR58_RS01850	COG1024	Enoyl-CoA hydratase
CWR58_RS01885	COG1028	Short-chain dehydrogenase reductase Sdr
CWR58_RS01900	COG1902	pentaerythritol trinitrate reductase activity
CWR58_RS01925	COG0745	RESPONSE REGULATOR receiver
CWR58_RS01965	COG2890	protein-(glutamine-N5) methyltransferase activity
CWR58_RS01970	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CWR58_RS01980	COG3181	Tripartite tricarboxylate transporter family receptor
CWR58_RS02050	COG4211	Belongs to the binding-protein-dependent transport system permease family
CWR58_RS02060	COG0683	leucine binding
CWR58_RS02065	COG0154	amidase activity
CWR58_RS02070	COG0288	reversible hydration of carbon dioxide
CWR58_RS02090	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CWR58_RS02105	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CWR58_RS02115	COG1414	Transcriptional regulator
CWR58_RS02120	COG1028	Short-chain dehydrogenase reductase Sdr
CWR58_RS02125	COG2031	fatty acid transporter
CWR58_RS02130	COG1250	3-hydroxyacyl-CoA dehydrogenase
CWR58_RS02165	COG2808	Putative FMN-binding domain
CWR58_RS02170	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CWR58_RS02175	COG0747	negative chemotaxis
CWR58_RS02180	COG0657	acetylesterase activity
CWR58_RS02190	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CWR58_RS02195	COG2207	Transcriptional regulator
CWR58_RS02220	COG1538	Outer membrane efflux protein
CWR58_RS02235	COG0583	DNA-binding transcription factor activity
CWR58_RS02240	COG0628	permease
CWR58_RS02250	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CWR58_RS02255	COG0251	oxidation-reduction process
CWR58_RS02265	COG0330	HflC and HflK could
CWR58_RS02270	COG3422	double-strand break repair
CWR58_RS02285	COG0583	DNA-binding transcription factor activity
CWR58_RS02320	COG3181	Tripartite tricarboxylate transporter family receptor
CWR58_RS02325	COG0318	PFAM AMP-dependent synthetase and ligase
CWR58_RS02330	COG1414	Transcriptional regulator
CWR58_RS02335	COG1024	Enoyl-CoA hydratase
CWR58_RS02340	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CWR58_RS02345	COG3181	Tripartite tricarboxylate transporter family receptor
CWR58_RS02350	COG0604	alcohol dehydrogenase
CWR58_RS02355	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CWR58_RS02360	COG0583	DNA-binding transcription factor activity
CWR58_RS02370	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CWR58_RS02385	COG0251	oxidation-reduction process
CWR58_RS02395	COG2031	fatty acid transporter
CWR58_RS02425	COG1278	Cold shock
CWR58_RS02430	COG0583	DNA-binding transcription factor activity
CWR58_RS02440	COG3119	arylsulfatase activity
CWR58_RS02455	COG1228	amidohydrolase
CWR58_RS02460	COG0523	cobalamin synthesis protein
CWR58_RS02465	COG1819	glycosyl
CWR58_RS02550	COG0625	glutathione transferase activity
CWR58_RS02565	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CWR58_RS02570	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CWR58_RS02575	COG1652	LysM domain
CWR58_RS02600	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CWR58_RS02605	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CWR58_RS02640	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CWR58_RS02695	COG0583	DNA-binding transcription factor activity
CWR58_RS02700	COG3181	Tripartite tricarboxylate transporter family receptor
CWR58_RS02710	COG1024	Enoyl-CoA hydratase
CWR58_RS02715	COG3181	Tripartite tricarboxylate transporter family receptor
CWR58_RS02740	COG0028	Belongs to the TPP enzyme family
CWR58_RS02750	COG1024	Enoyl-CoA hydratase
CWR58_RS02750	COG1250	3-hydroxyacyl-CoA dehydrogenase
CWR58_RS02755	COG3181	Tripartite tricarboxylate transporter family receptor
CWR58_RS02760	COG1414	Transcriptional regulator
CWR58_RS02780	COG0318	PFAM AMP-dependent synthetase and ligase
CWR58_RS02785	COG1609	Transcriptional regulator
CWR58_RS02815	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CWR58_RS02820	COG1024	Enoyl-CoA hydratase
CWR58_RS02835	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CWR58_RS02840	COG3181	Tripartite tricarboxylate transporter family receptor
CWR58_RS02845	COG0583	DNA-binding transcription factor activity
CWR58_RS02860	COG1960	acyl-CoA dehydrogenase activity
CWR58_RS02875	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CWR58_RS02885	COG3976	FMN-binding domain protein
CWR58_RS02885	COG1053	succinate dehydrogenase
CWR58_RS02920	COG0683	leucine binding
CWR58_RS02930	COG1309	transcriptional regulator
CWR58_RS02950	COG1028	Short-chain dehydrogenase reductase Sdr
CWR58_RS02955	COG1960	acyl-CoA dehydrogenase activity
CWR58_RS02960	COG1028	Short-chain dehydrogenase reductase Sdr
CWR58_RS02965	COG0318	PFAM AMP-dependent synthetase and ligase
CWR58_RS02975	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CWR58_RS02985	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
CWR58_RS02990	COG1053	succinate dehydrogenase
CWR58_RS03000	COG2030	dehydratase
CWR58_RS03010	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CWR58_RS03015	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CWR58_RS03020	COG3181	Tripartite tricarboxylate transporter family receptor
CWR58_RS03045	COG0559	Belongs to the binding-protein-dependent transport system permease family
CWR58_RS03065	COG0446	pyridine nucleotide-disulphide oxidoreductase
CWR58_RS03065	COG1902	pentaerythritol trinitrate reductase activity
CWR58_RS03080	COG0427	acetyl-CoA hydrolase
CWR58_RS03085	COG0318	PFAM AMP-dependent synthetase and ligase
CWR58_RS03100	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CWR58_RS03120	COG0183	Belongs to the thiolase family
CWR58_RS03125	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CWR58_RS03135	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CWR58_RS03140	COG0583	DNA-binding transcription factor activity
CWR58_RS03145	COG1960	acyl-CoA dehydrogenase activity
CWR58_RS03160	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
CWR58_RS03185	COG1309	transcriptional regulator
CWR58_RS03195	COG1024	Enoyl-CoA hydratase
CWR58_RS03215	COG1024	Enoyl-CoA hydratase
CWR58_RS03220	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CWR58_RS03225	COG3181	Tripartite tricarboxylate transporter family receptor
CWR58_RS03230	COG1454	alcohol dehydrogenase
CWR58_RS03235	COG1024	Enoyl-CoA hydratase
CWR58_RS03255	COG1012	belongs to the aldehyde dehydrogenase family
CWR58_RS03260	COG0431	NADPH-dependent FMN reductase
CWR58_RS03265	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CWR58_RS03270	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
CWR58_RS03285	COG1414	Transcriptional regulator
CWR58_RS03290	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CWR58_RS03295	COG1028	Short-chain dehydrogenase reductase Sdr
CWR58_RS03300	COG3181	Tripartite tricarboxylate transporter family receptor
CWR58_RS03325	COG0318	PFAM AMP-dependent synthetase and ligase
CWR58_RS03345	COG1024	Enoyl-CoA hydratase
CWR58_RS03355	COG1960	acyl-CoA dehydrogenase activity
CWR58_RS03360	COG1024	Enoyl-CoA hydratase
CWR58_RS03365	COG0183	Belongs to the thiolase family
CWR58_RS03370	COG3181	Tripartite tricarboxylate transporter family receptor
CWR58_RS03385	COG0583	DNA-binding transcription factor activity
CWR58_RS03390	COG2267	carboxylic ester hydrolase activity
CWR58_RS03405	COG0625	glutathione transferase activity
CWR58_RS03410	COG3181	Tripartite tricarboxylate transporter family receptor
CWR58_RS03420	COG2186	Transcriptional regulator
CWR58_RS03425	COG1012	belongs to the aldehyde dehydrogenase family
CWR58_RS03430	COG0626	cystathionine gamma-synthase activity
CWR58_RS03470	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CWR58_RS03475	COG0436	Aminotransferase
CWR58_RS03480	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CWR58_RS03485	COG0765	amino acid transport
CWR58_RS03495	COG1473	amidohydrolase
CWR58_RS03500	COG1414	Transcriptional regulator
CWR58_RS03510	COG0154	amidase activity
CWR58_RS03570	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CWR58_RS03585	COG3135	benzoate transporter
CWR58_RS03630	COG5444	nuclease activity
CWR58_RS03750	COG3468	outer membrane autotransporter barrel domain protein
CWR58_RS03815	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CWR58_RS03860	COG0489	protein tyrosine kinase activity
CWR58_RS03905	COG2081	HI0933 family
CWR58_RS03910	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CWR58_RS03925	COG0509	glycine decarboxylation via glycine cleavage system
CWR58_RS03950	COG1024	Enoyl-CoA hydratase
CWR58_RS03970	COG4172	Belongs to the ABC transporter superfamily
CWR58_RS03975	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CWR58_RS03980	COG0601	transmembrane transport
CWR58_RS03985	COG0747	negative chemotaxis
CWR58_RS03995	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CWR58_RS04025	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CWR58_RS04030	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CWR58_RS04045	COG0438	transferase activity, transferring glycosyl groups
CWR58_RS04060	COG0438	transferase activity, transferring glycosyl groups
CWR58_RS04065	COG0438	transferase activity, transferring glycosyl groups
CWR58_RS04070	COG0166	Belongs to the GPI family
CWR58_RS04085	COG0277	FAD linked oxidase domain protein
CWR58_RS04090	COG0745	RESPONSE REGULATOR receiver
CWR58_RS04095	COG0642	Histidine kinase
CWR58_RS04100	COG1368	sulfuric ester hydrolase activity
CWR58_RS04185	COG0012	GTP binding
CWR58_RS04200	COG0745	RESPONSE REGULATOR receiver
CWR58_RS04205	COG3181	Tripartite tricarboxylate transporter family receptor
CWR58_RS04210	COG1309	transcriptional regulator
CWR58_RS04220	COG2814	Major facilitator Superfamily
CWR58_RS04245	COG0281	malic enzyme
CWR58_RS04245	COG0280	phosphate acetyltransferase
CWR58_RS04255	COG0601	transmembrane transport
CWR58_RS04260	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CWR58_RS04265	COG4172	Belongs to the ABC transporter superfamily
CWR58_RS04280	COG0583	DNA-binding transcription factor activity
CWR58_RS04295	COG0640	Transcriptional regulator
CWR58_RS04310	COG3135	benzoate transporter
CWR58_RS04315	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CWR58_RS04320	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CWR58_RS04325	COG0742	ribosomal rna small subunit methyltransferase
CWR58_RS04340	COG3639	organic phosphonate transmembrane transporter activity
CWR58_RS04345	COG3639	organic phosphonate transmembrane transporter activity
CWR58_RS04375	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CWR58_RS04380	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CWR58_RS04390	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CWR58_RS04395	COG1058	Belongs to the CinA family
CWR58_RS04395	COG1546	Belongs to the CinA family
CWR58_RS04400	COG0284	orotidine-5'-phosphate decarboxylase activity
CWR58_RS04405	COG1252	NADH dehydrogenase
CWR58_RS04430	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CWR58_RS04450	COG1053	succinate dehydrogenase
CWR58_RS04460	COG0583	DNA-binding transcription factor activity
CWR58_RS04465	COG1053	succinate dehydrogenase
CWR58_RS04470	COG3181	Tripartite tricarboxylate transporter family receptor
CWR58_RS04475	COG1414	Transcriptional regulator
CWR58_RS04490	COG1335	isochorismatase
CWR58_RS04505	COG0405	Gamma-glutamyltransferase
CWR58_RS04520	COG1960	acyl-CoA dehydrogenase activity
CWR58_RS04525	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CWR58_RS04530	COG3181	Tripartite tricarboxylate transporter family receptor
CWR58_RS04535	COG0583	DNA-binding transcription factor activity
CWR58_RS04560	COG3181	Tripartite tricarboxylate transporter family receptor
CWR58_RS04565	COG0583	DNA-binding transcription factor activity
CWR58_RS04570	COG2199	diguanylate cyclase activity
CWR58_RS04625	COG1024	Enoyl-CoA hydratase
CWR58_RS04625	COG1250	3-hydroxyacyl-CoA dehydrogenase
CWR58_RS04630	COG0318	PFAM AMP-dependent synthetase and ligase
CWR58_RS04645	COG1024	Enoyl-CoA hydratase
CWR58_RS04650	COG1024	Enoyl-CoA hydratase
CWR58_RS04655	COG0318	PFAM AMP-dependent synthetase and ligase
CWR58_RS04660	COG1960	acyl-CoA dehydrogenase activity
CWR58_RS04700	COG3685	Protein conserved in bacteria
CWR58_RS04710	COG0387	Pfam Sodium calcium exchanger
CWR58_RS04715	COG3795	YCII-related domain
CWR58_RS04720	COG2188	Transcriptional regulator
CWR58_RS04740	COG0154	amidase activity
CWR58_RS04745	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CWR58_RS04750	COG1024	Enoyl-CoA hydratase
CWR58_RS04760	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CWR58_RS04775	COG1028	Short-chain dehydrogenase reductase Sdr
CWR58_RS04780	COG1414	Transcriptional regulator
CWR58_RS04795	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CWR58_RS04800	COG0251	oxidation-reduction process
CWR58_RS04805	COG0559	Belongs to the binding-protein-dependent transport system permease family
CWR58_RS04825	COG1902	pentaerythritol trinitrate reductase activity
CWR58_RS04830	COG0583	DNA-binding transcription factor activity
CWR58_RS04840	COG0590	tRNA wobble adenosine to inosine editing
CWR58_RS04845	COG2807	transmembrane transport
CWR58_RS04850	COG0307	riboflavin synthase, alpha
CWR58_RS04855	COG3181	Tripartite tricarboxylate transporter family receptor
CWR58_RS04860	COG1522	sequence-specific DNA binding
CWR58_RS04870	COG0318	PFAM AMP-dependent synthetase and ligase
CWR58_RS04880	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CWR58_RS04920	COG1418	mRNA catabolic process
CWR58_RS04930	COG1335	isochorismatase
CWR58_RS04955	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CWR58_RS04960	COG2274	protein secretion by the type I secretion system
CWR58_RS04970	COG1538	Outer membrane efflux protein
CWR58_RS04975	COG0493	'glutamate synthase
CWR58_RS04975	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CWR58_RS04985	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CWR58_RS04995	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CWR58_RS05005	COG1309	transcriptional regulator
CWR58_RS05010	COG1960	acyl-CoA dehydrogenase activity
CWR58_RS05015	COG1028	Short-chain dehydrogenase reductase Sdr
CWR58_RS05020	COG2076	Multidrug Resistance protein
CWR58_RS05025	COG1309	transcriptional regulator
CWR58_RS05045	COG0840	transmembrane signaling receptor activity
CWR58_RS05060	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CWR58_RS05085	COG1012	belongs to the aldehyde dehydrogenase family
CWR58_RS05095	COG1024	Enoyl-CoA hydratase
CWR58_RS05105	COG2203	Gaf domain
CWR58_RS05105	COG2199	diguanylate cyclase activity
CWR58_RS05125	COG0154	amidase activity
CWR58_RS05130	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CWR58_RS05130	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CWR58_RS05155	COG3945	hemerythrin HHE cation binding domain
CWR58_RS05170	COG2169	Transcriptional regulator
CWR58_RS05170	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CWR58_RS05190	COG1271	oxidase subunit
CWR58_RS05195	COG1294	oxidase, subunit
CWR58_RS05205	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CWR58_RS05235	COG0596	Alpha beta hydrolase
CWR58_RS05240	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CWR58_RS05275	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CWR58_RS05280	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CWR58_RS05290	COG2070	2-Nitropropane dioxygenase
CWR58_RS05305	COG2207	Transcriptional regulator
CWR58_RS05305	COG1917	Cupin 2, conserved barrel domain protein
CWR58_RS05325	COG2900	Belongs to the SlyX family
CWR58_RS05335	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CWR58_RS05365	COG0583	DNA-binding transcription factor activity
CWR58_RS05370	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CWR58_RS05380	COG0583	DNA-binding transcription factor activity
CWR58_RS05405	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
CWR58_RS05415	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CWR58_RS05420	COG1845	cytochrome c oxidase, subunit III
CWR58_RS05425	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
CWR58_RS05430	COG0640	Transcriptional regulator
CWR58_RS05495	COG1666	GTP binding
CWR58_RS05520	COG1028	Short-chain dehydrogenase reductase Sdr
CWR58_RS05530	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
CWR58_RS05535	COG1845	cytochrome c oxidase, subunit III
CWR58_RS05540	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CWR58_RS05545	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CWR58_RS05550	COG0477	Major facilitator Superfamily
CWR58_RS05565	COG5006	permease, DMT superfamily
CWR58_RS05585	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CWR58_RS05600	COG3383	formate dehydrogenase (NAD+) activity
CWR58_RS05620	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CWR58_RS05625	COG0303	'Molybdopterin
CWR58_RS05630	COG0521	Mo-molybdopterin cofactor biosynthetic process
CWR58_RS05640	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
CWR58_RS05655	COG0412	Dienelactone hydrolase
CWR58_RS05665	COG0678	peroxiredoxin activity
CWR58_RS05675	COG0697	spore germination
CWR58_RS05720	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CWR58_RS05725	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CWR58_RS05730	COG1335	isochorismatase
CWR58_RS05735	COG0523	cobalamin synthesis protein
CWR58_RS05740	COG3181	Tripartite tricarboxylate transporter family receptor
CWR58_RS05755	COG3181	Tripartite tricarboxylate transporter family receptor
CWR58_RS05765	COG1802	Transcriptional regulator
CWR58_RS05785	COG0667	Aldo Keto reductase
CWR58_RS05795	COG4535	Mg2 and Co2 transporter CorC
CWR58_RS05805	COG1702	phosphate starvation-inducible protein PhoH
CWR58_RS05820	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CWR58_RS05825	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CWR58_RS05830	COG1862	Preprotein translocase
CWR58_RS05835	COG0343	queuine tRNA-ribosyltransferase activity
CWR58_RS05845	COG2027	D-alanyl-D-alanine carboxypeptidase
CWR58_RS05890	COG0741	lytic transglycosylase activity
CWR58_RS05900	COG0436	Aminotransferase
CWR58_RS05910	COG0280	phosphate acetyltransferase
CWR58_RS05910	COG0281	malic enzyme
CWR58_RS05920	COG2732	(Barnase) inhibitor
CWR58_RS05925	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CWR58_RS05930	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CWR58_RS05935	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CWR58_RS05945	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CWR58_RS05950	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CWR58_RS05965	COG0625	glutathione transferase activity
CWR58_RS05995	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CWR58_RS06005	COG0306	phosphate transporter
CWR58_RS06010	COG0521	Mo-molybdopterin cofactor biosynthetic process
CWR58_RS06020	COG0739	heme binding
CWR58_RS06030	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CWR58_RS06080	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CWR58_RS06105	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CWR58_RS06110	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CWR58_RS06115	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CWR58_RS06120	COG0009	L-threonylcarbamoyladenylate synthase
CWR58_RS06125	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CWR58_RS06130	COG1414	Transcriptional regulator
CWR58_RS06145	COG0765	amino acid transport
CWR58_RS06150	COG1126	abc transporter atp-binding protein
CWR58_RS06170	COG0028	Belongs to the TPP enzyme family
CWR58_RS06175	COG0583	DNA-binding transcription factor activity
CWR58_RS06180	COG4974	Belongs to the 'phage' integrase family
CWR58_RS06185	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CWR58_RS06190	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
CWR58_RS06200	COG1686	Belongs to the peptidase S11 family
CWR58_RS06210	COG2814	Major facilitator Superfamily
CWR58_RS06220	COG1074	ATP-dependent DNA helicase activity
CWR58_RS06230	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CWR58_RS06245	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CWR58_RS06250	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CWR58_RS06260	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CWR58_RS06270	COG0505	Belongs to the CarA family
CWR58_RS06275	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CWR58_RS06310	COG0613	PHP domain protein
CWR58_RS06325	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CWR58_RS06325	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CWR58_RS06330	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CWR58_RS06335	COG0047	phosphoribosylformylglycinamidine synthase activity
CWR58_RS06335	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CWR58_RS06340	COG3210	domain, Protein
CWR58_RS06340	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
CWR58_RS06340	COG3064	Membrane
CWR58_RS06360	COG3181	Tripartite tricarboxylate transporter family receptor
CWR58_RS06380	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CWR58_RS06400	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CWR58_RS06405	COG2197	response regulator
CWR58_RS06445	COG1061	Type III restriction enzyme res subunit
CWR58_RS06450	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CWR58_RS06470	COG0477	Major facilitator Superfamily
CWR58_RS06475	COG2814	Major facilitator Superfamily
CWR58_RS06490	COG0625	glutathione transferase activity
CWR58_RS06505	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CWR58_RS06520	COG3618	amidohydrolase
CWR58_RS06535	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CWR58_RS06555	COG2079	MmgE PrpD family protein
CWR58_RS06560	COG1012	belongs to the aldehyde dehydrogenase family
CWR58_RS06595	COG1280	lysine exporter protein (LysE YggA)
CWR58_RS06610	COG0747	negative chemotaxis
CWR58_RS06615	COG0601	transmembrane transport
CWR58_RS06625	COG4172	Belongs to the ABC transporter superfamily
CWR58_RS06630	COG1609	Transcriptional regulator
CWR58_RS06645	COG0789	Transcriptional regulator
CWR58_RS06670	COG2188	Transcriptional regulator
CWR58_RS06675	COG3181	Tripartite tricarboxylate transporter family receptor
CWR58_RS06695	COG1802	Transcriptional regulator
CWR58_RS06715	COG0842	Transport permease protein
CWR58_RS06740	COG0656	L-ascorbic acid biosynthetic process
CWR58_RS06745	COG3284	Transcriptional regulator
CWR58_RS06750	COG1012	belongs to the aldehyde dehydrogenase family
CWR58_RS06765	COG2733	membrane
CWR58_RS06770	COG0583	DNA-binding transcription factor activity
CWR58_RS06775	COG0384	phenazine biosynthesis protein PhzF
CWR58_RS06780	COG5507	3-demethylubiquinone-9 3-methyltransferase
CWR58_RS06815	COG0659	secondary active sulfate transmembrane transporter activity
CWR58_RS06840	COG1132	(ABC) transporter
CWR58_RS06880	COG2207	Transcriptional regulator
CWR58_RS06915	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CWR58_RS06920	COG1280	lysine exporter protein (LysE YggA)
CWR58_RS06940	COG0625	glutathione transferase activity
CWR58_RS06955	COG0697	spore germination
CWR58_RS06990	COG3246	L-lysine catabolic process to acetate
CWR58_RS06995	COG1250	3-hydroxyacyl-CoA dehydrogenase
CWR58_RS07000	COG0583	DNA-binding transcription factor activity
CWR58_RS07015	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CWR58_RS07020	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CWR58_RS07025	COG3622	Belongs to the hyi family
CWR58_RS07035	COG0129	dihydroxy-acid dehydratase activity
CWR58_RS07050	COG0129	dihydroxy-acid dehydratase activity
CWR58_RS07055	COG3181	Tripartite tricarboxylate transporter family receptor
CWR58_RS07065	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CWR58_RS07080	COG2188	Transcriptional regulator
CWR58_RS07090	COG0583	DNA-binding transcription factor activity
CWR58_RS07100	COG0501	Belongs to the peptidase M48B family
CWR58_RS07110	COG2814	Major facilitator Superfamily
CWR58_RS07115	COG0583	DNA-binding transcription factor activity
CWR58_RS07150	COG4691	Plasmid stability protein
CWR58_RS07180	COG2837	iron assimilation
CWR58_RS07200	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CWR58_RS07205	COG1335	isochorismatase
CWR58_RS07265	COG2346	COG2346, Truncated hemoglobins
CWR58_RS07275	COG1126	abc transporter atp-binding protein
CWR58_RS07280	COG0765	amino acid transport
CWR58_RS07285	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CWR58_RS07295	COG0789	Transcriptional regulator
CWR58_RS07305	COG0165	Argininosuccinate lyase
CWR58_RS07310	COG0668	transmembrane transport
CWR58_RS07360	COG0747	negative chemotaxis
CWR58_RS07365	COG0601	transmembrane transport
CWR58_RS07370	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CWR58_RS07380	COG1280	lysine exporter protein (LysE YggA)
CWR58_RS07400	COG3161	chorismate lyase activity
CWR58_RS07405	COG1187	pseudouridine synthase activity
CWR58_RS07415	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CWR58_RS07435	COG1999	signal sequence binding
CWR58_RS07440	COG0339	signal peptide processing
CWR58_RS07445	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CWR58_RS07450	COG4566	intracellular signal transduction
CWR58_RS07460	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CWR58_RS07465	COG0508	dehydrogenase complex catalyzes the overall conversion of
CWR58_RS07470	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CWR58_RS07475	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CWR58_RS07505	COG0745	RESPONSE REGULATOR receiver
CWR58_RS07510	COG0643	Histidine kinase
CWR58_RS07510	COG2198	Histidine kinase
CWR58_RS07520	COG0840	transmembrane signaling receptor activity
CWR58_RS07525	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CWR58_RS07535	COG0745	RESPONSE REGULATOR receiver
CWR58_RS07540	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
CWR58_RS07575	COG1815	bacterial-type flagellum-dependent cell motility
CWR58_RS07580	COG1558	bacterial-type flagellum-dependent cell motility
CWR58_RS07590	COG1749	Flagellar hook protein flgE
CWR58_RS07620	COG1256	bacterial-type flagellum assembly
CWR58_RS07630	COG0840	transmembrane signaling receptor activity
CWR58_RS07650	COG1338	Plays a role in the flagellum-specific transport system
CWR58_RS07670	COG1580	Controls the rotational direction of flagella during chemotaxis
CWR58_RS07685	COG1157	protein secretion by the type III secretion system
CWR58_RS07690	COG1317	bacterial-type flagellum organization
CWR58_RS07695	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CWR58_RS07705	COG1677	Flagellar hook-basal body complex protein FliE
CWR58_RS07715	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CWR58_RS07745	COG0285	dihydrofolate synthase activity
CWR58_RS07780	COG0024	Methionine aminopeptidase
CWR58_RS07785	COG0052	Belongs to the universal ribosomal protein uS2 family
CWR58_RS07800	COG0233	cytoplasmic translational termination
CWR58_RS07805	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CWR58_RS07820	COG0750	zinc metalloprotease
CWR58_RS07825	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CWR58_RS07830	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
CWR58_RS07855	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CWR58_RS07860	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CWR58_RS07885	COG0330	HflC and HflK could
CWR58_RS07900	COG2867	negative regulation of translational initiation
CWR58_RS07910	COG1960	acyl-CoA dehydrogenase activity
CWR58_RS07915	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CWR58_RS07940	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CWR58_RS07945	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CWR58_RS07950	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CWR58_RS07955	COG0084	hydrolase, TatD family'
CWR58_RS07980	COG1126	abc transporter atp-binding protein
CWR58_RS07990	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CWR58_RS07995	COG1012	belongs to the aldehyde dehydrogenase family
CWR58_RS08005	COG0028	Belongs to the TPP enzyme family
CWR58_RS08035	COG3189	MarR family transcriptional regulator
CWR58_RS08065	COG1595	DNA-templated transcription, initiation
CWR58_RS08075	COG0861	Integral membrane protein TerC family
CWR58_RS08100	COG2988	succinylglutamate desuccinylase activity
CWR58_RS08115	COG1253	flavin adenine dinucleotide binding
CWR58_RS08125	COG3181	Tripartite tricarboxylate transporter family receptor
CWR58_RS08130	COG2084	Dehydrogenase
CWR58_RS08165	COG2814	Major facilitator Superfamily
CWR58_RS08175	COG0583	DNA-binding transcription factor activity
CWR58_RS08205	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CWR58_RS08210	COG4943	cyclic-guanylate-specific phosphodiesterase activity
CWR58_RS08215	COG0840	transmembrane signaling receptor activity
CWR58_RS08240	COG3468	outer membrane autotransporter barrel domain protein
CWR58_RS08245	COG3468	outer membrane autotransporter barrel domain protein
CWR58_RS08280	COG5265	(ABC) transporter
CWR58_RS08290	COG0667	Aldo Keto reductase
CWR58_RS08305	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CWR58_RS08345	COG1959	2 iron, 2 sulfur cluster binding
CWR58_RS08370	COG0400	carboxylic ester hydrolase activity
CWR58_RS08380	COG1566	PFAM secretion protein HlyD family protein
CWR58_RS08405	COG0235	Class ii aldolase
CWR58_RS08410	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CWR58_RS08415	COG0720	synthase
CWR58_RS08420	COG0602	queuosine metabolic process
CWR58_RS08440	COG4208	sulfate ABC transporter
CWR58_RS08450	COG0175	sulfate reduction
CWR58_RS08480	COG0335	large ribosomal subunit rRNA binding
CWR58_RS08490	COG0667	Aldo Keto reductase
CWR58_RS08495	COG1162	GTPase activity
CWR58_RS08500	COG0501	Belongs to the peptidase M48B family
CWR58_RS08505	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
CWR58_RS08520	COG3396	Phenylacetate-CoA oxygenase
CWR58_RS08525	COG3460	Phenylacetate-CoA oxygenase
CWR58_RS08530	COG3396	Phenylacetate-CoA oxygenase
CWR58_RS08535	COG2151	metal-sulfur cluster biosynthetic enzyme
CWR58_RS08540	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CWR58_RS08545	COG1012	belongs to the aldehyde dehydrogenase family
CWR58_RS08550	COG1024	Enoyl-CoA hydratase
CWR58_RS08555	COG2050	protein possibly involved in aromatic compounds catabolism
CWR58_RS08570	COG3539	Fimbrial protein
CWR58_RS08575	COG3539	Fimbrial protein
CWR58_RS08580	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CWR58_RS08580	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CWR58_RS08590	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CWR58_RS08595	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
CWR58_RS08610	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CWR58_RS08615	COG3842	ATPase activity
CWR58_RS08620	COG1176	ABC-type spermidine putrescine transport system, permease component I
CWR58_RS08625	COG1177	transmembrane transport
CWR58_RS08650	COG1960	acyl-CoA dehydrogenase activity
CWR58_RS08660	COG0704	Plays a role in the regulation of phosphate uptake
CWR58_RS08670	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
CWR58_RS08675	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CWR58_RS08675	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CWR58_RS08680	COG1643	Atp-dependent helicase
CWR58_RS08695	COG0438	transferase activity, transferring glycosyl groups
CWR58_RS08700	COG0726	polysaccharide deacetylase
CWR58_RS08705	COG0463	Glycosyl transferase, family 2
CWR58_RS08710	COG0438	transferase activity, transferring glycosyl groups
CWR58_RS08715	COG2194	sulfuric ester hydrolase activity
CWR58_RS08740	COG0859	PFAM glycosyl transferase family 9
CWR58_RS08745	COG1132	(ABC) transporter
CWR58_RS08760	COG0077	Prephenate dehydratase
CWR58_RS08765	COG1530	ribonuclease E activity
CWR58_RS08805	COG1250	3-hydroxyacyl-CoA dehydrogenase
CWR58_RS08810	COG0154	amidase activity
CWR58_RS08840	COG2814	Major facilitator Superfamily
CWR58_RS08860	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CWR58_RS08865	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CWR58_RS08870	COG2814	Major facilitator Superfamily
CWR58_RS08875	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CWR58_RS08885	COG4176	ABC-type proline glycine betaine transport system permease component
CWR58_RS08895	COG1942	4-Oxalocrotonate Tautomerase
CWR58_RS08900	COG0183	Belongs to the thiolase family
CWR58_RS08910	COG1802	Transcriptional regulator
CWR58_RS08920	COG1024	Enoyl-CoA hydratase
CWR58_RS08925	COG0318	PFAM AMP-dependent synthetase and ligase
CWR58_RS08935	COG2032	superoxide dismutase activity
CWR58_RS08950	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
CWR58_RS08975	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CWR58_RS08990	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CWR58_RS08995	COG0736	holo-[acyl-carrier-protein] synthase activity
CWR58_RS09010	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CWR58_RS09025	COG2224	Isocitrate lyase
CWR58_RS09035	COG1346	cytolysis
CWR58_RS09040	COG1380	Effector of murein hydrolase LrgA
CWR58_RS09045	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CWR58_RS09045	COG4106	trans-aconitate 2-methyltransferase activity
CWR58_RS09075	COG3278	Belongs to the heme-copper respiratory oxidase family
CWR58_RS09120	COG1131	(ABC) transporter
CWR58_RS09125	COG0842	Transport permease protein
CWR58_RS09130	COG0628	permease
CWR58_RS09145	COG2814	Major facilitator Superfamily
CWR58_RS09150	COG2841	Protein conserved in bacteria
CWR58_RS09175	COG0765	amino acid transport
CWR58_RS09180	COG0765	amino acid transport
CWR58_RS09185	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CWR58_RS09220	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CWR58_RS09225	COG1595	DNA-templated transcription, initiation
CWR58_RS09235	COG3530	Putative quorum-sensing-regulated virulence factor
CWR58_RS09240	COG0494	nUDIX hydrolase
CWR58_RS09255	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CWR58_RS09265	COG3468	outer membrane autotransporter barrel domain protein
CWR58_RS09280	COG5564	TIM-barrel signal transduction protein
CWR58_RS09295	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
CWR58_RS09330	COG1131	(ABC) transporter
CWR58_RS09350	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
CWR58_RS09350	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
CWR58_RS09355	COG1562	ergosterol biosynthetic process
CWR58_RS09360	COG1562	ergosterol biosynthetic process
CWR58_RS09365	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CWR58_RS09385	COG2304	oxidoreductase activity
CWR58_RS09445	COG1047	Peptidyl-prolyl cis-trans
CWR58_RS09450	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CWR58_RS09455	COG0625	glutathione transferase activity
CWR58_RS09475	COG0523	cobalamin synthesis protein
CWR58_RS09485	COG0583	DNA-binding transcription factor activity
CWR58_RS09495	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CWR58_RS09500	COG1187	pseudouridine synthase activity
CWR58_RS09510	COG0195	Participates in both transcription termination and antitermination
CWR58_RS09510	COG2251	uridine kinase activity
CWR58_RS09545	COG1611	Belongs to the LOG family
CWR58_RS09560	COG0412	Dienelactone hydrolase
CWR58_RS09565	COG1283	sodium-dependent phosphate transmembrane transporter activity
CWR58_RS09570	COG1760	l-serine dehydratase
CWR58_RS09575	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CWR58_RS09590	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CWR58_RS09615	COG2311	Membrane
CWR58_RS09625	COG2358	TRAP transporter, solute receptor (TAXI family
CWR58_RS09630	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CWR58_RS09670	COG3395	kinase activity
CWR58_RS09675	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CWR58_RS09710	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CWR58_RS09750	COG4964	Belongs to the GSP D family
CWR58_RS09785	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CWR58_RS09795	COG1295	ribonuclease BN
CWR58_RS09810	COG0745	RESPONSE REGULATOR receiver
CWR58_RS09815	COG2205	protein histidine kinase activity
CWR58_RS09820	COG5001	Diguanylate cyclase
CWR58_RS09835	COG1763	Mo-molybdopterin cofactor biosynthetic process
CWR58_RS09840	COG0303	'Molybdopterin
CWR58_RS09845	COG0746	molybdenum cofactor guanylyltransferase activity
CWR58_RS09850	COG0489	protein tyrosine kinase activity
CWR58_RS09880	COG3383	formate dehydrogenase (NAD+) activity
CWR58_RS09880	COG0243	molybdopterin cofactor binding
CWR58_RS09885	COG0437	4 iron, 4 sulfur cluster binding
CWR58_RS09915	COG1122	ATPase activity
CWR58_RS09940	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CWR58_RS09955	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CWR58_RS10015	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CWR58_RS10025	COG2197	response regulator
CWR58_RS10030	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CWR58_RS10035	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CWR58_RS10050	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CWR58_RS10055	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CWR58_RS10065	COG1764	response to oxidative stress
CWR58_RS10070	COG2423	ornithine cyclodeaminase activity
CWR58_RS10080	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CWR58_RS10085	COG0765	amino acid transport
CWR58_RS10090	COG0765	amino acid transport
CWR58_RS10095	COG1126	abc transporter atp-binding protein
CWR58_RS10120	COG1522	sequence-specific DNA binding
CWR58_RS10130	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CWR58_RS10135	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CWR58_RS10145	COG0196	riboflavin kinase activity
CWR58_RS10150	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CWR58_RS10155	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CWR58_RS10155	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CWR58_RS10170	COG0210	DNA helicase
CWR58_RS10175	COG4771	TonB-dependent receptor
CWR58_RS10180	COG0488	(ABC) transporter
CWR58_RS10185	COG2890	protein-(glutamine-N5) methyltransferase activity
CWR58_RS10200	COG0436	Aminotransferase
CWR58_RS10230	COG1278	Cold shock
CWR58_RS10240	COG1278	Cold shock
CWR58_RS10255	COG0740	serine-type endopeptidase activity
CWR58_RS10265	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CWR58_RS10270	COG0583	DNA-binding transcription factor activity
CWR58_RS10275	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CWR58_RS10290	COG1024	Enoyl-CoA hydratase
CWR58_RS10305	COG1028	Short-chain dehydrogenase reductase Sdr
CWR58_RS10310	COG1960	acyl-CoA dehydrogenase activity
CWR58_RS10325	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CWR58_RS10335	COG3468	outer membrane autotransporter barrel domain protein
CWR58_RS10355	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CWR58_RS10365	COG1104	cysteine desulfurase activity
CWR58_RS10370	COG0822	iron-sulfur transferase activity
CWR58_RS10375	COG0316	Belongs to the HesB IscA family
CWR58_RS10390	COG0633	Ferredoxin
CWR58_RS10405	COG1024	Enoyl-CoA hydratase
CWR58_RS10435	COG1022	Amp-dependent synthetase and ligase
CWR58_RS10455	COG1028	Short-chain dehydrogenase reductase Sdr
CWR58_RS10465	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CWR58_RS10480	COG1136	(ABC) transporter
CWR58_RS10485	COG0084	hydrolase, TatD family'
CWR58_RS10500	COG4221	oxidoreductase activity
CWR58_RS10505	COG0406	alpha-ribazole phosphatase activity
CWR58_RS10515	COG3842	ATPase activity
CWR58_RS10530	COG2233	PERMEase
CWR58_RS10535	COG0840	transmembrane signaling receptor activity
CWR58_RS10540	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CWR58_RS10550	COG1534	Rna-binding protein
CWR58_RS10560	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CWR58_RS10580	COG0248	Ppx GppA phosphatase
CWR58_RS10680	COG0559	Belongs to the binding-protein-dependent transport system permease family
CWR58_RS10710	COG0559	Belongs to the binding-protein-dependent transport system permease family
CWR58_RS10745	COG2072	flavoprotein involved in K transport
CWR58_RS10750	COG1250	3-hydroxyacyl-CoA dehydrogenase
CWR58_RS10780	COG1137	ATPase activity
CWR58_RS10790	COG0154	amidase activity
CWR58_RS10795	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CWR58_RS10815	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CWR58_RS10820	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CWR58_RS10825	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CWR58_RS10835	COG0179	Fumarylacetoacetate (FAA) hydrolase
CWR58_RS10845	COG1522	sequence-specific DNA binding
CWR58_RS10850	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CWR58_RS10855	COG1473	amidohydrolase
CWR58_RS10860	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CWR58_RS10865	COG4597	amino acid ABC transporter
CWR58_RS10870	COG0765	amino acid transport
CWR58_RS10875	COG1126	abc transporter atp-binding protein
CWR58_RS10890	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CWR58_RS10920	COG3181	Tripartite tricarboxylate transporter family receptor
CWR58_RS10940	COG0583	DNA-binding transcription factor activity
CWR58_RS10975	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CWR58_RS11015	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CWR58_RS11025	COG1132	(ABC) transporter
CWR58_RS11050	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
CWR58_RS11060	COG1012	belongs to the aldehyde dehydrogenase family
CWR58_RS11070	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CWR58_RS11080	COG0511	ligase activity, forming carbon-carbon bonds
CWR58_RS11105	COG2188	Transcriptional regulator
CWR58_RS11110	COG0439	Biotin carboxylase
CWR58_RS11120	COG0511	ligase activity, forming carbon-carbon bonds
CWR58_RS11135	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CWR58_RS11165	COG3971	2-oxopent-4-enoate hydratase activity
CWR58_RS11170	COG0583	DNA-binding transcription factor activity
CWR58_RS11185	COG0179	Fumarylacetoacetate (FAA) hydrolase
CWR58_RS11235	COG1028	Short-chain dehydrogenase reductase Sdr
CWR58_RS11275	COG0251	oxidation-reduction process
CWR58_RS11375	COG4669	(LipO)protein
CWR58_RS11410	COG4790	Type iii secretion
CWR58_RS11415	COG4794	Type iii secretion
CWR58_RS11420	COG4791	protein targeting
CWR58_RS11425	COG4792	protein secretion
CWR58_RS11465	COG2770	Histidine kinase
CWR58_RS11465	COG2208	phosphoserine phosphatase activity
CWR58_RS11475	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CWR58_RS11485	COG1366	Belongs to the anti-sigma-factor antagonist family
CWR58_RS11490	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CWR58_RS11530	COG2321	neutral zinc metallopeptidase
CWR58_RS11535	COG0009	L-threonylcarbamoyladenylate synthase
CWR58_RS11540	COG1994	Peptidase M50
CWR58_RS11545	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CWR58_RS11550	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
CWR58_RS11555	COG3539	Fimbrial protein
CWR58_RS11565	COG2850	peptidyl-arginine hydroxylation
CWR58_RS11575	COG3360	Dodecin
CWR58_RS11610	COG0668	transmembrane transport
CWR58_RS11630	COG0483	inositol monophosphate 1-phosphatase activity
CWR58_RS11635	COG1253	flavin adenine dinucleotide binding
CWR58_RS11655	COG3063	Type IV pilus biogenesis stability protein PilW
CWR58_RS11670	COG0825	malonyl-CoA metabolic process
CWR58_RS11680	COG0527	aspartate kinase activity
CWR58_RS11705	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CWR58_RS11705	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CWR58_RS11720	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CWR58_RS11730	COG1028	Short-chain dehydrogenase reductase Sdr
CWR58_RS11740	COG0583	DNA-binding transcription factor activity
CWR58_RS11765	COG3842	ATPase activity
CWR58_RS11775	COG1902	pentaerythritol trinitrate reductase activity
CWR58_RS11775	COG0446	pyridine nucleotide-disulphide oxidoreductase
CWR58_RS11780	COG1414	Transcriptional regulator
CWR58_RS11785	COG1832	CoA-binding protein
CWR58_RS11795	COG0251	oxidation-reduction process
CWR58_RS11820	COG1902	pentaerythritol trinitrate reductase activity
CWR58_RS11830	COG1215	transferase activity, transferring glycosyl groups
CWR58_RS11835	COG1649	PFAM Uncharacterised BCR, COG1649
CWR58_RS11835	COG0726	polysaccharide deacetylase
CWR58_RS11855	COG1846	Transcriptional regulator
CWR58_RS11885	COG2080	2 iron, 2 sulfur cluster binding
CWR58_RS11890	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CWR58_RS11900	COG0596	Alpha beta hydrolase
CWR58_RS11905	COG2309	aminopeptidase activity
CWR58_RS11910	COG1335	isochorismatase
CWR58_RS11915	COG2010	Cytochrome c
CWR58_RS11915	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CWR58_RS11920	COG1017	nitric oxide dioxygenase activity
CWR58_RS11920	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CWR58_RS11935	COG3181	Tripartite tricarboxylate transporter family receptor
CWR58_RS11945	COG0318	PFAM AMP-dependent synthetase and ligase
CWR58_RS11955	COG0183	Belongs to the thiolase family
CWR58_RS11960	COG1024	Enoyl-CoA hydratase
CWR58_RS11960	COG1250	3-hydroxyacyl-CoA dehydrogenase
CWR58_RS11975	COG0183	Belongs to the thiolase family
CWR58_RS11990	COG2197	response regulator
CWR58_RS12005	COG0166	Belongs to the GPI family
CWR58_RS12010	COG1045	serine acetyltransferase
CWR58_RS12035	COG0483	inositol monophosphate 1-phosphatase activity
CWR58_RS12045	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CWR58_RS12065	COG0598	Magnesium transport protein CorA
CWR58_RS12075	COG0747	negative chemotaxis
CWR58_RS12080	COG0601	transmembrane transport
CWR58_RS12085	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CWR58_RS12090	COG4172	Belongs to the ABC transporter superfamily
CWR58_RS12140	COG4964	Belongs to the GSP D family
CWR58_RS12205	COG3474	cytochrome
CWR58_RS12210	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CWR58_RS12225	COG3384	dioxygenase
CWR58_RS12230	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CWR58_RS12250	COG2885	chlorophyll binding
CWR58_RS12285	COG0697	spore germination
CWR58_RS12290	COG0730	response to heat
CWR58_RS12305	COG3264	Mechanosensitive ion channel
CWR58_RS12305	COG1511	domain protein
CWR58_RS12310	COG0583	DNA-binding transcription factor activity
CWR58_RS12315	COG0427	acetyl-CoA hydrolase
CWR58_RS12320	COG0385	Bile acid
CWR58_RS12360	COG3468	outer membrane autotransporter barrel domain protein
CWR58_RS12375	COG0799	negative regulation of ribosome biogenesis
CWR58_RS12390	COG0151	Belongs to the GarS family
CWR58_RS12400	COG0433	COG0433 Predicted ATPase
CWR58_RS12405	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CWR58_RS12415	COG1012	belongs to the aldehyde dehydrogenase family
CWR58_RS12440	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CWR58_RS12450	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CWR58_RS12460	COG0747	negative chemotaxis
CWR58_RS12470	COG0473	3-isopropylmalate dehydrogenase activity
CWR58_RS12490	COG1846	Transcriptional regulator
CWR58_RS12500	COG0697	spore germination
CWR58_RS12510	COG0501	Belongs to the peptidase M48B family
CWR58_RS12530	COG0583	DNA-binding transcription factor activity
CWR58_RS12535	COG3842	ATPase activity
CWR58_RS12540	COG1178	ABC-type Fe3 transport system permease component
CWR58_RS12545	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CWR58_RS12550	COG1840	ABC-type Fe3 transport system, periplasmic component
CWR58_RS12585	COG3181	Tripartite tricarboxylate transporter family receptor
CWR58_RS12595	COG1722	exodeoxyribonuclease VII activity
CWR58_RS12600	COG0142	geranyltranstransferase activity
CWR58_RS12610	COG1469	GTP cyclohydrolase I activity
CWR58_RS12615	COG0360	Binds together with S18 to 16S ribosomal RNA
CWR58_RS12620	COG2965	DNA replication, synthesis of RNA primer
CWR58_RS12625	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CWR58_RS12645	COG0305	Participates in initiation and elongation during chromosome replication
CWR58_RS12655	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CWR58_RS12660	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CWR58_RS12665	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CWR58_RS12670	COG3737	Protein of unknown function (DUF498/DUF598)
CWR58_RS12675	COG0436	Aminotransferase
CWR58_RS12695	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
CWR58_RS12700	COG0308	aminopeptidase N
CWR58_RS12720	COG0312	modulator of DNA gyrase
CWR58_RS12725	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CWR58_RS12730	COG3064	Membrane
CWR58_RS12730	COG3064	Membrane
CWR58_RS12730	COG3210	domain, Protein
CWR58_RS12730	COG3210	domain, Protein
CWR58_RS12730	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
CWR58_RS12730	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
CWR58_RS12735	COG0277	FAD linked oxidase domain protein
CWR58_RS12740	COG0277	FAD linked oxidase domain protein
CWR58_RS12750	COG0247	lactate metabolic process
CWR58_RS12755	COG2819	hydrolase of the alpha beta superfamily
CWR58_RS12795	COG0583	DNA-binding transcription factor activity
CWR58_RS12805	COG0730	response to heat
CWR58_RS12810	COG0625	glutathione transferase activity
CWR58_RS12815	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CWR58_RS12820	COG3909	cytochrome
CWR58_RS12855	COG3706	GGDEF domain
CWR58_RS12895	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
CWR58_RS12905	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CWR58_RS12910	COG0069	glutamate synthase activity
CWR58_RS12915	COG2391	methyltransferase activity
CWR58_RS12920	COG0679	Auxin Efflux Carrier
CWR58_RS12945	COG0557	exoribonuclease II activity
CWR58_RS12950	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CWR58_RS12960	COG3128	pkhd-type hydroxylase
CWR58_RS12965	COG0776	regulation of translation
CWR58_RS12995	COG0642	Histidine kinase
CWR58_RS13000	COG3158	transport of potassium into the cell
CWR58_RS13010	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CWR58_RS13025	COG0583	DNA-binding transcription factor activity
CWR58_RS13035	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CWR58_RS13055	COG2186	Transcriptional regulator
CWR58_RS13060	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
CWR58_RS13080	COG0268	Binds directly to 16S ribosomal RNA
CWR58_RS13090	COG0728	peptidoglycan biosynthetic process
CWR58_RS13110	COG2835	tetraacyldisaccharide 4'-kinase activity
CWR58_RS13120	COG0848	biopolymer transport protein
CWR58_RS13125	COG0811	peptide transport
CWR58_RS13135	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CWR58_RS13140	COG0038	chloride channel
CWR58_RS13145	COG0183	Belongs to the thiolase family
CWR58_RS13155	COG1278	Cold shock
CWR58_RS13170	COG4953	penicillin-binding protein 1C
CWR58_RS13175	COG0542	response to heat
CWR58_RS13180	COG2995	paraquat-inducible protein a
CWR58_RS13185	COG3008	intermembrane lipid transfer
CWR58_RS13185	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CWR58_RS13195	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CWR58_RS13195	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CWR58_RS13195	COG0506	proline dehydrogenase activity
CWR58_RS13230	COG1309	transcriptional regulator
CWR58_RS13245	COG0004	ammonium transporteR
CWR58_RS13270	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CWR58_RS13275	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CWR58_RS13315	COG0500	methyltransferase
CWR58_RS13330	COG2367	Beta-lactamase
CWR58_RS13340	COG1522	sequence-specific DNA binding
CWR58_RS13355	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CWR58_RS13390	COG0540	Belongs to the ATCase OTCase family
CWR58_RS13405	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CWR58_RS13410	COG0583	DNA-binding transcription factor activity
CWR58_RS13415	COG0183	Belongs to the thiolase family
CWR58_RS13430	COG1028	Short-chain dehydrogenase reductase Sdr
CWR58_RS13445	COG3842	ATPase activity
CWR58_RS13450	COG1250	3-hydroxyacyl-CoA dehydrogenase
CWR58_RS13450	COG1024	Enoyl-CoA hydratase
CWR58_RS13470	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CWR58_RS13475	COG2137	regulation of response to DNA damage stimulus
CWR58_RS13495	COG0045	succinate-CoA ligase (ADP-forming) activity
CWR58_RS13500	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CWR58_RS13505	COG0861	Integral membrane protein TerC family
CWR58_RS13510	COG0861	Integral membrane protein TerC family
CWR58_RS13555	COG2204	response regulator
CWR58_RS13560	COG2204	response regulator
CWR58_RS13565	COG0028	Belongs to the TPP enzyme family
CWR58_RS13620	COG1028	Short-chain dehydrogenase reductase Sdr
CWR58_RS13630	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
CWR58_RS13635	COG4575	ribosome binding
CWR58_RS13655	COG1546	Belongs to the CinA family
CWR58_RS13655	COG1058	Belongs to the CinA family
CWR58_RS13670	COG0392	lysyltransferase activity
CWR58_RS13680	COG3568	Endonuclease Exonuclease Phosphatase
CWR58_RS13690	COG1695	Transcriptional regulator
CWR58_RS13710	COG0583	DNA-binding transcription factor activity
CWR58_RS13740	COG3181	Tripartite tricarboxylate transporter family receptor
CWR58_RS13745	COG4948	Mandelate Racemase Muconate Lactonizing
CWR58_RS13775	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CWR58_RS13810	COG3005	denitrification pathway
CWR58_RS13815	COG3043	anaerobic respiration
CWR58_RS13835	COG0330	HflC and HflK could
CWR58_RS13860	COG0583	DNA-binding transcription factor activity
CWR58_RS13865	COG1028	Short-chain dehydrogenase reductase Sdr
CWR58_RS13895	COG0431	NADPH-dependent FMN reductase
CWR58_RS13920	COG0824	Thioesterase
CWR58_RS13925	COG1454	alcohol dehydrogenase
CWR58_RS13935	COG1024	Enoyl-CoA hydratase
CWR58_RS13935	COG1250	3-hydroxyacyl-CoA dehydrogenase
CWR58_RS13940	COG3181	Tripartite tricarboxylate transporter family receptor
CWR58_RS13950	COG1024	Enoyl-CoA hydratase
CWR58_RS13960	COG3181	Tripartite tricarboxylate transporter family receptor
CWR58_RS13965	COG0583	DNA-binding transcription factor activity
CWR58_RS13970	COG1028	Short-chain dehydrogenase reductase Sdr
CWR58_RS13985	COG0183	Belongs to the thiolase family
CWR58_RS13990	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CWR58_RS14005	COG3119	arylsulfatase activity
CWR58_RS14020	COG0625	glutathione transferase activity
CWR58_RS14025	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
CWR58_RS14030	COG2944	sequence-specific DNA binding
CWR58_RS14040	COG2197	response regulator
CWR58_RS14060	COG3119	arylsulfatase activity
CWR58_RS14100	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CWR58_RS14115	COG1028	Short-chain dehydrogenase reductase Sdr
CWR58_RS14120	COG0861	Integral membrane protein TerC family
CWR58_RS14145	COG2267	carboxylic ester hydrolase activity
CWR58_RS14150	COG1228	amidohydrolase
CWR58_RS14160	COG0179	Fumarylacetoacetate (FAA) hydrolase
CWR58_RS14170	COG1172	Belongs to the binding-protein-dependent transport system permease family
CWR58_RS14190	COG0583	DNA-binding transcription factor activity
CWR58_RS14195	COG3181	Tripartite tricarboxylate transporter family receptor
CWR58_RS14220	COG2188	Transcriptional regulator
CWR58_RS14230	COG1028	Short-chain dehydrogenase reductase Sdr
CWR58_RS14235	COG1414	Transcriptional regulator
CWR58_RS14250	COG1176	ABC-type spermidine putrescine transport system, permease component I
CWR58_RS14255	COG0395	ABC-type sugar transport system, permease component
CWR58_RS14270	COG0439	Biotin carboxylase
CWR58_RS14275	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CWR58_RS14280	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CWR58_RS14300	COG0833	amino acid
CWR58_RS14330	COG3829	transcription factor binding
CWR58_RS14340	COG4943	cyclic-guanylate-specific phosphodiesterase activity
CWR58_RS14360	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CWR58_RS14365	COG1012	belongs to the aldehyde dehydrogenase family
CWR58_RS14385	COG0583	DNA-binding transcription factor activity
CWR58_RS14390	COG4692	amylo-alpha-1,6-glucosidase activity
CWR58_RS14400	COG0183	Belongs to the thiolase family
CWR58_RS14415	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CWR58_RS14420	COG0633	Ferredoxin
CWR58_RS14430	COG1024	Enoyl-CoA hydratase
CWR58_RS14440	COG4638	Rieske (2fe-2S)
CWR58_RS14445	COG0683	leucine binding
CWR58_RS14450	COG0559	Belongs to the binding-protein-dependent transport system permease family
CWR58_RS14510	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CWR58_RS14520	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CWR58_RS14525	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CWR58_RS14540	COG0330	HflC and HflK could
CWR58_RS14545	COG0330	HflC and HflK could
CWR58_RS14550	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CWR58_RS14555	COG1923	regulation of RNA biosynthetic process
CWR58_RS14565	COG1160	GTP binding
CWR58_RS14570	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CWR58_RS14575	COG2976	Protein conserved in bacteria
CWR58_RS14600	COG0105	UTP biosynthetic process
CWR58_RS14620	COG0642	Histidine kinase
CWR58_RS14630	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CWR58_RS14655	COG0425	Belongs to the sulfur carrier protein TusA family
CWR58_RS14710	COG4172	Belongs to the ABC transporter superfamily
CWR58_RS14715	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CWR58_RS14720	COG0601	transmembrane transport
CWR58_RS14725	COG0747	negative chemotaxis
CWR58_RS14750	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CWR58_RS14800	COG1640	4-alpha-glucanotransferase
CWR58_RS14845	COG0667	Aldo Keto reductase
CWR58_RS14860	COG2259	Doxx family
CWR58_RS14900	COG0386	Belongs to the glutathione peroxidase family
CWR58_RS14905	COG0625	glutathione transferase activity
CWR58_RS14920	COG0095	Lipoate-protein ligase
CWR58_RS14935	COG0688	phosphatidylethanolamine metabolic process
CWR58_RS14945	COG1464	Belongs to the NlpA lipoprotein family
CWR58_RS14960	COG2363	Small membrane protein
CWR58_RS14985	COG2133	pyrroloquinoline quinone binding
CWR58_RS14990	COG0625	glutathione transferase activity
CWR58_RS14995	COG1794	racemase activity, acting on amino acids and derivatives
CWR58_RS15015	COG0559	Belongs to the binding-protein-dependent transport system permease family
CWR58_RS15025	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
CWR58_RS15035	COG1653	transport
CWR58_RS15040	COG1175	transmembrane transport
CWR58_RS15045	COG0395	ABC-type sugar transport system, permease component
CWR58_RS15065	COG1028	Short-chain dehydrogenase reductase Sdr
CWR58_RS15065	COG3321	synthase
CWR58_RS15065	COG0604	alcohol dehydrogenase
CWR58_RS15080	COG0300	oxidoreductase activity
CWR58_RS15100	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CWR58_RS15115	COG0438	transferase activity, transferring glycosyl groups
CWR58_RS15135	COG0463	Glycosyl transferase, family 2
CWR58_RS15150	COG0783	Belongs to the Dps family
CWR58_RS15165	COG0583	DNA-binding transcription factor activity
CWR58_RS15170	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CWR58_RS15185	COG0656	L-ascorbic acid biosynthetic process
CWR58_RS15190	COG2814	Major facilitator Superfamily
CWR58_RS15195	COG0583	DNA-binding transcription factor activity
CWR58_RS15205	COG1840	ABC-type Fe3 transport system, periplasmic component
CWR58_RS15215	COG3842	ATPase activity
CWR58_RS15220	COG1741	Belongs to the pirin family
CWR58_RS15225	COG1741	Belongs to the pirin family
CWR58_RS15230	COG0583	DNA-binding transcription factor activity
CWR58_RS15235	COG2204	response regulator
CWR58_RS15245	COG0174	glutamine synthetase
CWR58_RS15250	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CWR58_RS15260	COG5001	Diguanylate cyclase
CWR58_RS15260	COG5002	protein histidine kinase activity
CWR58_RS15305	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CWR58_RS15310	COG0791	NLP P60 protein
CWR58_RS15315	COG1028	Short-chain dehydrogenase reductase Sdr
CWR58_RS15320	COG2863	cytochrome
CWR58_RS15325	COG3258	Cytochrome c
CWR58_RS15330	COG0194	GDP metabolic process
CWR58_RS15335	COG1758	RNA polymerase activity
CWR58_RS15340	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CWR58_RS15345	COG1126	abc transporter atp-binding protein
CWR58_RS15350	COG0765	amino acid transport
CWR58_RS15355	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CWR58_RS15375	COG0583	DNA-binding transcription factor activity
CWR58_RS15400	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CWR58_RS15415	COG2831	hemolysin activation secretion protein
CWR58_RS15420	COG3539	Fimbrial protein
CWR58_RS15425	COG3188	usher protein
CWR58_RS15430	COG3121	Chaperone
CWR58_RS15440	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
CWR58_RS15440	COG3064	Membrane
CWR58_RS15440	COG3210	domain, Protein
CWR58_RS15445	COG2197	response regulator
CWR58_RS15500	COG4181	ATPase activity
CWR58_RS15510	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CWR58_RS15515	COG0584	glycerophosphoryl diester phosphodiesterase
CWR58_RS15520	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
CWR58_RS15530	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CWR58_RS15530	COG0678	peroxiredoxin activity
CWR58_RS15540	COG0789	Transcriptional regulator
CWR58_RS15580	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CWR58_RS15590	COG2252	PERMEase
CWR58_RS15595	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CWR58_RS15600	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CWR58_RS15630	COG0488	(ABC) transporter
CWR58_RS15635	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CWR58_RS15645	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CWR58_RS15650	COG1024	Enoyl-CoA hydratase
CWR58_RS15655	COG1619	proteins homologs of microcin C7 resistance protein MccF
CWR58_RS15660	COG0590	tRNA wobble adenosine to inosine editing
CWR58_RS15680	COG2212	antiporter activity
CWR58_RS15685	COG1863	multisubunit Na H antiporter MnhE subunit
CWR58_RS15690	COG0651	ATP synthesis coupled electron transport
CWR58_RS15695	COG1006	Multisubunit Na H antiporter MnhC subunit
CWR58_RS15700	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CWR58_RS15700	COG2111	Na H antiporter
CWR58_RS15715	COG0420	3'-5' exonuclease activity
CWR58_RS15750	COG0395	ABC-type sugar transport system, permease component
CWR58_RS15760	COG3842	ATPase activity
CWR58_RS15790	COG3181	Tripartite tricarboxylate transporter family receptor
CWR58_RS15795	COG1053	succinate dehydrogenase
CWR58_RS15795	COG3976	FMN-binding domain protein
CWR58_RS15825	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CWR58_RS15855	COG0450	alkyl hydroperoxide reductase
CWR58_RS15860	COG1960	acyl-CoA dehydrogenase activity
CWR58_RS15875	COG0123	including yeast histone deacetylase and acetoin utilization protein
CWR58_RS15880	COG2951	lytic endotransglycosylase activity
CWR58_RS15900	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CWR58_RS15905	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
CWR58_RS15935	COG0287	Prephenate dehydrogenase
CWR58_RS15970	COG2814	Major facilitator Superfamily
CWR58_RS16040	COG0583	DNA-binding transcription factor activity
CWR58_RS16055	COG0179	Fumarylacetoacetate (FAA) hydrolase
CWR58_RS16080	COG1053	succinate dehydrogenase
CWR58_RS16085	COG1012	belongs to the aldehyde dehydrogenase family
CWR58_RS16090	COG2079	MmgE PrpD family protein
CWR58_RS16100	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CWR58_RS16125	COG0028	Belongs to the TPP enzyme family
CWR58_RS16125	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
CWR58_RS16130	COG0436	Aminotransferase
CWR58_RS16150	COG0778	Nitroreductase
CWR58_RS16155	COG2814	Major facilitator Superfamily
CWR58_RS16160	COG3706	GGDEF domain
CWR58_RS16165	COG0589	response to stress
CWR58_RS16175	COG2951	lytic endotransglycosylase activity
CWR58_RS16180	COG2833	Protein of unknown function (DUF455)
CWR58_RS16195	COG1132	(ABC) transporter
CWR58_RS16205	COG1181	Belongs to the D-alanine--D-alanine ligase family
CWR58_RS16205	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CWR58_RS16210	COG3237	CsbD-like
CWR58_RS16220	COG2823	Periplasmic or secreted lipoprotein
CWR58_RS16240	COG0672	)-iron permease
CWR58_RS16255	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
CWR58_RS16260	COG1028	Short-chain dehydrogenase reductase Sdr
CWR58_RS16265	COG3243	poly(R)-hydroxyalkanoic acid synthase
CWR58_RS16275	COG0564	pseudouridine synthase activity
CWR58_RS16285	COG1199	ATP-dependent helicase activity
CWR58_RS16290	COG2183	response to ionizing radiation
CWR58_RS16315	COG4774	siderophore transport
CWR58_RS16325	COG1595	DNA-templated transcription, initiation
CWR58_RS16330	COG2175	clavaminate synthase activity
CWR58_RS16340	COG3181	Tripartite tricarboxylate transporter family receptor
CWR58_RS16345	COG0583	DNA-binding transcription factor activity
CWR58_RS16350	COG1028	Short-chain dehydrogenase reductase Sdr
CWR58_RS16355	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
CWR58_RS16360	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CWR58_RS16365	COG0508	dehydrogenase complex catalyzes the overall conversion of
CWR58_RS16370	COG0567	Dehydrogenase, E1 component
CWR58_RS16380	COG1522	sequence-specific DNA binding
CWR58_RS16390	COG0281	malic enzyme
CWR58_RS16390	COG0280	phosphate acetyltransferase
CWR58_RS16395	COG3539	Fimbrial protein
CWR58_RS16410	COG0372	Belongs to the citrate synthase family
CWR58_RS16415	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
CWR58_RS16420	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CWR58_RS16425	COG1053	succinate dehydrogenase
CWR58_RS16430	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
CWR58_RS16435	COG2009	succinate dehydrogenase
CWR58_RS16440	COG2188	Transcriptional regulator
CWR58_RS16445	COG0039	L-malate dehydrogenase activity
CWR58_RS16465	COG2828	Protein conserved in bacteria
CWR58_RS16475	COG1981	membrane
CWR58_RS16500	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CWR58_RS16510	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CWR58_RS16545	COG0148	phosphopyruvate hydratase activity
CWR58_RS16555	COG2877	3-deoxy-8-phosphooctulonate synthase activity
CWR58_RS16560	COG0504	CTP synthase activity
CWR58_RS16580	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CWR58_RS16590	COG0747	negative chemotaxis
CWR58_RS16595	COG4172	Belongs to the ABC transporter superfamily
CWR58_RS16600	COG1446	asparaginase
CWR58_RS16630	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CWR58_RS16645	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
CWR58_RS16650	COG0697	spore germination
CWR58_RS16655	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CWR58_RS16665	COG3193	protein, possibly involved in utilization of glycolate and propanediol
CWR58_RS16670	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CWR58_RS16675	COG0791	NLP P60 protein
CWR58_RS16685	COG0583	DNA-binding transcription factor activity
CWR58_RS16700	COG0583	DNA-binding transcription factor activity
CWR58_RS16725	COG0670	Belongs to the BI1 family
CWR58_RS16730	COG3181	Tripartite tricarboxylate transporter family receptor
CWR58_RS16740	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CWR58_RS16750	COG1381	Involved in DNA repair and RecF pathway recombination
CWR58_RS16755	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CWR58_RS16760	COG0571	ribonuclease III activity
CWR58_RS16765	COG0681	Belongs to the peptidase S26 family
CWR58_RS16775	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CWR58_RS16800	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CWR58_RS16805	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CWR58_RS16830	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CWR58_RS16835	COG1399	metal-binding, possibly nucleic acid-binding protein
CWR58_RS16850	COG3023	N-Acetylmuramoyl-L-alanine amidase
CWR58_RS16860	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CWR58_RS16865	COG0546	phosphoglycolate phosphatase activity
CWR58_RS16875	COG1530	ribonuclease E activity
CWR58_RS16885	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CWR58_RS16890	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CWR58_RS16915	COG3228	Belongs to the MtfA family
CWR58_RS16925	COG0251	oxidation-reduction process
CWR58_RS16935	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CWR58_RS16950	COG2878	Part of a membrane complex involved in electron transport
CWR58_RS16955	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CWR58_RS16990	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CWR58_RS17015	COG1268	BioY protein
CWR58_RS17020	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CWR58_RS17025	COG1122	ATPase activity
CWR58_RS17030	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CWR58_RS17040	COG0271	Belongs to the BolA IbaG family
CWR58_RS17045	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CWR58_RS17060	COG1196	nuclear chromosome segregation
CWR58_RS17065	COG0477	Major facilitator Superfamily
CWR58_RS17070	COG1573	uracil-dna glycosylase
CWR58_RS17075	COG1214	PFAM Peptidase M22, glycoprotease
CWR58_RS17090	COG0450	alkyl hydroperoxide reductase
CWR58_RS17095	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CWR58_RS17110	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CWR58_RS17120	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CWR58_RS17125	COG0560	Phosphoserine phosphatase
CWR58_RS17130	COG0583	DNA-binding transcription factor activity
CWR58_RS17135	COG3181	Tripartite tricarboxylate transporter family receptor
CWR58_RS17140	COG0028	Belongs to the TPP enzyme family
CWR58_RS17165	COG4774	siderophore transport
CWR58_RS17175	COG1007	ATP synthesis coupled electron transport
CWR58_RS17190	COG0713	ATP synthesis coupled electron transport
CWR58_RS17200	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CWR58_RS17205	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CWR58_RS17210	COG1034	ATP synthesis coupled electron transport
CWR58_RS17220	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
CWR58_RS17235	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CWR58_RS17240	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CWR58_RS17245	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CWR58_RS17265	COG0671	phosphoesterase, PA-phosphatase related
CWR58_RS17275	COG1597	lipid kinase activity
CWR58_RS17280	COG0583	DNA-binding transcription factor activity
CWR58_RS17285	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CWR58_RS17290	COG1733	regulation of RNA biosynthetic process
CWR58_RS17295	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CWR58_RS17315	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
CWR58_RS17335	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CWR58_RS17355	COG3608	succinylglutamate desuccinylase aspartoacylase
CWR58_RS17360	COG0626	cystathionine gamma-synthase activity
CWR58_RS17365	COG0583	DNA-binding transcription factor activity
CWR58_RS17375	COG3181	Tripartite tricarboxylate transporter family receptor
CWR58_RS17380	COG0165	Argininosuccinate lyase
CWR58_RS17395	COG3799	methylaspartate ammonia-lyase activity
CWR58_RS17405	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CWR58_RS17415	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CWR58_RS17420	COG0149	triose-phosphate isomerase activity
CWR58_RS17440	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CWR58_RS17450	COG1185	polyribonucleotide nucleotidyltransferase activity
CWR58_RS17455	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CWR58_RS17470	COG1183	phosphatidylcholine synthase activity
CWR58_RS17480	COG0440	acetolactate synthase activity
CWR58_RS17485	COG0028	Belongs to the TPP enzyme family
CWR58_RS17490	COG1289	transmembrane transporter activity
CWR58_RS17500	COG3022	response to hydroperoxide
CWR58_RS17505	COG1028	Short-chain dehydrogenase reductase Sdr
CWR58_RS17520	COG3486	L-lysine 6-monooxygenase (NADPH) activity
CWR58_RS17550	COG2814	Major facilitator Superfamily
CWR58_RS17570	COG3706	GGDEF domain
CWR58_RS17605	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CWR58_RS17615	COG1674	ftsk spoiiie
CWR58_RS17620	COG0492	ferredoxin-NADP+ reductase activity
CWR58_RS17625	COG1193	negative regulation of DNA recombination
CWR58_RS17635	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CWR58_RS17655	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
CWR58_RS17660	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
CWR58_RS17665	COG2205	protein histidine kinase activity
CWR58_RS17670	COG0745	RESPONSE REGULATOR receiver
CWR58_RS17705	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CWR58_RS17725	COG0612	Peptidase, M16
CWR58_RS17745	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CWR58_RS17760	COG1420	regulation of RNA biosynthetic process
CWR58_RS17770	COG0497	DNA recombination
CWR58_RS17780	COG0735	belongs to the Fur family
CWR58_RS17785	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CWR58_RS17830	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CWR58_RS17830	COG0446	pyridine nucleotide-disulphide oxidoreductase
CWR58_RS17835	COG4311	Sarcosine oxidase, delta subunit
CWR58_RS17840	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CWR58_RS17850	COG0583	DNA-binding transcription factor activity
CWR58_RS17870	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CWR58_RS17875	COG2030	dehydratase
CWR58_RS17885	COG1024	Enoyl-CoA hydratase
CWR58_RS17910	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CWR58_RS17920	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CWR58_RS17920	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CWR58_RS17935	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CWR58_RS17950	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CWR58_RS17960	COG0405	Gamma-glutamyltransferase
CWR58_RS17975	COG1280	lysine exporter protein (LysE YggA)
CWR58_RS18005	COG0583	DNA-binding transcription factor activity
CWR58_RS18045	COG1414	Transcriptional regulator
CWR58_RS18050	COG1546	Belongs to the CinA family
CWR58_RS18050	COG1058	Belongs to the CinA family
CWR58_RS18065	COG0513	Belongs to the DEAD box helicase family
CWR58_RS18095	COG0429	hydrolase of the alpha beta-hydrolase fold
CWR58_RS18100	COG4783	chaperone-mediated protein folding
CWR58_RS18115	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CWR58_RS18130	COG0006	proline dipeptidase activity
CWR58_RS18140	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CWR58_RS18185	COG0514	ATP-dependent DNA helicase (RecQ)
CWR58_RS18210	COG1271	oxidase subunit
CWR58_RS18225	COG2894	cell division
CWR58_RS18230	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CWR58_RS18245	COG0488	(ABC) transporter
CWR58_RS18270	COG4608	Belongs to the ABC transporter superfamily
CWR58_RS18275	COG0444	Belongs to the ABC transporter superfamily
CWR58_RS18280	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CWR58_RS18285	COG0601	transmembrane transport
CWR58_RS18295	COG1215	transferase activity, transferring glycosyl groups
CWR58_RS18310	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CWR58_RS18320	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CWR58_RS18335	COG0318	PFAM AMP-dependent synthetase and ligase
CWR58_RS18340	COG2188	Transcriptional regulator
CWR58_RS18345	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CWR58_RS18350	COG2814	Major facilitator Superfamily
CWR58_RS18360	COG0259	pyridoxamine-phosphate oxidase activity
CWR58_RS18365	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CWR58_RS18380	COG0583	DNA-binding transcription factor activity
CWR58_RS18385	COG1960	acyl-CoA dehydrogenase activity
CWR58_RS18395	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CWR58_RS18400	COG0405	Gamma-glutamyltransferase
CWR58_RS18410	COG3181	Tripartite tricarboxylate transporter family receptor
CWR58_RS18425	COG0802	atpase or kinase
CWR58_RS18430	COG0860	N-Acetylmuramoyl-L-alanine amidase
CWR58_RS18435	COG0586	Pfam SNARE associated Golgi protein
CWR58_RS18465	COG0617	tRNA 3'-terminal CCA addition
CWR58_RS18490	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CWR58_RS18495	COG2188	Transcriptional regulator
CWR58_RS18505	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CWR58_RS18510	COG1234	tRNA 3'-trailer cleavage
CWR58_RS18515	COG1028	Short-chain dehydrogenase reductase Sdr
CWR58_RS18525	COG1028	Short-chain dehydrogenase reductase Sdr
CWR58_RS18530	COG3181	Tripartite tricarboxylate transporter family receptor
CWR58_RS18535	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CWR58_RS18540	COG2301	Belongs to the HpcH HpaI aldolase family
CWR58_RS18545	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CWR58_RS18550	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
CWR58_RS18560	COG1024	Enoyl-CoA hydratase
CWR58_RS18570	COG2188	Transcriptional regulator
CWR58_RS18575	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CWR58_RS18580	COG0066	3-isopropylmalate dehydratase activity
CWR58_RS18595	COG0752	glycyl-tRNA synthetase alpha subunit
CWR58_RS18600	COG0751	glycine-tRNA ligase activity
CWR58_RS18605	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CWR58_RS18610	COG0204	Acyl-transferase
CWR58_RS18625	COG0242	peptide deformylase activity
CWR58_RS18630	COG1960	acyl-CoA dehydrogenase activity
CWR58_RS18635	COG0700	Nucleoside recognition
CWR58_RS18640	COG0469	pyruvate kinase activity
CWR58_RS18670	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CWR58_RS18680	COG2154	pterin-4-alpha-carbinolamine dehydratase
CWR58_RS18700	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CWR58_RS18705	COG0154	amidase activity
CWR58_RS18715	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CWR58_RS18725	COG0747	negative chemotaxis
CWR58_RS18740	COG0019	diaminopimelate decarboxylase activity
CWR58_RS18755	COG3712	iron ion homeostasis
CWR58_RS18760	COG4774	siderophore transport
CWR58_RS18765	COG2353	YceI-like domain
CWR58_RS18770	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CWR58_RS18785	COG0583	DNA-binding transcription factor activity
CWR58_RS18805	COG3384	dioxygenase
CWR58_RS18810	COG0179	Fumarylacetoacetate (FAA) hydrolase
CWR58_RS18845	COG1028	Short-chain dehydrogenase reductase Sdr
CWR58_RS18850	COG1309	transcriptional regulator
CWR58_RS18855	COG2982	Protein involved in outer membrane biogenesis
CWR58_RS18860	COG2818	Glycosylase
CWR58_RS18880	COG1653	transport
CWR58_RS18885	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CWR58_RS18890	COG3842	ATPase activity
CWR58_RS18895	COG0395	ABC-type sugar transport system, permease component
CWR58_RS18920	COG2186	Transcriptional regulator
CWR58_RS18940	COG1454	alcohol dehydrogenase
CWR58_RS18955	COG2011	ABC-type metal ion transport system permease component
CWR58_RS18960	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CWR58_RS18965	COG1501	Belongs to the glycosyl hydrolase 31 family
CWR58_RS18980	COG0318	PFAM AMP-dependent synthetase and ligase
CWR58_RS18985	COG1473	amidohydrolase
CWR58_RS18995	COG2855	membrane
CWR58_RS19005	COG2239	Acts as a magnesium transporter
CWR58_RS19020	COG1522	sequence-specific DNA binding
CWR58_RS19025	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CWR58_RS19030	COG1028	Short-chain dehydrogenase reductase Sdr
CWR58_RS19055	COG0739	heme binding
CWR58_RS19065	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
CWR58_RS19070	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CWR58_RS19080	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CWR58_RS19085	COG1181	Belongs to the D-alanine--D-alanine ligase family
CWR58_RS19110	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CWR58_RS19115	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CWR58_RS19125	COG3116	cell division
CWR58_RS19130	COG0275	rRNA processing
CWR58_RS19135	COG2001	Belongs to the MraZ family
CWR58_RS19145	COG0488	(ABC) transporter
CWR58_RS19150	COG0418	dihydroorotase activity
CWR58_RS19155	COG1473	amidohydrolase
CWR58_RS19205	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CWR58_RS19210	COG4654	Cytochrome c, class I
CWR58_RS19265	COG2084	Dehydrogenase
CWR58_RS19310	COG0824	Thioesterase
CWR58_RS19315	COG0811	peptide transport
CWR58_RS19320	COG0848	biopolymer transport protein
CWR58_RS19345	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CWR58_RS19350	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CWR58_RS19355	COG3181	Tripartite tricarboxylate transporter family receptor
CWR58_RS19370	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CWR58_RS19395	COG0183	Belongs to the thiolase family
CWR58_RS19405	COG1960	acyl-CoA dehydrogenase activity
CWR58_RS19410	COG0583	DNA-binding transcription factor activity
CWR58_RS19415	COG3181	Tripartite tricarboxylate transporter family receptor
CWR58_RS19420	COG1024	Enoyl-CoA hydratase
CWR58_RS19430	COG1253	flavin adenine dinucleotide binding
CWR58_RS19435	COG1285	pathogenesis
CWR58_RS19460	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CWR58_RS19465	COG0697	spore germination
CWR58_RS19475	COG1073	alpha beta
CWR58_RS19500	COG0463	Glycosyl transferase, family 2
CWR58_RS19510	COG0786	glutamate:sodium symporter activity
CWR58_RS19520	COG2031	fatty acid transporter
CWR58_RS19535	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CWR58_RS19540	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CWR58_RS19550	COG0328	RNA-DNA hybrid ribonuclease activity
CWR58_RS19555	COG2226	methyltransferase
CWR58_RS19560	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CWR58_RS19565	COG0741	lytic transglycosylase activity
CWR58_RS19565	COG1388	LysM domain
CWR58_RS19580	COG2979	Protein of unknown function (DUF533)
CWR58_RS19600	COG3181	Tripartite tricarboxylate transporter family receptor
CWR58_RS19615	COG3119	arylsulfatase activity
CWR58_RS19640	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CWR58_RS19660	COG0832	Belongs to the urease beta subunit family
CWR58_RS19670	COG0831	urea catabolic process
CWR58_RS19675	COG0829	nickel cation binding
CWR58_RS19690	COG0633	Ferredoxin
CWR58_RS19705	COG2188	Transcriptional regulator
CWR58_RS19710	COG3799	methylaspartate ammonia-lyase activity
CWR58_RS19730	COG2719	SpoVR family
CWR58_RS19735	COG2718	Belongs to the UPF0229 family
CWR58_RS19740	COG2766	serine protein kinase
CWR58_RS19745	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CWR58_RS19745	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CWR58_RS19755	COG4977	sequence-specific DNA binding
CWR58_RS19760	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CWR58_RS19790	COG0316	Belongs to the HesB IscA family
CWR58_RS19810	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CWR58_RS19815	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CWR58_RS19820	COG0312	modulator of DNA gyrase
CWR58_RS19840	COG1116	anion transmembrane transporter activity
CWR58_RS19845	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CWR58_RS19850	COG1335	isochorismatase
CWR58_RS19855	COG0346	lactoylglutathione lyase activity
CWR58_RS19860	COG0513	Belongs to the DEAD box helicase family
CWR58_RS19870	COG1802	Transcriptional regulator
CWR58_RS19875	COG0045	succinate-CoA ligase (ADP-forming) activity
CWR58_RS19875	COG1042	CoA-binding domain protein
CWR58_RS19875	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CWR58_RS19895	COG1522	sequence-specific DNA binding
CWR58_RS19925	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CWR58_RS19930	COG1696	Membrane protein involved in D-alanine export
CWR58_RS19955	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CWR58_RS19970	COG0439	Biotin carboxylase
CWR58_RS19975	COG0511	ligase activity, forming carbon-carbon bonds
CWR58_RS19980	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CWR58_RS19985	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CWR58_RS19990	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CWR58_RS19995	COG3150	esterase
CWR58_RS20000	COG0557	exoribonuclease II activity
CWR58_RS20015	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CWR58_RS20050	COG1678	Uncharacterized ACR, COG1678
CWR58_RS20065	COG0352	thiamine-phosphate diphosphorylase activity
CWR58_RS20095	COG1960	acyl-CoA dehydrogenase activity
CWR58_RS20105	COG1028	Short-chain dehydrogenase reductase Sdr
CWR58_RS20165	COG0494	nUDIX hydrolase
CWR58_RS20190	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
CWR58_RS20215	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CWR58_RS20220	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CWR58_RS20250	COG1126	abc transporter atp-binding protein
CWR58_RS20255	COG0765	amino acid transport
CWR58_RS20260	COG4597	amino acid ABC transporter
CWR58_RS20265	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CWR58_RS20270	COG2884	Cell division ATP-binding protein ftsE
CWR58_RS20275	COG2177	Part of the ABC transporter FtsEX involved in
CWR58_RS20290	COG1194	a g-specific adenine glycosylase
CWR58_RS20310	COG4206	TonB-dependent receptor
CWR58_RS20315	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CWR58_RS20325	COG0351	phosphomethylpyrimidine kinase
CWR58_RS20330	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CWR58_RS20340	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CWR58_RS20350	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CWR58_RS20365	COG2226	methyltransferase
CWR58_RS20370	COG0745	RESPONSE REGULATOR receiver
CWR58_RS20375	COG5002	protein histidine kinase activity
CWR58_RS20385	COG5002	protein histidine kinase activity
CWR58_RS20395	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CWR58_RS20400	COG0583	DNA-binding transcription factor activity
CWR58_RS20410	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CWR58_RS20415	COG1984	allophanate hydrolase subunit 2
CWR58_RS20430	COG3181	Tripartite tricarboxylate transporter family receptor
CWR58_RS20440	COG1024	Enoyl-CoA hydratase
CWR58_RS20455	COG1802	Transcriptional regulator
CWR58_RS20465	COG1238	metal cluster binding
CWR58_RS20470	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CWR58_RS20475	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CWR58_RS20495	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
CWR58_RS20500	COG4988	ABC transporter
CWR58_RS20510	COG1294	oxidase, subunit
CWR58_RS20535	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
CWR58_RS20550	COG1137	ATPase activity
CWR58_RS20555	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CWR58_RS20570	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CWR58_RS20570	COG2010	Cytochrome c
CWR58_RS20580	COG1660	Displays ATPase and GTPase activities
CWR58_RS20590	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CWR58_RS20605	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CWR58_RS20610	COG2823	Periplasmic or secreted lipoprotein
CWR58_RS20640	COG0471	metal ion transport
CWR58_RS20645	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
CWR58_RS20650	COG0772	Belongs to the SEDS family
CWR58_RS20655	COG0768	penicillin binding
CWR58_RS20665	COG1792	Involved in formation and maintenance of cell shape
CWR58_RS20670	COG1077	Cell shape determining protein MreB Mrl
CWR58_RS20695	COG0708	Exodeoxyribonuclease III
CWR58_RS20705	COG2860	membrane
CWR58_RS20715	COG0583	DNA-binding transcription factor activity
CWR58_RS20720	COG0473	3-isopropylmalate dehydrogenase activity
CWR58_RS20745	COG0583	DNA-binding transcription factor activity
CWR58_RS20750	COG2515	1-aminocyclopropane-1-carboxylate deaminase
CWR58_RS20755	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CWR58_RS20760	COG0765	amino acid transport
CWR58_RS20765	COG0765	amino acid transport
CWR58_RS20770	COG1126	abc transporter atp-binding protein
CWR58_RS20775	COG1794	racemase activity, acting on amino acids and derivatives
CWR58_RS20780	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CWR58_RS20785	COG2223	nitrite transmembrane transporter activity
CWR58_RS20790	COG2813	Specifically methylates the guanine in position
CWR58_RS20790	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CWR58_RS20800	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
CWR58_RS20845	COG0583	DNA-binding transcription factor activity
CWR58_RS20850	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CWR58_RS20855	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CWR58_RS20890	COG0154	amidase activity
CWR58_RS20900	COG1414	Transcriptional regulator
CWR58_RS20910	COG1250	3-hydroxyacyl-CoA dehydrogenase
CWR58_RS20910	COG1024	Enoyl-CoA hydratase
CWR58_RS20920	COG2132	Multicopper oxidase
CWR58_RS20965	COG1024	Enoyl-CoA hydratase
CWR58_RS20970	COG1024	Enoyl-CoA hydratase
CWR58_RS20975	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CWR58_RS20985	COG0747	negative chemotaxis
CWR58_RS20995	COG0601	transmembrane transport
CWR58_RS21000	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CWR58_RS21005	COG0444	Belongs to the ABC transporter superfamily
CWR58_RS21010	COG4608	Belongs to the ABC transporter superfamily
CWR58_RS21020	COG2195	Cleaves the N-terminal amino acid of tripeptides
CWR58_RS21025	COG0210	DNA helicase
CWR58_RS21030	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CWR58_RS21045	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CWR58_RS21065	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CWR58_RS21080	COG0356	it plays a direct role in the translocation of protons across the membrane
CWR58_RS21095	COG1024	Enoyl-CoA hydratase
CWR58_RS21120	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CWR58_RS21130	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CWR58_RS21135	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
CWR58_RS21140	COG2967	ApaG domain
CWR58_RS21145	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CWR58_RS21150	COG0546	phosphoglycolate phosphatase activity
CWR58_RS21160	COG0512	Glutamine amidotransferase of anthranilate synthase
CWR58_RS21175	COG1028	Short-chain dehydrogenase reductase Sdr
CWR58_RS21195	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CWR58_RS21205	COG1607	acyl-coa hydrolase
CWR58_RS21260	COG1802	Transcriptional regulator
CWR58_RS21290	COG1595	DNA-templated transcription, initiation
CWR58_RS21305	COG3720	iron ion transport
CWR58_RS21310	COG4558	Periplasmic binding protein
CWR58_RS21315	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CWR58_RS21325	COG1683	Conserved Protein
CWR58_RS21355	COG3064	Membrane
CWR58_RS21360	COG0583	DNA-binding transcription factor activity
CWR58_RS21370	COG1234	tRNA 3'-trailer cleavage
CWR58_RS21380	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CWR58_RS21385	COG1802	Transcriptional regulator
CWR58_RS21395	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CWR58_RS21415	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CWR58_RS21435	COG3181	Tripartite tricarboxylate transporter family receptor
CWR58_RS21440	COG0583	DNA-binding transcription factor activity
CWR58_RS21450	COG1522	sequence-specific DNA binding
CWR58_RS21455	COG0183	Belongs to the thiolase family
CWR58_RS21515	COG2814	Major facilitator Superfamily
CWR58_RS21540	COG1999	signal sequence binding
CWR58_RS21585	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CWR58_RS21605	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CWR58_RS21615	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CWR58_RS21625	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
CWR58_RS21630	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
CWR58_RS21640	COG0067	glutamate synthase
CWR58_RS21640	COG0070	glutamate synthase
CWR58_RS21640	COG0069	glutamate synthase activity
CWR58_RS21650	COG3047	cAMP biosynthetic process
CWR58_RS21660	COG1127	ABC transporter
CWR58_RS21665	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CWR58_RS21670	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CWR58_RS21675	COG2853	Lipoprotein
CWR58_RS21685	COG1131	(ABC) transporter
CWR58_RS21690	COG0842	Transport permease protein
CWR58_RS21710	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CWR58_RS21720	COG0131	Imidazoleglycerol-phosphate dehydratase
CWR58_RS21730	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CWR58_RS21745	COG0140	phosphoribosyl-ATP diphosphatase activity
CWR58_RS21750	COG0537	adenosine 5'-monophosphoramidase activity
CWR58_RS21755	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CWR58_RS21780	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CWR58_RS21790	COG0723	plastoquinol--plastocyanin reductase activity
CWR58_RS21795	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CWR58_RS21800	COG2857	Cytochrome c1
CWR58_RS21805	COG0625	glutathione transferase activity
CWR58_RS21810	COG2969	positive regulation of protein catabolic process
CWR58_RS21840	COG0583	DNA-binding transcription factor activity
CWR58_RS21845	COG0492	ferredoxin-NADP+ reductase activity
CWR58_RS21865	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CWR58_RS21875	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CWR58_RS21890	COG3181	Tripartite tricarboxylate transporter family receptor
CWR58_RS21925	COG3702	type iv secretory pathway
CWR58_RS21945	COG3736	Type IV secretory pathway, component VirB8
CWR58_RS21960	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
CWR58_RS21970	COG0697	spore germination
CWR58_RS21990	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CWR58_RS21995	COG0747	negative chemotaxis
CWR58_RS22000	COG0601	transmembrane transport
CWR58_RS22005	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CWR58_RS22015	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
CWR58_RS22025	COG0513	Belongs to the DEAD box helicase family
CWR58_RS22030	COG1280	lysine exporter protein (LysE YggA)
CWR58_RS22055	COG0583	DNA-binding transcription factor activity
CWR58_RS22065	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CWR58_RS22075	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CWR58_RS22080	COG0154	amidase activity
CWR58_RS22085	COG1609	Transcriptional regulator
CWR58_RS22105	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CWR58_RS22110	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CWR58_RS22115	COG3842	ATPase activity
CWR58_RS22120	COG1653	transport
CWR58_RS22125	COG1175	transmembrane transport
CWR58_RS22130	COG0395	ABC-type sugar transport system, permease component
CWR58_RS22165	COG1280	lysine exporter protein (LysE YggA)
CWR58_RS22180	COG1960	acyl-CoA dehydrogenase activity
CWR58_RS22190	COG0183	Belongs to the thiolase family
CWR58_RS22195	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CWR58_RS22215	COG3181	Tripartite tricarboxylate transporter family receptor
CWR58_RS22225	COG2358	TRAP transporter, solute receptor (TAXI family
CWR58_RS22240	COG2922	Belongs to the Smg family
CWR58_RS22265	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
CWR58_RS22270	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CWR58_RS22275	COG1028	Short-chain dehydrogenase reductase Sdr
CWR58_RS22280	COG1012	belongs to the aldehyde dehydrogenase family
CWR58_RS22290	COG0028	Belongs to the TPP enzyme family
CWR58_RS22295	COG1522	sequence-specific DNA binding
CWR58_RS22300	COG3781	membrane
CWR58_RS22330	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CWR58_RS22355	COG1304	FMN binding
CWR58_RS22375	COG1414	Transcriptional regulator
CWR58_RS22390	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CWR58_RS22395	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CWR58_RS22400	COG0594	ribonuclease P activity
CWR58_RS22405	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CWR58_RS22415	COG0753	catalase activity
CWR58_RS22420	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CWR58_RS22425	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
CWR58_RS22435	COG2175	clavaminate synthase activity
CWR58_RS22440	COG1473	amidohydrolase
CWR58_RS22445	COG4608	Belongs to the ABC transporter superfamily
CWR58_RS22450	COG0444	Belongs to the ABC transporter superfamily
CWR58_RS22460	COG0601	transmembrane transport
CWR58_RS22465	COG0747	negative chemotaxis
CWR58_RS22505	COG0436	Aminotransferase
CWR58_RS22510	COG1278	Cold shock