locus-tag	class	description
E0718_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E0718_RS00020	COG1414	Transcriptional regulator
E0718_RS00040	COG1304	FMN binding
E0718_RS00065	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
E0718_RS00095	COG3781	membrane
E0718_RS00100	COG1522	sequence-specific DNA binding
E0718_RS00105	COG0028	Belongs to the TPP enzyme family
E0718_RS00115	COG1012	belongs to the aldehyde dehydrogenase family
E0718_RS00120	COG1028	Short-chain dehydrogenase reductase Sdr
E0718_RS00125	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E0718_RS00130	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
E0718_RS00155	COG2922	Belongs to the Smg family
E0718_RS00170	COG2358	TRAP transporter, solute receptor (TAXI family
E0718_RS00180	COG3181	Tripartite tricarboxylate transporter family receptor
E0718_RS00200	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E0718_RS00205	COG0183	Belongs to the thiolase family
E0718_RS00215	COG1960	acyl-CoA dehydrogenase activity
E0718_RS00230	COG1280	lysine exporter protein (LysE YggA)
E0718_RS00265	COG0395	ABC-type sugar transport system, permease component
E0718_RS00270	COG1175	transmembrane transport
E0718_RS00275	COG1653	transport
E0718_RS00280	COG3842	ATPase activity
E0718_RS00285	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
E0718_RS00290	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
E0718_RS00310	COG1609	Transcriptional regulator
E0718_RS00315	COG0154	amidase activity
E0718_RS00320	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E0718_RS00330	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
E0718_RS00340	COG0583	DNA-binding transcription factor activity
E0718_RS00365	COG1280	lysine exporter protein (LysE YggA)
E0718_RS00370	COG0513	Belongs to the DEAD box helicase family
E0718_RS00380	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
E0718_RS00390	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E0718_RS00395	COG0601	transmembrane transport
E0718_RS00400	COG0747	negative chemotaxis
E0718_RS00405	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
E0718_RS00425	COG0697	spore germination
E0718_RS00435	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
E0718_RS00450	COG3736	Type IV secretory pathway, component VirB8
E0718_RS00470	COG3702	type iv secretory pathway
E0718_RS00505	COG3181	Tripartite tricarboxylate transporter family receptor
E0718_RS00525	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E0718_RS00535	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E0718_RS00555	COG0492	ferredoxin-NADP+ reductase activity
E0718_RS00560	COG0583	DNA-binding transcription factor activity
E0718_RS00590	COG2969	positive regulation of protein catabolic process
E0718_RS00595	COG0625	glutathione transferase activity
E0718_RS00600	COG2857	Cytochrome c1
E0718_RS00605	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
E0718_RS00610	COG0723	plastoquinol--plastocyanin reductase activity
E0718_RS00620	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
E0718_RS00645	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E0718_RS00650	COG0537	adenosine 5'-monophosphoramidase activity
E0718_RS00655	COG0140	phosphoribosyl-ATP diphosphatase activity
E0718_RS00670	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
E0718_RS00680	COG0131	Imidazoleglycerol-phosphate dehydratase
E0718_RS00690	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
E0718_RS00710	COG0842	Transport permease protein
E0718_RS00715	COG1131	(ABC) transporter
E0718_RS00725	COG2853	Lipoprotein
E0718_RS00730	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
E0718_RS00735	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
E0718_RS00740	COG1127	ABC transporter
E0718_RS00750	COG3047	cAMP biosynthetic process
E0718_RS00760	COG0069	glutamate synthase activity
E0718_RS00760	COG0067	glutamate synthase
E0718_RS00760	COG0070	glutamate synthase
E0718_RS00770	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
E0718_RS00775	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
E0718_RS00785	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E0718_RS00795	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
E0718_RS00815	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E0718_RS00860	COG1999	signal sequence binding
E0718_RS00885	COG2814	Major facilitator Superfamily
E0718_RS00900	COG2207	Transcriptional regulator
E0718_RS00900	COG3708	Transcriptional regulator
E0718_RS00935	COG1960	acyl-CoA dehydrogenase activity
E0718_RS00950	COG0183	Belongs to the thiolase family
E0718_RS00955	COG1522	sequence-specific DNA binding
E0718_RS00965	COG0583	DNA-binding transcription factor activity
E0718_RS00970	COG3181	Tripartite tricarboxylate transporter family receptor
E0718_RS00990	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E0718_RS01010	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E0718_RS01020	COG1802	Transcriptional regulator
E0718_RS01025	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
E0718_RS01035	COG1234	tRNA 3'-trailer cleavage
E0718_RS01045	COG0583	DNA-binding transcription factor activity
E0718_RS01050	COG3064	Membrane
E0718_RS01080	COG1683	Conserved Protein
E0718_RS01090	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E0718_RS01095	COG4558	Periplasmic binding protein
E0718_RS01100	COG3720	iron ion transport
E0718_RS01125	COG1595	DNA-templated transcription, initiation
E0718_RS01155	COG1802	Transcriptional regulator
E0718_RS01210	COG1607	acyl-coa hydrolase
E0718_RS01220	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E0718_RS01240	COG1028	Short-chain dehydrogenase reductase Sdr
E0718_RS01260	COG0512	Glutamine amidotransferase of anthranilate synthase
E0718_RS01270	COG0546	phosphoglycolate phosphatase activity
E0718_RS01275	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E0718_RS01280	COG2967	ApaG domain
E0718_RS01285	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
E0718_RS01290	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E0718_RS01300	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E0718_RS01325	COG1024	Enoyl-CoA hydratase
E0718_RS01340	COG0356	it plays a direct role in the translocation of protons across the membrane
E0718_RS01355	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
E0718_RS01375	COG0355	proton-transporting ATP synthase activity, rotational mechanism
E0718_RS01390	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E0718_RS01395	COG0210	DNA helicase
E0718_RS01400	COG2195	Cleaves the N-terminal amino acid of tripeptides
E0718_RS01410	COG4608	Belongs to the ABC transporter superfamily
E0718_RS01415	COG0444	Belongs to the ABC transporter superfamily
E0718_RS01420	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E0718_RS01425	COG0601	transmembrane transport
E0718_RS01435	COG0747	negative chemotaxis
E0718_RS01445	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E0718_RS01450	COG1024	Enoyl-CoA hydratase
E0718_RS01455	COG1024	Enoyl-CoA hydratase
E0718_RS01500	COG2132	Multicopper oxidase
E0718_RS01510	COG1250	3-hydroxyacyl-CoA dehydrogenase
E0718_RS01510	COG1024	Enoyl-CoA hydratase
E0718_RS01520	COG1414	Transcriptional regulator
E0718_RS01530	COG0154	amidase activity
E0718_RS01565	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E0718_RS01570	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
E0718_RS01575	COG0583	DNA-binding transcription factor activity
E0718_RS01620	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
E0718_RS01630	COG2813	Specifically methylates the guanine in position
E0718_RS01630	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E0718_RS01635	COG2223	nitrite transmembrane transporter activity
E0718_RS01640	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E0718_RS01645	COG1794	racemase activity, acting on amino acids and derivatives
E0718_RS01650	COG1126	abc transporter atp-binding protein
E0718_RS01655	COG0765	amino acid transport
E0718_RS01660	COG0765	amino acid transport
E0718_RS01665	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E0718_RS01670	COG2515	1-aminocyclopropane-1-carboxylate deaminase
E0718_RS01675	COG0583	DNA-binding transcription factor activity
E0718_RS01700	COG0473	3-isopropylmalate dehydrogenase activity
E0718_RS01705	COG0583	DNA-binding transcription factor activity
E0718_RS01715	COG2860	membrane
E0718_RS01725	COG0708	Exodeoxyribonuclease III
E0718_RS01750	COG1077	Cell shape determining protein MreB Mrl
E0718_RS01755	COG1792	Involved in formation and maintenance of cell shape
E0718_RS01765	COG0768	penicillin binding
E0718_RS01770	COG0772	Belongs to the SEDS family
E0718_RS01775	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
E0718_RS01780	COG0471	metal ion transport
E0718_RS01810	COG2823	Periplasmic or secreted lipoprotein
E0718_RS01815	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
E0718_RS01830	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E0718_RS01840	COG1660	Displays ATPase and GTPase activities
E0718_RS01850	COG2010	Cytochrome c
E0718_RS01850	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E0718_RS01865	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
E0718_RS01870	COG1137	ATPase activity
E0718_RS01885	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
E0718_RS01910	COG1294	oxidase, subunit
E0718_RS01920	COG4988	ABC transporter
E0718_RS01925	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
E0718_RS01945	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E0718_RS01950	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E0718_RS01955	COG1238	metal cluster binding
E0718_RS01965	COG1802	Transcriptional regulator
E0718_RS01980	COG1024	Enoyl-CoA hydratase
E0718_RS01990	COG3181	Tripartite tricarboxylate transporter family receptor
E0718_RS02005	COG1984	allophanate hydrolase subunit 2
E0718_RS02010	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
E0718_RS02020	COG0583	DNA-binding transcription factor activity
E0718_RS02025	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E0718_RS02035	COG5002	protein histidine kinase activity
E0718_RS02045	COG5002	protein histidine kinase activity
E0718_RS02050	COG0745	RESPONSE REGULATOR receiver
E0718_RS02055	COG2226	methyltransferase
E0718_RS02070	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
E0718_RS02080	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
E0718_RS02090	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
E0718_RS02095	COG0351	phosphomethylpyrimidine kinase
E0718_RS02105	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E0718_RS02110	COG4206	TonB-dependent receptor
E0718_RS02130	COG1194	a g-specific adenine glycosylase
E0718_RS02145	COG2177	Part of the ABC transporter FtsEX involved in
E0718_RS02150	COG2884	Cell division ATP-binding protein ftsE
E0718_RS02155	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E0718_RS02160	COG4597	amino acid ABC transporter
E0718_RS02165	COG0765	amino acid transport
E0718_RS02170	COG1126	abc transporter atp-binding protein
E0718_RS02200	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
E0718_RS02205	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
E0718_RS02230	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
E0718_RS02255	COG0494	nUDIX hydrolase
E0718_RS02315	COG1028	Short-chain dehydrogenase reductase Sdr
E0718_RS02325	COG1960	acyl-CoA dehydrogenase activity
E0718_RS02355	COG0352	thiamine-phosphate diphosphorylase activity
E0718_RS02370	COG1678	Uncharacterized ACR, COG1678
E0718_RS02405	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E0718_RS02420	COG0557	exoribonuclease II activity
E0718_RS02425	COG3150	esterase
E0718_RS02430	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E0718_RS02435	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E0718_RS02440	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
E0718_RS02445	COG0511	ligase activity, forming carbon-carbon bonds
E0718_RS02450	COG0439	Biotin carboxylase
E0718_RS02465	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E0718_RS02485	COG1696	Membrane protein involved in D-alanine export
E0718_RS02490	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E0718_RS02520	COG1522	sequence-specific DNA binding
E0718_RS02540	COG1042	CoA-binding domain protein
E0718_RS02540	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E0718_RS02540	COG0045	succinate-CoA ligase (ADP-forming) activity
E0718_RS02545	COG1802	Transcriptional regulator
E0718_RS02555	COG0513	Belongs to the DEAD box helicase family
E0718_RS02560	COG0346	lactoylglutathione lyase activity
E0718_RS02565	COG1335	isochorismatase
E0718_RS02570	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E0718_RS02575	COG1116	anion transmembrane transporter activity
E0718_RS02595	COG0312	modulator of DNA gyrase
E0718_RS02600	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
E0718_RS02605	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
E0718_RS02625	COG0316	Belongs to the HesB IscA family
E0718_RS02655	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
E0718_RS02660	COG4977	sequence-specific DNA binding
E0718_RS02670	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E0718_RS02670	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E0718_RS02675	COG2766	serine protein kinase
E0718_RS02680	COG2718	Belongs to the UPF0229 family
E0718_RS02685	COG2719	SpoVR family
E0718_RS02705	COG3799	methylaspartate ammonia-lyase activity
E0718_RS02710	COG2188	Transcriptional regulator
E0718_RS02725	COG0633	Ferredoxin
E0718_RS02740	COG0829	nickel cation binding
E0718_RS02745	COG0831	urea catabolic process
E0718_RS02755	COG0832	Belongs to the urease beta subunit family
E0718_RS02775	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
E0718_RS02800	COG3119	arylsulfatase activity
E0718_RS02815	COG3181	Tripartite tricarboxylate transporter family receptor
E0718_RS02835	COG2979	Protein of unknown function (DUF533)
E0718_RS02850	COG0741	lytic transglycosylase activity
E0718_RS02850	COG1388	LysM domain
E0718_RS02855	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E0718_RS02860	COG2226	methyltransferase
E0718_RS02865	COG0328	RNA-DNA hybrid ribonuclease activity
E0718_RS02875	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E0718_RS02880	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E0718_RS02895	COG2031	fatty acid transporter
E0718_RS02905	COG0786	glutamate:sodium symporter activity
E0718_RS02915	COG0463	Glycosyl transferase, family 2
E0718_RS02940	COG1073	alpha beta
E0718_RS02950	COG0697	spore germination
E0718_RS02955	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E0718_RS02980	COG1285	pathogenesis
E0718_RS02985	COG1253	flavin adenine dinucleotide binding
E0718_RS02990	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E0718_RS02995	COG1024	Enoyl-CoA hydratase
E0718_RS03000	COG3181	Tripartite tricarboxylate transporter family receptor
E0718_RS03005	COG0583	DNA-binding transcription factor activity
E0718_RS03010	COG1960	acyl-CoA dehydrogenase activity
E0718_RS03020	COG0183	Belongs to the thiolase family
E0718_RS03045	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E0718_RS03060	COG3181	Tripartite tricarboxylate transporter family receptor
E0718_RS03065	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
E0718_RS03070	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E0718_RS03095	COG0848	biopolymer transport protein
E0718_RS03100	COG0811	peptide transport
E0718_RS03105	COG0824	Thioesterase
E0718_RS03150	COG2084	Dehydrogenase
E0718_RS03205	COG4654	Cytochrome c, class I
E0718_RS03210	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E0718_RS03260	COG1473	amidohydrolase
E0718_RS03265	COG0418	dihydroorotase activity
E0718_RS03270	COG0488	(ABC) transporter
E0718_RS03280	COG2001	Belongs to the MraZ family
E0718_RS03285	COG0275	rRNA processing
E0718_RS03290	COG3116	cell division
E0718_RS03300	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E0718_RS03305	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E0718_RS03330	COG1181	Belongs to the D-alanine--D-alanine ligase family
E0718_RS03335	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
E0718_RS03345	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E0718_RS03350	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
E0718_RS03360	COG0739	heme binding
E0718_RS03385	COG1028	Short-chain dehydrogenase reductase Sdr
E0718_RS03390	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E0718_RS03395	COG1522	sequence-specific DNA binding
E0718_RS03410	COG2239	Acts as a magnesium transporter
E0718_RS03420	COG2855	membrane
E0718_RS03430	COG1473	amidohydrolase
E0718_RS03435	COG0318	PFAM AMP-dependent synthetase and ligase
E0718_RS03450	COG1501	Belongs to the glycosyl hydrolase 31 family
E0718_RS03455	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E0718_RS03460	COG2011	ABC-type metal ion transport system permease component
E0718_RS03475	COG1454	alcohol dehydrogenase
E0718_RS03495	COG2186	Transcriptional regulator
E0718_RS03515	COG1175	transmembrane transport
E0718_RS03520	COG0395	ABC-type sugar transport system, permease component
E0718_RS03525	COG3842	ATPase activity
E0718_RS03530	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E0718_RS03535	COG1653	transport
E0718_RS03555	COG2818	Glycosylase
E0718_RS03560	COG2982	Protein involved in outer membrane biogenesis
E0718_RS03565	COG1309	transcriptional regulator
E0718_RS03570	COG1028	Short-chain dehydrogenase reductase Sdr
E0718_RS03600	COG0179	Fumarylacetoacetate (FAA) hydrolase
E0718_RS03605	COG3384	dioxygenase
E0718_RS03625	COG0583	DNA-binding transcription factor activity
E0718_RS03640	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E0718_RS03645	COG2353	YceI-like domain
E0718_RS03650	COG4774	siderophore transport
E0718_RS03655	COG3712	iron ion homeostasis
E0718_RS03670	COG0019	diaminopimelate decarboxylase activity
E0718_RS03685	COG0747	negative chemotaxis
E0718_RS03695	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E0718_RS03705	COG0154	amidase activity
E0718_RS03710	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E0718_RS03730	COG2154	pterin-4-alpha-carbinolamine dehydratase
E0718_RS03740	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
E0718_RS03770	COG0469	pyruvate kinase activity
E0718_RS03775	COG0700	Nucleoside recognition
E0718_RS03780	COG1960	acyl-CoA dehydrogenase activity
E0718_RS03785	COG0242	peptide deformylase activity
E0718_RS03800	COG0204	Acyl-transferase
E0718_RS03805	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
E0718_RS03810	COG0751	glycine-tRNA ligase activity
E0718_RS03815	COG0752	glycyl-tRNA synthetase alpha subunit
E0718_RS03830	COG0066	3-isopropylmalate dehydratase activity
E0718_RS03835	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
E0718_RS03840	COG2188	Transcriptional regulator
E0718_RS03850	COG1024	Enoyl-CoA hydratase
E0718_RS03860	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
E0718_RS03865	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E0718_RS03870	COG2301	Belongs to the HpcH HpaI aldolase family
E0718_RS03875	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E0718_RS03880	COG3181	Tripartite tricarboxylate transporter family receptor
E0718_RS03885	COG1028	Short-chain dehydrogenase reductase Sdr
E0718_RS03895	COG1028	Short-chain dehydrogenase reductase Sdr
E0718_RS03900	COG1234	tRNA 3'-trailer cleavage
E0718_RS03905	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E0718_RS03915	COG2188	Transcriptional regulator
E0718_RS03920	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
E0718_RS03945	COG0617	tRNA 3'-terminal CCA addition
E0718_RS03975	COG0586	Pfam SNARE associated Golgi protein
E0718_RS03980	COG0860	N-Acetylmuramoyl-L-alanine amidase
E0718_RS03985	COG0802	atpase or kinase
E0718_RS04000	COG3181	Tripartite tricarboxylate transporter family receptor
E0718_RS04010	COG0405	Gamma-glutamyltransferase
E0718_RS04015	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E0718_RS04025	COG1960	acyl-CoA dehydrogenase activity
E0718_RS04030	COG0583	DNA-binding transcription factor activity
E0718_RS04045	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E0718_RS04050	COG0259	pyridoxamine-phosphate oxidase activity
E0718_RS04060	COG2814	Major facilitator Superfamily
E0718_RS04065	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
E0718_RS04070	COG2188	Transcriptional regulator
E0718_RS04075	COG0318	PFAM AMP-dependent synthetase and ligase
E0718_RS04090	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E0718_RS04100	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E0718_RS04110	COG1215	transferase activity, transferring glycosyl groups
E0718_RS04120	COG0601	transmembrane transport
E0718_RS04125	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E0718_RS04130	COG0444	Belongs to the ABC transporter superfamily
E0718_RS04135	COG4608	Belongs to the ABC transporter superfamily
E0718_RS04160	COG0488	(ABC) transporter
E0718_RS04175	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
E0718_RS04180	COG2894	cell division
E0718_RS04195	COG1271	oxidase subunit
E0718_RS04220	COG0514	ATP-dependent DNA helicase (RecQ)
E0718_RS04265	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E0718_RS04275	COG0006	proline dipeptidase activity
E0718_RS04290	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E0718_RS04305	COG4783	chaperone-mediated protein folding
E0718_RS04310	COG0429	hydrolase of the alpha beta-hydrolase fold
E0718_RS04340	COG0513	Belongs to the DEAD box helicase family
E0718_RS04355	COG1058	Belongs to the CinA family
E0718_RS04355	COG1546	Belongs to the CinA family
E0718_RS04360	COG1414	Transcriptional regulator
E0718_RS04400	COG0583	DNA-binding transcription factor activity
E0718_RS04430	COG1280	lysine exporter protein (LysE YggA)
E0718_RS04445	COG0405	Gamma-glutamyltransferase
E0718_RS04455	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E0718_RS04470	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E0718_RS04485	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
E0718_RS04485	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E0718_RS04495	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E0718_RS04520	COG1024	Enoyl-CoA hydratase
E0718_RS04530	COG2030	dehydratase
E0718_RS04535	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E0718_RS04555	COG0583	DNA-binding transcription factor activity
E0718_RS04565	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E0718_RS04570	COG4311	Sarcosine oxidase, delta subunit
E0718_RS04575	COG0446	pyridine nucleotide-disulphide oxidoreductase
E0718_RS04575	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E0718_RS04620	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E0718_RS04625	COG0735	belongs to the Fur family
E0718_RS04635	COG0497	DNA recombination
E0718_RS04645	COG1420	regulation of RNA biosynthetic process
E0718_RS04660	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
E0718_RS04680	COG0612	Peptidase, M16
E0718_RS04700	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E0718_RS04735	COG0745	RESPONSE REGULATOR receiver
E0718_RS04740	COG2205	protein histidine kinase activity
E0718_RS04745	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
E0718_RS04750	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
E0718_RS04770	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E0718_RS04780	COG1193	negative regulation of DNA recombination
E0718_RS04785	COG0492	ferredoxin-NADP+ reductase activity
E0718_RS04790	COG1674	ftsk spoiiie
E0718_RS04800	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E0718_RS04835	COG3706	GGDEF domain
E0718_RS04855	COG2814	Major facilitator Superfamily
E0718_RS04885	COG3486	L-lysine 6-monooxygenase (NADPH) activity
E0718_RS04900	COG1028	Short-chain dehydrogenase reductase Sdr
E0718_RS04905	COG3022	response to hydroperoxide
E0718_RS04915	COG1289	transmembrane transporter activity
E0718_RS04920	COG0028	Belongs to the TPP enzyme family
E0718_RS04925	COG0440	acetolactate synthase activity
E0718_RS04935	COG1183	phosphatidylcholine synthase activity
E0718_RS04945	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
E0718_RS04950	COG1185	polyribonucleotide nucleotidyltransferase activity
E0718_RS04960	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E0718_RS04980	COG0149	triose-phosphate isomerase activity
E0718_RS04985	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E0718_RS04995	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E0718_RS05005	COG3799	methylaspartate ammonia-lyase activity
E0718_RS05020	COG0165	Argininosuccinate lyase
E0718_RS05025	COG3181	Tripartite tricarboxylate transporter family receptor
E0718_RS05035	COG0583	DNA-binding transcription factor activity
E0718_RS05040	COG0626	cystathionine gamma-synthase activity
E0718_RS05045	COG3608	succinylglutamate desuccinylase aspartoacylase
E0718_RS05065	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E0718_RS05085	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
E0718_RS05105	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E0718_RS05110	COG1733	regulation of RNA biosynthetic process
E0718_RS05115	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E0718_RS05120	COG0583	DNA-binding transcription factor activity
E0718_RS05125	COG1597	lipid kinase activity
E0718_RS05135	COG0671	phosphoesterase, PA-phosphatase related
E0718_RS05155	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E0718_RS05160	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E0718_RS05165	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E0718_RS05180	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
E0718_RS05190	COG1034	ATP synthesis coupled electron transport
E0718_RS05195	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
E0718_RS05200	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E0718_RS05210	COG0713	ATP synthesis coupled electron transport
E0718_RS05225	COG1007	ATP synthesis coupled electron transport
E0718_RS05235	COG4774	siderophore transport
E0718_RS05260	COG0028	Belongs to the TPP enzyme family
E0718_RS05265	COG3181	Tripartite tricarboxylate transporter family receptor
E0718_RS05270	COG0583	DNA-binding transcription factor activity
E0718_RS05275	COG0560	Phosphoserine phosphatase
E0718_RS05280	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
E0718_RS05290	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
E0718_RS05310	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E0718_RS05315	COG0450	alkyl hydroperoxide reductase
E0718_RS05330	COG1214	PFAM Peptidase M22, glycoprotease
E0718_RS05335	COG1573	uracil-dna glycosylase
E0718_RS05340	COG0477	Major facilitator Superfamily
E0718_RS05345	COG1196	nuclear chromosome segregation
E0718_RS05360	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E0718_RS05365	COG0271	Belongs to the BolA IbaG family
E0718_RS05375	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E0718_RS05380	COG1122	ATPase activity
E0718_RS05385	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
E0718_RS05390	COG1268	BioY protein
E0718_RS05415	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E0718_RS05450	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E0718_RS05455	COG2878	Part of a membrane complex involved in electron transport
E0718_RS05470	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
E0718_RS05480	COG0251	oxidation-reduction process
E0718_RS05490	COG3228	Belongs to the MtfA family
E0718_RS05515	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
E0718_RS05520	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
E0718_RS05530	COG1530	ribonuclease E activity
E0718_RS05540	COG0546	phosphoglycolate phosphatase activity
E0718_RS05545	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
E0718_RS05555	COG3023	N-Acetylmuramoyl-L-alanine amidase
E0718_RS05570	COG1399	metal-binding, possibly nucleic acid-binding protein
E0718_RS05575	COG0333	Belongs to the bacterial ribosomal protein bL32 family
E0718_RS05600	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E0718_RS05605	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E0718_RS05630	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E0718_RS05640	COG0681	Belongs to the peptidase S26 family
E0718_RS05645	COG0571	ribonuclease III activity
E0718_RS05650	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
E0718_RS05655	COG1381	Involved in DNA repair and RecF pathway recombination
E0718_RS05665	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E0718_RS05675	COG3181	Tripartite tricarboxylate transporter family receptor
E0718_RS05680	COG0670	Belongs to the BI1 family
E0718_RS05705	COG0583	DNA-binding transcription factor activity
E0718_RS05720	COG0583	DNA-binding transcription factor activity
E0718_RS05730	COG0791	NLP P60 protein
E0718_RS05735	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E0718_RS05740	COG3193	protein, possibly involved in utilization of glycolate and propanediol
E0718_RS05750	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E0718_RS05755	COG0697	spore germination
E0718_RS05760	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
E0718_RS05775	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E0718_RS05805	COG1446	asparaginase
E0718_RS05810	COG4172	Belongs to the ABC transporter superfamily
E0718_RS05815	COG0747	negative chemotaxis
E0718_RS05825	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E0718_RS05845	COG0504	CTP synthase activity
E0718_RS05850	COG2877	3-deoxy-8-phosphooctulonate synthase activity
E0718_RS05860	COG0148	phosphopyruvate hydratase activity
E0718_RS05895	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
E0718_RS05905	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E0718_RS05930	COG1981	membrane
E0718_RS05940	COG2828	Protein conserved in bacteria
E0718_RS05960	COG0039	L-malate dehydrogenase activity
E0718_RS05965	COG2188	Transcriptional regulator
E0718_RS05970	COG2009	succinate dehydrogenase
E0718_RS05975	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
E0718_RS05980	COG1053	succinate dehydrogenase
E0718_RS05985	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E0718_RS05990	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
E0718_RS05995	COG0372	Belongs to the citrate synthase family
E0718_RS06010	COG3539	Fimbrial protein
E0718_RS06015	COG0281	malic enzyme
E0718_RS06015	COG0280	phosphate acetyltransferase
E0718_RS06025	COG1522	sequence-specific DNA binding
E0718_RS06035	COG0567	Dehydrogenase, E1 component
E0718_RS06040	COG0508	dehydrogenase complex catalyzes the overall conversion of
E0718_RS06045	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E0718_RS06050	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
E0718_RS06055	COG1028	Short-chain dehydrogenase reductase Sdr
E0718_RS06060	COG0583	DNA-binding transcription factor activity
E0718_RS06065	COG3181	Tripartite tricarboxylate transporter family receptor
E0718_RS06075	COG2175	clavaminate synthase activity
E0718_RS06080	COG1595	DNA-templated transcription, initiation
E0718_RS06090	COG3712	iron ion homeostasis
E0718_RS06095	COG4774	siderophore transport
E0718_RS06120	COG2183	response to ionizing radiation
E0718_RS06125	COG1199	ATP-dependent helicase activity
E0718_RS06135	COG0564	pseudouridine synthase activity
E0718_RS06145	COG3243	poly(R)-hydroxyalkanoic acid synthase
E0718_RS06150	COG1028	Short-chain dehydrogenase reductase Sdr
E0718_RS06155	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
E0718_RS06170	COG0672	)-iron permease
E0718_RS06190	COG2823	Periplasmic or secreted lipoprotein
E0718_RS06200	COG3237	CsbD-like
E0718_RS06205	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E0718_RS06205	COG1181	Belongs to the D-alanine--D-alanine ligase family
E0718_RS06215	COG1132	(ABC) transporter
E0718_RS06230	COG2833	Protein of unknown function (DUF455)
E0718_RS06235	COG2951	lytic endotransglycosylase activity
E0718_RS06245	COG0589	response to stress
E0718_RS06250	COG3706	GGDEF domain
E0718_RS06255	COG2814	Major facilitator Superfamily
E0718_RS06260	COG0778	Nitroreductase
E0718_RS06280	COG0436	Aminotransferase
E0718_RS06285	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
E0718_RS06285	COG0028	Belongs to the TPP enzyme family
E0718_RS06315	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E0718_RS06325	COG2079	MmgE PrpD family protein
E0718_RS06330	COG1012	belongs to the aldehyde dehydrogenase family
E0718_RS06335	COG1053	succinate dehydrogenase
E0718_RS06360	COG0179	Fumarylacetoacetate (FAA) hydrolase
E0718_RS06375	COG0583	DNA-binding transcription factor activity
E0718_RS06425	COG0583	DNA-binding transcription factor activity
E0718_RS06450	COG2814	Major facilitator Superfamily
E0718_RS06485	COG0287	Prephenate dehydrogenase
E0718_RS06515	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
E0718_RS06520	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
E0718_RS06545	COG2951	lytic endotransglycosylase activity
E0718_RS06550	COG0123	including yeast histone deacetylase and acetoin utilization protein
E0718_RS06565	COG1960	acyl-CoA dehydrogenase activity
E0718_RS06570	COG0450	alkyl hydroperoxide reductase
E0718_RS06600	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E0718_RS06630	COG1053	succinate dehydrogenase
E0718_RS06630	COG3976	FMN-binding domain protein
E0718_RS06635	COG3181	Tripartite tricarboxylate transporter family receptor
E0718_RS06665	COG3842	ATPase activity
E0718_RS06675	COG0395	ABC-type sugar transport system, permease component
E0718_RS06710	COG0420	3'-5' exonuclease activity
E0718_RS06725	COG2111	Na H antiporter
E0718_RS06725	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E0718_RS06730	COG1006	Multisubunit Na H antiporter MnhC subunit
E0718_RS06735	COG0651	ATP synthesis coupled electron transport
E0718_RS06740	COG1863	multisubunit Na H antiporter MnhE subunit
E0718_RS06745	COG2212	antiporter activity
E0718_RS06765	COG0590	tRNA wobble adenosine to inosine editing
E0718_RS06770	COG1619	proteins homologs of microcin C7 resistance protein MccF
E0718_RS06775	COG1024	Enoyl-CoA hydratase
E0718_RS06780	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E0718_RS06790	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
E0718_RS06795	COG0488	(ABC) transporter
E0718_RS06825	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E0718_RS06830	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E0718_RS06835	COG2252	PERMEase
E0718_RS06845	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
E0718_RS06885	COG0789	Transcriptional regulator
E0718_RS06895	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
E0718_RS06895	COG0678	peroxiredoxin activity
E0718_RS06905	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
E0718_RS06910	COG0584	glycerophosphoryl diester phosphodiesterase
E0718_RS06915	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E0718_RS06925	COG4181	ATPase activity
E0718_RS06965	COG4336	lyase activity
E0718_RS06980	COG2197	response regulator
E0718_RS06990	COG3210	domain, Protein
E0718_RS06990	COG3064	Membrane
E0718_RS06990	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
E0718_RS07000	COG3121	Chaperone
E0718_RS07005	COG3188	usher protein
E0718_RS07010	COG3539	Fimbrial protein
E0718_RS07015	COG2831	hemolysin activation secretion protein
E0718_RS07030	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E0718_RS07055	COG0583	DNA-binding transcription factor activity
E0718_RS07075	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E0718_RS07080	COG0765	amino acid transport
E0718_RS07085	COG1126	abc transporter atp-binding protein
E0718_RS07090	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E0718_RS07095	COG1758	RNA polymerase activity
E0718_RS07100	COG0194	GDP metabolic process
E0718_RS07105	COG3258	Cytochrome c
E0718_RS07110	COG2863	cytochrome
E0718_RS07115	COG1028	Short-chain dehydrogenase reductase Sdr
E0718_RS07120	COG0791	NLP P60 protein
E0718_RS07125	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E0718_RS07170	COG5001	Diguanylate cyclase
E0718_RS07170	COG5002	protein histidine kinase activity
E0718_RS07180	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E0718_RS07185	COG0174	glutamine synthetase
E0718_RS07195	COG2204	response regulator
E0718_RS07200	COG0583	DNA-binding transcription factor activity
E0718_RS07205	COG1741	Belongs to the pirin family
E0718_RS07210	COG1741	Belongs to the pirin family
E0718_RS07215	COG3842	ATPase activity
E0718_RS07225	COG1840	ABC-type Fe3 transport system, periplasmic component
E0718_RS07235	COG0583	DNA-binding transcription factor activity
E0718_RS07240	COG2814	Major facilitator Superfamily
E0718_RS07245	COG0656	L-ascorbic acid biosynthetic process
E0718_RS07260	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E0718_RS07265	COG0583	DNA-binding transcription factor activity
E0718_RS07280	COG0783	Belongs to the Dps family
E0718_RS07300	COG0463	Glycosyl transferase, family 2
E0718_RS07320	COG0438	transferase activity, transferring glycosyl groups
E0718_RS07335	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
E0718_RS07355	COG0300	oxidoreductase activity
E0718_RS07365	COG0156	8-amino-7-oxononanoate synthase activity
E0718_RS07370	COG3321	synthase
E0718_RS07370	COG1028	Short-chain dehydrogenase reductase Sdr
E0718_RS07370	COG0604	alcohol dehydrogenase
E0718_RS07390	COG0395	ABC-type sugar transport system, permease component
E0718_RS07395	COG1175	transmembrane transport
E0718_RS07400	COG1653	transport
E0718_RS07410	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
E0718_RS07420	COG0559	Belongs to the binding-protein-dependent transport system permease family
E0718_RS07440	COG1794	racemase activity, acting on amino acids and derivatives
E0718_RS07445	COG0625	glutathione transferase activity
E0718_RS07450	COG2133	pyrroloquinoline quinone binding
E0718_RS07475	COG2363	Small membrane protein
E0718_RS07490	COG1464	Belongs to the NlpA lipoprotein family
E0718_RS07500	COG0688	phosphatidylethanolamine metabolic process
E0718_RS07515	COG0095	Lipoate-protein ligase
E0718_RS07530	COG0625	glutathione transferase activity
E0718_RS07535	COG0386	Belongs to the glutathione peroxidase family
E0718_RS07575	COG2259	Doxx family
E0718_RS07590	COG0667	Aldo Keto reductase
E0718_RS07635	COG1640	4-alpha-glucanotransferase
E0718_RS07645	COG1523	belongs to the glycosyl hydrolase 13 family
E0718_RS07675	COG0366	Alpha amylase catalytic
E0718_RS07690	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
E0718_RS07715	COG0747	negative chemotaxis
E0718_RS07720	COG0601	transmembrane transport
E0718_RS07725	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E0718_RS07730	COG4172	Belongs to the ABC transporter superfamily
E0718_RS07785	COG0425	Belongs to the sulfur carrier protein TusA family
E0718_RS07810	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E0718_RS07820	COG0642	Histidine kinase
E0718_RS07840	COG0105	UTP biosynthetic process
E0718_RS07865	COG2976	Protein conserved in bacteria
E0718_RS07870	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E0718_RS07875	COG1160	GTP binding
E0718_RS07885	COG1923	regulation of RNA biosynthetic process
E0718_RS07890	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E0718_RS07895	COG0330	HflC and HflK could
E0718_RS07900	COG0330	HflC and HflK could
E0718_RS07915	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
E0718_RS07920	COG0828	Belongs to the bacterial ribosomal protein bS21 family
E0718_RS07930	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E0718_RS07990	COG0559	Belongs to the binding-protein-dependent transport system permease family
E0718_RS07995	COG0683	leucine binding
E0718_RS08000	COG4638	Rieske (2fe-2S)
E0718_RS08010	COG1024	Enoyl-CoA hydratase
E0718_RS08020	COG0633	Ferredoxin
E0718_RS08025	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E0718_RS08045	COG0183	Belongs to the thiolase family
E0718_RS08055	COG4692	amylo-alpha-1,6-glucosidase activity
E0718_RS08060	COG0583	DNA-binding transcription factor activity
E0718_RS08075	COG0028	Belongs to the TPP enzyme family
E0718_RS08080	COG1012	belongs to the aldehyde dehydrogenase family
E0718_RS08085	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E0718_RS08100	COG4943	cyclic-guanylate-specific phosphodiesterase activity
E0718_RS08110	COG3829	transcription factor binding
E0718_RS08140	COG0833	amino acid
E0718_RS08160	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E0718_RS08165	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
E0718_RS08170	COG0439	Biotin carboxylase
E0718_RS08195	COG0395	ABC-type sugar transport system, permease component
E0718_RS08200	COG1176	ABC-type spermidine putrescine transport system, permease component I
E0718_RS08210	COG3842	ATPase activity
E0718_RS08220	COG1414	Transcriptional regulator
E0718_RS08225	COG1028	Short-chain dehydrogenase reductase Sdr
E0718_RS08235	COG2188	Transcriptional regulator
E0718_RS08260	COG3181	Tripartite tricarboxylate transporter family receptor
E0718_RS08265	COG0583	DNA-binding transcription factor activity
E0718_RS08285	COG1172	Belongs to the binding-protein-dependent transport system permease family
E0718_RS08295	COG0179	Fumarylacetoacetate (FAA) hydrolase
E0718_RS08305	COG1228	amidohydrolase
E0718_RS08310	COG2267	carboxylic ester hydrolase activity
E0718_RS08335	COG0861	Integral membrane protein TerC family
E0718_RS08340	COG1028	Short-chain dehydrogenase reductase Sdr
E0718_RS08355	COG1262	PFAM Formylglycine-generating sulfatase enzyme
E0718_RS08400	COG3119	arylsulfatase activity
E0718_RS08420	COG2197	response regulator
E0718_RS08430	COG2944	sequence-specific DNA binding
E0718_RS08435	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
E0718_RS08440	COG0625	glutathione transferase activity
E0718_RS08455	COG3119	arylsulfatase activity
E0718_RS08470	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E0718_RS08475	COG0183	Belongs to the thiolase family
E0718_RS08490	COG1028	Short-chain dehydrogenase reductase Sdr
E0718_RS08495	COG0583	DNA-binding transcription factor activity
E0718_RS08500	COG3181	Tripartite tricarboxylate transporter family receptor
E0718_RS08510	COG1024	Enoyl-CoA hydratase
E0718_RS08520	COG3181	Tripartite tricarboxylate transporter family receptor
E0718_RS08525	COG1024	Enoyl-CoA hydratase
E0718_RS08525	COG1250	3-hydroxyacyl-CoA dehydrogenase
E0718_RS08535	COG1454	alcohol dehydrogenase
E0718_RS08540	COG0824	Thioesterase
E0718_RS08565	COG0431	NADPH-dependent FMN reductase
E0718_RS08595	COG1028	Short-chain dehydrogenase reductase Sdr
E0718_RS08600	COG0583	DNA-binding transcription factor activity
E0718_RS08625	COG0330	HflC and HflK could
E0718_RS08645	COG3043	anaerobic respiration
E0718_RS08650	COG3005	denitrification pathway
E0718_RS08685	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E0718_RS08720	COG4948	Mandelate Racemase Muconate Lactonizing
E0718_RS08725	COG3181	Tripartite tricarboxylate transporter family receptor
E0718_RS08755	COG0583	DNA-binding transcription factor activity
E0718_RS08775	COG1695	Transcriptional regulator
E0718_RS08785	COG3568	Endonuclease Exonuclease Phosphatase
E0718_RS08795	COG0392	lysyltransferase activity
E0718_RS08830	COG4575	ribosome binding
E0718_RS08835	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
E0718_RS08845	COG1028	Short-chain dehydrogenase reductase Sdr
E0718_RS08900	COG0028	Belongs to the TPP enzyme family
E0718_RS08905	COG2204	response regulator
E0718_RS08910	COG2204	response regulator
E0718_RS08955	COG0861	Integral membrane protein TerC family
E0718_RS08960	COG0861	Integral membrane protein TerC family
E0718_RS08965	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
E0718_RS08970	COG0045	succinate-CoA ligase (ADP-forming) activity
E0718_RS08990	COG2137	regulation of response to DNA damage stimulus
E0718_RS08995	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
E0718_RS09015	COG1024	Enoyl-CoA hydratase
E0718_RS09015	COG1250	3-hydroxyacyl-CoA dehydrogenase
E0718_RS09020	COG3842	ATPase activity
E0718_RS09040	COG1028	Short-chain dehydrogenase reductase Sdr
E0718_RS09055	COG0183	Belongs to the thiolase family
E0718_RS09070	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E0718_RS09085	COG0540	Belongs to the ATCase OTCase family
E0718_RS09120	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E0718_RS09135	COG1522	sequence-specific DNA binding
E0718_RS09145	COG2367	Beta-lactamase
E0718_RS09160	COG0500	methyltransferase
E0718_RS09200	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
E0718_RS09205	COG0291	Belongs to the bacterial ribosomal protein bL35 family
E0718_RS09225	COG0004	ammonium transporteR
E0718_RS09240	COG1309	transcriptional regulator
E0718_RS09275	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E0718_RS09275	COG0506	proline dehydrogenase activity
E0718_RS09275	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E0718_RS09285	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
E0718_RS09285	COG3008	intermembrane lipid transfer
E0718_RS09290	COG2995	paraquat-inducible protein a
E0718_RS09295	COG0542	response to heat
E0718_RS09300	COG4953	penicillin-binding protein 1C
E0718_RS09315	COG1278	Cold shock
E0718_RS09325	COG0183	Belongs to the thiolase family
E0718_RS09330	COG0038	chloride channel
E0718_RS09335	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
E0718_RS09345	COG0811	peptide transport
E0718_RS09350	COG0848	biopolymer transport protein
E0718_RS09360	COG2835	tetraacyldisaccharide 4'-kinase activity
E0718_RS09380	COG0728	peptidoglycan biosynthetic process
E0718_RS09390	COG0268	Binds directly to 16S ribosomal RNA
E0718_RS09410	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
E0718_RS09415	COG2186	Transcriptional regulator
E0718_RS09435	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E0718_RS09445	COG0583	DNA-binding transcription factor activity
E0718_RS09460	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E0718_RS09470	COG3158	transport of potassium into the cell
E0718_RS09475	COG0642	Histidine kinase
E0718_RS09505	COG0776	regulation of translation
E0718_RS09510	COG3128	pkhd-type hydroxylase
E0718_RS09520	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E0718_RS09525	COG0557	exoribonuclease II activity
E0718_RS09550	COG0679	Auxin Efflux Carrier
E0718_RS09555	COG2391	methyltransferase activity
E0718_RS09560	COG0069	glutamate synthase activity
E0718_RS09565	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E0718_RS09575	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
E0718_RS09615	COG3706	GGDEF domain
E0718_RS09650	COG3909	cytochrome
E0718_RS09655	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E0718_RS09660	COG0625	glutathione transferase activity
E0718_RS09665	COG0730	response to heat
E0718_RS09675	COG0583	DNA-binding transcription factor activity
E0718_RS09715	COG2819	hydrolase of the alpha beta superfamily
E0718_RS09720	COG0247	lactate metabolic process
E0718_RS09730	COG0277	FAD linked oxidase domain protein
E0718_RS09735	COG0277	FAD linked oxidase domain protein
E0718_RS09740	COG3064	Membrane
E0718_RS09740	COG3210	domain, Protein
E0718_RS09740	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
E0718_RS09740	COG3064	Membrane
E0718_RS09740	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
E0718_RS09740	COG3210	domain, Protein
E0718_RS09745	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E0718_RS09750	COG0312	modulator of DNA gyrase
E0718_RS09770	COG0308	aminopeptidase N
E0718_RS09775	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
E0718_RS09795	COG0436	Aminotransferase
E0718_RS09800	COG3737	Protein of unknown function (DUF498/DUF598)
E0718_RS09805	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E0718_RS09810	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
E0718_RS09815	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
E0718_RS09825	COG0305	Participates in initiation and elongation during chromosome replication
E0718_RS09845	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
E0718_RS09850	COG2965	DNA replication, synthesis of RNA primer
E0718_RS09855	COG0360	Binds together with S18 to 16S ribosomal RNA
E0718_RS09860	COG1469	GTP cyclohydrolase I activity
E0718_RS09870	COG0142	geranyltranstransferase activity
E0718_RS09875	COG1722	exodeoxyribonuclease VII activity
E0718_RS09885	COG3181	Tripartite tricarboxylate transporter family receptor
E0718_RS09915	COG1840	ABC-type Fe3 transport system, periplasmic component
E0718_RS09920	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E0718_RS09925	COG1178	ABC-type Fe3 transport system permease component
E0718_RS09930	COG3842	ATPase activity
E0718_RS09935	COG0583	DNA-binding transcription factor activity
E0718_RS09955	COG0501	Belongs to the peptidase M48B family
E0718_RS09965	COG0697	spore germination
E0718_RS09975	COG1846	Transcriptional regulator
E0718_RS09995	COG0473	3-isopropylmalate dehydrogenase activity
E0718_RS10005	COG0747	negative chemotaxis
E0718_RS10015	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E0718_RS10025	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
E0718_RS10050	COG1012	belongs to the aldehyde dehydrogenase family
E0718_RS10060	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E0718_RS10065	COG0433	COG0433 Predicted ATPase
E0718_RS10075	COG0151	Belongs to the GarS family
E0718_RS10090	COG0799	negative regulation of ribosome biogenesis
E0718_RS10105	COG3468	outer membrane autotransporter barrel domain protein
E0718_RS10145	COG0385	Bile acid
E0718_RS10150	COG0427	acetyl-CoA hydrolase
E0718_RS10155	COG0583	DNA-binding transcription factor activity
E0718_RS10160	COG3264	Mechanosensitive ion channel
E0718_RS10160	COG1511	domain protein
E0718_RS10175	COG0730	response to heat
E0718_RS10180	COG0697	spore germination
E0718_RS10215	COG2885	chlorophyll binding
E0718_RS10235	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
E0718_RS10240	COG3384	dioxygenase
E0718_RS10255	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
E0718_RS10260	COG3474	cytochrome
E0718_RS10325	COG4964	Belongs to the GSP D family
E0718_RS10375	COG4172	Belongs to the ABC transporter superfamily
E0718_RS10380	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E0718_RS10385	COG0601	transmembrane transport
E0718_RS10390	COG0747	negative chemotaxis
E0718_RS10400	COG0598	Magnesium transport protein CorA
E0718_RS10420	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
E0718_RS10430	COG0483	inositol monophosphate 1-phosphatase activity
E0718_RS10460	COG1045	serine acetyltransferase
E0718_RS10465	COG0166	Belongs to the GPI family
E0718_RS10480	COG2197	response regulator
E0718_RS10495	COG0183	Belongs to the thiolase family
E0718_RS10510	COG1024	Enoyl-CoA hydratase
E0718_RS10510	COG1250	3-hydroxyacyl-CoA dehydrogenase
E0718_RS10515	COG0183	Belongs to the thiolase family
E0718_RS10525	COG0318	PFAM AMP-dependent synthetase and ligase
E0718_RS10535	COG3181	Tripartite tricarboxylate transporter family receptor
E0718_RS10550	COG1017	nitric oxide dioxygenase activity
E0718_RS10550	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E0718_RS10555	COG2010	Cytochrome c
E0718_RS10555	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E0718_RS10560	COG1335	isochorismatase
E0718_RS10565	COG2309	aminopeptidase activity
E0718_RS10570	COG0596	Alpha beta hydrolase
E0718_RS10575	COG3473	Maleate cis-trans isomerase
E0718_RS10580	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E0718_RS10585	COG2080	2 iron, 2 sulfur cluster binding
E0718_RS10615	COG1846	Transcriptional regulator
E0718_RS10635	COG0726	polysaccharide deacetylase
E0718_RS10635	COG1649	PFAM Uncharacterised BCR, COG1649
E0718_RS10640	COG1215	transferase activity, transferring glycosyl groups
E0718_RS10650	COG1902	pentaerythritol trinitrate reductase activity
E0718_RS10675	COG0251	oxidation-reduction process
E0718_RS10685	COG1832	CoA-binding protein
E0718_RS10690	COG1414	Transcriptional regulator
E0718_RS10695	COG0446	pyridine nucleotide-disulphide oxidoreductase
E0718_RS10695	COG1902	pentaerythritol trinitrate reductase activity
E0718_RS10705	COG3842	ATPase activity
E0718_RS10735	COG0583	DNA-binding transcription factor activity
E0718_RS10745	COG1028	Short-chain dehydrogenase reductase Sdr
E0718_RS10755	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E0718_RS10770	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
E0718_RS10770	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E0718_RS10795	COG0527	aspartate kinase activity
E0718_RS10805	COG0825	malonyl-CoA metabolic process
E0718_RS10820	COG3063	Type IV pilus biogenesis stability protein PilW
E0718_RS10840	COG1253	flavin adenine dinucleotide binding
E0718_RS10845	COG0483	inositol monophosphate 1-phosphatase activity
E0718_RS10865	COG0668	transmembrane transport
E0718_RS10900	COG3360	Dodecin
E0718_RS10910	COG2850	peptidyl-arginine hydroxylation
E0718_RS10920	COG3539	Fimbrial protein
E0718_RS10925	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
E0718_RS10930	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E0718_RS10935	COG1994	Peptidase M50
E0718_RS10940	COG0009	L-threonylcarbamoyladenylate synthase
E0718_RS10945	COG2321	neutral zinc metallopeptidase
E0718_RS10985	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E0718_RS10990	COG1366	Belongs to the anti-sigma-factor antagonist family
E0718_RS11000	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E0718_RS11010	COG2208	phosphoserine phosphatase activity
E0718_RS11010	COG2770	Histidine kinase
E0718_RS11045	COG4792	protein secretion
E0718_RS11050	COG4791	protein targeting
E0718_RS11055	COG4794	Type iii secretion
E0718_RS11060	COG4790	Type iii secretion
E0718_RS11095	COG4669	(LipO)protein
E0718_RS11195	COG0251	oxidation-reduction process
E0718_RS11235	COG1028	Short-chain dehydrogenase reductase Sdr
E0718_RS11285	COG0179	Fumarylacetoacetate (FAA) hydrolase
E0718_RS11300	COG0583	DNA-binding transcription factor activity
E0718_RS11305	COG3971	2-oxopent-4-enoate hydratase activity
E0718_RS11335	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E0718_RS11355	COG0511	ligase activity, forming carbon-carbon bonds
E0718_RS11365	COG0439	Biotin carboxylase
E0718_RS11370	COG2188	Transcriptional regulator
E0718_RS11395	COG0511	ligase activity, forming carbon-carbon bonds
E0718_RS11405	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
E0718_RS11415	COG1012	belongs to the aldehyde dehydrogenase family
E0718_RS11425	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
E0718_RS11450	COG1132	(ABC) transporter
E0718_RS11460	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E0718_RS11500	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E0718_RS11535	COG0583	DNA-binding transcription factor activity
E0718_RS11555	COG3181	Tripartite tricarboxylate transporter family receptor
E0718_RS11585	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E0718_RS11600	COG1126	abc transporter atp-binding protein
E0718_RS11605	COG0765	amino acid transport
E0718_RS11610	COG4597	amino acid ABC transporter
E0718_RS11615	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E0718_RS11620	COG1473	amidohydrolase
E0718_RS11625	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E0718_RS11630	COG1522	sequence-specific DNA binding
E0718_RS11640	COG0179	Fumarylacetoacetate (FAA) hydrolase
E0718_RS11650	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E0718_RS11655	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
E0718_RS11660	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E0718_RS11680	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E0718_RS11685	COG0154	amidase activity
E0718_RS11695	COG1137	ATPase activity
E0718_RS11725	COG1250	3-hydroxyacyl-CoA dehydrogenase
E0718_RS11730	COG2072	flavoprotein involved in K transport
E0718_RS11765	COG0559	Belongs to the binding-protein-dependent transport system permease family
E0718_RS11895	COG0248	Ppx GppA phosphatase
E0718_RS11915	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E0718_RS11925	COG1534	Rna-binding protein
E0718_RS11935	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E0718_RS11940	COG0840	transmembrane signaling receptor activity
E0718_RS11945	COG2233	PERMEase
E0718_RS11960	COG3842	ATPase activity
E0718_RS11970	COG0406	alpha-ribazole phosphatase activity
E0718_RS11975	COG4221	oxidoreductase activity
E0718_RS11990	COG0084	hydrolase, TatD family'
E0718_RS11995	COG1136	(ABC) transporter
E0718_RS12010	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E0718_RS12020	COG1028	Short-chain dehydrogenase reductase Sdr
E0718_RS12040	COG1022	Amp-dependent synthetase and ligase
E0718_RS12070	COG1024	Enoyl-CoA hydratase
E0718_RS12085	COG0633	Ferredoxin
E0718_RS12100	COG0316	Belongs to the HesB IscA family
E0718_RS12105	COG0822	iron-sulfur transferase activity
E0718_RS12110	COG1104	cysteine desulfurase activity
E0718_RS12120	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E0718_RS12140	COG3468	outer membrane autotransporter barrel domain protein
E0718_RS12150	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
E0718_RS12165	COG1960	acyl-CoA dehydrogenase activity
E0718_RS12170	COG1028	Short-chain dehydrogenase reductase Sdr
E0718_RS12185	COG1024	Enoyl-CoA hydratase
E0718_RS12200	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E0718_RS12205	COG0583	DNA-binding transcription factor activity
E0718_RS12210	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
E0718_RS12220	COG0740	serine-type endopeptidase activity
E0718_RS12235	COG1278	Cold shock
E0718_RS12245	COG1278	Cold shock
E0718_RS12275	COG0436	Aminotransferase
E0718_RS12290	COG2890	protein-(glutamine-N5) methyltransferase activity
E0718_RS12295	COG0488	(ABC) transporter
E0718_RS12300	COG4771	TonB-dependent receptor
E0718_RS12305	COG0210	DNA helicase
E0718_RS12320	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E0718_RS12320	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E0718_RS12325	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E0718_RS12330	COG0196	riboflavin kinase activity
E0718_RS12340	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
E0718_RS12345	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
E0718_RS12360	COG1522	sequence-specific DNA binding
E0718_RS12385	COG1126	abc transporter atp-binding protein
E0718_RS12390	COG0765	amino acid transport
E0718_RS12395	COG0765	amino acid transport
E0718_RS12400	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E0718_RS12410	COG2423	ornithine cyclodeaminase activity
E0718_RS12415	COG1764	response to oxidative stress
E0718_RS12425	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E0718_RS12430	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E0718_RS12445	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
E0718_RS12450	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E0718_RS12455	COG2197	response regulator
E0718_RS12465	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E0718_RS12525	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
E0718_RS12540	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
E0718_RS12565	COG1122	ATPase activity
E0718_RS12595	COG0437	4 iron, 4 sulfur cluster binding
E0718_RS12600	COG3383	formate dehydrogenase (NAD+) activity
E0718_RS12600	COG0243	molybdopterin cofactor binding
E0718_RS12630	COG0489	protein tyrosine kinase activity
E0718_RS12635	COG0746	molybdenum cofactor guanylyltransferase activity
E0718_RS12640	COG0303	'Molybdopterin
E0718_RS12645	COG1763	Mo-molybdopterin cofactor biosynthetic process
E0718_RS12660	COG5001	Diguanylate cyclase
E0718_RS12665	COG2205	protein histidine kinase activity
E0718_RS12670	COG0745	RESPONSE REGULATOR receiver
E0718_RS12685	COG1295	ribonuclease BN
E0718_RS12695	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E0718_RS12730	COG4964	Belongs to the GSP D family
E0718_RS12775	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E0718_RS12810	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
E0718_RS12815	COG3395	kinase activity
E0718_RS12855	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E0718_RS12860	COG2358	TRAP transporter, solute receptor (TAXI family
E0718_RS12870	COG2311	Membrane
E0718_RS12895	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
E0718_RS12910	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
E0718_RS12915	COG1760	l-serine dehydratase
E0718_RS12920	COG1283	sodium-dependent phosphate transmembrane transporter activity
E0718_RS12925	COG0412	Dienelactone hydrolase
E0718_RS12940	COG1611	Belongs to the LOG family
E0718_RS12975	COG0195	Participates in both transcription termination and antitermination
E0718_RS12975	COG2251	uridine kinase activity
E0718_RS12985	COG1187	pseudouridine synthase activity
E0718_RS12990	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
E0718_RS13000	COG0583	DNA-binding transcription factor activity
E0718_RS13010	COG0523	cobalamin synthesis protein
E0718_RS13030	COG0625	glutathione transferase activity
E0718_RS13035	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
E0718_RS13040	COG1047	Peptidyl-prolyl cis-trans
E0718_RS13100	COG2304	oxidoreductase activity
E0718_RS13120	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E0718_RS13125	COG1562	ergosterol biosynthetic process
E0718_RS13130	COG1562	ergosterol biosynthetic process
E0718_RS13135	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
E0718_RS13135	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
E0718_RS13155	COG1131	(ABC) transporter
E0718_RS13190	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
E0718_RS13205	COG5564	TIM-barrel signal transduction protein
E0718_RS13220	COG3468	outer membrane autotransporter barrel domain protein
E0718_RS13230	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E0718_RS13245	COG0494	nUDIX hydrolase
E0718_RS13250	COG3530	Putative quorum-sensing-regulated virulence factor
E0718_RS13260	COG1595	DNA-templated transcription, initiation
E0718_RS13265	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E0718_RS13300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E0718_RS13305	COG0765	amino acid transport
E0718_RS13310	COG0765	amino acid transport
E0718_RS13340	COG2841	Protein conserved in bacteria
E0718_RS13345	COG2814	Major facilitator Superfamily
E0718_RS13360	COG0628	permease
E0718_RS13365	COG0842	Transport permease protein
E0718_RS13370	COG1131	(ABC) transporter
E0718_RS13415	COG3278	Belongs to the heme-copper respiratory oxidase family
E0718_RS13445	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
E0718_RS13445	COG4106	trans-aconitate 2-methyltransferase activity
E0718_RS13450	COG1380	Effector of murein hydrolase LrgA
E0718_RS13455	COG1346	cytolysis
E0718_RS13465	COG2224	Isocitrate lyase
E0718_RS13480	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E0718_RS13495	COG0736	holo-[acyl-carrier-protein] synthase activity
E0718_RS13500	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
E0718_RS13515	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E0718_RS13540	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
E0718_RS13555	COG2032	superoxide dismutase activity
E0718_RS13565	COG0318	PFAM AMP-dependent synthetase and ligase
E0718_RS13570	COG1024	Enoyl-CoA hydratase
E0718_RS13580	COG1802	Transcriptional regulator
E0718_RS13590	COG0183	Belongs to the thiolase family
E0718_RS13595	COG1942	4-Oxalocrotonate Tautomerase
E0718_RS13605	COG4176	ABC-type proline glycine betaine transport system permease component
E0718_RS13615	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E0718_RS13620	COG2814	Major facilitator Superfamily
E0718_RS13625	COG0227	Belongs to the bacterial ribosomal protein bL28 family
E0718_RS13630	COG0267	Belongs to the bacterial ribosomal protein bL33 family
E0718_RS13650	COG2814	Major facilitator Superfamily
E0718_RS13680	COG0154	amidase activity
E0718_RS13685	COG1250	3-hydroxyacyl-CoA dehydrogenase
E0718_RS13725	COG1530	ribonuclease E activity
E0718_RS13730	COG0077	Prephenate dehydratase
E0718_RS13750	COG0859	PFAM glycosyl transferase family 9
E0718_RS13775	COG2194	sulfuric ester hydrolase activity
E0718_RS13780	COG0438	transferase activity, transferring glycosyl groups
E0718_RS13785	COG0463	Glycosyl transferase, family 2
E0718_RS13790	COG0726	polysaccharide deacetylase
E0718_RS13795	COG0438	transferase activity, transferring glycosyl groups
E0718_RS13810	COG1643	Atp-dependent helicase
E0718_RS13815	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
E0718_RS13815	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E0718_RS13820	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
E0718_RS13830	COG0704	Plays a role in the regulation of phosphate uptake
E0718_RS13840	COG1960	acyl-CoA dehydrogenase activity
E0718_RS13865	COG1177	transmembrane transport
E0718_RS13870	COG1176	ABC-type spermidine putrescine transport system, permease component I
E0718_RS13875	COG3842	ATPase activity
E0718_RS13880	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
E0718_RS13895	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
E0718_RS13900	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E0718_RS13910	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E0718_RS13910	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
E0718_RS13915	COG3539	Fimbrial protein
E0718_RS13920	COG3539	Fimbrial protein
E0718_RS13935	COG2050	protein possibly involved in aromatic compounds catabolism
E0718_RS13940	COG1024	Enoyl-CoA hydratase
E0718_RS13945	COG1012	belongs to the aldehyde dehydrogenase family
E0718_RS13950	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E0718_RS13955	COG2151	metal-sulfur cluster biosynthetic enzyme
E0718_RS13960	COG3396	Phenylacetate-CoA oxygenase
E0718_RS13965	COG3460	Phenylacetate-CoA oxygenase
E0718_RS13970	COG3396	Phenylacetate-CoA oxygenase
E0718_RS13975	COG3327	negative regulation of DNA-templated transcription, initiation
E0718_RS13985	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
E0718_RS13990	COG0501	Belongs to the peptidase M48B family
E0718_RS13995	COG1162	GTPase activity
E0718_RS14000	COG0667	Aldo Keto reductase
E0718_RS14010	COG0335	large ribosomal subunit rRNA binding
E0718_RS14040	COG0175	sulfate reduction
E0718_RS14050	COG4208	sulfate ABC transporter
E0718_RS14070	COG0602	queuosine metabolic process
E0718_RS14075	COG0720	synthase
E0718_RS14080	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
E0718_RS14085	COG0235	Class ii aldolase
E0718_RS14110	COG1566	PFAM secretion protein HlyD family protein
E0718_RS14120	COG0400	carboxylic ester hydrolase activity
E0718_RS14145	COG1959	2 iron, 2 sulfur cluster binding
E0718_RS14185	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E0718_RS14200	COG0667	Aldo Keto reductase
E0718_RS14210	COG5265	(ABC) transporter
E0718_RS14245	COG3468	outer membrane autotransporter barrel domain protein
E0718_RS14250	COG3468	outer membrane autotransporter barrel domain protein
E0718_RS14275	COG0840	transmembrane signaling receptor activity
E0718_RS14280	COG4943	cyclic-guanylate-specific phosphodiesterase activity
E0718_RS14285	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E0718_RS14315	COG0583	DNA-binding transcription factor activity
E0718_RS14325	COG2814	Major facilitator Superfamily
E0718_RS14340	COG1619	proteins homologs of microcin C7 resistance protein MccF
E0718_RS14355	COG2084	Dehydrogenase
E0718_RS14360	COG3181	Tripartite tricarboxylate transporter family receptor
E0718_RS14370	COG1253	flavin adenine dinucleotide binding
E0718_RS14385	COG2988	succinylglutamate desuccinylase activity
E0718_RS14410	COG0861	Integral membrane protein TerC family
E0718_RS14420	COG1595	DNA-templated transcription, initiation
E0718_RS14435	COG0076	glutamate decarboxylase activity
E0718_RS14440	COG0076	glutamate decarboxylase activity
E0718_RS14455	COG3189	MarR family transcriptional regulator
E0718_RS14485	COG0028	Belongs to the TPP enzyme family
E0718_RS14495	COG1012	belongs to the aldehyde dehydrogenase family
E0718_RS14500	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E0718_RS14510	COG1126	abc transporter atp-binding protein
E0718_RS14535	COG0084	hydrolase, TatD family'
E0718_RS14540	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
E0718_RS14545	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
E0718_RS14550	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E0718_RS14575	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
E0718_RS14580	COG1960	acyl-CoA dehydrogenase activity
E0718_RS14590	COG2867	negative regulation of translational initiation
E0718_RS14605	COG0330	HflC and HflK could
E0718_RS14630	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E0718_RS14635	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
E0718_RS14660	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
E0718_RS14665	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E0718_RS14670	COG0750	zinc metalloprotease
E0718_RS14685	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E0718_RS14690	COG0233	cytoplasmic translational termination
E0718_RS14705	COG0052	Belongs to the universal ribosomal protein uS2 family
E0718_RS14710	COG0024	Methionine aminopeptidase
E0718_RS14745	COG0285	dihydrofolate synthase activity
E0718_RS14775	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E0718_RS14785	COG1677	Flagellar hook-basal body complex protein FliE
E0718_RS14795	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E0718_RS14800	COG1317	bacterial-type flagellum organization
E0718_RS14805	COG1157	protein secretion by the type III secretion system
E0718_RS14820	COG1580	Controls the rotational direction of flagella during chemotaxis
E0718_RS14840	COG1338	Plays a role in the flagellum-specific transport system
E0718_RS14860	COG0840	transmembrane signaling receptor activity
E0718_RS14870	COG1256	bacterial-type flagellum assembly
E0718_RS14900	COG1749	Flagellar hook protein flgE
E0718_RS14910	COG1558	bacterial-type flagellum-dependent cell motility
E0718_RS14915	COG1815	bacterial-type flagellum-dependent cell motility
E0718_RS14950	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
E0718_RS14955	COG0745	RESPONSE REGULATOR receiver
E0718_RS14965	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
E0718_RS14970	COG0840	transmembrane signaling receptor activity
E0718_RS14980	COG0643	Histidine kinase
E0718_RS14980	COG2198	Histidine kinase
E0718_RS14985	COG0745	RESPONSE REGULATOR receiver
E0718_RS15015	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E0718_RS15020	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E0718_RS15025	COG0508	dehydrogenase complex catalyzes the overall conversion of
E0718_RS15030	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
E0718_RS15040	COG4566	intracellular signal transduction
E0718_RS15045	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
E0718_RS15050	COG0339	signal peptide processing
E0718_RS15055	COG1999	signal sequence binding
E0718_RS15075	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E0718_RS15085	COG1187	pseudouridine synthase activity
E0718_RS15090	COG3161	chorismate lyase activity
E0718_RS15105	COG1280	lysine exporter protein (LysE YggA)
E0718_RS15115	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E0718_RS15120	COG0601	transmembrane transport
E0718_RS15125	COG0747	negative chemotaxis
E0718_RS15170	COG0668	transmembrane transport
E0718_RS15175	COG0165	Argininosuccinate lyase
E0718_RS15185	COG0789	Transcriptional regulator
E0718_RS15195	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E0718_RS15200	COG0765	amino acid transport
E0718_RS15205	COG1126	abc transporter atp-binding protein
E0718_RS15215	COG2346	COG2346, Truncated hemoglobins
E0718_RS15275	COG1335	isochorismatase
E0718_RS15280	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E0718_RS15300	COG2837	iron assimilation
E0718_RS15330	COG4691	Plasmid stability protein
E0718_RS15365	COG0583	DNA-binding transcription factor activity
E0718_RS15370	COG2814	Major facilitator Superfamily
E0718_RS15380	COG0501	Belongs to the peptidase M48B family
E0718_RS15390	COG0583	DNA-binding transcription factor activity
E0718_RS15400	COG2188	Transcriptional regulator
E0718_RS15415	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E0718_RS15425	COG3181	Tripartite tricarboxylate transporter family receptor
E0718_RS15430	COG0129	dihydroxy-acid dehydratase activity
E0718_RS15445	COG0129	dihydroxy-acid dehydratase activity
E0718_RS15455	COG3622	Belongs to the hyi family
E0718_RS15460	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E0718_RS15465	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
E0718_RS15480	COG0583	DNA-binding transcription factor activity
E0718_RS15485	COG1250	3-hydroxyacyl-CoA dehydrogenase
E0718_RS15490	COG3246	L-lysine catabolic process to acetate
E0718_RS15525	COG0697	spore germination
E0718_RS15540	COG0625	glutathione transferase activity
E0718_RS15560	COG1280	lysine exporter protein (LysE YggA)
E0718_RS15565	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E0718_RS15600	COG2207	Transcriptional regulator
E0718_RS15640	COG1132	(ABC) transporter
E0718_RS15665	COG0659	secondary active sulfate transmembrane transporter activity
E0718_RS15700	COG5507	3-demethylubiquinone-9 3-methyltransferase
E0718_RS15705	COG0384	phenazine biosynthesis protein PhzF
E0718_RS15710	COG0583	DNA-binding transcription factor activity
E0718_RS15715	COG2733	membrane
E0718_RS15730	COG1012	belongs to the aldehyde dehydrogenase family
E0718_RS15735	COG3284	Transcriptional regulator
E0718_RS15740	COG0656	L-ascorbic acid biosynthetic process
E0718_RS15765	COG0842	Transport permease protein
E0718_RS15790	COG1802	Transcriptional regulator
E0718_RS15810	COG3181	Tripartite tricarboxylate transporter family receptor
E0718_RS15815	COG2188	Transcriptional regulator
E0718_RS15840	COG0789	Transcriptional regulator
E0718_RS15855	COG1609	Transcriptional regulator
E0718_RS15860	COG4172	Belongs to the ABC transporter superfamily
E0718_RS15870	COG0601	transmembrane transport
E0718_RS15875	COG0747	negative chemotaxis
E0718_RS15890	COG1280	lysine exporter protein (LysE YggA)
E0718_RS15930	COG1012	belongs to the aldehyde dehydrogenase family
E0718_RS15935	COG2079	MmgE PrpD family protein
E0718_RS15955	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E0718_RS15970	COG3618	amidohydrolase
E0718_RS15985	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
E0718_RS16000	COG0625	glutathione transferase activity
E0718_RS16015	COG2814	Major facilitator Superfamily
E0718_RS16020	COG0477	Major facilitator Superfamily
E0718_RS16040	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
E0718_RS16045	COG1061	Type III restriction enzyme res subunit
E0718_RS16085	COG2197	response regulator
E0718_RS16090	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E0718_RS16110	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E0718_RS16130	COG3181	Tripartite tricarboxylate transporter family receptor
E0718_RS16150	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
E0718_RS16150	COG3210	domain, Protein
E0718_RS16150	COG3064	Membrane
E0718_RS16155	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E0718_RS16155	COG0047	phosphoribosylformylglycinamidine synthase activity
E0718_RS16160	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
E0718_RS16165	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E0718_RS16165	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
E0718_RS16180	COG0613	PHP domain protein
E0718_RS16215	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
E0718_RS16220	COG0505	Belongs to the CarA family
E0718_RS16230	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E0718_RS16240	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E0718_RS16245	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E0718_RS16260	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
E0718_RS16270	COG1074	ATP-dependent DNA helicase activity
E0718_RS16285	COG2814	Major facilitator Superfamily
E0718_RS16295	COG1686	Belongs to the peptidase S11 family
E0718_RS16305	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
E0718_RS16310	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
E0718_RS16315	COG4974	Belongs to the 'phage' integrase family
E0718_RS16320	COG0583	DNA-binding transcription factor activity
E0718_RS16325	COG0028	Belongs to the TPP enzyme family
E0718_RS16345	COG1126	abc transporter atp-binding protein
E0718_RS16350	COG0765	amino acid transport
E0718_RS16365	COG1414	Transcriptional regulator
E0718_RS16370	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E0718_RS16375	COG0009	L-threonylcarbamoyladenylate synthase
E0718_RS16380	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
E0718_RS16385	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
E0718_RS16390	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
E0718_RS16410	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
E0718_RS16460	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
E0718_RS16470	COG0739	heme binding
E0718_RS16480	COG0521	Mo-molybdopterin cofactor biosynthetic process
E0718_RS16485	COG0306	phosphate transporter
E0718_RS16495	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
E0718_RS16525	COG0625	glutathione transferase activity
E0718_RS16540	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
E0718_RS16545	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E0718_RS16555	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E0718_RS16560	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E0718_RS16565	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E0718_RS16570	COG2732	(Barnase) inhibitor
E0718_RS16580	COG0281	malic enzyme
E0718_RS16580	COG0280	phosphate acetyltransferase
E0718_RS16590	COG0436	Aminotransferase
E0718_RS16595	COG0741	lytic transglycosylase activity
E0718_RS16640	COG2027	D-alanyl-D-alanine carboxypeptidase
E0718_RS16650	COG0343	queuine tRNA-ribosyltransferase activity
E0718_RS16655	COG1862	Preprotein translocase
E0718_RS16660	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E0718_RS16665	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E0718_RS16680	COG1702	phosphate starvation-inducible protein PhoH
E0718_RS16690	COG4535	Mg2 and Co2 transporter CorC
E0718_RS16700	COG0667	Aldo Keto reductase
E0718_RS16720	COG1802	Transcriptional regulator
E0718_RS16730	COG3181	Tripartite tricarboxylate transporter family receptor
E0718_RS16745	COG3181	Tripartite tricarboxylate transporter family receptor
E0718_RS16750	COG0523	cobalamin synthesis protein
E0718_RS16755	COG1335	isochorismatase
E0718_RS16760	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E0718_RS16765	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
E0718_RS16810	COG0697	spore germination
E0718_RS16820	COG0678	peroxiredoxin activity
E0718_RS16830	COG0412	Dienelactone hydrolase
E0718_RS16845	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
E0718_RS16855	COG0521	Mo-molybdopterin cofactor biosynthetic process
E0718_RS16860	COG0303	'Molybdopterin
E0718_RS16865	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
E0718_RS16885	COG3383	formate dehydrogenase (NAD+) activity
E0718_RS16900	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
E0718_RS16920	COG5006	permease, DMT superfamily
E0718_RS16935	COG0477	Major facilitator Superfamily
E0718_RS16940	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E0718_RS16945	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E0718_RS16950	COG1845	cytochrome c oxidase, subunit III
E0718_RS16955	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
E0718_RS16965	COG1028	Short-chain dehydrogenase reductase Sdr
E0718_RS16990	COG1666	GTP binding
E0718_RS17050	COG0477	Major facilitator Superfamily
E0718_RS17060	COG0640	Transcriptional regulator
E0718_RS17065	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
E0718_RS17070	COG1845	cytochrome c oxidase, subunit III
E0718_RS17075	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E0718_RS17085	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
E0718_RS17110	COG0583	DNA-binding transcription factor activity
E0718_RS17120	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E0718_RS17125	COG0583	DNA-binding transcription factor activity
E0718_RS17155	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E0718_RS17165	COG2900	Belongs to the SlyX family
E0718_RS17185	COG1917	Cupin 2, conserved barrel domain protein
E0718_RS17185	COG2207	Transcriptional regulator
E0718_RS17200	COG2070	2-Nitropropane dioxygenase
E0718_RS17210	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
E0718_RS17215	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E0718_RS17250	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
E0718_RS17255	COG0596	Alpha beta hydrolase
E0718_RS17285	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E0718_RS17295	COG1294	oxidase, subunit
E0718_RS17300	COG1271	oxidase subunit
E0718_RS17320	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E0718_RS17320	COG2169	Transcriptional regulator
E0718_RS17335	COG3945	hemerythrin HHE cation binding domain
E0718_RS17350	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E0718_RS17360	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
E0718_RS17360	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E0718_RS17365	COG0154	amidase activity
E0718_RS17385	COG2199	diguanylate cyclase activity
E0718_RS17385	COG2203	Gaf domain
E0718_RS17395	COG1024	Enoyl-CoA hydratase
E0718_RS17405	COG1012	belongs to the aldehyde dehydrogenase family
E0718_RS17430	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E0718_RS17445	COG0840	transmembrane signaling receptor activity
E0718_RS17465	COG1309	transcriptional regulator
E0718_RS17470	COG2076	Multidrug Resistance protein
E0718_RS17475	COG1028	Short-chain dehydrogenase reductase Sdr
E0718_RS17480	COG1960	acyl-CoA dehydrogenase activity
E0718_RS17485	COG1309	transcriptional regulator
E0718_RS17495	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E0718_RS17505	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
E0718_RS17515	COG0493	'glutamate synthase
E0718_RS17515	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
E0718_RS17520	COG1538	Outer membrane efflux protein
E0718_RS17530	COG2274	protein secretion by the type I secretion system
E0718_RS17535	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E0718_RS17560	COG1335	isochorismatase
E0718_RS17570	COG1418	mRNA catabolic process
E0718_RS17610	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E0718_RS17620	COG0318	PFAM AMP-dependent synthetase and ligase
E0718_RS17630	COG1522	sequence-specific DNA binding
E0718_RS17635	COG3181	Tripartite tricarboxylate transporter family receptor
E0718_RS17640	COG0307	riboflavin synthase, alpha
E0718_RS17645	COG2807	transmembrane transport
E0718_RS17650	COG0590	tRNA wobble adenosine to inosine editing
E0718_RS17660	COG0583	DNA-binding transcription factor activity
E0718_RS17665	COG1902	pentaerythritol trinitrate reductase activity
E0718_RS17685	COG0559	Belongs to the binding-protein-dependent transport system permease family
E0718_RS17690	COG0251	oxidation-reduction process
E0718_RS17695	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E0718_RS17710	COG1414	Transcriptional regulator
E0718_RS17715	COG1028	Short-chain dehydrogenase reductase Sdr
E0718_RS17730	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E0718_RS17740	COG1024	Enoyl-CoA hydratase
E0718_RS17745	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E0718_RS17750	COG0154	amidase activity
E0718_RS17775	COG2188	Transcriptional regulator
E0718_RS17780	COG3795	YCII-related domain
E0718_RS17785	COG0387	Pfam Sodium calcium exchanger
E0718_RS17795	COG3685	Protein conserved in bacteria
E0718_RS17835	COG1960	acyl-CoA dehydrogenase activity
E0718_RS17840	COG0318	PFAM AMP-dependent synthetase and ligase
E0718_RS17845	COG1024	Enoyl-CoA hydratase
E0718_RS17850	COG1024	Enoyl-CoA hydratase
E0718_RS17865	COG0318	PFAM AMP-dependent synthetase and ligase
E0718_RS17870	COG1250	3-hydroxyacyl-CoA dehydrogenase
E0718_RS17870	COG1024	Enoyl-CoA hydratase
E0718_RS17925	COG2199	diguanylate cyclase activity
E0718_RS17930	COG0583	DNA-binding transcription factor activity
E0718_RS17935	COG3181	Tripartite tricarboxylate transporter family receptor
E0718_RS17960	COG0583	DNA-binding transcription factor activity
E0718_RS17965	COG3181	Tripartite tricarboxylate transporter family receptor
E0718_RS17970	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E0718_RS17975	COG1960	acyl-CoA dehydrogenase activity
E0718_RS17990	COG0405	Gamma-glutamyltransferase
E0718_RS18005	COG1335	isochorismatase
E0718_RS18025	COG1414	Transcriptional regulator
E0718_RS18030	COG3181	Tripartite tricarboxylate transporter family receptor
E0718_RS18035	COG1053	succinate dehydrogenase
E0718_RS18040	COG0583	DNA-binding transcription factor activity
E0718_RS18050	COG1053	succinate dehydrogenase
E0718_RS18070	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
E0718_RS18095	COG1252	NADH dehydrogenase
E0718_RS18100	COG0284	orotidine-5'-phosphate decarboxylase activity
E0718_RS18105	COG1546	Belongs to the CinA family
E0718_RS18105	COG1058	Belongs to the CinA family
E0718_RS18110	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
E0718_RS18120	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E0718_RS18125	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
E0718_RS18155	COG3639	organic phosphonate transmembrane transporter activity
E0718_RS18160	COG3639	organic phosphonate transmembrane transporter activity
E0718_RS18175	COG0742	ribosomal rna small subunit methyltransferase
E0718_RS18180	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
E0718_RS18185	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E0718_RS18190	COG3135	benzoate transporter
E0718_RS18205	COG0640	Transcriptional regulator
E0718_RS18220	COG0583	DNA-binding transcription factor activity
E0718_RS18230	COG0747	negative chemotaxis
E0718_RS18235	COG4172	Belongs to the ABC transporter superfamily
E0718_RS18240	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E0718_RS18245	COG0601	transmembrane transport
E0718_RS18255	COG0281	malic enzyme
E0718_RS18255	COG0280	phosphate acetyltransferase
E0718_RS18280	COG2814	Major facilitator Superfamily
E0718_RS18290	COG1309	transcriptional regulator
E0718_RS18295	COG3181	Tripartite tricarboxylate transporter family receptor
E0718_RS18315	COG0012	GTP binding
E0718_RS18400	COG1368	sulfuric ester hydrolase activity
E0718_RS18405	COG0642	Histidine kinase
E0718_RS18410	COG0745	RESPONSE REGULATOR receiver
E0718_RS18415	COG0277	FAD linked oxidase domain protein
E0718_RS18430	COG0166	Belongs to the GPI family
E0718_RS18435	COG0438	transferase activity, transferring glycosyl groups
E0718_RS18440	COG0438	transferase activity, transferring glycosyl groups
E0718_RS18455	COG0438	transferase activity, transferring glycosyl groups
E0718_RS18470	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
E0718_RS18475	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E0718_RS18505	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E0718_RS18515	COG0747	negative chemotaxis
E0718_RS18520	COG0601	transmembrane transport
E0718_RS18525	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E0718_RS18530	COG4172	Belongs to the ABC transporter superfamily
E0718_RS18550	COG1024	Enoyl-CoA hydratase
E0718_RS18575	COG0509	glycine decarboxylation via glycine cleavage system
E0718_RS18590	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
E0718_RS18595	COG2081	HI0933 family
E0718_RS18640	COG0489	protein tyrosine kinase activity
E0718_RS18685	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E0718_RS18745	COG3468	outer membrane autotransporter barrel domain protein
E0718_RS18920	COG3135	benzoate transporter
E0718_RS18935	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
E0718_RS18995	COG0154	amidase activity
E0718_RS19005	COG1414	Transcriptional regulator
E0718_RS19010	COG1473	amidohydrolase
E0718_RS19020	COG0765	amino acid transport
E0718_RS19025	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E0718_RS19030	COG0436	Aminotransferase
E0718_RS19035	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E0718_RS19075	COG0626	cystathionine gamma-synthase activity
E0718_RS19080	COG1012	belongs to the aldehyde dehydrogenase family
E0718_RS19085	COG2186	Transcriptional regulator
E0718_RS19095	COG3181	Tripartite tricarboxylate transporter family receptor
E0718_RS19100	COG0625	glutathione transferase activity
E0718_RS19115	COG2267	carboxylic ester hydrolase activity
E0718_RS19120	COG0583	DNA-binding transcription factor activity
E0718_RS19135	COG3181	Tripartite tricarboxylate transporter family receptor
E0718_RS19140	COG0183	Belongs to the thiolase family
E0718_RS19145	COG1024	Enoyl-CoA hydratase
E0718_RS19150	COG1960	acyl-CoA dehydrogenase activity
E0718_RS19165	COG1024	Enoyl-CoA hydratase
E0718_RS19185	COG0318	PFAM AMP-dependent synthetase and ligase
E0718_RS19190	COG1960	acyl-CoA dehydrogenase activity
E0718_RS19215	COG3181	Tripartite tricarboxylate transporter family receptor
E0718_RS19220	COG1028	Short-chain dehydrogenase reductase Sdr
E0718_RS19225	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E0718_RS19230	COG1414	Transcriptional regulator
E0718_RS19245	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
E0718_RS19250	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E0718_RS19255	COG0431	NADPH-dependent FMN reductase
E0718_RS19260	COG1012	belongs to the aldehyde dehydrogenase family
E0718_RS19280	COG1024	Enoyl-CoA hydratase
E0718_RS19285	COG1454	alcohol dehydrogenase
E0718_RS19290	COG3181	Tripartite tricarboxylate transporter family receptor
E0718_RS19295	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E0718_RS19300	COG1024	Enoyl-CoA hydratase
E0718_RS19320	COG1024	Enoyl-CoA hydratase
E0718_RS19330	COG1309	transcriptional regulator
E0718_RS19355	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
E0718_RS19370	COG1960	acyl-CoA dehydrogenase activity
E0718_RS19375	COG0583	DNA-binding transcription factor activity
E0718_RS19380	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E0718_RS19390	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E0718_RS19395	COG0183	Belongs to the thiolase family
E0718_RS19415	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
E0718_RS19430	COG0318	PFAM AMP-dependent synthetase and ligase
E0718_RS19435	COG0427	acetyl-CoA hydrolase
E0718_RS19450	COG0446	pyridine nucleotide-disulphide oxidoreductase
E0718_RS19450	COG1902	pentaerythritol trinitrate reductase activity
E0718_RS19470	COG0559	Belongs to the binding-protein-dependent transport system permease family
E0718_RS19495	COG3181	Tripartite tricarboxylate transporter family receptor
E0718_RS19500	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E0718_RS19505	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E0718_RS19515	COG2030	dehydratase
E0718_RS19525	COG1053	succinate dehydrogenase
E0718_RS19530	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
E0718_RS19540	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
E0718_RS19550	COG0318	PFAM AMP-dependent synthetase and ligase
E0718_RS19555	COG1028	Short-chain dehydrogenase reductase Sdr
E0718_RS19560	COG1960	acyl-CoA dehydrogenase activity
E0718_RS19565	COG1028	Short-chain dehydrogenase reductase Sdr
E0718_RS19595	COG0683	leucine binding
E0718_RS19630	COG1053	succinate dehydrogenase
E0718_RS19630	COG3976	FMN-binding domain protein
E0718_RS19640	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
E0718_RS19645	COG0066	3-isopropylmalate dehydratase activity
E0718_RS19655	COG1960	acyl-CoA dehydrogenase activity
E0718_RS19670	COG0583	DNA-binding transcription factor activity
E0718_RS19675	COG3181	Tripartite tricarboxylate transporter family receptor
E0718_RS19680	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E0718_RS19695	COG1024	Enoyl-CoA hydratase
E0718_RS19700	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E0718_RS19725	COG1609	Transcriptional regulator
E0718_RS19730	COG0318	PFAM AMP-dependent synthetase and ligase
E0718_RS19750	COG1414	Transcriptional regulator
E0718_RS19755	COG3181	Tripartite tricarboxylate transporter family receptor
E0718_RS19760	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E0718_RS19765	COG0028	Belongs to the TPP enzyme family
E0718_RS19790	COG3181	Tripartite tricarboxylate transporter family receptor
E0718_RS19795	COG1024	Enoyl-CoA hydratase
E0718_RS19805	COG3181	Tripartite tricarboxylate transporter family receptor
E0718_RS19810	COG0583	DNA-binding transcription factor activity
E0718_RS19870	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E0718_RS19905	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E0718_RS19910	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E0718_RS19935	COG1652	LysM domain
E0718_RS19940	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E0718_RS19945	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E0718_RS19960	COG0625	glutathione transferase activity
E0718_RS20035	COG1819	glycosyl
E0718_RS20040	COG0523	cobalamin synthesis protein
E0718_RS20045	COG1228	amidohydrolase
E0718_RS20060	COG3119	arylsulfatase activity
E0718_RS20070	COG0583	DNA-binding transcription factor activity
E0718_RS20075	COG1278	Cold shock
E0718_RS20105	COG2031	fatty acid transporter
E0718_RS20110	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E0718_RS20110	COG1017	nitric oxide dioxygenase activity
E0718_RS20120	COG0251	oxidation-reduction process
E0718_RS20135	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E0718_RS20145	COG0583	DNA-binding transcription factor activity
E0718_RS20150	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E0718_RS20155	COG0604	alcohol dehydrogenase
E0718_RS20160	COG3181	Tripartite tricarboxylate transporter family receptor
E0718_RS20165	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E0718_RS20170	COG1024	Enoyl-CoA hydratase
E0718_RS20175	COG1414	Transcriptional regulator
E0718_RS20180	COG0318	PFAM AMP-dependent synthetase and ligase
E0718_RS20185	COG3181	Tripartite tricarboxylate transporter family receptor
E0718_RS20215	COG0583	DNA-binding transcription factor activity
E0718_RS20230	COG3422	double-strand break repair
E0718_RS20235	COG0330	HflC and HflK could
E0718_RS20245	COG0251	oxidation-reduction process
E0718_RS20250	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E0718_RS20260	COG0628	permease
E0718_RS20265	COG0583	DNA-binding transcription factor activity
E0718_RS20280	COG1538	Outer membrane efflux protein
E0718_RS20305	COG2207	Transcriptional regulator
E0718_RS20310	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E0718_RS20320	COG0657	acetylesterase activity
E0718_RS20325	COG0747	negative chemotaxis
E0718_RS20330	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E0718_RS20335	COG2808	Putative FMN-binding domain
E0718_RS20365	COG1250	3-hydroxyacyl-CoA dehydrogenase
E0718_RS20370	COG2031	fatty acid transporter
E0718_RS20375	COG1028	Short-chain dehydrogenase reductase Sdr
E0718_RS20380	COG1414	Transcriptional regulator
E0718_RS20390	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
E0718_RS20405	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E0718_RS20425	COG0288	reversible hydration of carbon dioxide
E0718_RS20430	COG0154	amidase activity
E0718_RS20435	COG0683	leucine binding
E0718_RS20445	COG4211	Belongs to the binding-protein-dependent transport system permease family
E0718_RS20515	COG3181	Tripartite tricarboxylate transporter family receptor
E0718_RS20525	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
E0718_RS20530	COG2890	protein-(glutamine-N5) methyltransferase activity
E0718_RS20570	COG0745	RESPONSE REGULATOR receiver
E0718_RS20595	COG1902	pentaerythritol trinitrate reductase activity
E0718_RS20610	COG1028	Short-chain dehydrogenase reductase Sdr
E0718_RS20645	COG1024	Enoyl-CoA hydratase
E0718_RS20650	COG0583	DNA-binding transcription factor activity
E0718_RS20695	COG2188	Transcriptional regulator
E0718_RS20700	COG2301	Belongs to the HpcH HpaI aldolase family
E0718_RS20705	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E0718_RS20710	COG0583	DNA-binding transcription factor activity
E0718_RS20740	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E0718_RS20750	COG0318	PFAM AMP-dependent synthetase and ligase
E0718_RS20760	COG1802	Transcriptional regulator
E0718_RS20775	COG1802	Transcriptional regulator
E0718_RS20785	COG1028	Short-chain dehydrogenase reductase Sdr
E0718_RS20805	COG1126	abc transporter atp-binding protein
E0718_RS20810	COG0765	amino acid transport
E0718_RS20815	COG0765	amino acid transport
E0718_RS20835	COG1538	Outer membrane efflux protein
E0718_RS20840	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E0718_RS20845	COG2274	protein secretion by the type I secretion system
E0718_RS20850	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
E0718_RS20860	COG2994	toxin metabolic process
E0718_RS20875	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E0718_RS20880	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
E0718_RS20890	COG0583	DNA-binding transcription factor activity
E0718_RS20900	COG0142	geranyltranstransferase activity
E0718_RS20910	COG0261	This protein binds to 23S rRNA in the presence of protein L20
E0718_RS20915	COG0211	Belongs to the bacterial ribosomal protein bL27 family
E0718_RS20920	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
E0718_RS20955	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E0718_RS20975	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E0718_RS20980	COG0793	Belongs to the peptidase S41A family
E0718_RS20985	COG4942	peptidase
E0718_RS20995	COG1054	Belongs to the UPF0176 family
E0718_RS21000	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
E0718_RS21005	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
E0718_RS21015	COG3181	Tripartite tricarboxylate transporter family receptor
E0718_RS21030	COG2226	methyltransferase
E0718_RS21050	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E0718_RS21055	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
E0718_RS21080	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
E0718_RS21105	COG1335	isochorismatase
E0718_RS21110	COG2309	aminopeptidase activity
E0718_RS21115	COG0596	Alpha beta hydrolase
E0718_RS21120	COG3473	Maleate cis-trans isomerase
E0718_RS21130	COG2068	MobA-Related Protein
E0718_RS21155	COG2204	response regulator
E0718_RS21160	COG5000	phosphorelay sensor kinase activity
E0718_RS21170	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E0718_RS21170	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E0718_RS21205	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E0718_RS21210	COG1942	4-Oxalocrotonate Tautomerase
E0718_RS21215	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E0718_RS21235	COG0546	phosphoglycolate phosphatase activity
E0718_RS21250	COG0242	peptide deformylase activity
E0718_RS21260	COG1522	sequence-specific DNA binding
E0718_RS21265	COG0758	DNA mediated transformation
E0718_RS21280	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E0718_RS21285	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E0718_RS21290	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
E0718_RS21305	COG0583	DNA-binding transcription factor activity
E0718_RS21365	COG0640	Transcriptional regulator
E0718_RS21390	COG0438	transferase activity, transferring glycosyl groups
E0718_RS21410	COG0735	belongs to the Fur family
E0718_RS21425	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E0718_RS21430	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E0718_RS21440	COG0513	Belongs to the DEAD box helicase family
E0718_RS21465	COG0477	Major facilitator Superfamily
E0718_RS21475	COG0583	DNA-binding transcription factor activity
E0718_RS21485	COG1950	PFAM Membrane protein of
E0718_RS21505	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
E0718_RS21515	COG1560	Kdo2-lipid A biosynthetic process
E0718_RS21520	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
E0718_RS21530	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
E0718_RS21540	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
E0718_RS21550	COG0803	Belongs to the bacterial solute-binding protein 9 family
E0718_RS21560	COG1121	(ABC) transporter
E0718_RS21570	COG0735	belongs to the Fur family
E0718_RS21575	COG0523	cobalamin synthesis protein
E0718_RS21600	COG2096	Adenosyltransferase
E0718_RS21640	COG1686	Belongs to the peptidase S11 family
E0718_RS21660	COG1127	ABC transporter
E0718_RS21665	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
E0718_RS21690	COG0859	PFAM glycosyl transferase family 9
E0718_RS21720	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E0718_RS21725	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E0718_RS21730	COG0438	transferase activity, transferring glycosyl groups
E0718_RS21750	COG0438	transferase activity, transferring glycosyl groups
E0718_RS21760	COG0367	asparagine synthase
E0718_RS21785	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
E0718_RS21790	COG0367	asparagine synthase
E0718_RS21830	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E0718_RS21835	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E0718_RS21855	COG0367	asparagine synthase
E0718_RS21865	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E0718_RS21885	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E0718_RS21890	COG3568	Endonuclease Exonuclease Phosphatase
E0718_RS21895	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
E0718_RS21925	COG0531	amino acid
E0718_RS21955	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E0718_RS21960	COG1956	GAF domain-containing protein
E0718_RS21965	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E0718_RS21985	COG2186	Transcriptional regulator
E0718_RS22010	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E0718_RS22030	COG0438	transferase activity, transferring glycosyl groups
E0718_RS22040	COG0402	S-adenosylhomocysteine deaminase activity
E0718_RS22085	COG2814	Major facilitator Superfamily
E0718_RS22105	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
E0718_RS22110	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
E0718_RS22135	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E0718_RS22140	COG1333	cytochrome c biogenesis protein
E0718_RS22150	COG0218	Necessary for normal cell division and for the maintenance of normal septation
E0718_RS22165	COG4232	protein-disulfide reductase activity
E0718_RS22170	COG1324	tolerance protein
E0718_RS22175	COG0537	adenosine 5'-monophosphoramidase activity
E0718_RS22180	COG0203	ribosomal protein L17
E0718_RS22185	COG0202	RNA polymerase activity
E0718_RS22190	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
E0718_RS22195	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
E0718_RS22200	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
E0718_RS22205	COG0257	Belongs to the bacterial ribosomal protein bL36 family
E0718_RS22210	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
E0718_RS22215	COG0201	protein transport
E0718_RS22225	COG1841	ribosomal large subunit assembly
E0718_RS22230	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
E0718_RS22235	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
E0718_RS22245	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
E0718_RS22250	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
E0718_RS22255	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
E0718_RS22260	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
E0718_RS22265	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
E0718_RS22285	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
E0718_RS22290	COG0255	Belongs to the universal ribosomal protein uL29 family
E0718_RS22295	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
E0718_RS22300	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
E0718_RS22305	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
E0718_RS22315	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
E0718_RS22320	COG0089	rRNA binding
E0718_RS22330	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
E0718_RS22340	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E0718_RS22350	COG0049	tRNA binding
E0718_RS22355	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
E0718_RS22365	COG1230	cation diffusion facilitator family transporter
E0718_RS22405	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
E0718_RS22415	COG0222	ribosome binding
E0718_RS22420	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
E0718_RS22425	COG0081	regulation of translation
E0718_RS22440	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E0718_RS22450	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E0718_RS22470	COG0252	asparaginase activity
E0718_RS22475	COG1475	DNA binding
E0718_RS22485	COG1192	Involved in chromosome partitioning
E0718_RS22490	COG0357	Ribosomal RNA small subunit methyltransferase G
E0718_RS22500	COG1278	Cold shock
E0718_RS22505	COG0436	Aminotransferase
E0718_RS22545	COG0747	negative chemotaxis
E0718_RS22550	COG0601	transmembrane transport
E0718_RS22560	COG0444	Belongs to the ABC transporter superfamily
E0718_RS22565	COG4608	Belongs to the ABC transporter superfamily
E0718_RS22570	COG1473	amidohydrolase
E0718_RS22575	COG2175	clavaminate synthase activity
E0718_RS22585	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
E0718_RS22590	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E0718_RS22595	COG0753	catalase activity
E0718_RS22605	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
E0718_RS22610	COG0594	ribonuclease P activity
E0718_RS22615	COG0230	Belongs to the bacterial ribosomal protein bL34 family
E0718_RS22650	COG0583	DNA-binding transcription factor activity
E0718_RS22660	COG1028	Short-chain dehydrogenase reductase Sdr