locus-tag	class	description
B1865_RS00005	COG0445	tRNA wobble uridine modification
B1865_RS00010	COG0357	Ribosomal RNA small subunit methyltransferase G
B1865_RS00015	COG1192	Involved in chromosome partitioning
B1865_RS00025	COG1475	DNA binding
B1865_RS00030	COG0252	asparaginase activity
B1865_RS00055	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B1865_RS00065	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
B1865_RS00075	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
B1865_RS00080	COG0081	regulation of translation
B1865_RS00085	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
B1865_RS00090	COG0222	ribosome binding
B1865_RS00095	COG0085	RNA polymerase activity
B1865_RS00100	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
B1865_RS00140	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B1865_RS00165	COG1024	Enoyl-CoA hydratase
B1865_RS00185	COG0752	glycyl-tRNA synthetase alpha subunit
B1865_RS00190	COG0751	glycine-tRNA ligase activity
B1865_RS00195	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
B1865_RS00200	COG0204	Acyl-transferase
B1865_RS00215	COG0242	peptide deformylase activity
B1865_RS00250	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
B1865_RS00255	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
B1865_RS00260	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
B1865_RS00260	COG2813	Specifically methylates the guanine in position
B1865_RS00270	COG2223	nitrite transmembrane transporter activity
B1865_RS00280	COG1794	racemase activity, acting on amino acids and derivatives
B1865_RS00285	COG1126	abc transporter atp-binding protein
B1865_RS00290	COG0765	amino acid transport
B1865_RS00295	COG0765	amino acid transport
B1865_RS00300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B1865_RS00355	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
B1865_RS00385	COG0326	Molecular chaperone. Has ATPase activity
B1865_RS00390	COG0625	glutathione transferase activity
B1865_RS00405	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B1865_RS00410	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
B1865_RS00440	COG0438	transferase activity, transferring glycosyl groups
B1865_RS00445	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
B1865_RS00450	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
B1865_RS00480	COG0859	PFAM glycosyl transferase family 9
B1865_RS00495	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
B1865_RS00505	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
B1865_RS00510	COG1127	ABC transporter
B1865_RS00535	COG1686	Belongs to the peptidase S11 family
B1865_RS00545	COG2921	Belongs to the UPF0250 family
B1865_RS00550	COG0321	lipoyl(octanoyl) transferase activity
B1865_RS00555	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
B1865_RS00590	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
B1865_RS00600	COG0018	arginyl-trna synthetase
B1865_RS00620	COG0395	ABC-type sugar transport system, permease component
B1865_RS00625	COG1175	transmembrane transport
B1865_RS00630	COG1653	transport
B1865_RS00635	COG3842	ATPase activity
B1865_RS00640	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
B1865_RS00650	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
B1865_RS00670	COG1609	Transcriptional regulator
B1865_RS00680	COG0154	amidase activity
B1865_RS00685	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B1865_RS00695	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
B1865_RS00705	COG0583	DNA-binding transcription factor activity
B1865_RS00720	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
B1865_RS00725	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
B1865_RS00740	COG1802	Transcriptional regulator
B1865_RS00755	COG1024	Enoyl-CoA hydratase
B1865_RS00770	COG3181	Tripartite tricarboxylate transporter family receptor
B1865_RS00785	COG1984	allophanate hydrolase subunit 2
B1865_RS00790	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
B1865_RS00800	COG0583	DNA-binding transcription factor activity
B1865_RS00805	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B1865_RS00815	COG5002	protein histidine kinase activity
B1865_RS00825	COG5002	protein histidine kinase activity
B1865_RS00830	COG0745	RESPONSE REGULATOR receiver
B1865_RS00835	COG2226	methyltransferase
B1865_RS00850	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
B1865_RS00870	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
B1865_RS00880	COG0513	Belongs to the DEAD box helicase family
B1865_RS00885	COG1280	lysine exporter protein (LysE YggA)
B1865_RS00890	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
B1865_RS00925	COG1054	Belongs to the UPF0176 family
B1865_RS00930	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B1865_RS00930	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B1865_RS00940	COG0489	protein tyrosine kinase activity
B1865_RS00955	COG0717	Belongs to the dCTP deaminase family
B1865_RS00985	COG2081	HI0933 family
B1865_RS00995	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
B1865_RS01005	COG0404	The glycine cleavage system catalyzes the degradation of glycine
B1865_RS01010	COG0509	glycine decarboxylation via glycine cleavage system
B1865_RS01015	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B1865_RS01015	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B1865_RS01055	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
B1865_RS01070	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
B1865_RS01080	COG1414	Transcriptional regulator
B1865_RS01085	COG1028	Short-chain dehydrogenase reductase Sdr
B1865_RS01090	COG2031	fatty acid transporter
B1865_RS01095	COG1250	3-hydroxyacyl-CoA dehydrogenase
B1865_RS01105	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
B1865_RS01110	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
B1865_RS01120	COG4257	antibiotic catabolic process
B1865_RS01140	COG1012	belongs to the aldehyde dehydrogenase family
B1865_RS01145	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
B1865_RS01150	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B1865_RS01175	COG1028	Short-chain dehydrogenase reductase Sdr
B1865_RS01185	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B1865_RS01195	COG2188	Transcriptional regulator
B1865_RS01200	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
B1865_RS01225	COG0617	tRNA 3'-terminal CCA addition
B1865_RS01240	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
B1865_RS01245	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
B1865_RS01250	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
B1865_RS01255	COG0586	Pfam SNARE associated Golgi protein
B1865_RS01260	COG0860	N-Acetylmuramoyl-L-alanine amidase
B1865_RS01265	COG0802	atpase or kinase
B1865_RS01270	COG0114	fumarate hydratase activity
B1865_RS01280	COG3181	Tripartite tricarboxylate transporter family receptor
B1865_RS01290	COG0405	Gamma-glutamyltransferase
B1865_RS01295	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B1865_RS01305	COG1960	acyl-CoA dehydrogenase activity
B1865_RS01330	COG1294	oxidase, subunit
B1865_RS01340	COG4988	ABC transporter
B1865_RS01345	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
B1865_RS01350	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B1865_RS01365	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
B1865_RS01390	COG2969	positive regulation of protein catabolic process
B1865_RS01395	COG0625	glutathione transferase activity
B1865_RS01400	COG2857	Cytochrome c1
B1865_RS01405	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
B1865_RS01410	COG0723	plastoquinol--plastocyanin reductase activity
B1865_RS01415	COG1970	mechanosensitive ion channel activity
B1865_RS01420	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
B1865_RS01435	COG2808	Putative FMN-binding domain
B1865_RS01440	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B1865_RS01445	COG0747	negative chemotaxis
B1865_RS01450	COG0657	acetylesterase activity
B1865_RS01460	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B1865_RS01465	COG2207	Transcriptional regulator
B1865_RS01470	COG0129	dihydroxy-acid dehydratase activity
B1865_RS01475	COG2814	Major facilitator Superfamily
B1865_RS01480	COG0583	DNA-binding transcription factor activity
B1865_RS01490	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
B1865_RS01560	COG1024	Enoyl-CoA hydratase
B1865_RS01565	COG1960	acyl-CoA dehydrogenase activity
B1865_RS01590	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
B1865_RS01595	COG0352	thiamine-phosphate diphosphorylase activity
B1865_RS01610	COG1678	Uncharacterized ACR, COG1678
B1865_RS01615	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
B1865_RS01620	COG0540	Belongs to the ATCase OTCase family
B1865_RS01635	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
B1865_RS01645	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B1865_RS01680	COG1234	tRNA 3'-trailer cleavage
B1865_RS01725	COG1683	Conserved Protein
B1865_RS01730	COG1120	ATPase activity
B1865_RS01735	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B1865_RS01740	COG4558	Periplasmic binding protein
B1865_RS01745	COG3720	iron ion transport
B1865_RS01755	COG3712	iron ion homeostasis
B1865_RS01760	COG1595	DNA-templated transcription, initiation
B1865_RS01795	COG1802	Transcriptional regulator
B1865_RS01805	COG3069	C4-dicarboxylate transmembrane transporter activity
B1865_RS01815	COG1012	belongs to the aldehyde dehydrogenase family
B1865_RS01850	COG2860	membrane
B1865_RS01855	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
B1865_RS01860	COG0708	Exodeoxyribonuclease III
B1865_RS01865	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
B1865_RS01870	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B1865_RS01875	COG0154	amidase activity
B1865_RS01880	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B1865_RS01885	COG1077	Cell shape determining protein MreB Mrl
B1865_RS01890	COG1792	Involved in formation and maintenance of cell shape
B1865_RS01900	COG0768	penicillin binding
B1865_RS01905	COG0772	Belongs to the SEDS family
B1865_RS01910	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
B1865_RS01915	COG0471	metal ion transport
B1865_RS01920	COG1309	transcriptional regulator
B1865_RS01930	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
B1865_RS01945	COG2823	Periplasmic or secreted lipoprotein
B1865_RS01950	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
B1865_RS01965	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
B1865_RS01985	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B1865_RS01995	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B1865_RS02020	COG0492	ferredoxin-NADP+ reductase activity
B1865_RS02030	COG3181	Tripartite tricarboxylate transporter family receptor
B1865_RS02035	COG1024	Enoyl-CoA hydratase
B1865_RS02035	COG1250	3-hydroxyacyl-CoA dehydrogenase
B1865_RS02040	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B1865_RS02045	COG0028	Belongs to the TPP enzyme family
B1865_RS02070	COG3181	Tripartite tricarboxylate transporter family receptor
B1865_RS02080	COG0697	spore germination
B1865_RS02105	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
B1865_RS02110	COG0463	Glycosyl transferase, family 2
B1865_RS02125	COG0786	glutamate:sodium symporter activity
B1865_RS02135	COG2031	fatty acid transporter
B1865_RS02150	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
B1865_RS02155	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B1865_RS02175	COG3181	Tripartite tricarboxylate transporter family receptor
B1865_RS02185	COG0277	FAD linked oxidase domain protein
B1865_RS02190	COG1960	acyl-CoA dehydrogenase activity
B1865_RS02195	COG1960	acyl-CoA dehydrogenase activity
B1865_RS02205	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B1865_RS02220	COG2072	flavoprotein involved in K transport
B1865_RS02225	COG0604	alcohol dehydrogenase
B1865_RS02240	COG1024	Enoyl-CoA hydratase
B1865_RS02260	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B1865_RS02265	COG1522	sequence-specific DNA binding
B1865_RS02270	COG0183	Belongs to the thiolase family
B1865_RS02280	COG1960	acyl-CoA dehydrogenase activity
B1865_RS02320	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
B1865_RS02325	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
B1865_RS02330	COG2890	protein-(glutamine-N5) methyltransferase activity
B1865_RS02335	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
B1865_RS02345	COG3181	Tripartite tricarboxylate transporter family receptor
B1865_RS02385	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
B1865_RS02390	COG1660	Displays ATPase and GTPase activities
B1865_RS02400	COG1529	Aldehyde oxidase and xanthine dehydrogenase
B1865_RS02400	COG2010	Cytochrome c
B1865_RS02405	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
B1865_RS02420	COG1137	ATPase activity
B1865_RS02435	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
B1865_RS02445	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
B1865_RS02485	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
B1865_RS02490	COG3568	Endonuclease Exonuclease Phosphatase
B1865_RS02495	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B1865_RS02525	COG0154	amidase activity
B1865_RS02535	COG1414	Transcriptional regulator
B1865_RS02550	COG1250	3-hydroxyacyl-CoA dehydrogenase
B1865_RS02550	COG1024	Enoyl-CoA hydratase
B1865_RS02560	COG2132	Multicopper oxidase
B1865_RS02590	COG1250	3-hydroxyacyl-CoA dehydrogenase
B1865_RS02615	COG1024	Enoyl-CoA hydratase
B1865_RS02620	COG1024	Enoyl-CoA hydratase
B1865_RS02625	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
B1865_RS02645	COG0601	transmembrane transport
B1865_RS02650	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B1865_RS02655	COG4172	Belongs to the ABC transporter superfamily
B1865_RS02665	COG2195	Cleaves the N-terminal amino acid of tripeptides
B1865_RS02675	COG0210	DNA helicase
B1865_RS02680	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
B1865_RS02685	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
B1865_RS02695	COG0355	proton-transporting ATP synthase activity, rotational mechanism
B1865_RS02700	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
B1865_RS02705	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
B1865_RS02710	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
B1865_RS02715	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B1865_RS02720	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
B1865_RS02730	COG0356	it plays a direct role in the translocation of protons across the membrane
B1865_RS02755	COG1024	Enoyl-CoA hydratase
B1865_RS02760	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B1865_RS02765	COG3634	alkyl hydroperoxide reductase activity
B1865_RS02775	COG0037	tRNA processing
B1865_RS02785	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B1865_RS02790	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
B1865_RS02795	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B1865_RS02800	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
B1865_RS02805	COG2967	ApaG domain
B1865_RS02810	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
B1865_RS02815	COG0546	phosphoglycolate phosphatase activity
B1865_RS02825	COG0512	Glutamine amidotransferase of anthranilate synthase
B1865_RS02830	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
B1865_RS02835	COG0134	indole-3-glycerol-phosphate synthase activity
B1865_RS02860	COG1960	acyl-CoA dehydrogenase activity
B1865_RS02865	COG0583	DNA-binding transcription factor activity
B1865_RS02880	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
B1865_RS02885	COG0259	pyridoxamine-phosphate oxidase activity
B1865_RS02895	COG2814	Major facilitator Superfamily
B1865_RS02900	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
B1865_RS02905	COG2188	Transcriptional regulator
B1865_RS02910	COG0318	PFAM AMP-dependent synthetase and ligase
B1865_RS02930	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B1865_RS02940	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
B1865_RS02955	COG1215	transferase activity, transferring glycosyl groups
B1865_RS02965	COG0601	transmembrane transport
B1865_RS02975	COG0488	(ABC) transporter
B1865_RS02995	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
B1865_RS03000	COG2894	cell division
B1865_RS03005	COG0850	regulation of cytokinetic process
B1865_RS03010	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B1865_RS03015	COG1271	oxidase subunit
B1865_RS03050	COG2979	Protein of unknown function (DUF533)
B1865_RS03070	COG0741	lytic transglycosylase activity
B1865_RS03070	COG1388	LysM domain
B1865_RS03075	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B1865_RS03080	COG2226	methyltransferase
B1865_RS03085	COG0328	RNA-DNA hybrid ribonuclease activity
B1865_RS03130	COG2030	dehydratase
B1865_RS03135	COG0183	Belongs to the thiolase family
B1865_RS03180	COG1960	acyl-CoA dehydrogenase activity
B1865_RS03195	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B1865_RS03200	COG1028	Short-chain dehydrogenase reductase Sdr
B1865_RS03215	COG2718	Belongs to the UPF0229 family
B1865_RS03220	COG2719	SpoVR family
B1865_RS03245	COG2188	Transcriptional regulator
B1865_RS03260	COG0633	Ferredoxin
B1865_RS03270	COG0829	nickel cation binding
B1865_RS03275	COG0831	urea catabolic process
B1865_RS03285	COG0832	Belongs to the urease beta subunit family
B1865_RS03290	COG0804	urea catabolic process
B1865_RS03300	COG0830	nickel cation binding
B1865_RS03305	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
B1865_RS03325	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B1865_RS03330	COG0601	transmembrane transport
B1865_RS03335	COG0747	negative chemotaxis
B1865_RS03345	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B1865_RS03350	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B1865_RS03360	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
B1865_RS03370	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
B1865_RS03375	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B1865_RS03380	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
B1865_RS03395	COG0438	transferase activity, transferring glycosyl groups
B1865_RS03410	COG0438	transferase activity, transferring glycosyl groups
B1865_RS03415	COG0438	transferase activity, transferring glycosyl groups
B1865_RS03420	COG0166	Belongs to the GPI family
B1865_RS03435	COG0277	FAD linked oxidase domain protein
B1865_RS03440	COG0745	RESPONSE REGULATOR receiver
B1865_RS03445	COG0642	Histidine kinase
B1865_RS03450	COG1368	sulfuric ester hydrolase activity
B1865_RS03460	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
B1865_RS03485	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
B1865_RS03495	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
B1865_RS03500	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
B1865_RS03510	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
B1865_RS03515	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
B1865_RS03520	COG0193	aminoacyl-tRNA hydrolase activity
B1865_RS03530	COG0012	GTP binding
B1865_RS03535	COG0582	viral genome integration into host DNA
B1865_RS03555	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
B1865_RS03600	COG0745	RESPONSE REGULATOR receiver
B1865_RS03615	COG1309	transcriptional regulator
B1865_RS03640	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B1865_RS03650	COG0405	Gamma-glutamyltransferase
B1865_RS03665	COG1280	lysine exporter protein (LysE YggA)
B1865_RS03725	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
B1865_RS03730	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B1865_RS03740	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
B1865_RS03745	COG0513	Belongs to the DEAD box helicase family
B1865_RS03755	COG0617	tRNA 3'-terminal CCA addition
B1865_RS03770	COG0477	Major facilitator Superfamily
B1865_RS03780	COG0583	DNA-binding transcription factor activity
B1865_RS03795	COG1950	PFAM Membrane protein of
B1865_RS03800	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
B1865_RS03815	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
B1865_RS03825	COG1560	Kdo2-lipid A biosynthetic process
B1865_RS03830	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
B1865_RS03840	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
B1865_RS03850	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
B1865_RS03860	COG0803	Belongs to the bacterial solute-binding protein 9 family
B1865_RS03880	COG0735	belongs to the Fur family
B1865_RS03885	COG0523	cobalamin synthesis protein
B1865_RS03895	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
B1865_RS03900	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
B1865_RS03910	COG2096	Adenosyltransferase
B1865_RS03925	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
B1865_RS03930	COG2084	Dehydrogenase
B1865_RS03975	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
B1865_RS03980	COG0129	dihydroxy-acid dehydratase activity
B1865_RS03985	COG4654	Cytochrome c, class I
B1865_RS03990	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B1865_RS04040	COG1473	amidohydrolase
B1865_RS04045	COG0418	dihydroorotase activity
B1865_RS04050	COG0488	(ABC) transporter
B1865_RS04055	COG2001	Belongs to the MraZ family
B1865_RS04060	COG0275	rRNA processing
B1865_RS04065	COG3116	cell division
B1865_RS04075	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
B1865_RS04080	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B1865_RS04085	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
B1865_RS04095	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B1865_RS04100	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
B1865_RS04105	COG1181	Belongs to the D-alanine--D-alanine ligase family
B1865_RS04110	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
B1865_RS04120	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
B1865_RS04125	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
B1865_RS04135	COG0739	heme binding
B1865_RS04140	COG0653	protein targeting
B1865_RS04160	COG1028	Short-chain dehydrogenase reductase Sdr
B1865_RS04165	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B1865_RS04170	COG1522	sequence-specific DNA binding
B1865_RS04190	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
B1865_RS04200	COG0557	exoribonuclease II activity
B1865_RS04205	COG3150	esterase
B1865_RS04210	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
B1865_RS04215	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B1865_RS04220	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
B1865_RS04225	COG0511	ligase activity, forming carbon-carbon bonds
B1865_RS04230	COG0439	Biotin carboxylase
B1865_RS04235	COG2264	protein methyltransferase activity
B1865_RS04245	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B1865_RS04270	COG1696	Membrane protein involved in D-alanine export
B1865_RS04275	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B1865_RS04310	COG1522	sequence-specific DNA binding
B1865_RS04325	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B1865_RS04330	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B1865_RS04330	COG1042	CoA-binding domain protein
B1865_RS04330	COG0045	succinate-CoA ligase (ADP-forming) activity
B1865_RS04340	COG1802	Transcriptional regulator
B1865_RS04345	COG3069	C4-dicarboxylate transmembrane transporter activity
B1865_RS04350	COG0513	Belongs to the DEAD box helicase family
B1865_RS04355	COG0346	lactoylglutathione lyase activity
B1865_RS04360	COG1335	isochorismatase
B1865_RS04365	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B1865_RS04370	COG1116	anion transmembrane transporter activity
B1865_RS04385	COG3028	Belongs to the UPF0307 family
B1865_RS04390	COG0312	modulator of DNA gyrase
B1865_RS04395	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
B1865_RS04400	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
B1865_RS04405	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
B1865_RS04410	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
B1865_RS04420	COG0316	Belongs to the HesB IscA family
B1865_RS04425	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
B1865_RS04440	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
B1865_RS04450	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
B1865_RS04455	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
B1865_RS04470	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B1865_RS04470	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B1865_RS04500	COG0583	DNA-binding transcription factor activity
B1865_RS04505	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B1865_RS04540	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
B1865_RS04550	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
B1865_RS04555	COG1845	cytochrome c oxidase, subunit III
B1865_RS04560	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
B1865_RS04565	COG0640	Transcriptional regulator
B1865_RS04585	COG3220	belongs to the UPF0276 family
B1865_RS04630	COG1666	GTP binding
B1865_RS04665	COG0312	modulator of DNA gyrase
B1865_RS04670	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
B1865_RS04675	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
B1865_RS04675	COG3210	domain, Protein
B1865_RS04675	COG3064	Membrane
B1865_RS04675	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
B1865_RS04675	COG3210	domain, Protein
B1865_RS04675	COG3064	Membrane
B1865_RS04680	COG0277	FAD linked oxidase domain protein
B1865_RS04685	COG0277	FAD linked oxidase domain protein
B1865_RS04690	COG0277	FAD linked oxidase domain protein
B1865_RS04695	COG0247	lactate metabolic process
B1865_RS04700	COG2819	hydrolase of the alpha beta superfamily
B1865_RS04735	COG0583	DNA-binding transcription factor activity
B1865_RS04740	COG0482	sulfurtransferase activity
B1865_RS04745	COG0730	response to heat
B1865_RS04750	COG0625	glutathione transferase activity
B1865_RS04755	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
B1865_RS04760	COG3909	cytochrome
B1865_RS04800	COG0154	amidase activity
B1865_RS04805	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B1865_RS04810	COG1024	Enoyl-CoA hydratase
B1865_RS04825	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B1865_RS04840	COG1028	Short-chain dehydrogenase reductase Sdr
B1865_RS04845	COG1414	Transcriptional regulator
B1865_RS04855	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B1865_RS04860	COG0251	oxidation-reduction process
B1865_RS04865	COG0559	Belongs to the binding-protein-dependent transport system permease family
B1865_RS04885	COG1902	pentaerythritol trinitrate reductase activity
B1865_RS04900	COG0583	DNA-binding transcription factor activity
B1865_RS04910	COG0590	tRNA wobble adenosine to inosine editing
B1865_RS04915	COG2807	transmembrane transport
B1865_RS04935	COG0154	amidase activity
B1865_RS04940	COG0307	riboflavin synthase, alpha
B1865_RS04945	COG3181	Tripartite tricarboxylate transporter family receptor
B1865_RS04950	COG1522	sequence-specific DNA binding
B1865_RS04960	COG0318	PFAM AMP-dependent synthetase and ligase
B1865_RS04970	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B1865_RS04990	COG1063	alcohol dehydrogenase
B1865_RS05015	COG1418	mRNA catabolic process
B1865_RS05020	COG1448	Aminotransferase
B1865_RS05025	COG0583	DNA-binding transcription factor activity
B1865_RS05035	COG0477	Major facilitator Superfamily
B1865_RS05040	COG1028	Short-chain dehydrogenase reductase Sdr
B1865_RS05055	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
B1865_RS05060	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
B1865_RS05065	COG0583	DNA-binding transcription factor activity
B1865_RS05105	COG1028	Short-chain dehydrogenase reductase Sdr
B1865_RS05110	COG1309	transcriptional regulator
B1865_RS05120	COG2982	Protein involved in outer membrane biogenesis
B1865_RS05125	COG2818	Glycosylase
B1865_RS05145	COG1653	transport
B1865_RS05155	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B1865_RS05160	COG3842	ATPase activity
B1865_RS05165	COG0395	ABC-type sugar transport system, permease component
B1865_RS05170	COG1175	transmembrane transport
B1865_RS05195	COG3181	Tripartite tricarboxylate transporter family receptor
B1865_RS05200	COG2186	Transcriptional regulator
B1865_RS05225	COG1454	alcohol dehydrogenase
B1865_RS05245	COG2011	ABC-type metal ion transport system permease component
B1865_RS05250	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
B1865_RS05255	COG1501	Belongs to the glycosyl hydrolase 31 family
B1865_RS05275	COG0318	PFAM AMP-dependent synthetase and ligase
B1865_RS05280	COG1473	amidohydrolase
B1865_RS05290	COG2855	membrane
B1865_RS05300	COG2239	Acts as a magnesium transporter
B1865_RS05320	COG3181	Tripartite tricarboxylate transporter family receptor
B1865_RS05330	COG1722	exodeoxyribonuclease VII activity
B1865_RS05335	COG0142	geranyltranstransferase activity
B1865_RS05340	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
B1865_RS05345	COG1469	GTP cyclohydrolase I activity
B1865_RS05350	COG0360	Binds together with S18 to 16S ribosomal RNA
B1865_RS05355	COG2965	DNA replication, synthesis of RNA primer
B1865_RS05360	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
B1865_RS05365	COG0359	binds to the 23S rRNA
B1865_RS05375	COG0305	Participates in initiation and elongation during chromosome replication
B1865_RS05385	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
B1865_RS05390	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
B1865_RS05395	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
B1865_RS05400	COG3737	Protein of unknown function (DUF498/DUF598)
B1865_RS05405	COG0436	Aminotransferase
B1865_RS05430	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
B1865_RS05460	COG0268	Binds directly to 16S ribosomal RNA
B1865_RS05470	COG0728	peptidoglycan biosynthetic process
B1865_RS05480	COG0563	adenylate kinase activity
B1865_RS05485	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
B1865_RS05490	COG2835	tetraacyldisaccharide 4'-kinase activity
B1865_RS05495	COG1663	tetraacyldisaccharide 4'-kinase activity
B1865_RS05500	COG0848	biopolymer transport protein
B1865_RS05505	COG0811	peptide transport
B1865_RS05515	COG1570	exodeoxyribonuclease VII activity
B1865_RS05520	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
B1865_RS05525	COG0038	chloride channel
B1865_RS05530	COG0183	Belongs to the thiolase family
B1865_RS05540	COG1278	Cold shock
B1865_RS05545	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
B1865_RS05555	COG4953	penicillin-binding protein 1C
B1865_RS05560	COG0542	response to heat
B1865_RS05565	COG2995	paraquat-inducible protein a
B1865_RS05570	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
B1865_RS05570	COG3008	intermembrane lipid transfer
B1865_RS05580	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
B1865_RS05580	COG0506	proline dehydrogenase activity
B1865_RS05580	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
B1865_RS05615	COG2271	Major facilitator Superfamily
B1865_RS05620	COG1309	transcriptional regulator
B1865_RS05630	COG3468	outer membrane autotransporter barrel domain protein
B1865_RS05660	COG0477	Major facilitator Superfamily
B1865_RS05670	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
B1865_RS05675	COG1845	cytochrome c oxidase, subunit III
B1865_RS05680	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
B1865_RS05690	COG1028	Short-chain dehydrogenase reductase Sdr
B1865_RS05710	COG0789	Transcriptional regulator
B1865_RS05735	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
B1865_RS05740	COG0697	spore germination
B1865_RS05750	COG0678	peroxiredoxin activity
B1865_RS05760	COG0412	Dienelactone hydrolase
B1865_RS05770	COG0315	cyclic pyranopterin monophosphate synthase activity
B1865_RS05785	COG0521	Mo-molybdopterin cofactor biosynthetic process
B1865_RS05790	COG0303	'Molybdopterin
B1865_RS05795	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
B1865_RS05815	COG0165	Argininosuccinate lyase
B1865_RS05820	COG0668	transmembrane transport
B1865_RS05865	COG0747	negative chemotaxis
B1865_RS05870	COG0601	transmembrane transport
B1865_RS05875	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B1865_RS05880	COG1162	GTPase activity
B1865_RS05885	COG0501	Belongs to the peptidase M48B family
B1865_RS05890	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
B1865_RS05900	COG3327	negative regulation of DNA-templated transcription, initiation
B1865_RS05905	COG3396	Phenylacetate-CoA oxygenase
B1865_RS05910	COG3460	Phenylacetate-CoA oxygenase
B1865_RS05915	COG3396	Phenylacetate-CoA oxygenase
B1865_RS05920	COG2151	metal-sulfur cluster biosynthetic enzyme
B1865_RS05925	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
B1865_RS05935	COG1012	belongs to the aldehyde dehydrogenase family
B1865_RS05940	COG1024	Enoyl-CoA hydratase
B1865_RS05945	COG2050	protein possibly involved in aromatic compounds catabolism
B1865_RS05955	COG3539	Fimbrial protein
B1865_RS05970	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
B1865_RS05975	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
B1865_RS05975	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
B1865_RS05980	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
B1865_RS05985	COG0047	phosphoribosylformylglycinamidine synthase activity
B1865_RS05985	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B1865_RS05990	COG3210	domain, Protein
B1865_RS05990	COG3064	Membrane
B1865_RS05990	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
B1865_RS06015	COG0235	Class ii aldolase
B1865_RS06020	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
B1865_RS06025	COG0720	synthase
B1865_RS06030	COG0602	queuosine metabolic process
B1865_RS06055	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B1865_RS06090	COG3181	Tripartite tricarboxylate transporter family receptor
B1865_RS06120	COG3842	ATPase activity
B1865_RS06130	COG0395	ABC-type sugar transport system, permease component
B1865_RS06160	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B1865_RS06165	COG0420	3'-5' exonuclease activity
B1865_RS06190	COG2197	response regulator
B1865_RS06215	COG0518	GMP synthase (glutamine-hydrolyzing) activity
B1865_RS06215	COG0519	Catalyzes the synthesis of GMP from XMP
B1865_RS06225	COG3550	peptidyl-serine autophosphorylation
B1865_RS06235	COG0477	Major facilitator Superfamily
B1865_RS06250	COG1228	amidohydrolase
B1865_RS06260	COG1116	anion transmembrane transporter activity
B1865_RS06265	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B1865_RS06300	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
B1865_RS06315	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
B1865_RS06345	COG2814	Major facilitator Superfamily
B1865_RS06360	COG1280	lysine exporter protein (LysE YggA)
B1865_RS06375	COG0747	negative chemotaxis
B1865_RS06380	COG0601	transmembrane transport
B1865_RS06385	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B1865_RS06390	COG4172	Belongs to the ABC transporter superfamily
B1865_RS06395	COG1609	Transcriptional regulator
B1865_RS06420	COG0586	Pfam SNARE associated Golgi protein
B1865_RS06430	COG0500	methyltransferase
B1865_RS06445	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B1865_RS06455	COG0756	dUTP diphosphatase activity
B1865_RS06465	COG0291	Belongs to the bacterial ribosomal protein bL35 family
B1865_RS06470	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
B1865_RS06475	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
B1865_RS06480	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B1865_RS06480	COG0072	phenylalanine-tRNA ligase activity
B1865_RS06485	COG0776	regulation of translation
B1865_RS06555	COG0540	Belongs to the ATCase OTCase family
B1865_RS06560	COG2974	May be involved in recombination
B1865_RS06570	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B1865_RS06575	COG0583	DNA-binding transcription factor activity
B1865_RS06595	COG1028	Short-chain dehydrogenase reductase Sdr
B1865_RS06610	COG3842	ATPase activity
B1865_RS06615	COG1250	3-hydroxyacyl-CoA dehydrogenase
B1865_RS06615	COG1024	Enoyl-CoA hydratase
B1865_RS06635	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
B1865_RS06640	COG2137	regulation of response to DNA damage stimulus
B1865_RS06650	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
B1865_RS06660	COG0045	succinate-CoA ligase (ADP-forming) activity
B1865_RS06665	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
B1865_RS06670	COG0861	Integral membrane protein TerC family
B1865_RS06675	COG0861	Integral membrane protein TerC family
B1865_RS06680	COG0181	hydroxymethylbilane synthase activity
B1865_RS06740	COG4964	Belongs to the GSP D family
B1865_RS06770	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
B1865_RS06780	COG0583	DNA-binding transcription factor activity
B1865_RS06790	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B1865_RS06795	COG4311	Sarcosine oxidase, delta subunit
B1865_RS06800	COG0404	The glycine cleavage system catalyzes the degradation of glycine
B1865_RS06800	COG0446	pyridine nucleotide-disulphide oxidoreductase
B1865_RS06835	COG0812	UDP-N-acetylmuramate dehydrogenase activity
B1865_RS06840	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
B1865_RS06845	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B1865_RS06850	COG0735	belongs to the Fur family
B1865_RS06855	COG0497	DNA recombination
B1865_RS06860	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
B1865_RS06865	COG1420	regulation of RNA biosynthetic process
B1865_RS06870	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
B1865_RS06880	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
B1865_RS06890	COG0443	Heat shock 70 kDa protein
B1865_RS06900	COG0612	Peptidase, M16
B1865_RS06920	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B1865_RS06965	COG0745	RESPONSE REGULATOR receiver
B1865_RS06970	COG2205	protein histidine kinase activity
B1865_RS06975	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
B1865_RS06980	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
B1865_RS06985	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
B1865_RS06995	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B1865_RS07015	COG1193	negative regulation of DNA recombination
B1865_RS07020	COG0492	ferredoxin-NADP+ reductase activity
B1865_RS07025	COG1674	ftsk spoiiie
B1865_RS07030	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
B1865_RS07035	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
B1865_RS07040	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
B1865_RS07065	COG3706	GGDEF domain
B1865_RS07085	COG2814	Major facilitator Superfamily
B1865_RS07115	COG3486	L-lysine 6-monooxygenase (NADPH) activity
B1865_RS07130	COG1028	Short-chain dehydrogenase reductase Sdr
B1865_RS07140	COG3022	response to hydroperoxide
B1865_RS07150	COG1289	transmembrane transporter activity
B1865_RS07170	COG0635	Involved in the biosynthesis of porphyrin-containing compound
B1865_RS07180	COG2197	response regulator
B1865_RS07185	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
B1865_RS07190	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
B1865_RS07195	COG0189	ligase activity
B1865_RS07205	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
B1865_RS07210	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B1865_RS07220	COG2423	ornithine cyclodeaminase activity
B1865_RS07230	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B1865_RS07235	COG0765	amino acid transport
B1865_RS07240	COG0765	amino acid transport
B1865_RS07245	COG1126	abc transporter atp-binding protein
B1865_RS07300	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
B1865_RS07310	COG2944	sequence-specific DNA binding
B1865_RS07315	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
B1865_RS07320	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
B1865_RS07325	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
B1865_RS07330	COG0009	L-threonylcarbamoyladenylate synthase
B1865_RS07335	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B1865_RS07340	COG1414	Transcriptional regulator
B1865_RS07355	COG0765	amino acid transport
B1865_RS07360	COG1126	abc transporter atp-binding protein
B1865_RS07365	COG0028	Belongs to the TPP enzyme family
B1865_RS07380	COG0028	Belongs to the TPP enzyme family
B1865_RS07385	COG0583	DNA-binding transcription factor activity
B1865_RS07390	COG4974	Belongs to the 'phage' integrase family
B1865_RS07395	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
B1865_RS07400	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
B1865_RS07415	COG1686	Belongs to the peptidase S11 family
B1865_RS07425	COG2814	Major facilitator Superfamily
B1865_RS07435	COG1074	ATP-dependent DNA helicase activity
B1865_RS07440	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
B1865_RS07445	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
B1865_RS07450	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
B1865_RS07470	COG2321	neutral zinc metallopeptidase
B1865_RS07475	COG0009	L-threonylcarbamoyladenylate synthase
B1865_RS07515	COG3360	Dodecin
B1865_RS07520	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
B1865_RS07525	COG2850	peptidyl-arginine hydroxylation
B1865_RS07530	COG3539	Fimbrial protein
B1865_RS07535	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
B1865_RS07540	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B1865_RS07545	COG1994	Peptidase M50
B1865_RS07555	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B1865_RS07560	COG0765	amino acid transport
B1865_RS07565	COG1126	abc transporter atp-binding protein
B1865_RS07570	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B1865_RS07575	COG1758	RNA polymerase activity
B1865_RS07580	COG0194	GDP metabolic process
B1865_RS07585	COG3258	Cytochrome c
B1865_RS07590	COG2863	cytochrome
B1865_RS07595	COG1028	Short-chain dehydrogenase reductase Sdr
B1865_RS07600	COG0791	NLP P60 protein
B1865_RS07605	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
B1865_RS07625	COG1561	YicC-like family, N-terminal region
B1865_RS07630	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
B1865_RS07645	COG2200	EAL domain
B1865_RS07645	COG2199	diguanylate cyclase activity
B1865_RS07650	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
B1865_RS07660	COG0635	Involved in the biosynthesis of porphyrin-containing compound
B1865_RS07665	COG0174	glutamine synthetase
B1865_RS07675	COG2204	response regulator
B1865_RS07680	COG0583	DNA-binding transcription factor activity
B1865_RS07685	COG1741	Belongs to the pirin family
B1865_RS07690	COG1741	Belongs to the pirin family
B1865_RS07700	COG3842	ATPase activity
B1865_RS07705	COG1178	ABC-type Fe3 transport system permease component
B1865_RS07710	COG1840	ABC-type Fe3 transport system, periplasmic component
B1865_RS07720	COG0583	DNA-binding transcription factor activity
B1865_RS07730	COG0656	L-ascorbic acid biosynthetic process
B1865_RS07745	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
B1865_RS07750	COG0583	DNA-binding transcription factor activity
B1865_RS07765	COG0783	Belongs to the Dps family
B1865_RS07800	COG0438	transferase activity, transferring glycosyl groups
B1865_RS07815	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
B1865_RS07840	COG0300	oxidoreductase activity
B1865_RS07885	COG0861	Integral membrane protein TerC family
B1865_RS07890	COG1028	Short-chain dehydrogenase reductase Sdr
B1865_RS07910	COG0714	Associated with various cellular activities
B1865_RS07940	COG3119	arylsulfatase activity
B1865_RS07965	COG2197	response regulator
B1865_RS07975	COG2944	sequence-specific DNA binding
B1865_RS07980	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
B1865_RS07985	COG0625	glutathione transferase activity
B1865_RS08015	COG0179	Fumarylacetoacetate (FAA) hydrolase
B1865_RS08020	COG1028	Short-chain dehydrogenase reductase Sdr
B1865_RS08065	COG0431	NADPH-dependent FMN reductase
B1865_RS08095	COG1028	Short-chain dehydrogenase reductase Sdr
B1865_RS08100	COG0583	DNA-binding transcription factor activity
B1865_RS08115	COG3181	Tripartite tricarboxylate transporter family receptor
B1865_RS08120	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
B1865_RS08120	COG2111	Na H antiporter
B1865_RS08125	COG1006	Multisubunit Na H antiporter MnhC subunit
B1865_RS08130	COG0651	ATP synthesis coupled electron transport
B1865_RS08135	COG1863	multisubunit Na H antiporter MnhE subunit
B1865_RS08140	COG2212	antiporter activity
B1865_RS08165	COG0590	tRNA wobble adenosine to inosine editing
B1865_RS08170	COG1619	proteins homologs of microcin C7 resistance protein MccF
B1865_RS08175	COG1024	Enoyl-CoA hydratase
B1865_RS08190	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
B1865_RS08195	COG0488	(ABC) transporter
B1865_RS08230	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
B1865_RS08230	COG1017	nitric oxide dioxygenase activity
B1865_RS08235	COG1959	2 iron, 2 sulfur cluster binding
B1865_RS08240	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B1865_RS08260	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
B1865_RS08265	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
B1865_RS08270	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
B1865_RS08275	COG0084	hydrolase, TatD family'
B1865_RS08290	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B1865_RS08300	COG1126	abc transporter atp-binding protein
B1865_RS08305	COG0010	Belongs to the arginase family
B1865_RS08310	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
B1865_RS08315	COG1012	belongs to the aldehyde dehydrogenase family
B1865_RS08325	COG0028	Belongs to the TPP enzyme family
B1865_RS08335	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
B1865_RS08335	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
B1865_RS08345	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
B1865_RS08360	COG3189	MarR family transcriptional regulator
B1865_RS08385	COG4336	lyase activity
B1865_RS08395	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B1865_RS08395	COG2205	protein histidine kinase activity
B1865_RS08400	COG2197	response regulator
B1865_RS08405	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
B1865_RS08405	COG3210	domain, Protein
B1865_RS08405	COG3064	Membrane
B1865_RS08415	COG3121	Chaperone
B1865_RS08420	COG3188	usher protein
B1865_RS08425	COG3539	Fimbrial protein
B1865_RS08430	COG2831	hemolysin activation secretion protein
B1865_RS08445	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
B1865_RS08470	COG0583	DNA-binding transcription factor activity
B1865_RS08495	COG0668	transmembrane transport
B1865_RS08515	COG0483	inositol monophosphate 1-phosphatase activity
B1865_RS08520	COG1253	flavin adenine dinucleotide binding
B1865_RS08525	COG1968	undecaprenyl-diphosphatase activity
B1865_RS08530	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B1865_RS08545	COG0215	cysteine-tRNA ligase activity
B1865_RS08555	COG0825	malonyl-CoA metabolic process
B1865_RS08565	COG0037	tRNA processing
B1865_RS08570	COG0527	aspartate kinase activity
B1865_RS08595	COG1250	3-hydroxyacyl-CoA dehydrogenase
B1865_RS08600	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
B1865_RS08600	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
B1865_RS08615	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
B1865_RS08620	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
B1865_RS08625	COG1028	Short-chain dehydrogenase reductase Sdr
B1865_RS08635	COG0583	DNA-binding transcription factor activity
B1865_RS08665	COG3842	ATPase activity
B1865_RS08675	COG0446	pyridine nucleotide-disulphide oxidoreductase
B1865_RS08675	COG1902	pentaerythritol trinitrate reductase activity
B1865_RS08680	COG1414	Transcriptional regulator
B1865_RS08685	COG1832	CoA-binding protein
B1865_RS08695	COG0251	oxidation-reduction process
B1865_RS08720	COG1902	pentaerythritol trinitrate reductase activity
B1865_RS08730	COG1215	transferase activity, transferring glycosyl groups
B1865_RS08735	COG0726	polysaccharide deacetylase
B1865_RS08735	COG1649	PFAM Uncharacterised BCR, COG1649
B1865_RS08755	COG1846	Transcriptional regulator
B1865_RS08775	COG0166	Belongs to the GPI family
B1865_RS08780	COG1045	serine acetyltransferase
B1865_RS08790	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
B1865_RS08795	COG0483	inositol monophosphate 1-phosphatase activity
B1865_RS08800	COG1012	belongs to the aldehyde dehydrogenase family
B1865_RS08805	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
B1865_RS08820	COG0210	DNA helicase
B1865_RS08825	COG0598	Magnesium transport protein CorA
B1865_RS08835	COG0747	negative chemotaxis
B1865_RS08840	COG0601	transmembrane transport
B1865_RS08845	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B1865_RS08850	COG4172	Belongs to the ABC transporter superfamily
B1865_RS08855	COG1846	Transcriptional regulator
B1865_RS08905	COG4964	Belongs to the GSP D family
B1865_RS08945	COG2204	response regulator
B1865_RS08960	COG1595	DNA-templated transcription, initiation
B1865_RS08970	COG3474	cytochrome
B1865_RS08975	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
B1865_RS08990	COG3384	dioxygenase
B1865_RS08995	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
B1865_RS09020	COG2885	chlorophyll binding
B1865_RS09055	COG0697	spore germination
B1865_RS09060	COG0730	response to heat
B1865_RS09075	COG0583	DNA-binding transcription factor activity
B1865_RS09080	COG0427	acetyl-CoA hydrolase
B1865_RS09135	COG1250	3-hydroxyacyl-CoA dehydrogenase
B1865_RS09140	COG0154	amidase activity
B1865_RS09150	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
B1865_RS09165	COG0495	leucyl-tRNA aminoacylation
B1865_RS09170	COG2814	Major facilitator Superfamily
B1865_RS09200	COG0267	Belongs to the bacterial ribosomal protein bL33 family
B1865_RS09205	COG0227	Belongs to the bacterial ribosomal protein bL28 family
B1865_RS09210	COG2814	Major facilitator Superfamily
B1865_RS09215	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
B1865_RS09230	COG4176	ABC-type proline glycine betaine transport system permease component
B1865_RS09240	COG1942	4-Oxalocrotonate Tautomerase
B1865_RS09245	COG0183	Belongs to the thiolase family
B1865_RS09255	COG1802	Transcriptional regulator
B1865_RS09265	COG1024	Enoyl-CoA hydratase
B1865_RS09280	COG2032	superoxide dismutase activity
B1865_RS09295	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
B1865_RS09320	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B1865_RS09325	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B1865_RS09335	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
B1865_RS09340	COG0736	holo-[acyl-carrier-protein] synthase activity
B1865_RS09345	COG1472	Belongs to the glycosyl hydrolase 3 family
B1865_RS09350	COG0322	excinuclease ABC activity
B1865_RS09355	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
B1865_RS09370	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
B1865_RS09370	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
B1865_RS09375	COG2224	Isocitrate lyase
B1865_RS09395	COG0559	Belongs to the binding-protein-dependent transport system permease family
B1865_RS09405	COG4638	Rieske (2fe-2S)
B1865_RS09415	COG1024	Enoyl-CoA hydratase
B1865_RS09425	COG0633	Ferredoxin
B1865_RS09430	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B1865_RS09445	COG0183	Belongs to the thiolase family
B1865_RS09455	COG4692	amylo-alpha-1,6-glucosidase activity
B1865_RS09460	COG0583	DNA-binding transcription factor activity
B1865_RS09485	COG2346	COG2346, Truncated hemoglobins
B1865_RS09610	COG2207	Transcriptional regulator
B1865_RS09655	COG1132	(ABC) transporter
B1865_RS09680	COG0659	secondary active sulfate transmembrane transporter activity
B1865_RS09710	COG2169	Transcriptional regulator
B1865_RS09715	COG5507	3-demethylubiquinone-9 3-methyltransferase
B1865_RS09720	COG0384	phenazine biosynthesis protein PhzF
B1865_RS09725	COG0583	DNA-binding transcription factor activity
B1865_RS09730	COG2733	membrane
B1865_RS09745	COG1012	belongs to the aldehyde dehydrogenase family
B1865_RS09750	COG3284	Transcriptional regulator
B1865_RS09765	COG1346	cytolysis
B1865_RS09770	COG1380	Effector of murein hydrolase LrgA
B1865_RS09775	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
B1865_RS09775	COG4106	trans-aconitate 2-methyltransferase activity
B1865_RS09785	COG0156	8-amino-7-oxononanoate synthase activity
B1865_RS09855	COG1131	(ABC) transporter
B1865_RS09860	COG0842	Transport permease protein
B1865_RS09865	COG0628	permease
B1865_RS09895	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
B1865_RS09905	COG0828	Belongs to the bacterial ribosomal protein bS21 family
B1865_RS09910	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
B1865_RS09915	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
B1865_RS09920	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
B1865_RS09925	COG0330	HflC and HflK could
B1865_RS09930	COG0330	HflC and HflK could
B1865_RS09935	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
B1865_RS09940	COG1923	regulation of RNA biosynthetic process
B1865_RS09945	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B1865_RS09950	COG1160	GTP binding
B1865_RS09955	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B1865_RS09960	COG2976	Protein conserved in bacteria
B1865_RS09965	COG0124	histidyl-tRNA synthetase
B1865_RS09970	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
B1865_RS09980	COG0820	rRNA (adenine-C2-)-methyltransferase activity
B1865_RS09985	COG0105	UTP biosynthetic process
B1865_RS09990	COG0525	valine-tRNA ligase activity
B1865_RS10005	COG0642	Histidine kinase
B1865_RS10025	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
B1865_RS10030	COG0336	Belongs to the RNA methyltransferase TrmD family
B1865_RS10035	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
B1865_RS10040	COG0228	four-way junction DNA binding
B1865_RS10050	COG0425	Belongs to the sulfur carrier protein TusA family
B1865_RS10055	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
B1865_RS10100	COG0154	amidase activity
B1865_RS10105	COG4172	Belongs to the ABC transporter superfamily
B1865_RS10110	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B1865_RS10115	COG0601	transmembrane transport
B1865_RS10120	COG0747	negative chemotaxis
B1865_RS10145	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B1865_RS10155	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
B1865_RS10170	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
B1865_RS10175	COG3395	kinase activity
B1865_RS10190	COG1024	Enoyl-CoA hydratase
B1865_RS10210	COG0633	Ferredoxin
B1865_RS10215	COG0443	Heat shock 70 kDa protein
B1865_RS10220	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
B1865_RS10225	COG0316	Belongs to the HesB IscA family
B1865_RS10230	COG0822	iron-sulfur transferase activity
B1865_RS10235	COG1104	cysteine desulfurase activity
B1865_RS10245	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B1865_RS10250	COG0556	nucleotide-excision repair
B1865_RS10260	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
B1865_RS10265	COG3468	outer membrane autotransporter barrel domain protein
B1865_RS10290	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
B1865_RS10305	COG1960	acyl-CoA dehydrogenase activity
B1865_RS10310	COG1028	Short-chain dehydrogenase reductase Sdr
B1865_RS10315	COG0183	Belongs to the thiolase family
B1865_RS10325	COG1024	Enoyl-CoA hydratase
B1865_RS10340	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B1865_RS10345	COG0583	DNA-binding transcription factor activity
B1865_RS10350	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
B1865_RS10355	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
B1865_RS10360	COG0740	serine-type endopeptidase activity
B1865_RS10365	COG0544	peptidyl-prolyl cis-trans isomerase activity
B1865_RS10375	COG1278	Cold shock
B1865_RS10385	COG1278	Cold shock
B1865_RS10420	COG2171	N-acyltransferase activity
B1865_RS10425	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B1865_RS10430	COG2890	protein-(glutamine-N5) methyltransferase activity
B1865_RS10435	COG0488	(ABC) transporter
B1865_RS10440	COG4771	TonB-dependent receptor
B1865_RS10445	COG0210	DNA helicase
B1865_RS10465	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
B1865_RS10465	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B1865_RS10470	COG0196	riboflavin kinase activity
B1865_RS10475	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
B1865_RS10480	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
B1865_RS10485	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
B1865_RS10495	COG1522	sequence-specific DNA binding
B1865_RS10510	COG2951	lytic endotransglycosylase activity
B1865_RS10515	COG2833	Protein of unknown function (DUF455)
B1865_RS10535	COG0189	ligase activity
B1865_RS10535	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
B1865_RS10540	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
B1865_RS10540	COG1181	Belongs to the D-alanine--D-alanine ligase family
B1865_RS10545	COG3237	CsbD-like
B1865_RS10555	COG2823	Periplasmic or secreted lipoprotein
B1865_RS10570	COG4181	ATPase activity
B1865_RS10580	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B1865_RS10585	COG0584	glycerophosphoryl diester phosphodiesterase
B1865_RS10590	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
B1865_RS10600	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
B1865_RS10600	COG0678	peroxiredoxin activity
B1865_RS10610	COG0789	Transcriptional regulator
B1865_RS10615	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B1865_RS10645	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
B1865_RS10650	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
B1865_RS10660	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
B1865_RS10665	COG2252	PERMEase
B1865_RS10675	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B1865_RS10705	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B1865_RS10710	COG2358	TRAP transporter, solute receptor (TAXI family
B1865_RS10740	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B1865_RS10745	COG1366	Belongs to the anti-sigma-factor antagonist family
B1865_RS10750	COG2172	sigma factor antagonist activity
B1865_RS10755	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
B1865_RS10765	COG2208	phosphoserine phosphatase activity
B1865_RS10765	COG2770	Histidine kinase
B1865_RS10790	COG1595	DNA-templated transcription, initiation
B1865_RS10805	COG4792	protein secretion
B1865_RS10810	COG4791	protein targeting
B1865_RS10815	COG4794	Type iii secretion
B1865_RS10820	COG4790	Type iii secretion
B1865_RS10855	COG4669	(LipO)protein
B1865_RS10920	COG4789	Type iii secretion
B1865_RS10950	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B1865_RS10955	COG0840	transmembrane signaling receptor activity
B1865_RS10960	COG2233	PERMEase
B1865_RS10980	COG0492	ferredoxin-NADP+ reductase activity
B1865_RS10985	COG1840	ABC-type Fe3 transport system, periplasmic component
B1865_RS10990	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B1865_RS10995	COG1178	ABC-type Fe3 transport system permease component
B1865_RS11000	COG3842	ATPase activity
B1865_RS11005	COG0583	DNA-binding transcription factor activity
B1865_RS11025	COG0501	Belongs to the peptidase M48B family
B1865_RS11035	COG0697	spore germination
B1865_RS11045	COG1846	Transcriptional regulator
B1865_RS11055	COG1566	PFAM secretion protein HlyD family protein
B1865_RS11060	COG2814	Major facilitator Superfamily
B1865_RS11065	COG0473	3-isopropylmalate dehydrogenase activity
B1865_RS11075	COG0747	negative chemotaxis
B1865_RS11085	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B1865_RS11100	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
B1865_RS11125	COG1012	belongs to the aldehyde dehydrogenase family
B1865_RS11135	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B1865_RS11140	COG1115	amino acid carrier protein
B1865_RS11145	COG0433	COG0433 Predicted ATPase
B1865_RS11150	COG0217	transcriptional regulatory protein
B1865_RS11155	COG0151	Belongs to the GarS family
B1865_RS11160	COG0408	coproporphyrinogen oxidase activity
B1865_RS11165	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
B1865_RS11170	COG0799	negative regulation of ribosome biogenesis
B1865_RS11175	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
B1865_RS11180	COG0424	maF-like protein
B1865_RS11185	COG3468	outer membrane autotransporter barrel domain protein
B1865_RS11225	COG1530	ribonuclease E activity
B1865_RS11230	COG0077	Prephenate dehydratase
B1865_RS11245	COG1132	(ABC) transporter
B1865_RS11250	COG0859	PFAM glycosyl transferase family 9
B1865_RS11275	COG2194	sulfuric ester hydrolase activity
B1865_RS11280	COG0438	transferase activity, transferring glycosyl groups
B1865_RS11285	COG0463	Glycosyl transferase, family 2
B1865_RS11290	COG0726	polysaccharide deacetylase
B1865_RS11295	COG0438	transferase activity, transferring glycosyl groups
B1865_RS11310	COG1643	Atp-dependent helicase
B1865_RS11315	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
B1865_RS11315	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
B1865_RS11320	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
B1865_RS11330	COG0704	Plays a role in the regulation of phosphate uptake
B1865_RS11335	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
B1865_RS11340	COG1960	acyl-CoA dehydrogenase activity
B1865_RS11365	COG1177	transmembrane transport
B1865_RS11370	COG1176	ABC-type spermidine putrescine transport system, permease component I
B1865_RS11375	COG3842	ATPase activity
B1865_RS11380	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
B1865_RS11395	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
B1865_RS11400	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
B1865_RS11410	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
B1865_RS11410	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
B1865_RS11430	COG0372	Belongs to the citrate synthase family
B1865_RS11435	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
B1865_RS11440	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
B1865_RS11445	COG1053	succinate dehydrogenase
B1865_RS11450	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
B1865_RS11455	COG2009	succinate dehydrogenase
B1865_RS11460	COG2188	Transcriptional regulator
B1865_RS11465	COG0039	L-malate dehydrogenase activity
B1865_RS11495	COG1981	membrane
B1865_RS11520	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B1865_RS11530	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
B1865_RS11560	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
B1865_RS11565	COG0148	phosphopyruvate hydratase activity
B1865_RS11575	COG2877	3-deoxy-8-phosphooctulonate synthase activity
B1865_RS11580	COG0504	CTP synthase activity
B1865_RS11605	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B1865_RS11615	COG0747	negative chemotaxis
B1865_RS11620	COG4172	Belongs to the ABC transporter superfamily
B1865_RS11625	COG1446	asparaginase
B1865_RS11655	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
B1865_RS11670	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
B1865_RS11675	COG0697	spore germination
B1865_RS11680	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B1865_RS11690	COG3193	protein, possibly involved in utilization of glycolate and propanediol
B1865_RS11695	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B1865_RS11700	COG0791	NLP P60 protein
B1865_RS11715	COG0583	DNA-binding transcription factor activity
B1865_RS11730	COG0583	DNA-binding transcription factor activity
B1865_RS11740	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
B1865_RS11755	COG0670	Belongs to the BI1 family
B1865_RS11760	COG3181	Tripartite tricarboxylate transporter family receptor
B1865_RS11775	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
B1865_RS11785	COG1381	Involved in DNA repair and RecF pathway recombination
B1865_RS11790	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
B1865_RS11795	COG0571	ribonuclease III activity
B1865_RS11800	COG0681	Belongs to the peptidase S26 family
B1865_RS11805	COG0481	GTPase activity
B1865_RS11810	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B1865_RS11835	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B1865_RS11840	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B1865_RS11855	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B1865_RS11860	COG0416	fatty acid biosynthetic process
B1865_RS11865	COG0333	Belongs to the bacterial ribosomal protein bL32 family
B1865_RS11870	COG1399	metal-binding, possibly nucleic acid-binding protein
B1865_RS11875	COG0424	maF-like protein
B1865_RS11885	COG3023	N-Acetylmuramoyl-L-alanine amidase
B1865_RS11890	COG1289	transmembrane transporter activity
B1865_RS11900	COG3022	response to hydroperoxide
B1865_RS11915	COG0135	phosphoribosylanthranilate isomerase activity
B1865_RS11930	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
B1865_RS11935	COG0101	tRNA pseudouridine synthase activity
B1865_RS11945	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
B1865_RS11950	COG0473	3-isopropylmalate dehydrogenase activity
B1865_RS11955	COG0066	3-isopropylmalate dehydratase activity
B1865_RS11960	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
B1865_RS11970	COG1122	ATPase activity
B1865_RS12000	COG0437	4 iron, 4 sulfur cluster binding
B1865_RS12005	COG3383	formate dehydrogenase (NAD+) activity
B1865_RS12005	COG0243	molybdopterin cofactor binding
B1865_RS12035	COG0489	protein tyrosine kinase activity
B1865_RS12040	COG0746	molybdenum cofactor guanylyltransferase activity
B1865_RS12045	COG0303	'Molybdopterin
B1865_RS12050	COG1763	Mo-molybdopterin cofactor biosynthetic process
B1865_RS12060	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
B1865_RS12065	COG5001	Diguanylate cyclase
B1865_RS12085	COG3842	ATPase activity
B1865_RS12095	COG0406	alpha-ribazole phosphatase activity
B1865_RS12105	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B1865_RS12110	COG0505	Belongs to the CarA family
B1865_RS12115	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
B1865_RS12145	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
B1865_RS12150	COG1960	acyl-CoA dehydrogenase activity
B1865_RS12160	COG2867	negative regulation of translational initiation
B1865_RS12170	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
B1865_RS12175	COG3706	GGDEF domain
B1865_RS12180	COG0330	HflC and HflK could
B1865_RS12195	COG0519	Catalyzes the synthesis of GMP from XMP
B1865_RS12195	COG0518	GMP synthase (glutamine-hydrolyzing) activity
B1865_RS12205	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
B1865_RS12210	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B1865_RS12215	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
B1865_RS12220	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B1865_RS12230	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
B1865_RS12235	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B1865_RS12240	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
B1865_RS12245	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B1865_RS12250	COG0750	zinc metalloprotease
B1865_RS12255	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
B1865_RS12265	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
B1865_RS12270	COG0233	cytoplasmic translational termination
B1865_RS12275	COG0528	UMP kinase activity
B1865_RS12280	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
B1865_RS12285	COG0052	Belongs to the universal ribosomal protein uS2 family
B1865_RS12290	COG0024	Methionine aminopeptidase
B1865_RS12295	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
B1865_RS12325	COG0285	dihydrofolate synthase activity
B1865_RS12360	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
B1865_RS12370	COG1677	Flagellar hook-basal body complex protein FliE
B1865_RS12380	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
B1865_RS12390	COG1157	protein secretion by the type III secretion system
B1865_RS12415	COG1580	Controls the rotational direction of flagella during chemotaxis
B1865_RS12435	COG1338	Plays a role in the flagellum-specific transport system
B1865_RS12455	COG0840	transmembrane signaling receptor activity
B1865_RS12460	COG0840	transmembrane signaling receptor activity
B1865_RS12465	COG0840	transmembrane signaling receptor activity
B1865_RS12475	COG1256	bacterial-type flagellum assembly
B1865_RS12485	COG1706	bacterial-type flagellum-dependent cell motility
B1865_RS12490	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
B1865_RS12505	COG1749	Flagellar hook protein flgE
B1865_RS12515	COG1558	bacterial-type flagellum-dependent cell motility
B1865_RS12520	COG1815	bacterial-type flagellum-dependent cell motility
B1865_RS12560	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B1865_RS12565	COG0765	amino acid transport
B1865_RS12570	COG1126	abc transporter atp-binding protein
B1865_RS12585	COG4948	Mandelate Racemase Muconate Lactonizing
B1865_RS12590	COG3181	Tripartite tricarboxylate transporter family receptor
B1865_RS12600	COG0066	3-isopropylmalate dehydratase activity
B1865_RS12615	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B1865_RS12625	COG3181	Tripartite tricarboxylate transporter family receptor
B1865_RS12635	COG1802	Transcriptional regulator
B1865_RS12650	COG0583	DNA-binding transcription factor activity
B1865_RS12670	COG1695	Transcriptional regulator
B1865_RS12675	COG3568	Endonuclease Exonuclease Phosphatase
B1865_RS12680	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B1865_RS12695	COG0392	lysyltransferase activity
B1865_RS12735	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
B1865_RS12745	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
B1865_RS12755	COG1640	4-alpha-glucanotransferase
B1865_RS12770	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
B1865_RS12800	COG0667	Aldo Keto reductase
B1865_RS12815	COG2259	Doxx family
B1865_RS12845	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B1865_RS12865	COG0386	Belongs to the glutathione peroxidase family
B1865_RS12870	COG0625	glutathione transferase activity
B1865_RS12885	COG0095	Lipoate-protein ligase
B1865_RS12900	COG0688	phosphatidylethanolamine metabolic process
B1865_RS12910	COG1464	Belongs to the NlpA lipoprotein family
B1865_RS12925	COG2363	Small membrane protein
B1865_RS12950	COG3842	ATPase activity
B1865_RS12955	COG0395	ABC-type sugar transport system, permease component
B1865_RS12960	COG1175	transmembrane transport
B1865_RS12965	COG1653	transport
B1865_RS12975	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
B1865_RS12990	COG0559	Belongs to the binding-protein-dependent transport system permease family
B1865_RS13010	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
B1865_RS13025	COG0697	spore germination
B1865_RS13035	COG2311	Membrane
B1865_RS13060	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
B1865_RS13070	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
B1865_RS13075	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
B1865_RS13080	COG1760	l-serine dehydratase
B1865_RS13085	COG1283	sodium-dependent phosphate transmembrane transporter activity
B1865_RS13090	COG0412	Dienelactone hydrolase
B1865_RS13105	COG1611	Belongs to the LOG family
B1865_RS13125	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
B1865_RS13130	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
B1865_RS13135	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
B1865_RS13140	COG0195	Participates in both transcription termination and antitermination
B1865_RS13140	COG2251	uridine kinase activity
B1865_RS13145	COG0779	Required for maturation of 30S ribosomal subunits
B1865_RS13150	COG1187	pseudouridine synthase activity
B1865_RS13155	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
B1865_RS13165	COG0583	DNA-binding transcription factor activity
B1865_RS13175	COG0523	cobalamin synthesis protein
B1865_RS13195	COG0625	glutathione transferase activity
B1865_RS13200	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
B1865_RS13205	COG1047	Peptidyl-prolyl cis-trans
B1865_RS13210	COG2003	Belongs to the UPF0758 family
B1865_RS13215	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
B1865_RS13220	COG3483	tryptophan 2,3-dioxygenase activity
B1865_RS13225	COG0254	rRNA binding
B1865_RS13235	COG0534	Mate efflux family protein
B1865_RS13255	COG2304	oxidoreductase activity
B1865_RS13275	COG1028	Short-chain dehydrogenase reductase Sdr
B1865_RS13280	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
B1865_RS13285	COG1562	ergosterol biosynthetic process
B1865_RS13290	COG1562	ergosterol biosynthetic process
B1865_RS13295	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
B1865_RS13295	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
B1865_RS13300	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
B1865_RS13310	COG0842	Transport permease protein
B1865_RS13315	COG1131	(ABC) transporter
B1865_RS13335	COG1477	protein flavinylation
B1865_RS13350	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
B1865_RS13365	COG5564	TIM-barrel signal transduction protein
B1865_RS13370	COG5441	Belongs to the UPF0261 family
B1865_RS13380	COG3468	outer membrane autotransporter barrel domain protein
B1865_RS13385	COG3468	outer membrane autotransporter barrel domain protein
B1865_RS13395	COG0542	response to heat
B1865_RS13400	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B1865_RS13415	COG0494	nUDIX hydrolase
B1865_RS13420	COG3530	Putative quorum-sensing-regulated virulence factor
B1865_RS13430	COG1595	DNA-templated transcription, initiation
B1865_RS13435	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B1865_RS13470	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B1865_RS13475	COG0765	amino acid transport
B1865_RS13480	COG0765	amino acid transport
B1865_RS13510	COG2988	succinylglutamate desuccinylase activity
B1865_RS13535	COG3181	Tripartite tricarboxylate transporter family receptor
B1865_RS13540	COG2084	Dehydrogenase
B1865_RS13555	COG1619	proteins homologs of microcin C7 resistance protein MccF
B1865_RS13570	COG2814	Major facilitator Superfamily
B1865_RS13580	COG0583	DNA-binding transcription factor activity
B1865_RS13620	COG0672	)-iron permease
B1865_RS13635	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
B1865_RS13640	COG1028	Short-chain dehydrogenase reductase Sdr
B1865_RS13645	COG3243	poly(R)-hydroxyalkanoic acid synthase
B1865_RS13655	COG0564	pseudouridine synthase activity
B1865_RS13665	COG1199	ATP-dependent helicase activity
B1865_RS13670	COG2183	response to ionizing radiation
B1865_RS13675	COG0180	Tryptophanyl-tRNA synthetase
B1865_RS13695	COG3181	Tripartite tricarboxylate transporter family receptor
B1865_RS13705	COG0583	DNA-binding transcription factor activity
B1865_RS13710	COG1028	Short-chain dehydrogenase reductase Sdr
B1865_RS13715	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
B1865_RS13720	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B1865_RS13725	COG0508	dehydrogenase complex catalyzes the overall conversion of
B1865_RS13730	COG0567	Dehydrogenase, E1 component
B1865_RS13735	COG1297	OPT oligopeptide transporter protein
B1865_RS13740	COG1297	OPT oligopeptide transporter protein
B1865_RS13745	COG1522	sequence-specific DNA binding
B1865_RS13755	COG0281	malic enzyme
B1865_RS13755	COG0280	phosphate acetyltransferase
B1865_RS13760	COG3539	Fimbrial protein
B1865_RS13775	COG0613	PHP domain protein
B1865_RS13810	COG0084	hydrolase, TatD family'
B1865_RS13815	COG1136	(ABC) transporter
B1865_RS13830	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
B1865_RS13835	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
B1865_RS13840	COG1028	Short-chain dehydrogenase reductase Sdr
B1865_RS13845	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
B1865_RS13860	COG1022	Amp-dependent synthetase and ligase
B1865_RS13895	COG2205	protein histidine kinase activity
B1865_RS13900	COG0745	RESPONSE REGULATOR receiver
B1865_RS13905	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
B1865_RS13915	COG1295	ribonuclease BN
B1865_RS13930	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B1865_RS13955	COG1534	Rna-binding protein
B1865_RS13960	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
B1865_RS13965	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B1865_RS13975	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B1865_RS13985	COG0248	Ppx GppA phosphatase
B1865_RS14010	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
B1865_RS14030	COG2732	(Barnase) inhibitor
B1865_RS14040	COG0280	phosphate acetyltransferase
B1865_RS14040	COG0281	malic enzyme
B1865_RS14050	COG0436	Aminotransferase
B1865_RS14055	COG0741	lytic transglycosylase activity
B1865_RS14060	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
B1865_RS14085	COG1648	precorrin-2 dehydrogenase activity
B1865_RS14085	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
B1865_RS14090	COG3468	outer membrane autotransporter barrel domain protein
B1865_RS14100	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
B1865_RS14105	COG2027	D-alanyl-D-alanine carboxypeptidase
B1865_RS14110	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
B1865_RS14115	COG0343	queuine tRNA-ribosyltransferase activity
B1865_RS14120	COG1862	Preprotein translocase
B1865_RS14125	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B1865_RS14130	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B1865_RS14145	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B1865_RS14150	COG1702	phosphate starvation-inducible protein PhoH
B1865_RS14155	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
B1865_RS14160	COG4535	Mg2 and Co2 transporter CorC
B1865_RS14170	COG0667	Aldo Keto reductase
B1865_RS14195	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
B1865_RS14200	COG0745	RESPONSE REGULATOR receiver
B1865_RS14205	COG2201	protein-glutamate methylesterase activity
B1865_RS14215	COG0840	transmembrane signaling receptor activity
B1865_RS14230	COG0745	RESPONSE REGULATOR receiver
B1865_RS14265	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
B1865_RS14275	COG0739	heme binding
B1865_RS14285	COG0521	Mo-molybdopterin cofactor biosynthetic process
B1865_RS14295	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
B1865_RS14325	COG0625	glutathione transferase activity
B1865_RS14340	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
B1865_RS14345	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
B1865_RS14350	COG0126	phosphoglycerate kinase activity
B1865_RS14355	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
B1865_RS14360	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
B1865_RS14365	COG1385	rRNA (uridine-N3-)-methyltransferase activity
B1865_RS14375	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
B1865_RS14380	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B1865_RS14385	COG0508	dehydrogenase complex catalyzes the overall conversion of
B1865_RS14390	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
B1865_RS14400	COG4566	intracellular signal transduction
B1865_RS14405	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
B1865_RS14410	COG0339	signal peptide processing
B1865_RS14415	COG1999	signal sequence binding
B1865_RS14435	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B1865_RS14445	COG1187	pseudouridine synthase activity
B1865_RS14450	COG3161	chorismate lyase activity
B1865_RS14455	COG2814	Major facilitator Superfamily
B1865_RS14465	COG0667	Aldo Keto reductase
B1865_RS14480	COG0335	large ribosomal subunit rRNA binding
B1865_RS14510	COG0175	sulfate reduction
B1865_RS14515	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
B1865_RS14520	COG4208	sulfate ABC transporter
B1865_RS14525	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
B1865_RS14540	COG0450	alkyl hydroperoxide reductase
B1865_RS14545	COG1960	acyl-CoA dehydrogenase activity
B1865_RS14560	COG0123	including yeast histone deacetylase and acetoin utilization protein
B1865_RS14565	COG2951	lytic endotransglycosylase activity
B1865_RS14580	COG1555	photosystem II stabilization
B1865_RS14580	COG1596	polysaccharide export
B1865_RS14585	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B1865_RS14590	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
B1865_RS14595	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
B1865_RS14615	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
B1865_RS14620	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
B1865_RS14625	COG0287	Prephenate dehydrogenase
B1865_RS14635	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
B1865_RS14650	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
B1865_RS14660	COG2814	Major facilitator Superfamily
B1865_RS14680	COG0583	DNA-binding transcription factor activity
B1865_RS14715	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
B1865_RS14730	COG0667	Aldo Keto reductase
B1865_RS14740	COG5265	(ABC) transporter
B1865_RS14785	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B1865_RS14790	COG0439	Biotin carboxylase
B1865_RS14795	COG2188	Transcriptional regulator
B1865_RS14820	COG0511	ligase activity, forming carbon-carbon bonds
B1865_RS14830	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
B1865_RS14850	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
B1865_RS14865	COG0500	methyltransferase
B1865_RS14870	COG5265	(ABC) transporter
B1865_RS14885	COG0028	Belongs to the TPP enzyme family
B1865_RS14890	COG0440	acetolactate synthase activity
B1865_RS14895	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
B1865_RS14900	COG1183	phosphatidylcholine synthase activity
B1865_RS14910	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
B1865_RS14915	COG1185	polyribonucleotide nucleotidyltransferase activity
B1865_RS14930	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
B1865_RS14950	COG0149	triose-phosphate isomerase activity
B1865_RS14955	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
B1865_RS14965	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
B1865_RS14975	COG3799	methylaspartate ammonia-lyase activity
B1865_RS15015	COG0583	DNA-binding transcription factor activity
B1865_RS15020	COG0626	cystathionine gamma-synthase activity
B1865_RS15025	COG3608	succinylglutamate desuccinylase aspartoacylase
B1865_RS15045	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B1865_RS15065	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
B1865_RS15080	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B1865_RS15085	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B1865_RS15090	COG1733	regulation of RNA biosynthetic process
B1865_RS15100	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
B1865_RS15105	COG0583	DNA-binding transcription factor activity
B1865_RS15110	COG1597	lipid kinase activity
B1865_RS15120	COG0671	phosphoesterase, PA-phosphatase related
B1865_RS15145	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
B1865_RS15150	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B1865_RS15155	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B1865_RS15160	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B1865_RS15165	COG0649	NAD binding
B1865_RS15170	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
B1865_RS15180	COG1034	ATP synthesis coupled electron transport
B1865_RS15185	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
B1865_RS15190	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B1865_RS15200	COG0713	ATP synthesis coupled electron transport
B1865_RS15215	COG1007	ATP synthesis coupled electron transport
B1865_RS15225	COG4774	siderophore transport
B1865_RS15230	COG4774	siderophore transport
B1865_RS15245	COG0028	Belongs to the TPP enzyme family
B1865_RS15250	COG3181	Tripartite tricarboxylate transporter family receptor
B1865_RS15255	COG0583	DNA-binding transcription factor activity
B1865_RS15260	COG0560	Phosphoserine phosphatase
B1865_RS15265	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
B1865_RS15270	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
B1865_RS15275	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
B1865_RS15285	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
B1865_RS15290	COG0308	aminopeptidase N
B1865_RS15310	COG0028	Belongs to the TPP enzyme family
B1865_RS15330	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B1865_RS15340	COG0318	PFAM AMP-dependent synthetase and ligase
B1865_RS15350	COG1802	Transcriptional regulator
B1865_RS15360	COG1802	Transcriptional regulator
B1865_RS15370	COG1028	Short-chain dehydrogenase reductase Sdr
B1865_RS15390	COG1126	abc transporter atp-binding protein
B1865_RS15395	COG0765	amino acid transport
B1865_RS15415	COG1538	Outer membrane efflux protein
B1865_RS15420	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B1865_RS15425	COG2274	protein secretion by the type I secretion system
B1865_RS15430	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
B1865_RS15440	COG2994	toxin metabolic process
B1865_RS15455	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B1865_RS15460	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
B1865_RS15470	COG0583	DNA-binding transcription factor activity
B1865_RS15480	COG0142	geranyltranstransferase activity
B1865_RS15490	COG0261	This protein binds to 23S rRNA in the presence of protein L20
B1865_RS15495	COG0211	Belongs to the bacterial ribosomal protein bL27 family
B1865_RS15500	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
B1865_RS15505	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
B1865_RS15545	COG3712	iron ion homeostasis
B1865_RS15550	COG4774	siderophore transport
B1865_RS15555	COG2353	YceI-like domain
B1865_RS15575	COG0019	diaminopimelate decarboxylase activity
B1865_RS15595	COG0747	negative chemotaxis
B1865_RS15600	COG0601	transmembrane transport
B1865_RS15605	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B1865_RS15615	COG0154	amidase activity
B1865_RS15620	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B1865_RS15645	COG2154	pterin-4-alpha-carbinolamine dehydratase
B1865_RS15655	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
B1865_RS15665	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
B1865_RS15670	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B1865_RS15675	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
B1865_RS15680	COG1929	Belongs to the glycerate kinase type-1 family
B1865_RS15685	COG0469	pyruvate kinase activity
B1865_RS15690	COG0700	Nucleoside recognition
B1865_RS15720	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
B1865_RS15725	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B1865_RS15740	COG0823	Involved in the tonB-independent uptake of proteins
B1865_RS15750	COG0848	biopolymer transport protein
B1865_RS15755	COG0811	peptide transport
B1865_RS15760	COG0824	Thioesterase
B1865_RS15765	COG0442	prolyl-tRNA aminoacylation
B1865_RS15770	COG0494	nUDIX hydrolase
B1865_RS15785	COG2135	peptidase activity
B1865_RS15850	COG1196	nuclear chromosome segregation
B1865_RS15990	COG1464	Belongs to the NlpA lipoprotein family
B1865_RS16020	COG4211	Belongs to the binding-protein-dependent transport system permease family
B1865_RS16030	COG0154	amidase activity
B1865_RS16035	COG0288	reversible hydration of carbon dioxide
B1865_RS16050	COG0514	ATP-dependent DNA helicase (RecQ)
B1865_RS16055	COG2255	four-way junction helicase activity
B1865_RS16070	COG0632	four-way junction helicase activity
B1865_RS16075	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
B1865_RS16095	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B1865_RS16105	COG0006	proline dipeptidase activity
B1865_RS16130	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
B1865_RS16145	COG4783	chaperone-mediated protein folding
B1865_RS16150	COG0429	hydrolase of the alpha beta-hydrolase fold
B1865_RS16180	COG0513	Belongs to the DEAD box helicase family
B1865_RS16200	COG1058	Belongs to the CinA family
B1865_RS16200	COG1546	Belongs to the CinA family
B1865_RS16205	COG1414	Transcriptional regulator
B1865_RS16225	COG0167	dihydroorotate dehydrogenase activity
B1865_RS16230	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
B1865_RS16240	COG0583	DNA-binding transcription factor activity
B1865_RS16300	COG0280	phosphate acetyltransferase
B1865_RS16300	COG0281	malic enzyme
B1865_RS16310	COG0601	transmembrane transport
B1865_RS16315	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B1865_RS16320	COG4172	Belongs to the ABC transporter superfamily
B1865_RS16350	COG0640	Transcriptional regulator
B1865_RS16365	COG3135	benzoate transporter
B1865_RS16370	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
B1865_RS16375	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
B1865_RS16380	COG0742	ribosomal rna small subunit methyltransferase
B1865_RS16400	COG3639	organic phosphonate transmembrane transporter activity
B1865_RS16405	COG3639	organic phosphonate transmembrane transporter activity
B1865_RS16410	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
B1865_RS16445	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
B1865_RS16450	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B1865_RS16460	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
B1865_RS16465	COG1058	Belongs to the CinA family
B1865_RS16465	COG1546	Belongs to the CinA family
B1865_RS16470	COG0284	orotidine-5'-phosphate decarboxylase activity
B1865_RS16475	COG1252	NADH dehydrogenase
B1865_RS16490	COG3468	outer membrane autotransporter barrel domain protein
B1865_RS16495	COG0459	protein refolding
B1865_RS16500	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
B1865_RS16520	COG1053	succinate dehydrogenase
B1865_RS16530	COG0583	DNA-binding transcription factor activity
B1865_RS16535	COG1053	succinate dehydrogenase
B1865_RS16555	COG3706	GGDEF domain
B1865_RS16590	COG1262	PFAM Formylglycine-generating sulfatase enzyme
B1865_RS16595	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
B1865_RS16605	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B1865_RS16615	COG0069	glutamate synthase activity
B1865_RS16620	COG2391	methyltransferase activity
B1865_RS16625	COG0679	Auxin Efflux Carrier
B1865_RS16650	COG0557	exoribonuclease II activity
B1865_RS16655	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B1865_RS16665	COG3128	pkhd-type hydroxylase
B1865_RS16670	COG0776	regulation of translation
B1865_RS16700	COG0642	Histidine kinase
B1865_RS16705	COG3158	transport of potassium into the cell
B1865_RS16710	COG0137	argininosuccinate synthase activity
B1865_RS16715	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
B1865_RS16720	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B1865_RS16730	COG0583	DNA-binding transcription factor activity
B1865_RS16740	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B1865_RS16760	COG2186	Transcriptional regulator
B1865_RS16770	COG2223	nitrite transmembrane transporter activity
B1865_RS16780	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B1865_RS16785	COG0450	alkyl hydroperoxide reductase
B1865_RS16800	COG1214	PFAM Peptidase M22, glycoprotease
B1865_RS16805	COG1573	uracil-dna glycosylase
B1865_RS16810	COG0477	Major facilitator Superfamily
B1865_RS16815	COG1196	nuclear chromosome segregation
B1865_RS16825	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
B1865_RS16830	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B1865_RS16845	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B1865_RS16850	COG1122	ATPase activity
B1865_RS16855	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
B1865_RS16860	COG1268	BioY protein
B1865_RS16880	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B1865_RS16915	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
B1865_RS16920	COG2878	Part of a membrane complex involved in electron transport
B1865_RS16935	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
B1865_RS16940	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
B1865_RS16945	COG0251	oxidation-reduction process
B1865_RS16955	COG3228	Belongs to the MtfA family
B1865_RS16960	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B1865_RS16970	COG0133	tryptophan synthase activity
B1865_RS16975	COG0159	tryptophan synthase activity
B1865_RS16980	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
B1865_RS16985	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
B1865_RS17000	COG1530	ribonuclease E activity
B1865_RS17010	COG0546	phosphoglycolate phosphatase activity
B1865_RS17015	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
B1865_RS17020	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
B1865_RS17030	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B1865_RS17035	COG0583	DNA-binding transcription factor activity
B1865_RS17045	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B1865_RS17070	COG0251	oxidation-reduction process
B1865_RS17075	COG1017	nitric oxide dioxygenase activity
B1865_RS17075	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
B1865_RS17080	COG2031	fatty acid transporter
B1865_RS17085	COG1012	belongs to the aldehyde dehydrogenase family
B1865_RS17090	COG1802	Transcriptional regulator
B1865_RS17100	COG1278	Cold shock
B1865_RS17105	COG0583	DNA-binding transcription factor activity
B1865_RS17125	COG0183	Belongs to the thiolase family
B1865_RS17135	COG1960	acyl-CoA dehydrogenase activity
B1865_RS17140	COG0583	DNA-binding transcription factor activity
B1865_RS17145	COG3181	Tripartite tricarboxylate transporter family receptor
B1865_RS17150	COG1024	Enoyl-CoA hydratase
B1865_RS17155	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B1865_RS17160	COG1253	flavin adenine dinucleotide binding
B1865_RS17165	COG1285	pathogenesis
B1865_RS17175	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B1865_RS17190	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
B1865_RS17200	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B1865_RS17210	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B1865_RS17215	COG3181	Tripartite tricarboxylate transporter family receptor
B1865_RS17220	COG1960	acyl-CoA dehydrogenase activity
B1865_RS17240	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B1865_RS17245	COG1024	Enoyl-CoA hydratase
B1865_RS17250	COG1960	acyl-CoA dehydrogenase activity
B1865_RS17270	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
B1865_RS17275	COG0022	dehydrogenase e1 component
B1865_RS17280	COG1024	Enoyl-CoA hydratase
B1865_RS17285	COG0508	dehydrogenase complex catalyzes the overall conversion of
B1865_RS17305	COG0683	leucine binding
B1865_RS17310	COG0559	Belongs to the binding-protein-dependent transport system permease family
B1865_RS17315	COG0411	ABC transporter
B1865_RS17325	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B1865_RS17340	COG3181	Tripartite tricarboxylate transporter family receptor
B1865_RS17365	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
B1865_RS17370	COG0793	Belongs to the peptidase S41A family
B1865_RS17375	COG4942	peptidase
B1865_RS17380	COG0588	phosphoglycerate mutase activity
B1865_RS17385	COG1054	Belongs to the UPF0176 family
B1865_RS17390	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
B1865_RS17395	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
B1865_RS17400	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
B1865_RS17405	COG3181	Tripartite tricarboxylate transporter family receptor
B1865_RS17420	COG2226	methyltransferase
B1865_RS17425	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
B1865_RS17440	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B1865_RS17445	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
B1865_RS17470	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
B1865_RS17495	COG1335	isochorismatase
B1865_RS17500	COG2309	aminopeptidase activity
B1865_RS17505	COG0596	Alpha beta hydrolase
B1865_RS17510	COG3473	Maleate cis-trans isomerase
B1865_RS17520	COG2068	MobA-Related Protein
B1865_RS17545	COG2204	response regulator
B1865_RS17550	COG5000	phosphorelay sensor kinase activity
B1865_RS17560	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B1865_RS17560	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
B1865_RS17570	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
B1865_RS17595	COG0583	DNA-binding transcription factor activity
B1865_RS17610	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
B1865_RS17615	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B1865_RS17620	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B1865_RS17635	COG0758	DNA mediated transformation
B1865_RS17640	COG1522	sequence-specific DNA binding
B1865_RS17650	COG0242	peptide deformylase activity
B1865_RS17660	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
B1865_RS17670	COG0546	phosphoglycolate phosphatase activity
B1865_RS17690	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B1865_RS17695	COG1942	4-Oxalocrotonate Tautomerase
B1865_RS17700	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B1865_RS17720	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B1865_RS17740	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B1865_RS17745	COG1024	Enoyl-CoA hydratase
B1865_RS17750	COG1414	Transcriptional regulator
B1865_RS17755	COG0318	PFAM AMP-dependent synthetase and ligase
B1865_RS17760	COG3181	Tripartite tricarboxylate transporter family receptor
B1865_RS17790	COG0583	DNA-binding transcription factor activity
B1865_RS17805	COG3422	double-strand break repair
B1865_RS17810	COG0330	HflC and HflK could
B1865_RS17820	COG0251	oxidation-reduction process
B1865_RS17865	COG3723	Recombinational DNA repair protein, rece pathway
B1865_RS17900	COG0582	viral genome integration into host DNA
B1865_RS17925	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
B1865_RS17935	COG0706	membrane insertase activity
B1865_RS17940	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
B1865_RS17945	COG0594	ribonuclease P activity
B1865_RS17950	COG0230	Belongs to the bacterial ribosomal protein bL34 family
B1865_RS17955	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
B1865_RS17970	COG1414	Transcriptional regulator
B1865_RS17975	COG0154	amidase activity
B1865_RS17990	COG1304	FMN binding
B1865_RS18010	COG1960	acyl-CoA dehydrogenase activity
B1865_RS18030	COG1960	acyl-CoA dehydrogenase activity
B1865_RS18040	COG0183	Belongs to the thiolase family
B1865_RS18045	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B1865_RS18060	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B1865_RS18065	COG3181	Tripartite tricarboxylate transporter family receptor
B1865_RS18075	COG2358	TRAP transporter, solute receptor (TAXI family
B1865_RS18085	COG1629	transport
B1865_RS18090	COG2922	Belongs to the Smg family
B1865_RS18115	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
B1865_RS18120	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B1865_RS18125	COG1028	Short-chain dehydrogenase reductase Sdr
B1865_RS18130	COG1012	belongs to the aldehyde dehydrogenase family
B1865_RS18140	COG0028	Belongs to the TPP enzyme family
B1865_RS18145	COG1522	sequence-specific DNA binding
B1865_RS18150	COG3781	membrane
B1865_RS18160	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B1865_RS18180	COG4206	TonB-dependent receptor
B1865_RS18185	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B1865_RS18190	COG2022	thiamine diphosphate biosynthetic process
B1865_RS18195	COG0351	phosphomethylpyrimidine kinase
B1865_RS18200	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
B1865_RS18215	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
B1865_RS18225	COG0628	permease
B1865_RS18235	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
B1865_RS18245	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
B1865_RS18250	COG0049	tRNA binding
B1865_RS18255	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
B1865_RS18260	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B1865_RS18265	COG0051	transcription antitermination factor activity, RNA binding
B1865_RS18270	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
B1865_RS18275	COG0088	Forms part of the polypeptide exit tunnel
B1865_RS18280	COG0089	rRNA binding
B1865_RS18285	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
B1865_RS18290	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
B1865_RS18295	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
B1865_RS18300	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
B1865_RS18305	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
B1865_RS18310	COG0255	Belongs to the universal ribosomal protein uL29 family
B1865_RS18315	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
B1865_RS18335	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
B1865_RS18340	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
B1865_RS18345	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
B1865_RS18350	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
B1865_RS18355	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
B1865_RS18360	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
B1865_RS18365	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
B1865_RS18370	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
B1865_RS18375	COG1841	ribosomal large subunit assembly
B1865_RS18380	COG0200	Binds to the 23S rRNA
B1865_RS18385	COG0201	protein transport
B1865_RS18390	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
B1865_RS18395	COG0257	Belongs to the bacterial ribosomal protein bL36 family
B1865_RS18400	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
B1865_RS18405	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
B1865_RS18410	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
B1865_RS18415	COG0202	RNA polymerase activity
B1865_RS18420	COG0203	ribosomal protein L17
B1865_RS18430	COG1324	tolerance protein
B1865_RS18435	COG4232	protein-disulfide reductase activity
B1865_RS18450	COG0218	Necessary for normal cell division and for the maintenance of normal septation
B1865_RS18460	COG1333	cytochrome c biogenesis protein
B1865_RS18465	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B1865_RS18475	COG1965	Belongs to the frataxin family
B1865_RS18485	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
B1865_RS18490	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
B1865_RS18495	COG0232	Belongs to the dGTPase family. Type 2 subfamily
B1865_RS18510	COG2814	Major facilitator Superfamily
B1865_RS18515	COG0629	single-stranded DNA binding
B1865_RS18555	COG0402	S-adenosylhomocysteine deaminase activity
B1865_RS18565	COG0438	transferase activity, transferring glycosyl groups
B1865_RS18585	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B1865_RS18610	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
B1865_RS18615	COG2186	Transcriptional regulator
B1865_RS18635	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B1865_RS18640	COG1956	GAF domain-containing protein
B1865_RS18645	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B1865_RS18655	COG1652	LysM domain
B1865_RS18670	COG0220	tRNA (guanine-N7-)-methyltransferase activity
B1865_RS18685	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B1865_RS18710	COG3181	Tripartite tricarboxylate transporter family receptor
B1865_RS18725	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B1865_RS18740	COG1024	Enoyl-CoA hydratase
B1865_RS18755	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B1865_RS18760	COG1309	transcriptional regulator
B1865_RS18765	COG2816	NAD+ diphosphatase activity
B1865_RS18770	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
B1865_RS18855	COG2814	Major facilitator Superfamily
B1865_RS18860	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
B1865_RS18880	COG1999	signal sequence binding
B1865_RS18885	COG0109	protoheme IX farnesyltransferase activity
B1865_RS18925	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
B1865_RS18945	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
B1865_RS18950	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
B1865_RS18960	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
B1865_RS18965	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
B1865_RS18975	COG0069	glutamate synthase activity
B1865_RS18975	COG0067	glutamate synthase
B1865_RS18975	COG0070	glutamate synthase
B1865_RS18985	COG3047	cAMP biosynthetic process
B1865_RS18995	COG1127	ABC transporter
B1865_RS19000	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
B1865_RS19005	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
B1865_RS19010	COG2853	Lipoprotein
B1865_RS19020	COG1131	(ABC) transporter
B1865_RS19025	COG0842	Transport permease protein
B1865_RS19035	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
B1865_RS19040	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
B1865_RS19045	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
B1865_RS19050	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B1865_RS19055	COG0131	Imidazoleglycerol-phosphate dehydratase
B1865_RS19060	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
B1865_RS19065	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
B1865_RS19070	COG0107	imidazoleglycerol-phosphate synthase activity
B1865_RS19075	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
B1865_RS19080	COG0140	phosphoribosyl-ATP diphosphatase activity
B1865_RS19085	COG0537	adenosine 5'-monophosphoramidase activity
B1865_RS19090	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B1865_RS19095	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B1865_RS19110	COG3181	Tripartite tricarboxylate transporter family receptor
B1865_RS19145	COG3702	type iv secretory pathway
B1865_RS19150	COG3451	type IV secretory pathway VirB4
B1865_RS19165	COG3736	Type IV secretory pathway, component VirB8
B1865_RS19170	COG3504	Conjugal transfer protein
B1865_RS19175	COG2948	multi-organism process
B1865_RS19180	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
B1865_RS19190	COG0697	spore germination
B1865_RS19210	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
B1865_RS19215	COG0747	negative chemotaxis
B1865_RS19220	COG0601	transmembrane transport
B1865_RS19225	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B1865_RS19230	COG0444	Belongs to the ABC transporter superfamily
B1865_RS19240	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
B1865_RS19250	COG0494	nUDIX hydrolase
B1865_RS19290	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
B1865_RS19295	COG0237	dephospho-CoA kinase activity
B1865_RS19300	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
B1865_RS19315	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
B1865_RS19320	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
B1865_RS19330	COG0477	Major facilitator Superfamily
B1865_RS19335	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
B1865_RS19350	COG1126	abc transporter atp-binding protein
B1865_RS19355	COG0765	amino acid transport
B1865_RS19360	COG4597	amino acid ABC transporter
B1865_RS19365	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B1865_RS19370	COG2884	Cell division ATP-binding protein ftsE
B1865_RS19375	COG2177	Part of the ABC transporter FtsEX involved in
B1865_RS19380	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
B1865_RS19390	COG1194	a g-specific adenine glycosylase
B1865_RS19400	COG2226	methyltransferase
B1865_RS19410	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B1865_RS19415	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B1865_RS19430	COG1024	Enoyl-CoA hydratase
B1865_RS19450	COG1024	Enoyl-CoA hydratase
B1865_RS19455	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B1865_RS19460	COG3181	Tripartite tricarboxylate transporter family receptor
B1865_RS19470	COG0753	catalase activity
B1865_RS19475	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B1865_RS19480	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
B1865_RS19490	COG2175	clavaminate synthase activity
B1865_RS19495	COG1473	amidohydrolase
B1865_RS19500	COG4608	Belongs to the ABC transporter superfamily
B1865_RS19505	COG0444	Belongs to the ABC transporter superfamily
B1865_RS19520	COG0747	negative chemotaxis
B1865_RS19525	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
B1865_RS19560	COG0436	Aminotransferase
B1865_RS19565	COG1278	Cold shock