locus-tag	class	description
B3921_RS00005	COG0445	tRNA wobble uridine modification
B3921_RS00010	COG0357	Ribosomal RNA small subunit methyltransferase G
B3921_RS00015	COG1192	Involved in chromosome partitioning
B3921_RS00025	COG1475	DNA binding
B3921_RS00030	COG0252	asparaginase activity
B3921_RS00055	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B3921_RS00065	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
B3921_RS00075	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
B3921_RS00080	COG0081	regulation of translation
B3921_RS00085	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
B3921_RS00090	COG0222	ribosome binding
B3921_RS00095	COG0085	RNA polymerase activity
B3921_RS00100	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
B3921_RS00140	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B3921_RS00165	COG1024	Enoyl-CoA hydratase
B3921_RS00185	COG0752	glycyl-tRNA synthetase alpha subunit
B3921_RS00190	COG0751	glycine-tRNA ligase activity
B3921_RS00195	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
B3921_RS00200	COG0204	Acyl-transferase
B3921_RS00215	COG0242	peptide deformylase activity
B3921_RS00250	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
B3921_RS00255	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
B3921_RS00260	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
B3921_RS00260	COG2813	Specifically methylates the guanine in position
B3921_RS00270	COG2223	nitrite transmembrane transporter activity
B3921_RS00280	COG1794	racemase activity, acting on amino acids and derivatives
B3921_RS00285	COG1126	abc transporter atp-binding protein
B3921_RS00290	COG0765	amino acid transport
B3921_RS00295	COG0765	amino acid transport
B3921_RS00300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B3921_RS00355	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
B3921_RS00385	COG0326	Molecular chaperone. Has ATPase activity
B3921_RS00390	COG0625	glutathione transferase activity
B3921_RS00405	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B3921_RS00410	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
B3921_RS00440	COG0438	transferase activity, transferring glycosyl groups
B3921_RS00445	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
B3921_RS00450	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
B3921_RS00480	COG0859	PFAM glycosyl transferase family 9
B3921_RS00495	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
B3921_RS00505	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
B3921_RS00510	COG1127	ABC transporter
B3921_RS00535	COG1686	Belongs to the peptidase S11 family
B3921_RS00545	COG2921	Belongs to the UPF0250 family
B3921_RS00550	COG0321	lipoyl(octanoyl) transferase activity
B3921_RS00555	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
B3921_RS00590	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
B3921_RS00600	COG0018	arginyl-trna synthetase
B3921_RS00620	COG0395	ABC-type sugar transport system, permease component
B3921_RS00625	COG1175	transmembrane transport
B3921_RS00630	COG1653	transport
B3921_RS00635	COG3842	ATPase activity
B3921_RS00640	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
B3921_RS00655	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
B3921_RS00675	COG1609	Transcriptional regulator
B3921_RS00685	COG0154	amidase activity
B3921_RS00690	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B3921_RS00700	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
B3921_RS00710	COG0583	DNA-binding transcription factor activity
B3921_RS00725	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
B3921_RS00730	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
B3921_RS00745	COG1802	Transcriptional regulator
B3921_RS00760	COG1024	Enoyl-CoA hydratase
B3921_RS00775	COG3181	Tripartite tricarboxylate transporter family receptor
B3921_RS00790	COG1984	allophanate hydrolase subunit 2
B3921_RS00795	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
B3921_RS00805	COG0583	DNA-binding transcription factor activity
B3921_RS00810	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B3921_RS00820	COG5002	protein histidine kinase activity
B3921_RS00830	COG5002	protein histidine kinase activity
B3921_RS00835	COG0745	RESPONSE REGULATOR receiver
B3921_RS00840	COG2226	methyltransferase
B3921_RS00855	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
B3921_RS00875	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
B3921_RS00885	COG0513	Belongs to the DEAD box helicase family
B3921_RS00890	COG1280	lysine exporter protein (LysE YggA)
B3921_RS00895	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
B3921_RS00930	COG1054	Belongs to the UPF0176 family
B3921_RS00935	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B3921_RS00935	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B3921_RS00945	COG0489	protein tyrosine kinase activity
B3921_RS00960	COG0717	Belongs to the dCTP deaminase family
B3921_RS00990	COG2081	HI0933 family
B3921_RS01000	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
B3921_RS01010	COG0404	The glycine cleavage system catalyzes the degradation of glycine
B3921_RS01015	COG0509	glycine decarboxylation via glycine cleavage system
B3921_RS01020	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B3921_RS01020	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B3921_RS01060	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
B3921_RS01075	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
B3921_RS01085	COG1414	Transcriptional regulator
B3921_RS01090	COG1028	Short-chain dehydrogenase reductase Sdr
B3921_RS01095	COG2031	fatty acid transporter
B3921_RS01100	COG1250	3-hydroxyacyl-CoA dehydrogenase
B3921_RS01110	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
B3921_RS01115	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
B3921_RS01125	COG4257	antibiotic catabolic process
B3921_RS01145	COG1012	belongs to the aldehyde dehydrogenase family
B3921_RS01150	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
B3921_RS01155	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B3921_RS01180	COG1028	Short-chain dehydrogenase reductase Sdr
B3921_RS01190	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B3921_RS01200	COG2188	Transcriptional regulator
B3921_RS01205	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
B3921_RS01230	COG0617	tRNA 3'-terminal CCA addition
B3921_RS01245	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
B3921_RS01250	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
B3921_RS01255	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
B3921_RS01260	COG0586	Pfam SNARE associated Golgi protein
B3921_RS01265	COG0860	N-Acetylmuramoyl-L-alanine amidase
B3921_RS01270	COG0802	atpase or kinase
B3921_RS01275	COG0114	fumarate hydratase activity
B3921_RS01285	COG3181	Tripartite tricarboxylate transporter family receptor
B3921_RS01295	COG0405	Gamma-glutamyltransferase
B3921_RS01300	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B3921_RS01310	COG1960	acyl-CoA dehydrogenase activity
B3921_RS01335	COG1294	oxidase, subunit
B3921_RS01345	COG4988	ABC transporter
B3921_RS01350	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
B3921_RS01355	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B3921_RS01370	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
B3921_RS01395	COG2969	positive regulation of protein catabolic process
B3921_RS01400	COG0625	glutathione transferase activity
B3921_RS01405	COG2857	Cytochrome c1
B3921_RS01410	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
B3921_RS01415	COG0723	plastoquinol--plastocyanin reductase activity
B3921_RS01420	COG1970	mechanosensitive ion channel activity
B3921_RS01425	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
B3921_RS01440	COG2808	Putative FMN-binding domain
B3921_RS01445	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B3921_RS01450	COG0747	negative chemotaxis
B3921_RS01455	COG0657	acetylesterase activity
B3921_RS01465	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B3921_RS01470	COG2207	Transcriptional regulator
B3921_RS01475	COG0129	dihydroxy-acid dehydratase activity
B3921_RS01480	COG2814	Major facilitator Superfamily
B3921_RS01485	COG0583	DNA-binding transcription factor activity
B3921_RS01495	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
B3921_RS01565	COG1024	Enoyl-CoA hydratase
B3921_RS01570	COG1960	acyl-CoA dehydrogenase activity
B3921_RS01595	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
B3921_RS01600	COG0352	thiamine-phosphate diphosphorylase activity
B3921_RS01615	COG1678	Uncharacterized ACR, COG1678
B3921_RS01620	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
B3921_RS01625	COG0540	Belongs to the ATCase OTCase family
B3921_RS01640	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
B3921_RS01650	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B3921_RS01685	COG1234	tRNA 3'-trailer cleavage
B3921_RS01730	COG1683	Conserved Protein
B3921_RS01735	COG1120	ATPase activity
B3921_RS01740	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B3921_RS01745	COG4558	Periplasmic binding protein
B3921_RS01750	COG3720	iron ion transport
B3921_RS01760	COG3712	iron ion homeostasis
B3921_RS01765	COG1595	DNA-templated transcription, initiation
B3921_RS01800	COG1802	Transcriptional regulator
B3921_RS01810	COG3069	C4-dicarboxylate transmembrane transporter activity
B3921_RS01820	COG1012	belongs to the aldehyde dehydrogenase family
B3921_RS01855	COG2860	membrane
B3921_RS01860	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
B3921_RS01865	COG0708	Exodeoxyribonuclease III
B3921_RS01870	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
B3921_RS01875	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B3921_RS01880	COG0154	amidase activity
B3921_RS01885	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B3921_RS01890	COG1077	Cell shape determining protein MreB Mrl
B3921_RS01895	COG1792	Involved in formation and maintenance of cell shape
B3921_RS01905	COG0768	penicillin binding
B3921_RS01910	COG0772	Belongs to the SEDS family
B3921_RS01915	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
B3921_RS01920	COG0471	metal ion transport
B3921_RS01925	COG1309	transcriptional regulator
B3921_RS01935	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
B3921_RS01950	COG2823	Periplasmic or secreted lipoprotein
B3921_RS01955	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
B3921_RS01970	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
B3921_RS01990	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B3921_RS02000	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B3921_RS02025	COG0492	ferredoxin-NADP+ reductase activity
B3921_RS02035	COG3181	Tripartite tricarboxylate transporter family receptor
B3921_RS02040	COG1024	Enoyl-CoA hydratase
B3921_RS02040	COG1250	3-hydroxyacyl-CoA dehydrogenase
B3921_RS02045	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B3921_RS02050	COG0028	Belongs to the TPP enzyme family
B3921_RS02075	COG3181	Tripartite tricarboxylate transporter family receptor
B3921_RS02085	COG0697	spore germination
B3921_RS02110	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
B3921_RS02115	COG0463	Glycosyl transferase, family 2
B3921_RS02130	COG0786	glutamate:sodium symporter activity
B3921_RS02140	COG2031	fatty acid transporter
B3921_RS02155	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
B3921_RS02160	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B3921_RS02170	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
B3921_RS02185	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B3921_RS02195	COG1285	pathogenesis
B3921_RS02200	COG1253	flavin adenine dinucleotide binding
B3921_RS02205	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B3921_RS02210	COG1024	Enoyl-CoA hydratase
B3921_RS02215	COG3181	Tripartite tricarboxylate transporter family receptor
B3921_RS02220	COG0583	DNA-binding transcription factor activity
B3921_RS02225	COG1960	acyl-CoA dehydrogenase activity
B3921_RS02235	COG0183	Belongs to the thiolase family
B3921_RS02255	COG0583	DNA-binding transcription factor activity
B3921_RS02260	COG1278	Cold shock
B3921_RS02270	COG1802	Transcriptional regulator
B3921_RS02275	COG1012	belongs to the aldehyde dehydrogenase family
B3921_RS02280	COG2031	fatty acid transporter
B3921_RS02285	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
B3921_RS02285	COG1017	nitric oxide dioxygenase activity
B3921_RS02290	COG0251	oxidation-reduction process
B3921_RS02315	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B3921_RS02325	COG0583	DNA-binding transcription factor activity
B3921_RS02330	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B3921_RS02340	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
B3921_RS02345	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
B3921_RS02350	COG0546	phosphoglycolate phosphatase activity
B3921_RS02360	COG1530	ribonuclease E activity
B3921_RS02375	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
B3921_RS02380	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
B3921_RS02385	COG0159	tryptophan synthase activity
B3921_RS02390	COG0133	tryptophan synthase activity
B3921_RS02400	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B3921_RS02405	COG3228	Belongs to the MtfA family
B3921_RS02415	COG0251	oxidation-reduction process
B3921_RS02420	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
B3921_RS02425	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
B3921_RS02440	COG2878	Part of a membrane complex involved in electron transport
B3921_RS02445	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
B3921_RS02480	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B3921_RS02500	COG1268	BioY protein
B3921_RS02505	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
B3921_RS02510	COG1122	ATPase activity
B3921_RS02515	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B3921_RS02530	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B3921_RS02535	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
B3921_RS02545	COG1196	nuclear chromosome segregation
B3921_RS02550	COG0477	Major facilitator Superfamily
B3921_RS02555	COG1573	uracil-dna glycosylase
B3921_RS02560	COG1214	PFAM Peptidase M22, glycoprotease
B3921_RS02575	COG0450	alkyl hydroperoxide reductase
B3921_RS02580	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B3921_RS02590	COG2223	nitrite transmembrane transporter activity
B3921_RS02600	COG2186	Transcriptional regulator
B3921_RS02620	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B3921_RS02630	COG0583	DNA-binding transcription factor activity
B3921_RS02640	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B3921_RS02645	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
B3921_RS02650	COG0137	argininosuccinate synthase activity
B3921_RS02655	COG3158	transport of potassium into the cell
B3921_RS02660	COG0642	Histidine kinase
B3921_RS02690	COG0776	regulation of translation
B3921_RS02695	COG3128	pkhd-type hydroxylase
B3921_RS02705	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B3921_RS02710	COG0557	exoribonuclease II activity
B3921_RS02735	COG0679	Auxin Efflux Carrier
B3921_RS02740	COG2391	methyltransferase activity
B3921_RS02745	COG0069	glutamate synthase activity
B3921_RS02755	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B3921_RS02765	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
B3921_RS02770	COG1262	PFAM Formylglycine-generating sulfatase enzyme
B3921_RS02805	COG3706	GGDEF domain
B3921_RS02825	COG1053	succinate dehydrogenase
B3921_RS02830	COG0583	DNA-binding transcription factor activity
B3921_RS02840	COG1053	succinate dehydrogenase
B3921_RS02860	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
B3921_RS02865	COG0459	protein refolding
B3921_RS02870	COG3468	outer membrane autotransporter barrel domain protein
B3921_RS02885	COG1252	NADH dehydrogenase
B3921_RS02890	COG0284	orotidine-5'-phosphate decarboxylase activity
B3921_RS02895	COG1546	Belongs to the CinA family
B3921_RS02895	COG1058	Belongs to the CinA family
B3921_RS02900	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
B3921_RS02910	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B3921_RS02915	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
B3921_RS02950	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
B3921_RS02955	COG3639	organic phosphonate transmembrane transporter activity
B3921_RS02960	COG3639	organic phosphonate transmembrane transporter activity
B3921_RS02980	COG0742	ribosomal rna small subunit methyltransferase
B3921_RS02985	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
B3921_RS02990	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
B3921_RS02995	COG3135	benzoate transporter
B3921_RS03010	COG0640	Transcriptional regulator
B3921_RS03040	COG4172	Belongs to the ABC transporter superfamily
B3921_RS03045	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B3921_RS03050	COG0601	transmembrane transport
B3921_RS03060	COG0281	malic enzyme
B3921_RS03060	COG0280	phosphate acetyltransferase
B3921_RS03120	COG0583	DNA-binding transcription factor activity
B3921_RS03130	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
B3921_RS03135	COG0167	dihydroorotate dehydrogenase activity
B3921_RS03155	COG1414	Transcriptional regulator
B3921_RS03160	COG1058	Belongs to the CinA family
B3921_RS03160	COG1546	Belongs to the CinA family
B3921_RS03180	COG0513	Belongs to the DEAD box helicase family
B3921_RS03210	COG0429	hydrolase of the alpha beta-hydrolase fold
B3921_RS03215	COG4783	chaperone-mediated protein folding
B3921_RS03230	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
B3921_RS03255	COG0006	proline dipeptidase activity
B3921_RS03265	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B3921_RS03285	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
B3921_RS03290	COG0632	four-way junction helicase activity
B3921_RS03305	COG2255	four-way junction helicase activity
B3921_RS03310	COG0514	ATP-dependent DNA helicase (RecQ)
B3921_RS03325	COG0288	reversible hydration of carbon dioxide
B3921_RS03330	COG0154	amidase activity
B3921_RS03340	COG4211	Belongs to the binding-protein-dependent transport system permease family
B3921_RS03370	COG1464	Belongs to the NlpA lipoprotein family
B3921_RS03510	COG1196	nuclear chromosome segregation
B3921_RS03575	COG2135	peptidase activity
B3921_RS03590	COG0494	nUDIX hydrolase
B3921_RS03595	COG0442	prolyl-tRNA aminoacylation
B3921_RS03600	COG0824	Thioesterase
B3921_RS03605	COG0811	peptide transport
B3921_RS03610	COG0848	biopolymer transport protein
B3921_RS03620	COG0823	Involved in the tonB-independent uptake of proteins
B3921_RS03635	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B3921_RS03640	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
B3921_RS03670	COG0700	Nucleoside recognition
B3921_RS03675	COG0469	pyruvate kinase activity
B3921_RS03680	COG1929	Belongs to the glycerate kinase type-1 family
B3921_RS03685	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
B3921_RS03690	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B3921_RS03695	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
B3921_RS03705	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
B3921_RS03715	COG2154	pterin-4-alpha-carbinolamine dehydratase
B3921_RS03740	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B3921_RS03745	COG0154	amidase activity
B3921_RS03755	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B3921_RS03760	COG0601	transmembrane transport
B3921_RS03765	COG0747	negative chemotaxis
B3921_RS03785	COG0019	diaminopimelate decarboxylase activity
B3921_RS03805	COG2353	YceI-like domain
B3921_RS03810	COG4774	siderophore transport
B3921_RS03815	COG3712	iron ion homeostasis
B3921_RS03855	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
B3921_RS03860	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
B3921_RS03865	COG0211	Belongs to the bacterial ribosomal protein bL27 family
B3921_RS03870	COG0261	This protein binds to 23S rRNA in the presence of protein L20
B3921_RS03880	COG0142	geranyltranstransferase activity
B3921_RS03890	COG0583	DNA-binding transcription factor activity
B3921_RS03900	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
B3921_RS03905	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B3921_RS03920	COG2994	toxin metabolic process
B3921_RS03930	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
B3921_RS03935	COG2274	protein secretion by the type I secretion system
B3921_RS03940	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B3921_RS03945	COG1538	Outer membrane efflux protein
B3921_RS03965	COG0765	amino acid transport
B3921_RS03970	COG1126	abc transporter atp-binding protein
B3921_RS03990	COG1028	Short-chain dehydrogenase reductase Sdr
B3921_RS04000	COG1802	Transcriptional regulator
B3921_RS04010	COG1802	Transcriptional regulator
B3921_RS04020	COG0318	PFAM AMP-dependent synthetase and ligase
B3921_RS04030	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B3921_RS04050	COG0028	Belongs to the TPP enzyme family
B3921_RS04070	COG0308	aminopeptidase N
B3921_RS04075	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
B3921_RS04090	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
B3921_RS04095	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
B3921_RS04100	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
B3921_RS04105	COG0560	Phosphoserine phosphatase
B3921_RS04110	COG0583	DNA-binding transcription factor activity
B3921_RS04115	COG3181	Tripartite tricarboxylate transporter family receptor
B3921_RS04120	COG0028	Belongs to the TPP enzyme family
B3921_RS04135	COG4774	siderophore transport
B3921_RS04140	COG4774	siderophore transport
B3921_RS04150	COG1007	ATP synthesis coupled electron transport
B3921_RS04165	COG0713	ATP synthesis coupled electron transport
B3921_RS04175	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B3921_RS04180	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
B3921_RS04185	COG1034	ATP synthesis coupled electron transport
B3921_RS04195	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
B3921_RS04200	COG0649	NAD binding
B3921_RS04205	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B3921_RS04210	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B3921_RS04215	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B3921_RS04220	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
B3921_RS04245	COG0671	phosphoesterase, PA-phosphatase related
B3921_RS04255	COG1597	lipid kinase activity
B3921_RS04260	COG0583	DNA-binding transcription factor activity
B3921_RS04265	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
B3921_RS04275	COG1733	regulation of RNA biosynthetic process
B3921_RS04280	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B3921_RS04285	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B3921_RS04300	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
B3921_RS04320	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B3921_RS04340	COG3608	succinylglutamate desuccinylase aspartoacylase
B3921_RS04345	COG0626	cystathionine gamma-synthase activity
B3921_RS04350	COG0583	DNA-binding transcription factor activity
B3921_RS04390	COG3799	methylaspartate ammonia-lyase activity
B3921_RS04400	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
B3921_RS04410	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
B3921_RS04415	COG0149	triose-phosphate isomerase activity
B3921_RS04435	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
B3921_RS04450	COG1185	polyribonucleotide nucleotidyltransferase activity
B3921_RS04455	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
B3921_RS04465	COG1183	phosphatidylcholine synthase activity
B3921_RS04470	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
B3921_RS04475	COG0440	acetolactate synthase activity
B3921_RS04480	COG0028	Belongs to the TPP enzyme family
B3921_RS04495	COG5265	(ABC) transporter
B3921_RS04500	COG0500	methyltransferase
B3921_RS04515	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
B3921_RS04535	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
B3921_RS04545	COG0511	ligase activity, forming carbon-carbon bonds
B3921_RS04570	COG2188	Transcriptional regulator
B3921_RS04575	COG0439	Biotin carboxylase
B3921_RS04580	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B3921_RS04625	COG5265	(ABC) transporter
B3921_RS04635	COG0667	Aldo Keto reductase
B3921_RS04650	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
B3921_RS04685	COG0583	DNA-binding transcription factor activity
B3921_RS04705	COG2814	Major facilitator Superfamily
B3921_RS04715	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
B3921_RS04730	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
B3921_RS04740	COG0287	Prephenate dehydrogenase
B3921_RS04745	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
B3921_RS04750	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
B3921_RS04770	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
B3921_RS04775	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
B3921_RS04780	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B3921_RS04785	COG1596	polysaccharide export
B3921_RS04785	COG1555	photosystem II stabilization
B3921_RS04800	COG2951	lytic endotransglycosylase activity
B3921_RS04805	COG0123	including yeast histone deacetylase and acetoin utilization protein
B3921_RS04820	COG1960	acyl-CoA dehydrogenase activity
B3921_RS04825	COG0450	alkyl hydroperoxide reductase
B3921_RS04840	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
B3921_RS04845	COG4208	sulfate ABC transporter
B3921_RS04850	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
B3921_RS04855	COG0175	sulfate reduction
B3921_RS04885	COG0335	large ribosomal subunit rRNA binding
B3921_RS04900	COG0667	Aldo Keto reductase
B3921_RS04910	COG2814	Major facilitator Superfamily
B3921_RS04915	COG3161	chorismate lyase activity
B3921_RS04920	COG1187	pseudouridine synthase activity
B3921_RS04930	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B3921_RS04950	COG1999	signal sequence binding
B3921_RS04955	COG0339	signal peptide processing
B3921_RS04960	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
B3921_RS04965	COG4566	intracellular signal transduction
B3921_RS04975	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
B3921_RS04980	COG0508	dehydrogenase complex catalyzes the overall conversion of
B3921_RS04985	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B3921_RS04990	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
B3921_RS05000	COG1385	rRNA (uridine-N3-)-methyltransferase activity
B3921_RS05005	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
B3921_RS05010	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
B3921_RS05015	COG0126	phosphoglycerate kinase activity
B3921_RS05020	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
B3921_RS05025	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
B3921_RS05040	COG0625	glutathione transferase activity
B3921_RS05070	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
B3921_RS05080	COG0521	Mo-molybdopterin cofactor biosynthetic process
B3921_RS05090	COG0739	heme binding
B3921_RS05100	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
B3921_RS05135	COG0745	RESPONSE REGULATOR receiver
B3921_RS05150	COG0840	transmembrane signaling receptor activity
B3921_RS05160	COG2201	protein-glutamate methylesterase activity
B3921_RS05165	COG0745	RESPONSE REGULATOR receiver
B3921_RS05170	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
B3921_RS05195	COG0667	Aldo Keto reductase
B3921_RS05205	COG4535	Mg2 and Co2 transporter CorC
B3921_RS05210	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
B3921_RS05215	COG1702	phosphate starvation-inducible protein PhoH
B3921_RS05220	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B3921_RS05235	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B3921_RS05240	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B3921_RS05245	COG1862	Preprotein translocase
B3921_RS05250	COG0343	queuine tRNA-ribosyltransferase activity
B3921_RS05255	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
B3921_RS05260	COG2027	D-alanyl-D-alanine carboxypeptidase
B3921_RS05265	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
B3921_RS05275	COG3468	outer membrane autotransporter barrel domain protein
B3921_RS05280	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
B3921_RS05280	COG1648	precorrin-2 dehydrogenase activity
B3921_RS05305	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
B3921_RS05310	COG0741	lytic transglycosylase activity
B3921_RS05315	COG0436	Aminotransferase
B3921_RS05325	COG0280	phosphate acetyltransferase
B3921_RS05325	COG0281	malic enzyme
B3921_RS05335	COG2732	(Barnase) inhibitor
B3921_RS05350	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
B3921_RS05375	COG0248	Ppx GppA phosphatase
B3921_RS05385	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B3921_RS05395	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B3921_RS05400	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
B3921_RS05405	COG1534	Rna-binding protein
B3921_RS05430	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B3921_RS05445	COG1295	ribonuclease BN
B3921_RS05455	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
B3921_RS05460	COG0745	RESPONSE REGULATOR receiver
B3921_RS05465	COG2205	protein histidine kinase activity
B3921_RS05500	COG1022	Amp-dependent synthetase and ligase
B3921_RS05515	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
B3921_RS05520	COG1028	Short-chain dehydrogenase reductase Sdr
B3921_RS05525	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
B3921_RS05530	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
B3921_RS05545	COG1136	(ABC) transporter
B3921_RS05550	COG0084	hydrolase, TatD family'
B3921_RS05585	COG0613	PHP domain protein
B3921_RS05600	COG3539	Fimbrial protein
B3921_RS05605	COG0281	malic enzyme
B3921_RS05605	COG0280	phosphate acetyltransferase
B3921_RS05615	COG1522	sequence-specific DNA binding
B3921_RS05620	COG1297	OPT oligopeptide transporter protein
B3921_RS05625	COG1297	OPT oligopeptide transporter protein
B3921_RS05630	COG0567	Dehydrogenase, E1 component
B3921_RS05635	COG0508	dehydrogenase complex catalyzes the overall conversion of
B3921_RS05640	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B3921_RS05645	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
B3921_RS05650	COG1028	Short-chain dehydrogenase reductase Sdr
B3921_RS05655	COG0583	DNA-binding transcription factor activity
B3921_RS05665	COG3181	Tripartite tricarboxylate transporter family receptor
B3921_RS05685	COG0180	Tryptophanyl-tRNA synthetase
B3921_RS05690	COG2183	response to ionizing radiation
B3921_RS05695	COG1199	ATP-dependent helicase activity
B3921_RS05705	COG0564	pseudouridine synthase activity
B3921_RS05715	COG3243	poly(R)-hydroxyalkanoic acid synthase
B3921_RS05720	COG1028	Short-chain dehydrogenase reductase Sdr
B3921_RS05725	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
B3921_RS05740	COG0672	)-iron permease
B3921_RS05780	COG0583	DNA-binding transcription factor activity
B3921_RS05790	COG2814	Major facilitator Superfamily
B3921_RS05805	COG1619	proteins homologs of microcin C7 resistance protein MccF
B3921_RS05820	COG2084	Dehydrogenase
B3921_RS05825	COG3181	Tripartite tricarboxylate transporter family receptor
B3921_RS05850	COG2988	succinylglutamate desuccinylase activity
B3921_RS05880	COG0765	amino acid transport
B3921_RS05885	COG0765	amino acid transport
B3921_RS05890	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B3921_RS05925	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B3921_RS05930	COG1595	DNA-templated transcription, initiation
B3921_RS05940	COG3530	Putative quorum-sensing-regulated virulence factor
B3921_RS05945	COG0494	nUDIX hydrolase
B3921_RS05960	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B3921_RS05965	COG0542	response to heat
B3921_RS05975	COG3468	outer membrane autotransporter barrel domain protein
B3921_RS05980	COG3468	outer membrane autotransporter barrel domain protein
B3921_RS05990	COG5441	Belongs to the UPF0261 family
B3921_RS05995	COG5564	TIM-barrel signal transduction protein
B3921_RS06010	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
B3921_RS06025	COG1477	protein flavinylation
B3921_RS06045	COG1131	(ABC) transporter
B3921_RS06050	COG0842	Transport permease protein
B3921_RS06060	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
B3921_RS06065	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
B3921_RS06065	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
B3921_RS06070	COG1562	ergosterol biosynthetic process
B3921_RS06075	COG1562	ergosterol biosynthetic process
B3921_RS06080	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
B3921_RS06085	COG1028	Short-chain dehydrogenase reductase Sdr
B3921_RS06105	COG2304	oxidoreductase activity
B3921_RS06125	COG0534	Mate efflux family protein
B3921_RS06135	COG0254	rRNA binding
B3921_RS06140	COG3483	tryptophan 2,3-dioxygenase activity
B3921_RS06145	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
B3921_RS06150	COG2003	Belongs to the UPF0758 family
B3921_RS06155	COG1047	Peptidyl-prolyl cis-trans
B3921_RS06160	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
B3921_RS06165	COG0625	glutathione transferase activity
B3921_RS06185	COG0523	cobalamin synthesis protein
B3921_RS06195	COG0583	DNA-binding transcription factor activity
B3921_RS06205	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
B3921_RS06210	COG1187	pseudouridine synthase activity
B3921_RS06215	COG0779	Required for maturation of 30S ribosomal subunits
B3921_RS06220	COG0195	Participates in both transcription termination and antitermination
B3921_RS06220	COG2251	uridine kinase activity
B3921_RS06225	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
B3921_RS06230	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
B3921_RS06235	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
B3921_RS06255	COG1611	Belongs to the LOG family
B3921_RS06270	COG0412	Dienelactone hydrolase
B3921_RS06275	COG1283	sodium-dependent phosphate transmembrane transporter activity
B3921_RS06280	COG1760	l-serine dehydratase
B3921_RS06285	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
B3921_RS06290	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
B3921_RS06300	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
B3921_RS06325	COG2311	Membrane
B3921_RS06335	COG0697	spore germination
B3921_RS06350	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
B3921_RS06370	COG0559	Belongs to the binding-protein-dependent transport system permease family
B3921_RS06385	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
B3921_RS06395	COG1653	transport
B3921_RS06400	COG1175	transmembrane transport
B3921_RS06405	COG0395	ABC-type sugar transport system, permease component
B3921_RS06410	COG3842	ATPase activity
B3921_RS06435	COG2363	Small membrane protein
B3921_RS06450	COG1464	Belongs to the NlpA lipoprotein family
B3921_RS06460	COG0688	phosphatidylethanolamine metabolic process
B3921_RS06475	COG0095	Lipoate-protein ligase
B3921_RS06490	COG0625	glutathione transferase activity
B3921_RS06495	COG0386	Belongs to the glutathione peroxidase family
B3921_RS06515	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B3921_RS06545	COG2259	Doxx family
B3921_RS06560	COG0667	Aldo Keto reductase
B3921_RS06590	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
B3921_RS06605	COG1640	4-alpha-glucanotransferase
B3921_RS06615	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
B3921_RS06625	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
B3921_RS06665	COG0392	lysyltransferase activity
B3921_RS06680	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B3921_RS06685	COG3568	Endonuclease Exonuclease Phosphatase
B3921_RS06690	COG1695	Transcriptional regulator
B3921_RS06710	COG0583	DNA-binding transcription factor activity
B3921_RS06725	COG1802	Transcriptional regulator
B3921_RS06735	COG3181	Tripartite tricarboxylate transporter family receptor
B3921_RS06745	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B3921_RS06760	COG0066	3-isopropylmalate dehydratase activity
B3921_RS06770	COG3181	Tripartite tricarboxylate transporter family receptor
B3921_RS06775	COG4948	Mandelate Racemase Muconate Lactonizing
B3921_RS06790	COG1126	abc transporter atp-binding protein
B3921_RS06795	COG0765	amino acid transport
B3921_RS06800	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B3921_RS06840	COG1815	bacterial-type flagellum-dependent cell motility
B3921_RS06845	COG1558	bacterial-type flagellum-dependent cell motility
B3921_RS06855	COG1749	Flagellar hook protein flgE
B3921_RS06870	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
B3921_RS06875	COG1706	bacterial-type flagellum-dependent cell motility
B3921_RS06885	COG1256	bacterial-type flagellum assembly
B3921_RS06895	COG0840	transmembrane signaling receptor activity
B3921_RS06900	COG0840	transmembrane signaling receptor activity
B3921_RS06905	COG0840	transmembrane signaling receptor activity
B3921_RS06925	COG1338	Plays a role in the flagellum-specific transport system
B3921_RS06945	COG1580	Controls the rotational direction of flagella during chemotaxis
B3921_RS06970	COG1157	protein secretion by the type III secretion system
B3921_RS06980	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
B3921_RS06990	COG1677	Flagellar hook-basal body complex protein FliE
B3921_RS07000	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
B3921_RS07035	COG0285	dihydrofolate synthase activity
B3921_RS07065	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
B3921_RS07070	COG0024	Methionine aminopeptidase
B3921_RS07075	COG0052	Belongs to the universal ribosomal protein uS2 family
B3921_RS07080	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
B3921_RS07085	COG0528	UMP kinase activity
B3921_RS07090	COG0233	cytoplasmic translational termination
B3921_RS07095	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
B3921_RS07105	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
B3921_RS07110	COG0750	zinc metalloprotease
B3921_RS07115	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B3921_RS07120	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
B3921_RS07125	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B3921_RS07130	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
B3921_RS07140	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B3921_RS07145	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
B3921_RS07150	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B3921_RS07155	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
B3921_RS07165	COG0518	GMP synthase (glutamine-hydrolyzing) activity
B3921_RS07165	COG0519	Catalyzes the synthesis of GMP from XMP
B3921_RS07180	COG0330	HflC and HflK could
B3921_RS07185	COG3706	GGDEF domain
B3921_RS07190	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
B3921_RS07200	COG2867	negative regulation of translational initiation
B3921_RS07210	COG1960	acyl-CoA dehydrogenase activity
B3921_RS07215	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
B3921_RS07245	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
B3921_RS07250	COG0505	Belongs to the CarA family
B3921_RS07255	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B3921_RS07265	COG0406	alpha-ribazole phosphatase activity
B3921_RS07275	COG3842	ATPase activity
B3921_RS07295	COG5001	Diguanylate cyclase
B3921_RS07300	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
B3921_RS07310	COG1763	Mo-molybdopterin cofactor biosynthetic process
B3921_RS07315	COG0303	'Molybdopterin
B3921_RS07320	COG0746	molybdenum cofactor guanylyltransferase activity
B3921_RS07325	COG0489	protein tyrosine kinase activity
B3921_RS07355	COG3383	formate dehydrogenase (NAD+) activity
B3921_RS07355	COG0243	molybdopterin cofactor binding
B3921_RS07360	COG0437	4 iron, 4 sulfur cluster binding
B3921_RS07390	COG1122	ATPase activity
B3921_RS07400	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
B3921_RS07405	COG0066	3-isopropylmalate dehydratase activity
B3921_RS07410	COG0473	3-isopropylmalate dehydrogenase activity
B3921_RS07415	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
B3921_RS07425	COG0101	tRNA pseudouridine synthase activity
B3921_RS07430	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
B3921_RS07445	COG0135	phosphoribosylanthranilate isomerase activity
B3921_RS07460	COG3022	response to hydroperoxide
B3921_RS07470	COG1289	transmembrane transporter activity
B3921_RS07490	COG0635	Involved in the biosynthesis of porphyrin-containing compound
B3921_RS07500	COG2197	response regulator
B3921_RS07505	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
B3921_RS07510	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
B3921_RS07515	COG0189	ligase activity
B3921_RS07525	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
B3921_RS07530	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B3921_RS07540	COG2423	ornithine cyclodeaminase activity
B3921_RS07550	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B3921_RS07555	COG0765	amino acid transport
B3921_RS07560	COG0765	amino acid transport
B3921_RS07565	COG1126	abc transporter atp-binding protein
B3921_RS07620	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
B3921_RS07630	COG2944	sequence-specific DNA binding
B3921_RS07635	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
B3921_RS07640	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
B3921_RS07645	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
B3921_RS07650	COG0009	L-threonylcarbamoyladenylate synthase
B3921_RS07655	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B3921_RS07660	COG1414	Transcriptional regulator
B3921_RS07675	COG0765	amino acid transport
B3921_RS07680	COG1126	abc transporter atp-binding protein
B3921_RS07685	COG0028	Belongs to the TPP enzyme family
B3921_RS07700	COG0028	Belongs to the TPP enzyme family
B3921_RS07705	COG0583	DNA-binding transcription factor activity
B3921_RS07710	COG4974	Belongs to the 'phage' integrase family
B3921_RS07715	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
B3921_RS07720	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
B3921_RS07735	COG1686	Belongs to the peptidase S11 family
B3921_RS07745	COG2814	Major facilitator Superfamily
B3921_RS07755	COG1074	ATP-dependent DNA helicase activity
B3921_RS07760	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
B3921_RS07765	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
B3921_RS07770	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
B3921_RS07790	COG2321	neutral zinc metallopeptidase
B3921_RS07795	COG0009	L-threonylcarbamoyladenylate synthase
B3921_RS07835	COG3360	Dodecin
B3921_RS07840	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
B3921_RS07845	COG2850	peptidyl-arginine hydroxylation
B3921_RS07850	COG3539	Fimbrial protein
B3921_RS07855	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
B3921_RS07860	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B3921_RS07865	COG1994	Peptidase M50
B3921_RS07875	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B3921_RS07880	COG0765	amino acid transport
B3921_RS07885	COG1126	abc transporter atp-binding protein
B3921_RS07890	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B3921_RS07895	COG1758	RNA polymerase activity
B3921_RS07900	COG0194	GDP metabolic process
B3921_RS07905	COG3258	Cytochrome c
B3921_RS07910	COG2863	cytochrome
B3921_RS07915	COG1028	Short-chain dehydrogenase reductase Sdr
B3921_RS07920	COG0791	NLP P60 protein
B3921_RS07925	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
B3921_RS07945	COG1561	YicC-like family, N-terminal region
B3921_RS07950	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
B3921_RS07965	COG2200	EAL domain
B3921_RS07965	COG2199	diguanylate cyclase activity
B3921_RS07970	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
B3921_RS07985	COG0635	Involved in the biosynthesis of porphyrin-containing compound
B3921_RS07990	COG0174	glutamine synthetase
B3921_RS08000	COG2204	response regulator
B3921_RS08005	COG0583	DNA-binding transcription factor activity
B3921_RS08010	COG1741	Belongs to the pirin family
B3921_RS08015	COG1741	Belongs to the pirin family
B3921_RS08025	COG3842	ATPase activity
B3921_RS08030	COG1178	ABC-type Fe3 transport system permease component
B3921_RS08035	COG1840	ABC-type Fe3 transport system, periplasmic component
B3921_RS08045	COG0583	DNA-binding transcription factor activity
B3921_RS08055	COG0656	L-ascorbic acid biosynthetic process
B3921_RS08070	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
B3921_RS08075	COG0583	DNA-binding transcription factor activity
B3921_RS08090	COG0783	Belongs to the Dps family
B3921_RS08125	COG0438	transferase activity, transferring glycosyl groups
B3921_RS08140	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
B3921_RS08165	COG0300	oxidoreductase activity
B3921_RS08210	COG0861	Integral membrane protein TerC family
B3921_RS08215	COG1028	Short-chain dehydrogenase reductase Sdr
B3921_RS08235	COG0714	Associated with various cellular activities
B3921_RS08265	COG3119	arylsulfatase activity
B3921_RS08290	COG2197	response regulator
B3921_RS08300	COG2944	sequence-specific DNA binding
B3921_RS08305	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
B3921_RS08310	COG0625	glutathione transferase activity
B3921_RS08340	COG0179	Fumarylacetoacetate (FAA) hydrolase
B3921_RS08345	COG1028	Short-chain dehydrogenase reductase Sdr
B3921_RS08395	COG0431	NADPH-dependent FMN reductase
B3921_RS08425	COG1028	Short-chain dehydrogenase reductase Sdr
B3921_RS08430	COG0583	DNA-binding transcription factor activity
B3921_RS08445	COG3181	Tripartite tricarboxylate transporter family receptor
B3921_RS08450	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
B3921_RS08450	COG2111	Na H antiporter
B3921_RS08455	COG1006	Multisubunit Na H antiporter MnhC subunit
B3921_RS08460	COG0651	ATP synthesis coupled electron transport
B3921_RS08465	COG1863	multisubunit Na H antiporter MnhE subunit
B3921_RS08470	COG2212	antiporter activity
B3921_RS08495	COG0590	tRNA wobble adenosine to inosine editing
B3921_RS08500	COG1619	proteins homologs of microcin C7 resistance protein MccF
B3921_RS08505	COG1024	Enoyl-CoA hydratase
B3921_RS08520	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
B3921_RS08525	COG0488	(ABC) transporter
B3921_RS08560	COG1017	nitric oxide dioxygenase activity
B3921_RS08560	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
B3921_RS08565	COG1959	2 iron, 2 sulfur cluster binding
B3921_RS08570	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B3921_RS08590	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
B3921_RS08595	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
B3921_RS08600	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
B3921_RS08605	COG0084	hydrolase, TatD family'
B3921_RS08620	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B3921_RS08630	COG1126	abc transporter atp-binding protein
B3921_RS08635	COG0010	Belongs to the arginase family
B3921_RS08640	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
B3921_RS08645	COG1012	belongs to the aldehyde dehydrogenase family
B3921_RS08655	COG0028	Belongs to the TPP enzyme family
B3921_RS08665	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
B3921_RS08665	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
B3921_RS08675	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
B3921_RS08690	COG3189	MarR family transcriptional regulator
B3921_RS08715	COG4336	lyase activity
B3921_RS08725	COG2205	protein histidine kinase activity
B3921_RS08725	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B3921_RS08730	COG2197	response regulator
B3921_RS08735	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
B3921_RS08735	COG3210	domain, Protein
B3921_RS08735	COG3064	Membrane
B3921_RS08745	COG3121	Chaperone
B3921_RS08750	COG3188	usher protein
B3921_RS08755	COG3539	Fimbrial protein
B3921_RS08760	COG2831	hemolysin activation secretion protein
B3921_RS08775	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
B3921_RS08800	COG0583	DNA-binding transcription factor activity
B3921_RS08825	COG0668	transmembrane transport
B3921_RS08845	COG0483	inositol monophosphate 1-phosphatase activity
B3921_RS08850	COG1253	flavin adenine dinucleotide binding
B3921_RS08855	COG1968	undecaprenyl-diphosphatase activity
B3921_RS08860	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B3921_RS08875	COG0215	cysteine-tRNA ligase activity
B3921_RS08885	COG0825	malonyl-CoA metabolic process
B3921_RS08895	COG0037	tRNA processing
B3921_RS08900	COG0527	aspartate kinase activity
B3921_RS08925	COG1250	3-hydroxyacyl-CoA dehydrogenase
B3921_RS08930	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
B3921_RS08930	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
B3921_RS08945	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
B3921_RS08950	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
B3921_RS08955	COG1028	Short-chain dehydrogenase reductase Sdr
B3921_RS08965	COG0583	DNA-binding transcription factor activity
B3921_RS08995	COG3842	ATPase activity
B3921_RS09005	COG1902	pentaerythritol trinitrate reductase activity
B3921_RS09005	COG0446	pyridine nucleotide-disulphide oxidoreductase
B3921_RS09010	COG1414	Transcriptional regulator
B3921_RS09015	COG1832	CoA-binding protein
B3921_RS09025	COG0251	oxidation-reduction process
B3921_RS09050	COG1902	pentaerythritol trinitrate reductase activity
B3921_RS09060	COG1215	transferase activity, transferring glycosyl groups
B3921_RS09065	COG1649	PFAM Uncharacterised BCR, COG1649
B3921_RS09065	COG0726	polysaccharide deacetylase
B3921_RS09085	COG1846	Transcriptional regulator
B3921_RS09105	COG0166	Belongs to the GPI family
B3921_RS09110	COG1045	serine acetyltransferase
B3921_RS09120	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
B3921_RS09125	COG0483	inositol monophosphate 1-phosphatase activity
B3921_RS09130	COG1012	belongs to the aldehyde dehydrogenase family
B3921_RS09135	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
B3921_RS09150	COG0210	DNA helicase
B3921_RS09155	COG0598	Magnesium transport protein CorA
B3921_RS09165	COG0747	negative chemotaxis
B3921_RS09170	COG0601	transmembrane transport
B3921_RS09175	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B3921_RS09180	COG4172	Belongs to the ABC transporter superfamily
B3921_RS09185	COG1846	Transcriptional regulator
B3921_RS09235	COG4964	Belongs to the GSP D family
B3921_RS09275	COG2204	response regulator
B3921_RS09290	COG1595	DNA-templated transcription, initiation
B3921_RS09300	COG3474	cytochrome
B3921_RS09305	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
B3921_RS09320	COG3384	dioxygenase
B3921_RS09325	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
B3921_RS09350	COG2885	chlorophyll binding
B3921_RS09385	COG0697	spore germination
B3921_RS09390	COG0730	response to heat
B3921_RS09405	COG0583	DNA-binding transcription factor activity
B3921_RS09410	COG0427	acetyl-CoA hydrolase
B3921_RS09465	COG1250	3-hydroxyacyl-CoA dehydrogenase
B3921_RS09470	COG0154	amidase activity
B3921_RS09480	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
B3921_RS09495	COG0495	leucyl-tRNA aminoacylation
B3921_RS09500	COG2814	Major facilitator Superfamily
B3921_RS09530	COG0267	Belongs to the bacterial ribosomal protein bL33 family
B3921_RS09535	COG0227	Belongs to the bacterial ribosomal protein bL28 family
B3921_RS09540	COG2814	Major facilitator Superfamily
B3921_RS09545	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
B3921_RS09560	COG4176	ABC-type proline glycine betaine transport system permease component
B3921_RS09570	COG1942	4-Oxalocrotonate Tautomerase
B3921_RS09575	COG0183	Belongs to the thiolase family
B3921_RS09585	COG1802	Transcriptional regulator
B3921_RS09595	COG1024	Enoyl-CoA hydratase
B3921_RS09610	COG2032	superoxide dismutase activity
B3921_RS09625	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
B3921_RS09650	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B3921_RS09655	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B3921_RS09665	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
B3921_RS09670	COG0736	holo-[acyl-carrier-protein] synthase activity
B3921_RS09675	COG1472	Belongs to the glycosyl hydrolase 3 family
B3921_RS09680	COG0322	excinuclease ABC activity
B3921_RS09685	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
B3921_RS09700	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
B3921_RS09700	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
B3921_RS09705	COG2224	Isocitrate lyase
B3921_RS09725	COG0559	Belongs to the binding-protein-dependent transport system permease family
B3921_RS09735	COG4638	Rieske (2fe-2S)
B3921_RS09745	COG1024	Enoyl-CoA hydratase
B3921_RS09755	COG0633	Ferredoxin
B3921_RS09760	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B3921_RS09775	COG0183	Belongs to the thiolase family
B3921_RS09785	COG4692	amylo-alpha-1,6-glucosidase activity
B3921_RS09790	COG0583	DNA-binding transcription factor activity
B3921_RS09815	COG2346	COG2346, Truncated hemoglobins
B3921_RS09940	COG2207	Transcriptional regulator
B3921_RS09985	COG1132	(ABC) transporter
B3921_RS10010	COG0659	secondary active sulfate transmembrane transporter activity
B3921_RS10040	COG2169	Transcriptional regulator
B3921_RS10045	COG5507	3-demethylubiquinone-9 3-methyltransferase
B3921_RS10050	COG0384	phenazine biosynthesis protein PhzF
B3921_RS10055	COG0583	DNA-binding transcription factor activity
B3921_RS10060	COG2733	membrane
B3921_RS10075	COG1012	belongs to the aldehyde dehydrogenase family
B3921_RS10080	COG3284	Transcriptional regulator
B3921_RS10100	COG1346	cytolysis
B3921_RS10105	COG1380	Effector of murein hydrolase LrgA
B3921_RS10110	COG4106	trans-aconitate 2-methyltransferase activity
B3921_RS10110	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
B3921_RS10120	COG0156	8-amino-7-oxononanoate synthase activity
B3921_RS10190	COG1131	(ABC) transporter
B3921_RS10195	COG0842	Transport permease protein
B3921_RS10200	COG0628	permease
B3921_RS10230	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
B3921_RS10240	COG0828	Belongs to the bacterial ribosomal protein bS21 family
B3921_RS10245	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
B3921_RS10250	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
B3921_RS10255	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
B3921_RS10260	COG0330	HflC and HflK could
B3921_RS10265	COG0330	HflC and HflK could
B3921_RS10270	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
B3921_RS10275	COG1923	regulation of RNA biosynthetic process
B3921_RS10280	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B3921_RS10285	COG1160	GTP binding
B3921_RS10290	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B3921_RS10295	COG2976	Protein conserved in bacteria
B3921_RS10300	COG0124	histidyl-tRNA synthetase
B3921_RS10305	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
B3921_RS10315	COG0820	rRNA (adenine-C2-)-methyltransferase activity
B3921_RS10320	COG0105	UTP biosynthetic process
B3921_RS10325	COG0525	valine-tRNA ligase activity
B3921_RS10340	COG0642	Histidine kinase
B3921_RS10360	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
B3921_RS10365	COG0336	Belongs to the RNA methyltransferase TrmD family
B3921_RS10370	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
B3921_RS10375	COG0228	four-way junction DNA binding
B3921_RS10385	COG0425	Belongs to the sulfur carrier protein TusA family
B3921_RS10390	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
B3921_RS10435	COG0154	amidase activity
B3921_RS10440	COG4172	Belongs to the ABC transporter superfamily
B3921_RS10445	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B3921_RS10450	COG0601	transmembrane transport
B3921_RS10455	COG0747	negative chemotaxis
B3921_RS10480	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B3921_RS10490	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
B3921_RS10505	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
B3921_RS10510	COG3395	kinase activity
B3921_RS10525	COG1024	Enoyl-CoA hydratase
B3921_RS10545	COG0633	Ferredoxin
B3921_RS10550	COG0443	Heat shock 70 kDa protein
B3921_RS10555	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
B3921_RS10560	COG0316	Belongs to the HesB IscA family
B3921_RS10565	COG0822	iron-sulfur transferase activity
B3921_RS10570	COG1104	cysteine desulfurase activity
B3921_RS10580	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B3921_RS10585	COG0556	nucleotide-excision repair
B3921_RS10595	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
B3921_RS10600	COG3468	outer membrane autotransporter barrel domain protein
B3921_RS10625	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
B3921_RS10640	COG1960	acyl-CoA dehydrogenase activity
B3921_RS10645	COG1028	Short-chain dehydrogenase reductase Sdr
B3921_RS10650	COG0183	Belongs to the thiolase family
B3921_RS10660	COG1024	Enoyl-CoA hydratase
B3921_RS10675	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B3921_RS10680	COG0583	DNA-binding transcription factor activity
B3921_RS10685	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
B3921_RS10690	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
B3921_RS10695	COG0740	serine-type endopeptidase activity
B3921_RS10700	COG0544	peptidyl-prolyl cis-trans isomerase activity
B3921_RS10710	COG1278	Cold shock
B3921_RS10720	COG1278	Cold shock
B3921_RS10755	COG2171	N-acyltransferase activity
B3921_RS10760	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B3921_RS10765	COG2890	protein-(glutamine-N5) methyltransferase activity
B3921_RS10770	COG0488	(ABC) transporter
B3921_RS10775	COG4771	TonB-dependent receptor
B3921_RS10780	COG0210	DNA helicase
B3921_RS10800	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B3921_RS10800	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
B3921_RS10805	COG0196	riboflavin kinase activity
B3921_RS10810	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
B3921_RS10815	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
B3921_RS10820	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
B3921_RS10830	COG1522	sequence-specific DNA binding
B3921_RS10845	COG2951	lytic endotransglycosylase activity
B3921_RS10850	COG2833	Protein of unknown function (DUF455)
B3921_RS10870	COG0189	ligase activity
B3921_RS10870	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
B3921_RS10875	COG1181	Belongs to the D-alanine--D-alanine ligase family
B3921_RS10875	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
B3921_RS10880	COG3237	CsbD-like
B3921_RS10890	COG2823	Periplasmic or secreted lipoprotein
B3921_RS10900	COG4181	ATPase activity
B3921_RS10910	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B3921_RS10915	COG0584	glycerophosphoryl diester phosphodiesterase
B3921_RS10920	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
B3921_RS10930	COG0678	peroxiredoxin activity
B3921_RS10930	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
B3921_RS10940	COG0789	Transcriptional regulator
B3921_RS10945	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B3921_RS10975	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
B3921_RS10980	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
B3921_RS10990	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
B3921_RS10995	COG2252	PERMEase
B3921_RS11005	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B3921_RS11035	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B3921_RS11040	COG2358	TRAP transporter, solute receptor (TAXI family
B3921_RS11070	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B3921_RS11075	COG1366	Belongs to the anti-sigma-factor antagonist family
B3921_RS11080	COG2172	sigma factor antagonist activity
B3921_RS11085	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
B3921_RS11095	COG2770	Histidine kinase
B3921_RS11095	COG2208	phosphoserine phosphatase activity
B3921_RS11120	COG1595	DNA-templated transcription, initiation
B3921_RS11135	COG4792	protein secretion
B3921_RS11140	COG4791	protein targeting
B3921_RS11145	COG4794	Type iii secretion
B3921_RS11150	COG4790	Type iii secretion
B3921_RS11185	COG4669	(LipO)protein
B3921_RS11250	COG4789	Type iii secretion
B3921_RS11280	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B3921_RS11285	COG0840	transmembrane signaling receptor activity
B3921_RS11290	COG2233	PERMEase
B3921_RS11310	COG0492	ferredoxin-NADP+ reductase activity
B3921_RS11315	COG1840	ABC-type Fe3 transport system, periplasmic component
B3921_RS11320	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B3921_RS11325	COG1178	ABC-type Fe3 transport system permease component
B3921_RS11330	COG3842	ATPase activity
B3921_RS11335	COG0583	DNA-binding transcription factor activity
B3921_RS11355	COG0501	Belongs to the peptidase M48B family
B3921_RS11365	COG0697	spore germination
B3921_RS11375	COG1846	Transcriptional regulator
B3921_RS11385	COG1566	PFAM secretion protein HlyD family protein
B3921_RS11390	COG2814	Major facilitator Superfamily
B3921_RS11395	COG0473	3-isopropylmalate dehydrogenase activity
B3921_RS11405	COG0747	negative chemotaxis
B3921_RS11415	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B3921_RS11430	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
B3921_RS11455	COG1012	belongs to the aldehyde dehydrogenase family
B3921_RS11465	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B3921_RS11470	COG1115	amino acid carrier protein
B3921_RS11475	COG0433	COG0433 Predicted ATPase
B3921_RS11480	COG0217	transcriptional regulatory protein
B3921_RS11485	COG0151	Belongs to the GarS family
B3921_RS11490	COG0408	coproporphyrinogen oxidase activity
B3921_RS11495	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
B3921_RS11500	COG0799	negative regulation of ribosome biogenesis
B3921_RS11505	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
B3921_RS11510	COG0424	maF-like protein
B3921_RS11515	COG3468	outer membrane autotransporter barrel domain protein
B3921_RS11555	COG1530	ribonuclease E activity
B3921_RS11560	COG0077	Prephenate dehydratase
B3921_RS11575	COG1132	(ABC) transporter
B3921_RS11580	COG0859	PFAM glycosyl transferase family 9
B3921_RS11610	COG2194	sulfuric ester hydrolase activity
B3921_RS11615	COG0438	transferase activity, transferring glycosyl groups
B3921_RS11620	COG0463	Glycosyl transferase, family 2
B3921_RS11625	COG0726	polysaccharide deacetylase
B3921_RS11630	COG0438	transferase activity, transferring glycosyl groups
B3921_RS11645	COG1643	Atp-dependent helicase
B3921_RS11650	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
B3921_RS11650	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
B3921_RS11655	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
B3921_RS11665	COG0704	Plays a role in the regulation of phosphate uptake
B3921_RS11670	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
B3921_RS11675	COG1960	acyl-CoA dehydrogenase activity
B3921_RS11700	COG1177	transmembrane transport
B3921_RS11705	COG1176	ABC-type spermidine putrescine transport system, permease component I
B3921_RS11710	COG3842	ATPase activity
B3921_RS11715	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
B3921_RS11730	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
B3921_RS11735	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
B3921_RS11745	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
B3921_RS11745	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
B3921_RS11765	COG0372	Belongs to the citrate synthase family
B3921_RS11770	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
B3921_RS11775	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
B3921_RS11780	COG1053	succinate dehydrogenase
B3921_RS11785	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
B3921_RS11790	COG2009	succinate dehydrogenase
B3921_RS11795	COG2188	Transcriptional regulator
B3921_RS11800	COG0039	L-malate dehydrogenase activity
B3921_RS11830	COG1981	membrane
B3921_RS11855	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B3921_RS11865	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
B3921_RS11895	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
B3921_RS11900	COG0148	phosphopyruvate hydratase activity
B3921_RS11910	COG2877	3-deoxy-8-phosphooctulonate synthase activity
B3921_RS11915	COG0504	CTP synthase activity
B3921_RS11940	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B3921_RS11950	COG0747	negative chemotaxis
B3921_RS11955	COG4172	Belongs to the ABC transporter superfamily
B3921_RS11960	COG1446	asparaginase
B3921_RS11990	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
B3921_RS12005	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
B3921_RS12010	COG0697	spore germination
B3921_RS12015	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B3921_RS12025	COG3193	protein, possibly involved in utilization of glycolate and propanediol
B3921_RS12030	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B3921_RS12035	COG0791	NLP P60 protein
B3921_RS12050	COG0583	DNA-binding transcription factor activity
B3921_RS12065	COG0583	DNA-binding transcription factor activity
B3921_RS12075	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
B3921_RS12090	COG0670	Belongs to the BI1 family
B3921_RS12095	COG3181	Tripartite tricarboxylate transporter family receptor
B3921_RS12110	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
B3921_RS12120	COG1381	Involved in DNA repair and RecF pathway recombination
B3921_RS12125	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
B3921_RS12130	COG0571	ribonuclease III activity
B3921_RS12135	COG0681	Belongs to the peptidase S26 family
B3921_RS12140	COG0481	GTPase activity
B3921_RS12145	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B3921_RS12170	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B3921_RS12175	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B3921_RS12190	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B3921_RS12195	COG0416	fatty acid biosynthetic process
B3921_RS12200	COG0333	Belongs to the bacterial ribosomal protein bL32 family
B3921_RS12205	COG1399	metal-binding, possibly nucleic acid-binding protein
B3921_RS12210	COG0424	maF-like protein
B3921_RS12220	COG3023	N-Acetylmuramoyl-L-alanine amidase
B3921_RS12225	COG1289	transmembrane transporter activity
B3921_RS12235	COG3022	response to hydroperoxide
B3921_RS12245	COG1028	Short-chain dehydrogenase reductase Sdr
B3921_RS12260	COG3486	L-lysine 6-monooxygenase (NADPH) activity
B3921_RS12290	COG2814	Major facilitator Superfamily
B3921_RS12310	COG3706	GGDEF domain
B3921_RS12335	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
B3921_RS12340	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
B3921_RS12345	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
B3921_RS12350	COG1674	ftsk spoiiie
B3921_RS12355	COG0492	ferredoxin-NADP+ reductase activity
B3921_RS12360	COG1193	negative regulation of DNA recombination
B3921_RS12380	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B3921_RS12390	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
B3921_RS12395	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
B3921_RS12400	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
B3921_RS12405	COG2205	protein histidine kinase activity
B3921_RS12410	COG0745	RESPONSE REGULATOR receiver
B3921_RS12455	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B3921_RS12475	COG0612	Peptidase, M16
B3921_RS12485	COG0443	Heat shock 70 kDa protein
B3921_RS12495	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
B3921_RS12505	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
B3921_RS12510	COG1420	regulation of RNA biosynthetic process
B3921_RS12515	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
B3921_RS12520	COG0497	DNA recombination
B3921_RS12525	COG0735	belongs to the Fur family
B3921_RS12530	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B3921_RS12535	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
B3921_RS12540	COG0812	UDP-N-acetylmuramate dehydrogenase activity
B3921_RS12575	COG0404	The glycine cleavage system catalyzes the degradation of glycine
B3921_RS12575	COG0446	pyridine nucleotide-disulphide oxidoreductase
B3921_RS12580	COG4311	Sarcosine oxidase, delta subunit
B3921_RS12585	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B3921_RS12595	COG0583	DNA-binding transcription factor activity
B3921_RS12605	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
B3921_RS12635	COG4964	Belongs to the GSP D family
B3921_RS12695	COG0181	hydroxymethylbilane synthase activity
B3921_RS12700	COG0861	Integral membrane protein TerC family
B3921_RS12705	COG0861	Integral membrane protein TerC family
B3921_RS12710	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
B3921_RS12715	COG0045	succinate-CoA ligase (ADP-forming) activity
B3921_RS12725	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
B3921_RS12735	COG2137	regulation of response to DNA damage stimulus
B3921_RS12740	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
B3921_RS12760	COG1250	3-hydroxyacyl-CoA dehydrogenase
B3921_RS12760	COG1024	Enoyl-CoA hydratase
B3921_RS12765	COG3842	ATPase activity
B3921_RS12780	COG1028	Short-chain dehydrogenase reductase Sdr
B3921_RS12800	COG0583	DNA-binding transcription factor activity
B3921_RS12805	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B3921_RS12815	COG2974	May be involved in recombination
B3921_RS12820	COG0540	Belongs to the ATCase OTCase family
B3921_RS12890	COG0776	regulation of translation
B3921_RS12895	COG0072	phenylalanine-tRNA ligase activity
B3921_RS12895	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B3921_RS12900	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
B3921_RS12905	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
B3921_RS12910	COG0291	Belongs to the bacterial ribosomal protein bL35 family
B3921_RS12920	COG0756	dUTP diphosphatase activity
B3921_RS12930	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B3921_RS12945	COG0500	methyltransferase
B3921_RS12955	COG0586	Pfam SNARE associated Golgi protein
B3921_RS12980	COG1609	Transcriptional regulator
B3921_RS12985	COG4172	Belongs to the ABC transporter superfamily
B3921_RS12990	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B3921_RS12995	COG0601	transmembrane transport
B3921_RS13000	COG0747	negative chemotaxis
B3921_RS13015	COG1280	lysine exporter protein (LysE YggA)
B3921_RS13030	COG2814	Major facilitator Superfamily
B3921_RS13060	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
B3921_RS13075	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
B3921_RS13110	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B3921_RS13115	COG1116	anion transmembrane transporter activity
B3921_RS13125	COG1228	amidohydrolase
B3921_RS13140	COG0477	Major facilitator Superfamily
B3921_RS13150	COG3550	peptidyl-serine autophosphorylation
B3921_RS13160	COG0518	GMP synthase (glutamine-hydrolyzing) activity
B3921_RS13160	COG0519	Catalyzes the synthesis of GMP from XMP
B3921_RS13185	COG2197	response regulator
B3921_RS13210	COG0420	3'-5' exonuclease activity
B3921_RS13215	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B3921_RS13245	COG0395	ABC-type sugar transport system, permease component
B3921_RS13255	COG3842	ATPase activity
B3921_RS13285	COG3181	Tripartite tricarboxylate transporter family receptor
B3921_RS13320	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B3921_RS13345	COG0602	queuosine metabolic process
B3921_RS13350	COG0720	synthase
B3921_RS13355	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
B3921_RS13360	COG0235	Class ii aldolase
B3921_RS13385	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
B3921_RS13385	COG3210	domain, Protein
B3921_RS13385	COG3064	Membrane
B3921_RS13390	COG0047	phosphoribosylformylglycinamidine synthase activity
B3921_RS13390	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B3921_RS13395	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
B3921_RS13400	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
B3921_RS13400	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
B3921_RS13405	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
B3921_RS13425	COG3539	Fimbrial protein
B3921_RS13435	COG2050	protein possibly involved in aromatic compounds catabolism
B3921_RS13440	COG1024	Enoyl-CoA hydratase
B3921_RS13445	COG1012	belongs to the aldehyde dehydrogenase family
B3921_RS13455	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
B3921_RS13460	COG2151	metal-sulfur cluster biosynthetic enzyme
B3921_RS13465	COG3396	Phenylacetate-CoA oxygenase
B3921_RS13470	COG3460	Phenylacetate-CoA oxygenase
B3921_RS13475	COG3396	Phenylacetate-CoA oxygenase
B3921_RS13480	COG3327	negative regulation of DNA-templated transcription, initiation
B3921_RS13490	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
B3921_RS13495	COG0501	Belongs to the peptidase M48B family
B3921_RS13500	COG1162	GTPase activity
B3921_RS13505	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B3921_RS13510	COG0601	transmembrane transport
B3921_RS13515	COG0747	negative chemotaxis
B3921_RS13560	COG0668	transmembrane transport
B3921_RS13565	COG0165	Argininosuccinate lyase
B3921_RS13585	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
B3921_RS13590	COG0303	'Molybdopterin
B3921_RS13595	COG0521	Mo-molybdopterin cofactor biosynthetic process
B3921_RS13610	COG0315	cyclic pyranopterin monophosphate synthase activity
B3921_RS13620	COG0412	Dienelactone hydrolase
B3921_RS13630	COG0678	peroxiredoxin activity
B3921_RS13640	COG0697	spore germination
B3921_RS13645	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
B3921_RS13670	COG0789	Transcriptional regulator
B3921_RS13690	COG1028	Short-chain dehydrogenase reductase Sdr
B3921_RS13700	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
B3921_RS13705	COG1845	cytochrome c oxidase, subunit III
B3921_RS13710	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
B3921_RS13720	COG0477	Major facilitator Superfamily
B3921_RS13750	COG3468	outer membrane autotransporter barrel domain protein
B3921_RS13760	COG1309	transcriptional regulator
B3921_RS13765	COG2271	Major facilitator Superfamily
B3921_RS13800	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
B3921_RS13800	COG0506	proline dehydrogenase activity
B3921_RS13800	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
B3921_RS13810	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
B3921_RS13810	COG3008	intermembrane lipid transfer
B3921_RS13815	COG2995	paraquat-inducible protein a
B3921_RS13820	COG0542	response to heat
B3921_RS13825	COG4953	penicillin-binding protein 1C
B3921_RS13835	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
B3921_RS13840	COG1278	Cold shock
B3921_RS13850	COG0183	Belongs to the thiolase family
B3921_RS13855	COG0038	chloride channel
B3921_RS13860	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
B3921_RS13865	COG1570	exodeoxyribonuclease VII activity
B3921_RS13875	COG0811	peptide transport
B3921_RS13880	COG0848	biopolymer transport protein
B3921_RS13885	COG1663	tetraacyldisaccharide 4'-kinase activity
B3921_RS13890	COG2835	tetraacyldisaccharide 4'-kinase activity
B3921_RS13895	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
B3921_RS13900	COG0563	adenylate kinase activity
B3921_RS13910	COG0728	peptidoglycan biosynthetic process
B3921_RS13920	COG0268	Binds directly to 16S ribosomal RNA
B3921_RS13950	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
B3921_RS13975	COG0436	Aminotransferase
B3921_RS13980	COG3737	Protein of unknown function (DUF498/DUF598)
B3921_RS13985	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
B3921_RS13990	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
B3921_RS13995	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
B3921_RS14005	COG0305	Participates in initiation and elongation during chromosome replication
B3921_RS14015	COG0359	binds to the 23S rRNA
B3921_RS14020	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
B3921_RS14025	COG2965	DNA replication, synthesis of RNA primer
B3921_RS14030	COG0360	Binds together with S18 to 16S ribosomal RNA
B3921_RS14035	COG1469	GTP cyclohydrolase I activity
B3921_RS14040	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
B3921_RS14045	COG0142	geranyltranstransferase activity
B3921_RS14050	COG1722	exodeoxyribonuclease VII activity
B3921_RS14060	COG3181	Tripartite tricarboxylate transporter family receptor
B3921_RS14080	COG2239	Acts as a magnesium transporter
B3921_RS14090	COG2855	membrane
B3921_RS14100	COG1473	amidohydrolase
B3921_RS14105	COG0318	PFAM AMP-dependent synthetase and ligase
B3921_RS14125	COG1501	Belongs to the glycosyl hydrolase 31 family
B3921_RS14130	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
B3921_RS14135	COG2011	ABC-type metal ion transport system permease component
B3921_RS14155	COG1454	alcohol dehydrogenase
B3921_RS14180	COG2186	Transcriptional regulator
B3921_RS14185	COG3181	Tripartite tricarboxylate transporter family receptor
B3921_RS14205	COG1175	transmembrane transport
B3921_RS14210	COG0395	ABC-type sugar transport system, permease component
B3921_RS14215	COG3842	ATPase activity
B3921_RS14220	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B3921_RS14230	COG1653	transport
B3921_RS14250	COG2818	Glycosylase
B3921_RS14255	COG2982	Protein involved in outer membrane biogenesis
B3921_RS14265	COG1309	transcriptional regulator
B3921_RS14270	COG1028	Short-chain dehydrogenase reductase Sdr
B3921_RS14310	COG0583	DNA-binding transcription factor activity
B3921_RS14315	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
B3921_RS14320	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
B3921_RS14335	COG1028	Short-chain dehydrogenase reductase Sdr
B3921_RS14340	COG0477	Major facilitator Superfamily
B3921_RS14350	COG0583	DNA-binding transcription factor activity
B3921_RS14355	COG1448	Aminotransferase
B3921_RS14360	COG1418	mRNA catabolic process
B3921_RS14385	COG1063	alcohol dehydrogenase
B3921_RS14405	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B3921_RS14415	COG0318	PFAM AMP-dependent synthetase and ligase
B3921_RS14425	COG1522	sequence-specific DNA binding
B3921_RS14430	COG3181	Tripartite tricarboxylate transporter family receptor
B3921_RS14435	COG0307	riboflavin synthase, alpha
B3921_RS14440	COG0154	amidase activity
B3921_RS14460	COG2807	transmembrane transport
B3921_RS14465	COG0590	tRNA wobble adenosine to inosine editing
B3921_RS14475	COG0583	DNA-binding transcription factor activity
B3921_RS14490	COG1902	pentaerythritol trinitrate reductase activity
B3921_RS14510	COG0559	Belongs to the binding-protein-dependent transport system permease family
B3921_RS14515	COG0251	oxidation-reduction process
B3921_RS14520	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B3921_RS14530	COG1414	Transcriptional regulator
B3921_RS14535	COG1028	Short-chain dehydrogenase reductase Sdr
B3921_RS14550	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B3921_RS14565	COG1024	Enoyl-CoA hydratase
B3921_RS14570	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B3921_RS14575	COG0154	amidase activity
B3921_RS14615	COG3909	cytochrome
B3921_RS14620	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
B3921_RS14625	COG0625	glutathione transferase activity
B3921_RS14630	COG0730	response to heat
B3921_RS14635	COG0482	sulfurtransferase activity
B3921_RS14640	COG0583	DNA-binding transcription factor activity
B3921_RS14675	COG2819	hydrolase of the alpha beta superfamily
B3921_RS14680	COG0247	lactate metabolic process
B3921_RS14685	COG0277	FAD linked oxidase domain protein
B3921_RS14690	COG0277	FAD linked oxidase domain protein
B3921_RS14695	COG0277	FAD linked oxidase domain protein
B3921_RS14700	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
B3921_RS14700	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
B3921_RS14700	COG3064	Membrane
B3921_RS14700	COG3210	domain, Protein
B3921_RS14700	COG3064	Membrane
B3921_RS14700	COG3210	domain, Protein
B3921_RS14705	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
B3921_RS14710	COG0312	modulator of DNA gyrase
B3921_RS14745	COG1666	GTP binding
B3921_RS14790	COG3220	belongs to the UPF0276 family
B3921_RS14810	COG0640	Transcriptional regulator
B3921_RS14815	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
B3921_RS14820	COG1845	cytochrome c oxidase, subunit III
B3921_RS14825	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
B3921_RS14835	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
B3921_RS14870	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B3921_RS14875	COG0583	DNA-binding transcription factor activity
B3921_RS14905	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B3921_RS14905	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B3921_RS14920	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
B3921_RS14925	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
B3921_RS14935	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
B3921_RS14950	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
B3921_RS14955	COG0316	Belongs to the HesB IscA family
B3921_RS14965	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
B3921_RS14970	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
B3921_RS14975	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
B3921_RS14980	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
B3921_RS14985	COG0312	modulator of DNA gyrase
B3921_RS14990	COG3028	Belongs to the UPF0307 family
B3921_RS15005	COG1116	anion transmembrane transporter activity
B3921_RS15010	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B3921_RS15015	COG1335	isochorismatase
B3921_RS15020	COG0346	lactoylglutathione lyase activity
B3921_RS15025	COG0513	Belongs to the DEAD box helicase family
B3921_RS15030	COG3069	C4-dicarboxylate transmembrane transporter activity
B3921_RS15035	COG1802	Transcriptional regulator
B3921_RS15045	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B3921_RS15045	COG1042	CoA-binding domain protein
B3921_RS15045	COG0045	succinate-CoA ligase (ADP-forming) activity
B3921_RS15050	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B3921_RS15065	COG1522	sequence-specific DNA binding
B3921_RS15100	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B3921_RS15105	COG1696	Membrane protein involved in D-alanine export
B3921_RS15130	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B3921_RS15140	COG2264	protein methyltransferase activity
B3921_RS15145	COG0439	Biotin carboxylase
B3921_RS15150	COG0511	ligase activity, forming carbon-carbon bonds
B3921_RS15155	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
B3921_RS15160	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B3921_RS15165	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
B3921_RS15170	COG3150	esterase
B3921_RS15175	COG0557	exoribonuclease II activity
B3921_RS15185	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
B3921_RS15205	COG1522	sequence-specific DNA binding
B3921_RS15210	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B3921_RS15215	COG1028	Short-chain dehydrogenase reductase Sdr
B3921_RS15235	COG0653	protein targeting
B3921_RS15240	COG0739	heme binding
B3921_RS15250	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
B3921_RS15255	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
B3921_RS15265	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
B3921_RS15270	COG1181	Belongs to the D-alanine--D-alanine ligase family
B3921_RS15275	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
B3921_RS15280	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B3921_RS15290	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
B3921_RS15295	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B3921_RS15300	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
B3921_RS15310	COG3116	cell division
B3921_RS15315	COG0275	rRNA processing
B3921_RS15320	COG2001	Belongs to the MraZ family
B3921_RS15325	COG0488	(ABC) transporter
B3921_RS15330	COG0418	dihydroorotase activity
B3921_RS15335	COG1473	amidohydrolase
B3921_RS15385	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B3921_RS15390	COG4654	Cytochrome c, class I
B3921_RS15395	COG0129	dihydroxy-acid dehydratase activity
B3921_RS15400	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
B3921_RS15450	COG2084	Dehydrogenase
B3921_RS15455	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
B3921_RS15470	COG2096	Adenosyltransferase
B3921_RS15480	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
B3921_RS15485	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
B3921_RS15495	COG0523	cobalamin synthesis protein
B3921_RS15500	COG0735	belongs to the Fur family
B3921_RS15520	COG0803	Belongs to the bacterial solute-binding protein 9 family
B3921_RS15530	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
B3921_RS15540	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
B3921_RS15550	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
B3921_RS15555	COG1560	Kdo2-lipid A biosynthetic process
B3921_RS15565	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
B3921_RS15580	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
B3921_RS15585	COG1950	PFAM Membrane protein of
B3921_RS15600	COG0583	DNA-binding transcription factor activity
B3921_RS15610	COG0477	Major facilitator Superfamily
B3921_RS15625	COG0617	tRNA 3'-terminal CCA addition
B3921_RS15635	COG0513	Belongs to the DEAD box helicase family
B3921_RS15640	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
B3921_RS15650	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B3921_RS15655	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
B3921_RS15715	COG1280	lysine exporter protein (LysE YggA)
B3921_RS15730	COG0405	Gamma-glutamyltransferase
B3921_RS15740	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B3921_RS15765	COG1309	transcriptional regulator
B3921_RS15780	COG0745	RESPONSE REGULATOR receiver
B3921_RS15825	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
B3921_RS15845	COG0582	viral genome integration into host DNA
B3921_RS15850	COG0012	GTP binding
B3921_RS15860	COG0193	aminoacyl-tRNA hydrolase activity
B3921_RS15865	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
B3921_RS15870	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
B3921_RS15880	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
B3921_RS15885	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
B3921_RS15895	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
B3921_RS15920	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
B3921_RS15930	COG1368	sulfuric ester hydrolase activity
B3921_RS15935	COG0642	Histidine kinase
B3921_RS15940	COG0745	RESPONSE REGULATOR receiver
B3921_RS15945	COG0277	FAD linked oxidase domain protein
B3921_RS15960	COG0166	Belongs to the GPI family
B3921_RS15965	COG0438	transferase activity, transferring glycosyl groups
B3921_RS15970	COG0438	transferase activity, transferring glycosyl groups
B3921_RS15985	COG0438	transferase activity, transferring glycosyl groups
B3921_RS16000	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
B3921_RS16005	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B3921_RS16010	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
B3921_RS16020	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
B3921_RS16030	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B3921_RS16035	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B3921_RS16045	COG0747	negative chemotaxis
B3921_RS16050	COG0601	transmembrane transport
B3921_RS16055	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B3921_RS16075	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
B3921_RS16080	COG0830	nickel cation binding
B3921_RS16090	COG0804	urea catabolic process
B3921_RS16095	COG0832	Belongs to the urease beta subunit family
B3921_RS16105	COG0831	urea catabolic process
B3921_RS16110	COG0829	nickel cation binding
B3921_RS16120	COG0633	Ferredoxin
B3921_RS16135	COG2188	Transcriptional regulator
B3921_RS16160	COG2719	SpoVR family
B3921_RS16165	COG2718	Belongs to the UPF0229 family
B3921_RS16180	COG1028	Short-chain dehydrogenase reductase Sdr
B3921_RS16185	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B3921_RS16200	COG1960	acyl-CoA dehydrogenase activity
B3921_RS16245	COG0183	Belongs to the thiolase family
B3921_RS16250	COG2030	dehydratase
B3921_RS16295	COG0328	RNA-DNA hybrid ribonuclease activity
B3921_RS16300	COG2226	methyltransferase
B3921_RS16305	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B3921_RS16310	COG1388	LysM domain
B3921_RS16310	COG0741	lytic transglycosylase activity
B3921_RS16330	COG2979	Protein of unknown function (DUF533)
B3921_RS16365	COG1271	oxidase subunit
B3921_RS16370	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B3921_RS16375	COG0850	regulation of cytokinetic process
B3921_RS16380	COG2894	cell division
B3921_RS16385	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
B3921_RS16405	COG0488	(ABC) transporter
B3921_RS16415	COG0601	transmembrane transport
B3921_RS16425	COG1215	transferase activity, transferring glycosyl groups
B3921_RS16440	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
B3921_RS16450	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B3921_RS16470	COG0318	PFAM AMP-dependent synthetase and ligase
B3921_RS16475	COG2188	Transcriptional regulator
B3921_RS16480	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
B3921_RS16485	COG2814	Major facilitator Superfamily
B3921_RS16495	COG0259	pyridoxamine-phosphate oxidase activity
B3921_RS16500	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
B3921_RS16515	COG0583	DNA-binding transcription factor activity
B3921_RS16520	COG1960	acyl-CoA dehydrogenase activity
B3921_RS16545	COG0134	indole-3-glycerol-phosphate synthase activity
B3921_RS16550	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
B3921_RS16555	COG0512	Glutamine amidotransferase of anthranilate synthase
B3921_RS16565	COG0546	phosphoglycolate phosphatase activity
B3921_RS16570	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
B3921_RS16575	COG2967	ApaG domain
B3921_RS16580	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
B3921_RS16585	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B3921_RS16590	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
B3921_RS16595	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B3921_RS16605	COG0037	tRNA processing
B3921_RS16615	COG3634	alkyl hydroperoxide reductase activity
B3921_RS16620	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B3921_RS16625	COG1024	Enoyl-CoA hydratase
B3921_RS16650	COG0356	it plays a direct role in the translocation of protons across the membrane
B3921_RS16660	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
B3921_RS16665	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B3921_RS16670	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
B3921_RS16675	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
B3921_RS16680	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
B3921_RS16685	COG0355	proton-transporting ATP synthase activity, rotational mechanism
B3921_RS16695	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
B3921_RS16700	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
B3921_RS16705	COG0210	DNA helicase
B3921_RS16715	COG2195	Cleaves the N-terminal amino acid of tripeptides
B3921_RS16725	COG4172	Belongs to the ABC transporter superfamily
B3921_RS16730	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B3921_RS16735	COG0601	transmembrane transport
B3921_RS16755	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
B3921_RS16760	COG1024	Enoyl-CoA hydratase
B3921_RS16765	COG1024	Enoyl-CoA hydratase
B3921_RS16790	COG1250	3-hydroxyacyl-CoA dehydrogenase
B3921_RS16820	COG2132	Multicopper oxidase
B3921_RS16830	COG1250	3-hydroxyacyl-CoA dehydrogenase
B3921_RS16830	COG1024	Enoyl-CoA hydratase
B3921_RS16845	COG1414	Transcriptional regulator
B3921_RS16855	COG0154	amidase activity
B3921_RS16885	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B3921_RS16890	COG3568	Endonuclease Exonuclease Phosphatase
B3921_RS16895	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
B3921_RS16925	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
B3921_RS16935	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
B3921_RS16950	COG1137	ATPase activity
B3921_RS16965	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
B3921_RS16970	COG1529	Aldehyde oxidase and xanthine dehydrogenase
B3921_RS16970	COG2010	Cytochrome c
B3921_RS16980	COG1660	Displays ATPase and GTPase activities
B3921_RS16985	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
B3921_RS17025	COG3181	Tripartite tricarboxylate transporter family receptor
B3921_RS17035	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
B3921_RS17040	COG2890	protein-(glutamine-N5) methyltransferase activity
B3921_RS17045	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
B3921_RS17050	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
B3921_RS17095	COG1960	acyl-CoA dehydrogenase activity
B3921_RS17105	COG0183	Belongs to the thiolase family
B3921_RS17110	COG1522	sequence-specific DNA binding
B3921_RS17115	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B3921_RS17135	COG1024	Enoyl-CoA hydratase
B3921_RS17150	COG0604	alcohol dehydrogenase
B3921_RS17170	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B3921_RS17180	COG1960	acyl-CoA dehydrogenase activity
B3921_RS17185	COG1960	acyl-CoA dehydrogenase activity
B3921_RS17190	COG0277	FAD linked oxidase domain protein
B3921_RS17200	COG3181	Tripartite tricarboxylate transporter family receptor
B3921_RS17220	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B3921_RS17230	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B3921_RS17235	COG3181	Tripartite tricarboxylate transporter family receptor
B3921_RS17240	COG1960	acyl-CoA dehydrogenase activity
B3921_RS17260	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B3921_RS17265	COG1024	Enoyl-CoA hydratase
B3921_RS17270	COG1960	acyl-CoA dehydrogenase activity
B3921_RS17290	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
B3921_RS17295	COG0022	dehydrogenase e1 component
B3921_RS17300	COG1024	Enoyl-CoA hydratase
B3921_RS17305	COG0508	dehydrogenase complex catalyzes the overall conversion of
B3921_RS17325	COG0683	leucine binding
B3921_RS17330	COG0559	Belongs to the binding-protein-dependent transport system permease family
B3921_RS17335	COG0411	ABC transporter
B3921_RS17345	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B3921_RS17360	COG3181	Tripartite tricarboxylate transporter family receptor
B3921_RS17385	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
B3921_RS17390	COG0793	Belongs to the peptidase S41A family
B3921_RS17395	COG4942	peptidase
B3921_RS17400	COG0588	phosphoglycerate mutase activity
B3921_RS17405	COG1054	Belongs to the UPF0176 family
B3921_RS17410	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
B3921_RS17415	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
B3921_RS17420	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
B3921_RS17425	COG3181	Tripartite tricarboxylate transporter family receptor
B3921_RS17440	COG2226	methyltransferase
B3921_RS17445	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
B3921_RS17460	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B3921_RS17465	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
B3921_RS17490	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
B3921_RS17515	COG1335	isochorismatase
B3921_RS17520	COG2309	aminopeptidase activity
B3921_RS17525	COG0596	Alpha beta hydrolase
B3921_RS17530	COG3473	Maleate cis-trans isomerase
B3921_RS17540	COG2068	MobA-Related Protein
B3921_RS17565	COG2204	response regulator
B3921_RS17570	COG5000	phosphorelay sensor kinase activity
B3921_RS17580	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
B3921_RS17580	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B3921_RS17590	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
B3921_RS17615	COG0583	DNA-binding transcription factor activity
B3921_RS17630	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
B3921_RS17635	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B3921_RS17640	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B3921_RS17655	COG0758	DNA mediated transformation
B3921_RS17660	COG1522	sequence-specific DNA binding
B3921_RS17670	COG0242	peptide deformylase activity
B3921_RS17680	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
B3921_RS17690	COG0546	phosphoglycolate phosphatase activity
B3921_RS17710	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B3921_RS17715	COG1942	4-Oxalocrotonate Tautomerase
B3921_RS17720	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B3921_RS17740	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B3921_RS17760	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B3921_RS17765	COG1024	Enoyl-CoA hydratase
B3921_RS17770	COG1414	Transcriptional regulator
B3921_RS17775	COG0318	PFAM AMP-dependent synthetase and ligase
B3921_RS17780	COG3181	Tripartite tricarboxylate transporter family receptor
B3921_RS17810	COG0583	DNA-binding transcription factor activity
B3921_RS17825	COG3422	double-strand break repair
B3921_RS17830	COG0330	HflC and HflK could
B3921_RS17840	COG0251	oxidation-reduction process
B3921_RS17885	COG3723	Recombinational DNA repair protein, rece pathway
B3921_RS17920	COG0582	viral genome integration into host DNA
B3921_RS17945	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
B3921_RS17955	COG0706	membrane insertase activity
B3921_RS17960	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
B3921_RS17965	COG0594	ribonuclease P activity
B3921_RS17970	COG0230	Belongs to the bacterial ribosomal protein bL34 family
B3921_RS17975	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
B3921_RS17990	COG1414	Transcriptional regulator
B3921_RS17995	COG0154	amidase activity
B3921_RS18010	COG1304	FMN binding
B3921_RS18030	COG1960	acyl-CoA dehydrogenase activity
B3921_RS18050	COG1960	acyl-CoA dehydrogenase activity
B3921_RS18060	COG0183	Belongs to the thiolase family
B3921_RS18065	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B3921_RS18080	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B3921_RS18085	COG3181	Tripartite tricarboxylate transporter family receptor
B3921_RS18095	COG2358	TRAP transporter, solute receptor (TAXI family
B3921_RS18105	COG1629	transport
B3921_RS18110	COG2922	Belongs to the Smg family
B3921_RS18135	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
B3921_RS18140	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B3921_RS18145	COG1028	Short-chain dehydrogenase reductase Sdr
B3921_RS18150	COG1012	belongs to the aldehyde dehydrogenase family
B3921_RS18160	COG0028	Belongs to the TPP enzyme family
B3921_RS18165	COG1522	sequence-specific DNA binding
B3921_RS18170	COG3781	membrane
B3921_RS18180	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B3921_RS18200	COG4206	TonB-dependent receptor
B3921_RS18205	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B3921_RS18210	COG2022	thiamine diphosphate biosynthetic process
B3921_RS18215	COG0351	phosphomethylpyrimidine kinase
B3921_RS18220	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
B3921_RS18235	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
B3921_RS18245	COG0628	permease
B3921_RS18255	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
B3921_RS18265	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
B3921_RS18270	COG0049	tRNA binding
B3921_RS18275	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
B3921_RS18280	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B3921_RS18285	COG0051	transcription antitermination factor activity, RNA binding
B3921_RS18290	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
B3921_RS18295	COG0088	Forms part of the polypeptide exit tunnel
B3921_RS18300	COG0089	rRNA binding
B3921_RS18305	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
B3921_RS18310	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
B3921_RS18315	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
B3921_RS18320	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
B3921_RS18325	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
B3921_RS18330	COG0255	Belongs to the universal ribosomal protein uL29 family
B3921_RS18335	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
B3921_RS18355	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
B3921_RS18360	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
B3921_RS18365	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
B3921_RS18370	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
B3921_RS18375	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
B3921_RS18380	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
B3921_RS18385	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
B3921_RS18390	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
B3921_RS18395	COG1841	ribosomal large subunit assembly
B3921_RS18400	COG0200	Binds to the 23S rRNA
B3921_RS18405	COG0201	protein transport
B3921_RS18410	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
B3921_RS18415	COG0257	Belongs to the bacterial ribosomal protein bL36 family
B3921_RS18420	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
B3921_RS18425	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
B3921_RS18430	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
B3921_RS18435	COG0202	RNA polymerase activity
B3921_RS18440	COG0203	ribosomal protein L17
B3921_RS18450	COG1324	tolerance protein
B3921_RS18455	COG4232	protein-disulfide reductase activity
B3921_RS18470	COG0218	Necessary for normal cell division and for the maintenance of normal septation
B3921_RS18480	COG1333	cytochrome c biogenesis protein
B3921_RS18485	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B3921_RS18495	COG1965	Belongs to the frataxin family
B3921_RS18505	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
B3921_RS18510	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
B3921_RS18515	COG0232	Belongs to the dGTPase family. Type 2 subfamily
B3921_RS18530	COG2814	Major facilitator Superfamily
B3921_RS18535	COG0629	single-stranded DNA binding
B3921_RS18575	COG0402	S-adenosylhomocysteine deaminase activity
B3921_RS18585	COG0438	transferase activity, transferring glycosyl groups
B3921_RS18605	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B3921_RS18630	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
B3921_RS18635	COG2186	Transcriptional regulator
B3921_RS18655	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B3921_RS18660	COG1956	GAF domain-containing protein
B3921_RS18665	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B3921_RS18675	COG1652	LysM domain
B3921_RS18690	COG0220	tRNA (guanine-N7-)-methyltransferase activity
B3921_RS18705	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B3921_RS18730	COG3181	Tripartite tricarboxylate transporter family receptor
B3921_RS18745	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B3921_RS18760	COG1024	Enoyl-CoA hydratase
B3921_RS18775	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B3921_RS18780	COG1309	transcriptional regulator
B3921_RS18785	COG2816	NAD+ diphosphatase activity
B3921_RS18790	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
B3921_RS18875	COG2814	Major facilitator Superfamily
B3921_RS18880	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
B3921_RS18900	COG1999	signal sequence binding
B3921_RS18905	COG0109	protoheme IX farnesyltransferase activity
B3921_RS18945	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
B3921_RS18965	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
B3921_RS18970	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
B3921_RS18980	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
B3921_RS18985	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
B3921_RS18995	COG0067	glutamate synthase
B3921_RS18995	COG0069	glutamate synthase activity
B3921_RS18995	COG0070	glutamate synthase
B3921_RS19005	COG3047	cAMP biosynthetic process
B3921_RS19015	COG1127	ABC transporter
B3921_RS19020	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
B3921_RS19025	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
B3921_RS19030	COG2853	Lipoprotein
B3921_RS19040	COG1131	(ABC) transporter
B3921_RS19045	COG0842	Transport permease protein
B3921_RS19055	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
B3921_RS19060	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
B3921_RS19065	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
B3921_RS19070	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B3921_RS19075	COG0131	Imidazoleglycerol-phosphate dehydratase
B3921_RS19080	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
B3921_RS19085	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
B3921_RS19090	COG0107	imidazoleglycerol-phosphate synthase activity
B3921_RS19095	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
B3921_RS19100	COG0140	phosphoribosyl-ATP diphosphatase activity
B3921_RS19105	COG0537	adenosine 5'-monophosphoramidase activity
B3921_RS19110	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B3921_RS19115	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B3921_RS19130	COG3181	Tripartite tricarboxylate transporter family receptor
B3921_RS19165	COG3702	type iv secretory pathway
B3921_RS19170	COG3451	type IV secretory pathway VirB4
B3921_RS19185	COG3736	Type IV secretory pathway, component VirB8
B3921_RS19190	COG3504	Conjugal transfer protein
B3921_RS19195	COG2948	multi-organism process
B3921_RS19200	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
B3921_RS19210	COG0697	spore germination
B3921_RS19230	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
B3921_RS19235	COG0747	negative chemotaxis
B3921_RS19240	COG0601	transmembrane transport
B3921_RS19245	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B3921_RS19250	COG0444	Belongs to the ABC transporter superfamily
B3921_RS19260	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
B3921_RS19270	COG0494	nUDIX hydrolase
B3921_RS19310	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
B3921_RS19315	COG0237	dephospho-CoA kinase activity
B3921_RS19320	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
B3921_RS19335	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
B3921_RS19340	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
B3921_RS19350	COG0477	Major facilitator Superfamily
B3921_RS19355	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
B3921_RS19370	COG1126	abc transporter atp-binding protein
B3921_RS19375	COG0765	amino acid transport
B3921_RS19380	COG4597	amino acid ABC transporter
B3921_RS19385	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B3921_RS19390	COG2884	Cell division ATP-binding protein ftsE
B3921_RS19395	COG2177	Part of the ABC transporter FtsEX involved in
B3921_RS19400	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
B3921_RS19410	COG1194	a g-specific adenine glycosylase
B3921_RS19420	COG2226	methyltransferase
B3921_RS19435	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B3921_RS19440	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B3921_RS19455	COG1024	Enoyl-CoA hydratase
B3921_RS19475	COG1024	Enoyl-CoA hydratase
B3921_RS19480	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B3921_RS19485	COG3181	Tripartite tricarboxylate transporter family receptor
B3921_RS19495	COG0753	catalase activity
B3921_RS19500	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B3921_RS19505	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
B3921_RS19515	COG2175	clavaminate synthase activity
B3921_RS19520	COG1473	amidohydrolase
B3921_RS19525	COG4608	Belongs to the ABC transporter superfamily
B3921_RS19530	COG0444	Belongs to the ABC transporter superfamily
B3921_RS19545	COG0747	negative chemotaxis
B3921_RS19550	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
B3921_RS19585	COG0436	Aminotransferase
B3921_RS19590	COG1278	Cold shock